Slow-release composite powder for removing nitrite and preparation method thereof

Abstract

The invention relates to the field of medicines, and discloses slow-release composite powder for removing nitrite and a preparation method thereof, and the slow-release composite powder comprises the following raw materials: bovine bone collagen peptide, sorbitol, L-sodium ascorbate, L-alanine composite powder, vitamin E, earthworm protein, natto powder, cranberry powder and magnesium stearate. Wherein the L-alanine composite powder is prepared from L-alanine, y-aminobutyric acid and L-glutamic acid; according to the present invention, the L-alanine composite powder and the active substance can chemically react with the nitrite in the body so as to convert the nitrite into the safe substance to be discharged out of the body, such that the absorption and the adsorption of the nitrite can be easily reduced, and the formation of the nitrite in the digestive tract can be reduced so as to reduce the concentration of the nitrite in the body; and nitrite is directly prevented from being accumulated to the level of potential health hazards.

Description

Technical Field

[0001] The invention relates to the field of medicine, and in particular to a sustained-release composite powder for removing nitrite and a preparation method thereof. Background Art

[0002] According to medical clinical research, nitrite has a certain degree of toxicity. Nitrite poisoning refers to poisoning caused by eating pickled meat products, pickles and spoiled vegetables with high nitrate or nitrite content, or mistakenly eating industrial sodium nitrite as table salt. It can also be seen after drinking bitter well water or steamer water containing nitrate or nitrite. Nitrite can oxidize the normal oxygen-carrying low-iron hemoglobin in the blood into high-iron hemoglobin, thereby losing its oxygen-carrying capacity and causing tissue hypoxia. Nitrite is a highly toxic substance. Ingestion of 0.2 to 0.5 grams in adults can cause poisoning, and 3 grams can be fatal.

[0003] As one of the common ingredients in food processing, nitrite plays an important role in preservation, but excessive intake may cause adverse effects on the human body, such as combining with amines to form carcinogens such as N-nitrosamines. Therefore, it is particularly important to develop a product that can effectively remove nitrite and is harmless to the human body. There are some attempts on the market, such as using tea tree "crab legs" polyphenol extract mixed with food materials and then heated to remove nitrite, but this is not directly applicable to the human body environment. In addition, studies have shown that phytic acid can replace nitrates and be added to sauce products to maintain color without harming health, but most of these methods focus on external application rather than internal regulation. Summary of the invention

[0004] The purpose of the present invention is to solve the above problems and to design a slow-release composite powder for removing nitrite and a preparation method thereof.

[0005] The present invention provides a slow-release composite powder for removing nitrite: The sustained-release composite powder comprises the following raw materials: Bovine collagen peptide, sorbitol, sodium L-ascorbate, L-alanine compound powder, vitamin E, earthworm protein, natto powder, cranberry powder, magnesium stearate; the L-alanine compound powder is composed of L-alanine, y-aminobutyric acid and L-glutamic acid.

[0006] The present invention also proposes a method for preparing a sustained-release composite powder for removing nitrite, comprising the following steps: Step S1: obtaining raw materials required for preparing sustained-release composite powder; Step S2: weighing the dry powder raw materials according to a predetermined ratio and adding them into a mixer for mixing to obtain a mixture; Step S3: preparing powder particles by wet granulation of the mixture; Step S4: placing the wet granules into a dryer for drying to obtain a sustained-release composite powder; Step S5: Pack the sustained-release composite powder into a sealed bottle and affix a label indicating the product name, ingredients, instructions for use, and shelf life information.

[0007] Furthermore, in the above method for preparing a sustained-release composite powder for removing nitrite, the dry powder raw materials are weighed according to a predetermined ratio and then added into a mixer for mixing in step S2, comprising: Arrange the amount of each ingredient and arrange them in order according to the capacity of the mixing container and the fill factor of 0.6-0.7; Preheat and check the mixer to ensure that the measuring system and timing device are working properly; Add the weighed raw materials into the mixer in the pre-set order for mixing.

[0008] Furthermore, in the above method for preparing a sustained-release composite powder for removing nitrite, the step S3 adopts wet granulation to prepare powder particles, comprising: Spray an appropriate amount of water or bonding solution onto the mixed mixture; Powder particles of the required size are made by extrusion and spheronization.

[0009] Furthermore, in the above method for preparing a sustained-release composite powder for removing nitrite, the step S4 of placing in an oven for drying comprises: After the fluid bed dryer is preheated, gradually add the powder particles to be dried; The powder particles are transported to the throwing feeder by a belt conveyor and then thrown evenly into the fluidized bed; The dryer parameters are set and drying is performed to obtain a slow-release composite powder.

[0010] Furthermore, in the above method for preparing a sustained-release composite powder for removing nitrite, the sustained-release composite powder is packaged into a sealed bottle in step S5, comprising: Weigh the sustained-release composite powder and fill it into a sealed bottle according to the capacity of the sealed bottle, which is a high-density polyethylene plastic bottle; The filled sealed bottles are sealed with a sealing machine.

[0011] The beneficial effect lies in that the sustained-release composite powder for removing nitrite of the present invention comprises the following raw materials: bovine collagen peptide, sorbitol, sodium L-ascorbate, L-alanine composite powder, vitamin E, earthworm protein, natto powder, cranberry powder, and magnesium stearate; wherein the L-alanine composite powder is composed of L-alanine, y-aminobutyric acid, and L-glutamic acid; the L-alanine composite powder and active substances can chemically react with nitrite in the body to convert it into a very safe substance and excrete it out of the body, which helps to reduce the absorption and adsorption of nitrite, and reduces the formation of nitrite in the digestive tract, thereby reducing its concentration in the body, which directly helps to prevent nitrite from accumulating to a level that poses a health hazard. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the following detailed description of the preferred embodiment.The drawings are only for the purpose of illustrating the preferred embodiments and are not to be construed as limiting the invention.

[0013] Figure 1 The present invention provides a flowchart of a method for preparing a sustained-release composite powder for removing nitrite according to an embodiment of the present invention. DETAILED DESCRIPTION

[0014] The embodiments of the present invention are described in detail below. Unless otherwise specified, all scientific and technological terms used in the present invention have the same meaning as those generally understood by those skilled in the art to which the present invention belongs. All patents and publications to which the present invention relates are incorporated herein by reference in their entirety. The term "comprising" or "including" is an open expression, i.e., including the contents specified in the present invention, but does not exclude the contents of other aspects.

[0015] For ease of understanding, the specific process of an embodiment of the present invention is described below. A sustained-release composite powder for removing nitrite includes the following raw materials: Bovine collagen peptide, sorbitol, sodium L-ascorbate, L-alanine compound powder, vitamin E, earthworm protein, natto powder, cranberry powder, magnesium stearate; the L-alanine compound powder is composed of L-alanine, y-aminobutyric acid and L-glutamic acid.

[0016] Specifically, bovine collagen peptides are derived from natural bovine bones and are carefully made through high-tech extraction and enzymatic hydrolysis processes. They are small molecule peptide substances that are easily absorbed and utilized by the human body. They are rich in a variety of essential amino acids, such as lysine and arginine, which are essential for maintaining human health. In terms of immune regulation, it is rich in amino acids, which are important material bases for the synthesis and activity of immune cells. Appropriate intake of bovine collagen peptides can enhance the body's immunity, enhance resistance, and reduce the occurrence of diseases. Bovine collagen peptides have a good ability to scavenge free radicals and can protect cells from oxidative damage. This helps to slow down the aging process and maintain the health and youthfulness of the body. Bovine collagen peptides also have a certain antibacterial effect, which helps to maintain the body's microecological balance.

[0017] It can also lower blood pressure and promote heart health by inhibiting the activity of angiotensin-converting enzyme (ACE).

[0018] Sodium L-ascorbate, also known as sodium ascorbate or sodium vitamin C, is an important water-soluble vitamin C derivative. It appears as white to slightly yellowish white crystalline powder or granules, is odorless and slightly salty, and is easily soluble in water. Sodium L-ascorbate has many important physiological functions in the human body and has significant benefits for human health. First, sodium L-ascorbate is a powerful antioxidant that can capture free radicals and prevent them from damaging molecules inside the body, thereby protecting cells and tissues from oxidative stress. This property makes sodium L-ascorbate play an important role in preventing cardiovascular and cerebrovascular diseases and delaying aging. Secondly, sodium L-ascorbate can enhance human immunity. It can promote the proliferation and generation of lymphocytes and improve the function of the body's immune system, thereby helping to prevent infection and disease. It is of great significance to improve the body's resistance and maintain a healthy state. In addition, sodium L-ascorbate is also involved in a variety of metabolic processes in the body, such as promoting the synthesis of collagen and improving iron absorption. These effects help maintain the normal structure and function of tissues such as skin, bones, and joints, and prevent the occurrence of diseases such as anemia.

[0019] L-alanine plays an important role in the critical care of heart, brain, and liver diseases. In patients with heart, brain, and liver diseases, L-alanine can be used to stabilize blood pressure and assist in stabilizing blood sugar, as well as for cardiotonic treatment of patients with heart failure. It helps maintain the normal rhythm of the heart, reduces the burden on the heart, and provides support in cardiovascular emergencies to help patients recover quickly. Secondly, L-alanine is also known as a powerful nutritional supplement that helps increase body energy and immune system enhancement. It is also an important component of protein synthesis in the body, which helps maintain tissue health and repair. Thirdly, L-alanine has a significant effect on the protection and improvement of the nervous system. It can effectively inhibit the excitability of the central nervous system, has a calming and tranquilizing effect, and has a miraculous effect on insomnia caused by neurasthenia. Finally, L-alanine also has a positive effect on the circulatory system. It can soften blood vessels, increase the elasticity of blood vessels, and increase the blood supply to the heart and brain.

[0020] Earthworm protein is a bioactive substance extracted from earthworms. It is rich in collagenase, plasmin, lumbrokinase, fibrinolytic activator and other ingredients. Its molecular weight is between 5000-10000. It is a short-chain small molecule substance that can smoothly enter the microvessels. It has a significant thrombolytic effect. The plasmin and lumbrokinase in earthworm protein can directly dissolve the fibrin formed by human thrombosis. Whether it is fresh thrombus or old thrombus, it can be effectively dissolved, thereby improving the body's own anticoagulant function. Secondly, earthworm protein can improve microcirculation. It can dissolve microthrombi in microvessels and restore the elasticity of hardened microvessels, thereby relieving the blockage and distortion of microvessels and making blood circulation smoother. Earthworm protein also has the function of regulating blood pressure and lowering blood sugar. It can help hypertensive patients stabilize their blood pressure levels by restoring blood elasticity, reducing peripheral blood flow resistance and blood viscosity. At the same time, it can also improve the internal environment, promote the recovery of pancreatic islet function, and has a certain positive effect on lowering blood sugar.

[0021] Magnesium stearate plays a vital role as a lubricant in pharmaceutical production excipients. It is a white, light and non-sandy fine powder that feels greasy when in contact with the skin, making it an indispensable lubricant in pharmaceutical production. In the process of drug preparation, magnesium stearate can significantly reduce the friction coefficient between drug particles, making the drug smoother in process steps such as mixing and pressing. It can form a lubricating film on the surface of drug particles, effectively blocking direct contact between materials, thereby avoiding heat and wear caused by friction, and ensuring the quality and stability of the drug. Magnesium stearate also has good anti-stick properties. In the preparation of drug tablets, it can prevent tablets or capsules from sticking to equipment during the production process, improving production efficiency. At the same time, the lubricating effect of magnesium stearate also helps the dissolution and release of drugs in the body, allowing the drugs to exert their therapeutic effects faster.

[0022] like Figure 1 As shown, a flow chart of a method for preparing a sustained-release composite powder for removing nitrite provided by an embodiment of the present invention, the method specifically comprises the following steps: Step S1: obtaining raw materials required for preparing sustained-release composite powder; Step S2: weighing the dry powder raw materials according to a predetermined ratio and adding them into a mixer for mixing to obtain a mixture; Step S3: preparing powder particles by wet granulation of the mixture; Step S4: placing the wet granules into a dryer for drying to obtain a sustained-release composite powder; Step S5: Pack the sustained-release composite powder into a sealed bottle and affix a label indicating the product name, ingredients, instructions for use, and shelf life information.

[0023] In this embodiment, in step S2, the dry powder raw materials are weighed according to a predetermined ratio and added to the mixer for mixing, which includes the following processes: according to the capacity of the mixing container and the filling factor of 0.6-0.7, the amount of each ingredient is arranged and arranged in order; preheating and checking the mixer to ensure that the measuring system and the timing device are working properly; and the weighed raw materials are added to the mixer in sequence according to the pre-set adding order for mixing.

[0024] Specifically, if the raw material particles are large or uneven, they need to be broken into finer particles by mechanical crushing; then screening operations are performed to remove large particles that do not meet the particle size requirements to ensure the consistency and uniformity of subsequent processes. Use a high-precision electronic balance to accurately weigh the weight of each raw material to ensure that it meets the requirements of the formula design. Add the weighed raw materials to the mixer in sequence according to the pre-set feeding order. Usually, a large amount of basic materials are added first, and then a smaller amount of functional auxiliary materials are gradually added, and finally the ingredients that are easy to fly or adhere are added. At the beginning of mixing, different types of mixed powders begin to move under the action of external forces. These forces come from the forces brought by the movement of the equipment or the gravity of the powder itself. As the mixing equipment continues to operate, the particles continue to be subjected to the mechanical force provided by the equipment, their own gravity, and the pressure or shear force of other particles. With the expansion of the powder, the movement of the particles in the mixing barrel, the relative position of the particles is redistributed, and finally the required mixing degree is achieved. After the mixing is completed, samples are taken to analyze the uniformity of the mixture. Common methods include visual inspection, microscopic observation, and chemical analysis. Ensure that the content of each component in each sample is consistent to achieve the expected mixing effect.

[0025] In this embodiment, wet granulation is used in step S3 to prepare powder particles, including the following processes: spraying an appropriate amount of water or binding solution onto the mixed mixture; and preparing powder particles of a desired size by extrusion and spheronization.

[0026] Specifically, high-speed shear granulators are widely used in production practice because they can complete the mixing, kneading and granulation processes in one container. For high-shear wet granulation, parameters such as the speed of the stirring blade, the speed of the cutting knife and the granulation time are usually set to ensure that the obtained particles have the appropriate size and shape. For example, when the granulating knife speed is slow, the particle size is larger; as the speed increases, the particle size will gradually decrease. Similarly, the speed of the stirring blade will also affect the size of the final particles.

[0027] In this embodiment, the drying process is carried out in an oven in step S4, which includes the following processes: after the fluidized bed dryer is preheated, the powder particles to be dried are gradually added; the powder particles are transported to the throwing feeder by a belt conveyor, and then thrown into the fluidized bed evenly; the dryer parameters are set, and the drying process is carried out to obtain a sustained-release composite powder.

[0028] Specifically, after the fluidized bed dryer is preheated and the internal temperature of the equipment is reached, the powder particles to be dried are gradually added; at this time, the powder particles are smoothly transported to the throwing feeder by a belt conveyor, and the throwing feeder ensures that the materials can be evenly dispersed and thrown into the fluidized bed at an appropriate speed and method. Next, the operating parameters of the dryer are set according to the specific process requirements and material characteristics, such as key indicators such as inlet air temperature and humidity (for example, t=80℃, RH=20%), gas velocity, bed pressure drop, etc., and then the drying program is started. During this period, hot air passes through the gas distribution plate from below to suspend the material particles to form a fluidized state, and at the same time, a strong heat exchange occurs with the material to cause the water to evaporate quickly. During the entire drying process, it is necessary to closely monitor the changes in various operating parameters, such as bed temperature, pressure difference, outlet exhaust humidity, etc., and make corresponding adjustments in time to ensure that the drying process is always in the best state. Finally, the sustained-release composite powder that has been fully dried is continuously discharged from the overflow port. In order to recover the fine particles that may be carried out with the exhaust gas, a cyclone separator or other form of dust removal device is usually installed at the end of the exhaust pipe. The purified exhaust gas is discharged into the atmosphere, and the recovered materials are returned to the product flow.

[0029] In this embodiment, the sustained-release composite powder is packaged into a sealed bottle in step S4, which includes the following processes: weighing the sustained-release composite powder and filling the sealed bottle according to the capacity of the sealed bottle, which is a high-density polyethylene plastic bottle; and sealing the filled sealed bottle with a sealing machine.

[0030] Specifically, after the preparation of the sustained-release composite powder is completed, a certain amount of the sustained-release composite powder needs to be accurately weighed first, and the weight of each filling is determined according to the specific capacity of the high-density polyethylene (HDPE) sealed bottle. In order to ensure the filling accuracy and efficiency, the weight filling technology can be used. Compared with the volumetric method, this method has the advantages of higher accuracy and easy calibration, and can also improve statistical process control and traceability. Before preparing for filling, for disposable HDPE plastic bottles, usually only sterile water spraying is required to meet the hygiene requirements. Then the weighed sustained-release composite powder is poured into the prepared HDPE sealed bottle through a specially designed filling device. After waiting for the filling to be completed, the sealed bottle is immediately sealed with a sealing machine. The operating principle of the sealing machine is to heat the upper and lower heating blocks to a predetermined temperature through an electric heating element, and apply appropriate pressure to make the bottle cap fit tightly to the bottle mouth, and finally obtain the finished product.

[0031] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A sustained-release composite powder for removing nitrite, characterized in that: The sustained-release composite powder comprises the following raw materials: Bovine collagen peptide, sorbitol, sodium L-ascorbate, L-alanine compound powder, vitamin E, earthworm protein, natto powder, cranberry powder, magnesium stearate; The L-alanine compound powder is composed of L-alanine, y-aminobutyric acid and L-glutamic acid.

2. A method for preparing the sustained-release composite powder for removing nitrite as claimed in claim 1, characterized in that: The following steps are involved: Step S1: obtaining raw materials required for preparing sustained-release composite powder; Step S2: weighing the dry powder raw materials according to a predetermined ratio and adding them into a mixer for mixing to obtain a mixture; Step S3: preparing powder particles by wet granulation of the mixture; Step S4: placing the wet granules into a dryer for drying to obtain a sustained-release composite powder; Step S5: Pack the sustained-release composite powder into a sealed bottle and affix a label indicating the product name, ingredients, instructions for use, and shelf life information.

3. The method for preparing the sustained-release composite powder for removing nitrite according to claim 2, characterized in that: In step S2, the dry powder raw materials are weighed according to a predetermined ratio and added into a mixer for mixing, comprising: Arrange the amount of each ingredient and arrange them in order according to the capacity of the mixing container and the fill factor of 0.6-0.7; Preheat and check the mixer to ensure that the measuring system and timing device are working properly; Add the weighed raw materials into the mixer in the pre-set order for mixing.

4. The method for preparing the sustained-release composite powder for removing nitrite according to claim 2, characterized in that: The step S3 adopts wet granulation to prepare powder particles, including: Spray an appropriate amount of water or bonding solution onto the mixed mixture; Powder particles of the required size are made by extrusion and spheronization.

5. The method for preparing the sustained-release composite powder for removing nitrite according to claim 2, characterized in that: The step S4 of placing the mixture in an oven for drying comprises: After the fluid bed dryer is preheated, gradually add the powder particles to be dried; The powder particles are transported to the throwing feeder by a belt conveyor and then thrown evenly into the fluidized bed; The dryer parameters are set and drying is performed to obtain a slow-release composite powder.

6. The method for preparing the sustained-release composite powder for removing nitrite according to claim 2, characterized in that: The step S5 of packaging the sustained-release composite powder into a sealed bottle comprises: Weigh the sustained-release composite powder and fill it into a sealed bottle according to the capacity of the sealed bottle, which is a high-density polyethylene plastic bottle; The filled sealed bottles are sealed with a sealing machine.

Images