Preparation method of lung-chest qi guiding capsule

Abstract

The invention relates to the technical field of capsule preparation, in particular to a preparation method of a lung-chest qi guiding capsule, which comprises the following steps: step 1, preparing raw materials; step 2, extracting effective components; step 3, concentrating and drying; step 4, granulating the materials; step 5, filling capsules; and step 6, quality inspection and packaging. The extraction process is optimized, and proper solvent, extraction time, temperature and auxiliary extraction technology are adopted, so that the effective components in the medicinal materials can be more fully extracted, and the extraction efficiency and the effective component content of the medicine are improved, thereby enhancing the treatment effect of the medicine, facilitating production operation and quality control, improving the production efficiency and the product consistency, and reducing the production cost. And large-scale production, popularization and application are facilitated.

Description

Technical Field

[0001] The invention relates to the technical field of capsule preparation, and in particular to a method for preparing a lung and chest-soothing capsule. Background Art

[0002] Feixiong Shunqi Capsule is used to regulate lung and chest discomfort and is a capsule preparation that has the effect of regulating and smoothing qi. For example, it may have a certain effect on relieving and improving symptoms such as chest tightness, chest pain, coughing, and breathing difficulties caused by qi stagnation.

[0003] The traditional lung and chest shunqi capsules are complicated, cumbersome, and labor-intensive to prepare, and the qualified rate of finished products is low. The pill weight varies greatly. The dissolution time is too long and the drug cannot be absorbed, which affects the product quality and therapeutic effect. The extraction route is not scientifically designed according to the composition of the raw materials, resulting in poor extraction efficiency, waste of resources, and difficulty in fully exerting the efficacy of each medicinal material. Therefore, a preparation method for lung and chest shunqi capsules is proposed. Summary of the invention

[0004] In view of this, the present invention provides a preparation method of a lung and chest-soothing capsule to solve or alleviate the technical problems existing in the prior art and at least provide a beneficial option.

[0005] The technical solution of the present invention is achieved as follows: a preparation method of a lung and chest smoothing capsule comprises the following steps:

[0006] Step 1: Prepare raw materials;

[0007] Step 2: extracting active ingredients;

[0008] Step 3: Concentration and drying;

[0009] Step 4: granulating the materials;

[0010] Step 5: Capsule filling;

[0011] Step 6: Quality inspection and packaging.

[0012] Further preferably, in the step one, the required Chinese medicinal materials are purchased according to a predetermined formula, and the medicinal materials include costus root, tangerine peel, magnolia bark, green peel, cyperus rotundus, lindera strychnifolia, fructus aurantii, radish seed, perilla stem, areca catechu, platycodon grandiflorum, cardamom and liquorice, and a comprehensive quality inspection is carried out on each batch of purchased Chinese medicinal materials to ensure that the medicinal materials meet the standards.

[0013] Further preferably, in the step one, for the Chinese medicinal materials that need to be processed as specified in the formula, the traditional processing method is strictly followed, and the inspected and processed Chinese medicinal materials are crushed separately, using a medicinal material crusher, and according to the requirements of the extraction process, the Chinese medicinal materials are crushed into fine powder that can pass through an 80-mesh sieve.

[0014] Further preferably, in step 2, an ethanol solution is used as the extraction solvent, and 70% to 80% ethanol solution is selected for extraction.

[0015] Further preferably, in the step 2, the extraction is carried out by decoction method, the crushed Chinese medicinal materials mixed evenly according to the formula ratio are placed in a stainless steel extraction tank, an appropriate amount of water is added, the amount of water is 2-3 cm above the surface of the medicinal materials, and the medicinal materials are soaked for about 1-2 hours. After the soaking is completed, the heating device is turned on to heat the extraction tank, the water is first boiled quickly over high heat, and then turned to low heat to maintain a slightly boiling state, the temperature is controlled at 90-100°C, and the decoction is continued for 2-3 hours. During the decoction process, the medicinal materials should be stirred in real time. After the decoction is completed, the heating device is turned off, and the extract is allowed to cool naturally to room temperature in the extraction tank, and then filtered using a filtering device, the filtrate is collected, and the filter residue is retained for standby use, the filter residue is subjected to secondary decoction extraction, an appropriate amount of water is added again, and the above-mentioned soaking, heating, decoction, cooling, and filtering steps are repeated, and the filtrate obtained by the secondary decoction is combined with the first filtrate to obtain a total water extract.

[0016] Further preferably, in the step 2, a reflux extraction method is used, the uniformly mixed crushed Chinese medicinal materials are placed in a round-bottom flask, an appropriate amount of ethanol solution with a selected concentration of 70% is added, the amount of ethanol is above the surface of the medicinal materials and is 2-3 cm higher, the round-bottom flask is connected to a reflux condenser, the heating device is turned on, the ethanol solution is kept in a boiling state in the flask, the ethanol vapor rises to the condenser and is cooled and then refluxes into the flask, forming a reflux cycle, and the reflux extraction is continued for 2-3 hours. During the reflux extraction process, the medicinal materials should be stirred in time to ensure that the effective ingredients are fully dissolved. After the reflux extraction is completed, the heating device is turned off, and the extract is allowed to cool naturally to room temperature in the flask, and then filtered using a filtering device, and the filtrate is collected. The filter residue can be subjected to secondary reflux extraction as needed, and the filtrates of the two reflux extractions are combined to obtain a total ethanol extract.

[0017] Further preferably, in the step three, the collected water extract or ethanol extract is placed in a vacuum concentrator for concentration treatment, the vacuum pump of the vacuum concentrator is turned on to reduce the air pressure in the concentrator, and then the heating device is turned on to heat the extract. Under reduced pressure, the boiling point of the extract is reduced, and evaporation and concentration can be carried out at a lower temperature. The temperature is controlled between 50-70°C to avoid destruction of effective ingredients due to high temperature. As the evaporation process proceeds, the volume of the extract gradually decreases. When it is concentrated to a certain extent to form a relatively thick extract, the concentration operation is stopped. The consistency of the extract is preferably such that the extract can slowly flow down when the stirring rod is lifted.

[0018] Further preferably, in the step three, the extract is dried, and the concentrated extract is diluted with an appropriate amount of distilled water or deionized water to a suitable concentration for spraying, and diluted to a solid content of 15% to 20%. The diluted extract is transported to the nozzle of the spray dryer through a peristaltic pump. In the spray dryer, hot air enters from the bottom or side and is heated to 180-200° C. by a heating device. The extract is atomized into tiny droplets at the nozzle, which are fully in contact with the hot air. The water in the droplets is evaporated instantly to form a dry powder, and the dry powder is collected from the bottom collecting port of the spray dryer.

[0019] Further preferably, in the step 4, according to the requirements of granulation and the properties of the drug powder, a suitable auxiliary material is selected, the dried drug powder and the selected auxiliary material are placed in a three-dimensional mixer or a V-type mixer in a certain proportion, and the mixing time and speed are set. The mixing time is 15 to 30 minutes to ensure that the drug powder and the auxiliary material are fully mixed and uniformly obtained to obtain a mixed material, and the mixed material is directly placed in a dry granulator, and the material is squeezed by a pressing roller of the dry granulator to form a thin sheet under pressure, and then the thin sheet is passed through a crushing device of the dry granulator to crush it into granules to obtain dry granules.

[0020] Further preferably, in the step five, the prepared dry granules are placed in a capsule filling machine, and the granules are filled into the capsule shell according to the set filling amount. In the step six, the filled capsules are visually inspected. The capsules should be intact in appearance, without damage, deformation, or cracks, with a smooth surface and uniform color. The appropriate packaging form is selected according to the product's sales channels and market demand.

[0021] The embodiment of the present invention has the following advantages due to the adoption of the above technical solution:

[0022] The present invention optimizes the extraction process, adopts suitable solvents, extraction time, temperature and auxiliary extraction technology, can more fully extract the effective ingredients in the medicinal materials, improve the extraction efficiency and the content of the effective ingredients of the drugs, thereby enhancing the therapeutic effect of the drugs, facilitating production operations and quality control, improving production efficiency and product consistency, and facilitating large-scale production and popularization and application.

[0023] The above summary is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments and features described above, further aspects, embodiments and features of the present invention will be readily apparent by reference to the accompanying drawings and the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0025] Figure 1 The figure is a flow chart of the method of the present invention. DETAILED DESCRIPTION

[0026] In the following, only some exemplary embodiments are briefly described. As those skilled in the art will appreciate, the described embodiments may be modified in various ways without departing from the spirit or scope of the present invention. Therefore, the drawings and descriptions are considered to be exemplary and non-restrictive in nature.

[0027] The embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0028] like Figure 1 As shown, the embodiment of the present invention provides a method for preparing a lung and chest smoothing capsule, comprising the following steps:

[0029] Step 1: Prepare raw materials;

[0030] Step 2: extracting active ingredients;

[0031] Step 3: Concentration and drying;

[0032] Step 4: granulating the materials;

[0033] Step 5: Capsule filling;

[0034] Step 6: Quality inspection and packaging.

[0035] In one embodiment, in step one, the required Chinese medicinal materials are purchased according to a predetermined formula, and the medicinal materials include costus root, tangerine peel, magnolia bark, green tangerine peel, cyperus rotundus, lindera strychnifolia, fructus aurantii, radish seed, perilla stem, areca catechu, platycodon grandiflorum, cardamom and liquorice, and a comprehensive quality inspection is carried out on each batch of purchased Chinese medicinal materials to ensure that the medicinal materials meet the standards.

[0036] In one embodiment, in step one, for the Chinese medicinal materials that need to be processed as specified in the recipe, the traditional processing method is strictly followed, and the inspected and processed Chinese medicinal materials are crushed separately, using a medicinal material crusher, and according to the requirements of the extraction process, the Chinese medicinal materials are crushed into fine powder that can pass through an 80-mesh sieve.

[0037] In one embodiment, in step 2, an ethanol solution is used as the extraction solvent, and 70% to 80% ethanol solution is selected for extraction.

[0038] In one embodiment, in step 2, a decoction method can be used for extraction. The crushed Chinese medicinal materials mixed evenly according to the formula ratio are placed in a stainless steel extraction tank of a suitable size, and an appropriate amount of water is added. The amount of water is generally preferably 2-3 cm above the surface of the medicinal materials. The medicinal materials are soaked for about 1-2 hours to allow the medicinal materials to fully absorb water and expand, which is conducive to the subsequent extraction of effective components. After the soaking is completed, the heating device is turned on to heat the extraction tank. The water is first boiled quickly over high heat, and then turned to low heat to maintain a slightly boiling state. The temperature is controlled at 90-100° C. and the decoction is continued for 2-3 hours. During the decoction process, the medicinal materials should be stirred in real time to allow the medicinal materials to fully contact with water and promote the dissolution of effective components. After the decoction is completed, the heating device is turned off, and the extract is allowed to cool naturally to room temperature in the extraction tank, and then filtered using a filtering device, the filtrate is collected, and the filter residue is reserved for standby use. The filter residue is subjected to secondary decoction extraction, and an appropriate amount of water is added again. The above-mentioned soaking, heating, decoction, cooling, and filtering steps are repeated, and the filtrate obtained by the secondary decoction is combined with the first filtrate to obtain a total water extract;

[0039] The reflux extraction method can also be used. The evenly mixed crushed Chinese medicinal materials are placed in a round-bottom flask, and an appropriate amount of ethanol solution with a selected concentration of 70% is added. The amount of ethanol should be sufficient to cover the surface of the medicinal materials and be 2-3 cm higher. The round-bottom flask is connected to a reflux condenser, and the heating device is turned on to keep the ethanol solution in the flask in a boiling state. The ethanol vapor rises to the condenser and is cooled and then flows back into the flask to form a reflux cycle. The reflux extraction is continued for 2-3 hours. During the reflux extraction process, the medicinal materials should also be stirred in time to ensure that the effective ingredients are fully dissolved. After the reflux extraction is completed, the heating device is turned off, and the extract is allowed to cool naturally to room temperature in the flask, and then filtered using a filtering device. The filtrate is collected, and the filter residue can be subjected to secondary reflux extraction as needed. The filtrates from the two reflux extractions are combined to obtain a total ethanol extract.

[0040] In one embodiment, in step three, the collected water extract or ethanol extract is placed in a vacuum concentrator for concentration treatment, the vacuum pump of the vacuum concentrator is turned on to reduce the air pressure in the concentrator, and then the heating device is turned on to heat the extract. Under reduced pressure, the boiling point of the extract is reduced, and evaporation and concentration can be carried out at a lower temperature. The temperature is controlled between 50-70°C to avoid destruction of effective ingredients due to high temperature. As the evaporation process proceeds, the volume of the extract gradually decreases. When it is concentrated to a certain extent to form a relatively thick extract, the concentration operation is stopped. The consistency of the extract is preferably such that the extract can slowly flow down when the stirring rod is lifted.

[0041] In one embodiment, in step three, the extract is dried, and the concentrated extract is diluted with an appropriate amount of distilled water or deionized water to a suitable concentration for spraying, and the solid content is diluted to 15% to 20%. The diluted extract is transported to the nozzle of the spray dryer through a peristaltic pump. In the spray dryer, hot air enters from the bottom or side, and is heated to 180-200° C. by a heating device. The extract is atomized into tiny droplets at the nozzle, which are fully contacted with the hot air. The water in the droplets is evaporated in an instant to form a dry powder. The dry powder is collected from the bottom collection port of the spray dryer. During the spray drying process, attention should be paid to controlling the inlet temperature, outlet temperature, and spray pressure parameters to ensure that the drying effect is good and the effective ingredients are not destroyed;

[0042] You can also use vacuum drying, spread the concentrated extract evenly on the tray of the vacuum drying oven, with a spreading thickness of no more than 2 cm to ensure uniform drying effect, close the door of the vacuum drying oven, turn on the vacuum pump, pump the air pressure in the box to a certain degree of vacuum state (-0.08MPa to -0.09MPa), turn on the heating device, heat the box, control the temperature at 50-60°C, and dry the extract in a vacuum and low temperature environment. During the drying process, open the door of the box regularly to observe the drying progress of the extract. When the extract becomes dry, brittle and hard, and can be powdered when gently crushed by hand, it means that the drying is completed and the dried powder is taken out from the box.

[0043] In one embodiment, in step 4, according to the requirements of granulation and the properties of the drug powder, a suitable auxiliary material is selected, and the dried drug powder and the selected auxiliary material are placed in a three-dimensional mixer or a V-type mixer in a certain proportion, and the mixing time and speed are set. The mixing time is 15 to 30 minutes to ensure that the drug powder and the auxiliary material are fully mixed and uniformly obtained to obtain a mixed material, and the mixed material is directly placed in a dry granulator, and the material is squeezed by a pressing roller of the dry granulator to form a thin sheet under pressure, and then the thin sheet is passed through a crushing device of the dry granulator to be crushed into granules to obtain dry granules.

[0044] In one embodiment, in step five, the prepared dry granules are placed in a capsule filling machine, and the granules are filled into capsule shells according to a set filling amount.

[0045] In one embodiment, in step six, the filled capsules are visually inspected. The capsules should be intact in appearance, without damage, deformation, or cracks, with a smooth surface and uniform color. A suitable packaging form is selected based on the product's sales channels and market demand.

[0046] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of various changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A method for preparing a lung and chest-soothing capsule, characterized in that: The following steps are involved: Step 1: Prepare raw materials; Step 2: extracting active ingredients; Step 3: Concentration and drying; Step 4: granulating the materials; Step 5: Capsule filling; Step 6: Quality inspection and packaging.

2. The method for preparing a lung and chest-clearing capsule according to claim 1, characterized in that: In the step one, the required Chinese medicinal materials are purchased according to a predetermined formula, and the medicinal materials include costus root, tangerine peel, magnolia bark, green peel, cyperus rotundus, lindera strychnifolia, fructus aurantii, radish seed, perilla stem, areca nut, platycodon grandiflorum, cardamom and liquorice. A comprehensive quality inspection is carried out on each batch of purchased Chinese medicinal materials to ensure that the medicinal materials meet the standards.

3. The method for preparing a lung and chest-clearing capsule according to claim 1, characterized in that: In the step 1, for the Chinese medicinal materials that need to be processed as specified in the formula, the traditional processing method is strictly followed, and the inspected and processed Chinese medicinal materials are crushed separately. A medicinal material crusher is used to crush the Chinese medicinal materials into fine powder that can pass through an 80-mesh sieve according to the requirements of the extraction process.

4. The method for preparing a lung and chest-clearing capsule according to claim 1, characterized in that: In the step 2, an ethanol solution is used as the extraction solvent, and a 70% to 80% ethanol solution is selected for extraction.

5. The method for preparing a lung and chest-clearing capsule according to claim 1, characterized in that: In the step 2, the extraction is performed by decoction method. The crushed Chinese medicinal materials mixed evenly according to the formula ratio are placed in a stainless steel extraction tank, and an appropriate amount of water is added. The amount of water is 2-3 cm above the surface of the medicinal materials. The medicinal materials are soaked for about 1-2 hours. After the soaking is completed, the heating device is turned on to heat the extraction tank. The water is first boiled quickly over high heat, and then turned to low heat to maintain a slightly boiling state. The temperature is controlled at 90-100°C and the decoction is continued for 2-3 hours. During the decoction process, the medicinal materials should be stirred in real time. After the decoction is completed, the heating device is turned off, and the extract is allowed to cool naturally to room temperature in the extraction tank. Then, a filtering device is used for filtering, and the filtrate is collected. The filter residue is reserved for use, and the filter residue is subjected to secondary decoction extraction, and an appropriate amount of water is added again. The above-mentioned soaking, heating, decoction, cooling, and filtering steps are repeated, and the filtrate obtained by the second decoction is combined with the first filtrate to obtain a total water extract.

6. The method for preparing a lung and chest-clearing capsule according to claim 5, characterized in that: In the step 2, a reflux extraction method is used, the mixed and crushed Chinese medicinal materials are placed in a round-bottom flask, and an appropriate amount of ethanol solution with a selected concentration of 70% is added, the amount of ethanol is above the surface of the medicinal materials and 2-3 cm higher, the round-bottom flask is connected to a reflux condenser, and the heating device is turned on to keep the ethanol solution in the flask in a boiling state, and the ethanol vapor rises to the condenser and is cooled and then refluxes into the flask to form a reflux cycle, and the reflux extraction is continued for 2-3 hours. During the reflux extraction process, the medicinal materials should be stirred in time to ensure that the effective ingredients are fully dissolved. After the reflux extraction is completed, the heating device is turned off, and the extract is allowed to cool naturally to room temperature in the flask, and then filtered using a filtering device, and the filtrate is collected. The filter residue can be subjected to secondary reflux extraction as needed, and the filtrates of the two reflux extractions are combined to obtain a total ethanol extract.

7. The method for preparing a lung and chest-clearing capsule according to claim 6, characterized in that: In the step three, the collected water extract or ethanol extract is placed in a vacuum concentrator for concentration treatment, the vacuum pump of the vacuum concentrator is turned on, the air pressure in the concentrator is reduced, and then the heating device is turned on to heat the extract. Under reduced pressure, the boiling point of the extract is reduced, and evaporation and concentration can be performed at a low temperature. The temperature is controlled between 50-70°C to avoid destruction of effective ingredients due to high temperature. As the evaporation process proceeds, the volume of the extract gradually decreases. When it is concentrated to a certain extent to form an extract, the concentration operation is stopped.

8. The method for preparing a lung and chest-clearing capsule according to claim 7, characterized in that: In the step three, the extract is dried, and the concentrated extract is diluted with an appropriate amount of distilled water or deionized water to a suitable concentration for spraying, and the solid content is diluted to 15% to 20%. The diluted extract is transported to the nozzle of the spray dryer through a peristaltic pump. In the spray dryer, hot air enters from the bottom or side and is heated to 180-200° C. by a heating device. The extract is atomized into tiny droplets at the nozzle and fully contacts with the hot air. The water in the droplets is evaporated instantly to form dry powder, and the dry powder is collected from the bottom collection port of the spray dryer.

9. The method for preparing a lung and chest-clearing capsule according to claim 1, characterized in that: In the step 4, according to the requirements of granulation and the properties of the drug powder, a suitable auxiliary material is selected, the dried drug powder and the selected auxiliary material are placed in a three-dimensional mixer or a V-type mixer in a certain proportion, and the mixing time and speed are set. The mixing time is 15 to 30 minutes to ensure that the drug powder and the auxiliary material are fully mixed and uniformly obtained to obtain a mixed material, and the mixed material is directly placed in a dry granulator, and the material is squeezed by a pressing roller of the dry granulator to form a thin sheet under pressure, and then the thin sheet is passed through a crushing device of the dry granulator to be crushed into granules to obtain dry granules.

10. The method for preparing a lung and chest-clearing capsule according to claim 1, characterized in that: In the step five, the prepared dry granules are placed in a capsule filling machine, and the granules are filled into the capsule shell according to the set filling amount. In the step six, the filled capsules are visually inspected. The capsules should be intact in appearance, without damage, deformation, or cracks, with a smooth surface and uniform color. The appropriate packaging form is selected according to the product's sales channels and market demand.

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