Partially absorbable intelligent hernia repair net and preparation method thereof

Abstract

The invention relates to a partially absorbable intelligent hernia repair net and a preparation method thereof, and belongs to the technical field of textile materials. The partially absorbable intelligent hernia repair net comprises monofilament units, an antibacterial unit and a monitoring unit, the monofilament units can be partially absorbed by a human body, the multiple monofilament units are connected to form a hernia repair net body, at least part of the antibacterial unit is formed on the surfaces of the monofilament units, and the monitoring unit is connected with the hernia repair net body. The monitoring unit monitors the strain and position of the hernia repair net. According to the hernia repair net, the pain of a patient after hernia repair can be greatly relieved, the hospitalization time and the rehabilitation cycle of the patient can be shortened, the position of the hernia repair net can be monitored in real time, the recurrence risk of hernia repair is reduced, and the life quality of the patient after hernia repair is improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and specifically relates to a partially absorbable intelligent hernia repair mesh and a preparation method thereof. Background Art

[0002] In the medical field, hernia repair surgery is an important means of treating defects in the abdominal wall or other parts. Traditional hernia repair surgery repairs the hernia ring by directly suturing the tissues around the defect. Traditional hernia repair surgery has many disadvantages: first, patients often experience more severe pain symptoms after surgery. This pain may be persistent or aggravated during activities, greatly affecting the patient's daily activities and rest; second, swelling is also common, which not only increases the patient's discomfort, but also may cause local blood circulation disorders, slow down the healing of wounds, and abdominal discomfort also occurs from time to time. For example, patients may feel a sense of heaviness or pulling in the abdomen, which will have a negative impact on the patient's psychology over a long period of time.

[0003] In recent years, although tension-free herniorrhaphy using hernia patches has great technical advantages, it is difficult to implement technically. The success of tension-free herniorrhaphy depends largely on the selection and design of the repair material. Traditional hernia repair often uses synthetic materials such as polypropylene and polyester. Although they have good mechanical strength and can maintain the effect of hernia repair for a certain period of time, long-term implantation will cause a series of serious complications. The human immune system will identify these implanted materials as foreign bodies, thereby initiating an immune response, leading to local inflammation and aggravating the patient's pain. Once an infection occurs, not only additional anti-infection treatment is required, but a second operation may even be required to remove the patch. In addition, these repair materials may adhere to the surrounding tissues, which will affect the patient's normal physiological structure and body function. For example, intestinal adhesion may lead to serious consequences such as intestinal obstruction, greatly affecting the patient's quality of life.

[0004] With the continuous advancement of medical technology, the requirements for material selection and design are becoming increasingly stringent. They need to meet multiple characteristics such as biocompatibility, mechanical properties and absorbability at the same time, which increases the difficulty of material selection and design. However, with the cross-integration of materials science, nanotechnology, biomedical engineering and information technology, the design concept and preparation technology of hernia repair materials have undergone revolutionary changes. The technical problems left over from traditional materials are still the focus of attention and need to be solved in the current hernia repair field. Summary of the invention

[0005] The present invention proposes a partially absorbable intelligent hernia repair mesh and a preparation method thereof, aiming to partially or completely solve the technical problems of biocompatibility, mechanical properties and absorbability of hernia repair materials in the prior art. The absorbable intelligent hernia repair mesh has intelligent wireless sensor monitoring function and partially absorbable characteristics, and has good biocompatibility, antibacterial and mechanical properties. The warp knitting technology is used to ensure its air permeability and stability, which reduces the recurrence rate of patients and brings patients a more comfortable and healthy rehabilitation experience. The technical solution of the present invention is as follows:

[0006] In a first aspect, a partially absorbable intelligent hernia repair mesh includes: a monofilament unit, an antibacterial unit and a monitoring unit, wherein a portion of the monofilament unit is absorbable into the human body, a plurality of monofilament units are connected to form a hernia repair mesh body, the antibacterial unit is at least partially formed on the surface of the monofilament unit, the monitoring unit is connected to the hernia repair mesh body, and the monitoring unit monitors the strain and position of the hernia repair mesh.

[0007] Optionally, the monofilament unit includes a skeleton portion and a main body portion, the skeleton portion can be absorbed by the human body, the cross-section of the skeleton portion is circular, cross-shaped or cross-shaped, the raw material of the main body portion includes but is not limited to polypropylene and polyethylene, and the raw material of the skeleton portion includes but is not limited to polylactic acid, polycaprolactone, polyglycolide, and polycaprolactone-polyglycolide copolymer.

[0008] Optionally, the antibacterial unit comprises antibacterial nanoparticles, which include but are not limited to silver nanoparticles, copper nanoparticles, and zinc oxide nanoparticles.

[0009] Optionally, the monitoring unit includes a sensor, a connecting part and a wireless communication part, the sensor is connected to the single-filament unit and the connecting part, the connecting part is connected to the wireless communication part, and the connecting part includes but is not limited to gold wire and silver paste.

[0010] In a second aspect, a method for preparing a partially absorbable intelligent hernia repair mesh, comprising the following steps:

[0011] Step S100: obtaining a monofilament unit;

[0012] Step S200: the antibacterial unit is at least partially formed on the surface of the monofilament unit;

[0013] Step S300: a plurality of antibacterial monofilament units are connected to form a hernia repair mesh body, and a monitoring unit is connected to the hernia repair mesh body.

[0014] Optionally, step S100 includes: the main body is made of polypropylene injection molding pellets, the skeleton is made of polyglycolide injection molding pellets, the skeleton has a cross-section in the shape of a cross-section, the mass fraction of polyglycolide is 60%, and the mass fraction of polypropylene is 40%.

[0015] Optionally, step S200 includes:

[0016] Step S201: adding nanoparticles of the antibacterial unit into a solvent or a carrier;

[0017] Step S202: uniformly dispersing the antibacterial nanoparticles;

[0018] Step S203: coating the antibacterial nanoparticles on the surface of the monofilament unit;

[0019] Step S204: placing the surface of the monofilament unit coated with antibacterial nanoparticles in a dark environment for drying at room temperature to remove the solvent or carrier so that the antibacterial nanoparticles are fixed on the surface of the monofilament unit;

[0020] Step S205: performing a curing treatment on the surface of the monofilament unit to which the antibacterial particles are fixed.

[0021] Optionally, step S300 includes:

[0022] Step S301: Softening the monofilament unit with antibacterial properties. According to the design requirements of the hernia repair mesh, a double-needle-bed jacquard warp knitting machine is selected. The guide bars adopt a one-through-one-out threading method and a weft-lining guide bar is added. The hole shape of the patch is set to a hexagonal shape, and a multi-guide bar configuration is adopted;

[0023] Step S302: according to the knitting process requirements, the monofilament unit with antibacterial properties is inserted into the comb and appropriate knitting parameters are set, that is, the patch has the same density in both the longitudinal and transverse directions, which are m horizontal rows or m vertical rows per centimeter, m is a positive integer, and m is greater than or equal to 2, and the warp knitting machine is started to knit, and multiple monofilament units with antibacterial properties are woven and connected to form a hernia repair embryo net. During the weaving process, the sensor is integrated into a predetermined position of the hernia repair embryo net;

[0024] Step S303: after weaving is completed, the hernia repair mesh embryo is shaped to obtain the hernia repair mesh body;

[0025] Step S304: Connect the sensor to the connecting unit, and the connecting unit is connected to the wireless communication unit.

[0026] Optionally, in step S203, the surface of the obtained monofilament unit is pretreated by spraying, with the spray gun controlled to be 10 cm away from the monofilament unit, with an inclination angle of 90° and a spraying speed of 0.3-0.5 m / s, so that the antibacterial nanoparticles are coated on the surface of the monofilament unit.

[0027] The beneficial effects achieved by the present invention are as follows:

[0028] (1) In the present invention, partially absorbable monofilament units are used as the main material of the hernia repair mesh, which has good biocompatibility and reduces the body's rejection reaction to the hernia repair mesh. With the partial degradation of the monofilament units, the growth and repair of human tissues are promoted, and the potential risks brought by long-term retention of foreign bodies, such as infection and adhesion, are avoided, thereby improving the patient's rehabilitation quality. At the same time, during the operation, the antibacterial unit is at least partially formed on the surface of the monofilament unit. The antibacterial unit can form a protection on the surface of the monofilament unit, which can effectively reduce the risk of bacterial contamination, reduce the incidence of postoperative infection, reduce complications, and facilitate wound healing. The durability and stability of the antibacterial unit also ensure that the repair mesh can still maintain a high-efficiency antibacterial effect during long-term use, providing a strong guarantee for the patient's rehabilitation.

[0029] (2) In the present application, warp knitting technology can be used to connect multiple monofilament units to form a hernia repair mesh body, so that the hernia repair mesh body has good air permeability, excellent mechanical properties and biocompatibility, and the hernia repair mesh body can also fit closely to the tissue around the hernia ring, provide stable mechanical support, and promote the healing of human tissue; the monitoring unit can also grasp the strain and position of the hernia repair mesh after being partially absorbed by the human body in real time, bringing intelligent and precise changes to hernia repair surgery, and can timely discover potential displacement or mechanical failure problems, which is helpful to prevent hernia recurrence, ensure hernia repair effects, and improve the quality of patient rehabilitation. Therefore, through the use of the above multiple technologies, the present application improves the safety and effectiveness of hernia repair surgery as a whole, reduces the occurrence of complications after hernia repair, accelerates the patient's rehabilitation process, and also brings a more comfortable and convenient rehabilitation experience to patients, improving the quality of patient rehabilitation. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the description of the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0031] Figure 1 This is a schematic structural diagram of the single-filament unit applied for in the present invention.

[0032] Figure 2 The present invention is a schematic diagram of a process for preparing a partially absorbable intelligent hernia repair mesh.

[0033] Figure 3 This is a schematic diagram of the formation principle of the antibacterial unit of the present invention being at least partially sprayed on the surface of the monofilament unit.

[0034] Figure 4The present invention is a schematic diagram of the kinematic diagram of the padding yarn of the hernia repair mesh.

[0035] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0036] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments; based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0037] In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside" and the like indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention. "Including" can at least be understood as the meaning of only including. In order to make the purpose, technical solutions and advantages of the present invention clearer, the implementation methods of the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0038] In a first aspect, a partially absorbable intelligent hernia repair mesh includes: a monofilament unit, an antibacterial unit and a monitoring unit, wherein a portion of the monofilament unit is absorbable into the human body, a plurality of monofilament units are connected to form a hernia repair mesh body, the antibacterial unit is at least partially formed on the surface of the monofilament unit, the monitoring unit is connected to the hernia repair mesh body, and the monitoring unit monitors the strain and position of the hernia repair mesh.

[0039] In the present application, firstly, partially absorbable monofilament units are used as the main material of the hernia repair mesh, which has good biocompatibility and reduces the body's rejection reaction to the repair mesh. With the partial degradation of the monofilament units, the growth and repair of human tissues are promoted, and the potential risks brought by long-term retention of foreign bodies, such as infection, adhesion, etc., are avoided, thereby improving the patient's recovery quality. In addition, during the operation, the antibacterial unit is at least partially formed on the surface of the monofilament unit. The antibacterial unit can form a protection on the surface of the monofilament unit, which can effectively reduce the risk of bacterial contamination, reduce the incidence of postoperative infection, reduce complications, and facilitate wound healing. The durability and stability of the antibacterial unit also ensure that the repair mesh is durable in the long term. It can still maintain a high-efficiency antibacterial effect during use, providing a strong guarantee for the patient's recovery; at the same time, warp knitting technology can be used to connect multiple monofilament units to form a hernia repair mesh body, so that the hernia repair mesh body has good air permeability, excellent mechanical properties and biocompatibility, and the hernia repair mesh body can also fit closely to the tissue around the hernia ring, providing stable mechanical support and promoting the healing of human tissue; in addition, the monitoring unit can also monitor the strain and position of the hernia repair mesh after being partially absorbed by the human body in real time, bringing intelligent and precise changes to hernia repair surgery, and can timely discover potential displacement or mechanical failure problems, which is helpful to prevent hernia recurrence, ensure hernia repair effects, and improve the quality of patient recovery. Therefore, through the use of the above multiple technologies, the present invention application improves the safety and effectiveness of hernia repair surgery as a whole, reduces the occurrence of complications after hernia repair, accelerates the patient's recovery process, and improves the patient's recovery quality.

[0040] Optionally, the monofilament unit includes a skeleton portion and a main body portion, the skeleton portion can be absorbed by the human body, the cross-section of the skeleton portion is circular, cross-shaped or cross-shaped, the raw material of the main body portion includes but is not limited to polypropylene and polyethylene, and the raw material of the skeleton portion includes but is not limited to polylactic acid, polycaprolactone, polyglycolide, and polycaprolactone-polyglycolide copolymer.

[0041] In the present application, Figure 1As shown in the figure, firstly, the mass fraction ratio of the skeleton part to the main part ranges from 6 / 4 to 7 / 3, and the mass fraction ratio range includes values ​​of 6 / 4 and 7 / 3. The cross-section of the skeleton part of the monofilament unit is in various forms such as M-shaped, cross-shaped, circular, etc., which can meet the needs of different hernia repair scenarios. This diversity enables the hernia repair mesh to better adapt to the shape and size of the hernia parts of different patients, and improve the accuracy and effectiveness of the repair; in addition, the skeleton part can be absorbed by the human body, avoiding the problems of foreign body reaction and infection that may be caused by long-term retention in the body. Bioabsorbable materials such as polylactic acid and polycaprolactone are used, which gradually degrade after completing the initial support of hernia repair, reduce the long-term impact on the human body, and promote natural tissue repair; in addition, the main part adopts materials such as polypropylene and polyethylene, and the main part that cannot be absorbed into human tissue still maintains its original state, which provides sufficient mechanical strength and stability for the hernia repair mesh, ensures that it can effectively withstand external forces such as abdominal pressure during the repair process, maintain the structure of the final hernia repair piece, maintain the shape and position of the hernia repair mesh stable, and reduce the possibility of hernia recurrence. For example, when the degradation medium is PBS buffer (i.e., phosphate buffered saline), after 15 days, the degradation mass of the skeleton reaches 15%, and after 30 days, the degradation mass of the skeleton reaches 42%; when the degradation medium is NaOH, when the NaOH concentration is 2.5%, the skeleton can be completely degraded in about 15 days.

[0042] Optionally, the antibacterial unit comprises antibacterial nanoparticles, which include but are not limited to silver nanoparticles, copper nanoparticles, and zinc oxide nanoparticles.

[0043] In the present invention application, silver nanoparticles, copper nanoparticles, and zinc oxide nanoparticles all have excellent antibacterial properties. They can effectively inhibit the growth and reproduction of a variety of microorganisms such as bacteria and fungi, significantly reduce the risk of infection after hernia repair surgery, and create a favorable environment for wound healing; and, while these nanoparticles play an antibacterial role, they have relatively low toxicity to normal human tissues. During the use of the hernia repair mesh, it can play an antibacterial role locally, reduce complications caused by infection, and improve the safety and comfort of patient recovery.

[0044] Optionally, the monitoring unit includes a sensor, a connecting part and a wireless communication part, the sensor is connected to the single-filament unit and the connecting part, the connecting part is connected to the wireless communication part, and the connecting part includes but is not limited to gold wire and silver paste.

[0045] In the present application, the sensor (or sensor group) includes a strain sensor, a displacement sensor, etc. The sensor is connected to a single-filament unit, and can accurately monitor and sense the strain and position changes of the hernia repair mesh after the part is absorbed by the human body, which helps to timely detect abnormal conditions, such as mesh displacement, uneven force, etc., thereby effectively preventing hernia recurrence; the connection part (such as gold wire, silver paste) and the wireless communication part are connected in coordination to ensure the stability of sensor signal transmission. The wireless communication method makes data transmission not limited by physical lines, which is convenient for medical staff to remotely obtain monitoring data in real time, adjust treatment plans in time, provide patients with safer and more efficient intraoperative and postoperative monitoring, and improve the quality of rehabilitation.

[0046] like Figure 2 As shown, in the second aspect, a method for preparing a partially absorbable intelligent hernia repair mesh comprises the following steps:

[0047] Step S100: obtaining a monofilament unit;

[0048] Specifically, step S100 includes:

[0049] Step S100 includes: the main body is made of polypropylene injection molding pellets, the skeleton is made of polyglycolide injection molding pellets, the skeleton has a cross-section in the shape of a cross, the mass fraction of polyglycolide is 60%, and the mass fraction of polypropylene is 40%.

[0050] In the present application, the mass fraction ratio of the skeleton part to the main body part ranges from 6 / 4 to 7 / 3, and the mass fraction ratio range includes values ​​of 6 / 4 and 7 / 3. Polypropylene, as the raw material of the main body part, has high strength and hardness, can provide a stable support structure for the hernia repair mesh, and effectively withstand intra-abdominal pressure. Polyglycolide, as the raw material of the skeleton part and with a high mass fraction, can be gradually absorbed in the human body, reducing the problem of long-term foreign body residues. At the same time, it has good biocompatibility and reduces the risk of immune response and inflammation. The cross-shaped cross-section is conducive to better distribution of stress, enhancing the overall performance of the hernia repair mesh, and improving the repair effect and patient comfort.

[0051] Step S200: the antibacterial unit is at least partially formed on the surface of the monofilament unit;

[0052] Specifically, step S200 includes:

[0053] Step S201: adding nanoparticles of the antibacterial unit into a solvent or a carrier;

[0054] For example, anhydrous ethanol with a concentration of 1% (mass concentration w / v) is used as the solvent required for coating, the concentration of silver nanoparticles is adjusted to 6×10-3 mol / L, and the stirring rate is 200 r / min at room temperature, and the silver nanoparticles are added to the solvent. Of course, a suitable carrier in the prior art can also be selected according to actual needs.

[0055] Step S202: uniformly dispersing the antibacterial nanoparticles;

[0056] In some embodiments, ultrasonic treatment, mechanical stirring or other methods can be used to make it uniformly dispersed. For example, in the present application, ultrasonic oscillation treatment is used for 12 hours at room temperature to make the antibacterial nanoparticles uniformly dispersed.

[0057] Step S203: coating the antibacterial nanoparticles on the surface of the monofilament unit;

[0058] In some embodiments, a suitable coating method can be selected according to the shape, size and coating requirements of the surface of the monofilament unit, such as dipping, spraying, brushing, spin coating, etc., and preferably spraying or dipping can be used to ensure that the antibacterial nanoparticles can evenly cover the entire surface. Furthermore, the concentration of the antibacterial nanoparticles and the amount of the dispersant can be adjusted to obtain the best coating effect.

[0059] In the present application, Figure 3 As shown, the surface of the obtained single-filament unit is pretreated, the single-filament unit is placed on a substrate, Ag+ ions and high-pressure hot air are introduced, the high-pressure hot air drives the flow of Ag+ ions, and a spraying method is used. The spray gun is controlled to be 10 cm away from the single-filament unit, the tilt angle is 90°, and the spraying angular velocity w is between 0.3-0.5 m / s to coat the antibacterial nanoparticles on the surface of the single-filament unit.

[0060] Step S204: at room temperature, the surface of the monofilament unit coated with the antibacterial nanoparticles is placed in a dark environment for drying to remove the solvent or carrier so that the antibacterial nanoparticles are fixed on the surface of the monofilament unit.

[0061] In some embodiments, the surface of the monofilament unit coated with antibacterial nanoparticles is placed in a dark environment for drying. When removing the solvent or carrier, the drying temperature and time can be adjusted according to the selected solvent or carrier and the properties of the antibacterial nanoparticles.

[0062] Step S205: performing a curing treatment on the surface of the monofilament unit to which the antibacterial particles are fixed.

[0063] In some embodiments, the surface of the coated monofilament unit is cured by heat treatment, ultraviolet irradiation or other chemical and physical methods to improve the adhesion and stability of the antibacterial nanoparticles. For example, in the present invention, the surface of the coated monofilament unit can be cured by irradiating the monofilament unit with 365nm ultraviolet light for 30 minutes at a distance of 5cm from the surface of the monofilament unit.

[0064] In the present application, in step S201, step S202, and step S203, the nanoparticles can be evenly distributed in the solvent / carrier by precisely controlling the solvent concentration / carrier concentration, nanoparticle concentration, stirring rate, etc.; a variety of dispersion methods and appropriate coating methods ensure that the nanoparticles are evenly covered on the surface of the monofilament unit and effectively fight bacteria; in step S204, the drying treatment removes the solvent or carrier, so that the antibacterial nanoparticles are firmly attached to the surface of the monofilament unit, and the dark environment can prevent some nanoparticles from being affected by light, ensuring their stable performance; in step S205, the curing treatment further enhances the adhesion of the antibacterial nanoparticles on the surface of the monofilament unit and improves the antibacterial durability, thereby better preventing infection and facilitating recovery after hernia repair surgery.

[0065] Step S300: a plurality of antibacterial monofilament units are connected to form a hernia repair mesh body, and a monitoring unit is connected to the hernia repair mesh body.

[0066] Specifically, step S300 includes:

[0067] Step S301: Softening the monofilament unit with antibacterial properties. According to the design requirements of the hernia repair mesh, a double-needle-bed jacquard warp knitting machine is selected. The guide bars adopt a one-through-one-out threading method and a weft-lining guide bar is added. The hole shape of the patch is set to a hexagonal shape, and a multi-guide bar configuration is adopted;

[0068] In the present application, firstly, a mechanical method is used to make the monofilament unit with antibacterial function softer, thereby improving the spinnability and comfort of the monofilament unit and enhancing the comfort: the antibacterial monofilament unit is softened, so that the hernia repair mesh can be more comfortable when in contact with human tissue, reduce friction and irritation to surrounding tissues, and improve the comfort of patients after surgery; in addition, a double-needle-bed jacquard warp knitting machine is used, and a specific warp threading method and a weft insertion comb are added to make the structure of the hernia repair mesh more stable. The hexagonal patch hole design and the multi-comb configuration are conducive to stress dispersion, thereby enhancing the stability of the hernia repair mesh when subjected to external forces such as abdominal pressure, better playing the repair role, and reducing the possibility of hernia recurrence.

[0069] Step S302: according to the knitting process requirements, the monofilament unit with antibacterial properties is inserted into the comb and appropriate knitting parameters are set. The patch has the same density in both the vertical and horizontal directions, which are m horizontal rows or m vertical lines per centimeter, where m is a positive integer and is greater than or equal to 2. The warp knitting machine is started for knitting. Multiple monofilament units with antibacterial properties are connected by weaving to form a hernia repair embryo net. During the weaving process, the sensor is integrated into a predetermined position of the hernia repair embryo net.

[0070] In some embodiments, preferably, m is equal to 10, such as Figure 4As shown in the figure, the schematic diagram of the movement of the hernia repair mesh pad yarn can be set according to the design requirements of the hernia repair mesh, and the appropriate number and configuration of the combs can be set, and the antibacterial and pretreated monofilament units can be inserted into the combs according to the weaving process requirements, and the tension of the antibacterial monofilament units can be ensured to be uniform. The yarn feeding system should be able to accurately control the conveying speed and conveying amount of the antibacterial monofilament units; at the same time, according to the performance requirements of the hernia repair mesh, appropriate weaving parameters are set, such as pulling density, needle bed moving speed, comb movement trajectory, etc., and the display monitoring system of the double needle bed jacquard warp knitting machine can be used to check various parameters in the weaving process in real time, such as the tension and pulling density of the antibacterial monofilament units, to ensure that the weaving process is stable and meets the predetermined requirements.

[0071] In some embodiments, the sensor (or sensor group) includes a strain sensor, a displacement sensor, etc., and a micro sensor or a spiral sensor coil, etc. can be selected. The sensor can be subjected to necessary pretreatment, such as cleaning, removing the oxide layer, coating with a protective agent, etc., to improve its long-term stability and biocompatibility; the integration position of the sensor can be determined according to the structure of the hernia repair mesh and monitoring requirements; and a suitable sensor integration method can be selected according to the type of sensor and the cross-sectional shape of the absorbable monofilament unit used in the hernia repair patch.

[0072] Step S303: after weaving is completed, the hernia repair mesh embryo is shaped to obtain the hernia repair mesh body;

[0073] In the present application, necessary finishing work may also be required, such as removing excess thread ends, trimming edges, etc. The shaping treatment of the hernia repair embryo mesh can make the structure of the obtained hernia repair mesh body more stable. During the weaving process, there may be some minor unstable factors in the mesh body, such as displacement of yarn or local looseness. The shaping treatment can eliminate these problems, ensure that the hernia repair mesh body can maintain its dimensional stability and shape flatness during use, and help to accurately control the size of the hernia repair mesh. The appropriate size can ensure that the repair mesh better fits the hernia defect site, improve the repair effect, and reduce complications and recurrence risks caused by inappropriate size. After the hernia repair embryo mesh is shaped, the durability of the hernia repair mesh is enhanced, and it can better withstand the effects of external forces and abdominal pressure generated by human activities, and appropriately extend the service life of the hernia repair mesh.

[0074] Step S304: Connect the sensor to the connecting unit, and the connecting unit is connected to the wireless communication unit.

[0075] In some embodiments, the connection part can use conductive components such as gold wire, silver paste, etc. The connection part connects the sensor to the wireless communication part, and the sensor and the connection part can be packaged and protected to prevent erosion by human body fluids, mechanical damage and electromagnetic interference.

[0076] In some embodiments, after the integration of the sensor and the connection part is completed, a suitable wireless communication part can be selected, the wireless communication part can be connected to the sensor, the data transmission protocol and frequency can be set, and the data can be accurately transmitted to an external receiver or mobile device. The corresponding data processing software can be developed to process, analyze and display the received data, and conduct comprehensive functional tests, including sensor performance tests, signal transmission tests, wireless communication tests, etc. According to the test results, necessary adjustments can be made to the sensor to ensure that the sensor can work normally and accurately reflect the physical quantities that need to be monitored.

[0077] In the present application, in step S300, the monofilament unit with antibacterial softening treatment can reduce friction with human tissue and improve comfort; the double-needle bed jacquard warp knitting machine and the specific configuration make the hernia repair mesh structure stable, with strong ability to withstand abdominal pressure and reduce the recurrence rate; the weaving parameters are precisely controlled to ensure the stability of the weaving process and weaving quality; the shaping treatment eliminates the unstable factors of weaving, maintains the size and shape, reduces complications, enhances durability, and ensures the effect and performance of subsequent hernia repair; the sensors are reasonably integrated, connected and packaged, and the wireless communication unit is selected, and the monitoring function is realized through testing and adjustment to ensure the normal operation of the hernia repair mesh.

[0078] Therefore, in the present application, firstly, the hernia repair mesh made of absorbable material not only improves the mechanical properties and biocompatibility of the hernia repair mesh, but also significantly reduces the incidence of complications after hernia repair. With the partial degradation of the monofilament unit, the growth and repair of the tissue are promoted, and the potential risks brought by long-term retention of foreign matter, such as infection, adhesion, etc., are avoided, thereby improving the patient's rehabilitation quality; at the same time, by coating the surface of the monofilament unit with antibacterial nanoparticles, the antibacterial properties and biosafety of the hernia repair material can be significantly improved. During the operation, the antibacterial unit can effectively reduce the risk of bacterial contamination and reduce the incidence of postoperative infection. The durability and stability of the antibacterial unit ensure that the repair material can still maintain a high-efficiency antibacterial effect during long-term use, providing a strong guarantee for the patient's rehabilitation; in addition, the hernia repair mesh is prepared using a warp-knitted mesh structure to ensure that the mesh has good air permeability and guarantees the mechanical properties, adaptability and biocompatibility of the hernia repair mesh. During the operation, the repair mesh can fit closely to the tissue around the hernia ring, provide stable mechanical support, and promote tissue healing. In addition, the introduction of intelligent monitoring technology has provided broad space for the innovation of hernia repair mesh. The integration and innovation of wireless sensing technology has brought intelligent and precise changes to hernia repair surgery. The innovative results achieved through multidisciplinary cross-integration have not only improved the safety and effectiveness of the operation, but also reduced the occurrence of postoperative complications of hernia repair, accelerated the patient's recovery process, and brought patients a more comfortable and convenient recovery experience.

[0079] The drawings are only one of the embodiments of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design a structure and embodiment similar to the technical solution without creativity without departing from the purpose of the present invention, they should all fall within the protection scope of the present invention.

Claims

1. A partially absorbable intelligent hernia repair mesh, comprising: A monofilament unit, an antibacterial unit and a monitoring unit, wherein part of the monofilament unit can be absorbed by the human body, a plurality of monofilament units are connected to form a hernia repair mesh body, the antibacterial unit is at least partially formed on the surface of the monofilament unit, the monitoring unit is connected to the hernia repair mesh body, and the monitoring unit monitors the strain and position of the hernia repair mesh.

2. A partially absorbable intelligent hernia repair mesh according to claim 1, characterized in that: The monofilament unit includes a skeleton part and a main body part. The skeleton part can be absorbed by the human body. The cross-section of the skeleton part is circular, cross-shaped or cross-shaped. The raw materials of the main body part include but are not limited to polypropylene and polyethylene. The raw materials of the skeleton part include but are not limited to polylactic acid, polycaprolactone, polyglycolide, and polycaprolactone-polyglycolide copolymer.

3. A partially absorbable intelligent hernia repair mesh according to claim 2, characterized in that: The antibacterial unit comprises antibacterial nanoparticles, which include but are not limited to silver nanoparticles, copper nanoparticles, and zinc oxide nanoparticles.

4. The partially absorbable intelligent hernia repair mesh according to claim 3, characterized in that: The monitoring unit includes a sensor, a connecting part and a wireless communication part. The sensor is connected to the single-filament unit and the connecting part. The connecting part is connected to the wireless communication part. The connecting part includes but is not limited to gold wire and silver paste.

5. A method for preparing a partially absorbable intelligent hernia repair mesh, comprising the following steps: Step S100: obtaining a monofilament unit; Step S200: the antibacterial unit is at least partially formed on the surface of the monofilament unit. Step S300: a plurality of antibacterial monofilament units are connected to form a hernia repair mesh body, and a monitoring unit is connected to the hernia repair mesh body.

6. The method for preparing a partially absorbable intelligent hernia repair mesh according to claim 5, characterized in that: Step S100 includes: the main body is made of polypropylene injection molding pellets, the skeleton is made of polyglycolide injection molding pellets, the skeleton has a cross-section in the shape of a cross, the mass fraction of polyglycolide is 60%, and the mass fraction of polypropylene is 40%.

7. The method for preparing a partially absorbable intelligent hernia repair mesh according to claim 6, characterized in that: Step S200 includes: Step S201: adding nanoparticles of the antibacterial unit into a solvent or a carrier; Step S202: uniformly dispersing the antibacterial nanoparticles; Step S203: coating the antibacterial nanoparticles on the surface of the monofilament unit; Step S204: placing the surface of the monofilament unit coated with antibacterial nanoparticles in a dark environment for drying at room temperature to remove the solvent or carrier so that the antibacterial nanoparticles are fixed on the surface of the monofilament unit; Step S205: performing a curing treatment on the surface of the monofilament unit to which the antibacterial particles are fixed.

8. The method for preparing a partially absorbable intelligent hernia repair mesh according to claim 7, characterized in that: Step S300 includes: Step S301: Softening the monofilament unit with antibacterial properties. According to the design requirements of the hernia repair mesh, a double-needle-bed jacquard warp knitting machine is selected. The guide bars adopt a one-through-one-out threading method and a weft-lining guide bar is added. The hole shape of the patch is set to a hexagonal shape, and a multi-guide bar configuration is adopted; Step S302: according to the knitting process requirements, the monofilament unit with antibacterial properties is inserted into the comb and appropriate knitting parameters are set. The patch has the same density in both the vertical and horizontal directions, which are m horizontal rows or m vertical lines per centimeter, where m is a positive integer and is greater than or equal to 2. The warp knitting machine is started for knitting. Multiple monofilament units with antibacterial properties are connected by weaving to form a hernia repair embryo net. During the weaving process, the sensor is integrated into a predetermined position of the hernia repair embryo net. Step S303: after weaving is completed, the hernia repair mesh embryo is shaped to obtain the hernia repair mesh body; Step S304: Connect the sensor to the connecting unit, and the connecting unit is connected to the wireless communication unit.

9. According to the method for preparing a partially absorbable intelligent hernia repair mesh according to claim 8, in step S203, the surface of the obtained monofilament unit is pretreated, and a spraying method is used, the spray gun is controlled to be 10 cm away from the monofilament unit, the inclination angle is 90°, and the spraying speed is between 0.3-0.5 m / s, so that the antibacterial nanoparticles are coated on the surface of the monofilament unit.

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