Root canal filling material and preparation method thereof

Abstract

The invention provides a root canal filling material and a preparation method thereof.The root canal filling material comprises Iroot-sp paste and simethicone, the content of the simethicone is 5-20% of that of the Iroot-sp paste, by adding the simethicone, the hydrophilicity of the filling material is improved, the cavity is reduced, the filling tightness is remarkably improved, and the service life of the root canal filling material is prolonged. Therefore, wider clinical application scenes are met, and a better treatment effect is obtained.

Description

Technical Field

[0001] The present invention relates to the technical field of oral medical materials, and in particular to a root canal filling material and a preparation method thereof. Background Art

[0002] Root canal treatment (RCT) is an effective treatment commonly used in clinical practice to address infections in the dental pulp and around the root canals caused by severe caries, trauma, and tooth fractures. RCT completes the treatment by removing infected or inflamed pulp tissue, cleaning the root canal space, and then filling the root canal. Clinically, RCT uses strong and effective root canal irrigants, such as 2-5% NaClO, to eradicate microbial infections, but it is difficult to achieve complete disinfection of the complex root canal anatomy. Because the treatment effect depends largely on the sealing of the root canal space, the final filling step is a crucial step in root canal treatment.

[0003] Although there are many benefits to saving natural teeth through root canal treatment, RCT may fail due to inadequate sealing of infected root canals, allowing bacteria to re-grow within the root canal system, resulting in apical periodontitis and periapical abscesses. Ideally, the material used for root filling should be biocompatible, non-absorbable, insoluble in tissue fluids, able to provide sealing, and have good handling characteristics.

[0004] Iroot-sp is a highly biocompatible filling paste widely used in root canal therapy. However, in current clinical applications, Iroot-sp can cause significant microleakage and insufficient sealing. Therefore, it is crucial to minimize the generation of bubbles and cavities during root canal filling, optimize its application, and reduce leakage caused by insufficient root canal sealing, which ultimately leads to root canal treatment failure. Summary of the Invention

[0005] The present invention aims to address, at least to some extent, one of the technical problems in the related art. To this end, one object of the present invention is to provide a new root canal filling material and a method for preparing the same. The root canal filling material provided by the present invention, by adding dimethyl silicone oil, improves the hydrophilicity of the filling material and reduces cavitation, significantly enhancing its tight filling performance, thus meeting a wider range of clinical application scenarios and achieving better treatment results.

[0006] In one aspect, the present invention provides a root canal filling material. According to an embodiment of the present invention, the root canal filling material comprises Iroot-sp paste and dimethicone, with the dimethicone content being 5-20% of the Iroot-sp paste, for example, 7%, 10%, 13%, 15%, 18%, etc. By adding dimethicone, the hydrophilicity of the filling material is improved and cavitation is reduced, significantly enhancing the filling tightness, thereby meeting a wider range of clinical application scenarios and achieving better treatment effects. By controlling the amount of dimethicone added, the present invention controls the hardness of the material to meet a wider range of clinical application scenarios.

[0007] According to an embodiment of the present invention, the root canal filling material may further include at least one of the following additional technical features:

[0009] According to an embodiment of the present invention, the Iroot-sp paste comprises zirconium oxide, calcium phosphate, calcium silicate, and calcium hydroxide. The main components of the Iroot-sp paste include zirconium oxide, calcium phosphate, calcium silicate, and calcium hydroxide. In the root canal filling material provided by the present invention, dimethyl silicone oil is used as a hydrophilic surfactant, which can significantly reduce air bubbles and cavities inside the material, making the root canal filling material have less cavitation and better hydrophilicity, significantly improving the filling tightness performance, and can effectively solve the problems of large microleakage and insufficient filling of the Iroot-sp paste in clinical applications, thereby having a more ideal effect in root canal treatment.

[0010] According to an embodiment of the present invention, the Iroot-sp paste does not contain nano magnesium hydroxide.

[0011] According to an embodiment of the present invention, the root canal filling material may further include an antibiotic. The present invention does not specifically limit the type of the antibiotic, and those skilled in the art may select the antibiotic according to actual needs. For example, the antibiotic includes, but is not limited to, one or more of penicillin, cephalosporin, and aminoglycoside antibiotics.

[0012] According to an embodiment of the present invention, the antibiotics include one or more of penicillin, cephalosporin, or aminoglycoside antibiotics. The antibiotics of the present invention have antibacterial and disinfecting effects, prevent periapical periodontitis, and can simplify the treatment course and shorten the treatment cycle.

[0013] According to an embodiment of the present invention, the root canal filling material may further include a gutta-percha point.

[0014] According to an embodiment of the present invention, the Iroot-sp paste and the dimethicone oil are attached to the surface of the gutta-percha tip.

[0015] According to an embodiment of the present invention, the root canal filling material can be used directly for root canal filling or combined with a gutta-percha tip for root canal filling.

[0016] In another aspect, the present invention further provides a method for preparing a root canal filling material. According to an embodiment of the present invention, the method comprises:

[0017] The Iroot-sp paste is mixed with dimethyl silicone oil to obtain a root canal filling material, wherein the content of the dimethyl silicone oil is 5-20% of the content of the Iroot-sp paste.

[0018] According to an embodiment of the present invention, the above method may further include at least one of the following additional technical features:

[0019] According to an embodiment of the present invention, the Iroot-sp paste includes zirconium oxide, calcium phosphate, calcium silicate and calcium hydroxide.

[0020] According to an embodiment of the present invention, the mixing process is performed by one or more of mixing with a blender, stirring, or ultrasonic vibration.

[0021] According to an embodiment of the present invention, the mixing process includes mixing before use and mixing during use.

[0022] The term "mixing before use" as used herein refers to mixing the Iroot-sp paste and dimethicone before filling, and the term "mixing during use" refers to mixing the Iroot-sp paste and dimethicone during filling. The filling methods used herein include one or more of direct introduction, instrument introduction, and dipping.

[0023] According to an embodiment of the present invention, the method further comprises injecting an antibiotic into the root canal filling material;

[0024] According to an embodiment of the present invention, the antibiotics include one or more of penicillin, cephalosporin or aminoglycoside antibiotics.

[0025] The root canal filling material of the present invention can also be used as a filling material for bone tissue.

[0026] The technical solution provided by the embodiment of the present invention has at least one of the following advantages compared with the prior art:

[0027] 1. The root canal filling material provided by the present invention is a mixture of Iroot-sp paste and dimethyl silicone oil, which is beneficial to enhancing the hydrophilicity of the root canal filling material, expelling gas in the internal gap and achieving better sealing.

[0028] 2. The present invention controls the amount of dimethyl silicone oil added to prepare a filling material product that can be applied to different application scenarios such as teeth and bones.

[0029] 3. When the content of dimethyl silicone oil is controlled to be 5-20% of the content of Iroot-sp paste, the performance of the prepared root canal filling material is optimal. If it is lower or higher than this range, the performance will deteriorate. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the following description of the embodiments with reference to the accompanying drawings, in which:

[0031] Figure 1 The figure is a line graph of elastic modulus and hardness of root canal filling materials with different dimethyl silicone oil contents;

[0032] Figure 2 This is a line graph of the filling rate of root canal filling materials with different dimethyl silicone oil contents;

[0033] Figure 3 Microscope photos of contact angle tests of root canal filling materials with different dimethicone oil contents;

[0034] Figure 4 The figure shows the contact angle test results of root canal filling materials with different dimethyl silicone oil contents. DETAILED DESCRIPTION

[0035] In order to more clearly understand the above-mentioned objectives, features and advantages of the present invention, the scheme of the present invention will be further described below. It should be noted that, in the absence of conflict, the embodiments of the present invention and the features therein can be combined with each other.

[0036] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein; it is obvious that the embodiments in the specification are only part of the embodiments of the present invention, rather than all the embodiments.

[0037] The preparation method of the present invention is to directly physically mix the Iroot-sp paste and dimethyl silicone oil to obtain the paste.

[0038] The Iroot-sp paste used in this invention is a finished product and has been used as a conventional material in oral clinics. It has antibacterial properties with a pH > 12. The Iroot-sp used in this invention was purchased from Innovative Biocreamix Inc.

[0039] Example 1

[0040] This embodiment provides a root canal filling material, which consists of Iroot-sp paste and dimethyl silicone oil containing 5% of Iroot-sp paste.

[0041] Example 2

[0042] This embodiment provides a root canal filling material, which differs from Example 1 in that the content of the dimethyl silicone oil is 10% of the content of the Iroot-sp paste.

[0043] Example 3

[0044] This embodiment provides a root canal filling material, which differs from Example 1 in that the content of the dimethyl silicone oil is 15% of the content of the Iroot-sp paste.

[0045] Example 4

[0046] This embodiment provides a root canal filling material, which differs from Example 1 in that the content of the dimethyl silicone oil is 20% of the content of the Iroot-sp paste.

[0047] Comparative Example 1

[0048] This embodiment provides a root canal filling material, which differs from Embodiment 1 in that dimethyl silicone oil is not added.

[0049] Root canal filling material performance test

[0050] Performance tests were performed on the root canal filling materials in the examples and comparative examples to determine the effect of the amount of dimethyl silicone oil added on the material properties.

[0051] 1. Elastic modulus and hardness test

[0052] The elastic modulus and hardness test were performed using a nanoindenter. The test results are as follows: Figure 1 As shown. Figure 1 It can be seen that when the addition amount of dimethyl silicone oil is 5-10% of the Iroot-sp paste, the elastic modulus and hardness both increase, the rigidity of the root canal filling material increases, and it is not easy to deform. When the addition amount is 10-20% of the Iroot-sp paste, the elastic modulus and hardness both gradually decrease, and the flexibility of the root canal filling material increases.

[0053] 2. Void rate

[0054] Micro CT was used to perform in vitro simulation tests, and the test results were as follows: Figure 2 As shown. Figure 2It can be seen that when the addition amount of dimethicone oil starts from 5% of Iroot-sp paste, the cavity rate begins to decrease. When the addition amount is between 10-20%, the cavity rate is significantly reduced compared with the root canal filling material without adding dimethicone oil.

[0055] 3. Hydrophilicity

[0056] The contact angle meter is used for measurement. When the contact angle is less than 90°, the material surface is considered to be hydrophilic, that is, the liquid spreads easily on the material surface; when the contact angle is greater than 90°, the material surface is considered to be hydrophobic, that is, the droplets formed by the liquid on the material surface have a relatively rounded shape. The test results are as follows: Figure 3 and Figure 4 As shown. Figure 3 and Figure 4 It can be seen that when the addition amount of dimethicone oil starts from 5% of Iroot-sp paste, the contact angle gradually decreases from above 90° to below 90°, and the hydrophilicity of the root canal filling material gradually increases.

[0057] In summary, the root canal filling material provided by the present invention has enhanced flexibility, reduced cavitation, enhanced hydrophilicity, and significantly improved filling tightness performance. When applied in clinical scenarios, it can achieve better treatment effects.

[0058] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article, or device comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or device. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of other identical elements in the process, method, article, or device comprising the element.

[0059] The foregoing description is intended only to provide specific embodiments of the present invention, which will enable those skilled in the art to understand and implement the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not intended to be limited to the embodiments described herein, but is to be construed in the widest manner consistent with the principles and novel features disclosed herein.

[0060] In the description of this specification, the reference terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and features of different embodiments or examples without contradiction.

[0061] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A root canal filling material, characterized in that: The root canal filling material comprises Iroot-sp paste and dimethicone oil, and the content of the dimethicone oil is 5-20% of the content of the Iroot-sp paste.

2. The root canal filling material according to claim 1, characterized in that: The Iroot-sp paste includes zirconium oxide, calcium phosphate, calcium silicate and calcium hydroxide.

3. The root canal filling material according to claim 1, characterized in that: The Iroot-sp paste does not contain nano magnesium hydroxide.

4. The root canal filling material according to claim 1, characterized in that: The root canal filling material may further include antibiotics.

5. The root canal filling material according to claim 4, characterized in that: The antibiotics include one or more of penicillin, cephalosporin or aminoglycoside antibiotics.

6. The root canal filling material according to any one of claims 1 to 5, characterized in that: The root canal filling material may further include gutta-percha points; Optionally, the Iroot-sp paste and the dimethicone are attached to the surface of the gutta-percha tip.

7. A method for preparing a root canal filling material, characterized in that: include: The Iroot-sp paste is mixed with dimethyl silicone oil to obtain a root canal filling material, wherein the content of the dimethyl silicone oil is 5-20% of the content of the Iroot-sp paste.

8. The method according to claim 7, characterized in that The Iroot-sp paste includes zirconium oxide, calcium phosphate, calcium silicate and calcium hydroxide.

9. The method according to claim 7, characterized in that: The mixing process is carried out by one or more of the following methods: mixing with a mixing knife, stirring or ultrasonic vibration; Optionally, the mixing process includes mixing before use and mixing during use.

10. The method according to claim 7, characterized in that The method further comprises injecting an antibiotic into the root canal filling material; Optionally, the antibiotic comprises one or more of a penicillin, a cephalosporin or an aminoglycoside antibiotic.

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