Levocarnitine Injection Production Process

Abstract

The present invention belongs to the technical field of pharmaceutical production, and discloses a production process of levocarnitine injection, which includes the following steps: S1. Preparation stage: First, prepare the raw materials levocarnitine hydrochloride and injection water; S2. Liquid preparation stage: Inject the injection water and the raw material levocarnitine into the liquid preparation tank, add HCL during stirring to adjust the pH value of the liquid medicine and make each component fully dissolve and mix evenly to ensure that the liquid preparation meets the requirements; Through the cooperation of structures such as a turntable and leakage holes provided in this device, it is convenient to automatically inject a small amount of hydrochloric acid multiple times. Through transmission, the hydrochloric acid enters the inside of the liquid preparation tank through the leakage holes and fan-shaped grooves in small amounts and multiple times, automatically adjusting the pH value of the liquid medicine. By restricting the amount and frequency of hydrochloric acid entering, the situation where the pH value of the liquid medicine drops sharply due to a large amount of hydrochloric acid being injected at one time is avoided. Each time only part of the hydrochloric acid enters the liquid preparation tank, enabling the pH value of the liquid medicine to gradually decrease in a small amplitude, making it easier to accurately control.

Description

Technical Field

[0001] The present invention belongs to the technical field of pharmaceutical production, specifically the production process of levocarnitine injection. Background Art

[0002] Carnitine plays a key role in the human energy metabolism process. It mainly participates in the β-oxidation of fatty acids and is crucial for the energy supply of tissue cells such as cardiomyocytes and skeletal muscle cells. Clinically, levocarnitine can be used to treat a series of complications caused by secondary carnitine deficiency in long-term hemodialysis patients with chronic renal failure, such as cardiomyopathy, skeletal muscle disease, arrhythmia, hyperlipidemia, hypotension, and muscle spasm during dialysis. With the in-depth understanding of these diseases and the increase in the number of patients, the demand for levocarnitine injection is also increasing day by day, which has promoted the continuous development of its production process.

[0003] Most of the existing levocarnitine injection production equipment adds hydrochloric acid manually, which not only has cumbersome operations but also is prone to errors due to human factors. For example, a large amount of hydrochloric acid is added at one time due to operational errors, resulting in a drastic change in the pH value of the liquid medicine and over-acidification of the liquid medicine. Therefore, a levocarnitine injection production equipment is proposed. Summary of the Invention

[0004] To solve the problems mentioned in the above background art that most hydrochloric acid is added manually, which not only has cumbersome operations but also is prone to errors due to human factors. For example, a large amount of hydrochloric acid is added at one time due to operational errors, resulting in a drastic change in the pH value of the liquid medicine and over-acidification of the liquid medicine, the present invention provides a production process of levocarnitine injection.

[0005] To achieve the above object, the present invention provides the following technical solution: a production process of levocarnitine injection, and the production method is as follows:

[0006] S1. Preparation stage: First, prepare the raw materials levocarnitine, 2mol / L hydrochloric acid, and injection water at 40 - 50°C.

[0007] S2. Liquid preparation stage: Subsequently, in a clean liquid preparation area, inject 52.0 kg of injection water at 40 - 50°C and the raw material levocarnitine into the liquid preparation tank, and stir the raw materials with a stirrer until they are visually completely dissolved. Then measure the pH value. If the measured pH value is not within the qualified range of 6.1 - 6.4, add 2mol / L HCL under stirring to adjust it to 6.1 - 6.4, and make up the injection water to a total volume of 68.3 kg. Then mechanically stir for 10 minutes, and use the stirring equipment to fully dissolve and mix all components evenly. At the same time, detect the various parameters of the solution through a pH meter to ensure that the liquid preparation meets the requirements.

[0008] S3. Encapsulation stage: Subsequently, the liquid medicine is subjected to sterilizing filtration and then filled into pre-cleaned and sterilized packaging containers. The filling volume needs to be strictly controlled during the filling process to ensure that the volume of the injection in each container meets the specified standard with an error within the allowable range. After sealing, labeling, and final product inspection, the production of levocarnitine injection can be completed.

[0009] The production equipment for levocarnitine injection includes a main body mechanism and also includes:

[0010] A feeding mechanism, and the feeding mechanism is arranged above the main body mechanism;

[0011] Among them, the feeding mechanism includes a motor, a gear, a turntable, leakage holes, a partition plate, and a top cover. The bottom of the motor is meshed with the side surface of the turntable through the gear. A number of leakage holes for adding hydrochloric acid are formed on the turntable. A feeding port is arranged on the top cover. A partition plate for separating hydrochloric acid is fixedly connected inside the feeding port. A sector-shaped groove for releasing hydrochloric acid is formed at the bottom of the top cover. A baffle for blocking hydrochloric acid is arranged inside the sector-shaped groove. A sliding groove for limiting the sliding of the baffle is formed inside the top cover.

[0012] Preferably, a water injection pipe is fixedly connected to the top of the top cover. A raw material inlet is arranged on the top of the top cover. The bottom of the motor is fixedly connected to the top of the top cover. The motor is located between the feeding port and the water injection pipe. The gear and the turntable are respectively rotatably connected to the inner wall of the top cover. The axis of the turntable and the center of the feeding port are located on the same vertical axis. The size of the turntable is twice the size of the gear.

[0013] Preferably, a number of the leakage holes are combined with each other to form a sector-shaped area. A number of leakage holes are formed on the partition plate. The a number of leakage holes on the partition plate and the a number of leakage holes on the turntable are respectively aligned. The sliding groove is located below the feeding port. The sliding groove is communicated with the sector-shaped groove. The baffle penetrates through the inner wall of the sliding groove and extends to the side surface of the top cover. A handle is arranged on the baffle.

[0014] Preferably, a stirring mechanism is arranged below the feeding mechanism. The stirring mechanism includes a rotating shaft and a supporting outer shell. Two first bevel gears are fixedly connected to the rotating shaft. A driving bevel gear is meshed with the side surface of one of the first bevel gears. Second bevel gears are meshed with both sides of the other first bevel gear. Stirring rods are fixedly connected to the sides of the two second bevel gears away from each other through connecting rods. A stirring paddle is fixedly connected to the bottom of the rotating shaft. An anti-blocking paddle is fixedly connected to the bottom of the stirring paddle.

[0015] Preferably, the first bevel gear meshing with the transmission bevel gear and the transmission bevel gear are both located inside the support housing. The transmission bevel gear is rotatably connected to the inner wall of the support housing. The rotating shaft penetrates through the support housing and extends below the support housing. The first bevel gear meshing with the second bevel gear is located below the support housing. The stirring paddle is located below the stirring rod. The bottom of the gear is fixedly connected to the top of the first bevel gear through a connecting rod. The top of the support housing is fixedly connected to the bottom of the top cover.

[0016] Preferably, a cleaning mechanism is arranged outside the stirring mechanism. The cleaning mechanism includes a driven bevel gear rotatably connected to the inner wall of the support housing. The bottom of the driven bevel gear is fixedly connected to a rotating housing. Both sides of the rotating housing are fixedly connected with scraping plates through connecting rods. The outer shape of the rotating housing is in the shape of a "cross". The outer shape of the scraping plate is in the shape of a spiral. The scraping plate is provided with an inclined surface and the inclined surface is located below the scraping plate.

[0017] Preferably, both the rotating shaft and the second bevel gear are rotatably connected to the inner wall of the rotating housing. The stirring paddle is located below the rotating housing. The two stirring rods are respectively located on both sides of the rotating housing. The two stirring rods and the two scraping plates are arranged in a staggered manner.

[0018] Preferably, the main body mechanism includes a liquid preparation tank. The bottom of the liquid preparation tank is provided with a discharge port. A filter screen is fixedly connected inside the discharge port. An electric valve is arranged inside the discharge port. A pH detector for detecting the pH value of the liquid medicine inside the liquid preparation tank is arranged on the side of the liquid preparation tank.

[0019] Preferably, the filter screen is located above the electric valve. The top of the liquid preparation tank is snap-connected to the bottom of the top cover. The side of the scraping plate away from the rotating housing is in contact with the inner wall of the liquid preparation tank. The bottom of the stirring paddle is in contact with the bottom of the inner wall of the liquid preparation tank. The anti-blocking paddle is located inside the discharge port. The bottom of the discharge port is in contact with the top of the filter screen.

[0020] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0021] By setting the cooperation of structures such as the turntable and the leakage holes, the present invention facilitates the automatic injection of hydrochloric acid in small amounts and multiple times. Through transmission, hydrochloric acid enters the inside of the liquid preparation tank through the leakage holes and the fan-shaped grooves in small amounts and multiple times, automatically adjusting the pH value of the liquid medicine. By restricting the amount and frequency of hydrochloric acid entering, the situation that the pH value of the liquid medicine drops sharply due to a large amount of hydrochloric acid injected at one time is avoided. Only part of the hydrochloric acid enters the liquid preparation tank each time, enabling the pH value of the liquid medicine to gradually decrease in a small amplitude, being easier to accurately control. And the baffle blocks the fan-shaped groove to prevent hydrochloric acid from continuing to enter the inside of the liquid preparation tank and causing the liquid medicine to be overly acidified.

[0022] Through the cooperation of structures such as the anti-blocking paddle and the rotating housing, the present invention facilitates the rapid stirring of the liquid medicine in the liquid mixing tank. When the motor is started, the stirring paddle and the anti-blocking paddle are driven to stir in the horizontal direction, and the stirring rod stirs in the vertical direction, breaking the concentration gradient in the vertical direction, fully agitating the water for injection at different heights, mixing the upper and lower layers of water, and avoiding stratification. When the rotating housing rotates in the reverse direction, the water for injection is under the combined action of shear forces and stirring forces in different directions, achieving a more uniform and thorough mixing effect, ensuring that all parts of the water for injection can come into full contact and be evenly mixed in the entire three-dimensional space. At the same time, it can also destroy the formation of vortices formed by the rotation of the stirring paddle, change the flow direction of the water flow, continuously redistribute the materials to different flow regions, avoid the mixing dead zones caused by local vortices, and enable the raw material levocarnitine to be quickly and evenly dissolved in the water for injection. At the same time, due to the automatic addition of hydrochloric acid in small amounts and multiple times, under the above-mentioned stirring action, the newly added hydrochloric acid can be quickly and evenly dispersed in the liquid medicine, making the pH value of the entire liquid medicine change evenly, avoiding the situation of too low local pH value, which helps to ensure the chemical stability of levocarnitine in the liquid medicine and prevent the decomposition of levocarnitine or other adverse reactions caused by uneven pH values. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 is a schematic structural diagram of the present invention;

[0024] Figure 2 is a schematic top view structural diagram of the feeding mechanism of the present invention;

[0025] Figure 3 is a schematic cross-sectional structural diagram of the main body mechanism of the present invention;

[0026] Figure 4 is of the present invention Figure 3 the enlarged structural diagram at A in;

[0027] Figure 5 is a schematic diagram of the structural relationship and cooperation between the scraper and the stirring chamber of the present invention;

[0028] Figure 6 is a schematic three-dimensional structural diagram of the cleaning mechanism of the present invention;

[0029] Figure 7 is a schematic diagram of the structural relationship and cooperation between the driving bevel gear and the driven bevel gear of the present invention;

[0030] Figure 8 is a schematic bottom view structural diagram of the stirring mechanism of the present invention.

[0031] In the figure: 1. Feeding mechanism; 101. Motor; 102. Gear; 103. Turntable; 104. Leakage hole; 105. Baffle; 106. Top cover; 107. Feeding port; 108. Partition board; 109. Sector groove; 110. Slide groove; 111. Water injection pipe; 112. Raw material inlet; 2. Stirring mechanism; 201. Rotating shaft; 202. First bevel gear; 203. Driving bevel gear; 204. Support housing; 205. Second bevel gear; 206. Stirring rod; 207. Stirring paddle; 208. Anti-blocking paddle; 3. Cleaning mechanism; 301. Driven bevel gear; 302. Rotating housing; 303. Scraper; 4. Main body mechanism; 401. Liquid preparation tank; 402. Discharge port; 403. Filter screen; 404. Electric valve; 405. PH detector. Specific implementation mode

[0032] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

[0033] The production process of levocarnitine injection is as follows:

[0034] S1. Preparation stage: First, prepare the raw materials levocarnitine, 2mol / L hydrochloric acid, and injection water at 40 - 50°C.

[0035] S2. Liquid preparation stage: Subsequently, in a clean liquid preparation area, inject 52.0 kg of injection water at 40 - 50°C and the raw material levocarnitine into the liquid preparation tank 401. Stir the raw materials until visually completely dissolved by a stirrer, then measure the pH value. If the measured pH value is not within the qualified range of 6.1 - 6.4, add 2mol / L HCL under stirring to adjust to 6.1 - 6.4, and make up the injection water to the full amount of 68.3 kg. Then mechanically stir for 10 minutes, and use the stirring equipment to fully dissolve and mix all components evenly. At the same time, detect the parameters of the solution through the pH meter to ensure that the liquid preparation meets the requirements.

[0036] S3. Encapsulation stage: Subsequently, make the liquid medicine pass through sterilization filtration and then fill it into pre-cleaned and sterilized packaging containers. The filling process needs to strictly control the filling volume to ensure that the volume of the injection liquid in each container meets the specified standard and the error is within the allowable range. After sealing, packaging, labeling, and finished product inspection, the production of levocarnitine injection can be completed.

[0037] As Figures 1 to 8 shown, the present invention provides a levocarnitine injection production device, including the main body mechanism 4, and further including:

[0038] The feeding mechanism 1 is arranged above the main body mechanism 4;

[0039] Among them, the feeding mechanism 1 includes a motor 101, a gear 102, a turntable 103, leakage holes 104, a partition plate 108 and a top cover 106. The bottom of the motor 101 is meshed with the side surface of the turntable 103 through the gear 102. A number of leakage holes 104 for adding hydrochloric acid are provided on the turntable 103. A feeding port 107 is arranged on the top cover 106. A partition plate 108 for separating hydrochloric acid is fixedly connected inside the feeding port 107. A sector-shaped groove 109 for releasing hydrochloric acid is provided at the bottom of the top cover 106. A baffle 105 for blocking hydrochloric acid is arranged inside the sector-shaped groove 109. A sliding groove 110 for limiting the sliding of the baffle 105 is provided inside the top cover 106.

[0040] A water injection pipe 111 is fixedly connected to the top of the top cover 106. A raw material inlet 112 is arranged on the top of the top cover 106. The bottom of the motor 101 is fixedly connected to the top of the top cover 106. The motor 101 is located between the feeding port 107 and the water injection pipe 111. The gear 102 and the turntable 103 are respectively rotatably connected to the inner wall of the top cover 106. The axis of the turntable 103 and the center of the feeding port 107 are located on the same vertical axis. The size of the turntable 103 is twice the size of the gear 102. A number of leakage holes 104 are combined with each other to form a sector area. A number of leakage holes 104 are provided on the partition plate 108. The a number of leakage holes 104 on the partition plate 108 and the a number of leakage holes 104 on the turntable 103 are respectively aligned. The sliding groove 110 is located below the feeding port 107. The sliding groove 110 is communicated with the sector-shaped groove 109. The baffle 105 penetrates through the inner wall of the sliding groove 110 and extends to the side surface of the top cover 106. A handle is arranged on the baffle 105.

[0041] Adopt the above solution: By setting the cooperation of structures such as the turntable 103 and the leakage holes 104, it is convenient to automatically inject hydrochloric acid in small amounts and multiple times. Starting the motor 101 to rotate the gear 102 will drive the turntable 103 to rotate. When the turntable 103 rotates, the leakage holes 104 on the turntable 103 will be misaligned with the leakage holes 104 on the partition plate 108, preventing hydrochloric acid from falling into the internal part of the liquid preparation tank 401 through the leakage holes 104. Also, because the size of the turntable 103 is twice that of the gear 102, after the gear 102 drives the stirring mechanism 2 to stir the liquid medicine for two circles, the leakage holes 104 on the turntable 103 will align with the leakage holes 104 on the partition plate 108 only once, allowing part of the hydrochloric acid to enter the internal part of the liquid preparation tank 401 through the leakage holes 104 and the fan-shaped grooves 109, and quickly mix with the liquid medicine under the stirring of the stirring mechanism 2, automatically adjusting the pH value of the liquid medicine. By restricting the amount and frequency of hydrochloric acid entering, the situation where a large amount of hydrochloric acid is injected at one time causes a sharp drop in the pH value of the liquid medicine is avoided. Each time only part of the hydrochloric acid enters the liquid preparation tank 401, enabling the pH value of the liquid medicine to gradually decrease in a small amplitude, making it easier to accurately control. When the staff observes that the data on the PH detector 405 reaches the qualified range, only need to move the baffle 105 towards the direction close to the motor 101, so that the baffle 105 blocks the fan-shaped groove 109, preventing hydrochloric acid from continuing to enter the internal part of the liquid preparation tank 401 and causing the over-acidification of the liquid medicine.

[0042] As Figure 3 and Figure 8 shown, a stirring mechanism 2 is arranged below the feeding mechanism 1. The stirring mechanism 2 includes a rotating shaft 201 and a support housing 204. Two first bevel gears 202 are fixedly connected to the rotating shaft 201. A transmission bevel gear 203 is meshed with the side of one of the first bevel gears 202. Both sides of the other first bevel gear 202 are meshed with second bevel gears 205. Stirring rods 206 are fixedly connected to the mutually remote sides of the two second bevel gears 205 through connecting rods. A stirring paddle 207 is fixedly connected to the bottom of the rotating shaft 201. An anti-blocking paddle 208 is fixedly connected to the bottom of the stirring paddle 207.

[0043] The first bevel gear 202 meshed with the transmission bevel gear 203 and the transmission bevel gear 203 are both located inside the support housing 204. The transmission bevel gear 203 is rotatably connected to the inner wall of the support housing 204. The rotating shaft 201 penetrates through the support housing 204 and extends to the lower part of the support housing 204. The first bevel gear 202 meshed with the second bevel gear 205 is located below the support housing 204. The stirring paddle 207 is located below the stirring rods 206. The bottom of the gear 102 is fixedly connected to the top of the first bevel gear 202 through a connecting rod. The top of the support housing 204 is fixedly connected to the bottom of the top cover 106.

[0044] A cleaning mechanism 3 is arranged on the outer side of the stirring mechanism 2. The cleaning mechanism 3 includes a driven bevel gear 301 rotatably connected to the inner wall of the support housing 204. A rotating housing 302 is fixedly connected to the bottom of the driven bevel gear 301. Scrapers 303 are fixedly connected to both sides of the rotating housing 302 through connecting rods. The outer shape of the rotating housing 302 is in a "cross" shape, and the outer shape of the scraper 303 is spiral. An inclined surface is arranged on the scraper 303 and is located below the scraper 303. The rotating shaft 201 and the second bevel gear 205 are both rotatably connected to the inner wall of the rotating housing 302. The stirring paddle 207 is located below the rotating housing 302. Two stirring rods 206 are respectively located on both sides of the rotating housing 302. The two stirring rods 206 and the two scrapers 303 are arranged in a staggered manner.

[0045] The main body mechanism 4 includes a liquid preparation tank 401. A discharge port 402 is arranged at the bottom of the liquid preparation tank 401. A filter screen 403 is fixedly connected inside the discharge port 402. An electric valve 404 is arranged inside the discharge port 402. A pH detector 405 for detecting the pH value of the liquid medicine inside the liquid preparation tank 401 is arranged on the side of the liquid preparation tank 401. The filter screen 403 is located above the electric valve 404. The top of the liquid preparation tank 401 is snap-connected to the bottom of the top cover 106. The side of the scraper 303 away from the rotating housing 302 is in contact with the inner wall of the liquid preparation tank 401. The bottom of the stirring paddle 207 is in contact with the bottom of the inner wall of the liquid preparation tank 401. The anti-blocking paddle 208 is arranged inside the discharge port 402. The bottom of the discharge port 402 is in contact with the top of the filter screen 403.

[0046] Adopting the above solution: By setting up the cooperation of structures such as the anti-blocking paddle 208 and the rotating outer shell 302, it is convenient to quickly stir the liquid medicine in the liquid mixing tank 401. Start the motor 101 to rotate the gear 102 and the rotating shaft 201. The rotation of the rotating shaft 201 will drive the stirring paddle 207 and the anti-blocking paddle 208 at its bottom to rotate, stirring the injection water in the horizontal direction. And the rotation of the rotating shaft 201 will drive the second bevel gear 205 to rotate through the first bevel gear 202, causing the stirring rod 206 to rotate on both sides of the rotating outer shell 302, stirring the injection water in the vertical direction, breaking the concentration gradient in the vertical direction, fully agitating the injection water at different heights, mixing the upper and lower layers of water, and avoiding the occurrence of stratification. Moreover, the rotation of the rotating shaft 201 will also drive the transmission bevel gear 203 to rotate through the first bevel gear 202. The rotation of the transmission bevel gear 203 will drive the driven bevel gear 301 to rotate in the direction opposite to the rotation of the first bevel gear 202, so that the "cross"-shaped rotating outer shell 302 rotates in the direction opposite to the rotation of the stirring paddle 207, and drives the stirring rod 206 rotating in the vertical direction to rotate horizontally around the rotating shaft 201. Under the combined action of the shear force and stirring force in different directions of the injection water, a more uniform and thorough mixing effect is achieved, ensuring that all parts of the injection water in the entire three-dimensional space can be fully contacted and mixed evenly. At the same time, it can also destroy the formation of vortices formed by the rotation of the stirring paddle 207, change the flow direction of the water flow, continuously redistribute the material to different flow regions, avoid the mixing dead zone caused by local vortices, and enable the raw material levocarnitine to be quickly and evenly dissolved in the injection water. At the same time, due to the automatic addition of hydrochloric acid in small amounts and multiple times, under the above stirring action, the newly added hydrochloric acid can be quickly and evenly dispersed in the liquid medicine, making the pH value of the entire liquid medicine change evenly, avoiding the situation of too low local pH value, helping to ensure the chemical stability of levocarnitine in the liquid medicine, and preventing the decomposition of levocarnitine or other adverse reactions caused by uneven pH value;

[0047] And setting up the scraper 303 can scrape off the liquid medicine adhering to the inner wall of the liquid mixing tank 401 during feeding, enabling more liquid medicine to participate in the feeding process, improving the product yield, reducing material waste, which is particularly important for the production of drugs with high costs such as levocarnitine injection. At the same time, it avoids the situation of liquid medicine residue contaminating the next batch of liquid medicine, reduces the possibility of residual liquid medicine drying and caking, facilitates the subsequent cleaning and maintenance of the liquid mixing tank, helps to maintain the good performance and hygienic condition of the liquid mixing tank, and ensures the cleanliness and safety of the drug production environment.

[0048] Working principle and usage process of the present invention: First, close the channel of the discharge port 402 through the electric valve 404, and inject 52.0 kg of injection water at 40 - 50 °C into the internal of the liquid preparation tank 401 through the water injection pipe 111. Subsequently, pour the raw material levocarnitine into the internal of the liquid preparation tank 401 through the raw material inlet 112. At the same time, start the motor 101 to make the gear 102 and the rotating shaft 201 rotate. The rotation of the rotating shaft 201 will drive the stirring paddle 207 and the anti-blocking paddle 208 at its bottom to rotate, stir the injection water in the horizontal direction, and the rotation of the rotating shaft 201 will drive the second bevel gear 205 to rotate through the first bevel gear 202, so that the stirring rod 206 rotates on both sides of the rotating housing 302, stir the injection water in the vertical direction, break the concentration gradient in the vertical direction, fully stir the injection water at different heights, and mix the upper and lower layers of water. Moreover, the rotation of the rotating shaft 201 will also drive the transmission bevel gear 203 to rotate through the first bevel gear 202. The rotation of the transmission bevel gear 203 will drive the driven bevel gear 301 to rotate in the direction opposite to the rotation direction of the first bevel gear 202, so that the "cross"-shaped rotating housing 302 rotates in the direction opposite to the rotation direction of the stirring paddle 207, and drives the stirring rod 206 rotating in the vertical direction to rotate horizontally around the rotating shaft 201 as the axis, so that the injection water and the raw material can be mixed evenly;

[0049] Among them, the pH detector 405 will detect the pH value of the liquid medicine in the liquid preparation tank 401 in real time and display it on the screen of the pH detector 405 located outside the liquid preparation tank 401. After the raw material levocarnitine is dissolved, the staff can observe the detection data displayed on the pH detector 405. If the measured pH value is not within the qualified range of 6.1 - 6.4, inject 2 mol / L hydrochloric acid into the internal of the feed inlet 107, and draw the baffle 105 away from the motor 101, so that the part of the baffle 105 located inside the fan-shaped groove 109 is removed, so that the hydrochloric acid in the feed inlet 107 can enter the internal of the liquid preparation tank 401 through the fan-shaped groove 109. The rotation of the gear 102 will drive the turntable 103 to rotate. The rotation of the turntable 103 will misalign the leakage holes 104 on the turntable 103 and the leakage holes 104 on the partition plate 108, so that the hydrochloric acid cannot fall into the internal of the liquid preparation tank 401 through the leakage holes 104. Also, because the size of the turntable 103 is twice the size of the gear 102, when the gear 102 drives the stirring mechanism 2 to stir the liquid medicine for two circles, the leakage holes 104 on the turntable 103 will align with the leakage holes 104 on the partition plate 108 once, so that part of the hydrochloric acid enters the internal of the liquid preparation tank 401 through the leakage holes 104 and the fan-shaped groove 109, and quickly mixes with the liquid medicine under the stirring of the stirring mechanism 2 to adjust the pH value of the liquid medicine. When the staff observes that the data on the pH detector 405 reaches the qualified range, only need to move the baffle 105 towards the direction close to the motor 101 to block the fan-shaped groove 109 with the baffle 105;

[0050] Finally, open the electric valve 404 so that the liquid medicine in the liquid dispensing tank 401 can pass through the preliminary filtration of the filter screen 403 and move to the sterilizing filter through the discharge port 402.

[0051] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.

[0052] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A L-carnitine injection production device, comprising a main body (4), characterized in that: Also includes: A feeding mechanism (1), wherein the feeding mechanism (1) is arranged above the main body mechanism (4); A stirring mechanism (2) is provided below the feeding mechanism (1), a cleaning mechanism (3) is provided outside the stirring mechanism (2), the main body mechanism (4) comprises a liquid preparation tank (401), and a pH detector (405) for detecting the pH value of the liquid in the liquid preparation tank (401) is provided on the side of the liquid preparation tank (401); The feeding mechanism (1) comprises a motor (101), a gear (102), a rotating disk (103), a leak hole (104), a partition (108) and a top cover (106); the bottom of the motor (101) is meshed with the side of the rotating disk (103) through the gear (102); the rotating disk (103) is provided with a plurality of leak holes (104) for adding hydrochloric acid; the top cover (106) is provided with a feeding port (107); the inside of the feeding port (107) is fixedly connected with a partition (108) for separating hydrochloric acid, a fan-shaped groove (109) for releasing hydrochloric acid is provided at the bottom of the top cover (106), a baffle (105) for blocking hydrochloric acid is provided inside the fan-shaped groove (109), and a slide groove (110) for limiting the sliding of the baffle (105) is provided inside the top cover (106); a water injection pipe (111) is fixedly connected to the top of the top cover (106), and a raw material inlet (112) is provided at the top of the top cover (106); The bottom of the motor (101) is fixedly connected to the top of the top cover (106); the motor (101) is located between the feed port (107) and the water injection pipe (111); the gear (102) and the turntable (103) are rotatably connected to the inner wall of the top cover (106), the axis of the turntable (103) and the center of the feed port (107) are located on the same vertical axis, and the size of the turntable (103) is twice the size of the gear (102); a plurality of the leakage holes (104) are combined with each other. A fan-shaped area is formed, the partition (108) is provided with a plurality of leakage holes (104), the plurality of leakage holes (104) on the partition (108) and the plurality of leakage holes (104) on the turntable (103) are aligned respectively, the chute (110) is located below the feed port (107), the chute (110) is communicated with the fan-shaped chute (109), the baffle (105) penetrates the inner wall of the chute (110) and extends to the side of the top cover (106), and the baffle (105) is provided with a handle.

2. The L-carnitine injection production equipment according to claim 1, characterized in that: The stirring mechanism (2) comprises a rotating shaft (201) and a supporting shell (204); two first bevel gears (202) are fixedly connected to the rotating shaft (201); a transmission bevel gear (203) is meshed on the side of one of the first bevel gears (202); second bevel gears (205) are meshed on both sides of the other first bevel gear (202); a stirring rod (206) is fixedly connected to the sides of the two second bevel gears (205) away from each other via a connecting rod; a stirring paddle (207) is fixedly connected to the bottom of the rotating shaft (201); and an anti-blocking paddle (208) is fixedly connected to the bottom of the stirring paddle (207).

3. The L-carnitine injection production equipment according to claim 2, characterized in that: The first bevel gear (202) meshing with the transmission bevel gear (203) and the transmission bevel gear (203) are both located inside the support shell (204); the transmission bevel gear (203) is rotatably connected to the inner wall of the support shell (204); the rotating shaft (201) penetrates the support shell (204) and extends to the bottom of the support shell (204); the first bevel gear (202) meshing with the second bevel gear (205) is located below the support shell (204); the stirring paddle (207) is located below the stirring rod (206); the bottom of the gear (102) is fixedly connected to the top of the first bevel gear (202) via a connecting rod; and the top of the support shell (204) is fixedly connected to the bottom of the top cover (106).

4. The L-carnitine injection production equipment according to claim 2, characterized in that: The cleaning mechanism (3) comprises a driven bevel gear (301) rotatably connected to the inner wall of the supporting shell (204); the bottom of the driven bevel gear (301) is fixedly connected to a rotating shell (302); both sides of the rotating shell (302) are fixedly connected to a scraper (303) via a connecting rod; the rotating shell (302) has a "cross" shape; the scraper (303) has a spiral shape; and an inclined surface is provided on the scraper (303) and is located below the scraper (303).

5. The L-carnitine injection production equipment according to claim 4, characterized in that: The rotating shaft (201) and the second bevel gear (205) are both rotatably connected to the inner wall of the rotating shell (302); the stirring paddle (207) is located below the rotating shell (302); the two stirring rods (206) are respectively located on both sides of the rotating shell (302); and the two stirring rods (206) and the two scrapers (303) are staggered.

6. The L-carnitine injection production equipment according to claim 4, characterized in that: The main body (4) comprises a liquid preparation tank (401), a discharge port (402) is arranged at the bottom of the liquid preparation tank (401), a filter screen (403) is fixedly connected to the inside of the discharge port (402), and an electric valve (404) is arranged inside the discharge port (402).

7. The L-carnitine injection production equipment according to claim 6, characterized in that: The filter screen (403) is located above the electric valve (404), the top of the liquid preparation tank (401) is clamped with the bottom of the top cover (106), the side of the scraper (303) away from the rotating shell (302) is in contact with the inner wall of the liquid preparation tank (401), the bottom of the stirring paddle (207) is in contact with the bottom of the inner wall of the liquid preparation tank (401), the anti-blocking paddle (208) is located inside the discharge port (402), and the bottom of the discharge port (402) is in contact with the top of the filter screen (403).

8. The L-carnitine injection production equipment according to any one of claims 1 to 7, characterized in that: The feeding mechanism (1) is applied to the liquid preparation stage of the L-carnitine injection production process.

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