Liquid cleaning composition

Abstract

The invention relates to a liquid cleaning composition. In particular, the present invention relates to a liquid cleaning composition that provides improved deposition of the active substance octadecanoic acid when applied to a surface. The composition comprises octadecanoic acid and an organic acid having a pKa of 2.5 to 4.9, wherein the organic acid is not octadecanoic acid.

Description

Field of the Invention

[0001] The present invention relates to a cleaning composition. In particular, the present invention relates to a liquid cleaning composition that provides improved deposition of benefit agents. Background of the Invention

[0003] Several liquid cleaning compositions are known in the art, which contain one or another benefit agent, also known as an active substance. Such benefit agents or active substances are generally included in liquid cleaning compositions for the purpose of providing a beneficial effect. For example, moisturizers are included in cleaning compositions (e.g., hand washing compositions and body wash compositions) to provide a moisturizing effect.

[0004] However, the technical effects obtained by including active substances in cleaning compositions are often limited for a variety of reasons. One of the possible reasons is said to be the deposition of active substances on the surface to be cleaned or washed. Generally, it is challenging to deposit active substances on the surface by cleaning compositions, because the cleaning action usually includes the step of removing the composition from the surface (washing it off), typically within a few seconds to a few minutes after application. Therefore, it is very challenging to deposit active substances on the surface within a limited duration.

[0005] Therefore, there remains a need to provide a liquid cleaning composition that provides improved deposition of benefit agents such as octadecanoic acid.Examples of octadecanoic acids include 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, and conjugated linoleic acid.

[0006] The present invention has been found that liquid cleaning compositions comprising a selected amount of octadecanoic acid in combination with a selected amount of an organic acid having a certain pKa range, wherein the organic acids having a certain pKa range are organic acids other than octadecanoic acid, provide improved deposition of octadecanoic acid. For example, when octadecanoic acid (e.g., 12-hydroxystearic acid (12-HSA)) is used in combination with an organic acid having a pKa in the range of 2.5 to 4.9, such as benzoic acid (pKa=4.2), in a liquid cleaning composition, it results in improved deposition of 12-HSA on a surface such as the skin. SUMMARY OF THE INVENTION

[0008] Thus, in a first aspect, the present invention relates to a liquid cleaning composition comprising:

[0009] a. 0.01 to 2 wt%, preferably 0.1 to 2 wt% of octadecanoic acid; and

[0010] b. 0.01 to 5 wt. %, preferably 0.5 to 5 wt. % of an organic acid having a pKa in the range of 2.5 to 4.9,

[0011] wherein the organic acid is not the octadecanoic acid;

[0012] The octadecanoic acid is selected from 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid and mixtures thereof, and is preferably not stearic acid.

[0013] In a second aspect, the present invention relates to a method for improving the deposition of octadecanoic acid, comprising the steps of:

[0014] i. applying the composition of the first aspect to a surface; and

[0015] ii. at least partially removing the composition from the surface,

[0016] wherein the step of removing the composition is performed within 5 minutes of the step of applying the composition to the surface;

[0017] The octadecanoic acid is selected from 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid and mixtures thereof, and is preferably not stearic acid.

[0018] In a third aspect, the present invention relates to the use of an organic acid having a pKa in the range of 2.5 to 4.9 in a liquid cleaning composition comprising octadecanoic acid for improving the deposition of octadecanoic acid on a surface, wherein the organic acid having a pKa in the range of 2.5 to 4.9 is an organic acid other than octadecanoic acid;

[0019] The octadecanoic acid is selected from 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid and mixtures thereof, and is preferably not stearic acid. DETAILED DESCRIPTION OF THE INVENTION

[0021] Any feature of one aspect of the present invention can be used for any other aspect of the present invention. The word "comprising" is intended to mean "including", but not necessarily "consisting of" or "consisting of". In other words, the steps or options listed do not have to be exhaustive. Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this specification indicating the amount of material or reaction conditions, the physical properties of the material and / or the use thereof should be understood to be modified by the word "about". Numerical ranges expressed in the format of "from x to y" are understood to include x and y. When multiple preferred ranges are described in the format of "from x to y" for a particular feature, it should be understood that all ranges combining different endpoints are also considered. Unless otherwise stated, the amounts used herein are expressed in weight percentages based on the total weight of the composition, which can be abbreviated as "weight %". The use of any and all examples or exemplary language provided herein, such as "such as" is only to better illustrate the present invention, and is not intended to limit the scope of the claimed invention in any way.

[0022] Thus, in a first aspect, the present invention relates to a liquid cleaning composition comprising:

[0023] a. 0.01 to 2 wt%, preferably 0.1 to 2 wt% of octadecanoic acid; and

[0024] b. 0.01 to 5 wt. %, preferably 0.5 to 5 wt. % of an organic acid having a pKa in the range of 2.5 to 4.9,

[0025] wherein the organic acid is not the octadecanoic acid;

[0026] The octadecanoic acid is selected from 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid and mixtures thereof, and is preferably not stearic acid.

[0027] Liquid cleaning compositions

[0028] The present invention relates to a liquid cleaning composition (the composition) comprising 0.01 to 2 wt%, preferably 0.1 to 2 wt% of octadecanoic acid; and 0.01 to 5 wt%, preferably 0.5 to 5 wt% of an organic acid having a pKa in the range of 2.5 to 4.9, wherein the organic acid is not the octadecanoic acid. The octadecanoic acid is selected from 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid and mixtures thereof, preferably not stearic acid.

[0029] The composition is preferably applied to a surface which may be inanimate or animate. More preferably, the composition is applied to an animate substrate, e.g., human skin. As used herein, "skin" is preferably meant to include skin on any part of the body, e.g., face, neck, chest, back, arms, underarms, hands, legs, buttocks, and scalp. The composition is typically used with a suitable amount of water, which typically produces a foam.

[0030] Preferably, the viscosity of the composition ranges from 2500 to 4500 centipoise at 25°C, more preferably from 3000 to 3500 centipoise. Products with such viscosities are often referred to as liquid compositions, as they are free-flowing and pourable. Such liquid compositions are distinguished from gels and creams, which have a semi-solid consistency with a much higher viscosity.

[0031] Octadecanoic acid

[0032] The composition comprises octadecanoic acid. It should be understood that octadecanoic acid is an acid containing 18 carbon atoms in a chain that may be linear or branched; and at the same time may be saturated or unsaturated. The octadecanoic acid according to the invention may have substitutions on the carbon chain, for example, hydroxyl (-OH) groups.

[0033] The octadecanoic acid is selected from 10-hydroxystearic acid (10-HSA), 12-HSA, petroselinic acid, conjugated linoleic acid and mixtures thereof. More preferably, the octadecanoic acid is selected from 10-HSA, 12-HSA, petroselinic acid and mixtures thereof. Even more preferably, the octadecanoic acid is selected from 10-HSA, 12-HSA and mixtures thereof. Further more preferably, the selected octadecanoic acid is 12-HSA. The octadecanoic acid is preferably not stearic acid.

[0034] The composition comprises 0.01 to 2 wt%, preferably 0.05 to 1.5 wt%, more preferably 0.1 to 2 wt%, even more preferably 0.1 to 1 wt%, even more preferably 0.15 to 1 wt%, even more preferably 0.25 to 0.75 wt%, further more preferably 0.3 to 0.5 wt% of octadecanoic acid.

[0035] An organic acid having a pKa in the range of 2.5 to 4.9, wherein the organic acid is not the octadecanoic acid

[0036] The composition comprises an organic acid having a pKa in the range of 2.5 to 4.9, more preferably 2.5 to 4.7, even more preferably 2.9 to 4.5, which is not said octadecanoic acid.

[0037] It is understood that the organic acid with a pKa in the range of 2.5 to 4.9 is an organic acid other than the above-mentioned octadecanoic acid. Preferably, the organic acid with a pKa in the range of 2.5 to 4.9 does not contain any octadecanoic acid. Preferably, the octadecanoic acid is not stearic acid.

[0038] Preferably, these organic acids with a pKa in the range of 2.5 to 4.9 are selected from lactic acid (pKa=3.86), citric acid (pKa=3.13), glycolic acid (pKa=3.83), benzoic acid (pKa=4.2), caprylic acid (also known as caprylic acid; pKa=4.89), succinic acid (pKa=4.2), salicylic acid (also known as 2-hydroxybenzoic acid; pKa=2.97), butyric acid (pKa=4.82), phenylpropionic acid (pKa=4.66) and mixtures thereof; more preferably selected from lactic acid, glycolic acid, benzoic acid and mixtures thereof; even more preferably, the organic acid other than octadecanoic acid with a pKa in the range of 2.5 to 4.9 is benzoic acid.

[0039] The composition comprises 0.01 to 5 wt%, preferably 0.05 to 4 wt%, more preferably 0.1 to 3 wt%, even more preferably 0.5 to 3 wt%, even more preferably 1 to 2 wt% of these additional organic acids.

[0040] Anionic surfactants

[0041] Preferably, the composition further comprises an anionic surfactant selected from alkyl sulfates, alkyl ether sulfates (AES), alpha-olefin sulfonates (AOS) and mixtures thereof. More preferably, the anionic surfactant is selected from alkyl sulfates, alkyl ether sulfates and mixtures thereof. Even more preferably, alkyl ether sulfates are used as anionic surfactants in the composition.

[0042] Anionic surfactants are known to provide lather and cleansing action.

[0043] Examples of alkyl sulfates that may be used as anionic surfactants in the composition include sodium lauryl sulfate (SLS), sodium myristyl sulfate, and mixtures thereof.

[0044] Examples of AES that can be used as anionic surfactants include anionic surfactants having the following general formula:

[0045] R1-(OR') n -O-SO3 - M + ,in:

[0046] R1 is a saturated or unsaturated C8-C 16 , preferably C 12 -C 14 Preferably, R1 is a saturated C8-C 16 , more preferably saturated C 12 -C 14 Alkyl chain;

[0047] R' is ethylene; n is 1 to 18; preferably 1 to 15, more preferably 1 to 10, even more preferably 1 to 5,

[0048] M + is a suitable cation providing electroneutrality, preferably sodium, calcium, potassium or magnesium, more preferably a sodium cation.

[0049] Examples of AES that can be used as anionic surfactants in the composition include sodium lauryl ether sulfate (SLES), sodium myristyl ether sulfate and sodium palmityl ether sulfate and mixtures thereof. Preferred AES are SLES having 1 to 3 ethylene oxide units per molecule. More preferred are SLES having 1 to 2 ethylene oxide units per molecule.

[0050] Preferably, the composition comprises 1 to 20 wt. %, more preferably 3 to 18 wt. %, even more preferably 5 to 15 wt. %, further more preferably 8 to 14 wt. %, still more preferably 10 to 12 wt. % of anionic surfactant, which may be selected from one or more of the above-mentioned anionic surfactants.

[0051] Amphoteric surfactant

[0052] Preferably, the composition further comprises an amphoteric surfactant. They provide foam enhancement and improve the sensory appearance of the composition. Preferably, the amphoteric surfactant is selected from cocamidopropyl betaine (CAPB), cocamide monoethanolamide (CMEA), coconut oil amphoacetate and mixtures thereof.

[0053] Preferably, the composition comprises 1 to 5 wt%, more preferably 1.5 to 4.5 wt%, even more preferably 2 to 4 wt%, further more preferably 2 to 3.5 wt%, still more preferably 2.5 to 3 wt% of an amphoteric surfactant.

[0054] pH value of the composition

[0055] Preferably, the pH of the composition is in the range of 3 to 10, more preferably 3.5 to 9, even more preferably 4 to 9, further more preferably 4 to 8, still more preferably 4 to 7, still more preferably 4 to 7.5, still further more preferably 4 to 7, still further more preferably 4 to 6.5, even further more preferably 4 to 6, still further preferably 4 to 5. The pH can be adjusted using known pH adjusters such as sodium hydroxide and hydrochloric acid.

[0056] Preferably, the composition comprises from 0 to 0.001 wt% soap (salts of fatty acids). More preferably, the composition comprises 0 wt% soap, ie it does not comprise any amount of soap, or is free of soap.

[0057] polymer

[0058] Preferably, the composition further comprises a water-soluble / water-dispersible polymer. These polymers may be cationic, anionic, amphoteric or nonionic with a molecular weight greater than 100,000 Daltons. They are known to increase the viscosity and stability of liquid cleaning compositions to enhance the sensory feel of the skin during and after use and to enhance foam creaminess and foam stability. Such polymers may preferably be used in an amount of 0.1 to 10 wt %, more preferably 0.1 to 5 wt %, even more preferably 0.25 to 3 wt %, further more preferably 0.5 to 2 wt %.

[0059] Examples of water-soluble / water-dispersible polymers include carbohydrate gums such as cellulose gum, microcrystalline cellulose, cellulose gel, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, methylcellulose, ethylcellulose, guar gum, karaya gum, tragacanth gum, gum arabic, gum arabic, agar, xanthan gum, and mixtures thereof; modified and unmodified starch granules and pregelatinized cold water soluble starch; emulsion polymers such as or Aqua SF1; cationic polymers, such as modified polysaccharides, including those sold under the trade names or Cationic guar gum available from Rhone Poulenc; cationic modified cellulose such as cellulose from Amerchol Polymer JR 30 or JR 40; from Hercules or GPX196; a synthetic cationic polymer such as sold by Nalco and Cationic starches such as those sold by Staley Inc. 200, 300 and 400; cationic galactomannan, such as Henkel, Inc. series; LM-200; and Also suitable are high molecular weight polyethylene glycols, such as WSR-205(PEG 14M), WSR-N-60K(PEG 45) and WSR-301 (PEG 90M).

[0060] Preferably, the composition further comprises a polymer selected from vinyl pyrrolidone / vinyl acetate copolymers.

[0061] water

[0062] Preferably, the composition comprises 60 to 98 wt% water, more preferably 65 to 95 wt%, even more preferably 70 to 90 wt%, further more preferably 75 to 85 wt%, yet more preferably 80 to 85 wt% water.

[0063] Skin whitening agents

[0064] Preferably, the composition further comprises one or more skin whitening agents. Preferably, the skin whitening agent can be selected from ammonium lactate, arbutin, azelaic acid, kojic acid, butylated hydroxyanisole, butylated hydroxytoluene, citrate, 3-diphenylpropane derivatives, tannic acid, glucopyranosyl-1-ascorbate, gluconic acid, hydroquinone, 4-hydroxyanisole, linoleic acid, magnesium ascorbyl phosphate, 2,4-resorcinol derivatives, 3,5-resorcinol derivatives, vitamins such as vitamin B3, vitamin B6, vitamin B12, vitamin C, vitamin A, resorcinol derivatives and mixtures thereof.

[0065] preservative

[0066] Preferably, the composition further comprises a preservative to protect the composition from the growth of potentially harmful microorganisms. Particularly preferred preservatives include hydantoin derivatives, propionates, various quaternary ammonium compounds, phenoxyethanol, imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol. The amount of preservative is preferably in the range of 0.01 wt % to 2 wt %, more preferably 0.1 wt % to 1 wt %.

[0067] Emollients

[0068] The composition may further comprise an emollient such as stearyl alcohol, glyceryl monoricinoleate, mink oil, cetyl alcohol, isopropyl isostearate, stearic acid, isobutyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecane-2-ol, isocetyl alcohol, eicosanol, behenyl alcohol, cetyl palmitate, silicone oils such as dimethicone, di-n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl stearate , butyl stearate, polyethylene glycol, triethylene glycol, lanolin, cocoa butter, corn oil, cottonseed oil, olive oil, palm kernel oil, rapeseed oil, safflower seed oil, evening primrose oil, soybean oil, sunflower seed oil, avocado oil, sesame oil, coconut oil, peanut oil, castor oil, acetylated lanolin alcohol, petrolatum, mineral oil, butyl myristate, isostearic acid, palmitic acid, isopropyl linoleate, lauryl lactate, myristyl lactate, decyl oleate, myristyl myristate.

[0069] Optional Ingredients

[0070] The composition may further comprise a wide range of other optional ingredients such as antioxidants, biological additives, buffering agents, colorants, astringents, fragrances, humectants, sunscreens, conditioners, pH adjusters, skin soothing agents and skin healing agents.

[0071] In a second aspect, the present invention relates to a method for improving octadecanoic acid deposition, comprising the following steps:

[0072] i. applying the composition to a surface; and

[0073] ii. at least partially removing the composition from the surface,

[0074] Wherein the step of removing the composition is carried out within 5 minutes of the step of applying the composition on the surface. Preferably, the second step is carried out within 4 minutes, more preferably within 3 minutes, even more preferably within 2 minutes, such as 1 minute, 30 seconds and 15 seconds.

[0075] When carrying out the method of the second aspect, improved deposition of octadecanoic acid on the surface is obtained. Preferably, the method is non-therapeutic.

[0076] In a third aspect, the present invention relates to the use of an organic acid with a pKa in the range of 2.5 to 4.9 in a liquid cleaning composition comprising octadecanoic acid for improving the deposition of octadecanoic acid on a surface, wherein the organic acid with a pKa in the range of 2.5 to 4.9 is an organic acid other than said octadecanoic acid. Preferably, the use is non-therapeutic. For example, in a liquid cleaning composition, when octadecanoic acid (e.g., 12-hydroxystearic acid (12-HSA)) is used in combination with an organic acid with a pKa in the range of 2.5 to 4.9, such as benzoic acid (pKa=4.2), it results in improved deposition of 12-HSA on a surface such as the skin.

[0077] The present invention is further described with reference to the following non-limiting examples: Example

[0078] Embodiment A, 1-9:

[0079] Experimental protocol

[0080] Briefly, the compositions shown in Table 1 below were prepared using different concentrations of 12-HSA and benzoic acid (as shown in Table 1) in the surfactant solution at 85°C, which were then cooled to 25°C; and the pH was adjusted to the desired value.

[0081] Sedimentation assays were performed as follows:

[0082] The model skin sample, in vitro skin (Vitro Skin N-19 from the IMS test group) was cut into 5 cm x 5 cm. It was pre-wetted with 500 microliters of DI water and rubbed for 30 seconds with gloves on, and excess water was drained by shaking. 80 mg of the neat composition (as shown in Table 1 below) was applied to the in vitro skin. It was foamed for 20 seconds with fingertips wearing latex gloves. The foam was retained on the in vitro skin for 30 seconds. Thereafter, 100 ml of deionized water was used to rinse both sides of the in vitro skin for about 30 seconds. The active substances deposited on the in vitro skin were extracted in methanol by sonication in a bath sonicator for 20 minutes. The extract was analyzed using LC-MS. In short, the compositions shown in Table 1 below were prepared at 85°C using different concentrations of 12-HSA and benzoic acid (as shown below) in a surfactant solution, which were then cooled to 25°C; and the pH was adjusted to the desired value.

[0083] Table 1

[0084]

[0085] [Note: pH = 4.0 except for * (where pH = 9.0); water to 100]

[0086] Embodiment B, 10-12

[0087] Further compositions were prepared as shown in Table-2 below and the deposition of 12HSA was evaluated using the same procedure as used in the previous examples of Table-1. The data are summarized in Table-2 below:

[0088] Table 2

[0089]

[0090] The data in Table 2 above show that the organic acids according to the invention (pKa 2.5 to 4.9) (Examples 10 to 12) alone or in combination provide superior octadecanoic acid deposition as defined in the present invention compared to organic acids with higher pKa (lauric and myristic acids) (Example B).

Claims

1. A liquid cleaning composition comprising: a. 0.1 to 2 wt % octadecanoic acid; and b. 0.5 to 5 wt. % of an organic acid having a pKa in the range of 2.5 to 4.9, wherein the organic acid is not the octadecanoic acid; The octadecanoic acid is selected from 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid and mixtures thereof, and is preferably not stearic acid.

2. The composition of claim 1, wherein the octadecanoic acid is selected from the group consisting of 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, and mixtures thereof.

3. The composition of claim 1 or 2, wherein the composition comprises octadecanoic acid in an amount of 0.15 to 1 wt%, preferably 0.15 to 0.5 wt%.

4. The composition of claim 3, wherein the composition comprises an organic acid having a pKa in the range of 2.5 to 4.9 in an amount of 0.5 to 3 wt%.

5. The composition of any one of claims 1 to 4, wherein the octadecanoic acid is 12-hydroxystearic acid.

6. The composition of any one of claims 1 to 5, wherein the organic acid with a pKa in the range of 2.5 to 4.9 is selected from lactic acid, citric acid, glycolic acid, benzoic acid, caprylic acid, succinic acid, salicylic acid, butyric acid, phenylpropionic acid and mixtures thereof.

7. The composition of any one of claims 1 to 6, wherein the organic acid with a pKa in the range of 2.5 to 4.9 is selected from lactic acid, glycolic acid, benzoic acid and mixtures thereof.

8. The composition of any one of claims 1 to 7, wherein the organic acid having a pKa in the range of 2.5 to 4.9 is benzoic acid.

9. The composition of any one of claims 1 to 8, wherein the composition further comprises 1 to 20 wt% of an anionic surfactant selected from the group consisting of alkyl sulfates, alkyl ether sulfates, alpha olefin sulfonates, and mixtures thereof.

10. The composition of claim 10, wherein the anionic surfactant is selected from the group consisting of alkyl sulfates, alkyl ether sulfates, and mixtures thereof.

11. The composition of any one of claims 1 to 10, wherein the composition further comprises 1 to 5 wt% of an amphoteric surfactant.

12. The composition of any one of claims 1 to 11, wherein the pH of the composition is in the range of 3 to 10, preferably 4 to 7.

13. A composition as claimed in any one of claims 1 to 12, wherein the composition does not contain soap.

14. A method for improving the deposition of octadecanoic acid, comprising the steps of: i. applying the composition of any one of claims 1 to 13 to a surface; and ii. at least partially removing said composition from said surface, wherein the step of removing the composition is performed within 5 minutes of the step of applying the composition to the surface; The octadecanoic acid is selected from 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid and mixtures thereof, and is preferably not stearic acid.

15. Use of an organic acid having a pKa in the range of 2.5 to 4.9 in a liquid cleaning composition comprising octadecanoic acid for improving the deposition of said octadecanoic acid on a surface, wherein said organic acid having a pKa in the range of 2.5 to 4.9 is an organic acid other than said octadecanoic acid; The octadecanoic acid is selected from 10-hydroxystearic acid, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid and mixtures thereof, and is preferably not stearic acid.

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