Pipeline system capable of realizing multiple blood treatment modes

Abstract

The invention provides a pipeline system capable of realizing multiple blood treatment modes, which comprises a plurality of pipes, and the plurality of pipes form a blood passage and a liquid medicine passage; the blood passage comprises a blood sampling basic tube and a blood return basic tube; the liquid medicine channel comprises a waste liquid basic tube and a plurality of liquid medicine basic tubes used for being connected with an external treatment device or a blood channel. Various liquid flow paths can be formed to correspond to various treatment modes by adjusting the connection relation and the conduction condition of the pipes. The liquid medicine channel in the pipeline system has multiple communication paths, liquid flow paths of multiple blood treatment modes can be achieved by switching the communication conditions of the multiple pipes, the treatment requirements of the multiple blood treatment modes can be met by installing the pipeline system on blood treatment equipment, pipeline installation errors are reduced, and the treatment efficiency is improved. The pipeline installation operation is simple and convenient, and the use convenience is improved; when the blood treatment mode of the same patient needs to be changed, the pipeline does not need to be changed, and only the conduction condition of the pipeline needs to be switched.

Description

Technical Field

[0001] The present application relates to the technical field of medical equipment, and in particular to a pipeline system for realizing multiple blood treatment modes. Background Art

[0002] Blood therapy is a treatment method that removes blood from the body, removes harmful substances from the blood through purification consumables such as dialyzers, adsorbers or separators, and then transports the purified blood back into the body. Currently, there are many types of blood treatment modes in medicine, such as hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasma exchange, plasma adsorption, immunoadsorption, albumin dialysis, etc. Each mode has its own exclusive fluid flow path, which also leads to the traditional blood treatment equipment. Each mode has a corresponding pipeline. In actual use, each time the treatment mode is changed, the pipeline supporting the original mode needs to be removed and a set of pipelines matching the treatment mode to be used needs to be reinstalled. The operation is cumbersome; and before each treatment, medical staff need to install a new set of pipelines. If each mode has its own pipeline, it is not easy to identify and it is easy to cause installation errors. Summary of the invention

[0003] In view of this, the present application is committed to providing a pipeline system that realizes multiple blood treatment modes. The medicine liquid passage in the pipeline system has multiple conduction paths. By switching the conduction conditions of the tubes, the liquid flow paths of multiple blood treatment modes can be realized. Then, installing this pipeline system on the blood treatment equipment can meet the treatment needs of multiple blood treatment modes, reduce the error rate of pipeline installation, simplify the pipeline installation operation, and improve the convenience of use; and when the same patient needs to change the blood treatment mode, there is no need to disassemble the pipeline.

[0004] The present application provides a pipeline system for realizing multiple blood treatment modes, including a plurality of tubes, wherein the plurality of tubes form a blood passage and a drug solution passage;

[0005] The blood pathway includes a blood collection basic tube connected to the input end of the external therapeutic device and a blood return basic tube connected to the output end of the external therapeutic device; the drug solution pathway includes a waste liquid basic tube connected to the output end of the external therapeutic device, and multiple drug solution basic tubes connected to the external therapeutic device and / or the blood pathway. By adjusting the connection relationship and conduction conditions between the various tubes, a variety of liquid flow paths can be formed to correspond to a variety of treatment modes.

[0006] Optionally, the medicine basic tube includes: a first medicine basic tube, which can transport medicine to any one of the external treatment device, the blood collection basic tube, and the blood return basic tube, or any combination thereof; and a second medicine basic tube, which introduces medicine from the first medicine basic tube and can transport medicine to the blood collection basic tube and / or the blood return basic tube.

[0007] Optionally, the first medicine liquid basic tube includes a first main tube for connecting to a medicine liquid bag, and a first branch tube and a second branch tube both connected to the first main tube, the first branch tube being used to connect to an external therapeutic device, and the second branch tube being used to connect to the blood collection basic tube or the blood return basic tube; by selecting to connect the first branch tube or the second branch tube, and switching the second branch tube to connect to the blood collection basic tube or the blood return basic tube, liquid flow paths for three treatment modes can be formed.

[0008] Optionally, the three treatment modes are dilution before blood filtration, dilution after blood filtration and hemodialysis. In the dilution before blood filtration mode, the second branch tube is turned on and connected to the blood collection basic tube, and the medicinal solution flows into the blood collection basic tube through the first main tube and the second branch tube and flows into an external therapeutic device together with the blood; in the dilution after blood filtration mode, the second branch tube is turned on and connected to the blood return basic tube, and the medicinal solution flows into the blood return basic tube through the first main tube and the second branch tube and flows back to the human body together with the dialyzed blood; in the hemodialysis mode, the first branch tube is turned on, and the medicinal solution flows into the external therapeutic device through the first main tube and the first branch tube.

[0009] Optionally, the second medical liquid basic tube includes a second main tube connected to the liquid outlet side branch of the first main tube, a third branch tube and a fourth branch tube both connected to the second main tube, the third branch tube is connected to the second branch tube so as to be connected to the blood collection basic tube through the second branch tube, and the fourth branch tube is used to be connected to the blood collection basic tube or the blood return basic tube; by selectively conducting the third branch tube or the fourth branch tube, and switching the fourth branch tube to be connected to the blood collection basic tube or the blood return basic tube, three other treatment mode liquid flow paths can be formed.

[0010] Optionally, the other three treatment modes are pre- and post-hemofiltration mixed dilution, pre-hemodiafiltration dilution, and post-hemodiafiltration dilution;

[0011] In the pre- and post-hemofiltration mixed dilution mode, the second branch tube is connected to the blood return basic tube, the fourth branch tube is connected to the blood collection basic tube, and the liquid medicine is divided into two paths through the first main tube, one path flows into the blood return basic tube through the second branch tube, and the other path flows into the second main tube of the second liquid medicine basic tube and flows into the blood collection basic tube through the fourth branch tube;

[0012] In the dilution mode before hemodiafiltration, the first branch tube and the fourth branch tube are connected, and the liquid medicine is divided into two paths through the first main tube, one path flows into the external treatment device through the first branch tube, and the other path flows into the second main tube of the second liquid medicine basic tube and flows into the blood collection basic tube through the fourth branch tube;

[0013] In the dilution mode after hemodiafiltration, the first branch tube is turned on, the fourth branch tube is turned on and connected to the blood return basic tube, and the drug solution is divided into two paths through the first main tube, one path flows into the external treatment device through the first branch tube, and the other path flows into the blood return basic tube through the fourth branch tube.

[0014] Optionally, the drug solution passage also includes a third drug solution basic tube; the third drug solution basic tube introduces drug solution from the first drug solution basic tube and can transport drug solution to the blood collection basic tube; the first drug solution basic tube, the second drug solution basic tube and the third drug solution basic tube are connected, and by switching the conduction conditions of the three, a liquid flow path for multiple treatment modes in hemodialysis and filtration can be formed.

[0015] Optionally, one end of the third medical liquid basic tube is connected to the liquid outlet side branch of the first main tube of the first medical liquid basic tube, and the other end is connected to the blood collection basic tube;

[0016] By selecting the fourth branch tube that connects the first branch tube and the second medical solution basic tube, a liquid flow path for a pre- and post-hemodiafiltration mixed dilution treatment mode can be formed.

[0017] Optionally, the medicine liquid basic tube also includes a fourth medicine liquid basic tube; one end of the fourth medicine liquid basic tube is used to be connected to the medicine liquid bag, and the other end is used to be connected to the external therapeutic device or the blood return basic tube. By selecting whether the medicine liquid bag and the waste liquid bag are connected and selecting the output position of the fourth medicine liquid basic tube, the liquid flow paths of three treatment modes of repeated albumin dialysis, single-pass albumin dialysis, and plasma exchange can be formed.

[0018] Optionally, the medicine basic tube also includes a fifth medicine basic tube to form a liquid flow path of a plasma filtration dialysis mode through the combination of the blood collection basic tube, the waste liquid basic tube, the fourth medicine basic tube and the fifth medicine basic tube; in the plasma filtration dialysis mode, one end of the fifth medicine basic tube is connected to a medicine bag and the other end is connected to the blood return basic tube.

[0019] Optionally, the drug solution passage is further provided with a plurality of connecting tubes for corresponding connection with an external therapeutic device, and by switching and using the connecting tubes, the basic tube and the connecting tubes can be combined into a liquid flow path of a plurality of blood treatment modes.

[0020] Optionally, the connecting tube includes a first connecting tube for connecting to the input end of the external therapeutic device C, a second connecting tube for connecting to the output end of the external therapeutic device C, and a third connecting tube connecting two external therapeutic devices C; the first connecting tube, the second connecting tube, and the third connecting tube are combined with the fifth drug solution basic tube to form a liquid flow path under two treatment modes: plasma adsorption and double plasma molecule adsorption system; under these two treatment modes, one end of the fifth drug solution basic tube is connected to the output end of the external therapeutic device B arranged on the blood passage, and the other end is connected to the first connecting tube, and the second connecting tube is connected to the blood return basic tube.

[0021] Optionally, the connecting tube further includes a fourth connecting tube for connecting two external therapeutic devices A or connecting external therapeutic device B with external therapeutic device A, and the second connecting tube includes a third main tube and a fifth branch tube and a sixth branch tube both connected to the third main tube, the fifth branch tube is used to connect the blood return basic tube, and the sixth branch tube is used to connect the first external therapeutic device or the second external therapeutic device;

[0022] By combining the fourth drug solution basic tube, the fifth drug solution basic tube, the second connecting tube and the fourth connecting tube, and adjusting the number of external therapeutic devices C and the conductivity of the fifth branch tube and the sixth branch tube, liquid flow paths for three treatment modes of paired plasma filtration adsorption, plasma separation adsorption system and molecular adsorption recycling can be formed.

[0023] Optionally, in the paired plasma filtration adsorption mode, an external therapeutic device B is provided between the blood collection basic tube and the fourth connecting tube, an external therapeutic device A is provided between the fourth connecting tube and the blood return basic tube, one end of the fifth drug liquid basic tube is connected to the output end of the external therapeutic device B, and the other end is connected to the first connecting tube on the external therapeutic device C, the sixth branch of the second connecting tube on the external therapeutic device C is connected and connected to the fourth connecting tube, and the plasma separated by the external therapeutic device B flows through the fifth drug liquid basic tube, passes through an external therapeutic device C, and then flows into the external therapeutic device A;

[0024] In the plasma separation and adsorption system mode, an external therapeutic device B is arranged between the blood collection basic tube and the fourth connecting tube, an external therapeutic device A is arranged between the fourth connecting tube and the blood return basic tube, one end of the fifth liquid medicine basic tube is connected to the output end of the external therapeutic device B, and the other end is connected to the first connecting tube of the input end of the first external therapeutic device C, the first external therapeutic device C is connected to the second external therapeutic device C through the third connecting tube, the output end of the second external therapeutic device C is the second connecting tube, the sixth branch of the second connecting tube is connected and connected to the external therapeutic device B, and the plasma separated by the external therapeutic device B flows through the fifth liquid medicine basic tube in sequence through the two external therapeutic devices C and then flows back to the external therapeutic device B;

[0025] In the molecular adsorption recycling system mode, a first external therapeutic device A is arranged between the blood collection basic tube and the blood return basic tube, a second external therapeutic device A is arranged between the fourth drug solution basic tube and the waste liquid basic tube, one end of the fifth drug solution basic tube is connected to the output end of the first external therapeutic device A, and the other end is connected to the input end of the second external therapeutic device A, a first external therapeutic device C is connected to the output end of the second external therapeutic device A through the first connecting tube, and the second external therapeutic device C is connected to the input end of the first external therapeutic device A through the second connecting tube, and the blood after dialyzed by the first external therapeutic device A flows into the second external therapeutic device A through the fifth drug solution basic tube and flows through the two external therapeutic devices C in sequence after flowing out of the second external therapeutic device A and then flows back to the first external therapeutic device A.

[0026] Optionally, the connecting tube also includes a fifth connecting tube to form a liquid flow path of a double filtration plasma exchange mode through the combination of the waste liquid basic tube, the fourth medical liquid basic tube, the fifth medical liquid basic tube and the fifth connecting tube; in the double filtration plasma exchange mode, the plasma separated by the external therapeutic device B enters the external therapeutic device D through the fifth medical liquid basic tube for further separation, and the plasma output by the external therapeutic device D flows back to the blood return basic tube through the fifth connecting tube and the fourth medical liquid basic tube, and the output waste liquid flows into the waste liquid basic tube.

[0027] The pipeline system provided by the present application is that each of the liquid passages with different functions is equipped with a tube, and multiple tubes are connected to each other to form a pipeline with multiple conduction paths. Then, the same set of pipelines is applicable to multiple blood treatment modes. Installing this set of pipeline system on the blood treatment equipment can meet the treatment needs of multiple blood treatment modes. When these treatment modes are needed, only this set of pipelines needs to be installed, which reduces the error of installing the pipeline, simplifies the pipeline installation operation, and improves the convenience of use; and when the same patient needs to change the blood treatment mode, there is no need to change the pipeline, and the required liquid flow path can be formed by switching the conduction conditions of each tube. Then, the treatment needs of multiple blood treatment modes can be completed without replacing the set of pipelines, and there is no need to frequently replace the pipelines; and when changing patients, the previously unused pipelines do not need to be removed, and only the used tubes need to be replaced to re-form a set of pipelines that can be applicable to multiple treatment modes. It can be seen that the pipeline system provided by the present application can significantly improve the convenience of blood treatment, is easy to install and use, simplifies the pipeline installation operation, reduces installation errors, and is also conducive to saving preparation time before treatment and ensuring the life of patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 The figure shows a schematic diagram of the structure of a part of the basic medicine liquid pipe of the pipeline system in the embodiment of the present application;

[0029] Figure 2 Shown is a schematic diagram of the pipelines of eight treatment modes in hemodialysis and filtration in the embodiments of the present application;

[0030] Figure 3 Shown is a schematic diagram of the pipeline of the plasma filtration dialysis mode in the embodiment of the present application;

[0031] Figure 4 Shown is a schematic diagram of the pipeline of the dual plasma molecule adsorption system mode in the embodiment of the present application;

[0032] Figure 5 Shown is a schematic diagram of the pipeline of the paired plasma filtration adsorption mode in the embodiment of the present application;

[0033] Figure 6 Shown is a schematic diagram of the pipeline of the plasma separation adsorption system mode in the embodiment of the present application;

[0034] Figure 7 Shown is a schematic diagram of the pipeline of the molecular adsorption recycling system mode in the embodiment of the present application;

[0035] Figure 8 Shown is a schematic diagram of the pipeline of the double filtration plasma exchange mode in the embodiment of the present application.

[0036] Figure 1-Figure 8 middle:

[0037] 10. Blood basic tube; 11. Blood collection basic tube; 12. Blood return basic tube; 20. Waste liquid basic tube;

[0038] 31, first liquid medicine basic tube; 311, first main tube; 312, first branch tube; 313, second branch tube; 32, second liquid medicine basic tube; 321, second main tube; 322, third branch tube; 323, fourth branch tube; 33, third liquid medicine basic tube; 34, fourth liquid medicine basic tube; 35, fifth liquid medicine basic tube;

[0039] 41. First connecting pipe; 42. Second connecting pipe; 421. Third main pipe; 422. Fifth branch pipe; 423. Sixth branch pipe; 43. Third connecting pipe; 44. Fourth connecting pipe; 45. Fifth connecting pipe. DETAILED DESCRIPTION

[0040] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0041] Please refer to the attached Figure 1-Figure 8 , an embodiment of the present application provides a pipeline system for realizing multiple blood treatment modes, and the pipeline system is suitable for blood treatment equipment. The pipeline system includes multiple tubes, each of which is provided with multiple input connectors and output connectors for connecting or splitting with any other tubes. Multiple tubes form a blood passage and a liquid medicine passage, and the blood passage and the liquid medicine passage need to be connected to an external therapeutic device such as a dialyzer, an adsorber, a plasma separator, etc., and a pump needs to be configured to provide liquid delivery power, so that blood and liquid medicine can flow through the external therapeutic device and perform hemodialysis, filtration and other treatments through the external therapeutic device. The blood after treatment flows back to the human body, and the waste liquid flows to the waste liquid bag. The blood passage includes a blood collection basic tube 11 for connecting to the input end of the external therapeutic device and a blood return basic tube 12 for connecting to the output end of the external therapeutic device; the liquid medicine passage includes a waste liquid basic tube 20 for connecting to the output end of the external therapeutic device, and multiple liquid medicine basic tubes for connecting to the external therapeutic device or the blood passage. By using this set of pipelines with multiple drug solution basal tubes and blood basal tubes in combination and adjusting the connection relationship and conductivity between the various tubes, for example, by using pipeline valves configured on some of the drug solution basal tubes to switch the conductivity of multiple drug solution basal tubes, multiple liquid flow paths can be formed, thereby responding to the liquid flow requirements of multiple treatment modes and completing the treatment requirements of multiple blood treatment modes without replacing the complete set of pipelines.

[0042] Specifically, after the pipeline is applied to the blood treatment equipment, the pipeline needs to be used in conjunction with the pump on the blood treatment equipment, and the pump is used to provide conveying power for the liquid in the pipeline. For example, in this article, the pump configured on the blood pathway to provide conveying power for blood is called a blood pump, the pump that provides power for the liquid in the waste liquid base tube 20 is called a waste liquid pump, and the pump used on the drug liquid base tube to provide conveying power for the drug liquid is called a drug liquid pump. At the same time, the blood treatment equipment will also be provided with a pipeline valve to turn on or off the tube and adjust the conduction of the tube. After different liquid flow paths are formed by adjusting the conduction conditions or connection relationships of each tube, the corresponding pump is started to work, and the corresponding mode of blood treatment can be achieved.

[0043] It can be seen that the pipeline system provided by the present application is a pipeline with multiple conduction paths formed by connecting multiple tubes to each other. Different liquid flow paths can be formed by switching different conduction conditions through the pipeline valve on the regulating device used to regulate the pipeline, corresponding to the liquid flow requirements of various blood treatment modes. Then, the same set of pipelines is suitable for various blood treatment modes. Installing this set of pipeline system on the blood treatment device can meet the treatment needs of various blood treatment modes. When these treatment modes are needed, it is only necessary to install this set of pipelines, which reduces the error rate in installing the pipelines, simplifies the pipeline installation operation, and improves the convenience of use; and when the same patient needs to change the blood treatment mode, there is no need to replace the pipeline. It is only necessary to switch the conduction conditions of each tube to form the required liquid flow path. Then, the treatment needs of various blood treatment modes can be met without replacing the complete set of pipelines, and there is no need to frequently replace the pipelines; and when changing patients, the previously unused pipelines do not need to be removed, and only the used tubes need to be replaced to re-form a set of pipelines that can be suitable for various treatment modes. It can be seen that the pipeline system provided by the present application can significantly improve the convenience of blood treatment, facilitate installation and use, simplify pipeline installation and operation, reduce installation errors, and also help save preparation time before treatment and protect the patient's life.

[0044] In actual applications, the path switching of the pipeline system can be executed by the controller on the blood treatment equipment. By inputting instructions, the controller can automatically adjust the operating status of each pump and the on-off status of the pipeline valve to the tube, and completely switch the liquid flow path and treatment mode. After the pipeline system adopted in this application is set on the blood treatment equipment, it is very convenient to implement blood treatment operations in various modes.

[0045] In summary, the liquid medicine pathway may include two or three or four or five liquid medicine basic tubes. Correspondingly, the number of liquid medicine basic tubes included is different, and the number of blood treatment modes that can be realized is also different; the more liquid medicine basic tubes there are, the more blood treatment modes that can be realized. When the liquid medicine pathway includes three liquid medicine basic tubes with different functions, namely, the first liquid medicine basic tube 31, the second liquid medicine basic tube 32 and the third liquid medicine basic tube 33, in cooperation with the blood pathway, nine blood treatment modes in terms of hemodialysis and filtration can be realized; when the liquid medicine pathway includes the fourth liquid medicine basic tube 34 and the fifth liquid medicine basic tube 35, and includes a plurality of connecting tubes corresponding to the external therapeutic device, in cooperation with the blood pathway, ten more blood in terms of ten plasma treatments can be realized. In this way, when the liquid medicine pathway includes the above-mentioned five liquid medicine basic tubes and a plurality of connecting tubes, nineteen blood treatment modes can be realized more conveniently.

[0046] Specifically, one end of the blood collection basic tube 11 is used to connect to the puncture needle on the patient, and the other end is used to connect to the input connector of the external treatment device, and one end of the blood return basic tube 12 is used to connect to the output connector of the external treatment device, and the other end is used to connect to the return puncture needle on the patient. The blood basic tube 10 is used to transport blood through the external treatment device, that is, through the power of the blood pump, the blood drawn from the human body is sent to the external treatment device, and then the treated blood is transported back to the human body.

[0047] When the external therapeutic device on the blood pathway is set as a perfusion device, the blood perfusion treatment mode can be realized. In the blood perfusion mode, the perfusion device is connected between the blood collection basic tube 11 and the blood return basic tube 12. After the blood is drawn out of the human body, it is pumped by the blood pump 4, flows into the perfusion device, and then flows into the blood return basic tube 12, and then flows back to the human body.

[0048] In the liquid medicine passage, one end of the waste liquid basic tube 20 is connected to the output connector of the external therapeutic device, and the other end is connected to the waste liquid bag containing the waste liquid, so as to transport the waste liquid discharged from the external therapeutic device into the waste liquid bag. The waste liquid basic tube 20 is always connected to the output end of the external therapeutic device and connected to the output connector of the external therapeutic device (the external therapeutic device has multiple input connectors and multiple output connectors). When there are two or more external therapeutic devices, the waste liquid basic tube 20 is connected to the external therapeutic device that finally outputs the waste liquid.

[0049] The waste liquid basic tube 20 and the blood basic tube 10 are combined to form a liquid flow path of the slow continuous ultrafiltration treatment mode. That is, the blood basic tube 10 is connected to the external treatment device A, i.e., the dialyzer, and the waste liquid basic tube 20 is connected to the output connector of the dialyzer, and the blood pump 4 and the waste liquid pump 5 are started, so that the slow continuous ultrafiltration mode can be realized.

[0050] The basic tube for liquid medicine includes a first basic tube for liquid medicine 31. In the present application, the first basic tube for liquid medicine 31 can deliver liquid medicine to any one or any combination of the external treatment device, the basic tube for blood collection 11, and the basic tube for blood return 12. Specifically, the first basic tube for liquid medicine 31 is configured as follows: the first basic tube for liquid medicine 31 includes a first main tube 311 for connecting to a liquid medicine bag and a first branch tube 312 and a second branch tube 313 both connected to the first main tube 311, the first branch tube 312 is used to connect to the external treatment device, and the second branch tube 313 is used to connect to the input connector of the basic tube for blood collection 11 or the basic tube for blood return 12.

[0051] In this way, the first medicine liquid basic tube 31 can deliver medicine liquid to any one of the three, or any combination, of the external treatment device, the blood collection basic tube 11 upstream of the external treatment device, and the blood return basic tube 12 downstream of the external treatment device. Only through the cooperation of the first medicine liquid basic tube 31, the waste liquid basic tube 20 and the blood passage, three treatment modes can be realized, namely, dilution before blood filtration (abbreviated as CVVH-pre), dilution after blood filtration (abbreviated as CVVH-post) and hemodialysis (abbreviated as CVVHD). When other medicine liquid basic tubes are also provided in the medicine liquid passage, more treatment modes can be realized in combination with other medicine liquid basic tubes.

[0052] It should be noted that the external therapeutic device is usually a dialyzer, a plasma separator, an adsorber, etc., which can be called external therapeutic device A, external therapeutic device B, external therapeutic device C, etc. The cavity of each external therapeutic device is divided into two sides by a semipermeable membrane, one can be called the blood side, and the other can be called the dialysis side. In each treatment mode, the blood collection basic tube 11 and the blood return basic tube 12 are both connected to the blood side, and the drug liquid basic tube and the waste liquid basic tube 20 are both connected to the dialysis side; if the drug liquid flows directly into the blood collection basic tube 11 through the drug liquid basic tube, the drug liquid is mixed with the blood to be treated and enters the blood side together, and the drug liquid that directly enters the external therapeutic device through the drug liquid basic tube enters the dialysis side. If the drug liquid flows directly into the blood return basic tube 12 through the drug liquid basic tube, the drug liquid is mixed with the blood after treatment and flows back to the human body together.

[0053] There are three treatment modes: dilution before blood filtration, dilution after blood filtration and hemodialysis. In the three modes, the external therapeutic device is a dialyzer, which can be called an external therapeutic device A. It can be a conventional external therapeutic device A or a high-pass external therapeutic device A, which is collectively referred to as an external therapeutic device A in this article. In the blood pathway, the external therapeutic device A is connected between the blood collection basic tube 11 and the blood return basic tube 12.

[0054] The above slow continuous ultrafiltration mode is recorded as the first mode. The following sequentially describes the flow paths of the fluids in various treatment modes that can be formed by the pipeline system provided by the present application.

[0055] The second mode: the second branch tube 313 is turned on, the first branch tube 312 is turned off, and the second branch tube 313 is connected to the blood collection basic tube 11 (i.e., the end of the second branch tube 313 is connected to an input connector of the blood collection basic tube 11). In this way, the liquid flow path of the pre-hemofiltration dilution mode can be realized. In this mode, blood is drawn out from the human body and flows into the blood collection basic tube 11, and is pumped by the blood pump into the external treatment device A; the liquid medicine flows into the blood collection basic tube 11 through the first main tube 311 and the second branch tube 313, and flows into the external treatment device A together with the blood. After being treated by the external treatment device A, the blood flows back to the human body through the blood return basic tube 12, and the waste liquid flows into the waste liquid basic tube 20 through the external treatment device A, and flows into the waste liquid bag through the waste liquid basic tube 20.

[0056] The third mode: the second branch tube 313 is turned on, the first branch tube 312 is turned off, and the second branch tube 313 is connected to the blood return basic tube 12, that is, a liquid flow path of the blood filtration post-dilution mode is formed. In this mode, blood is drawn out from the human body and flows into the blood collection basic tube 11, and then flows into the blood return basic tube 12 after passing through the external treatment device A; and the liquid medicine flows into the blood return basic tube 12 through the first main tube 311 and the second branch tube 313, and flows back to the human body together with the blood after dialyzation.

[0057] The fourth mode: the first branch tube 312 is turned on and the second branch tube 313 is turned off, so that the liquid flow path of the hemodialysis mode can be realized. The medicinal liquid flows into the external treatment device A through the first main tube 311 and the first branch tube 312, and undergoes a dialysis reaction with the blood flowing into the external treatment device A through the blood collection basic tube 11. Then, the waste liquid enters the waste liquid basic tube 20, and the dialyzed blood flows into the blood return basic tube 12.

[0058] The liquid medicine passage also includes a second liquid medicine basic tube 32. In the present application, the second liquid medicine basic tube 32 introduces liquid medicine from the first liquid medicine basic tube 31 and can transport liquid medicine to the blood collection basic tube 11 upstream of the external treatment device and / or the blood return basic tube 12 downstream of the external treatment device.

[0059] Specifically, the second medical liquid basic tube 32 includes a second main tube 321 and a third branch tube 322 and a fourth branch tube 323 connected to the second main tube 321. The second main tube 321 is connected to the first main tube 311 through a joint, for example, connected to the liquid outlet side branch of the first main tube 311. The third branch tube 322 is connected to the second branch tube 313 so as to be connected to the input joint of the blood collection basic tube 11 through the second branch tube 313. The fourth branch tube 323 is used to be connected to the input joint on the blood collection basic tube 11 or the blood return basic tube 12. By selectively conducting the third branch tube 322 or the fourth branch tube 323, and switching the fourth branch tube 323 to be connected to the blood collection basic tube 11 or the blood return basic tube 12, the liquid flow paths of the three treatment modes of pre-hemofiltration and post-hemofiltration mixing dilution, pre-hemodiafiltration dilution, and post-hemodiafiltration dilution can be formed.

[0060] Specifically, the fifth mode: the second branch tube 313 is turned on and the second branch tube 313 is connected to the blood return basic tube 12, the fourth branch tube 323 is turned on and the fourth branch tube 323 is connected to the blood collection basic tube 11, and the second branch tube 313 and the third branch tube 322 are turned off, so as to form a liquid flow path of the pre- and post-blood filtration mixed dilution mode; in this mode, the blood flows through the blood collection basic tube 11, the external treatment device A and the blood return basic tube 12 in sequence, and the drug liquid is divided into two paths through the first main tube 311, one path flows into the blood return basic tube 12 through the second branch tube 313, and the other path flows into the second main tube 321 of the second drug liquid basic tube 32 and flows into the blood collection basic tube 11 through the fourth branch tube 323.

[0061] The sixth mode: the first branch tube 312 and the fourth branch tube 323 are turned on, the second branch tube 313 and the third branch tube 322 are turned off, the fourth branch tube 323 is connected to the blood sampling basic tube 11, and the liquid medicine is divided into two paths through the first main tube 311, one path flows directly into the external treatment device A through the first branch tube 312, and the other path flows into the second main tube 321 of the second liquid medicine basic tube 32 and flows into the blood sampling basic tube 11 through the fourth branch tube 323, and then flows into the external treatment device A together after mixing with the blood, thus forming a liquid flow path of the dilution mode before hemodiafiltration; or, the first branch tube 312, the second branch tube 313 and the third branch tube 322 are turned on, the liquid medicine is divided into two paths through the first main tube 311, and the first branch tube 312 ... The branch tube 313 and the third branch tube 322 are both connected, the second branch tube 313 is connected to the blood collection basic tube 11, the fourth branch tube 323 is connected to the blood return basic tube 12, and the medicine is divided into three paths through the first main tube 311. One path flows into the external treatment device A through the first branch tube 312, the second path flows into the second branch tube 313, and the third path flows into the second medicine basic tube 32 and merges into the second branch tube 313 through the third branch tube 322. The medicine through the second branch tube 313 flows into the blood collection basic tube 11 and mixes with the blood to enter the external treatment device A. In this way, the liquid flow path of the dilution mode before hemodialysis filtration can also be realized.

[0062] The seventh mode: the first branch tube 312 and the fourth branch tube 323 are turned on, the second branch tube 313 and the third branch tube 322 are turned off, and the fourth branch tube 323 is connected to the blood return basic tube 12. The drug solution is divided into two paths through the first main tube 311, one path flows into the external treatment device A through the first branch tube 312, and the other path flows into the blood return basic tube 12 through the fourth branch tube 323, thereby realizing the liquid flow path of the dilution mode after hemodialysis filtration.

[0063] Furthermore, the liquid medicine passage also includes a third liquid medicine basic tube 33. One end of the third liquid medicine basic tube 33 is connected to the first liquid medicine basic tube 31 through a joint (specifically, connected to the liquid outlet side branch of the first main tube 311), and the other end is connected to the input joint of the blood collection basic tube 11. The third liquid medicine basic tube 33 drains liquid medicine from the first liquid medicine basic tube 31 and can deliver liquid medicine to the blood collection basic tube 11.

[0064] The eighth mode: the first branch pipe 312 and the fourth branch pipe 323 are selected to be connected, the second branch pipe 313 and the third branch pipe 322 are closed, and the fourth branch pipe 323 is connected to the blood return basic pipe 12, so that a liquid flow path of the hemodialysis filtration pre-post mixing dilution treatment mode can be formed; in this mode, the liquid medicine is divided into three paths through the first main pipe 311, one path flows into the external treatment device A through the first branch pipe 312, the second path flows into the blood return basic pipe 12 through the fourth branch pipe 323, and mixes with the blood flowing out of the external treatment device A and flows into the human body together, and the third path flows into the blood collection basic pipe 11 through the third liquid medicine basic pipe 33, and mixes with the blood that has not been dialyzed and flows into the external treatment device A together. That is, in this mode, the first liquid pump 1 is used to input liquid medicine into the external treatment device A, the second liquid pump 2 is used to input liquid medicine into the blood return basic pipe 12 downstream of the external treatment device A, and the third liquid pump 3 is used to input liquid medicine into the blood collection basic pipe 11 upstream of the external treatment device A.

[0065] In summary, by setting the above-mentioned three basic tubes for medical liquid, the three basic tubes for medical liquid are combined with the basic tube for blood collection 11 and the basic tube for waste liquid 20, and by switching the conduction conditions, eight treatment modes of hemodialysis and filtration can be realized. Combined with the blood perfusion mode, nine blood treatment modes can be realized.

[0066] In the eight treatment modes of hemodialysis and filtration, an external therapeutic device is provided for each of them, and each of them is arranged between the blood collection basic tube 11 and the blood return basic tube 12, and the waste liquid basic tube 20 is always connected to the output end of the external therapeutic device.

[0067] In some embodiments, the drug liquid passage includes a fourth drug liquid basic tube 34. One end of the fourth drug liquid basic tube 34 is used to connect to the drug liquid bag, and the other end is used to connect to the input connector of the external treatment device or the blood return basic tube 12. The fourth drug liquid basic tube 34 is used to transport the drug liquid to the external treatment device or the blood return basic tube 12. That is, in actual use, the fourth drug liquid basic tube 34 and the first drug liquid basic tube 31 are used alternatively, and the two use the same liquid pump to transport the liquid. It can also be said that the fourth drug liquid basic tube 34 can replace the first drug liquid basic tube 31. For example, the first drug liquid basic tube 31 connected to the first liquid pump is removed, and the fourth drug liquid basic tube 34 is connected to the first liquid pump and the first liquid pump provides the liquid transportation power. In other words, the first drug liquid basic tube 31 and the fourth drug liquid basic tube 34 are alternately and optionally configured on the blood treatment device.

[0068] By combining the blood basal tube 10, the waste liquid basal tube 20, the fourth drug liquid basal tube 34 and the external therapeutic device, and selecting whether the drug liquid bag and the waste liquid bag are connected and selecting the output position of the fourth drug liquid basal tube 34, the liquid flow paths of three treatment modes of repeated albumin dialysis (RAD for short), single pass albumin dialysis (SPAD for short), and plasma exchange (PE for short) can be formed, which can be recorded as the ninth mode, the tenth mode and the eleventh mode.

[0069] In the single-pass albumin dialysis and repeated albumin dialysis treatment modes, the fourth liquid medicine base tube 34 is connected to the external therapeutic device A-dialyzer to input the liquid medicine into the external therapeutic device A. The difference is that in the repeated albumin dialysis treatment mode, the waste liquid bag and the liquid medicine bag are connected, and the liquid medicine is reused, while in the single-pass albumin dialysis, the waste liquid bag and the liquid medicine bag are not connected. In the plasma exchange treatment mode, the external therapeutic device is the external therapeutic device B-plasma separator, and the fourth liquid medicine base tube 34 is connected to the blood return base tube 12; after the blood flows into the external therapeutic device B through the blood collection base tube 11, the separated plasma with pathogenic factors flows into the waste liquid bag through the waste liquid base tube 20, and the fourth liquid medicine base tube 34 inputs the new plasma into the blood return base tube 12, and the new plasma and the treated blood are mixed and returned to the human body.

[0070] In some embodiments, the liquid medicine passage further includes a fifth liquid medicine basic tube 35, which is used to transport liquid medicine to the blood return basic tube 12, or to transport blood in the first external treatment device to the second external treatment device. That is, in actual use, the fifth liquid medicine basic tube 35 and the second liquid medicine basic tube 32 are used selectively, and the two use the same liquid pump to transport liquid, such as both can be detachably connected to the second liquid pump, and the second liquid pump provides the transport power. In other words, the second liquid medicine basic tube 32 and the fifth liquid medicine basic tube 35 are alternately and optionally configured on the blood treatment device.

[0071] One end of the fifth drug solution basic tube 35 is used to be connected to the drug solution bag, and the other end is used to be connected to the input connector of the blood return basic tube 12, or one end is used to be connected to the first external therapeutic device, and the other end is used to be connected to the second external therapeutic device. Usually, the first external therapeutic device is an external therapeutic device B-plasma separator, and the second external therapeutic device is an external therapeutic device A-dialyzer or an external therapeutic device C-adsorbent.

[0072] Twelfth mode: an external therapeutic device D-plasma component separator is set on the blood base tube 10, one end of the fifth drug liquid base tube 35 is connected to the drug liquid bag, and the other end is connected to the blood return base tube 12; the first liquid pump 1, the second liquid pump 2, the blood pump 4 and the waste liquid pump 5 are started, and the liquid flow path of the plasma filtration dialysis mode (abbreviated as PDF) can be formed through the combination of the external therapeutic device, the blood base tube 10, the waste liquid base tube 20, the fourth drug liquid base tube 34 and the fifth drug liquid base tube 35. That is, in the plasma filtration dialysis mode, the external therapeutic device is the external therapeutic device D-plasma component separator, blood flows through the blood base tube 10 through the external therapeutic device, the drug liquid flows through the fourth drug liquid base tube 34 through the external therapeutic device, and then flows into the waste liquid base tube 20, and new plasma is supplemented into the blood return base tube 12 through the fifth drug liquid base tube 35.

[0073] In a further embodiment, the liquid medicine passage is further provided with a plurality of connecting tubes for corresponding connection with the external therapeutic device, and by switching the connecting tubes, the basic tube and the connecting tube can be combined into a liquid flow path of a plurality of blood treatment modes. Usually, the type of the external therapeutic device in the treatment mode is determined, so that each connecting tube is used in conjunction with a specified type of external therapeutic device, that is, the exclusive role of each connecting tube is clarified, and when assembling the pipeline, the connection operation can be simplified, and the pipeline installation error can be reduced.

[0074] The connection pipes include a first connection pipe 41 , a second connection pipe 42 , and a plurality of auxiliary connection pipes.

[0075] The first connecting tube 41 is used to connect to the input end of the external therapeutic device C-adsorber, and is used to connect the external therapeutic device C to the pipeline and connect to other external therapeutic devices or basic tubes. For example, one end of the first connecting tube 41 is connected to the input end of the external therapeutic device C, and the other end is used to connect to the fifth liquid basic tube 35 or the external therapeutic device A.

[0076] The second connecting tube 42 is connected to the output end of the external therapeutic device C, and is used to transport the adsorbed blood back to other external therapeutic devices or the blood return basic tube 12. Specifically, the second connecting tube 42 includes a third main tube 421 and a fifth branch tube 422 and a sixth branch tube 423 connected to the third main tube 421, the third main tube 421 is used to connect the output end of the external therapeutic device C, the fifth branch tube 422 is used to connect to the input connector of the blood return basic tube 12, and the sixth branch tube 423 is used to connect to other external therapeutic devices such as the first external therapeutic device or the second external therapeutic device connected in the pipeline.

[0077] There are multiple auxiliary connecting tubes, which are used to connect two external therapeutic devices or to connect an external therapeutic device and a basic tube. For example, there may be three auxiliary connecting tubes, namely a third connecting tube 43, a fourth connecting tube 44 and a fifth connecting tube 45. These connecting tubes are used to connect between two external therapeutic devices, connect the two external therapeutic devices, and deliver the liquid output by the first external therapeutic device to the second external therapeutic device. For example, the third connecting tube 43 is used to connect two external therapeutic devices C; the fourth connecting tube 44 is used to connect two external therapeutic devices A or to connect external therapeutic device B and external therapeutic device A; the fifth connecting tube 45 is used to connect the external therapeutic device D-plasma component separator and the fourth liquid basic tube 34 (see the specific description in each mode below).

[0078] By switching and combining the above-mentioned connecting tube and the fourth medical solution basic tube 34 and the fifth medical solution basic tube 35, liquid flow paths of various treatment modes can be formed, as described in detail below.

[0079] Thirteenth mode: using an external therapeutic device B and an external therapeutic device C, the external therapeutic device B is connected between the blood collection basic tube 11 and the blood return basic tube 12, the external therapeutic device C is connected between the first connecting tube 41 and the second connecting tube 42, the first connecting tube 41 is connected to the input end of the external therapeutic device C, the second connecting tube 42 is connected to the output end of the external therapeutic device C, one end of the fifth liquid medicine basic tube 35 is connected to the output connector of the external therapeutic device B, the other end is connected to the first connecting tube 41, and the second connecting tube 42 is connected to the input connector of the blood return basic tube 12; such a setting can form a liquid flow path of the plasma adsorption therapy mode (abbreviated as PA). In this mode, blood is divided into two paths through the external therapeutic device B, the first path flows into the blood return basic tube 12, and the second path is separated and flows into the external therapeutic device C through the fifth liquid medicine basic tube 35 for adsorption and purification, and then flows into the blood return basic tube 12 and merges with the first path.

[0080] Fourteenth mode: Further, an external therapeutic device C is added to the pipeline of the plasma adsorption treatment mode, and the two external therapeutic devices C are connected through the third connecting tube 43, that is, the two ends of the third connecting tube 43 are respectively connected to the output end of the first external therapeutic device C and the input end of the second external therapeutic device C, and the remaining pipeline settings are the same as those of the plasma adsorption treatment mode, that is, the liquid flow path of the dual plasma molecular adsorption system (DPMAS) treatment mode can be realized, such as Figure 4 shown.

[0081] By using the fourth medical liquid basic tube 34, the fifth medical liquid basic tube 35, the second connecting tube 42 and the fourth connecting tube 44, in combination with the external therapeutic device B, the external therapeutic device A and the external therapeutic device C, and adjusting the number of external therapeutic devices C and the conductivity of the fifth branch tube 422 and the sixth branch tube 423, liquid flow paths for three treatment modes can be formed, namely paired plasma filtration adsorption (CPFA for short), plasma separation adsorption system (FPSA for short) and molecular adsorption recirculation (MARS for short).

[0082] The fifteenth mode: Figure 5As shown, the external therapeutic device B is arranged between the blood collection basic tube 11 and the fourth connecting tube 44, the external therapeutic device A is arranged between the fourth connecting tube 44 and the blood return basic tube 12, one end of the fifth drug liquid basic tube 35 is connected to the output end of the external therapeutic device B, and the other end is connected to the first connecting tube 41 of the input end of the external therapeutic device C, the output end of the external therapeutic device C is the second connecting tube 42, the sixth branch tube 423 of the second connecting tube 42 is connected and connected to the fourth connecting tube 44, and the fifth branch tube 422 is closed; the blood is separated by the external therapeutic device B, and the separated plasma flows through the fifth drug liquid basic tube 35, the external therapeutic device C, and the second connecting tube 42 in sequence, flows into the fourth connecting tube 44 through the second connecting tube 42, and mixes with the blood output by the external therapeutic device B and flows into the external therapeutic device A together, while the drug liquid flows into the external therapeutic device A through the fourth drug liquid basic tube 34, and then flows to the waste liquid bag through the waste liquid basic tube 20, so as to realize the liquid flow path of the paired plasma filtration adsorption mode.

[0083] The sixteenth mode: Figure 6 As shown, the external therapeutic device B is arranged between the blood collection basic tube 11 and the fourth connecting tube 44, the external therapeutic device A is arranged between the fourth connecting tube 44 and the blood return basic tube 12, one end of the fifth liquid medicine basic tube 35 is connected to the output connector of the separation side of the external therapeutic device B, and the other end is connected to the first connecting tube 41 of the input end of the first external therapeutic device C, the first external therapeutic device C and the second external therapeutic device C are connected through the third connecting tube 43, the output end of the second external therapeutic device C is the second connecting tube 42, the sixth branch 423 of the second connecting tube 42 is connected and connected to the input connector of the external therapeutic device B; the plasma separated by the external therapeutic device B flows through the two external therapeutic devices C in sequence through the fifth liquid medicine basic tube 35 and then flows back to the external therapeutic device B. In this way, the liquid flow path of the plasma separation and adsorption system mode is realized.

[0084] The seventeenth mode: Figure 7 As shown, the first external therapeutic device A is arranged between the blood collection basic tube 11 and the blood return basic tube 12, the second external therapeutic device A is arranged between the fourth liquid medicine basic tube 34 and the waste liquid basic tube 20, one end of the fifth liquid medicine basic tube 35 is connected to the output end of the dialysis side of the first external therapeutic device A, and the other end is connected to the input end of the blood side of the second external therapeutic device A, the first external therapeutic device C is connected to the output end of the blood side of the second external therapeutic device A through the first connecting tube 41, and the second external therapeutic device C is connected to the input end of the dialysis side of the first external therapeutic device A through the second connecting tube 42; the blood is separated by the first external therapeutic device A, and the liquid dialyzed by the first external therapeutic device A flows into the second external therapeutic device A through the fifth liquid medicine basic tube 35, reacts with the dialysate, and flows out of the second external therapeutic device A and then flows through the two external therapeutic devices C in sequence and then flows back to the first external therapeutic device A; in this way, the liquid flow path of the molecular adsorption recycling system mode is realized.

[0085] By using an external treatment device B, a plasma component separator, and combining the blood basic tube 10, the waste liquid basic tube 20, the fourth drug liquid basic tube 34, the fifth drug liquid basic tube 35 and the fifth connecting tube 45, a liquid flow path of a double filtration plasma exchange (DFPP for short) mode can be formed.

[0086] The eighteenth mode is also a double filtration plasma exchange mode: Figure 8 As shown, the external therapeutic device B is connected between the blood collection basic tube 11 and the blood return basic tube 12, one end of the fifth liquid medicine basic tube 35 is connected to the output end of the separation side of the external therapeutic device B, and the other end is connected to the input end of the blood side of the external therapeutic device D-plasma component separator, one end of the fifth connecting tube 45 is connected to the output end of the blood side of the plasma component separator, and the other end is connected to the fourth liquid medicine basic tube 34, the fourth liquid medicine basic tube 34 is connected to the blood return basic tube 12, and the waste liquid basic tube 20 is connected to the output end of the separation side of the external therapeutic device D; the plasma separated by the external therapeutic device B enters the plasma component separator through the fifth liquid medicine basic tube 35 for further separation, and the plasma in the external therapeutic device D after further separation flows back to the blood return basic tube 12 through the fifth connecting tube 45 and the fourth liquid medicine basic tube 34, and the waste liquid output by the external therapeutic device D flows into the waste liquid bag through the waste liquid basic tube 20.

[0087] In summary, it can be seen that in the present application, the liquid medicine passage includes a plurality of basic tubes and a plurality of connecting tubes, and the connecting tubes are arranged corresponding to the external therapeutic device, and are used to connect two external therapeutic devices or connect the external therapeutic device to the basic tubes. The basic tubes and the basic tubes and the connecting tubes can be used in combination with each other to form liquid flow paths of multiple treatment modes.

[0088] Among them, some basic tubes are connected (a first drug liquid basic tube, a second drug liquid basic tube, a third drug liquid basic tube, a waste liquid basic tube and a blood basic tube) and are combined with an external therapeutic device to form a plurality of liquid flow paths. By regulating the connection and conduction between these basic tubes, liquid flow paths of various treatment modes can be realized, meeting the pipeline requirements of various treatment modes, such as eight modes of hemodialysis filtration; and some basic tubes and connecting tubes (a fourth drug liquid basic tube, a fifth drug liquid basic tube, a waste liquid basic tube, a blood basic tube and the above-mentioned connecting tubes) are used in combination according to the required external therapeutic device. By changing the connection position of the basic tubes and the connecting tubes and the external therapeutic device connected to the basic tubes, the basic tubes and the connecting tubes are combined with each other to form liquid flow paths of various treatment modes, so as to match other multiple treatment modes, such as ten modes of plasma treatment, combined with the blood perfusion mode that can be achieved through the blood basic tube 10. In the best embodiment, the pipeline system provided by the present application can achieve nineteen treatment modes when it has a blood basic tube, a waste liquid basic tube, five drug liquid basic tubes and multiple connecting tubes.

[0089] The nineteen treatment modes included pre-hemofiltration dilution, post-hemofiltration dilution, pre- and post-hemofiltration mixed dilution, hemodialysis, pre-hemodiafiltration dilution, post-hemodiafiltration dilution, hemodiafiltration mixed dilution, slow continuous ultrafiltration, hemoperfusion, plasmapheresis, dual filtration plasmapheresis, paired plasmafiltration adsorption, plasma adsorption, dual plasma molecular adsorption system, molecular adsorption recirculation system, plasma separation adsorption system, single-pass albumin dialysis, repeated albumin dialysis, and plasmafiltration dialysis.

[0090] Applying the pipeline system provided by the present application to a blood treatment device can integrate multiple blood treatment modes on the blood treatment device, with high integration and easy use. At the same time, the multiple tubes in the pipeline system are classified and functionally arranged, and the functions of each tube are clear. Each tube has its own matching connection object, which not only has an exclusive fixed position on the device body, which is convenient for disassembly and fixation, but also corresponds to the combination of each mode. The use is very clear and easy to set, which is conducive to improving the convenience of switching the pipeline when changing the mode; and each tube with a clear function and set separately is relative to the standard part. When the treatment object of the blood treatment device changes, that is, when the patient is changed, the pipeline used by the previous patient can be directly replaced, and the pipeline not used by the previous patient can be retained and combined with the new pipeline, avoiding resource waste, saving costs, and improving the convenience of pipeline disassembly and replacement.

[0091] The basic principles of the present application are described above in conjunction with specific embodiments. However, it should be noted that the advantages, strengths, effects, etc. mentioned in the present application are only examples and not limitations, and it cannot be considered that these advantages, strengths, effects, etc. are required by each embodiment of the present application. In addition, the specific details disclosed above are only for the purpose of illustration and ease of understanding, not for limitation, and the above details do not limit the present application to being implemented by adopting the above specific details.

Claims

1. A pipeline system for realizing multiple blood treatment modes, characterized in that: comprising a plurality of tubes, wherein the plurality of tubes form a blood passage and a drug solution passage; The blood passage comprises a blood collection basic tube (11) for connecting to the input end of the external therapeutic device, and a blood return basic tube (12) for connecting to the output end of the external therapeutic device; The liquid medicine passage comprises a waste liquid basic tube (20) for connecting to the output end of the external therapeutic device, and a plurality of liquid medicine basic tubes for connecting to the external therapeutic device and / or the blood passage; By adjusting the connection relationship and conductance between the various tubes, a variety of fluid flow paths can be formed to correspond to a variety of treatment modes.

2. The pipeline system for realizing multiple blood treatment modes according to claim 1, characterized in that: The liquid medicine base tube comprises: The first liquid medicine basic tube (31) is capable of delivering liquid medicine to any one or any combination of the external treatment device, the blood collection basic tube (11), and the blood return basic tube (12); The second drug solution basic tube (32) is used to introduce drug solution from the first drug solution basic tube (31) and can transport the drug solution to the blood collection basic tube (11) and / or the blood return basic tube (12).

3. The pipeline system for realizing multiple blood treatment modes according to claim 2, characterized in that: The first medicine liquid basic tube (31) comprises a first main tube (311) for connecting to a medicine liquid bag, and a first branch tube (312) and a second branch tube (313) both connected to the first main tube (311), the first branch tube (312) being connected to the external therapeutic device, and the second branch tube (313) being connected to the blood collection basic tube (11) or the blood return basic tube (12); By selecting to conduct the first branch tube (312) or the second branch tube (313), and switching the second branch tube (313) to be connected to the blood collection basic tube (11) or the blood return basic tube (12), three flow paths for treatment modes can be formed.

4. The pipeline system for realizing multiple blood treatment modes according to claim 3, characterized in that: The three treatment modes are pre-hemofiltration dilution, post-hemofiltration dilution and hemodialysis. In the pre-blood filtration dilution mode, the second branch tube (313) is connected to the blood sampling basic tube (11), and the liquid medicine flows into the blood sampling basic tube (11) through the first main tube (311) and the second branch tube (313) and flows into the external therapeutic device together with the blood; In the post-hemofiltration dilution mode, the second branch tube (313) is connected to the blood return basic tube (12), and the liquid medicine flows into the blood return basic tube (12) through the first main tube (311) and the second branch tube (313) and flows back to the human body together with the dialyzed blood; In the hemodialysis mode, the first branch tube (312) is connected, and the drug solution flows into the external treatment device through the first main tube (311) and the first branch tube (312).

5. The pipeline system for realizing multiple blood treatment modes according to claim 3, characterized in that: The second medical liquid basic tube (32) comprises a second main tube (321) connected to the liquid outlet side branch of the first main tube (311), a third branch tube (322) and a fourth branch tube (323) both connected to the second main tube (321), the third branch tube (322) and the second branch tube (313) being connected to the blood collection basic tube (11) through the second branch tube (313), and the fourth branch tube (323) being used to be connected to the blood collection basic tube (11) or the blood return basic tube (12); By selectively conducting the third branch tube (322) or the fourth branch tube (323), and switching the fourth branch tube (323) to be connected to the blood collection basic tube (11) or the blood return basic tube (12), three other flow paths for treatment modes can be formed.

6. The pipeline system for realizing multiple blood treatment modes according to claim 5, characterized in that: The other three treatment modes are pre- and post-hemofiltration mixed dilution, pre-hemodiafiltration dilution, and post-hemodiafiltration dilution; In the pre- and post-hemofiltration mixed dilution mode, the second branch tube (313) is conducted and connected to the blood return basic tube (12), the fourth branch tube (323) is conducted and connected to the blood collection basic tube (11), and the liquid medicine is divided into two paths through the first main tube (311), one path flows into the blood return basic tube (12) through the second branch tube (313), and the other path flows into the second main tube (321) of the second liquid medicine basic tube (32) and flows into the blood collection basic tube (11) through the fourth branch tube (323); In the dilution mode before hemodiafiltration, the first branch tube (312) and the fourth branch tube (323) are connected, and the liquid medicine is divided into two paths through the first main tube (311), one path flows into the external treatment device through the first branch tube (312), and the other path flows into the second main tube (321) of the second liquid medicine basic tube (32) and flows into the blood collection basic tube (11) through the fourth branch tube (323); In the post-hemodiafiltration dilution mode, the first branch tube (312) is turned on, the fourth branch tube (323) is turned on and connected to the blood return basic tube (12), and the liquid medicine is divided into two paths through the first main tube (311), one path flows into the external treatment device through the first branch tube (312), and the other path flows into the blood return basic tube (12) through the fourth branch tube (323).

7. The pipeline system for realizing multiple blood treatment modes according to claim 2 or 5, characterized in that: The drug liquid basic tube also includes a third drug liquid basic tube (33); the third drug liquid basic tube (33) introduces drug liquid from the first drug liquid basic tube (31) and can transport drug liquid to the blood sampling basic tube (11); The first drug solution basic tube (31), the second drug solution basic tube (32) and the third drug solution basic tube (33) are connected, and by switching the conduction conditions of the three, a liquid flow path for multiple treatment modes in hemodialysis and hemofiltration can be formed.

8. The pipeline system for realizing multiple blood treatment modes according to claim 7, characterized in that: One end of the third medicine liquid basic tube (33) is connected to the liquid outlet side branch of the first main tube (311) of the first medicine liquid basic tube (31), and the other end is connected to the blood collection basic tube (11); By selectively conducting the first branch tube (312) of the second drug solution basic tube (32) and the fourth branch tube (323) of the second drug solution basic tube (32), a liquid flow path of a pre- and post-hemodiafiltration mixed dilution treatment mode can be formed.

9. The pipeline system for realizing multiple blood treatment modes according to claim 1, characterized in that: The medical liquid basic tube also includes a fourth medical liquid basic tube (34); One end of the fourth drug solution basic tube (34) is used to be connected to the drug solution bag, and the other end is used to be connected to the external treatment device or the blood return basic tube (12). By selecting whether the drug solution bag and the waste liquid bag are connected and selecting the output position of the fourth drug solution basic tube (34), the liquid flow paths of three treatment modes, namely repeated albumin dialysis, single-pass albumin dialysis, and plasma exchange, can be formed.

10. The pipeline system for realizing multiple blood treatment modes according to claim 9, characterized in that: The medical liquid basic tube also includes a fifth medical liquid basic tube (35) to form a liquid flow path of a plasma filtration dialysis mode by combining the blood collection basic tube (11), the waste liquid basic tube (20), the fourth medical liquid basic tube (34) and the fifth medical liquid basic tube (35); In the plasma filtration dialysis mode, one end of the fifth drug solution basic tube (35) is connected to the drug solution bag, and the other end is connected to the blood return basic tube (12).

11. The pipeline system for realizing multiple blood treatment modes according to claim 10, characterized in that: The drug solution passage is also provided with a plurality of connecting tubes for corresponding connection with an external therapeutic device. By switching and using the connecting tubes, the basic tube and the connecting tubes can be combined into a liquid flow path of a plurality of blood treatment modes.

12. The pipeline system for realizing multiple blood treatment modes according to claim 11, characterized in that: The connecting tube comprises a first connecting tube (41) for connecting to the input end of the external therapeutic device C, a second connecting tube (42) for connecting to the output end of the external therapeutic device C, and a third connecting tube (43) for connecting two external therapeutic devices C; The first connecting tube (41), the second connecting tube (42), and the third connecting tube (43) are combined with the fifth drug solution base tube (35) to form a liquid flow path in two treatment modes: plasma adsorption and dual plasma molecule adsorption system; In these two treatment modes, one end of the fifth medicine liquid basic tube (35) is connected to the output end of the external treatment device B arranged on the blood passage, and the other end is connected to the first connecting tube (41), and the second connecting tube (42) is connected to the blood return basic tube (12).

13. The pipeline system for realizing multiple blood treatment modes according to claim 12, characterized in that: The connecting tube further comprises a fourth connecting tube (44) for connecting two external therapeutic devices A or connecting the external therapeutic device B and the external therapeutic device A, and the second connecting tube (42) comprises a third main tube (421) and a fifth branch tube (422) and a sixth branch tube (423) both connected to the third main tube (421), the fifth branch tube (422) being used for connecting the blood return basic tube (12), and the sixth branch tube (423) being used for connecting the first external therapeutic device C or the second external therapeutic device C; By combining the fourth medical solution basic tube (34), the fifth medical solution basic tube (35), the second connecting tube (42) and the fourth connecting tube (44), and adjusting the number of external therapeutic devices C and the conductance between the fifth branch tube (422) and the sixth branch tube (423), liquid flow paths for three treatment modes, namely paired plasma filtration adsorption, plasma separation adsorption system and molecular adsorption recirculation, can be formed.

14. The pipeline system for realizing multiple blood treatment modes according to claim 13, characterized in that: In the paired plasma filtration adsorption mode, an external therapeutic device B is arranged between the blood collection basic tube (11) and the fourth connecting tube (44), an external therapeutic device A is arranged between the fourth connecting tube (44) and the blood return basic tube (12), one end of the fifth liquid medicine basic tube (35) is connected to the output end of the external therapeutic device B, and the other end is connected to the first connecting tube (41) on the external therapeutic device C, and the sixth branch tube (423) of the second connecting tube (42) on the external therapeutic device C is connected and connected to the fourth connecting tube (44); the plasma separated by the external therapeutic device B flows through the fifth liquid medicine basic tube (35) through an external therapeutic device C and then flows into the external therapeutic device A; In the plasma separation and adsorption system mode, an external therapeutic device B is arranged between the blood collection basic tube (11) and the fourth connecting tube (44), an external therapeutic device A is arranged between the fourth connecting tube (44) and the blood return basic tube (12), one end of the fifth liquid medicine basic tube (35) is connected to the output end of the external therapeutic device B, and the other end is connected to the first connecting tube (41) at the input end of the first external therapeutic device C, the first external therapeutic device C is connected to the second external therapeutic device C through the third connecting tube (43), the output end of the second external therapeutic device C is the second connecting tube (42), the sixth branch tube (423) of the second connecting tube (42) is connected to the external therapeutic device B, and the plasma separated by the external therapeutic device B flows through the fifth liquid medicine basic tube (35) through the two external therapeutic devices C in sequence and then flows back to the external therapeutic device B; In the molecular adsorption recirculation system mode, a first external therapeutic device A is arranged between the blood collection basic tube (11) and the blood return basic tube (12), a second external therapeutic device A is arranged between the fourth liquid medicine basic tube (34) and the waste liquid basic tube (20), one end of the fifth liquid medicine basic tube (35) is connected to the output end of the first external therapeutic device A, and the other end is connected to the input end of the second external therapeutic device A, a first external therapeutic device C is connected to the output end of the second external therapeutic device A through the first connecting tube (41), and the second external therapeutic device C is connected to the input end of the first external therapeutic device A through the second connecting tube (42), and the blood after dialyzation of the first external therapeutic device A flows into the second external therapeutic device A through the fifth liquid medicine basic tube (35), and after flowing out of the second external therapeutic device A, it flows through the two external therapeutic devices C in sequence and then flows back to the first external therapeutic device A.

15. The pipeline system for realizing multiple blood treatment modes according to claim 11, characterized in that: The connecting tube further comprises a fifth connecting tube (45) so as to form a liquid flow path of a double filtration plasma exchange mode by combining the waste liquid basic tube (20), the fourth medical liquid basic tube (34), the fifth medical liquid basic tube (35) and the fifth connecting tube (45); In the double filtration plasma exchange mode, the plasma separated by the external therapeutic device B enters the external therapeutic device D through the fifth medical solution basic tube (35) for further separation, and the plasma output by the external therapeutic device D flows back to the blood return basic tube (12) through the fifth connecting tube (45) and the fourth medical solution basic tube (34), and the output waste liquid flows into the waste liquid basic tube (20).

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