Application of isoliquiritigenin as polymyxin synergist

Through the combination of isoglycidine and polymyxin, the problem of polymyxin-resistant Salmonella infection was solved, significantly improving the therapeutic effect and avoiding the emergence of drug resistance.

CN119632962AInactive Publication Date: 2025-03-18SOUTH CHINA AGRICULTURAL UNIVERSITY
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Patent Information

Application Number
CN202411634740.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-15
Publication Date
2025-03-18
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The prior art is difficult to effectively solve the infection of polymyxin-resistant Salmonella, especially the resistance of Enterobacteriaceae bacteria to polymyxin, resulting in a decrease in the therapeutic effect.

Method used

The combination of isoglycyrrhizin and polymyxin, which isoglycyrrhizin as a polymyxin synergist, significantly enhancing the sensitivity of Salmonella to polymyxin through combined use.

Benefits of technology

It significantly reduces the minimum inhibitory concentration of polymyxin on salmonella, improves the killing effect of polymyxin-resistant salmonella, and avoids the development of drug resistance of polymyxin-resistant drugs.

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Abstract

The invention belongs to the technical field of biological medicine, and discloses application of isoliquiritigenin as a polymyxin synergist. Through combination of isoliquiritigenin and polymyxin, it is found that isoliquiritigenin and polymyxin have a good effect on in-vivo and in-vitro salmonella inhibition. The isoliquiritigenin is safe in component, can achieve a good synergistic effect with the polymyxin, can significantly reduce the dosage of the polymyxin, is not easy to induce the generation of bacterial drug resistance, and has the characteristics of low price and good curative effect.
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