Multi-channel functionalized gel microsphere generation device and application method thereof
By designing a multi-channel functionalized gel microsphere generation device, using the cross shearing effect driven by air pressure, the problems of poor uniformity in the preparation of gel microspheres, difficult to control particle size and high production costs in the prior art are solved, and efficient and simple gel microsphere generation is achieved.
Patent Information
- Application Number
- CN202411611012.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-12
- Publication Date
- 2025-03-07
AI Technical Summary
The existing gel microsphere preparation methods have poor uniformity, difficult to accurately control the particle size, and high production costs, and the traditional microfluidic control method is difficult to integrate and has low production efficiency.
A multi-channel functionalized gel microsphere generation device is designed, including a pressure control module, a gel microsphere generation module and a microsphere collection module. Through the combination of a double-layer flask and a side-opening pipeline array, the cross shearing of the continuous and dispersed phases is driven by the air pressure to form a monodispersed microemulsion, thereby generating gel microspheres.
It realizes efficient and simple generation of gel microspheres with high uniformity and controllable particle size, reducing production costs and solving the problems of high integration and low production efficiency in traditional methods.
Smart Images
Figure CN119565516A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of gel microsphere preparation, in particular to a multi-channel functionalized gel microsphere generating device and an application method thereof. Background Art
[0002] Existing methods for preparing functionalized gel microspheres include traditional solvent evaporation, phase separation, spray drying, emulsion polymerization, mechanical stirring shearing, microfluidics, and membrane emulsification. Traditional methods can prepare gel microspheres on a large scale, but the uniformity is poor, and the particle size cannot be accurately controlled. It also requires additional filtration processes, which results in waste of raw materials and reduces utilization. The membrane emulsification method can achieve higher uniformity, but its microsphere formation mechanism mainly depends on the microscale range dominated by interfacial tension, so the particle size controllable range is small; in addition, the membrane emulsification method can achieve mass production mainly because of the thousands of micropores on the surface of the porous membrane tube, and the generation efficiency of a single channel is not high, which makes the cost of the porous membrane tube very expensive. The damage or blockage of individual holes will cause the entire membrane tube to be scrapped, further increasing the production cost. The microfluidics method can achieve the best uniformity among all methods, and the microsphere generation efficiency of a single channel is high, but the integration is difficult, and the overall production efficiency is not as good as the membrane emulsification method. Summary of the invention
[0003] In view of this, the embodiments of the present invention provide a multi-channel functionalized gel microsphere generating device and an application method thereof, which can efficiently and conveniently prepare gel microspheres.
[0004] On the one hand, an embodiment of the present invention provides a multi-channel functionalized gel microsphere generating device, comprising an air pressure control module, a gel microsphere generating module and a microsphere collecting module;
[0005] The gel microsphere generation module comprises a double-layer bottle and a side opening pipe array; the double-layer bottle comprises an inner bottle and an outer bottle, the inner bottle is used to load a continuous phase solution, and the outer bottle is used to load a dispersed phase solution; the input port of the side opening pipe array is connected to the inner bottle, and the output port of the side opening pipe array passes through the bottom of the outer bottle and is connected to the outside of the double-layer bottle and connected to the microsphere collection module; the side openings of the side opening pipe array are arranged inside the outer bottle; the top of the double-layer bottle is provided with a first gas circuit input interface and a second gas circuit input interface, the first gas circuit input interface is connected to the outer bottle, and the second gas circuit input interface is connected to the inner bottle;
[0006] The air pressure control module is used to adjust the air pressure in the gel microsphere generating module, and the microsphere collecting module is used to load the solution after the curing reaction is completed to generate gel microspheres.
[0007] Optionally, the air pressure control module includes an air compressor, a buffer gas tank, a first output gas path, and a second output gas path;
[0008] The air compressor is connected to a buffer gas tank, which is used to store compressed air; one end of the first output gas circuit is connected to the buffer gas tank, and the other end of the first output gas circuit is connected to the first gas circuit input interface; one end of the second output gas circuit is connected to the buffer gas tank, and the other end of the second output gas circuit is connected to the second gas circuit input interface.
[0009] Optionally, the air pressure control module further includes a first pressure regulating valve and a second pressure regulating valve; the first pressure regulating valve is arranged in the first output air path, and the second pressure regulating valve is arranged in the second output air path.
[0010] Optionally, the side openings of the side opening pipe array have an aperture range of 0.01 mm to 0.3 mm.
[0011] Optionally, the inner diameter of the tubes of the side opening tube array ranges from 0.1 mm to 1 mm.
[0012] Optionally, the pipes of the side opening pipe array are made of rigid materials, including stainless steel, quartz glass and organic glass.
[0013] Optionally, the microsphere collection module comprises a collection container and an ultraviolet light source; a certain amount of continuous phase solution is loaded in the collection container; the output port of the side opening pipe array is connected to the collection container and submerged below the liquid level of the continuous phase solution;
[0014] The collection container is used to load the solution after the reaction is completed and the generated gel microspheres;
[0015] The ultraviolet light source is used to solidify the reaction-completed solution to form gel microspheres.
[0016] On the other hand, an embodiment of the present invention provides a method for generating multi-channel functionalized gel microspheres, which is used in the above multi-channel functionalized gel microsphere generating device, and the method comprises:
[0017] preparing a continuous phase solution and a dispersed phase solution;
[0018] The continuous phase solution is placed in the inner bottle of the double-layer bottle; the dispersed phase solution is placed in the outer bottle of the double-layer bottle;
[0019] The air pressure of the inner bottle and the outer bottle in the gel microsphere generation module are adjusted respectively by the air pressure control module;
[0020] Based on the air pressure driving, the continuous phase solution enters the pipeline from the input port of the side opening pipeline array and flows along the inside of the pipeline; based on the air pressure driving, the dispersed phase solution enters the pipeline from the side opening of the side opening pipeline array and intersects with the continuous phase solution vertically, and forms a monodisperse microemulsion under the action of the lateral shear force of the continuous phase solution;
[0021] The solidified microemulsion is loaded into the microsphere collection module to generate gel microspheres.
[0022] Optionally, the air pressure control module includes an air compressor, a buffer gas tank, a first output gas circuit and a second output gas circuit; the air compressor is connected to the buffer gas tank, and the buffer gas tank is used to store compressed air; one end of the first output gas circuit is connected to the buffer gas tank, and the other end of the first output gas circuit is connected to the first gas circuit input interface; one end of the second output gas circuit is connected to the buffer gas tank, and the other end of the second output gas circuit is connected to the second gas circuit input interface; the air pressure control module also includes a first pressure regulating valve and a second pressure regulating valve; the first pressure regulating valve is arranged in the first output gas circuit, and the second pressure regulating valve is arranged in the second output gas circuit; the air pressure of the reaction environment of the inner bottle and the outer bottle in the gel microsphere generation module is adjusted respectively by the air pressure control module, including:
[0023] Start the air compressor to fill the buffer gas tank with compressed gas;
[0024] The pressure values of the first pressure regulating valve and the second pressure regulating valve are respectively set.
[0025] Optionally, the microsphere collection module includes a collection container and an ultraviolet light source; and the microsphere collection module is loaded with the solidified microemulsion to generate gel microspheres, comprising:
[0026] loading the microemulsion through a collection vessel;
[0027] The ultraviolet light source is activated to cure the microemulsion to generate gel microspheres.
[0028] The embodiment of the present invention proposes a multi-channel functionalized gel microsphere generating device, comprising an air pressure control module, a gel microsphere generating module and a microsphere collecting module; the gel microsphere generating module comprises a double-layer bottle and a side opening pipe array; the double-layer bottle comprises an inner bottle and an outer bottle, the inner bottle is used to load a continuous phase solution, and the outer bottle is used to load a dispersed phase solution; the input port of the side opening pipe array is connected to the inner bottle, and the output port of the side opening pipe array passes through the bottom of the outer bottle and is connected to the outside of the double-layer bottle and connected to the microsphere collecting module; the side openings of the side opening pipe array are arranged inside the outer bottle; a first air circuit input interface and a second air circuit input interface are arranged on the top of the double-layer bottle, the first air circuit input interface is connected to the outer bottle, and the second air circuit input interface is connected to the inner bottle; the air pressure control module is used to adjust the air pressure in the gel microsphere generating module, and the microsphere collecting module is used to load the solution after the curing reaction is completed to generate gel microspheres. The embodiment of the present invention uses a pipe array of multiple pipes with side openings to encapsulate them in a double-layer bottle, forming two independent closed spaces, an outer bottle area and an inner bottle area, and an open area for the output pipeline. Finally, air pressure is used to drive the fluid through cross-shearing to achieve continuous large-scale generation of monodisperse functionalized gel microspheres, thereby solving the problems of difficult integration and low production efficiency of traditional microfluidic methods. BRIEF DESCRIPTION OF THE DRAWINGS
[0029] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
[0030] Figure 1 A schematic diagram of the structure of a multi-channel functionalized gel microsphere generating device provided in an embodiment of the present invention;
[0031] Figure 2 A schematic diagram of the structure of a gel microsphere generation module provided in an embodiment of the present invention;
[0032] Figure 3 A schematic diagram of an application method of a multi-channel functionalized gel microsphere generating device provided by an embodiment of the present invention;
[0033] Figure 4 A schematic diagram of a product example of gel microspheres generated according to an embodiment of the present invention. DETAILED DESCRIPTION
[0034] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.
[0035] On the one hand, an embodiment of the present invention provides a multi-channel functionalized gel microsphere generating device, comprising an air pressure control module, a gel microsphere generating module and a microsphere collecting module;
[0036] The gel microsphere generation module comprises a double-layer bottle and a side opening pipe array; the double-layer bottle comprises an inner bottle and an outer bottle, the inner bottle is used to load a continuous phase solution, and the outer bottle is used to load a dispersed phase solution; the input port of the side opening pipe array is connected to the inner bottle, and the output port of the side opening pipe array passes through the bottom of the outer bottle and is connected to the outside of the double-layer bottle and connected to the microsphere collection module; the side openings of the side opening pipe array are arranged inside the outer bottle; the top of the double-layer bottle is provided with a first gas circuit input interface and a second gas circuit input interface, the first gas circuit input interface is connected to the outer bottle, and the second gas circuit input interface is connected to the inner bottle;
[0037] The air pressure control module is used to adjust the air pressure in the gel microsphere generating module, and the microsphere collecting module is used to load the solution after the curing reaction is completed to generate gel microspheres.
[0038] In some embodiments, the air pressure control module includes an air compressor, a buffer gas tank, a first output gas path, and a second output gas path;
[0039] The air compressor is connected to a buffer gas tank, which is used to store compressed air; one end of the first output gas circuit is connected to the buffer gas tank, and the other end of the first output gas circuit is connected to the first gas circuit input interface; one end of the second output gas circuit is connected to the buffer gas tank, and the other end of the second output gas circuit is connected to the second gas circuit input interface.
[0040] In some embodiments, the air pressure control module further includes a first pressure regulating valve and a second pressure regulating valve; the first pressure regulating valve is disposed in the first output air path, and the second pressure regulating valve is disposed in the second output air path.
[0041] In some embodiments, the side openings of the side opening channel array have a hole diameter ranging from 0.01 mm to 0.3 mm.
[0042] In some embodiments, the inner diameter of the tubes of the side opening tube array ranges from 0.1 mm to 1 mm.
[0043] In some embodiments, the tubes of the side opening tube array are made of rigid materials, including stainless steel, quartz glass, and organic glass.
[0044] In some embodiments, the microsphere collection module includes a collection container and an ultraviolet light source; a certain amount of continuous phase solution is loaded in the collection container; the output port of the side opening pipe array is connected to the collection container and submerged below the liquid level of the continuous phase solution;
[0045] The collection container is used to load the solution after the reaction is completed and the generated gel microspheres;
[0046] The ultraviolet light source is used to solidify the reaction-completed solution to form gel microspheres.
[0047] For example, in some specific embodiments, Figure 1 As shown, a multi-channel functionalized gel microsphere generating device provided by an embodiment of the present invention includes an air pressure control module 1-1, a gel microsphere generating module 1-2 and a microsphere collecting module 1-3.
[0048] The air pressure control module includes an air compressor, a buffer gas tank, a first pressure regulating valve, a second pressure regulating valve, a first output gas path, and a second output gas path. The air compressor is connected to the buffer gas tank, which is used to store compressed air to reduce air pressure fluctuations. The buffer gas tank outputs two gas paths, namely the first output gas path and the second output gas path. The output pressures of the two output gas paths are independently controlled by the first pressure regulating valve and the second pressure regulating valve.
[0049] Among them, Figure 2As shown, the gel microsphere generation module includes a side opening pipe array 2-1, a double-layer bottle 2-2, a first gas path input interface 2-3 and a second gas path input interface 2-4. The side opening pipe array is a plurality of straight pipes with side openings 2-1-1 arranged in combination at a certain interval, the aperture range of the side openings 2-1-1 is 0.01 to 0.3 mm, and the inner diameter range of the straight pipe is 0.1 to 1 mm; the straight pipe is made of stainless steel, quartz glass and organic glass;
[0050] The double-layer bottle comprises an inner bottle and an outer bottle, and the double-layer bottle is tightly matched with a side opening pipe array, the side opening is located inside the outer bottle, i.e., the outer bottle area, for loading the dispersed phase solution; the input port of the pipe array is located at the bottom of the inner bottle, i.e., the inner bottle area, for loading the continuous phase solution;
[0051] The top of the double-layer bottle is provided with a first gas circuit input interface and a second gas circuit input interface. The first gas circuit input interface is connected to the outer bottle and is used to control the pressure of the outer bottle area; the second gas circuit input interface is connected to the inner bottle and is used to control the pressure of the inner bottle area;
[0052] The microsphere collection module includes a collection container and an ultraviolet light source. A certain amount of continuous phase solution is loaded in the collection container and the outlet of the side opening pipe array is submerged below the liquid surface; the ultraviolet light source is used to solidify the generated microemulsion to form gel-state microspheres.
[0053] On the other hand, an embodiment of the present invention provides a method for generating multi-channel functionalized gel microspheres, which is used in the above method for generating multi-channel functionalized gel microspheres, and the method comprises:
[0054] preparing a continuous phase solution and a dispersed phase solution;
[0055] The continuous phase solution is placed in the inner bottle of the double-layer bottle; the dispersed phase solution is placed in the outer bottle of the double-layer bottle;
[0056] The air pressure of the inner bottle and the outer bottle in the gel microsphere generation module are adjusted respectively by the air pressure control module;
[0057] Based on the air pressure driving, the continuous phase solution enters the pipeline from the input port of the side opening pipeline array and flows along the inside of the pipeline; based on the air pressure driving, the dispersed phase solution enters the pipeline from the side opening of the side opening pipeline array and intersects with the continuous phase solution vertically, and forms a monodisperse microemulsion under the action of the lateral shear force of the continuous phase solution;
[0058] The solidified microemulsion is loaded into the microsphere collection module to generate gel microspheres.
[0059] like Figure 4 As shown, taking the high-throughput preparation of PEG gel microspheres as an example, Figure 4 Examples of gel microspheres with different particle sizes prepared using the device are shown in the figure.
[0060] Optionally, the air pressure control module includes an air compressor, a buffer gas tank, a first output gas circuit and a second output gas circuit; the air compressor is connected to the buffer gas tank, and the buffer gas tank is used to store compressed air; one end of the first output gas circuit is connected to the buffer gas tank, and the other end of the first output gas circuit is connected to the first gas circuit input interface; one end of the second output gas circuit is connected to the buffer gas tank, and the other end of the second output gas circuit is connected to the second gas circuit input interface; the air pressure control module also includes a first pressure regulating valve and a second pressure regulating valve; the first pressure regulating valve is arranged in the first output gas circuit, and the second pressure regulating valve is arranged in the second output gas circuit; the air pressure of the reaction environment of the inner bottle and the outer bottle in the gel microsphere generation module is adjusted respectively by the air pressure control module, including:
[0061] Start the air compressor to fill the buffer gas tank with compressed gas;
[0062] The pressure values of the first pressure regulating valve and the second pressure regulating valve are respectively set.
[0063] Optionally, the microsphere collection module includes a collection container and an ultraviolet light source; and the microsphere collection module is loaded with the solidified microemulsion to generate gel microspheres, comprising:
[0064] loading the microemulsion through a collection vessel;
[0065] The ultraviolet light source is activated to cure the microemulsion to generate gel microspheres.
[0066] For example, in some specific embodiments, the multi-channel functionalized gel microsphere generation method provided in the embodiments of the present invention is applied to the multi-channel functionalized gel microsphere generation device described above, such as Figure 3 As shown, the application principle of the multi-channel functionalized gel microsphere generation device is as follows:
[0067] preparing a continuous phase solution and a dispersed phase solution;
[0068] The continuous phase solution 3-1 and the dispersed phase solution 3-2 are respectively placed in the inner bottle and the outer bottle of the double-layer bottle;
[0069] Turn on the air compressor to fill the buffer gas tank with compressed gas, and set the pressure values of the first pressure regulating valve and the second pressure regulating valve respectively;
[0070] The pressure limiting valve is opened to allow the continuous phase solution in the inner bottle to enter from the input port of the side opening pipe array based on air pressure and flow along the inside of the pipe, while the dispersed phase solution is driven by air pressure to enter the pipe from the side holes of the side opening pipe array and intersect perpendicularly with the continuous phase solution, and a monodispersed microemulsion 3-3 is formed under the action of the lateral shear force of the continuous phase, and enters the collection container along the pipe outlet;
[0071] The ultraviolet light source is turned on to solidify the microemulsion 3-3 containing the photoinitiator component settled in the collection container into gel microspheres 3-4 through photocrosslinking.
[0072] The following is a detailed description of the process steps of the multi-channel functionalized gel microsphere generation method of the present invention in combination with specific example data:
[0073] 1. Prepare the continuous phase solution: add 90 mL of paraffin oil to a beaker, then add 10 mL of surfactant solution, and then stir and mix with a magnetic stirrer for more than 30 minutes to obtain a continuous phase mixed liquid; the surfactant is one or more of span 60, span 65, span 80 or span 85;
[0074] 2. Prepare dispersed phase solution: weigh 1 gram of methacrylated gelatin freeze-dried product and put it into a centrifuge tube, then weigh 0.025 gram of LAP photoinitiator and put it into the centrifuge tube where the gelatin is located, add 10 mL of 1xPBS buffer solution into the centrifuge tube, and fully shake and dissolve in a 50°C water bath to obtain a dispersed phase solution;
[0075] 3. Place the continuous phase solution and the dispersed phase solution into the inner bottle and outer bottle of the double-layer bottle respectively;
[0076] 4. Turn on the air compressor to fill the buffer gas tank with compressed gas, and set the pressure values of the first pressure regulating valve and the second pressure regulating valve to 5kPa and 6kPa respectively;
[0077] 5. Open the pressure-limiting valve to allow the continuous phase solution in the inner bottle to enter from the input port of the side opening pipe array based on air pressure and flow along the inside of the pipe, and at the same time, allow the dispersed phase solution to enter the pipe from the side holes of the side opening pipe array based on air pressure and intersect with the continuous phase solution vertically, and form a monodisperse microemulsion under the action of the lateral shear force of the continuous phase, and enter the collection container along the pipe outlet;
[0078] 6. Turn on the ultraviolet light source to solidify the microemulsion containing the photoinitiator component settled in the collection container into gel microspheres through photocrosslinking.
[0079] The present invention provides a multi-channel functionalized gel microsphere generating device and an application method thereof. The device is mainly based on a plurality of straight pipes with side openings, which are encapsulated in a double-layer bottle to form two independent closed spaces, an outer bottle area and an inner bottle area, and an open area for an output pipeline. Finally, air pressure is used to drive the fluids in the microporous area and the input area to achieve continuous large-scale generation of monodisperse functionalized gel microspheres through cross shearing, thereby solving the problems of difficult integration and low production efficiency of traditional microfluidic methods.
[0080] Compared with the prior art, the present invention includes at least the following beneficial effects: The embodiment of the present invention is based on the combination of multiple side opening pipes and double-layer bottles to form a synchronous parallel cross-flow microfluidic array, which can produce gel microspheres in large quantities. By adjusting the specifications of the pipes and openings, as well as the size of the air pressure, the size of the generated microspheres can be accurately controlled. The device has a simple structure and is easy to operate. Most importantly, unlike other capillary-based microfluidic devices, this solution does not require alignment and calibration of the pipelines, which reduces the difficulty of manufacturing the device and has great application prospects in the field of microsphere preparation.
[0081] In some selectable embodiments, the function / operation mentioned in the block diagram may not occur in the order mentioned in the operation diagram. For example, depending on the function / operation involved, the two boxes shown in succession can actually be executed substantially simultaneously or the boxes can sometimes be executed in reverse order. In addition, the embodiment presented and described in the flow chart of the present invention is provided by way of example, for the purpose of providing a more comprehensive understanding of technology. The disclosed method is not limited to the operation and logic flow presented herein. Selectable embodiments are expected, wherein the order of various operations is changed and the sub-operation of a part for which is described as a larger operation is performed independently.
[0082] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.
[0083] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.
[0084] The above is a specific description of the preferred implementation of the present invention, but the present invention is not limited to the embodiments. Those skilled in the art can make various equivalent modifications or substitutions without violating the spirit of the present invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.
Claims
1. A multi-channel functionalized gel microsphere generating device, characterized in that: It includes an air pressure control module, a gel microsphere generation module and a microsphere collection module; The gel microsphere generation module comprises a double-layer bottle and a side opening pipe array; the double-layer bottle comprises an inner bottle and an outer bottle, the inner bottle is used to load a continuous phase solution, and the outer bottle is used to load a dispersed phase solution; the input port of the side opening pipe array is connected to the inner bottle, and the output port of the side opening pipe array passes through the bottom of the outer bottle and is connected to the outside of the double-layer bottle and connected to the microsphere collection module; the side openings of the side opening pipe array are arranged inside the outer bottle; the top of the double-layer bottle is provided with a first gas circuit input interface and a second gas circuit input interface, the first gas circuit input interface is connected to the outer bottle, and the second gas circuit input interface is connected to the inner bottle; The air pressure control module is used to adjust the air pressure in the gel microsphere generating module, and the microsphere collecting module is used to load the solution after the curing reaction is completed to generate gel microspheres.
2. The multi-channel functionalized gel microsphere generating device according to claim 1, characterized in that: The air pressure control module includes an air compressor, a buffer gas tank, a first output gas path and a second output gas path; The air compressor is connected to the buffer gas tank, and the buffer gas tank is used to store compressed air; One end of the first output gas circuit is connected to the buffer gas tank, and the other end of the first output gas circuit is connected to the first gas circuit input interface; One end of the second output gas circuit is connected to the buffer gas tank, and the other end of the second output gas circuit is connected to the second gas circuit input interface.
3. The multi-channel functionalized gel microsphere generating device according to claim 2, characterized in that: The air pressure control module further includes a first pressure regulating valve and a second pressure regulating valve; the first pressure regulating valve is arranged on the first output air path, and the second pressure regulating valve is arranged on the second output air path.
4. The multi-channel functionalized gel microsphere generating device according to claim 1, characterized in that: The apertures of the side openings of the side opening pipe array range from 0.01 mm to 0.3 mm.
5. The multi-channel functionalized gel microsphere generating device according to claim 1, characterized in that: The inner diameter of the pipes of the side opening pipe array ranges from 0.1 mm to 1 mm.
6. The multi-channel functionalized gel microsphere generating device according to claim 1, characterized in that: The pipes of the side opening pipe array are made of rigid materials, including stainless steel, quartz glass and organic glass.
7. The multi-channel functionalized gel microsphere generating device according to claim 1, characterized in that: The microsphere collection module comprises a collection container and an ultraviolet light source; a certain amount of the continuous phase solution is loaded in the collection container; the output port of the side opening pipe array is connected to the collection container and submerged below the liquid level of the continuous phase solution; The collection container is used to load the solution after the reaction and the generated gel microspheres; The ultraviolet light source is used to solidify the solution after the reaction is completed to form the gel microspheres.
8. An application method of a multi-channel functionalized gel microsphere generating device, applied to the multi-channel functionalized gel microsphere generating device according to any one of claims 1 to 7, characterized in that: The method comprises: preparing a continuous phase solution and a dispersed phase solution; The continuous phase solution is placed in the inner bottle of a double-layer bottle; the dispersed phase solution is placed in the outer bottle of the double-layer bottle; The air pressure of the inner bottle and the outer bottle in the gel microsphere generating module are respectively adjusted by an air pressure control module; The continuous phase solution is driven by air pressure to enter the pipeline from the input port of the side opening pipeline array and flow along the inside of the pipeline; the dispersed phase solution is driven by air pressure to enter the pipeline from the side openings of the side opening pipeline array and intersect the continuous phase solution perpendicularly, and a monodispersed microemulsion is formed under the action of the lateral shear force of the continuous phase solution; The microemulsion is loaded and solidified through a microsphere collection module to generate gel microspheres.
9. The multi-channel functionalized gel microsphere generating device according to claim 8, characterized in that: The air pressure control module includes an air compressor, a buffer gas tank, a first output gas path and a second output gas path; the air compressor is connected to the buffer gas tank, and the buffer gas tank is used to store compressed air; One end of the first output gas circuit is connected to the buffer gas tank, and the other end of the first output gas circuit is connected to the first gas circuit input interface; one end of the second output gas circuit is connected to the buffer gas tank, and the other end of the second output gas circuit is connected to the second gas circuit input interface; The air pressure control module further includes a first pressure regulating valve and a second pressure regulating valve; the first pressure regulating valve is arranged in the first output air path, and the second pressure regulating valve is arranged in the second output air path; the air pressure control module is used to adjust the air pressure of the reaction environment of the inner bottle and the outer bottle in the gel microsphere generation module respectively, including: Starting the air compressor to fill the buffer gas tank with compressed gas; The pressure values of the first pressure regulating valve and the second pressure regulating valve are respectively set.
10. The multi-channel functionalized gel microsphere generating device according to claim 8, characterized in that: The microsphere collection module includes a collection container and an ultraviolet light source; The step of loading and curing the microemulsion to generate gel microspheres through a microsphere collection module comprises: loading the microemulsion via the collection vessel; The ultraviolet light source is activated to cure the microemulsion to generate the gel microspheres.