Electrode lead, stimulator system and computer readable storage medium

Abstract

The invention provides an electrode wire, a stimulator system and a computer readable storage medium, the electrode wire comprises a catheter, at least one electrode contact and a signal processing chip, each electrode contact is attached to the outer wall of the catheter, and each electrode contact is used for collecting a bio-electricity signal of a patient, and / or collecting the bio-electricity signal of the patient. Delivering electrical stimulation to the in vivo tissue of the patient according to the stimulation pulse signal; and the signal processing chip is arranged in the conduit. According to the invention, the signal processing chip is integrated in the electrode wire, so that the interference of external interference and stimulation pulse signals on bio-electricity signals is reduced.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to electrode leads, stimulator systems, and computer-readable storage media. Background Art

[0002] The electrode contacts are the carriers of electrical stimulation therapy and bioelectric signal collection. The electrode contacts and the pulse generator are electrically connected through the corresponding cables (electrode wires and extension wires). Generally speaking, the amplitude of bioelectric signals is in the μV range, while the amplitude of stimulation pulse signals is in the V range, which is 6 orders of magnitude different. Even if a shielding layer is added inside the cable, the bioelectric signal (analog signal) is easily interfered by the external environment and the stimulation pulse signal inside the cable, which brings troubles to the analysis of bioelectric signals and the subsequent closed-loop control.

[0003] Based on this, the present application provides electrode wires, stimulator systems, and computer-readable storage media to improve related technologies. Summary of the invention

[0004] The purpose of this application is to provide an electrode wire, a stimulator system and a computer-readable storage medium, which integrates a signal processing chip inside the electrode wire to reduce the interference of external interference and stimulation pulse signals on bioelectric signals.

[0005] The purpose of this application is achieved by the following technical solutions:

[0006] In a first aspect, the present application provides an electrode lead, the electrode lead comprising a catheter, at least one electrode contact, and a signal processing chip:

[0007] Each electrode contact is attached to the outer wall of the catheter, and each electrode contact is used to collect bioelectric signals of the patient, and / or deliver electrical stimulation to the patient's body tissue according to the stimulation pulse signal;

[0008] The signal processing chip is arranged inside the catheter.

[0009] In some optional embodiments, the signal processing chip integrates a signal analysis circuit and a signal acquisition circuit, wherein the signal analysis circuit is used to analyze the stimulation control instructions sent by the pulse generator and convert them into the stimulation pulse signal, and the signal acquisition circuit is used to convert the bioelectric signals collected by the electrode contacts into digital signals to be tested and output them.

[0010] The beneficial effect of this technical solution is that by integrating the signal processing chip inside the electrode wire, the interference of external interference and stimulation pulse signals on the bioelectric signal is reduced. The traditional practice is to integrate the signal analysis circuit and the signal acquisition circuit inside the pulse generator, and transmit the bioelectric signal (analog signal) and the stimulation pulse signal through the cable at the same time. The present application transplants the signal analysis circuit and the signal acquisition circuit inside the original pulse generator into the electrode wire in the form of ASIC, and uses the signal processing chip to convert the bioelectric signal (analog signal) originally transmitted in the cable into a digital signal. Compared with the analog signal, the digital signal has a stronger anti-interference ability, and by placing the signal processing chip inside the wire, the bioelectric signal can be processed at a position closer to the electrode contact, thereby reducing the impact of external interference on the bioelectric signal, and further improving the signal's anti-interference ability. In summary, the electrode wire provided by this application is helpful to improve the effect and quality of bioelectric signal acquisition and reduce the problems of external interference and signal cross interference.

[0011] In some optional embodiments, a plurality of groups of electrode contacts are provided along the length direction of the catheter, and each group of electrode contacts is evenly distributed along the circumference of the catheter.

[0012] In some optional embodiments, for each group of electrode contacts, while any one electrode contact delivers electrical stimulation to the patient's internal tissue according to the stimulation pulse signal, it uses part or all of the other electrode contacts in the same group to collect the patient's bioelectric signals.

[0013] The beneficial effects of this technical solution are: on the one hand, multiple stimulation contacts can be divided into multiple groups along the length direction of the catheter. By setting up segmented stimulation contacts, each group of stimulation contacts can achieve separate directional electrical stimulation, so that the electrical stimulation generated can be targeted at specific parts / directions, thereby reducing excessive treatment; on the one hand, multi-channel bioelectric signal acquisition and electrical stimulation can be performed, and combinations of different electrode contacts can be used for electrical stimulation and signal acquisition respectively, which helps to isolate electrical stimulation signals and bioelectric signals and reduce cross-interference. By evenly distributing multiple electrode contacts around the circumference of the catheter, better spatial resolution can be obtained, which helps to locate and analyze the signal source of the bioelectric signal; on the other hand, while one electrode contact delivers electrical stimulation, other electrode contacts are used to collect bioelectric signals, achieving the effect of stimulating and collecting at the same time, so that the bioelectric signals collected can better reflect the patient's actual EEG condition during electrical stimulation treatment.

[0014] In some optional embodiments, the electrode wire is provided with 2 to 8 groups of electrode contacts.

[0015] In some optional embodiments, the electrode wire is provided with 4 groups of electrode contacts.

[0016] In some optional embodiments, each group of electrode contacts includes 1 to 9 electrode contacts.

[0017] In some optional embodiments, each group of electrode contacts includes 3 electrode contacts.

[0018] The beneficial effect of this technical solution is that each set of electrode contacts provides 3 electrodes, so there are a total of 12 electrode contacts available, which enables the electrode wire to collect bioelectric signals from more channels at the same time, thereby providing richer and more comprehensive signal information. The 3 electrode contacts in each set of electrode contacts can collect signals at different angles and depths, which is very helpful for locating signal sources, analyzing signal changes, and studying the electrical activity characteristics of tissues in the body. By combining within each set of electrode contacts, a variety of stimulation modes can be achieved, such as selectively stimulating different areas, adjusting the stimulation intensity, etc., which is very valuable for some specific electrical stimulation therapy applications.

[0019] In some optional embodiments, the catheter is made of a rubber tube, the signal processing chip includes at least one bare chip, the signal processing chip is electrically connected to each electrode contact via a metal wire, and each bare chip is electrically connected to each other via a metal wire.

[0020] The beneficial effect of this technical solution is that the rubber tube as a catheter material has a certain flexibility and can adapt to the shapes of different organs and tissues. This flexibility helps to improve the patient's comfort and implant experience. Using metal wires to connect the signal processing chip and the electrode contacts can reduce the loss and interference of signal transmission. The metal wires can effectively transmit bioelectric signals and stimulation pulse signals, which helps to maintain the integrity of the signal. Each electrode contact is electrically connected to the signal processing chip, and the bare chips are also connected to each other through metal wires. The modular design of this chip makes subsequent maintenance, upgrades and replacements more convenient.

[0021] In some optional embodiments, the signal processing chip includes 1 to 10 bare chips.

[0022] In some optional embodiments, the signal processing chip includes three bare chips.

[0023] In some optional embodiments, three bare chips form a triangular prism structure;

[0024] In some optional embodiments, adhesive is filled between the signal processing chip and the inner wall of the catheter to fix the signal processing chip inside the catheter.

[0025] The beneficial effect of this technical solution is that the triangular prism structure can effectively utilize the internal space of the catheter, making the signal processing chip more stable in a limited space. This compact structure helps to simplify the layout of the electrode wires. Using an adhesive to fix the signal processing chip inside the catheter can prevent the signal processing chip from loosening or shifting during use, thereby improving the stability and reliability of the electrode wires. On the one hand, fixing the signal processing chip directly inside the catheter can optimize the signal transmission path, reduce signal transmission loss and interference, and thus improve signal quality. On the other hand, the signal processing chip is completely encapsulated inside the catheter, which can reduce the impact of the external environment on the signal processing chip and further improve the stability and accuracy of the signal.

[0026] In some optional embodiments, the signal acquisition circuit includes an amplification module, a bandpass filtering module and an analog-to-digital conversion module, and the process of converting the bioelectric signal into a digital signal to be measured includes:

[0027] The amplification module is used to amplify the bioelectric signal to obtain a first intermediate signal;

[0028] The bandpass filtering module is used to perform bandpass filtering on the first intermediate signal to obtain a second intermediate signal;

[0029] The analog-to-digital conversion module is used to perform analog-to-digital conversion processing on the second intermediate signal to obtain the digital signal to be tested.

[0030] The beneficial effect of this technical solution is that the signal acquisition circuit is designed to include an amplification module, a bandpass filtering module and an analog-to-digital conversion module, so that the process of converting the bioelectric signal into a digital signal to be measured covers the steps of amplification, filtering and analog-to-digital conversion. Specifically, the amplification module can enhance the amplitude of the bioelectric signal, making it easier to process and analyze, the bandpass filtering module can filter out interference and noise from the outside world, making the signal more reliable, and filtering can also highlight the signal within a specific frequency range, which is helpful for analyzing specific physiological phenomena. The analog-to-digital conversion module converts the continuous analog signal into a digital signal, so that the signal can be processed, stored and analyzed on a digital device. This digital signal is easier to process and can be further analyzed in a computer system. In summary, converting the bioelectric signal into a digital signal to be measured can reduce the error of the analog signal during transmission and processing, thereby improving the accuracy and reliability of the signal.

[0031] In some optional embodiments, the patient's in vivo tissue includes the subthalamic nucleus.

[0032] In some optional embodiments, the bioelectric signal includes a local field potential signal.

[0033] The beneficial effect of this technical solution is that the subthalamic nucleus is an important area in the brain, involved in a variety of neural functions, such as motor control, emotional regulation, etc. By collecting local field potential signals, detailed information about the activity of the subthalamic nucleus can be obtained, which is helpful for studying its function and regulatory mechanism. In clinical applications, the treatment of specific patients (such as Parkinson's patients) may need to be adjusted according to their subthalamic nucleus activity. The collection of local field potential signals can provide important physiological information for individualized treatment. Through stimulation pulse signals, targeted electrical stimulation can be delivered to the subthalamic nucleus, which is of great help in the neuroregulatory treatment of Parkinson's patients.

[0034] In a second aspect, the present application provides a stimulator system, comprising: a pulse generator and any one of the electrode wires described above, wherein the pulse generator is electrically connected to a signal processing chip in the electrode wire.

[0035] In some optional embodiments, the pulse generator includes a memory and at least one processor, the memory stores a computer program, and the at least one processor is configured to implement the following steps when executing the computer program:

[0036] Receiving the digital signal to be tested output by the signal processing chip;

[0037] According to the digital signal to be tested, a corresponding stimulation control instruction is generated, and the stimulation control instruction is output to the signal processing chip.

[0038] In some optional embodiments, the at least one processor is configured to further implement the following steps when executing the computer program:

[0039] Obtaining disease information of the patient;

[0040] According to the disease information and the digital signal to be tested, setting a first duration and a second duration corresponding to a signal acquisition period;

[0041] Wherein, during the first time period, at least one electrode contact is used to deliver electrical stimulation to the patient's body tissue while collecting the patient's bioelectrical signal;

[0042] During the second time period, bioelectric signals of the patient are collected using at least one electrode contact without delivering electrical stimulation.

[0043] The beneficial effect of this technical solution is that: according to the patient's disease information, combined with the digital signal to be tested, the first duration and the second duration of the signal acquisition cycle are set. In the first duration, the stimulator system collects bioelectric signals while delivering electrical stimulation through electrode contacts (stimulating while collecting), and in the second duration, the stimulator system only collects bioelectric signals without electrical stimulation (collecting without stimulation). In this way, the bioelectric signals of the patient when receiving electrical stimulation can be obtained, and the bioelectric signals of the patient when not receiving electrical stimulation can be obtained. The two bioelectric signals are analyzed and compared comprehensively to provide an accurate basis for closed-loop stimulation.

[0044] In a third aspect, the present application provides a computer-readable storage medium storing a computer program, which implements the functions of any of the above-mentioned stimulator systems when executed by at least one processor.

[0045] In a fourth aspect, the present application further provides a computer program product, the computer program product comprising a computer program, and the computer program implements the functions of any of the above-mentioned stimulator systems when executed by at least one processor. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] The present application is further described below in conjunction with the accompanying drawings and implementation methods.

[0047] Figure 1 It is a schematic diagram of the structure of an electrode wire provided in an embodiment of the present application.

[0048] Figure 2 It is a schematic diagram of the structure of another electrode wire provided in an embodiment of the present application.

[0049] Figure 3 It is a schematic diagram of the principle of signal transmission of a stimulator system provided in an embodiment of the present application.

[0050] Figure 4 It is a structural block diagram of a stimulator system provided in an embodiment of the present application.

[0051] Figure 5 It is a structural diagram of a program product provided in an embodiment of the present application. DETAILED DESCRIPTION

[0052] The technical solution in the present application will be described below in conjunction with the drawings and specific implementation methods of the specification of the present application. It should be noted that, under the premise of no conflict, the various implementation methods or technical features described below can be arbitrarily combined to form a new implementation method.

[0053] In the embodiments of the present application, "at least one" refers to one or more, and "plurality" refers to two or more. "And / or" describes the association relationship of associated objects, indicating that three relationships may exist. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone, where A and B can be singular or plural. The character " / " generally indicates that the associated objects before and after are in an "or" relationship. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single or plural items. For example, at least one of a, b or c can represent: a, b, c, a and b, a and c, b and c, a and b and c, where a, b and c can be single or multiple. It is worth noting that "at least one" can also be interpreted as "one or more items".

[0054] It should also be noted that in the embodiments of the present application, words such as "exemplary" or "for example" are used to indicate examples, illustrations or descriptions. Any implementation or design scheme described as "exemplary" or "for example" in the embodiments of the present application should not be interpreted as being more preferred or more advantageous than other implementations or designs. Specifically, the use of words such as "exemplary" or "for example" is intended to present related concepts in a specific way.

[0055] Below, one of the application fields of the present application (i.e., implantable neural stimulator) is briefly described.

[0056] Implantable medical systems include implantable neural stimulation systems, implantable cardiac stimulation systems (also known as pacemakers), implantable drug delivery systems (IDDS), and lead switching systems. Examples of implantable neural stimulation systems include deep brain stimulation (DBS), implantable cortical nerve stimulation (CNS), implantable spinal cord stimulation (SCS), implantable sacral nerve stimulation (SNS), and implantable vagus nerve stimulation (VNS).

[0057] The implantable neural electrical stimulation system includes a stimulator implanted in the patient's body (i.e., an implantable neural stimulator, a neural stimulation device) and a programmable device disposed outside the patient's body. In other words, the stimulator is an implant, or the implant includes the stimulator. The relevant neural regulation technology mainly implants electrodes (electrodes, for example, in the form of electrode wires) in specific parts of the tissue of the organism (i.e., target points) through stereotactic surgery, and emits discharge pulses to the target points through the electrodes to regulate the electrical activities and functions of the corresponding neural structures and networks, thereby improving symptoms and relieving pain. Among them, the stimulator may include an IPG, an extension wire and an electrode wire. The IPG (implantable pulse generator) is disposed in the patient's body, responds to the programmable instructions sent by the programmable device, and relies on sealed batteries and circuits to provide controllable electrical stimulation energy to the tissues in the body. The IPG delivers one or more controllable specific electrical stimulations to specific areas of the tissues in the body through the extension wire and the electrode wire. The extension wire is used in conjunction with the IPG as a transmission medium for the electrical stimulation signal, and transmits the electrical stimulation signal generated by the IPG to the electrode wire. The electrode wire delivers electrical stimulation to a specific area of ​​the tissue in the body through a plurality of electrode contacts. The stimulator is provided with one or more electrode wires on one side or both sides, and a plurality of electrode contacts are provided on the electrode wire, and the electrode contacts can be arranged uniformly or non-uniformly on the circumference of the electrode wire. As an example, the electrode contacts can be arranged in an array of 4 rows and 3 columns (a total of 12 electrode contacts) on the circumference of the electrode wire. The electrode contacts can include stimulation electrode contacts and / or collection electrode contacts. The electrode contacts can be in the shape of sheets, rings, dots, etc., for example.

[0058] In other embodiments, the stimulator only includes a pulse generator and an electrode wire, wherein the pulse generator is embedded in the patient's skull and the electrode wire is implanted in the patient's skull, and the pulse generator is directly connected to the electrode wire without extending the wire.

[0059] As an example, a deep brain stimulation system (DBS) includes an implantable pulse generator (IPG), an extension wire and an electrode wire, and the IPG is connected to the electrode wire through the extension wire. The IPG is implanted in the patient's body, for example, in the patient's chest or other body parts.

[0060] As another example, DBS includes an IPG and an electrode lead, and the IPG is directly connected to the electrode lead. The IPG is implanted in the patient's head, for example, a groove is made in the patient's skull, and then the IPG is installed in the groove of the skull. In this case, the IPG may not protrude from the outer surface of the skull, or may partially protrude from the outer surface of the skull.

[0061] In some embodiments, the stimulated body tissue may be the patient's brain tissue, and the stimulated site may be a specific site of the brain tissue. When the patient's disease type is different, the stimulated site is generally different, and the number of stimulation contacts (single source or multiple sources) used, the use of one or more (single channel or multiple channels) specific electrical stimulation signals, and the stimulation parameter data are also different. The embodiments of the present application do not limit the applicable disease types, which may be deep brain stimulation (DBS), spinal cord stimulation (SCS), pelvic stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation. The disease type is applicable. Among them, the types of diseases that DBS can be used to treat or manage include, but are not limited to: spastic disorders (e.g., epilepsy), pain, migraine, psychiatric disorders (e.g., major depressive disorder (MDD)), bipolar disorder, anxiety disorders, post-traumatic stress disorder, hypotension, obsessive-compulsive disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental state disorders, movement disorders (e.g., essential tremor or Parkinson's disease), Huntington's disease, Alzheimer's disease, drug addiction, autism or other neurological or psychiatric diseases and injuries.

[0062] In the embodiment of the present application, when the programmable device and the stimulator establish a programmable connection, the programmable device can be used to adjust the stimulation parameters of the stimulator (or the stimulation parameters of the pulse generator, different stimulation parameters correspond to different electrical stimulation signals), or the stimulator can sense the patient's electrophysiological activities to collect bioelectric signals, and the collected bioelectric signals can be used to continue to adjust the stimulation parameters of the stimulator.

[0063] The stimulation parameters of the electrical stimulation signal may include frequency (for example, the number of electrical stimulation pulse signals within a unit time of 1s, in Hz), pulse width (duration of each pulse, in μs), and amplitude (generally expressed in voltage, that is, the intensity of each pulse, in V), timing (for example, continuous or triggered), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode and cyclic stimulation mode), doctor-controlled upper and lower limits (range adjustable by the doctor) and patient-controlled upper and lower limits (range adjustable by the patient). Any one or more of the above. In specific applications, the stimulation parameters of the stimulator can be adjusted in current mode or voltage mode.

[0064] The programmable device can be a doctor's programmer (i.e., a programmer used by a doctor) or a patient programmer (i.e., a programmer used by a patient). The doctor's programmer can be, for example, a tablet computer, a laptop computer, a desktop computer, a mobile phone, or other intelligent terminal device equipped with programmable software. The patient programmer can be, for example, a tablet computer, a laptop computer, a desktop computer, a mobile phone, or other intelligent terminal device equipped with programmable software. The patient programmer can also be other electronic devices with programmable functions (e.g., a charger with programmable functions, a data acquisition device).

[0065] This application does not restrict the data interaction between the doctor programmer and the stimulator. When the doctor performs remote programming, the doctor programmer can interact with the stimulator through the server and the patient programmer. When the doctor performs offline programming with the patient face to face, the doctor programmer can interact with the stimulator through the patient programmer, and the doctor programmer can also interact with the stimulator directly.

[0066] The patient programmer may include a host communicating with the server and a sub-machine communicating with the stimulator, and the host and the sub-machine may be connected in a communicative manner. Among them, the doctor programmer may exchange data with the server through the 3G / 4G / 5G network, the server may exchange data with the host through the 3G / 4G / 5G network, the host may exchange data with the sub-machine through the Bluetooth protocol / WIFI protocol / USB protocol, the sub-machine may exchange data with the stimulator through the 401MHz-406MHz working frequency band / 2.4GHz-2.48GHz working frequency band, and the doctor programmer may directly exchange data with the stimulator through the 401MHz-406MHz working frequency band / 2.4GHz-2.48GHz working frequency band.

[0067] In order to achieve real-time closed-loop stimulation, the electrode contacts, in addition to providing electrical stimulation, also need to collect bioelectric signals. In other words, the electrode contacts are the carriers of electrical stimulation therapy and bioelectric signal collection, and the electrode contacts and the pulse generator are electrically connected through corresponding cables (electrode wires and extension wires). Generally speaking, the amplitude of bioelectric signals is on the order of μV, while the amplitude of stimulation pulse signals is on the order of V, which differs by 6 orders of magnitude. Even if a shielding layer is added inside the cable, the bioelectric signal (analog signal) is easily interfered by the external environment and the stimulation pulse signal inside the cable, which causes troubles in the analysis of bioelectric signals and subsequent closed-loop control.

[0068] Based on this, the present application provides electrode wires, stimulator systems, and computer-readable storage media to improve related technologies.

[0069] Electrode Lead Embodiment

[0070] See also Figure 1 and Figure 2 , Figure 1is a schematic diagram of the structure of an electrode conductor provided in an embodiment of the present application, Figure 2 It is a schematic diagram of the structure of another electrode wire provided in an embodiment of the present application.

[0071] The electrode lead comprises a catheter, at least one electrode contact and a signal processing chip:

[0072] Each electrode contact is attached to the outer wall of the catheter, and each electrode contact is used to collect bioelectric signals of the patient, and / or deliver electrical stimulation to the patient's body tissue according to the stimulation pulse signal;

[0073] The signal processing chip is arranged inside the catheter.

[0074] In some embodiments, the signal processing chip integrates a signal analysis circuit and a signal acquisition circuit, wherein the signal analysis circuit is used to analyze the stimulation control instructions sent by the pulse generator and convert them into the stimulation pulse signal, and the signal acquisition circuit is used to convert the bioelectric signals collected by the electrode contacts into digital signals to be tested and output them.

[0075] The embodiments of the present application do not limit the types of bioelectric signals, and the bioelectric signals may include neuronal signals and / or local field potential signals.

[0076] Neuronal signals are electrical signals generated by neuronal cells and are used to transmit information between neurons. Neuronal signals usually exist in the form of pulses, which are called action potentials. The collection and analysis of neuronal signals can provide information about neuronal activity, thereby helping to understand the functions and abnormalities of the nervous system. Local field potential signals (Local Field Potential, also known as LFP signals) refer to the changes in electric potential generated by the electrical activity of surrounding neurons. The collection of local field potential signals can provide information about neural network activity and the behavior of neuronal populations. By analyzing local field potential signals, we can understand the synchronization, regulatory mechanisms, and electrical activities associated with specific functions of neuronal populations. By collecting and analyzing neuronal signals and / or local field potential signals, we can obtain important information about the function and disease state of the nervous system, which is helpful for the diagnosis and treatment of neurological diseases and provides personalized closed-loop deep brain stimulation therapy.

[0077] The present application does not limit the types of patients to which the electrode wires are applicable, such as Parkinson's patients, obsessive-compulsive disorder patients, etc. The following uses Parkinson's disease as an example for ease of understanding. Parkinson's disease is a neurodegenerative disease whose main symptoms are movement disorders, such as tremor, bradykinesia and muscle rigidity; the bioelectric signal used to obtain is, for example, a local field potential signal (Local Field Potential, also known as LFP signal). Parkinson's disease is usually manifested as the power spectral density of the LFP signal β band (13-35Hz) being higher or lower than a preset range, that is, the power spectral density is abnormal. In other words, judging whether the power spectral density is abnormal can be used as an important basis for closed-loop feedback for Parkinson's patients, and can be used to adjust the parameters of the patient's electrical stimulation to improve the symptoms of Parkinson's patients.

[0078] As an example, the electrode wire includes a catheter, at least one electrode contact and a signal processing chip. Among them, the catheter is a soft and insulating tubular structure for accommodating electrode contacts and signal processing chips, and it can be made of elastic materials such as rubber to adapt to the curves and shapes of biological tissues. Several electrode contacts are attached to the outer wall of the catheter. For example, 4*3 electrode contacts are provided. These electrode contacts are attached to the outer wall of the catheter and are used to collect bioelectric signals or deliver electrical stimulation according to stimulation control instructions. Each electrode contact can contact different brain regions or neurons. The signal processing chip is located inside the catheter and is used to process the collected signals and perform stimulation control. The signal processing chip integrates a signal analysis circuit and a signal acquisition circuit. Among them, the signal analysis circuit is used to parse the stimulation control instructions from the pulse generator. For example, when the stimulator needs to perform electrical stimulation at a specific time, position and a certain intensity, the signal analysis circuit can interpret these instructions as parameters of the stimulation pulse signal. The signal acquisition circuit is used to convert the bioelectric signals from the electrode contacts into digital signals. Assuming that the electrode contacts record the electrical activity of the brain area, the signal acquisition circuit will amplify and filter these weak bioelectric signals and convert them into digital signals to be tested for further processing and analysis.

[0079] Therefore, by integrating the signal processing chip inside the electrode wire, the interference of external interference and stimulation pulse signal on the bioelectric signal is reduced. The traditional approach is to integrate the signal analysis circuit and the signal acquisition circuit inside the pulse generator, and transmit the bioelectric signal (analog signal) and the stimulation pulse signal through the cable at the same time. The present application transplants the signal analysis circuit and the signal acquisition circuit inside the original pulse generator into the electrode wire in the form of ASIC, and uses the signal processing chip to convert the bioelectric signal (analog signal) originally transmitted in the cable into a digital signal. Compared with the analog signal, the digital signal has a stronger anti-interference ability, and by placing the signal processing chip inside the wire, the bioelectric signal can be processed at a position closer to the electrode contact, thereby reducing the impact of external interference on the bioelectric signal, and further improving the signal's anti-interference ability. In summary, the electrode wire provided by the present application is helpful to improve the effect and quality of bioelectric signal acquisition, and reduce the problems of external interference and signal cross interference.

[0080] The electrode wire provided in the present application can replace the analog small signal originally transmitted in the cable with a digital signal, thereby alleviating the influence of the cable transmission on the external environment (such as electrocardiogram signals, electrooculogram signals, electromyography signals, strong external magnetic fields, strong external electric fields, etc.) and internal strong electrical stimulation signals, and reducing the influence of LFP signal analysis deviation on IPG closed-loop control.

[0081] In some embodiments, the signal acquisition circuit includes an amplification module, a bandpass filtering module, and an analog-to-digital conversion module;

[0082] The amplification module is used to amplify the bioelectric signal to obtain a first intermediate signal;

[0083] The bandpass filtering module is used to perform bandpass filtering on the first intermediate signal to obtain a second intermediate signal;

[0084] The analog-to-digital conversion module is used to perform analog-to-digital conversion processing on the second intermediate signal to obtain the digital signal to be tested.

[0085] Therefore, the signal acquisition circuit is designed to include an amplification module, a bandpass filtering module and an analog-to-digital conversion module, so that the process of converting the bioelectric signal into a digital signal to be tested covers the steps of amplification, filtering and analog-to-digital conversion. Specifically, the amplification module can enhance the amplitude of the bioelectric signal, making it easier to process and analyze, the bandpass filtering module can filter out interference and noise from the outside world, making the signal more reliable, and filtering can also highlight the signal within a specific frequency range, which is helpful for analyzing specific physiological phenomena. The analog-to-digital conversion module converts the continuous analog signal into a digital signal, so that the signal can be processed, stored and analyzed on a digital device. This digital signal is easier to process and can be further analyzed in a computer system. In summary, converting the bioelectric signal into a digital signal to be tested can reduce the error of the analog signal during transmission and processing, thereby improving the accuracy and reliability of the signal.

[0086] In some embodiments, multiple groups of electrode contacts are arranged along the length direction of the catheter, and each group of electrode contacts is evenly distributed along the circumference of the catheter.

[0087] In some embodiments, for each group of electrode contacts, while any one electrode contact delivers electrical stimulation to the patient's body tissue according to the stimulation pulse signal, it uses part or all of the other electrode contacts in the same group to collect the patient's bioelectric signals.

[0088] In some embodiments, the electrode wire is provided with 2 to 8 groups of electrode contacts, and each group of electrode contacts includes 1 to 9 electrode contacts.

[0089] The embodiment of the present application does not limit the number of groups of electrode contacts, which can be, for example, 3, 4, 5 or 8 groups, and the number of groups can be set according to the size of the electrode wire and the body tissue. Correspondingly, the number of electrode contacts in each group of electrode contacts is also not limited, which can be, for example, 2, 3, 4, 6 or 9.

[0090] Therefore, on the one hand, multiple stimulation contacts can be divided into multiple groups along the length direction of the catheter. By setting up segmented stimulation contacts, each group of stimulation contacts can achieve separate directional electrical stimulation, so that the electrical stimulation generated by them can be targeted at specific parts / directions for electrical stimulation, thereby reducing excessive treatment; on the one hand, multi-channel bioelectric signal acquisition and electrical stimulation can be performed, and combinations of different electrode contacts can be used for electrical stimulation and signal acquisition respectively, which helps to isolate electrical stimulation signals and bioelectric signals and reduce cross-interference. By evenly distributing multiple electrode contacts around the circumference of the catheter, better spatial resolution can be obtained, which helps to locate and analyze the signal source of the bioelectric signal; on the other hand, while one electrode contact delivers electrical stimulation, other electrode contacts are used to collect bioelectric signals, achieving the effect of stimulating and collecting at the same time, so that the bioelectric signals collected can better reflect the patient's actual EEG condition during electrical stimulation treatment.

[0091] In some embodiments, the electrode wire is provided with 4 groups of electrode contacts, and each group of electrode contacts includes 3 electrode contacts.

[0092] In the embodiment of the present application, a total of 4*3, i.e., 12 electrode contacts are provided on the electrode wire, wherein, in each group of electrode contacts, one contact is used for electrical stimulation, and the other two contacts are used for LFP signal acquisition. The first group of electrode contacts are sequentially recorded as 1a, 1b, and 1c, the second group of electrode contacts are sequentially recorded as 2a, 2b, and 2c, the third group of electrode contacts are sequentially recorded as 3a, 3b, and 3c, and the fourth group of electrode contacts are sequentially recorded as 4a, 4b, and 4c. 1a, 2a, 3a, and 4a are contacts in the same column along the axis of the slice-type electrode, 1b, 2b, 3b, and 4b are contacts in the same column along the axis of the slice-type electrode, and 1c, 2c, 3c, and 4c are contacts in the same column along the axis of the slice-type electrode.

[0093] Assuming that all 12 contacts are located in the nucleus, a fixed stimulation parameter (e.g., 4V, 100us, 150Hz) is used for round-robin stimulation, i.e., 1a stimulates and 1b and 1c collect, 1b stimulates and 1a and 1c collect, 1c stimulates and 1a and 1b collect, 2a stimulates and 2b and 2c collect, 2b stimulates and 2a and 2c collect, 2c stimulates and 2a and 2b collect, 3a stimulates and 3b and 3c collect, 3b stimulates and 3a and 3c collect, 3c stimulates and 3a and 3b collect, 4a stimulates and 4b and 4c collect, 4b stimulates and 4a and 4c collect, 4c stimulates and 4a and 4b collect, and 12 situations in total, each of which lasts for a preset time, including a state of no stimulation but only collecting and a state of stimulating and collecting at the same time. The preset time can be, for example, 1 minute, 2 minutes, or 4 minutes.

[0094] The bioelectric signal in the state of no stimulation and only collection is recorded as the first electrical signal, and the bioelectric signal in the state of stimulating and collecting is recorded as the second electrical signal. The bioelectric signal collected by the electrode contacts includes the first electrical signal and the second electrical signal.

[0095] Thus, each set of electrode contacts provides 3 electrodes, so a total of 12 electrode contacts are available, which enables the electrode wire to collect more channels of bioelectric signals at the same time, thereby providing richer and more comprehensive signal information. The 3 electrode contacts in each set of electrode contacts can collect signals at different angles and depths, which is very helpful for locating signal sources, analyzing signal changes, and studying the electrical activity characteristics of tissues in the body. By combining within each set of electrode contacts, a variety of stimulation modes can be achieved, such as selectively stimulating different areas, adjusting the stimulation intensity, etc., which is very valuable for some specific electrical stimulation therapy applications.

[0096] In some embodiments, the catheter is a rubber tube, the signal processing chip includes at least one bare chip, the signal processing chip is electrically connected to each electrode contact through a metal wire, and each bare chip is electrically connected to each other through a metal wire.

[0097] In some embodiments, the signal processing chip includes 1 to 10 bare chips.

[0098] The embodiment of the present application does not limit the number of bare chips, which may be, for example, 1, 2, 3, 4, 7 or 10.

[0099] When three bare chips are used, the bare chips can be assembled into a triangular prism structure, and when four bare chips are used, the bare chips can be assembled into a rectangular parallelepiped structure.

[0100] Bare chips, or bare DIE (Die-Only Chips), refer to exposed chips, that is, chips without packaging or packaging materials. Compared with traditional packaged chips, DIEs have smaller sizes and higher integration. They take up less space in electronic devices and provide faster data transmission speeds and lower energy consumption. The small size of bare chips allows for shorter signal transmission paths, thereby reducing the possibility of signal loss. In addition, since there is no packaging material (such as plastic or ceramic), bare chips have better high-frequency response and higher reliability.

[0101] In the embodiment of the present application, the metal wire can be a gold wire. The metal wire needs to connect the electrode contacts on the outer wall of the catheter and the bare chip inside the catheter. Therefore, the metal wire will directly contact the patient's internal tissue (nucleus). Gold wire is used. Gold has good electrical conductivity, which provides a guarantee for signal transmission, so that the bare chip can accurately read and transmit signals; and gold has strong antioxidant properties, which helps to maintain the long-term stability of the electrode wire; in addition, gold has good biocompatibility, which reduces the body's rejection of the electrode wire, avoids the electrode wire from triggering the patient's immune response or inflammatory response after being implanted in the brain, and improves safety and ease of use.

[0102] Therefore, the rubber tube as a catheter material has a certain flexibility and can adapt to the shapes of different organs and tissues. This flexibility helps to improve the patient's comfort and implant experience. Using metal wires to connect the signal processing chip and the electrode contacts can reduce the loss and interference of signal transmission. The metal wires can effectively transmit bioelectric signals and stimulation pulse signals, which helps to maintain the integrity of the signal. Each electrode contact is electrically connected to the signal processing chip, and the bare chips are also connected to each other through metal wires. The modular design of this chip makes subsequent maintenance, upgrades and replacements more convenient.

[0103] In some embodiments, the signal processing chip includes three bare chips, and the three bare chips form a triangular prism structure;

[0104] In some embodiments, an adhesive is filled between the signal processing chip and the inner wall of the catheter to fix the signal processing chip inside the catheter.

[0105] The embodiment of the present application does not limit the adhesive, and the adhesive can be glue.

[0106] As a result, the triangular prism structure can effectively utilize the internal space of the catheter, making the signal processing chip more stable in a limited space. This compact structure helps to simplify the layout of the electrode wires. Using an adhesive to fix the signal processing chip inside the catheter can prevent the signal processing chip from loosening or shifting during use, thereby improving the stability and reliability of the electrode wires. On the one hand, fixing the signal processing chip directly inside the catheter can optimize the signal transmission path, reduce signal transmission loss and interference, and thus improve signal quality. On the other hand, the signal processing chip is completely encapsulated inside the catheter, which can reduce the impact of the external environment on the signal processing chip and further improve the stability and accuracy of the signal.

[0107] In some embodiments, the patient's in vivo tissue includes the subthalamic nucleus, and the bioelectric signal includes a local field potential signal.

[0108] Therefore, the subthalamic nucleus is an important area in the brain, involved in a variety of neural functions, such as motor control and emotional regulation. By collecting local field potential signals, detailed information about the activity of the subthalamic nucleus can be obtained, which is helpful for studying its function and regulatory mechanism. In clinical applications, the treatment of specific patients (such as Parkinson's patients) may need to be adjusted according to their subthalamic nucleus activity. The collection of local field potential signals can provide important physiological information for individualized treatment. Through stimulation pulse signals, targeted electrical stimulation can be delivered to the subthalamic nucleus, which is of great help in the neuroregulatory treatment of Parkinson's patients.

[0109] In a specific application scenario, the present application provides an electrode lead, which includes a catheter, at least one electrode contact, and a signal processing chip:

[0110] Each electrode contact is attached to the outer wall of the catheter, and each electrode contact is used to collect bioelectric signals of the patient, and / or deliver electrical stimulation to the patient's body tissue according to the stimulation pulse signal, the patient's body tissue includes the subthalamic nucleus, and the bioelectric signals include local field potential signals;

[0111] The signal processing chip is arranged inside the catheter, and the signal processing chip integrates a signal analysis circuit and a signal acquisition circuit, wherein the signal analysis circuit is used to analyze the stimulation control instruction sent by the pulse generator and convert it into the stimulation pulse signal, and the signal acquisition circuit is used to convert the bioelectric signal collected by the electrode contact into a digital signal to be measured and output it;

[0112] Four groups of electrode contacts are arranged along the length direction of the catheter, each group of electrode contacts is evenly distributed along the circumference of the catheter, and each group of electrode contacts includes three electrode contacts;

[0113] For each group of electrode contacts, any one electrode contact, while delivering electrical stimulation to the patient's body tissue according to the stimulation pulse signal, uses part or all of the other electrode contacts in the same group to collect the patient's bioelectrical signals;

[0114] The catheter is a rubber tube, the signal processing chip includes three bare chips, and the three bare chips form a triangular prism structure; the signal processing chip is electrically connected to each electrode contact through a metal wire, and each bare chip is electrically connected to each other through a metal wire;

[0115] An adhesive is filled between the signal processing chip and the inner wall of the conduit so that the signal processing chip is fixed inside the conduit;

[0116] The signal acquisition circuit includes an amplification module, a bandpass filtering module and an analog-to-digital conversion module. The process of converting the bioelectric signal into a digital signal to be measured includes:

[0117] Amplifying the bioelectric signal using the amplification module to obtain a first intermediate signal;

[0118] Using the bandpass filtering module to perform bandpass filtering on the first intermediate signal to obtain a second intermediate signal;

[0119] The analog-to-digital conversion module is used to perform analog-to-digital conversion processing on the second intermediate signal to obtain the digital signal to be tested.

[0120] In one embodiment, consider introducing softer and more comfortable materials into the design of the catheter so as to better adapt to the patient's physiological structure, which can improve the comfort of wearing while reducing interference to biological tissues; for the signal processing chip, the signal analysis circuit and the signal acquisition circuit can be further optimized to achieve higher signal enhancement and noise reduction capabilities, improve the quality and accuracy of the signal, such as adding multiple stimulation modes so that the stimulator can work at different frequencies, amplitudes and durations, which can better meet the needs of different diseases or treatment goals; introduce a real-time feedback mechanism to convert the collected bioelectric signals into visual or auditory feedback, which can help patients or doctors better Better understand the patient's physiological state and stimulation effect; optimize the processor of the pulse generator so that it can adaptively adjust the stimulation parameters according to the real-time collected bioelectric signals to provide more accurate stimulation; introduce remote monitoring and control functions so that doctors or researchers can remotely adjust stimulation parameters, observe signal quality and perform real-time data analysis; consider using wireless communication technologies such as Bluetooth or Wi-Fi to achieve wireless connection with external devices and reduce the constraints of wires; optimize the selection of wire materials and shell materials to ensure long-term stability and biocompatibility; ensure that the signal acquisition, transmission and storage processes have sufficient data security measures to protect the privacy of patients.

[0121] Stimulator System Embodiments

[0122] See also Figure 3 , Figure 3 It is a schematic diagram of the principle of signal transmission of a stimulator system provided in an embodiment of the present application.

[0123] An embodiment of the present application further provides a stimulator system, which includes: a pulse generator and any of the above-mentioned electrode wires, wherein the pulse generator is electrically connected to a signal processing chip in the electrode wire.

[0124] In some embodiments, the pulse generator comprises a memory and at least one processor, the memory storing a computer program, and the at least one processor being configured to implement the following steps when executing the computer program:

[0125] Receiving the digital signal to be tested output by the signal processing chip;

[0126] According to the digital signal to be tested, a corresponding stimulation control instruction is generated, and the stimulation control instruction is output to the signal processing chip.

[0127] In some embodiments, the stimulator system further includes an extension wire, through which the pulse generator can be electrically connected to the signal processing chip (eg, Figure 1 The pulse generator can also be directly electrically connected to the signal processing chip (as shown in Figure 2 shown).

[0128] In some embodiments, the at least one processor is configured to further implement the following steps when executing the computer program:

[0129] Obtaining disease information of the patient;

[0130] According to the disease information and the digital signal to be tested, setting a first duration and a second duration corresponding to a signal acquisition period;

[0131] Wherein, during the first time period, at least one electrode contact is used to deliver electrical stimulation to the patient's body tissue while collecting the patient's bioelectrical signal;

[0132] During the second time period, bioelectric signals of the patient are collected using at least one electrode contact without delivering electrical stimulation.

[0133] In one embodiment, a pre-trained deep learning model can be used to set the corresponding first duration and second duration within the signal acquisition period according to the disease information and the digital signal to be tested.

[0134] In the embodiment of the present application, the first duration and the second duration together constitute a signal acquisition cycle. The first duration and the second duration may be equal or unequal. The first duration may be, for example, 1 minute, 2 minutes or 4 minutes, and the second duration may be, for example, 1 minute, 2 minutes or 4 minutes.

[0135] As an example, the first duration and the second duration are both 1 minute.

[0136] Assume that all 12 contacts are located in the nucleus, and the first group of contacts are 1a, 1b, and 1c, where in the first minute, 1a is stimulated and 1b and 1c are collected, in the second minute, 1a stops stimulating, and 1b and 1c are collected; then, in the third minute, 1b is stimulated and 1a and 1c are collected, in the fourth minute, 1b stops stimulating, and 1a and 1c are collected; then, in the fifth minute, 1c is stimulated and 1a and 1b are collected, in the sixth minute, 1c stops stimulating, and 1a and 1b are collected. And so on, until all contact groups have executed the dual collection mode of side stimulation and collection and no stimulation and only collection for each contact.

[0137] Therefore, according to the patient's disease information, combined with the digital signal to be tested, the first duration and the second duration of the signal acquisition cycle are set. In the first duration, the stimulator system collects bioelectric signals while delivering electrical stimulation through electrode contacts (stimulating while collecting), and in the second duration, the stimulator system only collects bioelectric signals without electrical stimulation (collecting without stimulation). In this way, the bioelectric signals of the patient when receiving electrical stimulation can be obtained, and the bioelectric signals of the patient when not receiving electrical stimulation can be obtained. The two bioelectric signals are analyzed and compared comprehensively to provide an accurate basis for closed-loop stimulation.

[0138] In a specific application scenario, the present application provides a stimulator system, the stimulator system comprising: a pulse generator and an electrode wire, the pulse generator being electrically connected to a signal processing chip in the electrode wire through the extension wire;

[0139] The pulse generator comprises a memory and at least one processor, wherein the memory stores a computer program, and the at least one processor is configured to implement the following steps when executing the computer program:

[0140] Receiving the digital signal to be tested output by the signal processing chip;

[0141] generating corresponding stimulation control instructions according to the digital signal to be tested, and outputting the stimulation control instructions to the signal processing chip;

[0142] Obtaining disease information of the patient;

[0143] According to the disease information and the digital signal to be tested, setting a first duration and a second duration corresponding to a signal acquisition period;

[0144] Wherein, during the first time period, at least one electrode contact is used to deliver electrical stimulation to the patient's body tissue while collecting the patient's bioelectrical signal;

[0145] During the second time period, bioelectric signals of the patient are collected using at least one electrode contact without delivering electrical stimulation.

[0146] In one embodiment, multiple sensors are added to the electrode wires to capture more bioelectric signals, such as electrocardiogram (ECG), electrooculogram (EOG), electromyography (EMG), etc., which can provide more comprehensive information for treatment; an adaptive energy management system is integrated into the stimulator system to intelligently distribute energy according to real-time energy demand, thereby improving battery life or the efficiency of wireless charging; ensuring that the patient's biological data is properly protected with privacy and security measures, while allowing patients and doctors to control the sharing and storage of data; enabling remote monitoring and data transmission of the stimulator system through a cloud platform, so that doctors can remotely adjust stimulation parameters and monitor the patient's status in real time; developing customized treatment plans for different types of diseases and individuals to ensure that the stimulator system can achieve the best results in a variety of situations; working closely with neuroscientists, clinicians, and engineers to ensure that the design and application of the stimulator system have practical feasibility and advantages in the fields of science, medicine, and engineering; and conducting long-term stability tests to ensure that the stimulator system remains stable and reliable during long-term use.

[0147] See also Figure 4 , Figure 4 It is a structural block diagram of a stimulator system provided in an embodiment of the present application.

[0148] The stimulator system may include, for example, at least one memory 11, at least one processor 12, and a bus 13 connecting different platform systems.

[0149] The memory 11 may include a readable medium in the form of a volatile memory, such as a random access memory (RAM) 111 and / or a cache memory 112 , and may further include a read-only memory (ROM) 113 .

[0150] The memory 11 also stores a computer program, which can be executed by the processor 12 so that the processor 12 implements the above steps.

[0151] The memory 11 may also include a utility 114 having at least one program module 115, such program module 115 including but not limited to: an operating system, one or more application programs, other program modules and program data, each of which or some combination may include the implementation of a network environment.

[0152] Accordingly, the processor 12 may execute the above-mentioned computer program and may execute the utility 114 .

[0153] The processor 12 may adopt one or more application specific integrated circuits (ASICs), DSPs, programmable logic devices (PLDs), complex programmable logic devices (CPLDs), field programmable gate arrays (FPGAs), or other electronic components.

[0154] The bus 13 may be a local bus representing one or more of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, a processor, or any of a variety of bus architectures.

[0155] The stimulator system can also communicate with one or more external devices such as keyboards, pointing devices, Bluetooth devices, etc., and can also communicate with one or more devices that can interact with the stimulator system, and / or communicate with any device (such as a router, a modem, etc.) that enables the stimulator system to communicate with one or more other computing devices. Such communication can be performed through the input and output interface 14. In addition, the stimulator system can also communicate with one or more networks (such as a local area network (LAN), a wide area network (WAN) and / or a public network, such as the Internet) through a network adapter 15. The network adapter 15 can communicate with other modules of the stimulator system through the bus 13. It should be understood that although not shown in the figure, other hardware and / or software modules can be used in conjunction with the stimulator system in actual applications, including but not limited to: microcode, device drivers, redundant processors, external disk drive arrays, RAID systems, tape drives, and data backup storage platforms.

[0156] Computer Readable Storage Medium Embodiments

[0157] The embodiment of the present application also provides a computer-readable storage medium, and its specific embodiment is consistent with the technical effects achieved by the above-mentioned embodiment, and some contents are not repeated here.

[0158] The computer-readable storage medium stores a computer program, and when the computer program is executed by at least one processor, the computer program implements the above steps or implements any one of the above functions of the stimulator.

[0159] Computer readable medium can be a computer readable signal medium or a computer readable storage medium. In an embodiment of the present application, a computer readable storage medium can be any tangible medium containing or storing a program, which can be used by an instruction execution system, device or device or used in combination with it. Computer readable storage medium can be, for example, but not limited to, a system, device or device of electricity, magnetism, light, electromagnetic, infrared, or semiconductor, or any combination of the above. More specific examples (non-exhaustive list) of computer readable storage medium include: an electrical connection with one or more wires, a portable disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above.

[0160] The computer-readable storage medium may include a data signal propagated in a baseband or as part of a carrier wave, wherein a readable program code is carried. Such propagated data signals may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. The computer-readable storage medium may also be any computer-readable medium that can send, propagate, or transmit a program for use by an instruction execution system, an apparatus, or a device or for use in combination with it. The program code contained on the computer-readable storage medium may be transmitted using any appropriate medium, including but not limited to wireless, wired, optical cable, RF, etc., or any suitable combination of the above. The program code for performing the operation of the present invention may be written in any combination of one or more programming languages, including object-oriented programming languages ​​such as Java, C++, etc., and also conventional procedural programming languages ​​such as C language or similar programming languages. The program code may be executed entirely on a user computing device, partially on a user device, as an independent software package, partially on a user computing device, partially on a remote computing device, or entirely on a remote computing device or server. Where a remote computing device is involved, the remote computing device may be connected to the user computing device through any type of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computing device (e.g., through the Internet using an Internet service provider).

[0161] Computer program product embodiments

[0162] The embodiment of the present application also provides a computer program product, and its specific embodiment is consistent with the technical effects achieved by the above-mentioned embodiment, and some contents are not repeated here.

[0163] The present application provides a computer program product, which includes a computer program. When the computer program is executed by at least one processor, the computer program implements the above steps or implements any one of the above functions of the stimulator.

[0164] See also Figure 5 , Figure 5 It is a structural diagram of a computer program product provided in an embodiment of the present application.

[0165] The computer program product is used to implement the steps of any of the above methods or to implement the functions of any of the above stimulators. The computer program product can adopt a portable compact disk read-only memory (CD-ROM) and include program code, and can be run on a terminal device, such as a personal computer. However, the computer program product of the present invention is not limited to this, and the computer program product can adopt any combination of one or more computer-readable media.

[0166] This application is explained from the perspectives of purpose of use, effectiveness, progress and novelty, and has met the functional enhancement and usage requirements emphasized by the Patent Law. The above description and drawings of this application are only the preferred embodiments of this application, and are not intended to limit this application. Therefore, all structures, devices, features, etc. that are similar or identical to this application, that is, all equivalent replacements or modifications made in accordance with the scope of the patent application of this application, should fall within the scope of protection of the patent application of this application.

Claims

1. An electrode lead, characterized in that: The electrode lead comprises a catheter, at least one electrode contact and a signal processing chip: Each electrode contact is attached to the outer wall of the catheter, and each electrode contact is used to collect bioelectric signals of the patient, and / or deliver electrical stimulation to the patient's body tissue according to the stimulation pulse signal; The signal processing chip is arranged inside the catheter.

2. The electrode lead according to claim 1, characterized in that: The signal processing chip integrates a signal analysis circuit and a signal acquisition circuit, wherein the signal analysis circuit is used to analyze the stimulation control instructions sent by the pulse generator and convert them into the stimulation pulse signal, and the signal acquisition circuit is used to convert the bioelectric signals collected by the electrode contacts into digital signals to be tested and output them.

3. The electrode lead according to claim 1, characterized in that: A plurality of groups of electrode contacts are arranged along the length direction of the catheter, and each group of electrode contacts is evenly distributed along the circumference of the catheter.

4. The electrode lead according to claim 3, characterized in that: For each group of electrode contacts, while any one electrode contact delivers electrical stimulation to the patient's body tissue according to the stimulation pulse signal, it uses part or all of the other electrode contacts in the same group to collect the patient's bioelectrical signals.

5. The electrode lead according to claim 3, characterized in that: The electrode wire is provided with 2 to 8 groups of electrode contacts.

6. The electrode lead according to claim 5, characterized in that: The electrode wire is provided with 4 groups of electrode contacts.

7. The electrode lead according to claim 3, characterized in that: Each group of electrode contacts includes 1 to 9 electrode contacts.

8. The electrode lead according to claim 7, characterized in that: Each set of electrode contacts includes 3 electrode contacts.

9. The electrode lead according to any one of claims 1 to 2, characterized in that: The catheter is a rubber tube, the signal processing chip includes at least one bare chip, the signal processing chip is electrically connected to each electrode contact through a metal wire, and each bare chip is electrically connected to each other through the metal wire.

10. The electrode lead according to claim 9, characterized in that: The signal processing chip includes 1 to 10 bare chips.

11. The electrode lead according to claim 10, characterized in that: The signal processing chip includes three bare chips.

12. The electrode lead according to claim 11, characterized in that: The three bare chips form a triangular prism structure.

13. The electrode lead according to claim 9, characterized in that: Adhesive is filled between the signal processing chip and the inner wall of the conduit so that the signal processing chip is fixed inside the conduit.

14. The electrode lead according to any one of claims 1 to 2, characterized in that: The signal acquisition circuit includes an amplification module, a bandpass filtering module and an analog-to-digital conversion module; The amplification module is used to amplify the bioelectric signal to obtain a first intermediate signal; The bandpass filtering module is used to perform bandpass filtering on the first intermediate signal to obtain a second intermediate signal; The analog-to-digital conversion module is used to perform analog-to-digital conversion processing on the second intermediate signal to obtain the digital signal to be tested.

15. The electrode lead according to any one of claims 1 to 2, characterized in that: The patient's in vivo tissue includes the subthalamic nucleus.

16. The electrode lead according to any one of claims 1 to 2, characterized in that: The bioelectric signal includes a local field potential signal.

17. A stimulator system, characterized in that The stimulator system comprises: a pulse generator and the electrode wire according to any one of claims 1 to 16, wherein the pulse generator is electrically connected to a signal processing chip in the electrode wire.

18. The stimulator system according to claim 17, characterized in that The pulse generator comprises a memory and at least one processor, wherein the memory stores a computer program, and the at least one processor is configured to implement the following steps when executing the computer program: Receiving the digital signal to be tested output by the signal processing chip; According to the digital signal to be tested, a corresponding stimulation control instruction is generated, and the stimulation control instruction is output to the signal processing chip.

19. The stimulator system according to claim 18, characterized in that The at least one processor is configured to further implement the following steps when executing the computer program: Obtaining disease information of the patient; According to the disease information and the digital signal to be tested, setting a first duration and a second duration corresponding to a signal acquisition period; Wherein, during the first time period, at least one electrode contact is used to deliver electrical stimulation to the patient's body tissue while collecting the patient's bioelectrical signal; During the second time period, bioelectric signals of the patient are collected using at least one electrode contact without delivering electrical stimulation.

20. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores a computer program, and when the computer program is executed by at least one processor, the function of the stimulator system according to any one of claims 17 to 19 is implemented.

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