Anti-acne composition

Abstract

The present invention relates to a composition having anti-acne benefits comprising a) at least 88% by weight of water; b) at least 0.5% by weight of a nonionic surfactant having an HLB of at least 15.7; and c) an anti-acne agent.

Description

Technical Field

[0001] The present invention relates to topical compositions that provide anti-acne benefits without the need for traditional topical ointments. More specifically, the present invention relates to compositions comprising at least 88% by weight of water, and at least 0.5% by weight of a nonionic surfactant having an HLB value of at least 15.7, and an anti-acne agent. Background Art

[0002] The present invention is directed to topical compositions and methods for reducing, treating, controlling and / or preventing the occurrence of acne on the skin.

[0003] Acne, also known as acne vulgaris, is a common skin condition that affects nearly all adolescents and adults at some point in their lives. It has a complex etiology involving abnormal keratinization, excess sebum production, androgen function, bacterial growth, and immune hypersensitivity. Other factors associated with acne are the presence of free radicals with subsequent oxidative stress that lead to cell damage.

[0004] The earliest acne lesions are called microcomedones. These develop into comedones, which can be open ("blackheads") or closed ("whiteheads"). The various stages of acne have been classified as comedones, papules, pustule, and cyst.

[0005] It has been observed that acne often occurs in areas rich in sebaceous glands, such as the face, neck and back. The bacterium Propionibacterium acne (P. acnes) has also been implicated in the development of acne.

[0006] Many products are marketed for the treatment of acne, including the ingestion of pills and the topical application of ointments (e.g., gels and creams). Generally, anti-acne agents such as salicylic acid are known to be used for topical application; however, salicylic acid is also known to be difficult to formulate, particularly in water-based products. Topical application is popular among consumers, but continuous and repeated use of such products can lead to dry and irritated skin, which is usually a result of the anti-acne agent. Therefore, there is still a need to locally deliver the benefits of anti-acne agents such as salicylic acid without adverse side effects.

[0007] Micellar water is a product known as a gentle and mild cleanser. It is popular among consumers because it can clean the skin quickly and easily without the need for rinsing. In addition, micellar water is well suited to many skin types, including dry and oily skin. Therefore, micellar water is often used to remove substances from the skin, including dirt, oil and makeup, and can help promote skin clarity, but for many consumers, acne is still a problem and additional topical treatments need to be applied to acne as well.

[0008] The inventors of the present application unexpectedly discovered that anti-acne agents can be included in micellar waters, allowing consumers to treat acne while lessening the adverse side effects from conventional topical ointments (e.g., gels and creams). In other words, it was unexpectedly discovered that clear and stable micellar waters with anti-acne agents (e.g., salicylic acid) can be obtained that provide a softer and gentler form for reducing, treating, controlling and / or preventing the occurrence of acne. Summary of the invention

[0009] In a first aspect, the composition comprises (a) at least 88 wt% water, preferably 88 to 94 wt% water; (b) at least 0.5 wt% nonionic surfactant having an HLB of at least 15.7; and (c) an anti-acne agent.

[0010] In a second aspect, is a method for reducing, treating, controlling and / or preventing the occurrence of acne, the method comprising: (a) applying a composition to the surface of the skin, the composition comprising (i) at least 88% by weight of water, preferably 88% to 94% by weight of water; (ii) at least 0.5% by weight of a nonionic surfactant having an HLB of at least 15.7; and (iii) an anti-acne agent; and (b) optionally, rubbing the composition into the surface of the skin. Optionally, the method can be repeated daily, or twice a day or three times a day.

[0011] In another aspect are methods of providing anti-acne benefits to the skin after applying a composition disclosed herein to a skin surface in need thereof.

[0012] In yet another aspect is the use of a composition as disclosed herein for reducing, treating, controlling and / or preventing acne. In another aspect is the use of a composition as disclosed herein for obtaining an anti-acne benefit.

[0013] All other aspects of the invention will become more readily apparent from the description and examples which follow. DETAILED DESCRIPTION

[0014] Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reactions, physical properties of materials and / or use may optionally be understood as modified by "about".

[0015] Unless otherwise indicated, all amounts are by weight of any composition or component thereof.It should be noted that in specifying any range of values, any particular upper value can be associated with any particular lower value.

[0016] For the avoidance of doubt, the term "comprising" is not meant to be limited to any stated elements, but rather encompasses unspecified elements of major or minor functional importance. Therefore, the listed steps, elements or options are not necessarily exhaustive. Whenever the words "including" or "having" are used, these terms are meant to be equivalent to "comprising" as defined above.

[0017] The disclosure as found herein is deemed to cover all embodiments found in the claims to be multiply dependent on each other, regardless of the fact that the claims may be found without multiple dependency or redundancy.

[0018] "Skin" as used herein includes the skin on the face, neck, chest, back, arms (including the underarms), armpits, buttocks, hands, legs, and scalp.

[0019] As used herein, "acne" refers to, for example, acne lesions, such as microcomedones, open comedones ("blackheads"), closed comedones ("whiteheads"), papules, pustules, and cysts. Treating, preventing, controlling, and / or reducing acne may involve the appearance of acne lesions on the surface of the skin and / or reducing the appearance of acne lesions on the surface of the skin (e.g., the size, type, and / or color of the lesions) and / or the number of acne lesions on the skin. As used herein, "anti-acne benefit" may mean killing bacteria known to cause acne, reducing the number of acne lesions, reducing the appearance of acne lesions on the skin, removing excess oil from the skin, promoting the growth of new skin cells, and / or the removal of dead skin cells.

[0020] As used herein, skin benefit agents refer to improvements in facial or body features following topical application, such as even skin tone, wrinkle reduction, and the like.

[0021] As used herein, "derivative(s)" refers to substitutions of functional groups on a compound.

[0022] As used herein, "micelle" is an aggregate assembly of surfactant molecules dispersed in a liquid (e.g., water). As used herein, "micelle water" is a stable dispersion or emulsion, which is usually transparent and / or translucent, which contains micelles. As used herein, "stable" means that micellar water is a continuous (single-phase) aqueous phase rather than, for example, a two-phase composition.

[0023] In a first aspect, the composition comprises (a) at least 88 wt% water, preferably 88 to 94 wt% water; (b) at least 0.5 wt% nonionic surfactant having an HLB of at least 15.7; and (c) an anti-acne agent. In one aspect, the composition is micellar water.

[0024] In one aspect, the amount of water included is at least 88%, or at least 89%, or at least 90%, or at least 91%, or at least 92%, or at least 93%, but no more than 94% water, by weight of the composition described herein. In one aspect, the amount of water included is from about 88% to about 94%, or from about 88% to about 93%, or from about 89% to about 94%, or from about 89% to about 93%, or from about 90% to about 94%, or from about 90% to about 93%, including all ranges and amounts contained therein, by weight of the composition described herein.

[0025] In one aspect, the composition as described herein contains a nonionic surfactant having an HLB of at least 15.7. In one aspect, the HLB of the nonionic surfactant is from about 15.7 to about 18, or from about 15.7 to about 17.5, or from about 15.7 to about 16.9. In one aspect, the nonionic surfactant having an HLB of at least 15.7 is ceteth-20, laureth-23, polysorbate-20, and / or mixtures thereof, preferably polysorbate-20.

[0026] In one aspect, the amount of nonionic surfactants with an HLB of at least 15.7 included is at least 0.5%, or at least 0.75%, or at least 1%, or at least 1.25%, or at least 1.5%, by weight of the composition described herein. On the other hand, the amount of nonionic surfactants with an HLB of at least 15.7 included is from about 0.5% to about 4.5%, or from about 0.5% to about 4%, or from about 0.5% to about 3%, or from about 1% to about 4.5%, or from about 1% to about 4%, or from about 1% to about 3.5%, or from about 1% to about 3%, or from about 1% to about 2.5%, or from about 1.5% to about 3%, or from about 1.5% to about 2.5%, including all ranges and amounts contained therein.

[0027] In one aspect, the composition as described herein has at least one anti-acne agent. Anti-acne agents as described herein include, but are not limited to, salicylic acid, benzoyl peroxide, sulfur, thymol, willow bark extract, succinic acid, azelaic acid and / or mixtures thereof. In one aspect, the anti-acne agent is salicylic acid, thymol, willow bark extract and / or mixtures thereof. In one aspect, the anti-acne agent is salicylic acid. In one aspect, by weight of the composition as described herein, the amount of the anti-acne agent included is from about 0.001% to about 2%, or from about 0.01% to about 2%, or from about 0.05% to about 2%, or from about 0.05% to about 1.5%, or from 0.05% to about 1.0%, or from about 0.1% to about 2%, or from about 0.5% to about 2%, or from about 0.75% to about 2%, or from about 0.75% to about 1.5%, or from about 0.75% to about 1.25%, including all ranges and amounts included therein.

[0028] In one aspect, the weight ratio of the nonionic surfactant having an HLB of at least 15.7 to the anti-acne agent is from about 5:1 to about 1:1, or from about 4:1 to about 1:1, or from about 3:1 to about 1:1, or from about 2:1 to about 1:2, or from about 2:1 to about 1:1, or about 5:1, or about 3:1, or about 2.5:1, or about 2:1, or about 1.5:1, or about 1:1, including all ratios subsumed therein.

[0029] In one aspect, the pH of the composition as described herein is 3.0 to 7.0, or 3.5 to 6.5, or 3.8 to 6.2, or 4.0 to 6.0, or 4.0 to 5.5, or 4.25 to 5.75, or 4.25 to 5.25. A regulator suitable for changing the pH of the composition as described herein can be used. Such pH regulators include, but are not limited to, triethylamine, NaOH, KOH, H2SO4, HCl, C6H8O7 (i.e., citric acid) and / or mixtures thereof. Buffers (such as potassium oxide) for stabilizing pH are also suitable for use. By using conventional instruments such as from Thermo A commercially available pH meter was used to assess the pH of the composition.

[0030] In one aspect, the composition as described herein comprises at least 88 wt% water, preferably 88 to 94 wt% water; (b) at least 0.5 wt% of a nonionic surfactant having an HLB of at least 15.7, wherein the nonionic surfactant is ceteth-20, laureth-23, polysorbate-20, and / or a mixture thereof; and (c) an anti-acne agent, wherein the anti-acne agent is salicylic acid. Surprisingly and unexpectedly, the composition described herein can be in the form of a stable micellar water (e.g., non-biphasic), wherein the anti-acne agent is not precipitated from the continuous aqueous phase of the micellar water.

[0031] Optional surfactant

[0032] As described herein, it is within the scope of the present invention to include an optional surfactant together with a nonionic surfactant having an HLB of at least 15.7. The optional surfactant can be other nonionic surfactants, such as nonionic surfactants having an HLB of 15.6 or less.

[0033] Other optional surfactants may include those that are amphoteric (which may be zwitterionic, depending on the pH). Exemplary optional amphoteric surfactants suitable for use generally include sodium acylamphoacetate, sodium acylamphopropionate, disodium acylamphodiacetate, and disodium acylamphodipropionate, wherein the acyl group (i.e., alkanoyl) may contain C7-C 18 Alkyl moiety. Illustrative examples of the amphoteric surfactant that can be used include sodium lauroamphoacetate, sodium cocoamphoacetate, sodium lauroamphoacetate, sodium cocoamphoacetate and / or mixtures thereof, and the like.

[0034] With regard to zwitterionic surfactants that may be optionally used in the compositions described herein, such surfactants typically contain at least one acid group. Such acid groups may be carboxylic acid or sulfonic acid groups. They typically include quaternary nitrogen and thus may be quaternary amino acids. They typically should include alkyl or alkenyl groups of 7 to 18 carbon atoms and typically conform to the following general structural formula:

[0035] R 1 --[--C(O)--NH(CH2) q --] r --N + (R 2 )(R 3 )A--B, where R 1 is an alkyl or alkenyl group having 7 to 18 carbon atoms; R 2 and R 3 Each is independently an alkyl, hydroxyalkyl or carboxyalkyl group of 1 to 3 carbon atoms; q is 2 to 4; r is 0 to 1; A is an alkylene group of 1 to 3 carbon atoms, the alkylene group of 1 to 3 carbon atoms is optionally substituted by a hydroxy group, and B is --CO2-- or --SO3--.

[0036] Suitable zwitterionic surfactants for use in the compositions as described herein and within the above general formula include simple betaines of the formula:

[0037] R 1 --N + (R 2 )(R3 )-CH2CO2 -

[0038] and amidobetaines of the formula:

[0039] R 1 --CONH(CH2) t --N + --(R 2 )(R 3 )CH2CO2 - , where t is 2 or 3.

[0040] In both formulas, R 1 , R 2 and R 3 As defined above. 1 C derived from coconut oil 12 Alkyl and C 14 mixture of alkyl groups such that at least half, preferably at least three quarters, of the groups R 1 Has 10 to 14 carbon atoms. 2 and R 3 Preferred is methyl.

[0041] Another possibility is that the zwitterionic surfactant is a sulfobetaine of the formula:

[0042] R 1 --N + (R 2 )(R 3 )-(CH2)3SO3 -

[0043] or

[0044] R 1 --CONH(CH2) u --N + (R 2 )(R 3 )-(CH2)3SO3 -

[0045] Where u is 2 or 3,

[0046] or variations thereof, wherein - (CH2)3SO3 - - CH2C(OH)(H)CH2SO3 - Alternative.

[0047] In these formulas, R 1 , R 2 and R 3 As defined above.

[0048] Illustrative examples of zwitterionic surfactants include betaines, such as cocodimethyl carboxymethyl betaine, cocamidopropyl betaine, and lauroylamidopropyl betaine. Additional zwitterionic surfactants suitable for use include cocamidopropyl sulfobetaine. Such surfactants are commercially available from suppliers such as Stepan Company, and it is within the scope of the present invention to optionally employ mixtures thereof.

[0049] The optional surfactant may also include a cationic surfactant. One class of cationic surfactants includes heterocyclic ammonium salts, such as cetyl or stearyl pyridinium chloride, alkylamidoethyl pyrrylinodium methylsulfate, and lapyrium chloride. Tetraalkylammonium salts are another class of cationic surfactants available. Examples include cetyl or stearyl trimethylammonium chloride or bromide, such as cetyl trimethylammonium chloride; hydrogenated palm or tallow trimethylammonium halide; behenyl trimethylammonium halide or methylsulfate; decyl isononyl dimethylammonium halide; ditallow (or distearyl) dimethylammonium halide, and behenyl dimethylammonium chloride. Other types of cationic surfactants that may be used are various ethoxylated quaternary amines and ester quats. Examples include PEG-5 stearyl ammonium lactate (e.g., Genamin KSL manufactured by Clariant), PEG-2 cocoyl ammonium chloride, PEG-15 hydrogenated tallow ammonium chloride, PEG 15 stearyl ammonium chloride, dipalmitoyl ethyl methyl ammonium chloride, dipalmitoyl hydroxyethyl methyl sulfate, and stearyl amidopropyl dimethylamine lactate. Still other available cationic surfactants include quaternized hydrolyzates of silk protein, wheat protein, and keratin, and it is within the scope of the cleaning composition to use a mixture of the above cationic surfactants. In one aspect, when used, the cationic surfactant is cetrimonium chloride, cetylpyridinium chloride, and / or a mixture thereof.

[0050] The optional surfactant may also include anionic surfactants. Illustrative examples of anionic surfactants include aliphatic sulfonates, such as primary alkanes (e.g., C8-C 22 ) sulfonates, primary alkanes (e.g., C8-C 22 ) disulfonate, C8-C 22 Olefin sulfonates, C8-C 22 Hydroxyalkane sulfonate or alkyl glyceryl ether sulfonate (AGS); or aromatic sulfonate such as alkylbenzene sulfonate. The anionic surfactant may also be an alkyl sulfate (e.g. C 12 -C 18Alkyl sulfates) or alkyl ether sulfates (including alkyl glyceryl ether sulfates). Among the alkyl ether sulfates are those having the following formula:

[0051] RO(CH2CH2O) n SO3M

[0052] wherein R is an alkyl or alkenyl group having 8 to 18 carbons, preferably 12 to 18 carbons, n has an average value of at least 1.0, preferably less than 5, most preferably 1 to 4, and M is a solubilizing cation such as sodium, potassium, ammonium or substituted ammonium.

[0053] The anionic surfactant may also be an alkyl sulfosuccinate (including monoalkyl and dialkyl, such as C6-C 22 sulfosuccinates); alkyl and acyl taurates (usually methyl taurates), alkyl and acyl sarcosinates, sulfoacetates, C8-C 22 Alkyl phosphates and phosphonates, alkyl phosphates and alkoxyalkyl phosphates, acyl lactylates, C8-C 22 Monoalkyl succinates and maleates, sulphoacetates, alkyl glucosides and acyl isethionates and the like.

[0054] The sulfosuccinate salts may be monoalkyl sulfosuccinate salts having the formula:

[0055] R 1 OC(O)CH2CH(SO3M)CO2M;

[0056] and an amide-MEA sulfosuccinate salt of the formula:

[0057] R 1 CONHCH2CH2OC(O)CH2CH(SO3M)CO2M

[0058] Where R 1 In C8-C 22 The range of alkyl groups.

[0059] Sarcosinates are generally represented by the following formula:

[0060] R 2 CON(CH3)CH2CO2M, where R 2 In C8-C 20 The range of alkyl groups.

[0061] Taurates are generally represented by the following formula:

[0062] R 3 CONR 4 CH2CH2SO3M

[0063] Where R 3 For C8-C 20 Alkyl, R 4 It is a C1-C4 alkyl group.

[0064] M is a solubilizing cation as previously described.

[0065] The compositions disclosed herein may contain C8-C 18 Acyl isethionates. These esters are prepared by the reaction of an alkali metal isethionate with mixed aliphatic fatty acids having from 6 to 18 carbon atoms and an iodine value of less than 20. At least 75% of the mixed fatty acids have from 12 to 18 carbon atoms and up to 25% have from 6 to 10 carbon atoms.

[0066] The acyl isethionate may be an alkoxylated isethionate, such as described in U.S. Pat. No. 5,393,466, which is incorporated herein by reference. The compound has the following general formula:

[0067] R 5 C—(O)O—C(X)H—C(Y)H—(OCH2—CH2)m—SO3M

[0068] Among them, R 5 is an alkyl group having 8 to 18 carbons, m is an integer from 1 to 4, X and Y are each independently hydrogen or an alkyl group having 1 to 4 carbons, and M is a solubilizing cation as previously described.

[0069] In one aspect of the composition, the anionic surfactant, if used, is 2-acrylamido-2-methylpropane sulfonic acid, ammonium lauryl sulfate, ammonium perfluorononanoate, potassium lauryl sulfate, sodium alkyl sulfate, sodium lauryl sulfate, sodium laurate, sodium laureth sulfate, sodium lauroyl sarcosinate, sodium stearate, sodium sulfosuccinate, sodium lauroyl isethionate, or a combination thereof. Such anionic surfactants are commercially available from suppliers such as GalaxySurfactants, Clariant, Sino Lion, Stepan Company, and Innospec.

[0070] When present, the amount of the optionally present surfactant included is no more than 4%, or no more than 3%, or no more than 2%, or no more than 1% by weight of the composition described herein. In one aspect, the amount of the optionally present surfactant included is from about 0.001% to about 4%, or from about 0.01% to about 4%, or from about 0.1% to about 2%, or from about 0.1% to about 1%, or from about 0.1% to about 0.75% by weight of the composition described herein, including all ranges and amounts contained therein.

[0071] Emollients

[0072] In one aspect, in the composition disclosed in this article, emollients can be included.These include esters of alkoxylated aromatic alcohols and fatty carboxylic acids, esters of polyglycols or glycols and fatty carboxylic acids such as caprylic / capric triglycerides, esters of fatty alcohols and fatty acids, alkoxylated derivatives of benzyl alcohol, and / or their mixtures.In one aspect, the emollient is caprylic / capric triglycerides, PEG-6 caprylic / capric glycerides, and / or their mixtures.In one aspect, the amount of the emollient (if included) is by the weight of the composition described herein for a total of about 0.001% to about 4%, or about 0.01% to about 4%, or about 0.1% to about 2%, or about 0.1% to about 1%, or about 0.1% to about 0.75%, including all ranges and amounts included therein.

[0073] Moisturizer

[0074] In one aspect, a wetting agent such as a water-soluble polyol may be included in the compositions disclosed herein. These include sorbitol, glycerine (or glycerol), mannitol, xylitol, maltitol, and / or mixtures thereof. Other wetting agents include propylene glycol, dipropylene glycol, polypropylene glycol (such as PPG-9), polyethylene glycol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, propylene glycol, 1,2-octanediol, 1,2-hexanediol, isopentyl glycol, 1,2,6-hexanetriol, ethoxylated glycerine, propoxylated glycerine, and / or mixtures thereof. In one aspect, the wetting agent is glycerine. In one aspect, the wetting agent is a combination of glycerine and hexylene glycol.

[0075] In one aspect, one or more humectants are included in an amount totaling from about 0.1% to about 4.5%, or from about 0.5% to about 4.5%, or from about 1% to about 4.5%, or from about 1% to about 4%, or from about 1% to about 4%, or from about 1.5% to about 3.5%, or from about 2.5% to about 3.5%, by weight of the compositions described herein, including all ranges and amounts subsumed therein.

[0076] In one aspect, the humectant is a combination of hexylene glycol and glycerin in a weight ratio of about 1:5 to about 5:1, or about 1:4 to about 4:1, or about 1:3 to about 3:1, including all ratios subsumed therein. In one aspect, the weight ratio of hexylene glycol to glycerin is about 5:1, or about 3:1, or about 2.5:1.

[0077] preservative

[0078] In one aspect, preservatives may be included in compositions disclosed herein. About the exemplary preservatives suitable for use, these include sodium benzoate, iodopropynyl butylcarbamate, phenoxyethanol, hydroxyacetophenone, ethylhexylglycerol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, dimethyl-dimethyl (DMDM) hydantoin, benzyl alcohol, and / or their combination. Other preservatives suitable for use include sodium dehydroacetate, chlorophenesin and decanediol. By the weight of the composition described herein, the amount of one or more preservatives included is about 0.01% to 2.0% or about 0.1% to about 1% or about 0.1% to about 0.75% in total, including all ranges included therein.

[0079] Optional additives

[0080] In the composition as disclosed herein, fragrance, fixative, sunscreen (such as titanium dioxide), chelating agent (such as EDTA) can be optionally included. According to the weight of the composition described herein, the amount of optional fragrance, fixative, sunscreen and chelating agent included is about 0.03% to 3%, or about 0.1% to 2.6%, including all ranges contained therein.

[0081] Another optional additive suitable for use includes hemp oil having 2.5 to 25% by weight of cannabidiol and / or 0.5 to 10% by weight of cannabidiol. When optionally used, such oils comprise 0.0001 to 1.5% by weight of the composition, preferably 0.01 to 1% by weight of the composition, including all ranges and amounts contained therein.

[0082] Film formers can be used in the compositions of the present invention. Although optional, such agents can help adhere the compositions to the surfaces to which they are applied. Film formers include those with hydrophilic properties, and they include materials including polyvinyl pyrrolidone (PVP), acrylates, acrylamides, and their copolymers. Deposition agents such as organosiloxanes can also be used. When optionally used, such agents account for 0.001% to 1% by weight of the composition, including all ranges and amounts contained therein.

[0083] In one aspect, the compositions as disclosed herein are substantially free of thickeners or gelling agents, such as silicon dioxide, sodium carboxymethylcellulose and / or carbomer. In another aspect, the compositions as disclosed herein are substantially free of parabens, silicones and / or sulfates. "Substantially free" as used herein means less than 0.5% by weight of the composition, or less than 0.1% by weight of the composition, preferably 0% by weight of the composition.

[0084] Optional Skin Benefit Agents

[0085] Optional skin benefit agents that may be provided in the compositions herein include water-soluble moisturizers, occlusive agents, plant extracts, vitamins and minerals, resorcinols, optical agents, uniform toning agents, anti-inflammatory agents, light stabilizers, antioxidants, wrinkle reducing agents, desquamation promoting agents, and / or mixtures thereof, etc. Each of these materials may be present in an amount of about 0.05% to about 5%, or about 0.1% to about 4%, or about 0.1% to about 2% by weight of the composition, including all ranges and amounts contained therein.

[0086] Water-soluble moisturizers are suitable for the optional skin benefit agents. These include dicaprylyl carbonate and substituted ureas such as hydroxymethyl urea, hydroxyethyl urea, hydroxypropyl urea; di(hydroxymethyl)urea; di(hydroxyethyl)urea; di(hydroxypropyl)urea; N,N'-dimethylol urea; N,N'-di-hydroxyethyl urea; N,N'-di-hydroxypropyl urea; N,N,N'-tri-hydroxyethyl urea; tetra(hydroxymethyl)urea; tetra(hydroxyethyl)urea; tetra(hydroxypropyl)urea; N-methyl, N'-hydroxyethyl urea; N-ethyl-N'-hydroxyethyl urea; N-hydroxypropyl-N'-hydroxyethyl urea and N,N'dimethyl-N-hydroxyethyl urea; and / or mixtures thereof. Where the term "hydroxypropyl" occurs, the meaning is common to 3-hydroxy-n-propyl, 2-hydroxy-n-propyl, 3-hydroxy-isopropyl or 2-hydroxy-isopropyl. For optional use, hydroxyethyl urea is most preferred. It is available from Nouryon as a 50% aqueous liquid under the trademark Available.

[0087] Vitamins are suitable for use as optional skin benefit agents. Vitamins such as vitamin A (including retinoic acid precursors), vitamin B2, pyridine amide, niacinamide (vitamin B3), panthenol (vitamin B5), vitamin B6, vitamin C (also including ascorbyl tetraisopalmitate, magnesium ascorbyl phosphate and ascorbyl glucoside), vitamin D, vitamin E, vitamin K, and / or mixtures or derivatives thereof, etc., can be used. The retinoic acid precursor can be retinol, retinal, retinyl propionate, retinyl palmitate, retinyl acetate, and / or mixtures thereof. Yet another retinoic acid precursor suitable for use is provided by Molecular Design International under the name The commercially available hydroxyanasatil retinoate.

[0088] Other optional skin benefit agents suitable for use include resorcinols, such as 4-hexylresorcinol, 4-ethylresorcinol, 4-phenylethylresorcinol, 4-cyclopentylresorcinol, 4-cyclohexylresorcinol, 4-isopropylresorcinol, isobutylamidothiazolylresorcinol (e.g., Thiamidol), and / or mixtures thereof. Moreover, 5-substituted resorcinols, such as 4-cyclohexyl-5-methylbenzene-1,3-diol, 4-isopropyl-5-methylbenzene-1,3-diol, mixtures thereof, and the like, may be used. The 5-substituted resorcinols and their synthesis are described in commonly assigned U.S. Patent Application Publication No. 2016 / 0000669A1.

[0089] Other suitable optional skin benefit agents include omega-3 fatty acids; omega-6 fatty acids; climbazole; magnolol; honokiol; farnesol; ursolic acid; myristic acid; geranylgeraniol; oleyl betaine; cocoyl hydroxyethyl imidazoline; caproyl sphingosine; 12-hydroxystearic acid; conjugated linoleic acid; stearic acid; palmitic acid; lauric acid; hyaluronic acid and its salts (such as Na+ and K+ salts of hyaluronic acid); ceramides (e.g., ceramide 1, ceramide 3, ceramide 3B and ceramide 6) and pseudoceramides; allantoin; pyroglutamic acid (PCA) salt derivatives including PCA zinc and PCA sodium; petroselinic acid (petrosol); acid); terpineol; limonene; pinene; camphene; cymene; citronellol; citronellal; geraniol; nerol; linalool; rhodiolaol; borneol; isoborneol; menthone; camphor; safrole; isosafrole; eugenol; isoeugenol; tea tree oil; eucalyptus oil; peppermint oil; neem oil; lemongrass oil; orange oil; bergamot oil; and extracts such as sage, aloe vera, green tea, sugar cane, citrus, grape seed, thyme, chamomile, yarrow, cucumber, licorice, rosemary extract; and / or mixtures thereof, etc.

[0090] Composition as described herein can be in the form of disposable (leave-on) composition.About packaging, composition as described herein can be packaged in spray bottle, bottle with self-foaming mechanism / pump, or be provided on cotton swab, wet tissue, towelette, cosmetic matrix sheet (such as those described in No. 6,294,182 United States Patent) etc. as impregnated wetting agent.The spray bottle can also be metallic, and the composition can be provided via conventional aerosol packaging technology, and include utilizing those of air discharge tank, mechanism and transmission device in bag.Comprising foaming agent (such as zwitterionic surfactant and / or amphoteric surfactant) also within the scope of the present invention, so that the composition can be discharged as foam.In one embodiment of the invention, the composition is provided in a standard spray bottle with a spray transmission device, and is sprayed on the surface, particularly on the skin.

[0091] As used herein, "precursor" refers to the following composition, which is a concentrate and is suitable for dilution (or hydration) with water to prepare a ready-to-use composition. When preparing the precursor of the composition described herein, the ingredients are mixed with moderate shear under atmospheric conditions and at a temperature of 20 to 65° C. According to the required volume, the precursor (with less than 15% by weight of water) should be mixed with water, followed by moderate stirring to prepare the required disinfecting composition. The precursor can be provided in a biodegradable package, and the packaging used can be refillable or reusable, biodegradable, and / or at least 50%, or at least 100%, made of post-consumer recycled resin.

[0092] In another aspect, is a method for reducing, treating, controlling and / or preventing the occurrence of acne, the method comprising: (a) applying a composition to the surface of the skin, the composition comprising (i) 88% to 94% by weight of water; (ii) at least 0.5% by weight of a nonionic surfactant having an HLB of at least 15.7; and (iii) an anti-acne agent; and (b) optionally, rubbing the composition into the surface of the skin. Optionally, the method can be repeated daily, or twice a day or three times a day.

[0093] The method of reducing, treating, controlling and / or preventing the occurrence of acne may not require specialized equipment and may be determined by visually assessing, for example, differences in the number or size of acne lesions, particularly after a specific period of time, such as at least one week, at least two weeks, at least three weeks, or at least one month, or may be determined by assessing the visual texture, color and / or appearance of the skin, particularly after a specific period of time, such as at least one week, at least two weeks, at least three weeks, or at least one month.

[0094] In another aspect, is a method for providing an anti-acne benefit to the skin after applying a composition to a skin surface in need thereof, wherein the composition applied to the surface of the skin comprises (i) 88% to 94% by weight of water; (ii) at least 0.5% by weight of a nonionic surfactant having an HLB of at least 15.7; and (iii) an anti-acne agent; and (b) optionally rubbing the composition into the surface of the skin. Optionally, the method can be repeated daily, or twice daily or three times daily.

[0095] The composition of the present invention should be provided with instructions for applying or spraying the composition onto a surface (e.g., skin). Optionally, after applying the composition, the user may be instructed to rub the composition into the surface. Further optionally, the user may be instructed to apply the composition daily, or to repeat twice a day or three times a day.

[0096] The following examples are provided to further illustrate the understanding of the present invention. These examples are not intended to limit the scope of the claims.

[0097] Example

[0098] Example 1

[0099] For each composition, water was heated to 80°C with mixing. At 80°C, EDTA, citric acid, and salicylic acid were added and mixed for about 10 minutes or until all particles were dissolved. Then, sodium hydroxide was added and mixed, followed by the slow addition of a nonionic surfactant. Then, while the solution was cooled to 36°C, hexylene glycol and glycerin were added, followed by an emollient, and further followed by a cationic surfactant, a preservative, and niacinamide. Each composition was observed after being stored overnight at room temperature.

[0100]

[0101] As shown above, surprisingly and unexpectedly, only the composition containing 88 wt% to 94 wt% water, a nonionic surfactant having an HLB of at least 15.7, and an anti-acne agent remained clear, transparent and stable, and free of precipitate. The composition lacking a nonionic surfactant having an HLB of at least 15.7 was unstable and separated into two phases (e.g., biphasic).

Claims

1. A composition comprising: a) 88 to 94% by weight of water; b) 1 to 3 wt% of a nonionic surfactant having an HLB of 15.7 to 18; and c) an anti-acne agent, wherein the anti-acne agent is salicylic acid.

2. The composition according to claim 1, wherein the HLB of the nonionic surfactant is from 15.7 to 17.5, more preferably from 15.7 to 16.

9.

3. The composition according to claim 1 or 2, wherein the nonionic surfactant is ceteth-20, laureth-23, polysorbate-20 and / or a mixture thereof, preferably polysorbate-20.

4. A composition according to any preceding claim, wherein the composition comprises from 1.5% to 2.5% of the non-ionic surfactant.

5. A composition according to any one of the preceding claims, wherein the composition comprises 0.001 wt% to 2 wt%, or 0.05 wt% to 1.0 wt%, or 0.5 wt% to wt%, or 0.75 wt% to 1.5 wt%, or 0.75 wt% to 1.25 wt% of the anti-acne agent.

6. A composition according to any one of the preceding claims, wherein the composition is substantially free of thickeners, gelling agents, parabens, silicones and / or sulfates.

7. A composition according to any one of the preceding claims, wherein the weight ratio of the nonionic surfactant to the anti-acne agent is 5:1, or 3:1, or 1.5:

1.

8. A composition according to any one of the preceding claims, wherein the composition comprises 88% to 93% by weight, or 90% to 93% by weight, water.

9. A composition according to any one of the preceding claims, wherein the composition is a stable micellar water, preferably transparent.

10. A composition according to any one of the preceding claims, further comprising at least one optional surfactant, preferably a cationic surfactant.

11. The composition according to any one of the preceding claims, further comprising a polyol, and the polyol is sorbitol, glycerol, mannitol, xylitol, maltitol, dipropylene glycol, polypropylene glycol, polyethylene glycol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2-octanediol, 1,2-hexanediol, isopentyl glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and / or mixtures thereof, preferably glycerol, hexylene glycol and / or mixtures thereof.

12. A composition according to any one of the preceding claims, further comprising at least one optional skin benefit agent, and wherein the optional skin benefit agent is a water-soluble moisturizer, an occlusive agent, a plant extract, a vitamin and mineral, a resorcinol, an optical agent, a toning agent, an anti-inflammatory agent, a sunscreen and light stabilizer, an antioxidant, a wrinkle reducing agent, a desquamation promoting agent, and / or mixtures thereof.

13. A composition according to any preceding claim, further comprising at least one of a fragrance, an immobilizing agent, a sunscreen, a chelating agent, and / or an emollient.

14. Non-therapeutic use of a composition according to any one of claims 1 to 10 as an anti-acne composition or for obtaining anti-acne benefits.

15. A non-therapeutic method for reducing, treating or preventing the occurrence of acne, the method comprising: a. applying a composition to the surface of the skin, the composition comprising (i) 88% to 94% by weight of water; (ii) 1 wt% to 3 wt% of a nonionic surfactant having an HLB of 15.7 to 18; and (iii) an anti-acne agent; b. Optionally, applying the composition to the surface of the skin; and c. Optionally, repeat step (a) and optional step (b) daily, or twice daily, or three times daily.

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