Medicinal and edible composition based on qi regulating, blood activating and detoxifying method as well as preparation method and application of medicinal and edible composition

Abstract

The invention discloses a medicinal and edible composition based on a qi regulating, blood activating and detoxifying method and a preparation method and application thereof, belongs to the technical field of compositions, and particularly relates to the medicinal and edible composition which comprises the following components in parts by weight: 3-13 parts of ginseng, 5-15 parts of emblic leafflower fruit, 5-15 parts of raw coix seed, 1-12 parts of citron fruit, 1-12 parts of pummelo peel and 10-25 parts of dandelion. On the basis of a'qi regulating, blood activating and detoxifying method ', the medicinal and edible composition is prepared by taking medicinal and edible plants as raw materials, and the medicinal and edible composition basically covers pathogenesis essential points and associated syndrome element targets of CAG by regulating qi (regulating qi and tonifying qi), activating blood circulation to remove blood stasis and clearing away heat and toxic materials. The traditional Chinese medicine composition can assist in treating chronic atrophic gastritis, intestinal metaplasia and low-grade intraepithelial neoplasia, preventing gastric precancerous lesions and assisting in improving gastric mucosal injury, and compared with the prior art, the traditional Chinese medicine composition is small in toxic and side effects, high in acceptability and suitable for being taken for a long time.

Description

Technical Field

[0001] The invention belongs to the technical field of compositions, and in particular relates to a medicine-food homologous composition based on a method of regulating qi, activating blood circulation and detoxifying, and a preparation method and application thereof. Background Art

[0002] Precancerous lesions of gastric cancer (PLGC) refer to chronic atrophic gastritis accompanied by intestinal metaplasia and / or abnormal proliferation. It is a common and frequently occurring disease in clinical gastroenterology. Precancerous lesions of gastric cancer are important precursors of gastric cancer. Timely intervention and treatment can significantly reduce the incidence of gastric cancer.

[0003] Most patients with gastric precancerous lesions at home and abroad are advised to eat regularly, eat more fresh vegetables and fruits, eat high-quality protein, eat a light, low-salt diet, and eat less or avoid pickled, smoked, grilled, and fried foods. Supplementing folic acid, vitamin C, β-carotene, non-steroidal drugs, etc. can be used as a method for chronic atrophic gastritis (CAG) to prevent gastric cancer, but it is still controversial.

[0004] Currently, there are no Chinese or Western medicines with relatively clear targets for Hp-related CAG and gastric precancerous lesions on the market, and there is also a lack of products for Hp-related chronic atrophic gastritis precancerous lesions. Therefore, developing new prevention and treatment programs to delay the progression of gastric cancer, block the transformation of gastric "inflammation-cancer", and transform the treatment of gastric cancer into the prevention of gastric cancer, from "treatment" to "prevention" has great public health significance.

[0005] There are many studies on the treatment of gastric precancerous lesions with traditional Chinese medicine, such as CN117045762A, CN117281880A, CN112107668A and CN110193073A. However, patients with gastric precancerous lesions generally need long-term oral medication, which has low patient acceptance and certain safety risks. Therefore, it is very necessary to develop a medicine-food combination with advantages such as small side effects, higher acceptance and therapeutic effects. Summary of the invention

[0006] In view of the problems existing in the prior art, the present invention provides a medicine-food homologous composition based on the method of regulating qi, promoting blood circulation and detoxifying, and a preparation method and application thereof.

[0007] Gastric precancerous lesions belong to the category of "stomach distension". The inventor team regards gastroscopy as an extension of TCM visual diagnosis, and proposes to use the performance of gastroscopy as an indicator to monitor the evolution of gastric precancerous lesions of chronic atrophic gastritis-intestinal metaplasia-dysplasia. In the early stage of the disease, Helicobacter pylori (Hp) and other external evils invade the human body, and pathological products such as food accumulation, damp heat, and phlegm turbidity occupy the middle jiao spleen and stomach, causing qi and blood stagnation and stagnation, resulting in redness and edema of the gastric mucosa, and a large amount of white turbid mucus stagnation. During this period, the evil is strong and is in the stage of solid distension. After Hp is eradicated, the cause of the disease has been eliminated, the evil heat gradually subsides, the hot and hot evil consumes qi and hurts yin, simmers body fluids and blood, and the toxic evil is stuck and difficult to transform. The gastroscopy can show map-like redness and the whitening of the gastric fundus gland mucosa. Based on the different endoscopy performances in the process of "inflammation-cancer" transformation and a large number of clinical and basic studies, the pathogenesis of Hp-related chronic atrophic gastritis precancerous lesions "generating toxins due to heat" is proposed. Our team's previous clinical symptom investigation and research found that the pathological nature of chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) is mainly deficiency of the root and excess of the superficial symptoms. The root deficiency is mainly spleen and stomach weakness, while the superficial symptoms are qi stagnation, dampness obstruction, heat depression, food accumulation, blood stasis, etc. Therefore, regulating qi (regulating qi, invigorating qi), promoting blood circulation and removing blood stasis, clearing away heat and detoxifying can basically cover the pathogenesis of CAG and the associated symptom element targets. Based on this, the inventor team proposed the "Qi regulating, blood activating and detoxifying method" to treat Hp-related chronic atrophic gastritis precancerous lesions, and obtained the medicine and food homologous composition of the present invention with the function of regulating qi, blood activating and detoxifying by screening and compounding medicine and food homologous raw materials. The products prepared using the above-mentioned medicine and food homologous composition have the advantages of small side effects, higher acceptance, and therapeutic effects, which meet clinical needs.

[0008] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0009] In a first aspect, the present invention provides a medicine-food composition, comprising, by weight, 3-13 parts of ginseng, 5-15 parts of emblica fruit, 5-15 parts of raw coix seeds, 1-12 parts of citron, 1-12 parts of tangerine peel and 10-25 parts of dandelion.

[0010] Preferably, the edible and medicinal composition comprises, by weight, 7-11 parts of ginseng, 7-11 parts of emblica fruit, 8-12 parts of raw coix seeds, 3-9 parts of citron, 3-9 parts of tangerine peel and 10-20 parts of dandelion.

[0011] Further preferably, the medicine-food composition comprises, by weight, 9 parts of ginseng, 9 parts of emblica fruit, 10 parts of raw coix seeds, 6 parts of citron, 6 parts of tangerine peel and 15 parts of dandelion.

[0012] In some embodiments, the weight ratio of ginseng, emblica fruit and raw coix seed is 7-11:7-11:8-12; preferably 9:9:10.

[0013] In a second aspect, the present invention provides a method for preparing the aforementioned medicine-food composition, comprising the following steps:

[0014] The medicine and food composition is obtained by extracting ginseng, emblica fruit, raw coix seed, citron, red tangerine peel and dandelion with water, performing solid-liquid separation, concentrating and drying.

[0015] Preferably, the amount of water added in the water extraction is 5-10 times the total amount of ginseng, emblica fruit, raw coix seeds, citron, tangerine peel and dandelion.

[0016] More preferably, the water extraction temperature is 70-90°C and the time is 60-90 min.

[0017] Preferably, the solid-liquid separation comprises centrifugation and filtration.

[0018] Preferably, the concentration is reduced-pressure concentration, the concentration temperature is 70-80° C., and the vacuum degree is 0.07-0.01 MPa.

[0019] More preferably, the concentration is to concentrate to 15-35% of the volume of the original concentrated solution, more preferably to 18-30%; and preferably to 20-30%.

[0020] Preferably, the drying is freeze drying and / or spray drying, more preferably spray drying.

[0021] Specifically, the inlet air temperature of the spray drying is 150-160°C, and the outlet air temperature is 95-105°C.

[0022] In a third aspect, the present invention provides the use of the above-mentioned medicine-food composition in the preparation of products for improving diseases related to Helicobacter pylori infection.

[0023] In some embodiments, the application is the application of the above-mentioned medicine-food composition in the preparation of a drug for improving gastric precancerous lesions.

[0024] Preferably, the gastric precancerous lesions include at least one of chronic atrophic gastritis, intestinal metaplasia and low-grade intraepithelial neoplasia.

[0025] In some embodiments, the application is application of the above-mentioned medicine-food composition in the preparation of food for improving gastric mucosal damage.

[0026] In a fourth aspect, the present invention provides a medicine-food product, comprising the above-mentioned medicine-food composition and acceptable excipients.

[0027] The acceptable excipients described in the present invention are food-acceptable excipients or pharmaceutically acceptable excipients.

[0028] Preferably, the acceptable auxiliary materials include at least one of a filler, a sweetener, a sour agent and an anti-caking agent.

[0029] Further preferably, the filler is maltodextrin and / or starch; the sweetener is at least one of xylitol, sucralose, and erythritol; the acidulant is citric acid and / or malic acid; and the anti-caking agent is silicon dioxide and / or microcrystalline cellulose.

[0030] In a fifth aspect, the present invention provides a medicine-food solid beverage, comprising the medicine-food composition, a filler, a sweetener, fruit powder and an anti-caking agent.

[0031] Preferably, the medicine and food solid beverage comprises, by weight, 3-13 parts of ginseng, 5-15 parts of emblica, 5-15 parts of raw coix seeds, 1-12 parts of citron, 1-12 parts of tangerine peel, 10-25 parts of dandelion, 10-14 parts of filler, 6-8 parts of sweetener, 1-5 parts of fruit powder and 3-7 parts of anti-caking agent.

[0032] Further preferably, the medicine and food solid beverage comprises, by weight, 3-13 parts of ginseng, 5-15 parts of emblica fruit, 5-15 parts of raw coix seeds, 1-12 parts of citron, 1-12 parts of tangerine peel, 10-25 parts of dandelion, 10-14 parts of maltodextrin, 6-8 parts of xylitol and 3-7 parts of silicon dioxide.

[0033] More preferably, the medicine and food solid beverage comprises, by weight, 9 parts of ginseng, 9 parts of emblica fruit, 10 parts of raw coix seeds, 6 parts of citron, 6 parts of tangerine peel, 15 parts of dandelion, 10-14 parts of maltodextrin, 6-8 parts of xylitol and 3-7 parts of silicon dioxide.

[0034] In some embodiments, the preparation method of the medicine-food homologous solid beverage is: mixing the medicine-food homologous composition and auxiliary materials, dividing and packaging, and obtaining the solid beverage.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] (1) Based on the "Qi-regulating, blood-activating and detoxifying method", the inventors prepared the edible and medicinal composition of the present invention using edible and medicinal plants as raw materials. The edible and medicinal composition can regulate Qi (regulating Qi, invigorating Qi), activate blood circulation and remove blood stasis, and clear away heat and detoxify, basically covering the pathogenesis of CAG and the associated symptom elements and targets, and can assist in the treatment of chronic atrophic gastritis, intestinal metaplasia and low-grade intraepithelial neoplasia, prevent gastric precancerous lesions, and assist in improving gastric mucosal damage.

[0037] (2) Compared with the prior art, the raw materials of the present invention are all medicinal and edible plants, with small toxic and side effects, better safety, and suitable for long-term use.

[0038] (3) Compared with traditional Chinese medicine, the medicine-food homologous product prepared by the present invention has a good taste and is more acceptable to patients.

[0039] (4) The present invention not only maintains the nutritional and pharmacological effects of traditional medicinal materials, but also has been optimized in modern food technology, making it convenient for consumers to drink on a daily basis, and has the effects of enhancing immunity, resisting fatigue, resisting oxidation, and promoting digestion.

[0040] (5) The preparation method of the present invention is simple and the prepared product has good stability. DETAILED DESCRIPTION

[0041] The present invention is described below through specific embodiments to make the technical solution of the present invention easier to understand and grasp, but the present invention is not limited thereto, and the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments.

[0042] The endpoints and any value of the scope disclosed in this article are not limited to the accurate scope or value, and these scopes or values ​​should be understood to include values ​​close to these scopes or values. For numerical ranges, between the endpoint values ​​of each scope, between the endpoint values ​​of each scope and a separate point value, and between separate point values, one or more new numerical ranges can be combined with each other, and these numerical ranges should be considered as specifically disclosed in this article. Unless the context clearly indicates otherwise, the singular form "one", "a kind of" and "described" as used herein include singular and plural indicators. The numerical range described by the endpoint is included in all numerical values ​​and fractions within the corresponding range, as well as the described endpoint.

[0043] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should belong to the scope of protection of the present invention. The experimental methods described in the following embodiments are conventional methods unless otherwise specified. The reagents and materials, unless otherwise specified, can be obtained from commercial channels. The following reagent source information is illustrative and should not be used to limit the present invention.

[0044] 1. Qi-regulating, blood-activating and detoxifying method - medicine-food combination

[0045] Example 1: Medicine and food composition

[0046] The ingredients of the medicine-food composition of Example 1 are shown in Table 1.

[0047] Table 1 Composition of medicine and food

[0048] Serial number Components Weight 1 Ginseng 9 2 Phyllanthus emblica 9 3 Raw coix seed 10 4 citron 6 5 Huajuhong 6 6 Dandelion 15

[0049] According to the formula in Table 1, the medicine-food composition was prepared according to the following steps.

[0050] Step 1: Wash, remove impurities, cut (0.5 mm) the plant materials such as ginseng, emblica, raw coix seeds, citron, tangerine peel and dandelion, and dry them at 55° C. until the moisture content does not exceed 5%.

[0051] Step 2: Weigh the formulated amount of plant raw materials, add 8 times the amount of water, extract at 80°C for 80 minutes, filter, and obtain a clear solution.

[0052] Step 3: Concentrate the clear liquid under a vacuum environment of 80° C. and 0.08 MPa for 30 min to 25-30% of the volume of the original clear liquid to obtain a concentrated solution.

[0053] Step 4: spray-dry the concentrated solution, set the air inlet temperature to 160°C, and control the air outlet temperature to 95°C to obtain a medicine-food composition.

[0054] Example 2: Medicine and food composition

[0055] The ingredients of the medicine-food composition of Example 2 are shown in Table 2.

[0056] Table 2 Composition of medicine and food

[0057] Serial number Components Weight 1 Ginseng 7 2 Phyllanthus emblica 7 3 Raw coix seed 8 4 citron 1 5 Huajuhong 1 6 Dandelion 10

[0058] According to the formula in Table 2, the medicine-food composition was prepared according to the following steps.

[0059] Step 1: Wash, remove impurities, cut (0.5 mm) the plant materials such as ginseng, emblica, raw coix seeds, citron, tangerine peel and dandelion, and dry them at 55° C. until the moisture content does not exceed 5%.

[0060] Step 2: Weigh the formulated amount of plant raw materials, add 5 times the amount of water, extract at 70°C for 90 minutes, filter, and obtain a clear solution.

[0061] Step 3: Concentrate the clear liquid under a vacuum environment of 80° C. and 0.08 MPa for 30 min to 25-30% of the volume of the original clear liquid to obtain a concentrated solution.

[0062] Step 4: spray-dry the concentrated solution, set the air inlet temperature to 160°C, and control the air outlet temperature to 95°C to obtain a medicine-food composition.

[0063] Example 3: Medicine and food composition

[0064] The ingredients of the medicine-food composition of Example 3 are shown in Table 3.

[0065] Table 3 Composition of medicine and food

[0066] Serial number Components Weight 1 Ginseng 11 2 Phyllanthus emblica 11 3 Raw coix seed 12 4 citron 12 5 Huajuhong 12 6 Dandelion 25

[0067] According to the formula in Table 3, the medicine-food composition was prepared according to the following steps.

[0068] Step 1: Wash, remove impurities, cut (0.5 mm) the plant materials such as ginseng, emblica, raw coix seeds, citron, tangerine peel and dandelion, and dry them at 55° C. until the moisture content does not exceed 5%.

[0069] Step 2: Weigh the formulated amount of plant raw materials, add 10 times the amount of water, extract at 90°C for 60 minutes, filter, and obtain a clear solution.

[0070] Step 3: Concentrate the clear liquid under a vacuum environment of 80° C. and 0.08 MPa for 30 min to 25-30% of the volume of the original clear liquid to obtain a concentrated solution.

[0071] Step 4: spray-dry the concentrated solution, set the air inlet temperature to 160°C, and control the air outlet temperature to 95°C to obtain a medicine-food composition.

[0072] Comparative Example 1

[0073] The ingredients of the edible-medicinal composition of Comparative Example 1 are shown in Table 4, and the only difference from Example 1 is the weight ratio of ginseng, emblica fruit and raw coix seed.

[0074] Table 4 Composition of medicine and food

[0075] Serial number Components Weight 1 Ginseng 22 2 Phyllanthus emblica 3 3 Raw coix seed 3 4 citron 6 5 Huajuhong 6 6 Dandelion 15

[0076] The preparation method is the same as that of Example 1.

[0077] Comparative Example 2

[0078] The ingredients of the medicine-food composition of Comparative Example 2 are shown in Table 5. The only difference from Example 1 is that Citron and Citrus aurantium are replaced by Houttuynia cordata and Poria cocos, respectively.

[0079] Table 5 Composition of medicine and food

[0080]

[0081]

[0082] The preparation method is basically the same as that of Example 1.

[0083] Comparative Example 3: Medicine and food composition

[0084] The ingredients of the medicine-food composition of Comparative Example 3 are shown in Table 6. The difference from Example 1 is that the dosage relationship of citron, tangerine peel and dandelion raw materials is different.

[0085] Table 6 Composition of medicine and food

[0086] Serial number Components Weight 1 Ginseng 9 2 Phyllanthus emblica 9 3 Raw coix seed 10 4 citron 15 5 Huajuhong 5 6 Dandelion 7

[0087] The preparation method is the same as Example 1.

[0088] Clinical efficacy observation

[0089] A self-controlled before-after test was used to observe the clinical efficacy of the medicine-food combination. Fifty patients who visited the outpatient department of the Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine from November 15, 2024 to December 1, 2024 and were diagnosed with CAG or CAG with intestinal metaplasia (IM) or mild dysplasia (Dys) by gastroscopy and pathology and met the inclusion criteria were selected as research subjects.

[0090] Before the intervention, the basic information of the patients was collected, including age, gender, occupation, course of disease, past medical history, family history, etc., as well as information on the four diagnostic methods of traditional Chinese medicine (observation, auscultation, inquiry, palpation). The TCM symptom scale was used to evaluate the severity and frequency of symptoms such as stomach pain, bloating, acid reflux, belching, poor appetite, and fatigue. The intervention period was 2 weeks with products of regulating qi, promoting blood circulation, and detoxifying medicine and food of the same origin. After 2 weeks of intervention, the TCM symptom scale was filled in again to evaluate the clinical effect of the prescription of regulating qi, promoting blood circulation, and detoxifying medicine and food of the same origin in treating the disease. At the same time, a market research questionnaire was filled in to understand the patient's acceptance, satisfaction, and adverse reactions to the product. The basic information of the patients, information on the four diagnostic methods of traditional Chinese medicine, scores of the TCM symptom scale, and results of the market research questionnaire were collected in paper form. Count data were statistically analyzed using frequency, or chi-square test or Fisher's exact test was used. The independent sample t test was used for the two groups when the measurement data were normally distributed and had equal variance. The non-parametric rank sum test was used for those that did not conform to the normal distribution or had unequal variance. The difference was considered statistically significant when P < 0.05.

[0091] 2. Solid beverages that are both medicinal and edible

[0092] Embodiment 4 medicine and food solid beverage

[0093] The medicine-food solid beverage is composed of the following raw materials:

[0094] 3 parts of ginseng, 5 parts of emblica fruit, 5 parts of raw coix seeds, 1 part of citron, 1 part of dried orange peel and 10 parts of dandelion, 10 parts of maltodextrin, 6 parts of xylitol and 3 parts of silicon dioxide.

[0095] The preparation method is:

[0096] Step 1: Wash, remove impurities, cut (0.5 mm) the plant materials such as ginseng, emblica, raw coix seeds, citron, tangerine peel and dandelion, and dry them at 55° C. until the moisture content does not exceed 5%.

[0097] Step 2: Weigh the formulated amount of plant raw materials, add 10 times the amount of water, extract at 90°C for 60 minutes, filter, and obtain a clear solution.

[0098] Step 3: Concentrate the clear liquid under a vacuum environment of 80° C. and 0.08 MPa for 30 min to 25-30% of the volume of the original clear liquid to obtain a concentrated solution.

[0099] Step 4: spray-dry the concentrated solution, set the air inlet temperature to 160°C, and control the air outlet temperature to 95°C to obtain a medicine-food composition.

[0100] Step 5: Add the formulated amount of maltodextrin and xylitol to the edible-medicinal composition and mix evenly, then add silicon dioxide and mix evenly again, divide and package to obtain a solid beverage.

[0101] Example 5: Solid beverage with medicinal and edible properties

[0102] The medicine-food solid beverage is composed of the following raw materials:

[0103] 13 parts of ginseng, 15 parts of emblica fruit, 12 parts of raw coix seeds, 12 parts of citron, 12 parts of tangerine peel and 25 parts of dandelion, 14 parts of maltodextrin, 8 parts of xylitol and 7 parts of silicon dioxide.

[0104] The preparation method is the same as that of Example 4

[0105] Example 6: Solid beverage with medicinal and edible properties

[0106] The medicine-food solid beverage is composed of the following raw materials:

[0107] 9 parts of ginseng, 9 parts of emblica fruit, 10 parts of raw coix seeds, 6 parts of citron, 6 parts of tangerine peel and 15 parts of dandelion, 10 parts of maltodextrin, 7 parts of xylitol and 5 parts of silicon dioxide.

[0108] The preparation method is the same as Example 5.

[0109] The solid beverage prepared by the invention has good taste, can prevent agglomeration and moisture, and can ensure the long-term stability of food during packaging.

[0110] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A medicine-food composition, characterized in that: Calculated by weight, it includes 3-13 parts of ginseng, 5-15 parts of emblica fruit, 5-15 parts of raw coix seeds, 1-12 parts of citron, 1-12 parts of tangerine peel and 10-25 parts of dandelion.

2. The medicine-food composition according to claim 1, characterized in that: The medicine-food composition comprises, by weight, 7-11 parts of ginseng, 7-11 parts of emblica, 8-12 parts of raw coix seeds, 3-9 parts of citron, 3-9 parts of tangerine peel and 10-20 parts of dandelion; preferably, 9 parts of ginseng, 9 parts of emblica, 10 parts of raw coix seeds, 6 parts of citron, 6 parts of tangerine peel and 15 parts of dandelion.

3. The medicine-food composition according to claim 1, characterized in that: The weight ratio of ginseng, emblica fruit and raw coix seed is 7-11:7-11:8-12; preferably 9:9:

10.

4. The method for preparing the edible-medicinal composition according to any one of claims 1 to 3, characterized in that: The steps include: The medicine and food composition is obtained by extracting ginseng, emblica fruit, raw coix seed, citron, red tangerine peel and dandelion with water, performing solid-liquid separation, concentrating and drying.

5. The preparation method according to claim 4, characterized in that: The amount of water added in the water extraction is 5-10 times the total amount of ginseng, emblica fruit, raw coix seeds, citron, tangerine peel and dandelion; And / or, the water extraction temperature is 70-90°C and the time is 60-90 min.

6. Use of the edible-medicine composition according to any one of claims 1 to 3 or the edible-medicine composition prepared by the preparation method according to any one of claims 4 to 5 in preparing products for improving diseases related to Helicobacter pylori infection.

7. The use according to claim 6, characterized in that: The Helicobacter pylori infection-related diseases include gastric precancerous lesions and / or gastric mucosal damage; preferably, the gastric precancerous lesions include at least one of chronic atrophic gastritis, intestinal metaplasia and low-grade intraepithelial neoplasia.

8. A medicine and food product, characterized in that: It comprises the medicine-food composition according to any one of claims 1 to 3 or the medicine-food composition prepared by the preparation method according to any one of claims 4 to 5 and acceptable excipients; preferably, the acceptable excipients are food-acceptable excipients or excipients accepted in pharmaceutical classes.

9. The medicine-food homologous product according to claim 8, characterized in that: The acceptable auxiliary materials include at least one of fillers, sweeteners, acidulants, fruit powders and anti-caking agents; Preferably, the filler is maltodextrin and / or starch; the sweetener is at least one of xylitol, sucralose, and erythritol; the acidulant is citric acid and / or malic acid; and the anti-caking agent is silicon dioxide and / or microcrystalline cellulose.

10. A solid beverage that is both a medicine and food, characterized in that: A composition comprising at least one of a filler, a sweetener, a sour agent, a fruit powder and an anti-caking agent and the medicine-food composition according to any one of claims 1 to 3 or the medicine-food composition prepared by the preparation method according to any one of claims 4 to 5; Preferably, the medicine-food solid beverage comprises, by weight, 3-13 parts of ginseng, 5-15 parts of emblica, 5-15 parts of raw coix seeds, 1-12 parts of citron, 1-12 parts of tangerine peel, 10-25 parts of dandelion, 10-14 parts of filler, 6-8 parts of sweetener, 1-5 parts of fruit powder and 3-7 parts of anti-caking agent; Further preferably, the medicine and food solid beverage comprises, by weight, 3-13 parts of ginseng, 5-15 parts of emblica fruit, 5-15 parts of raw coix seeds, 1-12 parts of citron, 1-12 parts of tangerine peel, 10-25 parts of dandelion, 10-14 parts of maltodextrin, 6-8 parts of xylitol and 3-7 parts of silicon dioxide.

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