Locking and holding device

Abstract

The present invention provides a locking and holding device, comprising a base, a locking member rotatably connected to the base, a holding member movably arranged on the base, and an elastic member located between the holding member and the base. The locking member has a self-locking section, and the holding member has a self-locking inclined surface that cooperates with the self-locking section. The locking member is actuated to rotate relative to the base in a direction away from the self-locking inclined surface to a locked state, and the first position of the self-locking section is disengaged from the abutment of the self-locking inclined surface; under the action of the elastic member, the holding member moves on the base until the self-locking inclined surface abuts and remains in the second position of the self-locking section; wherein the curvature radius of the first position is greater than the curvature radius of the second position. The locking and holding device provided by the present invention has a self-locking function, which can ensure that the locking member remains in a locked state for a long time, thereby ensuring the long-term stability and effectiveness of the locking and holding device under continuous heart beating, and helping to maintain the therapeutic effect of the operation.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a locking and retaining device. Background Art

[0002] The heart is the driving organ of blood circulation. It relies on rhythmic beating to push blood to continuously flow in the blood vessels. The atrioventricular valves (mitral valve and tricuspid valve) of the heart are one-way valves between the atria and ventricles, which are used to control the directional and efficient flow of blood from the atria to the ventricles, while preventing blood from flowing from the ventricles to the atria. When the atria contract, the atrioventricular valves open and blood flows from the atria to the ventricles; when the ventricles contract, the atrioventricular valves close to prevent blood from flowing back into the atria. However, when the leaflets, chordae tendineae, or valve rings of the atrioventricular valves and other related structures are diseased, the atrioventricular valves will not be able to close completely, causing blood to flow back into the atria, thereby triggering a series of pathological and physiological diseases.

[0003] Clinically, the repair techniques for heart valve diseases include surgical operations and minimally invasive interventional operations, and these operations generally require implants to be placed inside the heart and kept in a certain state for a long time. Taking chordal repair surgery as an example, generally, one end of the suture needs to be fixed to the leaflet of the heart valve, and the other end of the suture needs to be fixed to the ventricular tissue to serve as an artificial chordal tendon; at this time, a locking device can be used to lock one end of the suture to achieve long-term fixation. However, when the locking device in the prior art is in a locked state, in order to resist long-term heart beating, it is extremely difficult for the locking device to remain in a locked state for a long time, and there is a risk of locking failure. That is, in the prior art, the long-term stability and effectiveness of the locking device are extremely difficult to guarantee, and therefore it is difficult to maintain the therapeutic effect of the surgery. Summary of the Invention

[0004] The purpose of the present invention is to provide a locking and holding device with a self-locking function to ensure the long-term stability and effectiveness of the locking and holding device under continuous heart beating, which helps to maintain the therapeutic effect of the operation.

[0005] In order to achieve the above object, the present invention provides a locking and holding device, comprising:

[0006] matrix;

[0007] a locking member, the locking member being rotatably connected to the base, the locking member having a self-locking section;

[0008] a retaining member, the retaining member being movably disposed on the base, the retaining member having a self-locking inclined surface cooperating with the self-locking section; and

[0009] an elastic member, the elastic member being located between the retaining member and the base;

[0010] The locking member is actuated to rotate relative to the base in a direction away from the self-locking inclined surface to a locked state, and the first position of the self-locking section is disengaged from the abutment of the self-locking inclined surface; under the action of the elastic member, the retaining member moves on the base until the self-locking inclined surface abuts and remains in the second position of the self-locking section; wherein the curvature radius of the first position is greater than the curvature radius of the second position.

[0011] In the locking and retaining device provided by the present invention, in the locked state, the second position of the self-locking section of the locking member abuts the self-locking inclined surface of the retaining member. Under the dual action of the elastic thrust of the elastic member and the friction between the retaining member and the base, the retaining member can be prevented from moving on the base toward the elastic member, thereby ensuring that the self-locking inclined surface and the second position of the self-locking section can maintain abutment for a long time, ultimately ensuring that the locking member can remain in the locked state for a long time. In other words, the self-locking function of the locking and retaining device provides long-term resistance to the locking member's reverse rotation, thereby resisting long-term heartbeats, thereby ensuring the long-term stability and effectiveness of the locking and retaining device and helping to maintain the therapeutic effect of the surgery. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0013] Figure 1 It is a schematic diagram of the three-dimensional structure of the locking and holding device provided in the first embodiment of the present invention.

[0014] Figure 2 yes Figure 1 A partially exploded schematic diagram of the locking and retaining device shown.

[0015] Figure 3 yes Figure 2 The locking and holding device shown is an exploded schematic diagram from another perspective after omitting the anchoring member.

[0016] Figure 4 yes Figure 1 The locking and holding device is shown as a cross-sectional view when a suture is passed through the device and the self-locking section is in a first position abutting against the self-locking inclined surface.

[0017] Figure 5 yes Figure 1 The locking protection device is shown as a cross-sectional view when a suture is passed through the device and the second position of the self-locking section abuts against the self-locking inclined surface.

[0018] Figure 6A yes Figure 4 The diagram shows the forces between the locking member, the retaining member and the base when the locking and retaining device is in the initial state.

[0019] Figure 6B yes Figure 5 The diagram shows the forces between the locking member, the retaining member and the base when the locking and retaining device is in the locked state.

[0020] Figure 7 yes Figure 3 Schematic diagram of the three-dimensional structure of the substrate shown.

[0021] Figure 8 yes Figure 7 A schematic diagram of the three-dimensional structure of the substrate shown in another perspective.

[0022] Figure 9 yes Figure 3 Schematic diagram of the three-dimensional structure of the locking member shown.

[0023] Figure 10 yes Figure 3 Schematic diagram of the three-dimensional structure of the retaining member shown.

[0024] Figure 11 It is a schematic diagram of the three-dimensional structure of the retaining member in another embodiment.

[0025] Figure 12 yes Figure 4 Schematic diagram of the locking and holding device shown, which is threaded with sutures and movably connected to the actuator and the driver.

[0026] Figure 13 It is a schematic diagram of the three-dimensional structure of the anchoring member under another embodiment.

[0027] Figures 14 to 18 This is a schematic diagram of the use of the locking and retaining device of the first embodiment for locking sutures in artificial chordae tendineae implantation, wherein: Figure 15 yes Figure 14 An enlarged schematic diagram of section XV is shown.

[0028] Figure 19 It is a schematic diagram of the three-dimensional structure of the locking and holding device provided in the second embodiment of the present invention.

[0029] Figure 20 yes Figure 19 A perspective exploded schematic diagram of the locking and holding device shown.

[0030] Figure 21 yes Figure 20 Schematic diagram of the three-dimensional structure of the base shown.

[0031] Figure 22 yes Figure 21A schematic diagram of the three-dimensional structure of the base shown in another perspective.

[0032] Figure 23 yes Figure 20 Schematic diagram of the three-dimensional structure of the shell shown.

[0033] Figure 24 yes Figure 20 Schematic diagram of the three-dimensional structure of the locking member shown.

[0034] Figure 25 yes Figure 19 The locking and holding device is shown as a cross-sectional view when a suture is passed through the device and the self-locking section is in a first position abutting against the self-locking inclined surface.

[0035] Figure 26 yes Figure 19 The locking protection device is shown as a cross-sectional view when a suture is passed through the device and the second position of the self-locking section abuts against the self-locking inclined surface.

[0036] Figures 27 to 29 Schematic diagram of the use of the locking and retaining device of the second embodiment for locking sutures in transcatheter mitral valve edge-to-edge repair, wherein: Figure 28 yes Figure 27 An enlarged schematic diagram of section XXVIII is shown.

[0037] Description of main reference numerals:

[0038] Locking and holding device 1000; suture 2000; delivery device 3000; base 1; main body 11; guide surface 111; protrusion 112; insertion hole 113; first end plate 12; guide groove 121; guide hole 122; positioning groove 123; support portion 13; first through hole 131; extension portion 14; second thread hole 141; engaging portion 15; base 16; base body 161; second end plate 162; third end plate 163; second traction hole 164; third traction hole 165; first positioning structure 166; housing 17; avoidance groove-171; second positioning structure-172; third through hole-173; locking member-2; self-locking section-21; second through hole-22; first wire hole-23; first traction hole-24; retaining member-3; self-locking inclined surface-31; wedge block-32; guide column-33; elastic member-4; open end-41; bent end-42; insertion hole-421; connecting shaft-5; anchor member-6; plug-in part-63; push rod-3100; release rod-3200; anchor sheath tube-3300; traction rope-3400; delivery sheath tube-3500; first position-A; second position-B.

[0039] The following specific embodiments will further illustrate the present invention in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0040] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0041] In addition, the following descriptions of the embodiments refer to the accompanying drawings to illustrate specific embodiments in which the present invention may be implemented. Directional terms mentioned in the present invention, such as "upper," "lower," "front," "back," "left," "right," "inner," "outer," and "side," are merely references to the directions in the accompanying drawings. Therefore, the directional terms used are intended to better and more clearly illustrate and understand the present invention, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, be constructed, or operate in a specific orientation. Therefore, they should not be construed as limitations on the present invention.

[0042] It should be noted that, to more clearly describe the structure of the locking and retaining device provided by the present invention, the defined terms "proximal end" and "distal end" used in this specification are commonly used in the field of interventional medicine. Specifically, "distal end" refers to the end away from the operator during a surgical procedure, while "proximal end" refers to the end closer to the operator during a surgical procedure. The axial direction is defined as the direction of the central axis of rotation of an object such as a cylinder or a tube; the circumferential direction is the direction around the axis of the object such as a cylinder or a tube (perpendicular to the axis and also perpendicular to the cross-sectional radius); and the radial direction is the direction along the diameter or radius. It is worth noting that the "end" in terms such as "proximal end," "distal end," "one end," "other end," "first end," "second end," "initial end," "terminal end," "both ends," "free end," "upper end," and "lower end" is not limited to the end, endpoint, or end face, but also includes the portion extending an axial distance and / or radial distance from the end, endpoint, or end face on the component to which the end, endpoint, or end face belongs. Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by those skilled in the art to which this invention belongs. The conventional terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not to be construed as limiting the present invention.

[0043] Please combine Figures 1 to 5 An embodiment of the present invention provides a locking and holding device 1000 with a self-locking function to ensure the long-term stability and effectiveness of the locking and holding device 1000 under continuous heart beating, which helps to maintain the therapeutic effect of the surgery.

[0044] Specifically, such as Figures 1 to 3As shown, in an embodiment of the present invention, the locking and holding device 1000 includes a base 1, a locking member 2 rotatably connected to the base 1, a holding member 3 movably provided on the base 1, and an elastic member 4 located between the holding member 3 and the base 1. Figure 4 and Figure 5 As shown, the locking member 2 has a self-locking section 21 (i.e., the arc-shaped outer surface of the locking member 2 that is rotatably connected to one end of the base 1), and the retaining member 3 has a self-locking inclined surface 31 that cooperates with the self-locking section 21 (i.e., the inclined surface of the retaining member 3 that faces and abuts against the locking member 2). The elastic member 4 is compressed and arranged between the retaining member 3 and the base 1, and is used to provide an elastic thrust to push the retaining member 3, so that the self-locking inclined surface 31 of the retaining member 3 always abuts and cooperates with the self-locking section 21 of the locking member 2, and the self-locking inclined surface 31 abuts at different positions of the self-locking section 21 when the locking member 2 is in different states. Specifically, as Figure 4 As shown, the locking member 2 is in the initial state, and the self-locking inclined surface 31 abuts against the first position A of the self-locking section 21; Figure 5 As shown, the locking member 2 is in a locked state, and the self-locking inclined surface 31 abuts against the second position B of the self-locking section 21 , wherein the curvature radius of the self-locking section 21 at the first position A is greater than the curvature radius at the second position B.

[0045] Please combine again Figure 4 and Figure 5 In the embodiment of the present invention, the locking member 2 can be in the actuator (not limited to Figure 4 The push rod 3100 shown in the figure is actuated to rotate relative to the base 1, and the locking member 2 in the initial state is actuated to rotate relative to the base 1 in a direction away from the self-locking inclined surface 31, and the first position A of the self-locking section 21 is disengaged from the abutment of the self-locking inclined surface 31. Under the action of the elastic member 4, the retaining member 3 moves on the base 1 until the self-locking inclined surface 31 abuts and remains in the second position B of the self-locking section 21. At this time, the locking member 2 is switched from the initial state to the locked state. It is easy to understand that the rotation axis of the locking member 2 is fixed relative to the base 1, and the curvature radius of the self-locking section 21 in the first position A is greater than the curvature radius in the second position B. Therefore, after the self-locking inclined surface 31 is separated from the first position A of the self-locking section 21, a gap is formed between the self-locking section 21 and the self-locking inclined surface 31. The elastic member 4 pushes the retaining member 3 on the base 1 toward the locking member 2, thereby causing the self-locking inclined surface 31 to abut against the second position B of the self-locking section 21. This means that when the locking member 2 is in different states, the self-locking inclined surface 31 abuts against different positions of the self-locking section 21, and the self-locking section 21 also abuts against different positions of the self-locking inclined surface 31. In some embodiments, the curvature radius of the self-locking section 21 in the first position A is the distance from the rotation axis of the locking member 2 to the first position A, and the curvature radius of the self-locking section 21 in the second position B is the distance from the rotation axis of the locking member 2 to the second position B.

[0046] like Figure 4 and Figure 5 As shown, when the locking and holding device 1000 provided by the embodiment of the present invention is applied to the locking of the suture 2000, the operator can first pass the suture 2000 between the base 1 and the locking member 2 in the initial state, and then actuate the locking member 2 to rotate to the locked state relative to the base 1. The locking member 2 in the locked state is configured to press the suture 2000 located between the base 1 and the locking member 2, thereby achieving the locking of the suture 2000; furthermore, the second position B of the self-locking section 21 of the locking member 2 in the locked state abuts against the self-locking inclined surface 31 of the retaining member 3, and the elastic thrust of the elastic member 4 is Under the dual action of the friction between the retaining member 3 and the base 1, the retaining member 3 can be prevented from moving on the base 1 in the direction away from the locking member 2, thereby ensuring that the self-locking bevel 31 remains in contact with the second position B of the self-locking section 21, and preventing the locking member 2 from rotating in the opposite direction relative to the base 1, such as rotating in the direction close to the self-locking bevel 31, thereby realizing the self-locking function of the locking member 2, so that the locking member 2 in the locked state can always press the suture 2000, thereby resisting long-term heart beating, preventing the suture 2000 from loosening, and helping to maintain the therapeutic effect of the surgery using the suture 2000.

[0047] Preferably, Figure 4 and Figure 5 As shown, in some embodiments of the present invention, the self-locking section 21 of the locking member 2 is an arc-shaped outer surface with a curvature radius gradually decreasing from the first position A to the second position B, and the contour line of the self-locking section 21 can be a section of an Archimedean spiral or a section of an involute. In this way, when the heart beats and drives the suture 2000 to react on the locking piece 2 in the locked state, the locking piece 2 tends to reverse in the direction close to the self-locking bevel 31, but since the curvature radius of the self-locking segment 21 gradually increases from the second position B to the first position A, the locking piece 2 with a reversal tendency will produce a greater extrusion force on the retaining piece 3, and the extrusion force further causes the retaining piece 3 to produce a greater force on the base 1, thereby increasing the friction between the base 1 and the retaining piece 3, and helping to prevent the retaining piece 3 from moving in the opposite direction on the base 1, so as to ensure that the self-locking bevel 31 and the second position B of the self-locking segment 21 continue to maintain contact, and avoid the locking piece 2 from rotating relative to the base 1 in the direction close to the self-locking bevel 31, thereby improving the reliability of the self-locking function of the locking piece 2 and preventing the suture 2000 from loosening.

[0048] See also Figure 6A and Figure 6B , Figure 6A FIG1 shows a schematic diagram of the forces between the locking member 2, the retaining member 3 and the base 1 of the locking and retaining device 1000 when the locking member 2 is in the initial state. Figure 6BFIG1 shows a schematic diagram of the forces between the locking member 2, the retaining member 3 and the base 1 of the locking and retaining device 1000 when the locking member 2 is in the locked state. Figure 6A as well as Figure 6B As shown, the base 1 has a guide surface 111, and the retaining member 3 is slidably disposed on the guide surface 111. The outline of the self-locking segment 21 of the locking member 2 is schematically represented by an Archimedean spiral. It should be noted that in this embodiment of the present invention, the friction coefficient of the self-locking inclined surface 31 is defined as μ1, the friction coefficient of the guide surface 111 is defined as μ2, and the angle between the self-locking inclined surface 31 and the guide surface 111 is defined as θ. The gravity of the locking member 2 and the retaining member 3 is negligible.

[0049] like Figure 6A As shown, when the locking member 2 is in its initial state, the first position A of the self-locking section 21 is maintained at the first position of the self-locking inclined surface 31. At this time, the retaining member 3 is subjected to the elastic force F1 of the elastic member 4 and has a tendency to move horizontally to the left. The retaining member 3 generates an initial preload force and squeezes the outer contour of the self-locking section 21 of the locking member 2. However, due to the joint support of the base 1 and the locking member 2, relative movement cannot occur. The outer contour of the self-locking section 21 is in line contact with the self-locking inclined surface 31 of the retaining member 3. A static analysis of the locking member 2 shows that due to the action of the elastic member 4, the locking member 2 is subjected to the pressure F provided by the retaining member 3 along the normal direction of the self-locking inclined surface 31. N , F N =F1*sinθ. The direction of the line between the rotation axis of the locking member 2 and the first position A and the pressure F N The angle between the directions is α, which is actually small. In this process, it is considered that F N Pointing to the rotation axis of the locking member 2. When the operator performs an operation to switch the locking member 2 from the initial state to the locked state, the retaining member 3 generates a force F' that is tangential to the outer contour of the self-locking section 21 of the locking member 2. At this time, a friction force f is also generated between the retaining member 3 and the locking member 2 to prevent the locking member 2 from rotating, where f = F N *μ1. It is easy to understand that when F'<f, the locking member 2 cannot rotate, and when the operator increases the force F' until F'>f, that is, F'>F1*sinθ*μ1, the locking member 2 is subjected to unbalanced force and rotates. During the rotation, because the outer contour of the self-locking section 21 of the locking member 2 is an arc-shaped outer surface with a gradually decreasing curvature, the retaining member 3 will move to the left under the push of the elastic member 4, and the elastic force F1 of the elastic member 4 will gradually decrease. The force F' exerted on the locking member 2 will cause the locking member 2 to rotate to a locked state of squeezing the suture 2000. At this time, the second position B of the self-locking section 21 abuts against the second position of the self-locking inclined surface 31 (see Figure 6B ).

[0050] like Figure 6BAs shown, when the locking member 2 is in the locked state, to ensure that the suture 2000 does not loosen, it is necessary to ensure that the locking member 2 does not rotate. The clockwise rotation of the locking member 2 is the thread loosening process. At this time, the retaining member 3 will hinder the clockwise rotation of the locking member 2, thereby achieving static equilibrium. Because the locking member 2 must not rotate, which is equivalent to the retaining member 3 not being displaced in the left and right directions shown in the figure, a static analysis of the retaining member 3 is performed. The total forces acting on the retaining member 3 include: the force (i.e., elastic force) F1 of the elastic member 4 on the retaining member 3, the force (i.e., pressure) F2 of the locking member 2 on the retaining member 3, the friction force f1 of the guide surface 111 on the retaining member 3, and the friction force f2 of the locking member 2 on the retaining member 3. Assuming that the direction of the friction force is horizontally positive and toward the left, when the self-locking inclined surface 31 abuts against the second position B of the self-locking section 21, the angle α between the direction of the line connecting the rotation axis of the locking member 2 and the second position B and the normal direction of the self-locking inclined surface 31 is α, and the retaining member 3 does not move in the left and right directions shown in the figure, that is, the sum of the component forces in the horizontal direction is zero, that is, the resultant force in the horizontal direction to the right is equal to the resultant force in the horizontal direction to the left. At this time, the above-mentioned various forces satisfy the following relationship:

[0051] Formula 1: F2*cosα*sinθ+F2*sinα*cosθ-f2*cosθ-f1-F1=0; that is, F2*cosα*sinθ+F2*sinα*cosθ (horizontal rightward force)=f2*cosθ+f1+F1 (horizontal leftward force)

[0052] Formula 2: f2=F2*μ1*cosα

[0053] Formula 3: f1=F2*μ2*cosθ*cosα

[0054] According to the above formula, we can obtain: tanθ+tanα=μ1+μ2+F1 / (F2*cosθ*cosα). Therefore, in order to prevent the holding member 3 from moving horizontally, the resultant force to the right must be less than or equal to the resultant force to the left, that is:

[0055] tanθ+tanα≤μ1+μ2+F1 / (F2*cosθ*cosα)

[0056] Under actual conditions, the angle α is very small, that is, tanα≈0, cosα≈1; and the friction coefficients μ1 and μ2 are related to the material and surface conditions. Substituting them into the above inequality yields the final inequality:

[0057] tanθ≤μ1+μ2+F1 / (F2*cosθ)

[0058] In the embodiment of the present invention, assuming that the materials used are ideal rigid bodies, the friction coefficient μ1 of the self-locking inclined surface 31, the friction coefficient μ2 of the guide surface 111, the elastic force F1 of the elastic member 4, the pressure F2 of the locking member 2 on the retaining member 3, and the value of the angle θ satisfy the above-mentioned final inequality, and the locking member 2 has a self-locking function. To ensure that the locking member 2 is self-locking after locking, the above-mentioned final inequality indicates that a smaller angle θ is more appropriate. However, considering that the materials used are not ideal rigid bodies, a smaller angle θ increases the likelihood of deformation of the retaining member 3, which in turn may cause the self-locking function of the locking member 2 to fail. Therefore, in the embodiment of the present invention, preferably, the angle θ between the self-locking inclined surface 31 and the guide surface 111 is less than or equal to 45 degrees, and more preferably 30 degrees.

[0059] It should be noted that, in embodiments of the present invention, the locking and retaining device 1000 further includes other components. For example, in some embodiments, the locking and retaining device 1000 further includes a connecting shaft 5 for rotatably connecting the locking member 2 to the base 1, and an anchoring member 6 for engaging target tissue (not limited to ventricular tissue). The specific structure of the locking and retaining device 1000 provided in embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0060] Please combine Figure 1 、 Figure 7 and Figure 8 In the first embodiment of the present invention, the base 1 includes a main body 11 having a substantially rectangular parallelepiped structure, a first end plate 12 connected to one end of the main body 11 near the elastic member 4, and a pair of support portions 13 connected to the outer peripheral wall of the first end plate 12 and extending along the length direction of the main body 11 toward the locking member 2. Figure 1 、 Figure 7 and Figure 8 As shown, the side of the main body 11 facing the locking member 2 has a guide sliding surface 111 for movably setting the retaining member 3, and the first end plate 12 includes a first plate body that is roughly semicircular, and a second plate body that is rectangular and connected to one side of the first plate body. The first plate body covers the end of the main body 11 and the outer peripheral wall exceeds the end of the main body 11. The second plate body is connected to the side of the first plate body adjacent to the guide sliding surface 111. A pair of support portions 13 are connected to the outer peripheral wall of the first plate body and are spaced apart on opposite sides of the width direction of the main body 11. Each support portion 13 exceeds the guide sliding surface 111 of the main body 11. Among them, the main body 11, the first end plate 12 and the pair of support portions 13 jointly define a receiving space located on one side of the guide sliding surface 111. The locking member 2, the retaining member 3 and the elastic member 4 are all arranged in the receiving space (see Figure 1 ).

[0061] See also Figure 9In the first embodiment of the present invention, the locking member 2 is roughly in the shape of a rectangular block, and its two opposite ends in the length direction are respectively a free end and a transfer end, and the transfer end is provided with a self-locking section 21 and is used to be rotatably connected to the base 1. Figure 1 、 Figure 3 and Figure 9 In the first embodiment of the present invention, a first through hole 131 is defined at one end of each support portion 13, distal from the first end plate 12, along the width of the main body 11. A second through hole 22 is defined at the adapter end of the locking member 2. The locking and retaining device 1000 further includes a connecting shaft 5, which is inserted into the corresponding first and second through holes 131, 22, so that the locking member 2 is rotatably connected to the pair of support portions 13 of the base 1 about the connecting shaft 5. The connecting shaft 5 can be secured to the support portion 13 by threading, welding, or bonding, though welding is preferred for reliability.

[0062] In other embodiments, the locking member 2 may also be provided with a pair of connecting shafts protruding from opposite sides of the adapter end, and the pair of connecting shafts are correspondingly inserted into the pair of first through-holes 131 of the pair of support portions 13, so that the locking member 2 is rotatably connected to the pair of support portions 13 of the base 1 about the pair of connecting shafts, thereby eliminating the need for the connecting shaft 5 as a separate component and simplifying the structure of the locking and retaining device 1000. Of course, in other embodiments, each support portion 13 may also be provided with a connecting shaft protruding from the other support portion 13, and the two connecting shafts of the pair of support portions 13 are inserted into the second through-holes 22 of the locking member 2, similarly allowing the locking member 2 to be rotatably connected to the pair of support portions 13 of the base 1 about the pair of connecting shafts, thereby also eliminating the need for the connecting shaft 5 as a separate component and simplifying the structure of the locking and retaining device 1000.

[0063] Please combine Figure 1 、 Figure 3 、 Figure 10 and Figure 11 In the first embodiment of the present invention, the retaining member 3 includes a wedge block 32 and a guide post 33 connected to one end of the wedge block 32. The self-locking inclined surface 31 is provided on the wedge block 32 and faces away from the guide post 33. The elastic member 4 is sleeved on the guide post 33 and axially compressed between the wedge block 32 and the base 1. Specifically, in the first embodiment of the present invention, the elastic member 4 includes a spring with a U-shaped structure. The spring includes an open end 41 and a curved end 42 connected to the open end 41. The open end 41 abuts against the first end plate 12 of the base 1, and the curved end 42 abuts against the wedge block 32. The curved end 42 is provided with a through hole 421 for the guide post 33 to pass through. In other embodiments, the elastic member 4 may also be a spring. The spring is sleeved on the guide post 33 and compressed between the wedge block 32 and the first end plate 12 of the base 1, and can also push the retaining member 3.

[0064] Optional, such as Figure 10As shown, in one embodiment, the wedge block 32 is a block with a roughly L-shaped structure, and the self-locking inclined surface 31 extends from the side of the wedge block 32 away from the guide post 33 to the side close to the guide post 33. The end of the wedge block 32 close to the guide post 33 has a rectangular protrusion, as shown in FIG. Figure 4 As shown, the bent end 42 of the elastic member 4 abuts against the rectangular protrusion of the wedge block 32. The abutment area between the bent end 42 and the wedge block 32 is large, which helps to improve the stability of the elastic pushing effect of the elastic member 4 on the retaining member 3. Figure 11 As shown, in another embodiment, the wedge block 32 is a block with a roughly triangular prism structure, and the self-locking slope 31 extends from the side of the wedge block 32 away from the guide column 33 to the side close to the guide column 33. The wedge block 32 is small in size, which helps to reduce the overall mass of the locking and retaining device 1000.

[0065] Preferably, Figure 1 、 Figure 3 and Figure 8 As shown, in the first embodiment of the present invention, the base 1 is provided with a guide groove 121 extending axially (i.e., in the longitudinal direction of the main body 11), and the end of the guide post 33 away from the wedge block 32 is at least partially accommodated in the guide groove 121 and can move axially relative to the guide groove 121. In this embodiment, the guide post 33 is at least partially accommodated in the guide groove 121 and can move axially relative to the guide groove 121, which can limit the elastic member 4 to push the retaining member 3 to move axially along the guide sliding surface 111 of the base 1. Specifically, in Figure 1 、 Figure 3 and Figure 8 In the example, the guide groove 121 is opened on the side surface of the second plate of the first end plate 12 facing the elastic member 4. Preferably, the guide groove 121 penetrates the second plate, which reduces the difficulty of machining the guide groove 121 on the second plate. The end of the guide post 33 away from the wedge block 32 is exposed to the first end plate 12 through the guide groove 121. The shape of the axial cross section of the guide post 33, the shape of the through hole 421 and the shape of the guide groove 121 are adapted to each other, and can be, but not limited to, oval, circular, cross-shaped, etc. Figure 3 and Figure 8 In the example, the shape of the axial cross-section of the guide column 33, the shape of the through-hole 421 and the shape of the guide groove 121 are preferably oval, and the long axis direction of the oval extends along the width direction of the main body 11. In this way, it can be limited that the retaining member 3 will not move in the radial direction of the base 1 (i.e., the direction perpendicular to the guide sliding surface 111) when it moves on the guide sliding surface 111, which helps to improve the movement stability of the retaining member 3.

[0066] Preferably, Figure 1 and Figure 8As shown, in the first embodiment of the present invention, the base 1 is further provided with a positioning groove 123 for accommodating one end of the elastic member 4 that abuts against the base 1. Figure 1 and Figure 8 In the example, a positioning groove 123 is defined at the intersection of the second plate of the first end plate 12 facing the retaining member 3 and the pair of support portions 13. The open ends 41 of the elastic member 4 are correspondingly received in the two positioning grooves 123. In this embodiment, by defining the positioning grooves 123 on the base 1 to receive the open ends 41 of the elastic member 4, the elastic member 4 can be positioned, thereby helping to improve the stability of the elastic member 4 between the base 1 and the retaining member 3, thereby also improving the stability of the elastic member 4 in pushing against the retaining member 3.

[0067] Further, please combine Figure 3 、 Figure 4 and Figure 8 In the first embodiment of the present invention, the proximal end of the base 1 is further provided with a guide hole 122, the locking member 2 is provided with a driving surface (i.e. the surface of the free end of the locking member 2 close to the self-locking inclined surface 31), an actuator (i.e. Figure 4 The distal end of the push rod 3100 shown in FIG. 1 passes through the guide hole 122 and engages with the driving surface of the locking member 2 to actuate the locking member 2, so that the locking member 2 can rotate relative to the base 1 in a direction away from the self-locking inclined surface 31. Specifically, Figure 3 、 Figure 4 and Figure 8 In the example shown, the guide hole 122 is formed in the second plate body of the first end plate 12 and is located on the side of the guide groove 121 away from the guide surface 111. The shape of the guide hole 122 can be, but is not limited to, circular or elliptical, with a circular shape being preferred. It is understood that the push rod 3100 is movably disposed within the circular guide hole 122, with its distal end abutting the driving surface of the locking member 2. Distal axial movement of the push rod 3100 pushes the locking member 2 to rotate about the connecting shaft 5 away from the self-locking inclined surface 31.

[0068] Preferably, Figure 4 and Figure 9 As shown, in the first embodiment of the present invention, the side surface of the locking member 2 close to the self-locking inclined surface 31 is a concave arc surface, which helps to increase the abutment area between the distal end of the push rod 3100 and the driving surface of the locking member 2, thereby ensuring that the push rod 3100 can push the locking member 2 to rotate from the initial state to the locked state.

[0069] Please refer again Figure 4 and Figure 9In the first embodiment of the present invention, the locking member 2 is provided with a first thread hole 23 for passing the suture 2000. After passing through the first thread hole 23, the suture 2000 is located between the base 1 and the locking member 2 and can move toward the base 1 under the drive of the locking member 2 until it is pressed against the base 1 by the locking member 2. Specifically, Figure 4 and Figure 9 In the example shown in FIG, the first thread hole 23 is defined between the free end and the adapter end of the locking member 2, and the inner diameter of the first thread hole 23 is larger than the diameter of the suture 2000 to allow for free movement of the suture 2000. In this embodiment, by defining the first thread hole 23 in the locking member 2 for passing the suture 2000, radial movement of the suture 2000 along the base 1 can be restricted. When the suture 2000 is compressed between the locking member 2 and the base 1, axial movement of the suture 2000 along the base 1 can be restricted, thereby achieving locking of the suture 2000.

[0070] Preferably, Figure 4 and Figure 8 As shown, in the first embodiment of the present invention, an extension portion 14 extends radially (i.e., perpendicular to the guide surface 111) from one end of the base 1 (specifically, the main body 11) away from the elastic member 4. The extension portion 14 and the locking member 2 are located on the same side of the base 1. The extension portion 14 defines a second thread hole 141. The suture 2000 axially passes through the connected second thread hole 141 and the first thread hole 23 before exiting the locking and retaining device 1000. In this embodiment, the second thread hole 141, which connects to the first thread hole 23, is provided in the extension portion 14 of the base 1 to further restrict the radial movement of the suture 2000 along the base 1. Furthermore, the dual constraints of the second thread hole 141 and the first thread hole 23 ensure that the suture 2000 is partially located between the base 1 and the locking member 2, ensuring that the locking member 2 can compress the suture 2000 after rotation. The first thread hole 23 and the second thread hole 141 can be, but are not limited to, circular or elliptical holes, and this is not a limitation.

[0071] Preferably, Figure 5 and Figure 8 As shown, in the first embodiment of the present invention, the main body 11 of the base 1 may further be provided with a protrusion 112 at one end away from the elastic member 4. When the locking member 2 compresses the suture 2000, the protrusion 112 is at least partially received in the first thread-passing hole 23, and the protrusion 112 squeezes the suture 2000 passed through the first thread-passing hole 23. In this embodiment, by providing the protrusion 112 on the main body 11 to squeeze the suture 2000 passed through the first thread-passing hole 23, the squeezing area of ​​the locking and retaining device 1000 on the suture 2000 is increased, thereby helping to improve the locking reliability of the suture 2000.

[0072] Please refer again Figure 5 and Figure 8 In the first embodiment of the present invention, the extension portion 14 of the base 1, the protrusion 112 on the main body 11, and the portion of the main body 11 located between the extension portion 14 and the protrusion 112 together form a bearing structure that is generally in the form of a U-shaped groove. The bearing structure includes a first bearing surface located at the bottom of the U-shaped groove, a second bearing surface located on the side of the extension 14 facing the protrusion 112, and a third bearing surface located on the side of the protrusion 112 facing the extension 14. The first bearing surface, the second bearing surface, and the third bearing surface extend in three different directions. The angle between the first bearing surface and the second bearing surface is an acute angle ranging from 30 degrees to 90 degrees, preferably 60 degrees in the present invention; the angle between the first bearing surface and the third bearing surface is an obtuse angle, preferably 120 degrees in the present invention. The end of the locking member 2 and the portion away from the first wire hole 23 constitute a roughly U-shaped block-shaped wire pressing structure, which has a first wire pressing surface, a second wire pressing surface and a third wire pressing surface extending in three different directions. When the locking member 2 is in a locked state and the protrusion 112 is at least partially accommodated in the first wire hole 23, the first wire pressing surface, the second wire pressing surface and the third wire pressing surface of the wire pressing structure respectively correspond to the first bearing surface, the second bearing surface and the third bearing surface of the supporting structure. Under the joint action of the wire pressing structure and the supporting structure, the suture 2000 is compressed in a U shape between the locking member 2 and the base 1. The suture 2000 forms a U-shaped locking wire length, which can provide a larger locking force. Among them, the suture 2000 is compressed and deformed between the aforementioned wire pressing structure and the supporting structure. In order to ensure that the suture 2000 is compressed, preferably, the compression deformation amount L of the suture 2000 satisfies the relationship: 1 / 2*D<L<3 / 4*D, where D is the diameter of the suture 2000.

[0073] Please combine Figure 1 and Figure 12 In the first embodiment of the present invention, the proximal end of the base body 1 is provided with a joint portion 15, which is used to detachably connect a driver (for example Figure 12 The release lever 3200 shown in FIG. 3 is used to drive the locking and holding device 1000 to move. Specifically, Figure 1 and Figure 12 In the example shown, the engagement portion 15 is a connection hole formed in the first end plate 12 of the base body 1, and the actuator is a release lever 3200. The distal end of the release lever 3200 engages within the connection hole, thereby driving the locking and retaining device 1000 to move. In other embodiments, the engagement portion 15 may also be an internal or external thread extending axially along the base body 1, and the engagement portion 15 is threadedly connected to the release lever 3200. Of course, the engagement portion 15 may also be detachably connected to the release lever 3200 through other snap-fit ​​connection methods, which are not limited to this.

[0074] Further, please combine Figure 1 、 Figure 2 and Figure 13 In the first embodiment of the present invention, the locking and holding device 1000 further comprises an anchor 6 connected to the distal end of the base 1, and the anchor 6 is used to engage the target tissue (not limited to ventricular tissue). Figure 1 and Figure 2 As shown, in one embodiment, the anchor 6 can be a spiral anchor; Figure 13 As shown, the anchor 6 can be a barbed spring. Among them, the spiral anchor and the barbed spring can adopt the spiral anchor and the barbed spring in the prior art, which will not be described in detail. Figure 1 and Figure 2 In the example, the anchor 6 adopts a spiral anchor, and the proximal end of the spiral anchor is provided with a plug-in portion 63, and the distal end of the main body 11 of the base 1 is provided with a plug-in hole 113. The plug-in portion 63 of the spiral anchor is correspondingly plugged into the plug-in hole 113 of the main body 11, thereby fixing the anchor 6 to the distal end of the base 1. It is not difficult to understand that by driving the locking and holding device 1000 to rotate, the spiral anchor (i.e., the anchor 6) can be driven to anchor and engage with the target tissue.

[0075] It should be noted that the materials for the components of the locking and holding device 1000 can be stainless steel, pure titanium, titanium alloy, etc., and 316LVM stainless steel is preferably used for ease of processing and biocompatibility. Figures 14 to 17 The delivery device 3000 shown is delivered into the patient's body. The delivery device 3000 includes the aforementioned push rod 3100, release rod 3200, anchor sheath 3300 and a proximal control handle, wherein the control handle can be used to control the movement and rotation of the push rod 3100, release rod 3200 and anchor sheath 3300. The push rod 3100, release rod 3200 and anchor sheath 3300 are all configured to have a bending adjustment function to achieve the delivery of the locking and retaining device 1000 to the target position in the patient's body through the complex human vascular system. Among them, when the locking and holding device 1000 is loaded into the conveying device 3000, the locking and holding device 1000 is in the initial state and is located at the distal end of the inner cavity of the anchor sheath tube 3300, the push rod 3100 is installed in the anchor sheath tube 3300 and the distal end of the push rod 3100 abuts the driving surface of the locking member 2, and the release rod 3200 is also installed in the anchor sheath tube 3300 and the distal end of the release rod 3200 is detachably connected to the joint 15 of the locking and holding device 1000.

[0076] The following will be combined Figure 4 、 Figure 5 、 Figures 14 to 18 The use of the locking and retaining device 1000 provided in the first embodiment of the present invention will be described by taking the application of the suture 2000 in artificial chordal implantation as an example.

[0077] In the first step, a suturing device (not shown) is delivered through the delivery sheath 3500 to fix the distal end of the inner suture 2000 to the leaflet. After completing the leaflet suturing operation at the leaflet end, the suturing device is withdrawn to leave the suture 2000. At this time, the proximal end of the suture 2000 extends from the leaflet and extends to the outside of the body through the delivery sheath 3500.

[0078] The second step is Figure 4 and Figure 16 As shown, the suture 2000 extending outside the body is introduced into the delivery device 3000. Specifically, the proximal end of the suture 2000 is passed from the distal end of the anchor sheath 3300 and through the thread holes of the base 1 and the locking member 2 (i.e., the second thread hole 141 and the first thread hole 23), and then further passed out from the proximal end of the anchor sheath 3300 and the control handle. At this time, the suture 2000, the push rod 3100 and the release rod 3200 are carried in parallel in the anchor sheath 3300. Keep the suture 2000 moderately taut and adjust the tension according to the following steps: Figure 16 The illustrated method is to deliver the delivery device 3000 through the delivery sheath 3500 to the vicinity of ventricular tissue, such as the papillary muscle.

[0079] The third step, such as Figure 17 As shown, after the locking and holding device 1000 is delivered to the vicinity of the papillary muscle through the anchor sheath 3300, the bending direction of the anchor sheath 3300 is adjusted so that its distal opening points to the desired anchoring position, and the control handle of the conveying device 3000 is rotated, such as by rotating the driving mechanism of the control handle to spirally advance the release rod 3200 (it can also be manually driven), so that the locking and holding device 1000 is spirally advanced as a whole toward the distal end, thereby rotating the anchor 6 and embedding it into the papillary muscle.

[0080] The fourth step is as follows Figure 4 and Figure 5 As shown, after adjusting the tension of the suture 2000 in vitro, the control handle of the delivery device 3000 is pushed, such as pushing the actuating mechanism of the control handle to axially drive the push rod 3100 (it can also be manually driven) to actuate the locking member 2 to rotate around the connecting axis 5 to a locked state, thereby compressing the suture 2000 to complete the locking thread, thereby completing the anchoring of the suture 2000 on the papillary muscle.

[0081] Step 5: Figure 18 As shown, after the suture is locked, the push rod 3100 and the release rod 3200 are detached from the locking and holding device 1000 and the delivery device 3000 is withdrawn. Then, the suture cutting device is delivered through the delivery sheath 3500 and enters the body along the path of the suture 2000 to cut the suture 2000 near the locking and holding device 1000. The remaining suture 2000, the suture cutting device and the delivery sheath 3500 are withdrawn, and the locking and holding device 1000 remains in the patient's body, thereby completing the anchoring operation and completing the implantation of the artificial tendon.

[0082] Please combine Figure 19 and Figure 20 The locking and holding device 1000 provided in the second embodiment of the present invention has a structure basically the same as that of the locking and holding device 1000 in the first embodiment, except that: in the second embodiment of the present invention, the base 1 includes a base 16 and a shell 17 with two ends passing through, the base 16 is fixedly installed in the shell 17, the locking member 2 is rotatably connected to the shell 17, the retaining member 3 is movably arranged on the base 16, and the elastic member 4 is compressed between the retaining member 3 and the base 16.

[0083] For details, please combine Figure 21 and Figure 22 In the second embodiment of the present invention, the base 16 includes a base body 161 and a second end plate 162 and a third end plate 163 located at opposite ends of the base body 161. The second end plate 162 is a circular end plate connected to the end of the base body 161 closer to the elastic member 4, and the third end plate 163 is a semicircular end plate connected to the end of the base body 161 farther from the elastic member 4. It should be noted that the base body 161 is provided with the guide sliding surface 111 of the first embodiment, and the second end plate 162 is provided with the guide groove 121, positioning groove 123, and joint 15 of the first embodiment, which will not be described in detail.

[0084] Please combine Figure 19 and Figure 23 In the second embodiment of the present invention, housing 17 is cylindrical. When base 16 is fixedly installed in housing 17, second end plate 162 covers the opening at one end of housing 17 close to elastic member 4, and third end plate 163 covers the opening at one end of housing 17 away from elastic member 4, leaving an entrance for suture 2000 to pass through. Both second end plate 162 and third end plate 163 can be fixed to housing 17 by welding, snap-fit ​​connection, or other means, preferably welding.

[0085] Preferably, Figure 22 and Figure 23 As shown, in the second embodiment of the present invention, a first positioning structure 166 is provided on the outer peripheral wall of the third end plate 163, and a second positioning structure 172 is provided on the opening edge of the housing 17 corresponding to the first positioning structure 166. The first positioning structure 166 and the second positioning structure 172 cooperate to facilitate the rapid sealing of the third end plate 163 to the opening at the end of the housing 17 away from the elastic member 4, thereby improving the convenience and stability of the installation of the base 16 within the housing 17. The first positioning structure 166 and the second positioning structure 172 can be, but are not limited to, a projection and a groove, and this is not limited to this.

[0086] like Figure 19 and Figure 23As shown, in the second embodiment of the present invention, the housing 17 is provided with a pair of third through holes 173, and the connecting shaft 5 is installed in the corresponding third through holes 173 and the second through hole 22, so that the locking member 2 is rotatably connected to the housing 17 around the connecting shaft 5. Figure 19 and Figure 23 As shown, in the second embodiment of the present invention, the housing 17 is provided with an axially extending escape groove 171 to allow at least a portion of the locking member 2 (specifically, at least a portion of the free end) to extend out of or enter the housing 17. The escape groove 171 may extend partially from the edge of the opening at one end of the housing 17 that is covered by the third end plate 163 toward the other end opening, or may extend partially from a position adjacent to the edge of the opening at one end of the housing 17 that is covered by the third end plate 163 toward the other end opening. Preferably, the escape groove 171 extends from the edge of the opening to reduce the difficulty of manufacturing the escape groove 171.

[0087] The locking and holding device 1000 provided in the second embodiment of the present invention is different from the locking and holding device 1000 in the first embodiment in that the actuation method of the locking member 2 is different. Figure 21 、 Figures 24 to 26 In the second embodiment of the present invention, the locking member 2 is provided with a first traction hole 24, which is arranged at a position adjacent to the first wire hole 23 on the locking member 2 for the actuator ( Figure 25 and Figure 26 The base 1 (specifically, the base body 161) is provided with a radially extending second traction hole 164 near the locking member 2, and the proximal end of the base 1 (specifically, the second end plate 162) is provided with a third traction hole 165. The distal end of the actuator (i.e., the traction rope 3400) is removably connected to the first traction hole 24. The proximal end of the actuator passes through the second traction hole 164 and the third traction hole 165, then passes through the locking and holding device 1000 until it extends outside the body. Figure 25 and Figure 26As shown, in the second embodiment, by pulling the traction rope 3400 toward the proximal end, the traction rope 3400 can drive the locking member 2 to rotate around the connecting shaft 5 in a direction away from the self-locking inclined surface 31, thereby pressing the suture 2000 to achieve thread locking. It can be understood that in order to avoid the risk of the suture 2000 and the traction rope 3400 being entangled in the process of locking the suture 2000, the first traction hole 24 is provided on the side of the first wire hole 23 away from the free end of the locking member 2. In this way, the wire pressing structure of the locking member 2 and the first traction hole 24 are located on opposite sides of the first wire hole 23, which can prevent the suture 2000 from being entangled with the traction rope 3400. Furthermore, in order to ensure that the locking member 2 can effectively rotate under the drive of the traction rope 3400, the first traction hole 24 is located between the first wire hole 23 and the second through hole 22 of the locking member 2, and is spaced a certain distance from the second through hole 22. Figures 24 to 26 In the example, there are two first traction holes 24, which are arranged side by side along the extension direction parallel to the second through hole 22. The axial center of the first traction hole 24 is parallel to the axial center of the first wire hole 23 and perpendicular to the axial center of the second through hole 22. In this embodiment, the traction rope 3400 can be looped around and passed through the two first traction holes 24 so that its distal end can be detachably connected to the locking member 2. When the proximal end of the traction rope 3400 is pulled to drive the locking member 2 to rotate to the locked state and complete the locking line, one of the proximal ends of the traction rope 3400 is pulled to withdraw the traction rope 3400 from the patient's body.

[0088] It is understood that the locking and retaining device 1000 of the first embodiment can also be configured to have corresponding traction holes, so that the locking member 2 can be actuated to rotate by pulling the traction rope 3400. This will not be described in detail here. Similarly, the various components of the locking and retaining device 1000 of the second embodiment can also have the features of the corresponding components of the first embodiment. This will not be described in detail here either.

[0089] Please combine Figures 22 to 26 In the second embodiment of the present invention, one end of the suture 2000 passes through the housing 17 from the entrance formed by the opening at the end of the third end plate 163 covering the housing 17 away from the elastic member 4, and then passes through the first thread hole 23 of the locking member 2 to pass through the entire locking and retaining device 1000. The suture 2000 is located between the locking member 2 and the base 1. Figure 26As shown, when the proximal end of the traction rope 3400 is pulled to drive the locking member 2 to rotate to the locked state and complete the thread locking, the suture 2000 is compressed between the locking member 2 and the base 16. The side of the base body 161 facing the locking member 2 constitutes a bearing surface, and the free end of the locking member 2 has a thread pressing surface. The suture 2000 is compressed and deformed between the bearing surface and the thread pressing surface. Similarly, in order to ensure that the suture 2000 is compressed, preferably, the compression deformation amount L of the suture 2000 satisfies the relationship: 1 / 2*D<L<3 / 4*D, where D is the diameter of the suture 2000.

[0090] It should be noted that the locking and holding device 1000 provided in the second embodiment of the present invention is different from the locking and holding device 1000 in the first embodiment in that no anchoring member 6 is provided at the distal end of the locking and holding device 1000 .

[0091] It should also be noted that the locking and holding device 1000 provided in the second embodiment of the present invention can also be delivered into the patient's body through the aforementioned delivery device 3000. The locking and holding device 1000 in the initial state is placed at the distal end of the inner cavity of the anchor sheath 3300, the traction rope 3400 is passed through the anchor sheath 3300 and the distal end of the traction rope 3400 is detachably connected to the locking member 2, and the release rod 3200 is also passed through the anchor sheath 3300 and the distal end of the release rod 3200 is detachably connected to the joint 15 of the locking and holding device 1000.

[0092] The following will be combined Figures 25 to 29 The use of the locking and retaining device 1000 provided in the second embodiment of the present invention will be described by taking the application of the suture 2000 in the edge-to-edge repair of the mitral valve as an example.

[0093] The first step, such as Figure 27 As shown, a suturing device (not shown) is delivered through a delivery sheath 3500 to implant two sets of sutures 2000 in the anterior and posterior leaflets of the mitral valve, respectively. After completing the leaflet suturing operation at the leaflet ends, the suturing device is withdrawn to leave the sutures 2000. At this time, the proximal end of each set of sutures 2000 is extended from the leaflet and extended to the outside of the body through the delivery sheath 3500.

[0094] The second step is Figure 25 and Figure 28As shown, the suture 2000 extending outside the body is introduced into the delivery device 3000. Specifically, the proximal end of the suture 2000 is passed through the distal end of the anchor sheath 3300, then passes through the entrance formed between the third end plate 163 and the housing 17 and passes through the first thread hole 23 of the locking member 2. The suture 2000 is further passed through the proximal end of the anchor sheath 3300 and the control handle. At this time, the suture 2000, the release rod 3200 and the traction rope 3400 are carried in parallel in the anchor sheath 3300, and the traction rope 3400 is engaged with the first traction hole 24 of the locking member 2. The proximal end of the traction rope 3400 passes through the second traction hole 164 and the third traction hole 165 and then passes through the locking and holding device 1000. The distal end of the release rod 3200 is connected to the joint 15 of the base 1. Keep the suture 2000 moderately tensioned, and according to the following Figure 28 In the manner shown, the delivery device 3000 is delivered to the coaptation edge of the mitral valve through the delivery sheath 3500 , with its distal opening pointing toward the mitral valve, and the locking and holding device 1000 is located at the distal end of the inner cavity of the anchor sheath 3300 .

[0095] The third step, such as Figure 26 As shown, after adjusting the tension of the suture 2000 in vitro, the traction rope 3400 is pulled toward the proximal end by controlling the actuating mechanism of the handle or manually to actuate the locking member 2 to rotate around the connecting axis 5 to a locked state, thereby tightening the suture 2000 to complete the thread locking.

[0096] The fourth step is as follows Figure 28 As shown, after the locking is completed, the release rod 3200 and the traction rope 3400 are detached from the locking and holding device 1000 and the delivery device 3000 is withdrawn. Then, the cutting device is delivered through the delivery sheath 3500 and enters the body along the path of the suture 2000 to cut the suture 2000 near the locking and holding device 1000. The remaining cut suture 2000, the cutting device and the delivery sheath 3500 are withdrawn, and the locking and holding device 1000 remains in the patient's body, thereby completing the edge-to-edge repair of the mitral valve. Figure 29 shown.

[0097] It is understandable that, in the embodiment of the present invention, the suture 2000 may be one suture or multiple sutures, and the locking and retaining device 1000 may also be used to lock the suture 2000 in other surgeries, without limitation thereto.

[0098] The above is an implementation of the embodiment of the present invention. It should be noted that, for those skilled in the art, without departing from the principles of the embodiment of the present invention, several improvements and modifications can be made, and these improvements and modifications are also considered to be within the scope of protection of the present invention. The above is an implementation of the embodiment of the present invention. It should be noted that, for those skilled in the art, without departing from the principles of the embodiment of the present invention, several improvements and modifications can be made, and these improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. A locking and holding device, characterized in that: include: matrix; a locking member, the locking member being rotatably connected to the base, the locking member having a self-locking section; a retaining member, the retaining member being movably disposed on the base, the retaining member having a self-locking inclined surface cooperating with the self-locking section; and an elastic member, the elastic member being located between the retaining member and the base; The locking member is actuated to rotate relative to the base in a direction away from the self-locking inclined surface to a locked state, and the first position of the self-locking section is disengaged from the abutment of the self-locking inclined surface; under the action of the elastic member, the retaining member moves on the base until the self-locking inclined surface abuts and remains in the second position of the self-locking section; wherein the curvature radius of the first position is greater than the curvature radius of the second position.

2. The locking and holding device according to claim 1, wherein: The base has a guide sliding surface, and the retaining member is slidably arranged on the guide sliding surface, wherein the friction coefficient of the self-locking inclined surface is μ1, the friction coefficient of the guide sliding surface is μ2, and the angle between the self-locking inclined surface and the guide sliding surface is θ; when the self-locking inclined surface abuts at the second position, the force exerted by the elastic member on the retaining member is F1, the force exerted by the locking member on the retaining member is F2, and the angle θ satisfies the relationship: tanθ≤μ1+μ2+F1 / (F2*cosθ).

3. The locking and holding device according to claim 2, wherein: An included angle θ between the self-locking inclined surface and the guide sliding surface is less than or equal to 45 degrees.

4. The locking and holding device according to claim 1, wherein: The locking and holding device further includes a connecting shaft, and the locking member is rotatably connected to the base body around the connecting shaft.

5. The locking and holding device according to claim 1, wherein: The self-locking section is an arc-shaped outer surface with a curvature radius gradually decreasing from the first position to the second position.

6. The locking and holding device according to claim 1, wherein: The retaining member includes a wedge block and a guide column connected to one end of the wedge block, the self-locking inclined surface is arranged on the wedge block and faces away from the guide column, and the elastic member is sleeved on the guide column and axially compressed between the wedge block and the base.

7. The locking and holding device according to claim 6, wherein: The elastic member includes a spring sheet, which includes an open end and a curved end connected to the open end. The open end abuts against the base, the curved end abuts against the wedge block, and the curved end is provided with a through hole for the guide column to pass through.

8. The locking and holding device according to claim 6, wherein: The base is provided with an axially extending guide groove, and one end of the guide post away from the wedge block is at least partially accommodated in the guide groove and can move axially relative to the guide groove.

9. The locking and holding device according to claim 1, wherein: A guide hole is provided at the proximal end of the base, and the locking member is provided with a driving surface. The distal end of an actuator passes through the guide hole and engages with the driving surface to actuate the locking member.

10. The locking and holding device according to claim 1, wherein: The locking member is provided with a first traction hole, the base is provided with a radially extending second traction hole at a position adjacent to the locking member, the proximal end of the base is provided with a third traction hole, the distal end of an actuator is removably engaged with the first traction hole, and the proximal end of the actuator passes through the second traction hole and the third traction hole and then out of the locking and retaining device.

11. The locking and holding device according to claim 1, wherein: The locking member is provided with a first thread-passing hole for passing a suture. Driven by the locking member, the suture moves toward the base until it is pressed against the base by the locking member.

12. The locking and holding device according to claim 11, wherein: An extension portion is radially extended from one end of the base away from the elastic member, and the extension portion and the locking member are located on the same side of the base; the extension portion is provided with a second thread hole, and the suture axially passes through the second thread hole and the first thread hole and then passes through the locking and retaining device.

13. The locking and holding device according to claim 11, wherein: The base is provided with a protrusion at one end away from the elastic member. When the locking member presses the suture, the protrusion is at least partially accommodated in the first thread hole, and the protrusion squeezes the suture passing through the first thread hole.

14. The locking and holding device according to claim 1, wherein: The base includes a base and a shell with two ends extending therethrough, and the base is fixedly installed in the shell; The locking member is rotatably connected to the shell, the retaining member is movably arranged on the base, and the elastic member is compressed between the retaining member and the base; the shell is provided with an axially extending avoidance groove to allow at least part of the locking member to extend out of or enter the shell.

15. The locking and holding device according to claim 1, wherein: A coupling portion is provided at the proximal end of the base body, and the coupling portion is used for detachably connecting a driver, and the driver is used for driving the locking and holding device to move.

16. The locking and holding device according to claim 1, wherein: The locking and holding device further includes an anchor connected to the distal end of the base, the anchor being adapted to engage a target tissue.

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