Spleen tonifying formula for acute pancreatitis spleen deficiency and excessive dampness syndrome and application of spleen tonifying formula

Abstract

The invention provides a spleen-tonifying formula aiming at spleen deficiency and excessive dampness of acute pancreatitis and application of the spleen-tonifying formula. The formula consists of the following components: 30g of raw bighead atractylodes rhizome, 20g of poria cocos, 20g of raw coix seed, 10g of radix bupleuri, 15g of rhizoma cyperi, 15g of immature bitter orange, 15g of mangnolia officinalis, 6g of raw rhubarb, 10g of rhizoma corydalis, 10g of radix aucklandiae and 8g of scutellaria baicalensis. The preparation method comprises the following steps: preparing materials, cleaning medicinal materials, soaking the medicinal materials, decocting the medicinal materials, decocting again, concentrating liquid medicine and storing the liquid medicine, wherein each step has detailed operation requirements. Effective components of the medicinal materials can be fully decocted through the scientific preparation method, and the quality and curative effect of the liquid medicine are improved; the traditional Chinese medicine materials adopted in the formula are small in side effect compared with western medicines, and the formula aims at the spleen deficiency and excessive dampness syndrome of acute pancreatitis and can effectively relieve the spleen deficiency and excessive dampness syndrome by adopting a treatment method of tonifying the spleen, eliminating dampness and promoting qi circulation to relieve pain.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine formulas, and in particular to a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome and an application thereof. Background Art

[0002] Acute pancreatitis is a common digestive system disease with rapid onset and severe condition, which poses a serious threat to the patient's health. In traditional Chinese medicine theory, acute pancreatitis with spleen deficiency and dampness is a common syndrome.

[0003] The Chinese invention patent application number: CN201210169076.8 proposes a new technology for the treatment of acute pancreatitis, which overcomes the long-standing problem that Western medicine and other drugs cannot cure acute pancreatitis. The formula: 12 herbs including bupleurum (12-17) g, raw white peony root (12-17) g, Toosendan fruit (12-17) g, Scutellaria baicalensis (8-12) g, Coptis chinensis (8-12) g, costusroot (8-12) g, radix sylvestris (8-12) g, rhubarb powder (8-12) g, Corydalis yanhusuo (10-14) g, and raw rhubarb (10-14) g. The pharmacological effects of the formula: clearing away heat and dampness, soothing the liver and purging fire, eliminating stagnation and stopping vomiting, promoting qi and stopping pain, and benefiting the stomach and strengthening the spleen. Some cured cases have proved that Huanglian Shugan Qingyi Pills are the invention of the applicant for the treatment of acute pancreatitis.

[0004] At present, the existing technologies for the treatment of acute pancreatitis with spleen deficiency and dampness have the following main deficiencies: the existing treatment methods often focus on a single treatment method, such as simple Western medicine treatment or traditional Chinese medicine prescription treatment. However, a single treatment method may not be able to effectively treat the various symptoms of spleen deficiency and dampness syndrome comprehensively, resulting in unsatisfactory treatment effects.

[0005] Existing Chinese medicine formulas may have unreasonable aspects in drug selection and compatibility, which cannot give full play to the synergistic effects of Chinese medicine and make it difficult to achieve the ideal effects of strengthening the spleen and removing dampness, promoting qi and relieving pain.

[0006] In the preparation process of traditional Chinese medicine, the existing methods may have some defects. For example, the active ingredients may be lost when washing the medicinal materials, and the active ingredients of the medicinal materials may not be fully decocted during the decoction process, which affects the quality and efficacy of the medicinal solution.

[0007] Some treatment methods of Western medicine may bring certain side effects, impose additional burden on the patient's body, and affect the safety of treatment and patient compliance.

[0008] The existing treatment options may have certain limitations in terms of applicability and cannot meet the needs of patients with different conditions. Therefore, we have made improvements to this and proposed a spleen-strengthening formula and its application for acute pancreatitis with spleen deficiency and dampness syndrome. Summary of the invention

[0009] The purpose of the present invention is to solve the problems raised by the existing background technology. In order to achieve the above invention purpose, the present invention provides the following technical scheme: a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome, the formula is composed of the following ingredients: raw Atractylodes macrocephala, Poria cocos, raw Coix seeds, Bupleurum root, Cyperus rotundus, Citrus aurantium, Magnolia bark, raw rhubarb, Corydalis yanhusuo, costus root, and Scutellaria baicalensis.

[0010] As a preferred technical solution of the present invention, the weight of the following ingredients is taken: 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seeds, 10g of Bupleurum, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Aucklandia lappa, and 8g of Scutellaria baicalensis.

[0011] A method for preparing a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome comprises the following steps:

[0012] Step 1. Prepare materials:

[0013] Step 11, according to the given formula, accurately weigh 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seeds, 10g of Bupleurum, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Aucklandia lappa, and 8g of Scutellaria baicalensis; it is recommended to purchase the medicinal materials from a regular Chinese medicine store to ensure their quality and purity;

[0014] Step 12: Prepare the necessary utensils, including casserole, strainer, stirring rod, and measuring cup;

[0015] Step 2: Clean the herbs:

[0016] Step 21. Place all the herbs in a clean container and rinse gently with clean water to remove dust and impurities on the surface;

[0017] Step 22: Rhubarb should be washed as quickly as possible to avoid soaking for a long time because its active ingredients are easily soluble in water;

[0018] Step 3: Soak the herbs:

[0019] Step 31: Put the washed herbs into a casserole and add an appropriate amount of water; the amount of water should be 3-5 cm above the surface of the herbs;

[0020] Step 32: Soaking for 40-60 minutes to allow the medicinal materials to fully absorb water, which is conducive to decocting the effective ingredients;

[0021] Step 4: Decoction of herbs:

[0022] Step 41: After soaking is completed, place the casserole on the stove and boil the medicinal liquid over high heat;

[0023] Step 42: After boiling, immediately turn the heat to low to keep the liquid at a slight boil;

[0024] Step 43, simmering over low heat for 30-40 minutes, stirring with a stirring rod every 5-10 minutes to ensure that the medicinal materials are heated evenly and the effective ingredients are fully released;

[0025] Step 44: After the decoction is completed, filter the medicinal liquid with a filter to obtain the first decoction liquid, and pour it into a clean container;

[0026] Step 5: Boil again:

[0027] Step 51: put the filtered medicinal residue back into the casserole, add an appropriate amount of clean water, and the amount of water should be 2-3 cm above the surface of the medicinal residue;

[0028] Step 52: Boil over high heat, then simmer over low heat for 20-30 minutes according to the first decocting method;

[0029] Step 53: After the decoction is completed, the medicinal liquid is filtered again with a filter to obtain a second decoction liquid, which is combined with the first decoction liquid;

[0030] Step 6: Concentrate the liquid medicine:

[0031] Step 61, concentrate the liquid medicine and pour the combined liquid medicine into a clean pot;

[0032] Step 62: Heat slowly over low heat while stirring constantly to prevent the liquid from sticking to the bottom or burning;

[0033] Step 63, concentrating until the total amount of the liquid medicine is reduced by 1 / 3-1 / 2, and the specific degree of concentration is adjusted as needed;

[0034] Step 7: Store the solution:

[0035] Step 71, cooling the prepared drug solution to room temperature;

[0036] Step 72: putting into a sterilized sealed container, including a glass bottle or a plastic bottle;

[0037] Step 73: Store the liquid medicine in a refrigerator and consume it within 3-5 days.

[0038] As a preferred technical solution of the present invention, in step 2, during the process of cleaning the medicinal materials, the medicinal materials are placed in a clean container and rinsed for 30 seconds to 1 minute. Among them, the cleaning time of rhubarb, because its effective ingredients are easily soluble in water, is no more than 10 seconds. The cleaning method is: put the raw rhubarb alone in a small container, quickly add clean water, shake it gently and then pour out the water immediately.

[0039] As a preferred technical solution of the present invention, in step 3, during the soaking process of the medicinal materials, the capacity of the casserole is 3-5 times the volume of the medicinal materials, the amount of water added exceeds the surface of the medicinal materials by 3-5 cm, and the soaking temperature is 20-25°C.

[0040] As a preferred technical solution of the present invention, in step 4, the boiling time of the decocted medicinal materials is 10-15 minutes; the medicinal liquid is filtered out with a filter screen, and the filter screen aperture is selected to be 80-100 mesh.

[0041] As a preferred technical solution of the present invention, in step 5, during the second decoction, the boiling time on high heat is 8-12 minutes, and the fire after switching to low heat is to keep the medicinal liquid in a slightly boiling state for 5 minutes; the decoction time on low heat is 12-18 minutes.

[0042] As a preferred technical solution of the present invention, in step 6, the material of the pot during the process of concentrating the medicinal solution is selected to be a stainless steel pot or a ceramic pot, and the concentration time is 30-60 minutes.

[0043] The invention discloses an application of a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome. The invention discloses an application of a spleen-strengthening and pancreas-clearing Chinese medicine decoction for acute pancreatitis with the formula. The Chinese medicine decoction for spleen-strengthening and pancreas-clearing is prepared by using 30g of raw atractylodes macrocephala, 20g of tuckahoe, 20g of raw coix seed, 10g of bupleurum, 15g of cyperus rotundus, 15g of immature bitter orange, 15g of magnolia bark, 6g of raw rhubarb, 10g of corydalis, 10g of costusroot, and 8g of scutellaria baicalensis. The decoction is taken twice a day, morning and evening, has the effects of strengthening the spleen and removing dampness, regulating qi and relieving pain, and is suitable for patients with acute pancreatitis with spleen deficiency and dampness excess syndrome.

[0044] The invention discloses an application of a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome, and an application of a spleen-strengthening and pancreas-clearing Chinese medicine powder prepared by the formula; 30g of raw atractylodes macrocephala, 20g of tuckahoe, 20g of raw coix seed, 10g of bupleurum, 15g of cyperus rotundus, 15g of immature bitter orange, 15g of magnolia bark, 6g of raw rhubarb, 10g of corydalis, 10g of costusroot, and 8g of scutellaria are dried, then ground into fine powder, mixed evenly, and the powder is easy to carry and take, and is applied to patients with mild symptoms or those requiring long-term conditioning.

[0045] Compared with the prior art, the beneficial effects of the present invention are as follows: In the scheme of the present invention: This formula targets the syndrome of spleen deficiency and dampness excess in acute pancreatitis, and adopts the treatment methods of invigorating the spleen and removing dampness, promoting qi and relieving pain, which can effectively alleviate the symptoms of the syndrome of spleen deficiency and dampness excess, such as abdominal distension, loss of appetite, and loose stools, and is targeted at the treatment of acute pancreatitis.

[0046] The Chinese medicine formula is reasonable: raw Atractylodes macrocephala can invigorate the spleen and replenish qi, dry dampness and promote diuresis; Poria can promote diuresis and eliminate dampness, invigorate the spleen and calm the mind; raw Coix seeds can invigorate the spleen and eliminate dampness, remove numbness and stop diarrhea; Bupleurum can harmonize the exterior and interior, soothe the liver and raise yang; Cyperus rotundus can soothe the liver and relieve depression, regulate qi and relieve fullness; Citrus aurantium can break up qi and eliminate accumulation, resolve phlegm and relieve lumps; Magnolia officinalis can dry dampness and eliminate phlegm, lower qi and eliminate fullness; raw rhubarb can purge accumulation, clear heat and purge fire, cool blood and detoxify, remove blood stasis and promote menstruation; Corydalis yanhusuo can promote blood circulation, promote qi and relieve pain; Aucklandia lappa can promote qi and relieve pain, invigorate the spleen and promote digestion; Scutellaria baicalensis is bitter and cold, can clear heat and purge fire, dry dampness and detoxify. All the medicines are used together to play the effects of invigorating the spleen and removing dampness, promoting qi and relieving pain. The formula is reasonable and can play a synergistic role to improve the treatment effect.

[0047] The preparation method includes the steps of preparing materials, cleaning medicinal materials, soaking medicinal materials, decocting medicinal materials, decocting again, concentrating medicinal liquid and storing medicinal liquid, and each step has detailed operation requirements and precautions. This scientific preparation method can ensure that the effective ingredients of the medicinal materials are fully decocted and improve the quality and efficacy of the medicinal liquid.

[0048] When cleaning medicinal materials, pay attention to removing dust and impurities on the surface. At the same time, for medicinal materials such as raw rhubarb whose active ingredients are easily soluble in water, adopt a quick cleaning method to avoid the loss of active ingredients.

[0049] Soaking medicinal materials can allow them to fully absorb water, which is beneficial to the extraction of effective ingredients. The soaking time and water volume are clearly stipulated to ensure the effect of soaking.

[0050] When decocting herbs, first boil them over high heat, then keep them at a low boil, and stir them at regular intervals to heat the herbs evenly and fully release the active ingredients. The double decoction method can fully extract the active ingredients in the herbs and increase the concentration of the liquid medicine.

[0051] Concentrated liquid medicine can make the concentration of liquid medicine moderate, which is convenient for taking and storage. When storing liquid medicine, the liquid medicine is cooled to room temperature and then placed in a sterilized sealed container and stored in a refrigerator to ensure the quality and safety of the liquid medicine.

[0052] This formula uses Chinese medicinal materials, which have fewer side effects than Western medicine. During the preparation process, the operation requirements are strictly followed to avoid contamination and deterioration of the medicinal materials, further improving the safety of the medicine.

[0053] The formula can be prepared into a Chinese medicine decoction, which is taken twice a day, morning and evening, or it can be prepared into a Chinese medicine powder, which is easy to carry and take, and is suitable for patients with mild illnesses or who need long-term conditioning. This diversified application method expands the scope of application of the formula and can meet the needs of different patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0054] Figure 1 The formula logic block diagram provided by the present invention;

[0055] Figure 2 The experimental data table provided by the present invention;

[0056] Figure 3 The present invention provides a flow chart of the preparation method. DETAILED DESCRIPTION

[0057] To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be described clearly and completely in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them.

[0058] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely represents some embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. It should be noted that the embodiments of the present invention and the features and technical solutions in the embodiments can be combined with each other without conflict. It should be noted that similar numbers and letters represent similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0059] Example 1: Please refer to Figure 1 , a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness syndrome, the formula consists of the following ingredients: raw Atractylodes macrocephala, Poria cocos, raw Coix seeds, Bupleurum chinense, Cyperus rotundus, Citrus aurantium, Magnolia officinalis, raw Rhubarb, Corydalis yanhusuo, costus root, and Scutellaria baicalensis.

[0060] Take the weight of the following ingredients: 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seed, 10g of Bupleurum chinense, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Aucklandia lappa, and 8g of Scutellaria baicalensis.

[0061] This formula is aimed at acute pancreatitis with spleen deficiency and dampness, and its main treatment method is to strengthen the spleen and eliminate dampness, promote qi and relieve pain. The working mechanism of each herbal medicine in the formula is as follows:

[0062] Raw Atractylodes macrocephala: strengthens the spleen and replenishes Qi, expels dampness and promotes diuresis. It is the main medicine that can enhance the function of the spleen and stomach and transport and transform water and dampness.

[0063] Poria: It can promote diuresis and eliminate dampness, strengthen the spleen and calm the mind, and assist Atractylodes macrocephala in enhancing its effect of strengthening the spleen and eliminating dampness.

[0064] Raw coix seeds: strengthen the spleen, drain dampness, eliminate numbness and stop diarrhea, further enhancing the effect of removing dampness.

[0065] Bupleurum: It can harmonize the exterior and interior, soothe the liver and raise yang, relieve liver qi and regulate qi.

[0066] Cyperus rotundus: Soothes the liver and relieves depression, regulates qi and relieves fullness, and enhances the liver-soothing and qi-regulating effects of Bupleurum chinense.

[0067] Zhishi: breaks up qi and eliminates accumulation, resolves phlegm and relieves abdominal distension, promotes qi circulation and eliminates stagnation, to relieve bloating.

[0068] Magnolia officinalis: dries up dampness and eliminates phlegm, relieves Qi and relieves fullness, and helps Citrus aurantium to promote Qi and dry dampness.

[0069] Raw rhubarb: has the effect of purging qi and removing stagnation, clearing away heat and purging fire, cooling blood and detoxifying, removing blood stasis and relieving menstruation. It can clear the bowels, purge heat, remove blood stasis and relieve pain.

[0070] Yuanhu: promotes blood circulation, promotes qi circulation, and relieves pain, and enhances the effect of promoting qi circulation and relieving pain.

[0071] Costus root: promotes qi circulation and relieves pain, strengthens the spleen and aids digestion, and regulates the qi of the spleen and stomach.

[0072] Scutellaria baicalensis: Scutellaria baicalensis is bitter and cold, and can clear away heat, purge fire, dry dampness and detoxify. It can be used to treat damp-heat jaundice, diarrhea, and eczema. Its mechanism of clearing heat and drying dampness may be related to inhibiting bacterial growth and regulating the balance of intestinal flora. Scutellaria baicalensis has a strong fire-clearing and detoxifying effect, and can be used to treat sores, swellings, and sore throats caused by intense heat and toxicity. Its detoxifying effect may be related to the antioxidant, anti-inflammatory, and immunomodulatory activities of the flavonoids contained in Scutellaria baicalensis.

[0073] Example 2: Preparation method of spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome, please refer to Figure 3 , including the following steps:

[0074] Step 1. Prepare the materials: Step 11. According to the given formula, accurately weigh 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seeds, 10g of Bupleurum, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Aucklandia lappa, and 8g of Scutellaria baicalensis. It is recommended to purchase the herbs from a regular Chinese medicine store to ensure their quality and purity. Step 12. Prepare the necessary utensils, including a casserole, a strainer, a stirring rod, and a measuring cup.

[0075] Step 2: Wash the herbs: Step 21: Put all herbs in a clean container and rinse gently with clean water to remove dust and impurities on the surface; Step 22: Raw rhubarb should be washed as quickly as possible because its active ingredients are easily soluble in water and avoid soaking for a long time;

[0076] Step 3, soaking the herbs: Step 31, put the washed herbs into a casserole, add an appropriate amount of water; the amount of water should be 3-5 cm above the surface of the herbs;

[0077] Step 32: Soaking for 40-60 minutes to allow the medicinal materials to fully absorb water, which is conducive to decocting the effective ingredients;

[0078] Step 4: Decoction of herbs: Step 41: After soaking, place the casserole on the stove and boil the herbs over high heat;

[0079] Step 42: After boiling, immediately turn the heat to low to keep the liquid at a slight boil;

[0080] Step 43, simmering over low heat for 30-40 minutes, stirring with a stirring rod every 5-10 minutes to ensure that the medicinal materials are heated evenly and the effective ingredients are fully released;

[0081] Step 44: After the decoction is completed, filter the medicinal liquid with a filter to obtain the first decoction liquid, and pour it into a clean container;

[0082] Step 5, decoct again: Step 51, put the filtered medicinal residue back into the casserole, add an appropriate amount of clean water, the amount of water should be 2-3 cm above the surface of the medicinal residue;

[0083] Step 52: Boil over high heat, then simmer over low heat for 20-30 minutes according to the first decocting method;

[0084] Step 53: After the decoction is completed, the medicinal liquid is filtered again with a filter to obtain a second decoction liquid, which is combined with the first decoction liquid;

[0085] Step 6, concentrating the liquid medicine: Step 61, concentrating the liquid medicine: Pour the combined liquid medicine into a clean pot;

[0086] Step 62: Heat slowly over low heat while stirring constantly to prevent the liquid from sticking to the bottom or burning;

[0087] Step 63, concentrating until the total amount of the liquid medicine is reduced by 1 / 3-1 / 2, and the specific degree of concentration is adjusted as needed;

[0088] Step 7, storing the drug solution: Step 71, cooling the prepared drug solution to room temperature;

[0089] Step 72: putting into a sterilized sealed container, including a glass bottle or a plastic bottle;

[0090] Step 73: Store the liquid medicine in a refrigerator and consume it within 3-5 days.

[0091] Step 2: When cleaning the medicinal materials, put them in a clean container and rinse them for 30 seconds to 1 minute. The cleaning time for rhubarb should not exceed 10 seconds because its active ingredients are easily soluble in water. The cleaning method is: put the raw rhubarb alone in a small container, quickly add clean water, shake it gently and pour out the water immediately.

[0092] Step 3: During the soaking process, the capacity of the casserole should be 3-5 times the volume of the herbs, and the amount of water added should exceed the surface of the herbs by 3-5 cm. The soaking temperature should be 20-25℃.

[0093] Step 4: Boil the decocted herbs for 10-15 minutes; filter the medicinal liquid with a filter with an aperture of 80-100 mesh.

[0094] Step 5. During the second decoction, boil on high heat for 8-12 minutes. Turn to low heat and keep the medicine liquid in a slightly boiling state for 5 minutes; boil on low heat for 12-18 minutes.

[0095] Step 6: During the process of concentrating the medicine liquid, the pot material should be stainless steel or ceramic, and the concentration time is 30-60 minutes.

[0096] The preparation method of the present invention comprises the following steps: firstly, according to a given formula, 30 g of raw atractylodes, 20 g of poria, 20 g of raw coix seed, 10 g of bupleurum, 15 g of cyperus rotundus, 15 g of immature bitter orange, 15 g of magnolia bark, 6 g of raw rhubarb, 10 g of corydalis, 10 g of costusroot, and 8 g of scutellaria are purchased from a regular Chinese medicine store, and a casserole, a filter screen with a mesh size of 80 to 100, a stirring rod, and a measuring cup are prepared.

[0097] Next, wash the herbs. Put all herbs except the raw rhubarb into a clean container and rinse gently with clean water for 30 seconds to 1 minute to remove surface dust and impurities. Then, put the raw rhubarb alone into a small container, quickly add clean water, shake gently and immediately pour out the water. The washing time should not exceed 10 seconds.

[0098] Put the washed herbs into a casserole (the capacity of the casserole is 3-5 times the volume of the herbs), add an appropriate amount of water, and the water level should exceed the surface of the herbs by 3-5 cm. Soak for 40-60 minutes at 20-25℃ to allow the herbs to fully absorb the water.

[0099] After soaking, place the casserole on the stove and boil the liquid medicine over high heat for 10-15 minutes. After boiling, immediately turn to low heat to keep the liquid medicine slightly boiling. Simmer over low heat for 30-40 minutes, stirring with a stirring rod every 5-10 minutes. After boiling, filter the liquid medicine with a 80-100 mesh filter to obtain the first decoction liquid, and pour it into a clean container.

[0100] Put the filtered medicinal residue back into the casserole, add an appropriate amount of water, and the amount of water should exceed the surface of the medicinal residue by 2-3 cm. According to the method of the first decoction, boil it for 8-12 minutes on high heat, and then turn to low heat for decoction. After turning to low heat, keep the medicinal liquid in a slightly boiling state for 5 minutes, and decoct it on low heat for 12-18 minutes. After the decoction is completed, filter the medicinal liquid again with a filter to obtain the second decoction liquid, which is combined with the first decoction liquid.

[0101] Pour the combined liquid into a stainless steel or ceramic pot and heat slowly over low heat while stirring constantly to prevent the liquid from sticking to the bottom or burning. Concentrate for 30-60 minutes until the total amount of liquid is reduced by 1 / 3-1 / 2. The specific degree of concentration can be adjusted as needed.

[0102] Finally, cool the prepared liquid medicine to room temperature and put it into a sterilized sealed glass or plastic bottle. Store the liquid medicine in the refrigerator and consume it within 3-5 days.

[0103] Example 3: An application of a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome, wherein a spleen-strengthening and pancreas-clearing Chinese medicine decoction is prepared by using the formula, and 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seed, 10g of Bupleurum chinense, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Costus root, and 8g of Scutellaria baicalensis are prepared into a spleen-strengthening and pancreas-clearing Chinese medicine decoction, which is taken twice a day, morning and evening, and has the effects of strengthening the spleen and removing dampness, regulating qi and relieving pain, and is suitable for patients with acute pancreatitis with spleen deficiency and dampness excess syndrome.

[0104] The invention discloses an application of a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome, and an application of a spleen-strengthening and pancreas-clearing Chinese medicine powder prepared by the formula; 30g of raw atractylodes macrocephala, 20g of tuckahoe, 20g of raw coix seed, 10g of bupleurum, 15g of cyperus rotundus, 15g of immature bitter orange, 15g of magnolia bark, 6g of raw rhubarb, 10g of corydalis, 10g of costusroot, and 8g of scutellaria are dried, then ground into fine powder, mixed evenly, and the powder is easy to carry and take, and is applied to patients with mild symptoms or those requiring long-term conditioning.

[0105] This formula is aimed at the syndrome of spleen deficiency and dampness excess in acute pancreatitis. It adopts the treatment methods of strengthening the spleen and removing dampness, promoting qi and relieving pain. It can effectively relieve the symptoms of spleen deficiency and dampness excess, such as abdominal distension, loss of appetite, and loose stools, and is targeted for the treatment of acute pancreatitis.

[0106] The Chinese medicine formula is reasonable: the raw Atractylodes macrocephala in the formula strengthens the spleen and replenishes qi, dries dampness and promotes diuresis; Poria promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind; raw Coix seeds strengthen the spleen and eliminate dampness, remove numbness and stop diarrhea; Bupleurum harmonizes the exterior and interior, soothes the liver and raises yang; Cyperus rotundus soothes the liver and relieves depression, regulates qi and relieves fullness; Citrus aurantium breaks up qi and eliminates accumulation, resolves phlegm and relieves lumps; Magnolia bark dries dampness and eliminates phlegm, lowers qi and eliminates fullness; raw rhubarb is purgative, attacks accumulation, clears heat and purges fire, cools blood and detoxifies, removes blood stasis and promotes menstruation; Corydalis yanhusuo promotes blood circulation, promotes qi and relieves pain; Aucklandia lappa promotes qi and relieves pain, strengthens the spleen and promotes digestion; Scutellaria baicalensis warms the middle and dispels cold, restores yang and unblocks the meridians. The combination of these medicines can play a synergistic role in strengthening the spleen and removing dampness, promoting qi and relieving pain. The formula is reasonable and can play a synergistic role to improve the treatment effect.

[0107] The preparation method includes the steps of preparing materials, cleaning medicinal materials, soaking medicinal materials, decocting medicinal materials, decocting again, concentrating medicinal liquid and storing medicinal liquid, and each step has detailed operation requirements and precautions. This scientific preparation method can ensure that the effective ingredients of the medicinal materials are fully decocted and improve the quality and efficacy of the medicinal liquid.

[0108] When cleaning medicinal materials, pay attention to removing dust and impurities on the surface. At the same time, for medicinal materials such as raw rhubarb whose active ingredients are easily soluble in water, adopt a quick cleaning method to avoid the loss of active ingredients.

[0109] Soaking medicinal materials can allow them to fully absorb water, which is beneficial to the extraction of effective ingredients. The soaking time and water volume are clearly stipulated to ensure the effect of soaking.

[0110] When decocting herbs, first boil them over high heat, then keep them at a low boil, and stir them at regular intervals to heat the herbs evenly and fully release the active ingredients. The double decoction method can fully extract the active ingredients in the herbs and increase the concentration of the liquid medicine.

[0111] Concentrated liquid medicine can make the concentration of liquid medicine moderate, which is convenient for taking and storage. When storing liquid medicine, the liquid medicine is cooled to room temperature and then placed in a sterilized sealed container and stored in a refrigerator to ensure the quality and safety of the liquid medicine.

[0112] This formula uses Chinese medicinal materials, which have fewer side effects than Western medicine. During the preparation process, the operation requirements are strictly followed to avoid the contamination and deterioration of the medicinal materials, further improving the safety of the medicine. The formula can be prepared into a Chinese medicine decoction, which is taken twice a day, morning and evening, or it can be prepared into a Chinese medicine powder, which is easy to carry and take, and is suitable for patients with mild illness or who need long-term conditioning. This diversified application method expands the scope of application of the formula and can meet the needs of different patients.

[0113] In the preparation method, the principles of each step are as follows:

[0114] Prepare materials: Ensure the quality and purity of the medicinal materials, as well as the completeness of the instruments, to provide guarantee for the subsequent preparation process.

[0115] Cleaning herbs:

[0116] Gently rinse the medicinal materials with clean water to remove dust and impurities on the surface. At the same time, pay attention to controlling the cleaning time of raw rhubarb to avoid excessive loss of effective ingredients.

[0117] Soaking herbs:

[0118] Choose a casserole of appropriate capacity so that the herbs have enough space when soaking.

[0119] Control the amount of water added and the soaking temperature so that the medicinal materials can fully absorb the water, which is conducive to the subsequent decoction of effective ingredients.

[0120] Decoction of herbs:

[0121] First boil the medicine over high heat to quickly boil the liquid and activate the effective ingredients of the medicinal materials.

[0122] Then turn to low heat and maintain a slight boil, and continue decocting for a while to allow the effective ingredients of the medicinal materials to be fully released into the medicine liquid.

[0123] Stir regularly to ensure that the medicinal materials are heated evenly and increase the decoction rate of effective ingredients.

[0124] Select a filter with appropriate pore size to filter the liquid medicine to remove the residue and obtain pure liquid medicine.

[0125] Re-decoction: The residue is decocted again to fully extract the effective ingredients in the medicinal materials and increase the concentration of the medicinal solution.

[0126] Concentrated liquid medicine:

[0127] Choose a pot made of suitable material, such as stainless steel or ceramic, to avoid adverse reactions between the medicine and the pot.

[0128] Heat slowly over low heat and stir constantly to allow the water in the medicine to gradually evaporate, achieving the purpose of concentration while preventing the medicine from sticking to the bottom or burning.

[0129] Storage of liquid medicine: After the liquid medicine has cooled to room temperature, it should be placed in a sterilized sealed container and stored in a refrigerator to ensure its quality and safety and extend its shelf life.

[0130] Experimental example

[0131] Experimental purpose: To verify the efficacy of this spleen-strengthening formula on acute pancreatitis with spleen deficiency and dampness excess syndrome.

[0132] Experimental subjects: 100 patients with acute pancreatitis with spleen deficiency and dampness excess syndrome were selected and randomly divided into two groups, 50 cases in each group.

[0133] Experimental group: The patients were given the spleen-strengthening Chinese medicine decoction of the present invention, and the medicine solution was prepared according to the above preparation method and taken twice a day, morning and evening.

[0134] Control group: given conventional western medicine treatment.

[0135] Experimental period: 3 weeks.

[0136] Experimental data:

[0137]

[0138] Experimental results analysis:

[0139] 1. Symptom relief time: The average symptom relief time of the experimental group was 3.0 days, and that of the control group was 4.5 days. The experimental group was significantly shorter than the control group, indicating that the spleen-strengthening formula Chinese herbal decoction can relieve the patient's symptoms faster and reduce the patient's pain.

[0140] 2. Time for pancreatic function indicators to return to normal: The average time for pancreatic function indicators to return to normal was 6.5 days in the experimental group and 8.5 days in the control group. The experimental group had a shorter recovery time, indicating that the Chinese herbal decoction has a positive effect on the recovery of pancreatic function.

[0141] 3. Improvement of TCM symptoms: The average reduction of TCM symptoms in the experimental group after treatment was 70%, and that in the control group was 50%. This shows that the spleen-strengthening formula TCM decoction is more effective in improving the TCM symptoms of spleen deficiency and dampness, and can more effectively regulate the patient's body functions.

[0142] 4. Incidence of adverse reactions: The incidence of adverse reactions in the experimental group was 5%, and that in the control group was 15%, indicating that the Chinese medicine decoction was relatively safe and had fewer adverse reactions after use.

[0143] Record of the preparation process of Chinese herbal medicine decoction

[0144]

[0145]

[0146]

[0147] Based on the above data, the spleen-strengthening formula Chinese medicine decoction for acute pancreatitis with spleen deficiency and dampness has a significant therapeutic effect in treating acute pancreatitis with spleen deficiency and dampness. It can relieve symptoms faster, promote the recovery of pancreatic function, improve TCM syndromes, and has a low incidence of adverse reactions. Therefore, the spleen-strengthening formula Chinese medicine decoction is a safe and effective method for treating acute pancreatitis with spleen deficiency and dampness, and has a high clinical application value.

[0148] The above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described in the present invention. Although the present invention has been described in detail with reference to the above embodiments, the present invention is not limited to the above specific implementation methods. Therefore, any modification or replacement of the present invention; and all technical solutions and improvements thereof that do not depart from the spirit and scope of the invention are included in the scope of the claims of the present invention.

Claims

1. A spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome, characterized in that: The formula consists of the following ingredients: raw Atractylodes macrocephala, Poria cocos, raw Coix seeds, Bupleurum chinense, Cyperus rotundus, Citrus aurantium, Magnolia officinalis, raw Rhubarb, Corydalis yanhusuo, Costus root, and Scutellaria baicalensis.

2. A spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess according to claim 1, characterized in that: Take the weight of the following ingredients: 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seed, 10g of Bupleurum chinense, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Aucklandia lappa, and 8g of Scutellaria baicalensis.

3. A method for preparing a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome, characterized in that: The following steps are involved: Step 1. Prepare materials: Step 11, according to the given formula, accurately weigh 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seeds, 10g of Bupleurum, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Aucklandia lappa, and 8g of Scutellaria baicalensis; it is recommended to purchase the medicinal materials from a regular Chinese medicine store to ensure their quality and purity; Step 12: Prepare the necessary utensils, including casserole, strainer, stirring rod, and measuring cup; Step 2: Clean the herbs: Step 21. Place all the herbs in a clean container and rinse gently with clean water to remove dust and impurities on the surface; Step 22: Rhubarb should be washed as quickly as possible to avoid soaking for a long time because its active ingredients are easily soluble in water; Step 3: Soak the herbs: Step 31: Put the washed herbs into a casserole and add an appropriate amount of water; the amount of water should be 3-5 cm above the surface of the herbs; Step 32: Soaking for 40-60 minutes to allow the medicinal materials to fully absorb water, which is conducive to decocting the effective ingredients; Step 4: Decoction of herbs: Step 41: After soaking is completed, place the casserole on the stove and boil the medicinal liquid over high heat; Step 42: After boiling, immediately turn the heat to low to keep the liquid at a slight boil; Step 43, simmering over low heat for 30-40 minutes, stirring with a stirring rod every 5-10 minutes to ensure that the medicinal materials are heated evenly and the effective ingredients are fully released; Step 44: After the decoction is completed, filter the medicinal liquid with a filter to obtain the first decoction liquid, and pour it into a clean container; Step 5: Boil again: Step 51: put the filtered medicinal residue back into the casserole, add an appropriate amount of clean water, and the amount of water should be 2-3 cm above the surface of the medicinal residue; Step 52: Boil over high heat, then simmer over low heat for 20-30 minutes according to the first decocting method; Step 53: After the decoction is completed, the medicinal liquid is filtered again with a filter to obtain a second decoction liquid, which is combined with the first decoction liquid; Step 6: Concentrate the liquid medicine: Step 61, concentrate the liquid medicine and pour the combined liquid medicine into a clean pot; Step 62: Heat slowly over low heat while stirring constantly to prevent the liquid from sticking to the bottom or burning; Step 63, concentrating until the total amount of the liquid medicine is reduced by 1 / 3-1 / 2, and the specific degree of concentration is adjusted as needed; Step 7: Store the solution: Step 71, cooling the prepared drug solution to room temperature; Step 72: putting into a sterilized sealed container, including a glass bottle or a plastic bottle; Step 73: Store the liquid medicine in a refrigerator and consume it within 3-5 days.

4. The method for preparing a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess according to claim 3, characterized in that: Step 2: When cleaning the medicinal materials, put them in a clean container and rinse them for 30 seconds to 1 minute. The cleaning time for rhubarb should not exceed 10 seconds because its active ingredients are easily soluble in water. The cleaning method is: put the raw rhubarb alone in a small container, quickly add clean water, shake it gently and pour out the water immediately.

5. The method for preparing a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness according to claim 3, characterized in that: Step 3: During the soaking process, the capacity of the casserole should be 3-5 times the volume of the herbs, and the amount of water added should exceed the surface of the herbs by 3-5 cm. The soaking temperature should be 20-25℃.

6. The method for preparing a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess according to claim 3, characterized in that: Step 4: Boil the decocted herbs for 10-15 minutes; filter the medicinal liquid with a filter with an aperture of 80-100 mesh.

7. The method for preparing a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess according to claim 3, characterized in that: Step 5. During the second decoction, boil on high heat for 8-12 minutes. Turn to low heat and keep the medicine liquid in a slightly boiling state for 5 minutes; boil on low heat for 12-18 minutes.

8. The method for preparing a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess according to claim 3, characterized in that: Step 6: During the process of concentrating the medicine liquid, the pot material should be stainless steel or ceramic, and the concentration time is 30-60 minutes.

9. An application of a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome, characterized in that: The application of the formula for preparing a Chinese herbal decoction for invigorating the spleen and clearing the pancreas is prepared by adding 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seeds, 10g of Bupleurum, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Aucklandia lappa, and 8g of Scutellaria baicalensis to make a Chinese herbal decoction for invigorating the spleen and clearing the pancreas. The decoction is taken twice a day, morning and evening, and has the effects of invigorating the spleen and removing dampness, regulating qi and relieving pain. It is suitable for patients with acute pancreatitis with spleen deficiency and dampness syndrome.

10. The use of a spleen-strengthening formula for acute pancreatitis with spleen deficiency and dampness excess syndrome according to claim 9, characterized in that: The application of Chinese medicine powder for strengthening the spleen and clearing the pancreas is prepared by formula; 30g of raw Atractylodes macrocephala, 20g of Poria cocos, 20g of raw Coix seeds, 10g of Bupleurum, 15g of Cyperus rotundus, 15g of Citrus aurantium, 15g of Magnolia officinalis, 6g of raw Rhubarb, 10g of Corydalis yanhusuo, 10g of Aucklandia lappa, and 8g of Scutellaria baicalensis are dried, then ground into fine powder, mixed evenly, and the powder is easy to carry and take, and is used for patients with mild conditions or those requiring long-term conditioning.

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