Oxygen supply device with fiO2 control

Abstract

An oxygen supply device includes an oxygen generating unit (204), a control unit (202), a blower (706), and a gas conditioning unit (206). The oxygen generating unit (204) comprises a plurality of adsorption units (404), and the plurality of adsorption units (404) comprise a first adsorption unit (404a) and a second adsorption unit (404b); the blower (706) is configured to receive ambient air and oxygen generated by the oxygen generating unit (204) and output mixed air at a desired FiO2 ratio. The gas conditioning unit (206) is connected to the blower (706) and is configured to generate conditioned air using the mixed air from the blower (706). The control unit (202) is configured to: control the first adsorption unit (404a) and the second adsorption unit (404b) to operate independently of each other such that the first adsorption unit (404a) and the second adsorption unit (404b) operate alternately; and independently controls the flow rate of oxygen generated by the oxygen generating unit (204) and the flow rate of ambient air entering the blower (706).

Description

[0001] This application claims priority to U.S. patent application US17 / 744,618, entitled “OXYGEN SUPPLY DEVICE WITH FIO2 CONTROL,” filed on May 13, 2022, which is incorporated herein by reference in its entirety. Technical Field

[0002] The present disclosure relates to oxygen supply devices designed and configured for non-professional use environments, such as in a patient's home. Background Art

[0003] Medical ventilators are used to help the lungs work. Basically, medical ventilators help patients get oxygen into their lungs and get carbon dioxide out of their bodies. One of the most widely used ventilators is the high flow nasal canula (HFNC). High flow nasal cannula (HFNC) is an oxygen delivery device that provides oxygen therapy to patients with respiratory dysfunction and is recommended by the World Health Organization (WHO) and the National Institutes of Health (NIH) as the preferred device for treating COVID-19 patients. The SARS-CoV-2 virus causes COVID-19, which is highly contagious. Performing HFNC procedures on COVID-19 patients poses a huge risk to healthcare workers. In Los Angeles hospitals alone, more than 38,000 healthcare workers have been infected by SARS-CoV-2.

[0004] HFNC machines help patients with limited and impaired respiratory capacity. Typically, HFNC machines deliver a flow of heated and humidified oxygen-enriched air to the patient through a nasal cannula. The flow rate of oxygen-enriched air by HFNC machines is usually higher than the normal inspired air flow rate of healthy people in the same age group. Clinical results have shown that HFNC helps patients with a variety of indications, including hypoxemic respiratory failure due to pneumonia, post-extubation, pre-intubation preoxygenation, acute pulmonary edema, etc.

[0005] An oxygen supply unit is a device that supplies an oxygen-enriched product gas stream. An oxygen supply unit may be used in a healthcare setting to supply oxygen to patients for the treatment of respiratory-related conditions such as asthma, pneumonia, respiratory distress syndrome, bronchopulmonary dysplasia, and chronic obstructive pulmonary disease. Summary of the invention

[0006] According to the present invention, an integrated oxygen supply device is provided. In some embodiments, the oxygen supply device according to the present invention includes an oxygen generation unit, a gas regulating unit, a gas delivery unit, a control unit and / or any other components. In those embodiments, the oxygen generation unit is configured to receive ambient air and produce concentrated oxygen. In one embodiment, the oxygen generation unit includes an oxygen concentration module, which is configured to receive pressure-regulated air and produce concentrated oxygen. In this embodiment, the oxygen concentration module includes one or more adsorption units, which are configured to produce concentrated oxygen by absorbing oxygen from pressure-regulated air and releasing nitrogen in the pressure-regulated air. In one example, the oxygen concentration module includes a plurality of adsorption units so that they can be configured to operate in parallel or alternately.

[0007] In some embodiments, the control unit is configured to control the oxygen concentration module to set one or more adsorption units to an operating state or a closed state. In the operating state, the adsorption unit is configured to separate oxygen and nitrogen in the pressure-regulated air; and in the closed state, the adsorption unit is configured to release concentrated oxygen to the oxygen storage module of the oxygen concentration module and release nitrogen to the environment around the oxygen supply device according to the present disclosure.

[0008] Other objects and advantages of the present invention will be apparent to those skilled in the art based on the following drawings and detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 An integrated oxygen supply device according to the invention is generally shown.

[0010] Figure 2 Shows Figure 1 An example of an oxygen supply arrangement is shown.

[0011] Figure 3 Shows Figure 2 An example of an oxygen generating unit is shown.

[0012] Figure 4 Shows Figure 3 An example of an oxygen concentrator module is shown.

[0013] Figure 5 Shows Figure 2 Another example of an oxygen generating unit is shown.

[0014] Figure 6 The method for controlling the Figure 4 An example of a method of an oxygen concentrator module is shown.

[0015] Figure 7 Shows Figure 2An example of a gas conditioning unit is shown.

[0016] Figure 8 Another exemplary embodiment of an integrated oxygen supply according to the present disclosure is shown.

[0017] Fig. 9 Yet another exemplary embodiment of an integrated oxygen supply according to the present disclosure is shown.

[0018] Fig.10 An exemplary computer system is shown that can be used to implement the various embodiments described and illustrated herein. DETAILED DESCRIPTION

[0019] The following disclosure provides many different embodiments or examples for implementing different features of the provided subject matter. Specific examples of components and arrangements are described below to simplify the present disclosure. Of course, these are merely examples and are not intended to be limiting. For example, in the following description, forming a first feature on or above a second feature may include an embodiment in which the first and second features are directly contacted and formed, and may also include an embodiment in which additional features may be formed between the first and second features, so that the first and second features may not be in direct contact. In addition, the present disclosure may repeat reference numerals and / or letters in various examples. This repetition is for the purpose of simplicity and clarity and does not itself specify the relationship between the various embodiments and / or configurations discussed. For specific repeated reference numerals, the structures and / or functions described and illustrated herein may be cross-referenced.

[0020] Patients with moderate to severe COVID-19 often have pneumonia that may lead to hypoxemia. The World Health Organization (WHO) and the National Institutes of Health (NIH) recommend the use of high-flow nasal cannula (HFNC) to supplement oxygen for COVID-19 patients with hypoxemia. HFNC can deliver 10-80L / min of humidified and body-temperature oxygen to meet the patient's needs, reducing patient discomfort and respiratory workload. It also improves ventilation and oxygenation by flushing the nasopharyngeal dead space. HFNC has been shown to reduce 90-day mortality and intubation rates in patients with acute hypoxemic respiratory failure compared with conventional oxygen therapy or noninvasive positive pressure ventilation (NIPPV).

[0021] As the patient's condition changes over time; the HFNC settings need to be adjusted accordingly. Due to the nature of the high airflow, both the WHO and NIH classify HFNC as an aerosol-generating procedure, which when used on COVID-19 patients is defined as a high-risk exposure for Health Care Workers (HCWs); it becomes a critical frontline to ensure the safety of HCWs. Studies have shown that frontline HCWs are at least 3 times more likely to be infected. When our Personal Protective Equipment (PPE) is in limited supply, HCWs are at greater risk. Compared with HCWs who have not been exposed to COVID-19 patients, HCWs who have been exposed to COVID-19 patients but have insufficient or reused PPE have a 5-6 times higher infection rate in Los Angeles County, the most populous county in the United States. As of March 2021, more than 38,000 HCWs and first responders have been confirmed to be infected with the COVID-19 virus. The COVID-19 pandemic is a huge challenge for our entire society, but hospitals and our frontline HCWs have been under unprecedented pressure due to the huge number of COVID patients and the high infectiousness of COVID-19. During the COVID-19 pandemic, different waves of infection occurred at different times in different countries. Therefore, if HFNC treatment can be provided at home, some or all of the above risks may be reduced or avoided.

[0022] One problem with current oxygen delivery is that it is not suitable for home use to achieve effective HFNC therapy. The reason why HFNC therapy is currently unacceptable for patients at home is that an excessive amount of oxygen supply is required to effectively treat the patient. In some cases, effective HFNC therapy may require a flow rate of 40 liters per minute (LPM) and a fraction of inspiration O2 (FiO2) of 40%. High-pressure oxygen sources (such as compressed gas cylinders) or fixed medical oxygen pipeline systems (such as oxygen tanks) are conventional means of providing this level of enriched oxygen to patients. However, oxygen tanks are expensive, difficult to handle, and difficult to move, and therefore are generally not suitable for home use.

[0023] As mentioned above, for effective HFNC treatment, an oxygen supply with a flow rate of 40 LPM or more at 40 FIO2 (40 / 40) is ideal. This means that the oxygen source is able to provide 11 LPM at 90% FiO2. Since the air separation material used in the oxygen generation unit will decay, the separation efficiency will drop from 90% to 80%, so a 13 LPM oxygen generation unit is best to always meet the 40 / 40 requirement. Taking into account the decay of the material, a 13 LPM, 90% FiO2 oxygen generation unit is required. (Note: Taking into account the decay of the material, according to calculations, at a flow rate of 50 lpm (40 / 50), 40% FiO2 may require 16 lpm of 90% oxygen source). Concentrated oxygen is required to facilitate this treatment. However, due to size and / or cost limitations, existing portable oxygen generation devices are generally only able to produce about 2-5 LPM of oxygen from ambient air. Although some portable oxygen concentrators are available on the market that produce about 10 LPM of oxygen, they still do not meet the 13 LPM required for the above-mentioned 40 / 40 oxygen supply. Furthermore, existing technologies are expensive, bulky, and power-hungry for home use. Therefore, a challenge in implementing effective HFNC therapy in a non-professional setting (e.g., in a patient's home) is how to generate and deliver oxygen, e.g., 40 LPM / 40 FIO2, using an oxygen supply that is reasonably sized and affordable.

[0024] One viewpoint provided by the present disclosure is an integrated oxygen supply device, which includes an oxygen generation unit, a gas regulating unit, a gas delivery unit, a control unit and / or any other components. It should be understood that the integrated oxygen supply device according to the present disclosure is a single device having a housing, and the oxygen generation unit, the gas regulating unit, the gas delivery unit and the control unit are located within the housing. Some considerations for the integrated oxygen supply device according to the present disclosure include form factor, cost (affordability), power consumption, efficiency, effectiveness and / or any other considerations. As described above, in order to achieve a relatively small form factor of the integrated oxygen supply device according to the present disclosure, a small or reasonably sized oxygen source is required, such as an air separation unit capable of producing 13 LPM oxygen.

[0025] With this oxygen source in an integrated oxygen supply, measures or design choices will be taken to bridge the above-mentioned LPM gap to achieve effective treatment. One insight provided by the present disclosure is that the flow rate of oxygen output from the air separation unit in the integrated oxygen supply can be controlled. The inventors have also explored other considerations to reduce or eliminate this LPM gap. Recognition of other considerations ultimately led to other disclosures to enable HFNC treatment to be performed in a non-professional environment (such as a patient's home).

[0026] In U.S. Patent No. 11135390, insights are provided for controlling an oxygen supply device based on patient measurement data. Among other things, the purpose of such control is to accurately determine the volume of high-concentration oxygen required by the patient and dynamically adjust the volume based on the determination to achieve a therapeutic effect. U.S. Patent No. 11135390 is incorporated herein by reference in its entirety.

[0027] According to the present disclosure, in some embodiments, the oxygen generation unit includes a compressor, a cooling module, a pressure regulator, an oxygen concentration module, an oxygen storage module and / or any other components. An insight provided by the present disclosure is that the oxygen concentration module may include a plurality of adsorption units that can be controlled to work in parallel or alternately. In such a design, the oxygen generation efficiency is improved. For example, in one embodiment, the oxygen concentration module includes two controllable adsorption units that work alternately, so that when one of the adsorption units works to separate oxygen and nitrogen in the received air, the other adsorption unit is set to a closed state to release the adsorbed nitrogen into the environment. In this example, when the currently working adsorption unit is saturated with nitrogen, it is controlled to switch to a closed state to release nitrogen into the environment, and the other adsorption unit is set to a working state to separate oxygen and nitrogen in the received air. In this example, the timing of such control of the adsorption unit is controlled by the control unit. In this example, one or more sensors are arranged at and / or around the oxygen concentration module to monitor the concentration level of oxygen produced by the working adsorption unit. Based on the monitored concentration level, the control unit may determine whether to switch the working adsorption unit to the off state, and switch the off adsorption unit to the working state.

[0028] In order to achieve one or more of the above advantages, an integrated oxygen supply device is provided according to the present disclosure, which is configured to continuously generate oxygen and discontinuously release oxygen. In those embodiments, the delivery of oxygen generated by the integrated oxygen supply device to the patient is controlled. In some embodiments, the delivery of oxygen is controlled according to one or more breathing patterns. The breathing pattern may or may not be the patient's current breathing pattern. For example, in one embodiment, the breathing pattern is a predetermined breathing pattern having a specified inhalation period followed by a specified exhalation period. In this embodiment, the specification of the inhalation and exhalation periods in the predetermined breathing pattern is configured to facilitate providing 40 LPM of oxygen to the user for HFNC treatment.

[0029] Figure 1 An integrated oxygen supply device according to the invention is generally shown. Figure 1The integrated oxygen supply device 100 in can use ambient air as an input gas and supply regulated gas to the patient 102 for treatment. Examples of regulated gas can include pressurized, high-flow, heated and / or humidified gas with a certain oxygen concentration level. As described above, Figure 1 An advantage of the illustrated integrated oxygen supply device 100 is that it is a single integrated device that can produce regulated gas to the patient 102 and can be used in a non-professional environment, such as the patient's 102 home due to its form factor and the affordability of such use.

[0030] Figure 2 Shows Figure 1 1. An example of an integrated oxygen supply device as shown. As shown, in this example, the integrated oxygen supply device 100 includes a control unit 202, an oxygen generation unit 204, a gas regulation unit 206, a gas delivery unit 208, and / or any other components. The control unit 202 is configured to control various operations of the integrated oxygen supply device 100. Specifically, the control unit 202 is configured to control one or more operating aspects of the oxygen generation unit 204, one or more conditions of the regulated gas generated by the gas regulation unit 206, one or more operations of the gas regulation unit 206, the timing of the gas regulation unit 206 delivering oxygen to the patient 102, and / or any other aspects of the integrated oxygen supply device 100.

[0031] As will be appreciated by those skilled in the art, the control unit 202 may be physically implemented using a software controlled microprocessor, hardwired logic circuitry, or a combination thereof. For example, the control unit 202 may be implemented as a microprocessor configured to execute one or more software algorithms in conjunction with a memory (not shown) including the timing control, gas mixing control, gas conditioning processes of the various embodiments described herein to provide the various functions of the integrated oxygen supply 100. That is, the control unit 202 may include a non-volatile memory for storing executable software code that allows the control unit 202 to perform the various functions and various processes of the integrated oxygen supply 100 discussed herein.

[0032] The oxygen generation unit 204 is configured to receive ambient air, separate oxygen and nitrogen in the received ambient air to generate concentrated oxygen, and output the concentrated oxygen to the gas conditioning unit 206. In various embodiments, the oxygen generation unit 204 is controllable to store oxygen and output the concentrated oxygen at a desired time or frequency. In those embodiments, the oxygen generation unit 204 is capable of outputting concentrated oxygen with an oxygen concentration in a range between 40%-98%.

[0033] The gas conditioning unit 206 is configured to receive the concentrated oxygen and ambient air output by the oxygen generation unit 204 and output conditioned gas using the received concentrated oxygen and ambient air. In various embodiments, the conditioned gas output by the gas conditioning unit 206 is conditioned by heating, humidification, pressurization, and / or any other conditioning process.

[0034] The gas delivery unit 208 is configured to receive the regulated gas and facilitate delivery of the received mixed gas to the patient 102. In various embodiments, the gas delivery unit 208 is configured to facilitate delivery of the received regulated gas according to a pulsation pattern such that the mixed gas is delivered to the patient with controlled timing. It should be understood that the method employed by the gas delivery unit 208, without limitation to methods of delivering gas to the patient 102 based on the inhalation and exhalation rhythm of the patient 102, may include a pulsation pattern predetermined for the patient 102. This may help the patient 102 adjust or adapt to the level desired by the patient 102. Additionally, this may help increase the LPM of oxygen delivered to the patient 102 because the mixed gas is not continuously released to the patient 102.

[0035] Having generally described the integrated oxygen supply device 100 according to the present disclosure, attention will now be turned to Figure 3 , which shows an example 300 of the oxygen generation unit 204. It can be seen that in this example, the example 300 of the oxygen generation unit 204 includes a compressor 302, a cooling module 304, a pressure regulator 306, an oxygen concentration module 308, an oxygen storage module 310 and / or any other components.

[0036] In this example, as shown in the figure, the compressor is configured to receive ambient air, compresses ambient air to achieve desired pressure and / or flow, thereby obtains compressed air. In implementation, pressure sensor and flow sensor can be applied in compressor 302, to detect whether the pressure and flow rate of compressed air have reached the desired level. Feedback control mechanism can be applied in compressor 302, to ensure the desired pressure and flow rate. In certain embodiments, control unit 202 is configured to control one or more operation aspects of compressor 302. For example, control unit 202 can be configured to control compressor 302 so that ambient air is compressed to preset pressure and / or flow rate. In an example, compressor 302 is controlled by control unit 202, so that air is compressed to 50 pounds per square inch (PSI).

[0037] In this example, the cooling module 304 is used to cool the compressed air output by the compressor 302 to achieve a desired temperature level for the air. In various embodiments, the cooling module 304 includes a cooling coil configured to continuously cool the compressed air through heat exchange. In these embodiments, the heat exchange process facilitated by the cooling module 304 is controlled by the control unit 202. For example, the control unit 202 is configured to control the desired temperature level. In this case, a temperature sensor is used to provide a feedback mechanism so that the control unit 202 monitors the temperature reading of the air to determine whether the desired temperature level has been reached. (Have we disclosed a heat exchange implementation? For example, the heat released from 304 can be used to increase the temperature of the humidification unit. This is a unique advantage of the integrated solution of the device. Other heat sources can be 302, 502, etc.). By utilizing the heat from the oxygen generation unit, we can also claim to be able to reduce the size of the heater and the power consumption of the humidification unit in the implementation to reduce the overall size and power of the device. It would be nice if we could semi-quantify this. )

[0038] Pressure regulator 306 is configured to regulate the pressure and / or flow rate of compressed air input to oxygen concentrator module 308. In some embodiments, pressure regulator 306 is used to regulate the pressure of compressed air at a more or less consistent pressure level (e.g., 50 PSI or 45 PSI) and a consistent flow rate level (e.g., 90 liters per minute (LPM)). For example, pressure regulator 306 can be configured to ensure that the compressed air supplied to oxygen concentrator module 308 is regulated at 50 PSI. This can ensure efficient operation of oxygen concentrator module 308 to produce concentrated oxygen from compressed air by absorbing nitrogen.

[0039] The oxygen concentration module 308 is configured to produce concentrated oxygen from compressed air and release nitrogen from the compressed air. In implementation, the oxygen concentration module 308 includes one or more adsorption units configured to separate oxygen from nitrogen in the compressed air received by the oxygen concentration module 308. In this embodiment, the adsorption unit includes a porous material such as a zeolite, a MOF structure, a COF structure and / or any other type of porous material. The porous material in these embodiments is used to absorb nitrogen from the compressed air, thereby separating oxygen from nitrogen in the compressed air. In one embodiment, when the compressed air flows through the porous material in the oxygen concentration module 308, the nitrogen content in the compressed air is absorbed. In this embodiment, because the nitrogen content in the compressed air is absorbed and released through the N2 exhaust port device shown, oxygen-enriched air or concentrated oxygen is produced. In implementation, the release of the adsorbed nitrogen can be controlled. For example, when the porous material reaches a predetermined saturation level, the adsorbed nitrogen is released. In implementation, the release of the adsorbed nitrogen can be controlled by changing the pressure and / or temperature of the porous material.

[0040] Figure 4 An example 400 of an oxygen concentration module 308 according to the present disclosure is shown. It can be seen that the example 400 of the oxygen concentration module 308 includes a plurality of adsorption units 404, which can be controlled to operate in parallel and / or alternately. In this example, a given adsorption unit 404 is connected to a corresponding switching valve 402. For example, adsorption unit 404a is connected to switching valve 402a, adsorption unit 404b is connected to switching valve 402b, and adsorption unit 404n is connected to switching valve 404n, as shown.

[0041] Attention is now directed to the switching valve 402a for describing the operating state of the adsorption unit #1 in this embodiment. As shown, the switching valve 402a is in a first state, wherein the circuit 4022a is closed to a first position to facilitate the flow of pressure-regulated air from the pressure regulator 306 to the adsorption unit #1 404a. In the first state, the switching valve 402a also has a position to close the nitrogen vent. Therefore, in the first state, the switching valve 402a allows the pressure-regulated air to enter the adsorption unit #1 404a to produce concentrated oxygen.

[0042] In some embodiments, the switching valve 402a is controlled by the control unit to periodically switch to the first state (e.g., the first loop 4022a is closed and the N2 exhaust port is closed). In one embodiment, the switching valve 402a is controlled to switch to the first state every 10 seconds to stay in the first state for 5 seconds. For example, at the 0th second, the switching valve 402a is controlled to switch to the first state and remain for 5 seconds, at the 5th second, the switching valve 402a is controlled to switch to the second state and remain for 5 seconds, and at the 10th second, the switching valve 402a is controlled to switch to the first state; and so on.

[0043] Now focus on the switching valve 402n, where the switching valve 402n is set to the second state. In the second state, the first loop 4022b is in the second position, so that the N2 exhaust port is open to facilitate the release of nitrogen from the adsorption unit #2 404n, and the path of the pressure-regulated air to the adsorption unit #n 404n is open, so that the pressure-regulated air cannot flow into the adsorption unit #n 404n.

[0044] In the first state, adsorption unit #1 404a absorbs nitrogen from the incoming air at, for example, about 50 PSI. As described above, adsorption unit #1 404a can be set to the first state for a period of time, such as 5 seconds. During this period, concentrated oxygen is produced and released to the oxygen storage module 310 for storage. In the second state, adsorption unit #n 404n releases the adsorbed nitrogen to the environment through the N2 exhaust port for a period of time (such as 5 seconds). Then, at the 5th second, adsorption unit #1 404a is set to the second state, and adsorption unit #n 404n is set to the first state. In this way, adsorption unit #1 404a is set to the second state.

[0045] 404a and adsorption unit #n 404n are operated alternately to improve oxygen production efficiency.

[0046] In some embodiments, the control unit 202 coordinates the various adsorption units to work in parallel and / or alternately to achieve one or more oxygen production targets. In one embodiment, a given adsorption unit (e.g., adsorption unit #1 404a) includes a pair of sieve beds. However, this should not be construed as limiting. It is contemplated that the adsorption units in an integrated oxygen supply according to the present disclosure may include any number of sieve beds from 1 to any number. However, it should also be understood that a typical adsorption unit in a PSA system includes a pair of sieve beds for generating oxygen in an efficient manner.

[0047] According to the present disclosure, the individual adsorption beds can be controlled by, for example, the control unit 202 to be turned on / off independently of each other at any given time. As described above, for example, turning on adsorption unit #1 404a can turn on a pair of sieve beds therein. Therefore, in this embodiment, at a given time, an even number of sieve beds in the adsorption unit can be turned on to produce oxygen. (So each unit, such as 404a, has two sub-units or two sieve beds? If this is the concept, we should clarify it in the text.) (Why an "even" number of sieve beds?)

[0048] One insight provided by the present disclosure is that the amount of oxygen to be generated and supplied to the patient 102 can be determined to control the amount of sieve beds to be turned on in the adsorption unit. The following table shows the working conditions of two adsorption units in the integrated oxygen supply device according to the present disclosure using Formula 1: (QO2, Qtotal and FiO2 need to be defined in the formula and the following table. Is FiO2 the desired FiO2?)

[0049] QO2=(FiO2-21%) / 79%*Qtotal (Formula 1)

[0050]

[0051] In some embodiments, the table shown above or a similar table (with more or fewer adsorption units) can be configured into the control unit 202 to control the operation of the oxygen concentrator module 308. It can be seen that when the total oxygen production target changes, such as through the operator interface, the control unit 202 can control the working state of each adsorption unit according to the table. For example, when FiO2 is set to 25% to produce 10 LPM of oxygen, only one adsorption unit is turned on by the control unit 202; and when FiO2 is set to 40% to produce 30 LPM of oxygen, two adsorption units are turned on by the control unit 202.

[0052] Attention is now directed to the pressure valve 406. As shown in this example, in some embodiments, the pressure valve 406 is used to push oxygen from an adsorption unit in a first state to another adsorption unit in a second state during a given period of time to promote the release of N2 in the adsorption unit in the second state. For example, by way of illustration, and therefore not intended to be limiting, during a first period of time in which adsorption unit #1 404a produces concentrated oxygen, the pressure valve 406 is passed to allow the concentrated oxygen to flow from adsorption unit #1 404a to adsorption unit #n 404n. This helps to improve the release of N2 in adsorption unit #n 404n because the inflowing oxygen can accelerate the release of N2. Similarly, during a second period of time in which adsorption unit #n 404n is set to the first state to produce concentrated oxygen, the pressure valve 406 can be controlled by the control unit 202 to promote the flow of oxygen from adsorption unit #n 404n to adsorption unit #1 404a, thereby improving the release of N2 therein.

[0053] It should be understood that the number of adsorption units operating in parallel or alternating is a design choice and is not intended to be limited by Figure 4 The examples shown are not limiting. For example, adsorption unit #2 404b can be configured to operate in parallel with adsorption unit #1 404a or in parallel with adsorption unit #n 404n. This selection can be dynamically controlled by the control unit 202 based on the treatment plan, oxygen demand, entrainment factors, and / or any other considerations.

[0054] In one embodiment, the instance 400 of the oxygen concentrator module 308 includes an oxygen detector 408 configured to detect the fraction of oxygen content in the generated concentrated oxygen. In this instance, as shown, the oxygen detector 408 is arranged at the outlet path of the oxygen storage module 310. The concentration level of oxygen can be detected by the oxygen detector 408, so that when the concentration level in oxygen begins to drop below a threshold, the control unit 202 can be triggered to increase the production of concentrated oxygen - for example, by placing more adsorption units in parallel operation. The threshold level of oxygen concentration level can be preset in the control unit 202, for example, so that when the oxygen concentration level detected by the oxygen detector is determined to be lower than the preset oxygen concentration level, the control unit 202 is configured to generate a control signal to control the operation state of the adsorption unit in the instance 400 of the oxygen concentrator module 308.

[0055] In some embodiments, the oxygen concentration level may vary due to the attenuation of the material used in a given adsorption unit in the integrated oxygen supply device. In those embodiments, the oxygen concentration is closed-loop controlled and monitored. In one embodiment, two oxygen concentration sensors #1 and #2 are installed in the example 400. The oxygen concentration sensor #11 is installed at the oxygen storage module 310 or downstream before its blower. The oxygen concentration sensor #2 is installed downstream of the mixing point. In this embodiment, the air entrained by the blower can be adjusted based on the feedback measurement of sensor #1. When the generated oxygen concentration decreases, the flow rate of the flow control valve will increase to maintain the concentration of the mixed oxygen. In this embodiment, the oxygen concentration sensor #2 is used to monitor the mixed oxygen concentration. This provides additional safety for the mixed oxygen concentration. If the oxygen sensor #1 fails or the oxygen flow sensor fails, it can be detected by the oxygen concentration sensor #2 in this case.

[0056] In some embodiments, vacuum pressure swing adsorption (VPSA) oxygen production is used in an integrated oxygen supply device according to the present disclosure. In these embodiments, VPSA oxygen production involves vacuum pressure swing adsorption. Nitrogen is released by negative pressure. In a VPSA system, the operating pressure of the compressor 302 is lower than that of a PSA and less heat is generated.

[0057] Figure 5Another example 500 of an integrated oxygen supply device according to the present disclosure is shown. It can be seen that the example 500 of the integrated oxygen supply device includes a vacuum pump 502. It can be seen that the vacuum pump 502 is used in this example to apply a vacuum to the oxygen concentration module 308 to facilitate the N2 exhaust port in this example. In this way, together with the pressurized gas provided to the oxygen concentration module 308, a vacuum pressure swing adsorption (VPSA) system is implemented. Example 500 provides a higher recovery rate for the adsorption unit, resulting in a smaller compressor, blower or other compressed gas or vacuum source, and thus reducing power consumption. The higher productivity of example 500 also results in a smaller adsorption unit. In one embodiment, the operating conditions of the compressor 302 can be reduced to 25PSIA, while the operating conditions of the blower are set to 5PSIA.

[0058] Figure 6 Shows the control Figure 4 600 for an oxygen concentrator module. The operations of method 600 presented below are intended to be illustrative. In some embodiments, method 600 may be accomplished with one or more additional operations not described and / or one or more operations not discussed. Figure 6 The order shown and described below is not limiting.

[0059] In some embodiments, the method 600 may be implemented by the control unit 202, which may be implemented by one or more processors, such as Figure 2 The processor shown. The processor may include a digital processor, an analog processor, a digital circuit designed to process information, an analog circuit designed to process information, a state machine, and / or other mechanisms for electronically processing information. The control unit 202 may perform some or all of the operations of the method 600 in response to instructions stored electronically on an electronic storage medium. The control unit 202 may include one or more components configured by hardware, firmware, and / or software, which are designed to perform one or more operations of the method 600.

[0060] At 602, the oxygen concentration level produced by the oxygen concentrator module is determined to be below a threshold. In some embodiments, as described above, oxygen detectors may be arranged around the outlet of the oxygen concentrator module to detect the oxygen concentration level produced by the oxygen concentrator module. In implementations, readings of the oxygen concentration level detected by the oxygen detector may be stored in a memory. Readings may be obtained from time to time at 602. The threshold may be preset or may be dynamically set by the control unit 202 based on a treatment plan, the patient's oxygen demand, entrainment targets, and / or any other considerations.

[0061] For example, a threshold of 90% may be set for the concentration level. However, it should be understood that the threshold used at 602 may be a design choice such that it may be set to control the oxygen concentration level. Higher concentration levels will require higher thresholds, and vice versa. A higher threshold will mean that more adsorption units are working in parallel in the oxygen concentration module in a given time period, which may increase the required resources and thus increase the cost of producing oxygen by the oxygen concentration module 308. However, on the other hand, a higher oxygen concentration level will mean providing better oxygen-enriched air to the patient, and when the patient is in a worse condition, a higher oxygen flow rate and concentration in the air provided to the patient is required. In one embodiment, the threshold used at 602 may be adjustable by an operator. In this embodiment, an interface is provided to help the operator adjust the threshold to control the oxygen concentration level of the oxygen-enriched air released by the air separation unit.

[0062] In some embodiments, the threshold level at 602 can be dynamically adjusted through an interface provided by the integrated oxygen supply device. For example, the interface can be configured to enable an operator of the integrated oxygen supply device to select a preset oxygen supply mode that can correspond to a range of oxygen concentration levels in oxygen-enriched air. For example, an oxygen supply mode corresponding to an oxygen concentration level of 26%-30% can be provided to assist the patient in breathing. As will be described, this can help improve the efficiency and power consumption of the integrated oxygen supply device.

[0063] At 604, the first adsorption unit is switched out of operation. For example, as described and shown herein, this can be achieved by switching a switching valve connected to the first adsorption unit to a second state. In the second state, the first adsorption unit is configured to release the adsorbed N2 to the environment, which can increase the oxygen generation efficiency of the first adsorption unit.

[0064] At 606, the second adsorption unit is switched into operation. Although in this example, 604 and 606 are shown sequentially, in implementation, these two operations may occur simultaneously or nearly simultaneously. For example, the control unit 202 may switch the switching valve of the second adsorption unit to the first state mentioned and shown herein. In the first state, the switching valve facilitates the second adsorption unit to receive pressure-regulated air to produce concentrated oxygen. In implementation, multiple adsorption units may be configured to work in parallel with the second adsorption unit to increase the oxygen concentration level.

[0065] At 608, it is determined that a preset time period has expired. For example, the preset time period may be 6 seconds. At 610, the second adsorption unit is switched out of operation because the preset time period has expired. As described above, the preset time period may be used to control the operation duration after the second adsorption unit is switched into operation. For example, the control unit 202 may be configured to switch a switching valve connected to the second adsorption unit to a second state to trigger the second adsorption unit to release the adsorbed nitrogen.

[0066] At 612, the first adsorption unit is switched into operation. Although in this example, 610 and 612 are shown sequentially, in implementation, these two operations may occur simultaneously or nearly simultaneously. For example, the control unit 202 may be configured to switch a switching valve connected to the first adsorption unit to a first state to trigger the first adsorption unit to absorb nitrogen from the received air, thereby producing concentrated oxygen.

[0067] Figure 7 Shows Figure 2 700 of the gas regulating unit 206 shown. In this example, the example 700 of the gas regulating unit 206 includes a pressure regulator 702, a flow control valve 704, a blower 706, a heating / humidification unit 708 and / or any other components. The pressure regulator 702 is configured to regulate the concentrated oxygen from the oxygen generation unit 204 to a desired pressure level. In one embodiment, the desired pressure level is 8 PSI and is controlled by the control unit 202. In implementation, such regulation can be dynamically controlled by the control unit 202 based on the pressure level of the concentrated oxygen generated by the oxygen generation unit 204. For example, a sensor can be arranged to detect the pressure level of the concentrated oxygen level.

[0068] The flow control valve 704 is controlled by the control unit 202 to adjust the flow rate of concentrated oxygen produced by the oxygen generation unit 204 to a desired flow rate. In one embodiment, the desired pressure level is 15 LPM and is controlled by the control unit 202. In implementation, this adjustment can be dynamically controlled by the control unit 202 according to the flow rate of concentrated oxygen produced by the oxygen generation unit 204. For example, a sensor can be arranged to detect the flow rate level of the concentrated oxygen level. In some embodiments, the flow control valve 704 operates in two modes. One is a continuous flow mode, in which the flow rate is adjusted according to the patient's demand flow rate. The other is a pulsation mode, in which pulsations of oxygen are released to the blower 706. In implementation, the control unit 202 can control the pulsation amplitude and adjust the electrical power of the valve by measuring the oxygen flow rate of each pulsation.

[0069] The blower 706 is configured to receive ambient air and pressure and flow rate regulated oxygen and output mixed air at a desired FiO2 level (e.g., 40 / 40). The blower 706 is configured to combine ambient air with concentrated oxygen produced by the oxygen generation unit 204 at a desired FiO2 ratio. The desired FiO2 ratio can be determined to achieve the final oxygen fraction delivered to the patient. In one embodiment, the desired ration is determined by the patient's physiological characteristics and treatment requirements.

[0070] In some embodiments, the flow rate of ambient air and the flow rate of oxygen injected into the blower 706 are independently controlled by the control unit 202 before they are mixed in the blower 706. For example, in one embodiment, the control unit 202 is configured to adjust the oxygen concentration level of the mixed air by adjusting the flow rate of oxygen or the flow rate of ambient air. In some embodiments, a sensor is arranged at the outlet of the blower 706 to monitor the oxygen concentration level from the blower 706, and the monitored concentration level is reported to the control unit 202 from time to time to help the control unit 202 adjust the oxygen concentration level in the mixed air. For example, the control unit 202 is configured to operate the oxygen generation unit 204 according to the desired FiO2 level of the air mixed at the blower 706. For example, the control unit 202 can control the flow rate of oxygen from the oxygen generation unit to achieve the desired FiO2. As described above, the control unit 202 is configured to achieve the desired FiO2 of the mixed air by independently controlling the flow rate of ambient air entering the blower 706.

[0071] In some embodiments, the control unit 202 is configured to control the flow rate of ambient air and the flow rate of oxygen to achieve a mixing ratio of the mixed air without using the blower 706. In those embodiments, a valve can be used to combine the ambient air and the oxygen. In some embodiments, the ambient air can flow in one channel and the oxygen can flow in another channel, such as two different pipes. In those embodiments, the ambient air and the oxygen are combined to obtain the mixed air. In those embodiments, the control unit 202 is configured to achieve a desired FiO2 of the mixed air. For example, the control unit 202 is configured to control the flow rate of ambient air and the flow rate of oxygen.

[0072] The heating / humidification unit 708 is configured to heat the gas to a desired temperature point. The temperature of the gas inhaled by the patient affects the comfort of the patient 102 and subsequently affects the compliance of the treatment. The temperature of the inhaled gas can also affect the physiological response of the patient's respiratory system. The gas temperature affects the humidification level that can be achieved by the inhaled gas, which subsequently affects the therapeutic effect and potential side effects of the treatment. Therefore, precise temperature control is important for ensuring the temperature of the inhaled gas at the nasal cannula. Typically, the temperature of the gas inhaled by the patient is set at 37 degrees or slightly lower, which is supported by previous clinical studies. The advantage of the heating / humidification unit 708 is that air conditioning is achieved by adjusting the heating / humidification unit 708 by the control unit 202, rather than by some conventional methods, such as through a film.

[0073] The heating / humidification unit 708 is configured to humidify the heated gas. Normally, the upper respiratory tract of a healthy person humidifies the inhaled air to a saturation level at a body temperature close to thirty-seven degrees Celsius (37°C). If natural respiratory humidification fails, lung infection and lung tissue damage may result. The proper humidity level is critical to the healthy functioning of the human respiratory system and effective ventilator therapy. Because the flow rate of the invented respiratory device is significantly greater than the normal inspiratory flow rate to which the human respiratory system is accustomed, the natural respiratory system may not be able to provide the sufficient humidification required. Therefore, when using a ventilator, it is necessary to increase the humidity level of the heated gas to relieve the burden on the human respiratory system.

[0074] In various embodiments, the humidity and heat added to the mixed gas by the gas conditioning unit 206 makes the inspired gas delivered to the patient more palatable, especially at higher flow rates. The most effective humidification is pass-through humidification, where the gas passes over the top of heated water, additional water vapor is added, and the gas is also heated by the thermal energy transferred from the warm water. An electrical heating element is used to heat the water, and a closed loop temperature / humidity control is employed. This process is energy intensive due to the dissipation of thermal energy and thermal conductivity losses. In one embodiment, a heated water reservoir is used as the humidification subunit 2078 and the heating subunit 2076 in the integrated oxygen supply 100. In this embodiment, the temperature of the reservoir is set at a predetermined value based on a temperature humidity lookup table.

[0075] In another embodiment, the temperature sensor and humidity sensor are arranged to detect the temperature and humidity of the inhaled gas at or near the nasal cannula leading to the patient. In this embodiment, a feedback control mechanism is applied in the control unit 202 to control the heating / humidification unit 708 to ensure that the desired temperature and humidity level of the inhaled gas is achieved at the nasal cannula.

[0076] Figure 8Another exemplary embodiment of an integrated oxygen supply device 800 according to the present disclosure is shown. It can be seen that the integrated oxygen supply device 800 includes two sieve beds that work alternately and are controlled by a control unit. In this example, the switching valve is controlled by the control unit. The switching valve is controlled to switch at intervals of 5 seconds. At a given time, one sieve bed works in an oxygen production state. In this example, at 50PSI, N2 is absorbed by the working sieve bed, and concentrated oxygen is produced and stored in a product tank. The non-working sieve bed is in a circulating state-wherein the switching valve is opened to the ambient environment and nitrogen is released from the non-working sieve bed.

[0077] In some embodiments, the integrated oxygen supply 800 has a reduced size. In one embodiment, the integrated oxygen supply has a size of 15 (length) * 8 (height) * 19 (width) inches, can produce gas at 40 / 40FiO2, and weighs less than 30 pounds.

[0078] Fig. 9 Another example of an integrated oxygen supply according to the present disclosure is shown. In this embodiment 900, it can be seen that a vacuum pump is added to the circuit to apply vacuum to the N2 exhausted from the sieve beds. In this way, VPSA is achieved in the example 900.

[0079] Exemplary Computer System

[0080] Any computer systems mentioned herein may utilize any suitable number of subsystems. Figure 8 An example of such a subsystem is shown in the computer system 10 in FIG. 1 , which can be configured to implement the various features and / or functions described herein. In some embodiments, the computer system includes a single computer device, wherein the subsystem can be a component of the computer device. In other embodiments, the computer system can include multiple computer devices, each of which is a subsystem with internal components.

[0081] Figure 8 The subsystems shown are interconnected via a system bus 75. Additional subsystems are shown such as a printer 74, a keyboard 78, a storage device 79, a display 76 coupled to a display adapter 82, and the like. Peripheral devices and input / output (I / O) devices coupled to the I / O controller 71 may be connected to the computer system by any number of means known in the art, such as input / output (I / O) ports 77 (e.g., USB, ). For example, I / O port 77 or external interface 81 (e.g., Ethernet, Wi-Fi, etc.) can be used to connect computer system 10 to a wide area network, such as the Internet, a mouse input device, or a scanner. Interconnection via system bus 75 allows central processor 73 to communicate with each subsystem and control the execution of instructions from system memory 72 or storage device 79 (e.g., a fixed disk such as a hard disk or optical disk), as well as the exchange of information between subsystems. System memory 72 and / or storage device 79 can be embodied as a computer-readable medium. Any data mentioned herein can be output from one component to another and can be output to a user.

[0082] The computer system may include multiple identical components or subsystems, for example connected together via external interfaces 81 or internal interfaces. In some embodiments, the computer systems, subsystems or devices may communicate via a network. In this case, one computer may be considered a client and another computer may be considered a server, where each computer may be part of the same computer system. Both the client and the server may include multiple systems, subsystems or components.

[0083] It should be understood that any embodiment of the present invention can be implemented in the form of control logic using hardware (e.g., an application specific integrated circuit or a field programmable gate array) and / or using computer software and a general-purpose programmable processor in a modular or integrated manner. As used herein, a processor includes a single-core processor, a multi-core processor on the same integrated chip, or multiple processing units on a single circuit board or networked. Based on the disclosure and teachings provided herein, those of ordinary skill in the art will know and understand other ways and / or methods of implementing embodiments of the present invention using hardware and combinations of hardware and software.

[0084] Any software component or function described in this application can be implemented as a software code executed by a processor using any suitable computer language, such as Java, C, C++, C#, Objective-C, Swift or a scripting language such as Perl or Python, using, for example, conventional or object-oriented techniques. The software code can be stored as a series of instructions or commands on a computer-readable medium for storage and / or transmission, and suitable media include random access memory (RAM), read-only memory (ROM), magnetic media (such as a hard disk or floppy disk), or optical media (such as a compact disk (CD) or DVD (digital versatile disk), flash memory). The computer-readable medium can be any combination of such storage or transmission devices.

[0085] Such programs can also be encoded and transmitted using carrier signals suitable for transmission via wired, optical and / or wireless networks that meet various protocols (including the Internet). Therefore, the data signal of such program encoding can be used to create a computer-readable medium according to an embodiment of the present invention. The computer-readable medium encoded with program code can be packaged together with compatible devices, or provided separately from other devices (for example, downloaded via the Internet). Any such computer-readable medium can reside on or inside a single computer product (for example, hard disk, CD or entire computer system), and can be present on or inside different computer products in a system or network. The computer system can include a monitor, a printer or other suitable display for providing any result mentioned herein to the user.

[0086] Any method described herein can be implemented in whole or in part with a computer system comprising one or more processors, which can be configured to implement these steps. Therefore, embodiments can be directed to a computer system configured to perform the steps of any method described herein, wherein there may be different components for performing corresponding steps or corresponding step groups. Although presented as numbered steps, the steps of the method herein can be performed simultaneously or in different orders. In addition, the parts of these steps can be used together with the parts of other steps from other methods. In addition, all or part of the steps can be optional. In addition, any step of any method can be performed by the module, circuit or other devices for performing these steps.

[0087] Without departing from the spirit and scope of embodiments of the invention, the specific details of a particular embodiment may be combined in any suitable manner. However, other embodiments of the invention may be directed to specific embodiments relating to each individual aspect or specific combinations of these individual aspects.

[0088] The above description of exemplary embodiments of the present invention has been presented for purposes of illustration and description. This is not intended to be exhaustive or to limit the invention to the precise form described, and many modifications and variations are possible in light of the above teachings. These embodiments were chosen and described in order to best explain the principles of the invention and its practical application, thereby enabling others skilled in the art to best utilize the invention in various embodiments and with various modifications suitable for the particular use contemplated.

[0089] Unless expressly stated otherwise, the use of “a,” “an,” or “the” is intended to mean “one or more.” Unless specifically stated to the contrary, the use of “or” is intended to mean an inclusive or rather than an exclusive or.

[0090] The two states are also for illustration purposes. For one embodiment, both remote commands and local commands for changing oxygen device settings may be accepted without requiring a state switch.

[0091] All patents, patent applications, publications, and descriptions mentioned herein are incorporated by reference in their entirety for all purposes. None of them is admitted to be prior art.

[0092] Several exemplary configurations have been described, and various modifications, alternative configurations, and equivalents may be used without departing from the spirit of the present disclosure. For example, the above elements may be components of a larger system, wherein other rules may take precedence over or otherwise modify the application of the present invention. Furthermore, many steps may be taken before, during, or after considering the above elements.

Claims

1. An oxygen supply device, comprising: Oxygen generating unit, control unit, blower and gas regulating unit, wherein, The oxygen generation unit includes a plurality of adsorption units, and the plurality of adsorption units include a first adsorption unit and a second adsorption unit; The blower is configured to: receive ambient air and oxygen generated by the oxygen generation unit and output mixed air at a desired FiO2 ratio; The gas conditioning unit is connected to the blower and is configured to: generate conditioned air using mixed air from the blower; and wherein the control unit is configured to: controlling the first adsorption unit and the second adsorption unit to operate independently of each other so that the first adsorption unit and the second adsorption unit operate alternately; and The flow rate of oxygen generated by the oxygen generation unit and the flow rate of ambient air entering the blower are independently controlled.

2. The oxygen supply device according to claim 1, wherein: The first adsorption unit is connected to a first valve; and wherein controlling the operation of the first adsorption unit includes controlling the first valve to switch to a first position, at which a circuit between the pressure regulator and the first adsorption unit is connected.

3. The oxygen supply device according to claim 1, wherein: The first adsorption unit is connected to a first valve; and controlling the operation of the first adsorption unit includes controlling the first valve to switch to a second position, at which a circuit between the vacuum pump and the first adsorption unit is connected.

4. The oxygen supply device according to claim 2, wherein: The control unit is further configured to: determining that a concentration level of oxygen generated by the oxygen generating unit is below a threshold value; and In response to determining that the concentration level of oxygen generated by the oxygen generation unit is below a threshold, the first valve is controlled to switch to the second position, wherein the adsorption unit is facilitated to separate oxygen and nitrogen when the first valve is in the second position.

5. The oxygen supply device according to any one of claims 1 to 4, wherein: The control unit is configured to control the first adsorption unit and the second adsorption unit to operate in parallel.

6. The oxygen supply device according to any one of claims 1 to 5, wherein: The oxygen generation unit further comprises a pressure valve connected to the adsorption unit; and wherein the control unit is configured to control the pressure valve to facilitate the concentrated oxygen generated by the adsorption unit to be released to at least one other adsorption unit in the oxygen supply device.

7. The oxygen supply device according to any one of claims 1 to 6, wherein: The gas generated by the oxygen supply device has an oxygen concentration level of at least higher than 21% and / or a flow rate of higher than 10 liters / minute.

8. An oxygen generating unit comprising: Oxygen generation module, blower and control unit, wherein, The oxygen generation module includes a plurality of adsorption units, and the plurality of adsorption units include a first adsorption unit and a second adsorption unit; The blower is configured to: receive ambient air and oxygen generated by the oxygen generating unit and output mixed air at a desired FiO2 ratio; and The control unit is configured to: controlling the first adsorption unit and the second adsorption unit to operate independently of each other so that the first adsorption unit and the second adsorption unit operate alternately; and The flow rate of oxygen generated by the oxygen generation module and the flow rate of ambient air entering the blower are independently controlled.

9. The oxygen generating unit according to claim 8, wherein: The first adsorption unit is connected to a first valve; and wherein controlling the operation of the first adsorption unit includes controlling the first valve to switch to a first position, at which a circuit between the pressure regulator and the first adsorption unit is connected.

10. The oxygen generating unit according to claim 8, wherein: The first adsorption unit is connected to a first valve; and controlling the operation of the first adsorption unit includes controlling the first valve to switch to a second position, at which a circuit between the vacuum pump and the first adsorption unit is connected.

11. The oxygen generating unit according to claim 9, wherein: The control unit is further configured to: determining that a concentration level of oxygen generated by the oxygen generating unit is below a threshold value; and In response to determining that the concentration level of oxygen generated by the oxygen generation unit is below a threshold, the first valve is controlled to switch to the second position, wherein the adsorption unit is facilitated to separate oxygen and nitrogen when the first valve is in the second position.

12. The oxygen generation unit according to any one of claims 8 to 11, wherein: The control unit is configured to control the first adsorption unit and the second adsorption unit to operate in parallel.

13. The oxygen generation unit according to any one of claims 8 to 12, wherein: The oxygen generation unit further comprises a pressure valve connected to the adsorption unit; and wherein the control unit is configured to control the pressure valve to facilitate the concentrated oxygen generated by the adsorption unit to be released to at least one other adsorption unit in the oxygen generation unit.

14. The oxygen generation unit according to any one of claims 8 to 13, wherein: The gas generated by the oxygen generation unit has an oxygen concentration level of at least higher than 21% and / or a flow rate of higher than 10 liters / minute.

15. An oxygen supply device, comprising: control unit, a blower and a gas conditioning unit, wherein: The gas regulating unit comprises a pressure regulating unit connected to the oxygen supply device; and wherein the control unit is configured to: controlling the pressure regulating unit to regulate the pressure of the oxygen generated by the oxygen supply device; and The flow rates of oxygen and ambient air entering the blower are independently controlled.

16. The oxygen supply device according to claim 15, further comprising an oxygen concentration module, wherein the oxygen concentration module comprises a plurality of adsorption units, wherein the plurality of adsorption units comprises a first adsorption unit and a second adsorption unit; and wherein, The control unit is further configured to control the first adsorption unit and the second adsorption unit to operate alternately.

17. The oxygen supply device according to claim 16, wherein: The first adsorption unit is connected to a first valve; and controlling the operation of the first adsorption unit includes controlling the first valve to switch to a second position, at which a circuit between the vacuum pump and the first adsorption unit is connected.

18. The oxygen supply device according to claim 16 or 17, wherein: The control unit is configured to control the first adsorption unit and the second adsorption unit to operate in parallel.

19. The oxygen supply device according to any one of claims 16 to 18, wherein: The oxygen supply device further comprises an oxygen generation unit comprising a pressure valve connected to the adsorption unit; and wherein the control unit is configured to control the pressure valve to facilitate the concentrated oxygen generated by the adsorption unit to be released to at least one other adsorption unit in the oxygen supply device.

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