Qi-tonifying and yin-nourishing pharmaceutical composition as well as preparation method and application thereof

Abstract

The invention discloses a medicinal composition for tonifying qi and nourishing yin as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention discloses a medicinal composition for tonifying qi and nourishing yin. The medicinal composition is prepared from the following raw materials: 20 to 50g of tortoise-shell glue, 150 to 250g of honey-fried polygala tenuifolia, 300 to 500g of dragon bone, 300 to 500g of lucid ganoderma, 30 to 60g of schisandra chinensis, 150 to 250g of radix ophiopogonis, 150 to 250g of rhizoma acori graminei, 100 to 150g of codonopsis pilosula, 50 to 100g of ginseng and 300 to 500g of poria cocos. Wherein the schisandra chinensis is prepared from vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1: 2. The Chinese magnoliavine fruit processed with vinegar and the Chinese magnoliavine fruit processed with wine in a specific ratio are adopted, the effect of remarkably increasing the content of ganoderic acid A and schizandrin in the composition is achieved, the content of effective components in the composition is high, and the composition has the excellent effects of tonifying qi, nourishing yin, treating the deficiency of both qi and yin and improving sleep and memory.

Description

Technical Field

[0001] The invention relates to a medicinal composition for replenishing qi and nourishing yin, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. Background Art

[0002] Yinao Capsule is an OTC medicine with the national medicine standard Z10983042. It has the effects of replenishing qi and yin, nourishing the kidney and brain, improving intelligence and calming the mind. It is used for neurasthenia, fatigue and dizziness, insomnia and dreaminess. The prescription composition and preparation process are as follows: Prescription: Turtle Shell Glue 38.6g Polygala 193.3g Dragon Bone 387.3g Ganoderma Lucidum 387.3g Schisandra 49.3g Ophiopogon 193.3g Acorus Gramineus 193.3g Codonopsis pilosula 111.0g Ginseng 66.6g Poria 387.3g. Preparation process: The above ten ingredients, except tortoise shell glue, ginseng and Poria cocos (25%) are crushed into fine powder respectively, and the remaining Poria cocos and other seven ingredients including Polygala tenuifolia are decocted in water twice, the first time for 3 hours and the second time for 2 hours, filtered, combined with the filtrate, concentrated into a thick paste, added with ginseng, Poria cocos powder and dissolved tortoise shell glue, mixed thoroughly, dried, ground into fine powder, sieved, put into capsules, and made into 1000 capsules.

[0003] The existing Yinao Capsules have been tested for content, and the content of ganoderic acid A is about 0.19 mg / g, and the content of schisandrae alcohol A is about 0.16 mg / g. Therefore, there is an urgent need for a Qi-tonifying and Yin-nourishing pharmaceutical composition capable of increasing the content of effective ingredients, as well as a preparation method and application thereof. Summary of the invention

[0004] In view of the above problems, the object of the present invention is to provide a medicinal composition for invigorating qi and nourishing yin. In the composition, honey Polygala, vinegar Schisandra and wine Schisandra are used to replace Polygala and Schisandra in the original formula. Vinegar Schisandra guides the medicine into the liver, nourishes yin and liver, and promotes drug metabolism and absorption; wine Schisandra guides the medicine upward, promotes fluid production and quenches thirst, and is used for thirst due to lack of fluid, and deficiency of both qi and yin. The composition works synergistically to achieve the effect of treating deficiency of both qi and yin and improving sleep and memory.

[0005] Meanwhile, the present invention provides a method for preparing a medicinal composition for invigorating qi and nourishing yin, wherein the composition obtained by the method has high contents of ganoderic acid A and schisandrae alcohol A.

[0006] At the same time, the present invention provides an application of a qi-tonifying and yin-nourishing medicinal composition in the preparation of a qi-tonifying and yin-nourishing medicament.

[0007] At the same time, the present invention provides an application of a medicinal composition for replenishing qi and nourishing yin in preparing a medicine for treating qi and yin deficiency syndrome.

[0008] At the same time, the present invention provides a Qi-tonifying and Yin-nourishing medicine, which is prepared from the Qi-tonifying and Yin-nourishing medicine composition of the present invention.

[0009] At the same time, the present invention provides a medicine for treating qi and yin deficiency syndrome, which is prepared from the qi-invigorating and yin-nourishing medicine composition of the present invention.

[0010] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0011] A medicinal composition for invigorating qi and nourishing yin comprises the following raw materials: 20-50g of tortoise shell glue, 150-250g of honey polygala, 300-500g of dragon bone, 300-500g of ganoderma lucidum, 30-60g of schisandra chinensis, 150-250g of ophiopogon japonicus, 150-250g of calamus tatarinowii, 100-150g of codonopsis pilosula, 50-100g of ginseng, and 300-500g of poria; wherein the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:2.

[0012] Preferably, a medicinal composition for invigorating qi and nourishing yin comprises the following raw materials: 38.6g of tortoise shell glue, 193.3g of honey polygala, 387.3g of dragon bone, 387.3g of ganoderma lucidum, 49.3g of schisandra chinensis, 193.3g of ophiopogon japonicus, 193.3g of calamus tatarinowii, 111.0g of codonopsis pilosula, 66.6g of ginseng, and 387.3g of poria; wherein the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:2.

[0013] A method for preparing a medicinal composition for replenishing qi and nourishing yin comprises the following steps:

[0014] S01, preparing vinegar schisandra: adding rice vinegar to clean and dry schisandra and mixing well, wherein the weight of the rice vinegar added is 10-20% of the dry weight of schisandra, and then steaming in a steamer until the surface of schisandra turns purple-black, and taking out and drying after steaming to obtain vinegar schisandra;

[0015] S02, preparing Schisandra chinensis wine: add rice wine to clean and dry Schisandra chinensis and mix well, the weight of the rice wine added is 30-40% of the dry weight of Schisandra chinensis, and steam it in a steamer for 0.5-1h after it is soaked overnight, then take it out, let it stand for 3-6h after cooling at room temperature, and then continue to steam it in a steamer for 0.5-1h. After the steaming is completed, take it out and dry it to obtain Schisandra chinensis wine;

[0016] S03, except for tortoise shell glue, ginseng and 25% Poria cocos are crushed into fine powder respectively, and the remaining 75% Poria cocos and honey Polygala, Dragon Bone, Ganoderma lucidum, Schisandra chinensis, Ophiopogon japonicus, Acorus calamus and Codonopsis pilosula are decocted in water for at least 2 times, the first time for 3 to 4 hours, and the rest times for 2 to 3 hours, filtered, combined with the filtrate, concentrated into a thick paste, added with ginseng, Poria cocos powder and dissolved tortoise shell glue, fully mixed, dried, and ground into fine powder.

[0017] Preferably, in S03, the fine powder is sieved through a 100-200 mesh sieve.

[0018] Preferably, in S03, water is added and boiled twice, the first time for 3 hours and the second time for 2 hours.

[0019] Preferably, in S03, the weight of the thick paste is 2 to 3 times the total weight of ginseng and 25% Poria cocos powder.

[0020] Preferably, in S03, the concentration is carried out under reduced pressure at 60-70°C.

[0021] Preferably, in S02, the rice wine is 15-20°.

[0022] The preparation method of the invention obtains a medicinal composition for invigorating qi and nourishing yin, wherein the content of ganoderic acid A is 0.2628-0.3142 mg / g, and the content of schisandrae alcohol A is 0.2265-0.2474 mg / g.

[0023] A method for preparing a qi-tonifying and yin-nourishing medicine comprising: providing a qi-tonifying and yin-nourishing medicine;

[0024] A medicinal composition for replenishing qi and nourishing yin is used in preparing a medicine for treating qi and yin deficiency syndrome.

[0025] A Qi-tonifying and Yin-nourishing medicine is prepared from the Qi-tonifying and Yin-nourishing medicine composition of this embodiment.

[0026] A medicine for treating qi and yin deficiency syndrome is prepared from the qi-invigorating and yin-nourishing medicine composition of this embodiment.

[0027] Compared with the prior art, the present invention has the following advantages:

[0028] The invention provides a medicine composition for invigorating qi and nourishing yin. In the composition, honey Polygala, vinegar Schisandra and wine Schisandra are used to replace Polygala and Schisandra in an original prescription. Vinegar Schisandra guides the medicine into the liver, nourishes yin and liver, and promotes drug metabolism and absorption; wine Schisandra guides the medicine upward, generates body fluid and quenches thirst, and is used for thirst due to lack of body fluid and deficiency of both qi and yin. The composition works synergistically to achieve the effects of treating deficiency of both qi and yin and improving sleep and memory.

[0029] In the present invention, the vinegar schisandra chinensis and the wine schisandra chinensis with a specific ratio, as well as the special method for preparing schisandra chinensis with wine, are combined to significantly increase the contents of ganoderic acid A and schisandrin A in the composition, and the content of effective ingredients in the formula is high, thereby playing an excellent role in replenishing qi and nourishing yin, treating qi and yin deficiency syndrome, and improving sleep and memory. DETAILED DESCRIPTION

[0030] The present invention will be further described in detail below in conjunction with specific examples. The following examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0031] Example 1

[0032] A medicinal composition for invigorating qi and nourishing yin comprises the following raw materials: 38.6g of tortoise shell glue, 193.3g of honey polygala, 387.3g of dragon bone, 387.3g of ganoderma lucidum, 49.3g of schisandra chinensis, 193.3g of ophiopogon japonicus, 193.3g of calamus tatarinowii, 111.0g of codonopsis pilosula, 66.6g of ginseng, and 387.3g of poria; wherein the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:2.

[0033] A method for preparing a medicinal composition for replenishing qi and nourishing yin comprises the following steps:

[0034] S01, preparing vinegar schisandra: add 2.46g of rice vinegar to 16.4g of clean and dry schisandra and mix well, let it soak overnight, and then steam it in a steamer until the surface of the schisandra turns purple-black. After the steaming is completed, take it out and dry it to obtain vinegar schisandra;

[0035] S02, preparing Schisandra chinensis wine: add 11.5g 15° rice wine to 32.9g clean and dry Schisandra chinensis and mix well, let it soak overnight, then steam it in a steamer for 0.5h, then take it out, let it stand for 5h after cooling at room temperature, then continue to steam it in a steamer for 0.5h, take it out and dry it after steaming, so as to obtain Schisandra chinensis wine;

[0036] S03, except for tortoise shell glue, ginseng and 25% of Poria cocos are crushed into fine powder (passed through a 100-mesh sieve), and the remaining 75% of Poria cocos and honey Polygala tenuifolia, Dragon Bone, Ganoderma lucidum, Schisandra chinensis, Ophiopogon japonicus, Acorus calamus and Codonopsis pilosula are decocted in water (the amount of water added each time must cover the medicinal materials) for two times, the first time for 3 hours and the second time for 2 hours, filtered, and the filtrate is combined and concentrated under reduced pressure at 65°C to a thick paste of 327g, and ginseng, Poria cocos powder and dissolved tortoise shell glue are added, mixed thoroughly, dried, and ground into fine powder (passed through a 100-mesh sieve).

[0037] A method for preparing a qi-tonifying and yin-nourishing medicine comprising: providing a qi-tonifying and yin-nourishing medicine;

[0038] A medicinal composition for replenishing qi and nourishing yin is used in preparing a medicine for treating qi and yin deficiency syndrome.

[0039] A Qi-tonifying and Yin-nourishing medicine is prepared from the Qi-tonifying and Yin-nourishing medicine composition of this embodiment.

[0040] A medicine for treating qi and yin deficiency syndrome is prepared from the qi-invigorating and yin-nourishing medicine composition of this embodiment.

[0041] Example 2

[0042] A medicinal composition for invigorating qi and nourishing yin comprises the following raw materials: 20g of tortoise shell glue, 250g of honey polygala, 300g of dragon bone, 300g of ganoderma lucidum, 60g of schisandra chinensis, 150g of ophiopogon japonicus, 150g of calamus tatarinowii, 100g of codonopsis pilosula, 100g of ginseng and 300g of poria; wherein the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:2.

[0043] A method for preparing a medicinal composition for replenishing qi and nourishing yin comprises the following steps:

[0044] S01, preparing vinegar schisandra: adding 2g of rice vinegar to 20g of clean and dry schisandra and mixing well, steaming overnight, and then steaming in a steamer until the surface of the schisandra turns purple-black, taking out and drying after steaming to obtain vinegar schisandra;

[0045] S02, preparing Schisandra chinensis wine: add 12g 20° rice wine to 40g clean and dry Schisandra chinensis and mix well, let it soak overnight, then steam it in a steamer for 1h, then take it out, let it stand for 3h after cooling at room temperature, then continue to steam it in a steamer for 1h, take it out and dry it after steaming, so as to obtain Schisandra chinensis wine;

[0046] S03, except for tortoise shell glue, ginseng and 25% of Poria cocos are crushed into fine powder (passed through a 200-mesh sieve), and the remaining 75% of Poria cocos and honey Polygala, Dragon Bone, Ganoderma lucidum, Schisandra chinensis, Ophiopogon japonicus, Acorus calamus and Codonopsis pilosula are decocted in water (the amount of water added each time must cover the medicinal materials) for 3 times, the first time for 4 hours, the second and third times for 3 hours each, filtered, and the filtrate is combined and concentrated under reduced pressure at 60°C to a thick paste of 525g, and ginseng, Poria cocos fine powder and dissolved tortoise shell glue are added, mixed thoroughly, dried, and ground into fine powder (passed through a 200-mesh sieve).

[0047] A method for preparing a qi-tonifying and yin-nourishing medicine comprising: providing a qi-tonifying and yin-nourishing medicine;

[0048] A medicinal composition for replenishing qi and nourishing yin is used in preparing a medicine for treating qi and yin deficiency syndrome.

[0049] A Qi-tonifying and Yin-nourishing medicine is prepared from the Qi-tonifying and Yin-nourishing medicine composition of this embodiment.

[0050] A medicine for treating qi and yin deficiency syndrome is prepared from the qi-invigorating and yin-nourishing medicine composition of this embodiment.

[0051] Example 3

[0052] A medicinal composition for invigorating qi and nourishing yin comprises the following raw materials: 50g of tortoise shell glue, 150g of honey polygala, 500g of dragon bone, 500g of ganoderma lucidum, 30g of schisandra chinensis, 250g of ophiopogon japonicus, 250g of calamus gramineus, 150g of codonopsis pilosula, 50g of ginseng, and 500g of poria; wherein the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:2.

[0053] A method for preparing a medicinal composition for replenishing qi and nourishing yin comprises the following steps:

[0054] S01, preparing vinegar schisandra: add 2g of rice vinegar to 10g of clean and dry schisandra and mix well, let it soak overnight, and then steam it in a steamer until the surface of the schisandra turns purple-black. After the steaming is completed, take it out and dry it to obtain vinegar schisandra;

[0055] S02, preparing Schisandra chinensis wine: add 8g 15° rice wine to 20g clean and dry Schisandra chinensis and mix well, let it soak overnight, then steam it in a steamer for 40min, then take it out, let it stand for 6h after cooling at room temperature, and then continue to steam it in a steamer for 50min. After steaming, take it out and dry it to obtain Schisandra chinensis wine;

[0056] S03, except for tortoise shell glue, ginseng and 25% Poria cocos are crushed into fine powder (passed through a 100-mesh sieve), and the remaining 75% Poria cocos and honey Polygala, Dragon Bone, Ganoderma lucidum, Schisandra chinensis, Ophiopogon japonicus, Acorus calamus and Codonopsis pilosula are decocted in water (the amount of water added each time must cover the medicinal materials) for 2 times, the first time for 3 hours and the second time for 2 hours, filtered, and the filtrate is combined and concentrated under reduced pressure at 70°C to a thick paste of 350g, and ginseng, Poria cocos powder and dissolved tortoise shell glue are added, mixed thoroughly, dried, and ground into fine powder (passed through a 100-mesh sieve).

[0057] A method for preparing a qi-tonifying and yin-nourishing medicine comprising: providing a qi-tonifying and yin-nourishing medicine;

[0058] A medicinal composition for replenishing qi and nourishing yin is used in preparing a medicine for treating qi and yin deficiency syndrome.

[0059] A Qi-tonifying and Yin-nourishing medicine is prepared from the Qi-tonifying and Yin-nourishing medicine composition of this embodiment.

[0060] A medicine for treating qi and yin deficiency syndrome is prepared from the qi-invigorating and yin-nourishing medicine composition of this embodiment.

[0061] Example 4

[0062] A medicinal composition for invigorating qi and nourishing yin comprises the following raw materials: 30g of tortoise shell glue, 200g of honey polygala, 400g of dragon bone, 350g of ganoderma lucidum, 50g of schisandra chinensis, 200g of ophiopogon japonicus, 220g of calamus gramineus, 130g of codonopsis pilosula, 80g of ginseng, and 400g of poria; wherein the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:2.

[0063] A method for preparing a medicinal composition for replenishing qi and nourishing yin comprises the following steps:

[0064] S01, preparing vinegar schisandra: add 2.5g of rice vinegar to 16.7g of clean and dry schisandra and mix well, let it soak overnight, and then steam it in a steamer until the surface of the schisandra turns purple-black. After steaming, take it out and dry it to obtain vinegar schisandra;

[0065] S02, preparing Schisandra chinensis wine: add 13.32g 20° rice wine to 33.3g clean and dry Schisandra chinensis and mix well, let it soak overnight, then steam it in a steamer for 30min, then take it out, let it stand for 4h after cooling at room temperature, and then continue to steam it in a steamer for 60min. After steaming, take it out and dry it to obtain Schisandra chinensis wine;

[0066] S03, except for tortoise shell glue, ginseng and 25% of Poria cocos are crushed into fine powder (passed through a 200-mesh sieve), and the remaining 75% of Poria cocos and honey Polygala tenuifolia, Dragon Bone, Ganoderma lucidum, Schisandra chinensis, Ophiopogon japonicus, Acorus calamus and Codonopsis pilosula are decocted in water (the amount of water added each time must cover the medicinal materials) for two times, the first time for 3 hours and the second time for 2 hours, filtered, and the filtrate is combined and concentrated under reduced pressure at 70°C to a thick paste of 540g, and ginseng, Poria cocos fine powder and dissolved tortoise shell glue are added, mixed thoroughly, dried, and ground into fine powder (passed through a 200-mesh sieve).

[0067] A method for preparing a qi-tonifying and yin-nourishing medicine comprising: providing a qi-tonifying and yin-nourishing medicine;

[0068] A medicinal composition for replenishing qi and nourishing yin is used in preparing a medicine for treating qi and yin deficiency syndrome.

[0069] A Qi-tonifying and Yin-nourishing medicine is prepared from the Qi-tonifying and Yin-nourishing medicine composition of this embodiment.

[0070] A medicine for treating qi and yin deficiency syndrome is prepared from the qi-invigorating and yin-nourishing medicine composition of this embodiment.

[0071] Example 5

[0072] A medicinal composition for invigorating qi and nourishing yin comprises the following raw materials: 40g of tortoise shell glue, 180g of honey polygala, 350g of dragon bone, 450g of ganoderma lucidum, 45g of schisandra chinensis, 170g of ophiopogon japonicus, 200g of calamus tatarinowii, 120g of codonopsis pilosula, 60g of ginseng, and 360g of poria; wherein the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:2.

[0073] A method for preparing a medicinal composition for replenishing qi and nourishing yin comprises the following steps:

[0074] S01, preparing vinegar schisandra: add 1.5g of rice vinegar to 15g of clean and dry schisandra and mix well, let it soak overnight, and then steam it in a steamer until the surface of the schisandra turns purple-black. After the steaming is completed, take it out and dry it to obtain vinegar schisandra;

[0075] S02, preparing Schisandra chinensis wine: add 9g 20° rice wine to 30g clean and dry Schisandra chinensis and mix well, let it soak overnight, then steam it in a steamer for 60min, then take it out, let it stand for 4.5h after cooling at room temperature, then continue to steam it in a steamer for 60min, take it out and dry it after steaming, so as to obtain Schisandra chinensis wine;

[0076] S03, except for tortoise shell glue, ginseng and 25% Poria cocos are crushed into fine powder (passed through a 100-mesh sieve), and the remaining 75% Poria cocos and honey Polygala, Dragon Bone, Ganoderma lucidum, Schisandra chinensis, Ophiopogon japonicus, Acorus calamus and Codonopsis pilosula are decocted in water (the amount of water added each time must cover the medicinal materials) for two times, the first time for 3 hours and the second time for 2 hours, filtered, and the filtrate is combined and concentrated under reduced pressure at 60°C to a thick paste of 300 g, and ginseng, Poria cocos fine powder and dissolved tortoise shell glue are added, mixed thoroughly, dried, and ground into fine powder (passed through a 100-mesh sieve).

[0077] A method for preparing a qi-tonifying and yin-nourishing medicine comprising: providing a qi-tonifying and yin-nourishing medicine;

[0078] A medicinal composition for replenishing qi and nourishing yin is used in preparing a medicine for treating qi and yin deficiency syndrome.

[0079] A Qi-tonifying and Yin-nourishing medicine is prepared from the Qi-tonifying and Yin-nourishing medicine composition of this embodiment.

[0080] A medicine for treating qi and yin deficiency syndrome is prepared from the qi-invigorating and yin-nourishing medicine composition of this embodiment.

[0081] Comparative Example 1

[0082] The difference between this comparative example and Example 1 is that in the composition, the Schisandra chinensis is vinegar Schisandra chinensis.

[0083] Comparative Example 2

[0084] The difference between this comparative example and Example 1 is that in the composition, the Schisandra chinensis is Schisandra chinensis wine.

[0085] Comparative Example 3

[0086] The difference between this comparative example and Example 1 is that in the composition, the Schisandra chinensis is vinegar Schisandra chinensis and wine Schisandra chinensis in a mass ratio of 1:1.

[0087] Comparative Example 4

[0088] The difference between this comparative example and Example 1 is that in the composition, the Schisandra chinensis is vinegar Schisandra chinensis and wine Schisandra chinensis in a mass ratio of 1:3.

[0089] Comparative Example 5

[0090] The difference between this comparative example and Example 1 is that the preparation method of Schisandra chinensis wine is as follows: 11.5 g of 15° rice wine is added to 32.9 g of clean and dry Schisandra chinensis and mixed well, and then placed in a steamer and steamed for 1 hour after being soaked overnight, and then taken out, cooled at room temperature, and then allowed to stand for 5 hours, and dried to obtain Schisandra chinensis wine.

[0091] Comparative Example 6

[0092] The difference between this comparative example and Example 1 is that the preparation method of Schisandra chinensis wine is as follows: 11.5g of 15° rice wine is added to 32.9g of clean and dry Schisandra chinensis and mixed well. After being soaked overnight, the mixture is placed in a steamer and steamed for 20 minutes. The mixture is then taken out, allowed to cool at room temperature and allowed to stand for 5 hours. The mixture is then placed in a steamer and steamed for 20 minutes. After the steaming is completed, the mixture is taken out and dried to obtain Schisandra chinensis wine.

[0093] Comparative Example 7

[0094] The difference between this comparative example and Example 1 is that the preparation method of Schisandra chinensis wine is as follows: 11.5g of 15° rice wine is added to 32.9g of clean and dry Schisandra chinensis and mixed well. After being soaked overnight, the mixture is placed in a steamer and steamed for 80min. The mixture is then taken out, allowed to cool at room temperature and allowed to stand for 5h. The mixture is then placed in a steamer and steamed for 80min. After the steaming is completed, the mixture is taken out and dried to obtain Schisandra chinensis wine.

[0095] The compositions of the above-mentioned embodiments and comparative examples were taken, and the contents of ganoderic acid A and schisandrae alcohol A were determined by the method in the prior art “CN202411357851 - A one-test dual-evaluation isocratic elution HPLC quantitative determination method for brain-enhancing capsules”. The results are shown in Table 1 below.

[0096] Table 1 Data table of the content of ganoderic acid A and schisandrae alcohol A

[0097]

[0098]

[0099] As can be seen from the above table, in the present invention, the specific ratio of vinegar Schisandra chinensis and wine Schisandra chinensis, as well as the special method of making Schisandra chinensis with wine, can significantly increase the content of ganoderic acid A and schisandrin A in the composition, thereby playing an excellent role in replenishing qi and nourishing yin, treating qi and yin deficiency syndrome, and improving sleep and memory.

[0100] It should be understood that in order to streamline the present disclosure and aid in understanding one or more of the various inventive aspects, in the above description of exemplary embodiments of the present invention, various features of the present invention are sometimes grouped together into a single embodiment, or description thereof. However, this disclosed method should not be interpreted as reflecting the intention that the claimed invention requires more features than those expressly recited in each claim. Rather, as reflected in the claims, inventive aspects lie in less than all of the features of the previously disclosed embodiments. Therefore, the claims that follow the detailed description are hereby expressly incorporated into the detailed description, with each claim itself serving as a separate embodiment of the present invention.

[0101] Although the present invention has been described according to a limited number of embodiments, it will be apparent to those skilled in the art, with the benefit of the above description, that other embodiments may be envisioned within the scope of the invention thus described. In addition, it should be noted that the language used in this specification is selected primarily for readability and teaching purposes, rather than for explaining or defining the subject matter of the present invention. Therefore, many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the appended claims. The disclosure of the present invention is illustrative, not restrictive, with respect to the scope of the present invention, which is defined by the appended claims.

[0102] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A medicinal composition for replenishing qi and nourishing yin, characterized in that: The invention comprises the following raw materials: 20-50g tortoise shell glue, 150-250g honey polygala, 300-500g dragon bone, 300-500g ganoderma lucidum, 300-60g schisandra chinensis, 150-250g ophiopogon japonicus, 150-250g calamus gramineus, 100-150g codonopsis pilosula, 50-100g ginseng and 300-500g poria; among which the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:

2.

2. A medicinal composition for replenishing qi and nourishing yin according to claim 1, characterized in that: The invention comprises the following raw materials: 38.6g tortoise shell glue, 193.3g honey polygala, 387.3g dragon bone, 387.3g ganoderma lucidum, 49.3g schisandra chinensis, 193.3g ophiopogon, 193.3g calamus, 111.0g codonopsis pilosula, 66.6g ginseng and 387.3g poria; among which the schisandra chinensis is vinegar schisandra chinensis and wine schisandra chinensis in a mass ratio of 1:

2.

3. A method for preparing a medicinal composition for replenishing qi and nourishing yin according to claim 1 or 2, characterized in that: The following steps are involved: S01, preparing vinegar schisandra: adding rice vinegar to clean and dry schisandra and mixing well, wherein the weight of the rice vinegar added is 10-20% of the dry weight of schisandra, and then steaming in a steamer until the surface of schisandra turns purple-black, and taking out and drying after steaming to obtain vinegar schisandra; S02, preparing Schisandra chinensis wine: add rice wine to clean and dry Schisandra chinensis and mix well, the weight of the rice wine added is 30-40% of the dry weight of Schisandra chinensis, and steam it in a steamer for 0.5-1h after it is soaked overnight, then take it out, let it stand for 3-6h after cooling at room temperature, and then continue to steam it in a steamer for 0.5-1h. After the steaming is completed, take it out and dry it to obtain Schisandra chinensis wine; S03, except for tortoise shell glue, ginseng and 25% Poria cocos are crushed into fine powder respectively, and the remaining 75% Poria cocos and honey Polygala, Dragon Bone, Ganoderma lucidum, Schisandra chinensis, Ophiopogon japonicus, Acorus calamus and Codonopsis pilosula are decocted in water for at least 2 times, the first time for 3 to 4 hours, and the rest times for 2 to 3 hours, filtered, combined with the filtrate, concentrated into a thick paste, added with ginseng, Poria cocos powder and dissolved tortoise shell glue, fully mixed, dried, and ground into fine powder.

4. The preparation method according to claim 3, characterized in that: In S03, the fine powder is sieved through a 100-200 mesh sieve.

5. The preparation method according to claim 3, characterized in that: In S03, add water and boil twice, the first time for 3 hours and the second time for 2 hours.

6. The preparation method according to claim 3, characterized in that: In S03, the weight of the thick paste is 2 to 3 times the total weight of ginseng and 25% Poria cocos powder.

7. The preparation method according to claim 3, characterized in that: In S03, the mixture is concentrated under reduced pressure at 60-70°C.

8. The preparation method according to claim 3, characterized in that: In S02, the rice wine is 15-20°.

9. A medicinal composition for replenishing qi and nourishing yin obtained by the preparation method according to claim 3, characterized in that: The content of ganoderic acid A is 0.2628-0.3142 mg / g, and the content of schisandrin A is 0.2265-0.2474 mg / g.

10. Use of the medicinal composition for replenishing qi and nourishing yin according to claim 9 in the preparation of medicaments for replenishing qi and nourishing yin.

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