Brain-computer interface system and use method thereof

Abstract

The invention relates to a brain-computer interface system and a use method thereof, and the system comprises a hard base which is fixedly provided with a plurality of hard microneedles; the flexible electrode substrate is detachably connected to the hard base, a plurality of flexible electrode microneedles are integrally formed on the flexible electrode substrate, and the flexible electrode microneedles are detachably connected to the hard microneedles. By arranging the hard base, the flexible electrode substrate can be driven by the hard base to move to the designated depth in the brain tissue to be detected, the flexible electrode microneedle can also be supported by the hard microneedle, and the flexible electrode substrate and the flexible electrode microneedle move to the designated depth in the brain tissue to be detected together; the flexible electrode microneedle is fixed to the to-be-tested brain tissue, and the hard microneedle is separated from the flexible electrode microneedle, so that the hard base can drive the hard microneedle to move out of the to-be-tested brain tissue, and the technical problems that the flexible electrode cannot be integrally implanted at one time in an operation, the operation steps are relatively complicated, and the operation time is prolonged are solved.

Description

Technical Field

[0001] The present application relates to the field of biomedical engineering, and specifically to a brain-computer interface system and a method of using the same. Background Art

[0002] Currently, high-throughput array microneedle systems are usually made of hard materials, and the electrode contacts are directly attached to the silicon substrate through MEMS processing.

[0003] Because a single electrode is at the micron level and the silicon substrate of the electrode is brittle and lacks toughness, after the array microneedle is implanted in the brain tissue, during exercise and other processes, the brain tissue and the microneedle produce a large relative displacement. If the microneedle breaks in the brain, it can easily pose a safety hazard.

[0004] In the related technology, although there are microneedle systems that use flexible electrodes, they cannot be implanted as a whole in one operation, the operation steps are relatively complicated, and the operation time is increased. Summary of the invention

[0005] The present application provides a brain-computer interface system and a method for using the same, which can solve the technical problems in related technologies that flexible electrodes cannot be implanted as a whole in one operation, the operation steps are relatively complicated, and the operation time is increased.

[0006] In a first aspect, an embodiment of the present application provides a brain-computer interface system, comprising: a hard base, to which a plurality of hard microneedles are fixed; a flexible electrode base, to which the flexible electrode base is detachably connected, the flexible electrode base being integrally formed with a plurality of flexible electrode microneedles, and the flexible electrode microneedles being detachably connected to the hard microneedles.

[0007] In combination with the first aspect, in one embodiment, the hard base is provided with a plurality of first through-holes arranged at intervals, the flexible electrode substrate is provided with a plurality of second through-holes respectively arranged corresponding to the first through-holes, and the first through-holes and the corresponding second through-holes are provided with positioning wires.

[0008] In combination with the first aspect, in one embodiment, each of the flexible electrode microneedles is provided with a through groove on a side away from the flexible electrode substrate; each of the hard microneedles is provided with a locking mechanism on a side away from the hard base, and the locking mechanism is locked in the through groove.

[0009] In combination with the first aspect, in one embodiment, the locking mechanism includes: a first boss, the first boss is fixed to one side of the hard microneedle; a second boss, the second boss is fixed to the side of the first boss away from the hard microneedle, and the second boss and the hard microneedle form a bayonet with an opening, and at least part of the flexible electrode microneedle is clamped in the bayonet; a side of the first boss away from the second boss, and a side of the second boss close to the first boss are both provided with a pushing inclined surface.

[0010] In combination with the first aspect, in one embodiment, a conical needle head is fixed to the end of each hard microneedle away from the hard base, and the tip of the conical needle head is located at the end of the hard microneedle away from the hard base.

[0011] In combination with the first aspect, in one embodiment, the conical needle head protrudes in a direction perpendicular to the extension direction of the hard microneedle to form a platform, the platform and the second boss are located on the same side of the hard microneedle, and the platform and the bayonet are spaced apart along the extension direction of the hard microneedle.

[0012] In combination with the first aspect, in one embodiment, the brain-computer interface system further includes: a sacrificial layer, wherein the sacrificial layer is respectively sandwiched between the flexible electrode base and the hard base, and between the flexible electrode microneedle and the hard microneedle.

[0013] In combination with the first aspect, in one embodiment, the sides of the flexible electrode microneedles are provided with micro-barb structures.

[0014] In the second aspect, an embodiment of the present application provides a method for using a brain-computer interface system, which adopts the above-mentioned brain-computer interface system, and includes the following steps: driving the hard base to drive the flexible electrode base to move toward the direction close to the brain tissue to be tested, and inserting it to a specified depth in the brain tissue to be tested; separating the flexible electrode base from the hard base, and driving the hard base to drive the hard microneedle to move out of the brain tissue to be tested.

[0015] In combination with the second aspect, in one embodiment, the flexible electrode microneedle is provided with a through groove, and a locking mechanism is provided on one side of the hard microneedle, and the driving of the hard base drives the hard microneedle to move out of the brain tissue to be tested, including: driving the hard base to drive the hard microneedle to move in a direction away from the brain tissue to be tested, so that the locking mechanism of the hard microneedle moves along the through groove of the flexible electrode microneedle; when the pushing inclined surface of the locking mechanism abuts the end of the through groove, the hard base is continuously driven to drive the hard microneedle to move in a direction away from the brain tissue to be tested, so that the pushing inclined surface lifts the flexible electrode microneedle, and the hard microneedle is out of the flexible electrode microneedle.

[0016] The beneficial effects brought by the technical solution provided in the embodiments of the present application include:

[0017] By setting up a hard base, the flexible electrode base can be moved to a specified depth in the brain tissue to be tested under the drive of the hard base, the flexible electrode microneedle can also be supported by the hard microneedle and move together to the specified depth in the brain tissue to be tested, and the hard microneedle can also be driven by the hard base to move to the specified depth in the brain tissue to be tested. After moving to the specified depth in the brain tissue to be tested, the flexible electrode microneedle is fixed to the preset brain tissue, the hard base is separated from the flexible electrode base, and the hard microneedle is also separated from the flexible electrode microneedle, so that the hard base can drive the hard microneedle to move out of the brain tissue to be tested, solving the technical problems in related technologies that the flexible electrode cannot be implanted as a whole in one operation, the operation steps are relatively complicated, and the operation time is increased. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0019] Figure 1 A schematic diagram of the local structure of the connection between the hard microneedle and the flexible electrode microneedle provided in the embodiment of the present application;

[0020] Figure 2 A schematic diagram of the front view structure of the flexible electrode substrate and the flexible electrode microneedle provided in the embodiment of the present application;

[0021] Figure 3 A schematic diagram of the structure of a rigid substrate provided in an embodiment of the present application;

[0022] Figure 4 A schematic diagram of the structure of the connection between the hard base and the flexible electrode base provided in the embodiment of the present application;

[0023] Figure 5 A schematic diagram of the structure in which the hard base and the flexible electrode base are separated according to an embodiment of the present application.

[0024] In the figure:

[0025] 1. Hard base; 11. First perforation; 12. Auxiliary connection mechanism;

[0026] 2. hard microneedle; 21. first boss; 22. second boss; 23. bayonet; 24. conical needle head; 241. platform; 25. push ramp;

[0027] 3. flexible electrode substrate; 31. second perforation;

[0028] 4. Flexible electrode microneedle; 41. Through groove; 42. Micro barb structure;

[0029] 5. Positioning thread;

[0030] 6. Base extension section;

[0031] 7. CMOS circuit;

[0032] 8. Microstrip line;

[0033] 9. Rigid substrate; 91. Trough body;

[0034] 10. Sacrificial layer. DETAILED DESCRIPTION

[0035] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0036] The embodiment of the present application provides a brain-computer interface system, which can solve the technical problems in the related art that flexible electrodes cannot be implanted as a whole in one operation, the operation steps are relatively complicated, and the operation time is increased.

[0037] See also Figure 1 As shown, a brain-computer interface system provided by an embodiment of the present application may include: a hard base 1, the hard base 1 is fixed with a plurality of hard microneedles 2, and the hard base 1 and the plurality of hard microneedles 2 may be integrally formed; a flexible electrode substrate 3, the flexible electrode substrate 3 is detachably connected to the hard base 1, the flexible electrode substrate 3 is integrally formed with a plurality of flexible electrode microneedles 4, and the flexible electrode microneedle 4 is detachably connected to the hard microneedle 2, and the flexible electrode substrate 3 and the flexible electrode microneedle 4 may also be integrally formed. In the embodiment of the present application, the hard base 1 may be an electrode silicon substrate, the width and thickness of which are both in the micron level, and the hard microneedle 2 may be the head end of the silicon substrate; the flexible electrode substrate 3 may be made of highly biocompatible materials such as polyimide or polyurethane, parylene, and the material of the flexible electrode microneedle 4 may be platinum or platinum iridium, iridium oxide, titanium nitride and other biocompatible metal materials.

[0038] The embodiment of the present application sets a hard base 1 so that the flexible electrode base 3 can be moved to a specified depth in the brain tissue to be tested under the drive of the hard base 1. The hard base 1 can serve as a support for the flexible electrode base 3, so that the flexible electrode base 3 can move with the hard base 1, and the hard base 1 is fixed with a plurality of hard microneedles 2, and the flexible electrode base 3 is fixed with a plurality of flexible electrode microneedles 4 corresponding to the hard microneedles 2, that is, each flexible electrode microneedle 4 corresponds to a hard microneedle 2, so that each flexible electrode microneedle 4 is supported by a corresponding hard microneedle 2, and the hard microneedle 2 is fixed to the hard base 1, so when the hard base 1 moves, the hard microneedle 2 also moves. With synchronous movement, the hard microneedle 2 and the flexible electrode microneedle 4 can move together with the hard base 1 to the specified depth in the brain tissue to be tested. After moving to the specified depth in the brain tissue to be tested, the flexible electrode microneedle 4 is fixed to the brain tissue to be tested, and the hard base 1 is separated from the flexible electrode base 3. The separation method can be to remove or disassemble the connecting mechanism between the hard base 1 and the flexible electrode base 3, and the hard microneedle 2 and the flexible electrode microneedle 4 are also separated, so that the hard base 1 and the hard microneedle 2 can be moved away from the brain tissue to be tested, which solves the technical problem that the flexible electrode used in the related technology cannot be implanted as a whole in one operation, the operation steps are relatively complicated, and the operation time is increased.

[0039] See also Figure 2 As shown, in some optional embodiments, the hard base 1 is provided with a plurality of first through-holes 11 arranged at intervals, and the flexible electrode substrate 3 is provided with a plurality of second through-holes 31 respectively arranged corresponding to the first through-holes 11, and the first through-holes 11 and the corresponding second through-holes 31 are penetrated with positioning wires 5, that is, in the embodiment of the present application, the way to connect the hard base 1 and the flexible electrode substrate 3 is to respectively open the first through-hole 11 and the second through-hole 31 on the hard base 1 and the flexible electrode substrate 3, penetrate the positioning wires 5 connecting them in the first through-hole 11 and the corresponding second through-hole 31, and in the subsequent surgical process, the positioning wires 5 can be cut with a scalpel to separate the hard base 1 and the flexible electrode substrate 3 from each other. In addition, a snap-fit ​​structure can also be provided between the flexible electrode substrate 3 and the hard base 1, specifically, a groove can be provided on the side of the flexible electrode substrate 3 away from the flexible electrode microneedle 4, and the hard base 1 is penetrated in the groove, so that the first through-hole 11 and the corresponding second through-hole 31 can be coaxially arranged, so as to reduce the overall volume of the brain-computer interface system as much as possible, and facilitate surgical operation. Preferably, the first through-hole 11 and the second through-hole 31 can be set to be micrometer-level, and the positioning thread 5 can be made of materials such as silk protein, polyimide, and parylene C.

[0040] In some optional embodiments, each of the flexible electrode microneedles 4 is provided with a through groove 41 on the side away from the flexible electrode substrate 3; each of the hard microneedles 2 is provided with a snap-fit ​​mechanism on the side away from the hard base 1, and the snap-fit ​​mechanism is snap-fitted in the through groove 41. The through groove 41 may extend along the length direction of the flexible electrode microneedle 4, and the through groove 41 penetrates the flexible electrode microneedle 4 along the thickness direction of the flexible electrode microneedle 4. The through groove 41 is provided on the side of the flexible electrode microneedle 4 away from the flexible electrode substrate 3, which means that the distance between the end of the flexible electrode microneedle 4 away from the flexible electrode substrate 3 and the through groove 41 is small; the snap-fit ​​mechanism provided on the hard microneedle 2 may cooperate with the through groove 41, so that the snap-fit ​​mechanism is snap-fitted in the through groove 41, thereby realizing the mutual connection between the flexible electrode microneedle 4 and the hard microneedle 2. In the embodiment of the present application, by setting the through groove 41 and cooperating with the snap-fit ​​mechanism, the structural arrangement on the flexible electrode microneedle 4 and the hard microneedle 2 can be reduced as much as possible, and the flexible electrode microneedle 4 and the hard microneedle 2 can be connected to each other. In the subsequent surgical process, this setting method also makes it easier to separate the flexible electrode microneedle 4 from the hard microneedle 2, further reducing the difficulty of the operation and shortening the operation time.

[0041] See also Figure 1As shown, in some optional embodiments, the locking mechanism may include: a first boss 21, the first boss 21 is fixed to one side of the hard microneedle 2; a second boss 22, the second boss 22 is fixed to the side of the first boss 21 away from the hard microneedle 2, and the second boss 22 and the hard microneedle 2 form a bayonet 23 with an opening, and at least part of the flexible electrode microneedle 4 is clamped in the bayonet 23; a push inclined surface 25 is provided on the side of the first boss 21 away from the second boss 22, and on the side of the second boss 22 close to the first boss 21. It should be understood that the first boss 21 and the second boss 22 can be integrally formed with the hard microneedle 2, and the first boss 21 and the second boss 22 both protrude toward the side close to the flexible electrode microneedle 4. By setting the first boss 21, the side of the first boss 21 close to the second boss 22 can be coplanar with the side of the flexible electrode microneedle 4 away from the hard microneedle 2, that is, the first boss 21 is inserted into the through groove 41, and the first boss 21 can move in the through groove 41 along the length direction of the flexible electrode microneedle 4. The second boss 22 can fix the side of the first boss 21 away from the hard microneedle 2, and the second boss 22 protrudes toward the side away from the hard base 1, so that part of the second boss 22 and the hard microneedle 2 are spaced apart in a direction perpendicular to the extension direction of the hard microneedle 2 to enclose a bayonet 23, and at least part of the flexible electrode microneedle 4 is clamped in the bayonet 23 to achieve the connection between the flexible electrode microneedle 4 and the hard microneedle 2. In the embodiment of the present application, the first boss 21 and the second boss 22 can be step hook-like structures formed by multi-layer MEMS processing technology, and by respectively providing a push slope 25 on one side of the first boss 21 and the second boss 22, the push slope 25 can push the flexible electrode microneedle 4 when the hard microneedle 2 is separated from the flexible electrode microneedle 4, so that the flexible electrode microneedle 4 is fixed to the brain tissue to be tested.

[0042] In some optional embodiments, a conical needle 24 is also fixed to one end of each hard microneedle 2 away from the hard base 1, and the tip of the conical needle 24 is located at the end of the hard microneedle 2 away from the hard base 1. It should be understood that the conical needle 24 can also be integrally formed with the hard microneedle 2. The provision of a conical needle 24 with a tip at one end of the hard microneedle 2 helps to achieve more accurate positioning using the conical needle 24 during surgery, and the tip can better contact the brain tissue to form a stable electrical connection, so that medical staff can quickly determine whether the conical needle 24 has moved to the preset position for subsequent manipulation. By providing a conical needle 24, the accuracy of positioning can be increased, and medical staff can achieve quick and accurate judgments, further reducing the duration of surgery and increasing the completion rate of surgery.

[0043] In some optional embodiments, the conical needle head 24 protrudes in a direction perpendicular to the extension of the hard microneedle 2 to form a platform 241, the platform 241 and the second boss 22 are located on the same side of the hard microneedle 2, and the platform 241 and the bayonet 23 are spaced apart along the extension direction of the hard microneedle 2, the platform 241 can have the same contour as the conical needle head 24, and in the embodiment of the present application, the protruding height of the platform 241 can be smaller, which plays a fixing role in preventing the soft needle from falling out when the brain-computer interface system is implanted.

[0044] In some optional embodiments, the brain-computer interface system may further include: a sacrificial layer 10, the sacrificial layer 10 is respectively sandwiched between the flexible electrode substrate 3 and the hard base 1, and between the flexible electrode microneedle 4 and the hard microneedle 2. There may be a sacrificial layer 10 between the flexible electrode substrate 3 and the hard base 1, and there may also be a sacrificial layer 10 between the flexible electrode microneedle 4 and the hard microneedle 2. The sacrificial layer 10 located between the flexible electrode substrate 3 and the hard base 1 and between the flexible electrode microneedle 4 and the hard microneedle 2 may also be integrally formed. The material of the sacrificial layer 10 may be set to other materials such as silicon oxide, and the sacrificial layer 10 may be dissipated by chemical action. In the embodiment of the present application, under the action of the sacrificial layer 10, the flexible electrode substrate 3 and the hard base 1, as well as the flexible electrode microneedle 4 and the hard microneedle 2 can be quickly positioned during assembly, thereby improving positioning accuracy and assembly efficiency. Preferably, the sacrificial layer 10 between the flexible electrode substrate 3 and the hard base 1 may also be provided with a plurality of third through-holes of micrometer level, each of which corresponds to the first through-hole 11 and the second through-hole 31 respectively.

[0045] In some optional embodiments, the side surfaces of the flexible electrode microneedles 4 are provided with micro-barb structures 42. In the embodiment of the present application, by providing the micro-barb structures 42, it is convenient to fix the flexible electrode microneedles 4 to the brain tissue to prevent the electrode position from shifting.

[0046] In some optional embodiments, the flexible electrode substrate 3 may also be connected to a substrate extension section 6, and the flexible electrode of the substrate extension section 6 may not be supported by a hard substrate, that is, not connected to a silicon substrate, and a CMOS circuit 7 is connected to the end of the substrate extension section 6 away from the flexible electrode substrate 3, which can convert the collected electrophysiological model into a digital signal output, and the end of the CMOS circuit 7 away from the substrate extension section 6 may also be connected to a microstrip line 8. Further, in the embodiment of the present application, based on the micro-nano processing technology, the width of the flexible electrode microneedle 4 can be the same as the width of the hard microneedle 2, and the number of electrode channels can be selected according to the needs of the actual indications. After the flexible electrode microneedle 4 is fixed to the brain tissue, any number of contacts can be programmed through the post-CMOS circuit 7 and the host computer software to achieve electrophysiological signals and stimulation of the target brain area.

[0047] See also Figure 4 As shown, in some optional embodiments, an auxiliary connection mechanism 12 is fixed to the side of the hard base 1 away from the hard microneedle 2. The auxiliary connection mechanism 12 can be connected to the auxiliary stereotactic implantation device during surgery, and it can be provided in the form of an extension column. Further, in the embodiment of the present application, the hard base 1, the flexible electrode substrate 3, the hard microneedle 2 and the flexible electrode microneedle 4 can together form a comb-like structure, and multiple hard microneedles 2 and multiple flexible electrode microneedles 4 are integrated into a multi-row microneedle array; see Figure 3 and Figure 5 As shown, the brain-computer interface system can also include a rigid substrate 9. The material of the rigid substrate 9 can be medical steel with biocompatibility, etc. The length of the substrate is slightly larger than the single-row microneedles. It should be understood that the hard base 1, the multiple hard microneedles 2, the flexible electrode substrate 3 and the multiple flexible electrode microneedles 4 can together form a single-row microneedle. A plurality of grooves 91 are arranged on the rigid substrate 9. The length and width of each groove 91 are equivalent to the length and width of the hard substrate. After each row of microneedles is processed, a biocompatible glue is filled in the substrate slot, which is not limited to EPO- MED-301 bioglue, and then embed the single row of microneedles into the card slot and assemble them one by one.

[0048] The embodiment of the present application also provides a method for using a brain-computer interface system, which uses the above-mentioned brain-computer interface system and may include the following steps:

[0049] S1: Drive the hard base 1 to drive the flexible electrode base 3 to move toward the direction close to the brain tissue to be tested, and insert it into the specified depth in the brain tissue to be tested. The specified depth area in the brain tissue to be tested can be vertically above the implantation target area, and can also be assisted by a stereo positioning device. Before the brain-computer interface system is extended into the preset area, the sacrificial layer 10 can be washed with a chemical liquid.

[0050] S2: Separate the flexible electrode substrate 3 from the hard base 1, and drive the hard base 1 to move the hard microneedle 2 out of the brain tissue to be tested. That is, when the hard microneedle 2 and the flexible electrode microneedle 4 are inserted into the specified depth in the brain tissue to be tested and stop moving, separate the flexible electrode substrate 3 from the hard base 1. The flexible electrode substrate 3 and the hard base 1 can be separated by cutting the positioning thread 5 with surgical thread. After multiple flexible electrode microneedles 4 are placed in the brain tissue, all the flexible electrode microneedles 4 are arranged and left in the cortex, and then the dura mater is sutured, and finally the COMS and the transmission system are fixed to the skull. At this point, the implantation of the flexible electrode microneedle 4 in the target area is completed. The flexible electrode has the characteristics of high channel, bidirectional, and can move with the brain tissue without being easy to break.

[0051] In some optional embodiments, the flexible electrode microneedle 4 is provided with a through groove 41, and a locking mechanism is provided on one side of the hard microneedle 2. The driving of the hard base 1 to drive the hard microneedle 2 to move out of the brain tissue to be measured includes: driving the hard base 1 to drive the hard microneedle 2 to move in a direction away from the brain tissue to be measured, so that the locking mechanism of the hard microneedle 2 moves along the through groove 41 of the flexible electrode microneedle 4; when the pushing slope 25 of the locking mechanism abuts the end of the through groove 41, the hard base 1 is continuously driven to drive the hard microneedle 2 to move in a direction away from the brain tissue to be measured, so that the pushing slope 25 lifts the flexible electrode microneedle 4, and the hard microneedle 2 is out of the flexible electrode microneedle 4. After the hard base 1 is separated from the flexible electrode base 3, the hard base 1 drives the hard microneedle 2 to move in the direction opposite to the moving direction during insertion. When the inner side wall of the through groove 41 abuts against the pushing slope 25 of the first boss 21, the flexible electrode microneedle 4 can be lifted a certain distance, and then the hard microneedle 2 continues to move, and the inner side wall of the through groove 41 and the pushing slope 25 of the second boss 22 may also abut against each other, then the flexible electrode microneedle 4 continues to be lifted, and then the hard microneedle 2 continues to move until it is out of the brain tissue to be tested.

[0052] In the embodiment of the present application, multiple flexible electrode microneedles 4 can integrate ultra-high flux, bidirectional, low power consumption, and ultra-fine electrodes through MEMS process technology and CMOS circuit 7 integration technology, and can be implanted in the target area and can move with the brain tissue without breaking easily. In addition, multiple flexible electrode microneedles 4 are initially attached to the hard microneedles through the sacrificial layer 10. After the sacrificial layer 10 is removed, the snap-fit ​​structure is used to cooperate with the groove 41 to maintain the connection. After the hard microneedle with the flexible electrode microneedle 4 is implanted into the target brain area, the positioning thread 5 is disconnected, and the flexible electrode microneedle 4 can be automatically detached at one time, and the hard substrate of the embedded hard microneedle is removed from the implantation area. The flexible electrode microneedle 4 remains in the cortical area for a long time, realizing real-time electrophysiological detection and stimulation of brain areas such as cortical motor sensation. These two points overcome the shortcomings of the prior art hard microneedles that break in the brain tissue and are implanted multiple times and undergo long-term surgery.

[0053] In the description of the present application, it should be noted that the terms "upper", "lower", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application. Unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be a connection between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to the specific circumstances.

[0054] It should be noted that, in this application, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

[0055] The above description is only a specific implementation of the present application, so that those skilled in the art can understand or implement the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest range consistent with the principles and novel features applied for herein.

Claims

1. A brain-computer interface system, characterized in that: It includes: A hard base (1), wherein a plurality of hard microneedles (2) are fixed to the hard base (1); A flexible electrode substrate (3), wherein the flexible electrode substrate (3) is detachably connected to the hard base (1), the flexible electrode substrate (3) is integrally formed with a plurality of flexible electrode microneedles (4), and the flexible electrode microneedles (4) are detachably connected to the hard microneedles (2).

2. The brain-computer interface system according to claim 1, characterized in that: The hard base (1) is provided with a plurality of first through-holes (11) arranged at intervals, the flexible electrode base (3) is provided with a plurality of second through-holes (31) respectively arranged corresponding to the first through-holes (11), and the first through-holes (11) and the corresponding second through-holes (31) are provided with positioning wires (5).

3. The brain-computer interface system according to claim 1, characterized in that: Each of the flexible electrode microneedles (4) is provided with a through groove (41) on a side away from the flexible electrode substrate (3); A snap-fit ​​mechanism is provided on a side of each of the hard microneedles (2) away from the hard base (1), and the snap-fit ​​mechanism is snap-fitted into the through groove (41).

4. The brain-computer interface system according to claim 3, characterized in that: The engaging mechanism comprises: A first boss (21), wherein the first boss (21) is fixed to one side of the hard microneedle (2); A second boss (22), the second boss (22) being fixed to a side of the first boss (21) away from the hard microneedle (2), and the second boss (22) and the hard microneedle (2) enclose a bayonet (23) having an opening, and at least a portion of the flexible electrode microneedle (4) is bayoneted in the bayonet (23); A side of the first boss (21) away from the second boss (22), and a side of the second boss (22) close to the first boss (21) are both provided with a pushing inclined surface (25).

5. The brain-computer interface system according to claim 4, characterized in that: A conical needle head (24) is also fixed to one end of each hard microneedle (2) away from the hard base (1), and the tip of the conical needle head (24) is located at the end of the hard microneedle (2) away from the hard base (1).

6. The brain-computer interface system according to claim 5, characterized in that: The conical needle head (24) protrudes in a direction perpendicular to the extension direction of the hard microneedle (2) to form a platform (241); the platform (241) and the second boss (22) are located on the same side of the hard microneedle (2), and the platform (241) and the bayonet (23) are spaced apart in the extension direction of the hard microneedle (2).

7. The brain-computer interface system according to claim 1, characterized in that: The brain-computer interface system further comprises: A sacrificial layer (10) is respectively sandwiched between the flexible electrode substrate (3) and the hard base (1), and between the flexible electrode microneedle (4) and the hard microneedle (2).

8. The brain-computer interface system according to claim 1, characterized in that: The sides of the flexible electrode microneedles (4) are all provided with micro-barb structures (42).

9. A method for using a brain-computer interface system, characterized in that: The brain-computer interface system according to any one of claims 1 to 8 is used, and comprises the following steps: The hard base (1) is driven to drive the flexible electrode base (3) to move in a direction close to the brain tissue to be tested, and is inserted into the brain tissue to be tested to a specified depth; The flexible electrode substrate (3) is separated from the hard base (1), and the hard base (1) is driven to drive the hard microneedle (2) to move out of the brain tissue to be tested.

10. The method for using the brain-computer interface system according to claim 9, characterized in that: The flexible electrode microneedle (4) is provided with a through groove (41), one side of the hard microneedle (2) is provided with a snap-fit ​​mechanism, and the driving hard base (1) drives the hard microneedle (2) to move out of the brain tissue to be tested, comprising: The hard base (1) is driven to drive the hard microneedle (2) to move in a direction away from the brain tissue to be tested, so that the engaging mechanism of the hard microneedle (2) moves along the penetration groove (41) of the flexible electrode microneedle (4); When the pushing inclined surface (25) of the engaging mechanism abuts against the end of the through groove (41), the hard base (1) is continuously driven to drive the hard microneedle (2) to move in a direction away from the brain tissue to be tested, so that the pushing inclined surface (25) lifts up the flexible electrode microneedle (4), and the hard microneedle (2) is disengaged from the flexible electrode microneedle (4).

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