Yao bath effervescent ball for puerpera and preparation process thereof

Abstract

The invention relates to the technical field of gynecological health care samples, and discloses a puerpera Yao bath effervescent ball, which is prepared from the following traditional Chinese medicinal materials and auxiliary materials, and the traditional Chinese medicinal materials comprise, by mass, 4-6 parts of angelica sinensis, 8-12 parts of uncaria, 8-12 parts of astragalus membranaceus, 8-12 parts of negundo chastetree fruit, 8-12 parts of cassia twig, 12-18 parts of motherwort, 8-12 parts of senecio scandens, 4-6 parts of Indian kalimeris herb, 8-12 parts of artemisia apiacea, 4-6 parts of folium artemisiae argyi, 4-6 parts of lemongrass and 4-6 parts of schizonepeta. The invention further discloses a preparation process of the Yao bath effervescent ball for the puerpera. The Yao bath effervescent ball is prepared from the following traditional Chinese medicinal materials: Chinese angelica, uncaria, astragalus membranaceus, negundo chastetree fruit, cassia twig, motherwort, senecio scandens, Indian kalimeris herb, artemisia apiacea, folium artemisiae argyi, lemongrass and schizonepeta, and auxiliary materials are added to prepare the Yao bath effervescent ball. The Yao bath effervescent ball has the health-care effects of tonifying qi, harmonizing blood and regulating Chong and Ren meridians; and the health-care effect of promoting rehabilitation is achieved on fatigue and weakness, soreness and weakness of waist and knees, downward flow of damp-heat and endless lochia caused by qi and blood disorder of the puerpera.

Description

Technical Field

[0001] The invention relates to the technical field of gynecological health care samples, in particular to a Yaoyu effervescent ball for parturients and a preparation process thereof. Background Art

[0002] During childbirth, women's bone joints and tendons open up, and a lot of blood and physical strength are consumed during childbirth. Therefore, during the confinement period, the resistance and immunity of the mother decrease, and the six poisons of cold, dampness, summer heat, heat, wind and evil can easily invade the body. In addition, due to the decrease in the body's metabolic function during pregnancy and after childbirth, waste toxins accumulate in the body and cannot be metabolized out. If these cold, dampness and toxins cannot be excreted from the body when the tendons and bones gradually close during the full moon, it will bury hidden dangers for future health and form "confinement disease". Therefore, it is extremely necessary to prevent and regulate confinement disease in time;

[0003] After the mother soaks in the Yao bath, the medicinal liquid seeps into the body, which can effectively relieve or alleviate some of the discomfort of the mother; Chinese medicinal materials need to be added to the Yao bath. Summary of the invention

[0004] The object of the present invention is to provide a Yaoyu effervescent ball for parturients and a preparation process thereof, so as to solve the problems raised in the above-mentioned background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A Yaoyu effervescent ball for parturients is prepared from Chinese medicinal materials and auxiliary materials. The Chinese medicinal materials are composed of the following components by weight: 4-6 parts of angelica sinensis, 8-12 parts of Uncaria rhynchophylla, 8-12 parts of Astragalus membranaceus, 8-12 parts of Vitex negundo, 8-12 parts of cinnamon twig, 12-18 parts of Leonurus japonicus, 8-12 parts of Senecio truncatum, 4-6 parts of Amaranthus chinensis, 8-12 parts of Artemisia annua, 4-6 parts of Artemisia argyi, 4-6 parts of Cyperus rotundus and 4-6 parts of Nepeta tenuifolia.

[0007] The auxiliary materials are composed of the following by weight: 8 to 12 parts of soluble starch, 2 to 3 parts of polyvinyl pyrrolidone, 35 to 40 parts of citric acid, 35 to 40 parts of anhydrous sodium carbonate and 2 to 3 parts of sodium benzoate.

[0008] A preparation process of a Yaoyu effervescent ball for parturients comprises the following steps:

[0009] S1. Process optimization: Mix the Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cinnamomum cassia, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Nepeta tenuifolia in the mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), soak them in water and measure the water absorption rate; and under the condition of meeting the water absorption rate, take the paste yield of Chinese medicinal materials as an indicator and combine the production cost; determine the optimal amount of water added, soaking time, decoction time and decoction times of Chinese medicinal materials;

[0010] S2, filtrate preparation: take 4-6 parts of angelica, 8-12 parts of Uncaria rhynchophylla, 8-12 parts of Astragalus, 8-12 parts of Vitex negundo, 8-12 parts of cinnamon twig, 12-18 parts of Leonurus japonicus, 8-12 parts of Senecio radix, 4-6 parts of Amaranthus chinensis, 8-12 parts of Artemisia annua, 4-6 parts of Artemisia argyi, 4-6 parts of Cymbopogon citratus, 4-6 parts of Nepeta tenuifolia according to the mass parts, and soak, decoct and filter according to the determined amount of water added, soaking time, number of decoctions and decoction time, to obtain a filtrate and a medicinal residue;

[0011] S3, preparation of extract powder: after combining all the filtrates, heat and reduce pressure to concentrate to a relative density of 1.12 to 1.16 to obtain a clear paste, and spray dry it at 150° C. using a peristaltic pump to obtain an extract powder;

[0012] S4. Preparation of effervescent balls: Take 8-12 parts of soluble starch, 2-3 parts of polyvinyl pyrrolidone, 35-40 parts of citric acid, 35-40 parts of anhydrous sodium carbonate, and 2-3 parts of sodium benzoate by mass, spray-dry them at 150°C using a peristaltic pump, add them to the extract powder, mix and stir evenly; press them into effervescent balls of a set size; and put them into storage after packaging and inspection.

[0013] As a further solution of the present invention: in the step S1, the method for determining the water absorption rate of the medicinal material is as follows:

[0014] The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cassia twig, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Schizonepeta tenuifolia were mixed in the mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 9 times the weight of water until the weight of the medicinal materials no longer increases. The water absorption rate was measured at 0h, 1h, 2h, 4h and 6h respectively to determine the maximum water absorption rate of the medicinal materials.

[0015] As a further solution of the present invention: in the step S1, the soaking time is investigated based on the paste yield index under the condition that the Chinese medicinal materials meet the water absorption rate, and the determination method is as follows:

[0016] The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cinnamomum cassia, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Nepeta tenuifolia are mixed in a mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 9 times the weight of water for 0h, 0.5h, 1h, 3h and 5h, respectively, wherein the first soaking is added with corresponding times more water according to the maximum water absorption rate; then decocted for 3 times, wherein the first and second decoctions are 1h each, and the third decoction is 0.5h; the filtrates are filtered through a 200-mesh sieve and the filtrates are combined; a certain amount of the filtrate is taken, evaporated in a water bath to obtain an extract, the extract rate is calculated, and the optimal soaking time is determined based on the production cost.

[0017] As a further solution of the present invention: in the step S1, the number of decoctions is investigated based on the paste yield index under the condition that the Chinese medicinal materials meet the water absorption rate and the optimal soaking time, and the determination method is as follows:

[0018] The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cassia twig, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Schizonepeta tenuifolia are mixed in a mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 9 times the amount of water for a corresponding period of time, wherein the first soaking is accompanied by adding corresponding times of water according to the maximum water absorption rate, and then decocted for 1, 2 and 3 times, each time for 1 hour, and filtered through a 200-mesh sieve, and the filtrate is combined; a certain amount of the filtrate is taken, evaporated in a water bath to obtain an extract, the extract rate is calculated, and the optimal decoction number is determined.

[0019] As a further solution of the present invention: in the step S1, the amount of water added is investigated based on the paste yield index under the condition that the Chinese medicinal materials meet the water absorption rate, the optimal soaking time and the number of decoctions. The determination method is as follows:

[0020] The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cinnamomum cassia, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Schizonepeta tenuifolia are mixed in a mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 7 times, 9 times and 11 times the amount of water for corresponding time, respectively; during the first soaking, more water is added according to the maximum water absorption rate; the mixture is decocted for corresponding times and time, filtered through a 200-mesh sieve, and the filtrate is combined; a certain amount of the filtrate is taken, evaporated in a water bath to obtain an extract; the extract ratio is calculated and the optimal amount of water is determined.

[0021] As a further solution of the present invention: in the step S1, the decoction time is investigated based on the paste yield index under the conditions that the Chinese medicinal materials meet the water absorption rate and the optimal soaking time, decoction times and water addition amount, and the determination method is as follows:

[0022] The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cinnamomum cassia, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Schizonepeta tenuifolia are mixed in a mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 11 times the amount of water for a corresponding time, wherein a corresponding amount of water is added during the first soaking according to the maximum water absorption rate; decocted for a corresponding number of times, each time for 0.5 h, 1 h and 1.5 h respectively, filtered through a 200-mesh sieve, and the filtrate was combined; a certain amount of the filtrate was taken, evaporated in a water bath to obtain an extract; the extract rate was calculated, and the optimal decoction time was determined in combination with the production cost.

[0023] Among the components of Chinese medicinal materials, their picking, processing, nature and taste, meridians, functions and indications are as follows:

[0024] Angelica: Dig up in late autumn, remove the fibrous roots and sand, wait for the water to evaporate slightly, tie into small bundles, put them on the shed, and slowly smoke dry with fireworks; Its nature and meridians: sweet, spicy, warm; enter the liver, heart, and spleen meridians; Functions and indications: nourish blood, promote blood circulation, regulate menstruation and relieve pain;

[0025] Uncaria rhynchophylla: harvested in autumn and winter, defoliated, cut into sections, and sun-dried; its nature and flavor and meridians: sweet, cool; enters the liver and pericardium meridians; functions and indications: clears heat and soothes the liver;

[0026] Astragalus: dug in spring and autumn, remove the fibrous roots and root heads, and dry in the sun; its nature and flavor and meridians: sweet, slightly warm; enters the spleen and lung meridians; functions and indications: replenish qi and raise yang;

[0027] Cinnamon twig: harvested in spring and summer, leaves removed, sun-dried, or sliced ​​and sun-dried; its nature and meridians: pungent, sweet, warm; enters the heart, lung, and bladder meridians; functions and indications: warms and dredges the meridians, helps yang and transforms qi, and balances and descends qi;

[0028] Senecio: can be harvested in all seasons, remove impurities and dry in the shade; its nature and flavor and meridians: cold in nature, bitter in taste; enters the lung and liver meridians; function and indications: diuretic;

[0029] Motherwort: Fresh products are harvested from the seedling stage in spring to the pre-flowering stage in early summer; dried products are harvested in summer when the stems and leaves are lush and the flowers have not yet bloomed or have just bloomed, and then sun-dried or cut into sections and sun-dried; its nature and flavor and meridians: bitter and pungent, and it enters the liver, pericardium, and bladder meridians; functions and indications: promoting blood circulation and regulating menstruation;

[0030] Artemisia annua: harvested in autumn when the flowers are in full bloom, old stems removed, and dried in the shade; its nature and meridians: bitter and pungent, cold in nature, enters the liver and gallbladder meridians; functions and indications: cooling blood and stopping bleeding;

[0031] Mugwort: Pick it in summer before the flowers bloom, remove impurities, and dry it in the sun; its nature and meridians: pungent, bitter, warm; it enters the liver, spleen, and kidney meridians; functions and indications: warming the meridians to stop bleeding, dispelling cold and relieving pain, regulating menstruation and stabilizing pregnancy;

[0032] Schizonepeta: harvested in summer and autumn when the flowers have reached the top and the spikes are green, remove impurities, and dry in the sun; its nature and flavor and meridians: pungent, slightly warm; enters the lung and liver meridians; functions and indications: relieves exterior symptoms and dispels wind;

[0033] Huangjingzi: harvested from September to October, dried; its nature and flavor and meridians: pungent, bitter, warm, enters the lung, stomach, and liver meridians; functions and indications: dispel wind and relieve exterior symptoms, relieve cough and asthma, regulate qi, promote digestion, and relieve pain;

[0034] Malan: harvested in summer and autumn, removed from impurities, and dried in the sun; its nature and flavor and meridians: spicy, cool; meridians of the lung, liver, stomach, and large intestine; functions and indications: cooling blood and stopping bleeding, clearing heat and removing dampness;

[0035] Lemongrass: can be harvested in all seasons, washed, used fresh or dried; its nature and flavor and meridians: warm in nature, pungent in taste, enters the lung, bladder, and stomach meridians; functions and indications: aromatic, has the effects of dispelling wind and unblocking meridians, warming the middle, stopping diarrhea, and relieving pain;

[0036] The method for using the Yaoyu effervescent ball prepared by the invention is as follows: take 1 to 2 effervescent balls each time for bathing, place them in water, and adjust the water temperature according to the heat resistance habit of the user, preferably at 38 to 42°C.

[0037] Compared with the prior art, the present invention has the following beneficial effects:

[0038] The invention prepares a Yaoyu effervescent ball by using Chinese medicinal materials including angelica, Uncaria rhynchophylla, astragalus, vitex negundo, cassia twig, motherwort, senecio, amaranth, artemisia annua, wormwood, citronella and schizonepeta, and adding auxiliary materials; the Yaoyu effervescent ball has the health care effects of invigorating qi and blood and regulating Chong and Ren meridians; and has the health care effect of promoting recovery for parturients suffering from fatigue, weakness, soreness of waist and knees, damp-heat and persistent lochia caused by qi and blood imbalance. DETAILED DESCRIPTION

[0039] Example 1

[0040] In an embodiment of the present invention, a Yaoyu effervescent ball for parturients is prepared from Chinese medicinal materials and auxiliary materials, wherein the Chinese medicinal materials are composed of the following components by weight: 4 parts of angelica, 8 parts of Uncaria rhynchophylla, 8 parts of Astragalus, 8 parts of Vitex negundo, 8 parts of cinnamon twig, 12 parts of Leonurus japonicus, 8 parts of Senecio lancea, 4 parts of Amaranthus annuus, 8 parts of Artemisia annua, 4 parts of Artemisia argyi, 4 parts of Cyperus rotundus, and 4 parts of Nepeta tenuifolia;

[0041] The auxiliary materials are composed of 8 parts of soluble starch, 2 parts of polyvinyl pyrrolidone, 35 parts of citric acid, 35 parts of anhydrous sodium carbonate, and 2 parts of sodium benzoate.

[0042] Example 2

[0043] In an embodiment of the present invention, a Yaoyu effervescent ball for parturients is prepared from Chinese medicinal materials and auxiliary materials, and the Chinese medicinal materials are composed of the following by mass: 5 parts of angelica, 10 parts of Uncaria rhynchophylla, 10 parts of Astragalus, 10 parts of Vitex negundo, 10 parts of cinnamon twig, 15 parts of Leonurus japonicus, 10 parts of Senecio scabra, 5 parts of Amaranthus chinensis, 10 parts of Artemisia annua, 5 parts of Artemisia argyi, 10 parts of Cyperus rotundus, and 10 parts of Nepeta tenuifolia;

[0044] The auxiliary materials are composed of the following by mass: 10 parts of soluble starch, 2.5 parts of polyvinyl pyrrolidone, 37.5 parts of citric acid, 37.5 parts of anhydrous sodium carbonate, and 2.5 parts of sodium benzoate.

[0045] Example 3

[0046] In an embodiment of the present invention, a Yaoyu effervescent ball for parturients is prepared from Chinese medicinal materials and auxiliary materials, wherein the Chinese medicinal materials are composed of the following components by weight: 6 parts of angelica, 12 parts of Uncaria rhynchophylla, 12 parts of Astragalus, 12 parts of Vitex negundo, 12 parts of cinnamon twig, 18 parts of Leonurus japonicus, 12 parts of Senecio strychnos, 6 parts of Amaranthus chinensis, 12 parts of Artemisia annua, 6 parts of Artemisia argyi, 6 parts of Cyperus rotundus, and 6 parts of Nepeta tenuifolia;

[0047] The auxiliary materials are composed of the following by mass: 12 parts of soluble starch, 3 parts of polyvinyl pyrrolidone, 40 parts of citric acid, 40 parts of anhydrous sodium carbonate, and 3 parts of sodium benzoate.

[0048] In Example 1, Example 2 and Example 3, the process optimization steps in step S1 are as follows:

[0049] S11, 5g of Chinese angelica, 10g of Uncaria rhynchophylla, 10g of Astragalus, 10g of Nepenthes, 10g of Cinnamomum cassia, 15g of Leonurus japonicus, 10g of Senecio grandiflora, 5g of Amaranthus malachus, 10g of Artemisia annua, 5g of Artemisia argyi, 5g of Cymbopogon citratus and 5g of Nepeta tenuifolia were mixed, and then soaked in 9 times the weight of water until the weight of the medicinal materials no longer increased, and the water absorption rate was measured at 0h, 1h, 2h, 4h and 6h to determine the maximum water absorption rate of the medicinal materials; the measured water absorption rates are shown in Table 1 below;

[0050] Table 1 Analysis of water absorption rate of medicinal materials

[0051] Serial number Soaking time (h) Weight after water absorption (g) Water absorption (%) 1 0.0 100 0 2 2.0 260.68 160.48 3 4.0 266.41 166.21 4 6.0 268.31 168.10

[0052] From Table 1 above, we can conclude that the maximum water absorption rate of medicinal materials is 168.10%. For the convenience of operation, the water absorption rate is calculated as 168%, that is, the maximum water absorption of medicinal materials is 1.5 times the weight of medicinal materials;

[0053] S12, 5g of Angelica sinensis, 10g of Uncaria rhynchophylla, 10g of Astragalus membranaceus, 10g of Vitex negundo, 10g of Cinnamomum cassia, 15g of Leonurus japonicus, 10g of Senecio grandiflora, 5g of Amaranthus australis, 10g of Artemisia annua, 5g of Artemisia argyi, 5g of Cymbopogon citratus and 5g of Nepeta tenuifolia were mixed, and then soaked in 9 times of water for 0h, 0.5h, 1h, 3h and 5h respectively, wherein 1.5 times of water was added for the first soaking; then decocted 3 times, the first and second decoctions were decocted for 1h each, and the third decoction was decocted for 0.5h, and the filtrate was combined after filtering with a 200-mesh sieve; 50ml of the filtrate was taken, and evaporated in a water bath to obtain an extract; the extract was dried at 105°C to constant weight, placed in a dryer for 0.5h, and weighed, and 3 data in each group were averaged, as shown in Table 2 for details, and analysis of variance is shown in Table 3;

[0054] Table 2 Soaking time analysis table

[0055]

[0056] In Table 2 above, the paste yield (%) = {total weight of dry paste (g) / amount of material added (g)}×100%.

[0057] Table 3 One-way ANOVA table of soaking time

[0058] Source of Difference SS df MS F P-value Between groups 3.786 4 0.946 130.959 0.000 Within group 0.072 10 0.007 total 3.858 14

[0059] In Table 3 above, SS stands for the sum of squares of deviations from the mean, representing the total variation of the data; F stands for the F value, which is the statistic obtained by variance analysis and is used to test whether the regression equation is significant; df stands for degrees of freedom, which is the number of variables with unrestricted values ​​when calculating a certain statistic; MS stands for mean square, and its value is equal to the corresponding SS / DF; P-value stands for the probability value under the corresponding F value;

[0060] From Table 2 and Table 3 above, we can conclude that: the single factor investigation result analysis of soaking time: P < 0.01, indicating that different soaking times have significant differences, but because the extracting rate of the cream after soaking for 3 hours only accounts for 3.28% of the total extracting rate, for cost saving considerations, the optimal soaking time is determined to be 1 hour;

[0061] S13, 5g of Angelica sinensis, 10g of Uncaria rhynchophylla, 10g of Astragalus membranaceus, 10g of Vitex negundo, 10g of Cinnamomum cassia, 15g of Leonurus japonicus, 10g of Senecio grandiflora, 5g of Amaranthus chinensis, 10g of Artemisia annua, 5g of Artemisia argyi, 5g of Cymbopogon citratus and 5g of Nepeta tenuifolia were mixed, and the mixture was soaked in 9 times the amount of water for 1 hour, wherein 1.5 times the amount of water was added during the first soaking; the mixture was decocted for 1, 2 and 3 times, each time for 1 hour, filtered through a 200 mesh sieve, and the filtrate was combined; 50ml of the filtrate was taken, and evaporated in a water bath to obtain an extract; the extract was dried at 105°C to constant weight, placed in a desiccator for 0.5h, and then weighed, and 3 data were obtained for each group, and the average value was taken, as shown in Table 4 for details, and the variance analysis is shown in Table 5;

[0062] Table 4 Analysis of decoction times

[0063]

[0064] Table 5 One-way ANOVA table of decoction times

[0065] Source of Difference SS df MS F P-value Between groups 51.139 2 25.569 3741.365 0.000 Within group 0.041 6 0.007 total 51.180 8

[0066] From Table 4 and Table 5 above, we can conclude that: the univariate analysis of the number of decoctions: P < 0.01, indicating that there are significant differences in the number of decoctions, and the highest paste yield is obtained after 3 decoctions, and the optimal number of decoctions is determined to be 3 times;

[0067] S14, 5g of Angelica sinensis, 10g of Uncaria rhynchophylla, 10g of Astragalus membranaceus, 10g of Vitex negundo, 10g of Cinnamomum cassiae, 15g of Leonurus japonicus, 10g of Senecio grandiflora, 5g of Amaranthus amaranthus, 10g of Artemisia annua, 5g of Artemisia argyi, 5g of Cymbopogon citratus and 5g of Nepeta tenuifolia were mixed, and the mixture was soaked in 7 times, 9 times and 11 times of water for 1 hour respectively, wherein 1.5 times of water was added for the first soaking; the mixture was decocted for 3 times accordingly, the first and second decoctions were decocted for 1 hour each, and the third decoction was decocted for 0.5 hour, and the filtrate was combined after filtering through a 200 mesh sieve; 50ml of the filtrate was taken, and evaporated in a water bath to obtain an extract; the extract was dried at 105°C to constant weight, placed in a desiccator for 0.5 hour, and then weighed. There were 3 data in each group, and the average value was taken. The details are shown in Table 6, and the variance analysis is shown in Table 7;

[0068] Table 6 Water addition analysis table

[0069]

[0070]

[0071] Table 7 Single factor analysis of variance of water addition

[0072] Source of Difference SS df MS F P-value Between groups 4.839 2 2.42 310.414 0.000 Within group 0.047 6 0.008 total 4.886 8

[0073] From Table 4 and Table 5 above, it can be concluded that: the single factor investigation result analysis of the amount of water added: P < 0.01, indicating that there are significant differences in different amounts of water added, and the optimal amount of water added is determined to be 11 times that of Chinese medicinal materials.

[0074] S15, 5g of Angelica sinensis, 10g of Uncaria rhynchophylla, 10g of Astragalus membranaceus, 10g of Vitex negundo, 10g of Cinnamomum cassia, 15g of Leonurus japonicus, 10g of Senecio grandiflora, 5g of Amaranthus amaranthus, 10g of Artemisia annua, 5g of Artemisia argyi, 5g of Cymbopogon citratus and 5g of Nepeta tenuifolia were mixed, and the mixture was soaked in 11 times the amount of water for 1 hour, wherein 1.5 times the amount of water was added during the first soaking; the mixture was decocted for 3 times, each time for 0.5h, 1h and 1.5h respectively, and the filtrate was combined after filtering with a 200-mesh sieve; 50ml of the filtrate was evaporated in a water bath to obtain an extract; the extract was dried at 105°C to constant weight, placed in a desiccator for 0.5h, and weighed, and 3 data were obtained in each group, and the average value was taken, as shown in Table 8 for details, and the variance analysis is shown in Table 9;

[0075] Table 8 Decoction time analysis table

[0076]

[0077]

[0078] Table 9 One-way ANOVA of decoction time

[0079] Source of Difference SS df MS F P-value Between groups 1.956 2 0.978 277.726 0.000 Within group 0.021 6 0.004 total 1.978 8

[0080] From Table 8 and Table 9 above, we can conclude that: the single factor analysis of decoction time: P < 0.01, indicating that there are significant differences in different decoction times, but because the extract yield of 1.5h only accounts for 5.19% of the total extract yield, for cost saving considerations, the optimal decoction time is determined to be 1.0h;

[0081] Furthermore, it can be concluded that: taking the paste yield as an indicator and comprehensive cost considerations, the optimal extraction process is determined to be: 11 times the amount of water, soaking for 1 hour, decocting 3 times, of which 1.5 times more water is added for the first time, the first decoction is 1 hour, the second decoction is 1 hour, and the third decoction is 1 hour; take Chinese medicinal materials, repeat the optimal extraction process three times, and compare the paste yield. The results are shown in Table 10.

[0082] Table 10 Process stability verification analysis table

[0083]

[0084] It can be concluded from Table 10 above that after three batches of process verification, the paste yield was 18.82%, RSD = 0.44%, indicating that the process is stable and feasible.

[0085] In Example 1, a preparation process of a Yaoyu effervescent ball for parturients comprises the following steps:

[0086] S1. Process optimization: as above;

[0087] S2, filtrate preparation: according to the mass parts, take 4 parts of angelica, 8 parts of Uncaria rhynchophylla, 8 parts of Astragalus, 8 parts of Vitex negundo, 8 parts of cinnamon twig, 12 parts of Leonurus japonicus, 8 parts of Senecio grandiflora, 4 parts of Amaranthus amaranthus, 8 parts of Artemisia annua, 4 parts of Artemisia argyi, 4 parts of Cymbopogon citratus, 4 parts of Nepeta tenuifolia, add 11 times the mass of water to soak for 1 hour, then decoct for 1 hour, filter with a 200-mesh sieve to obtain a filtrate and a medicinal residue; then add 10 times the mass of water to the medicinal residue, decoct again for 1 hour, filter with a 200-mesh sieve, obtain a filtrate and a medicinal residue again, repeat 2 times to obtain a filtrate and a medicinal residue;

[0088] S3, preparation of extract powder: after combining all the filtrates, heat and reduce pressure to concentrate to a relative density of 1.12 to obtain a clear paste, and spray dry it at 150° C. using a peristaltic pump to obtain an extract powder;

[0089] S4. Preparation of effervescent balls: Take 8 parts of soluble starch, 2 parts of polyvinyl pyrrolidone, 35 parts of citric acid, 35 parts of anhydrous sodium carbonate, and 2 parts of sodium benzoate by mass, spray-dry them at 150° C. using a peristaltic pump, add them to the extract powder, mix and stir evenly; press them into effervescent balls each weighing 100 g, and put them into storage after packaging and inspection.

[0090] In Example 2, a preparation process of a Yaoyu effervescent ball for parturients comprises the following steps:

[0091] S1. Process optimization: as above;

[0092] S2, filtrate preparation: according to the mass parts, take 5 parts of angelica, 10 parts of Uncaria rhynchophylla, 10 parts of Astragalus, 10 parts of Vitex negundo, 10 parts of cinnamon twig, 15 parts of Leonurus japonicus, 10 parts of Senecio grandiflora, 5 parts of Amaranthus amaranthus, 10 parts of Artemisia annua, 5 parts of Artemisia argyi, 10 parts of Cymbopogon citratus, and 10 parts of Nepeta tenuifolia, add 11 times the mass of water to soak for 1 hour, then decoct for 1 hour, filter with a 200-mesh sieve to obtain a filtrate and a medicinal residue; then add 10 times the mass of water to the medicinal residue, decoct again for 1 hour, filter with a 200-mesh sieve, obtain a filtrate and a medicinal residue again, repeat 2 times to obtain a filtrate and a medicinal residue;

[0093] S3. Preparation of extract powder: After combining all the filtrates, heat and reduce pressure to concentrate to a relative density of 1.14 to obtain a clear paste, and spray dry it at 150° C. using a peristaltic pump to obtain an extract powder;

[0094] S4. Preparation of effervescent balls: Take 10 parts of soluble starch, 2.5 parts of polyvinyl pyrrolidone, 37.5 parts of citric acid, 37.5 parts of anhydrous sodium carbonate, and 2.5 parts of sodium benzoate by mass, spray-dry them at 150°C using a peristaltic pump, add them to the extract powder, mix and stir evenly; press them into effervescent balls each weighing 100g, and put them into storage after packaging and inspection.

[0095] In Example 3, a preparation process of a Yaoyu effervescent ball for parturients comprises the following steps:

[0096] S1. Process optimization: as above;

[0097] S2, filtrate preparation: according to the mass parts, take 6 parts of angelica, 12 parts of Uncaria rhynchophylla, 12 parts of Astragalus, 12 parts of Vitex negundo, 12 parts of cinnamon twig, 18 parts of Leonurus japonicus, 12 parts of Senecio grandiflora, 6 parts of Amaranthus amaranthus, 12 parts of Artemisia annua, 6 parts of Artemisia argyi, 6 parts of Cymbopogon citratus, 6 parts of Nepeta tenuifolia, add 11 times the mass of water to soak for 1 hour, then decoct for 1 hour, filter with a 200-mesh sieve to obtain a filtrate and a medicinal residue; then add 10 times the mass of water to the medicinal residue, decoct again for 1 hour, filter with a 200-mesh sieve, obtain a filtrate and a medicinal residue again, repeat 2 times to obtain a filtrate and a medicinal residue;

[0098] S3, preparation of extract powder: after combining all the filtrates, heat and reduce pressure to concentrate to a relative density of 1.16 to obtain a clear paste, and spray dry it at 150° C. using a peristaltic pump to obtain an extract powder;

[0099] S4. Preparation of effervescent balls: Take 12 parts of soluble starch, 3 parts of polyvinyl pyrrolidone, 40 parts of citric acid, 40 parts of anhydrous sodium carbonate, and 3 parts of sodium benzoate according to mass parts, spray-dry them at 150°C using a peristaltic pump, add them to the extract powder, mix and stir evenly; press them into effervescent balls each weighing 100g, and put them into storage after packaging and inspection.

[0100] In order to better illustrate the technical effects of the present invention, the following embodiments are described:

[0101] The effervescent balls prepared in Examples 1 to 3 of the present invention were subjected to acute oral toxicity tests and multiple intact skin irritation tests, as follows:

[0102] 1. Materials and Animals

[0103] 1. Sample: The effervescent ball prepared in Examples 1 to 3 of the present invention, wherein the sample in the oral toxicity test is prepared with deionized water and then tested; and the sample in the multiple skin prick test is moistened with deionized water and then applied for administration.

[0104] 2. Experimental animals: 10 SPF-grade SD rats per group, half male and half female, weighing 180-220 g; 4 New Zealand white rabbits per group, weighing 2.0-3.0 kg, all provided by the Experimental Animal Center of Guizhou Medical University, Animal Production License No.: SCXK(Gui)2023-0002.

[0105] 3. Breeding environment: SPF-level animal room of the Toxicity Testing Center of Guizhou Medical University, use license number: SYXK(Guizhou)2021-0007; rat feed and rabbit feed are provided by Beijing Keao Xieli Feed Co., Ltd., production license number: SCXK(Beijing)2019-0003; bedding is provided by Beijing Keao Xieli Feed Co., Ltd., production license number: SCXK(Beijing)2020-0010.

[0106] 2. Methods: Based on the 2015 edition of the "Technical Specifications for Safety of Cosmetics" issued by the State Food and Drug Administration, Chapter 6 Toxicology Test Methods (2. Acute oral toxicity test; 4. Skin irritation / corrosion test).

[0107] (1) The results of the acute oral toxicity test are recorded in Table 11 below;

[0108] Table 11 Results of acute oral toxicity test in rats

[0109]

[0110]

[0111] It can be concluded from Table 11 that in Examples 1 to 3, the rats showed no symptoms of poisoning after being exposed to the poison, no deaths occurred during the observation period, and no obvious abnormalities were found in the gross autopsy of the animals.

[0112] (2) During the multiple intact skin irritation tests, the rabbits were given the drug once a day for 14 consecutive days, and the local skin reactions of the animals were observed 24 hours after each administration; and the results were recorded in Table 12 below;

[0113] Table 12 Results of multiple intact skin irritation tests on rabbits

[0114]

[0115]

[0116] It can be concluded from Table 12 above that no abnormality was found in the skin of any rabbit.

[0117] It was concluded that according to the acute oral toxicity classification standard of the "Safety Technical Specifications for Cosmetics" (2015 edition), the acute oral LD50 of Congjiang postpartum Yaoyu soaking rattan ball in rats was 50The acute oral toxicity of both female and male rats is >5000 mg / kg, and the acute oral toxicity of both female and male rats is practically non-toxic. According to the skin irritation scoring standard of the "Technical Specification for Safety of Cosmetics" (2015 edition), the present invention has been applied to the intact skin of New Zealand white rabbits for multiple times, and the average integral value is 0, the skin irritation index is 0-<0.5, and the skin irritation intensity is non-irritating.

[0118] What is described above is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A Yaoyu effervescent ball for parturients, prepared from Chinese medicinal materials and auxiliary materials, characterized in that: The Chinese medicinal materials are composed of the following by weight: 4-6 parts of Chinese Angelica, 8-12 parts of Uncaria rhynchophylla, 8-12 parts of Astragalus, 8-12 parts of Vitex negundo, 8-12 parts of Cinnamomum cassia, 12-18 parts of Leonurus japonicus, 8-12 parts of Senecio truncatum, 4-6 parts of Amaranthus chinensis, 8-12 parts of Artemisia annua, 4-6 parts of Artemisia argyi, 4-6 parts of Cymbopogon citratus and 4-6 parts of Nepeta tenuifolia; The auxiliary materials are composed of the following by weight: 8 to 12 parts of soluble starch, 2 to 3 parts of polyvinyl pyrrolidone, 35 to 40 parts of citric acid, 35 to 40 parts of anhydrous sodium carbonate and 2 to 3 parts of sodium benzoate.

2. A process for preparing the Yaoyu effervescent ball for parturients according to claim 1, characterized in that: The following steps are involved: S1. Process optimization: Mix the Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cinnamomum cassia, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Nepeta tenuifolia in the mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), soak them in water and measure the water absorption rate; and under the condition of meeting the water absorption rate, take the paste yield of Chinese medicinal materials as an indicator and combine the production cost; determine the optimal amount of water added, soaking time, decoction time and decoction times of Chinese medicinal materials; S2, filtrate preparation: take 4-6 parts of angelica, 8-12 parts of Uncaria rhynchophylla, 8-12 parts of Astragalus, 8-12 parts of Vitex negundo, 8-12 parts of cinnamon twig, 12-18 parts of Leonurus japonicus, 8-12 parts of Senecio radix, 4-6 parts of Amaranthus chinensis, 8-12 parts of Artemisia annua, 4-6 parts of Artemisia argyi, 4-6 parts of Cymbopogon citratus, 4-6 parts of Nepeta tenuifolia according to the mass parts, and soak, decoct and filter according to the determined amount of water added, soaking time, number of decoctions and decoction time, to obtain a filtrate and a medicinal residue; S3, preparation of extract powder: after combining all the filtrates, heat and reduce pressure to concentrate to a relative density of 1.12 to 1.16 to obtain a clear paste, and spray dry it at 150° C. using a peristaltic pump to obtain an extract powder; S4. Preparation of effervescent balls: Take 8-12 parts of soluble starch, 2-3 parts of polyvinyl pyrrolidone, 35-40 parts of citric acid, 35-40 parts of anhydrous sodium carbonate, and 2-3 parts of sodium benzoate by mass, spray-dry them at 150°C using a peristaltic pump, add them to the extract powder, mix and stir evenly; press them into effervescent balls of a set size; and put them into storage after packaging and inspection.

3. The preparation process of the Yaoyu effervescent ball for parturients according to claim 2, characterized in that: In the step S1, the method for determining the water absorption rate of the medicinal material is as follows: The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cassia twig, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Schizonepeta tenuifolia were mixed in the mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 9 times the weight of water until the weight of the medicinal materials no longer increases. The water absorption rate was measured at 0h, 1h, 2h, 4h and 6h respectively to determine the maximum water absorption rate of the medicinal materials.

4. The preparation process of the Yaoyu effervescent ball for parturients according to claim 3, characterized in that: In the step S1, the soaking time is investigated based on the paste yield index under the condition that the Chinese medicinal materials meet the water absorption rate, and the determination method is as follows: The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cinnamomum cassia, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Nepeta tenuifolia are mixed in a mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 9 times the weight of water for 0h, 0.5h, 1h, 3h and 5h, respectively, wherein the first soaking is added with corresponding times more water according to the maximum water absorption rate; then decocted for 3 times, wherein the first and second decoctions are 1h each, and the third decoction is 0.5h; the filtrates are filtered through a 200-mesh sieve and the filtrates are combined; a certain amount of the filtrate is taken, evaporated in a water bath to obtain an extract, the extract rate is calculated, and the optimal soaking time is determined based on the production cost.

5. The preparation process of the Yaoyu effervescent ball for parturients according to claim 4, characterized in that: In the step S1, the number of decoctions is determined by the paste yield index under the condition that the Chinese medicinal materials meet the water absorption rate and the optimal soaking time. The determination method is as follows: The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cassia twig, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Schizonepeta tenuifolia are mixed in a mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 9 times the amount of water for a corresponding period of time, wherein the first soaking is accompanied by adding corresponding times of water according to the maximum water absorption rate, and then decocted for 1, 2 and 3 times, each time for 1 hour, and filtered through a 200-mesh sieve, and the filtrate is combined; a certain amount of the filtrate is taken, evaporated in a water bath to obtain an extract, the extract rate is calculated, and the optimal decoction number is determined.

6. The preparation process of the Yaoyu effervescent ball for parturients according to claim 5, characterized in that: In the step S1, the amount of water added is investigated based on the paste yield index under the condition that the Chinese medicinal materials meet the water absorption rate, the optimal soaking time and the number of decoctions. The determination method is as follows: The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cinnamomum cassia, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Schizonepeta tenuifolia are mixed in a mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 7 times, 9 times and 11 times the amount of water for corresponding time, respectively; during the first soaking, more water is added according to the maximum water absorption rate; the mixture is decocted for corresponding times and time, filtered through a 200-mesh sieve, and the filtrate is combined; a certain amount of the filtrate is taken, evaporated in a water bath to obtain an extract; the extract ratio is calculated and the optimal amount of water is determined.

7. The preparation process of the Yaoyu effervescent ball for parturients according to claim 6, characterized in that: In the step S1, the decoction time is investigated based on the paste yield index under the conditions that the Chinese medicinal materials meet the water absorption rate and the optimal soaking time, decoction times and water addition amount. The determination method is as follows: The Chinese medicinal materials Angelica sinensis, Uncaria rhynchophylla, Astragalus membranaceus, Vitex negundo, Cinnamomum cassia, Leonurus japonicus, Senecio grandiflora, Amaranthus annua, Artemisia annua, Artemisia argyi, Cymbopogon citratus and Schizonepeta tenuifolia are mixed in a mass ratio of (4-6):(8-12):(8-12):(8-12):(8-12):(12-18):(8-12):(4-6):(8-12):(4-6):(4-6):(4-6), and then soaked in 11 times the amount of water for a corresponding time, wherein a corresponding amount of water is added during the first soaking according to the maximum water absorption rate; decocted for a corresponding number of times, each time for 0.5 h, 1 h and 1.5 h respectively, filtered through a 200-mesh sieve, and the filtrate was combined; a certain amount of the filtrate was taken, evaporated in a water bath to obtain an extract; the extract rate was calculated, and the optimal decoction time was determined in combination with the production cost.

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