Use of composition for enhancing nocturnal repair-related functions of skin

Abstract

The present invention relates to the use of a topical composition for enhancing nighttime repair-related functions of the skin. This is achieved by a vitamin B3 compound or a derivative thereof; or by a combination of a vitamin B3 compound or a derivative thereof and an alkyl-substituted dihydroxybenzene, wherein the alkyl group comprises 2 to 10 carbon atoms.

Description

Field of the Invention

[0001] The present invention relates to the use of topical compositions for enhancing the nighttime repair-related functions of the skin. Background Art

[0002] Exposure of human skin to UV radiation can produce a range of adverse effects on the skin, both acutely and chronically. Additionally, current lifestyles, especially among younger generations, that often involve delayed and insufficient sleep, overexposure to blue light, and inherent stress / anxiety are causes for concern. These factors impact multiple skin functions, ultimately affecting skin appearance, including pigmentation, aging, and radiance. Skin processes are naturally regulated to provide more protection during the day, while at night, the skin focuses on repair. Because skin function changes from day to night, it would be advantageous if nighttime cosmetics could help skin repair, while daytime products could help skin maximize protection.

[0003] The present inventors found that vitamin B3 compounds or derivatives thereof provide this benefit when looking for solutions to the problem of providing enhanced levels of nighttime repair-related functions to the skin. They also found a synergistic interaction to provide a combination of active substances for this benefit. They found that the combination of vitamin B3 compounds or derivatives thereof and alkyl-substituted dihydroxybenzenes (wherein the alkyl group contains 2 to 10 carbon atoms) provides this synergistic effect. They further found that when the composition comprising the vitamin B3 compound is applied to the skin in the evening (evening) / night (night), for example, from about 5pm to 12am at the end of the day, the nighttime repair function of the skin is enhanced. In addition, they found that when the composition comprising the vitamin B3 compound or derivatives thereof and the alkyl (C2-C10)-substituted dihydroxybenzenes is applied to the skin in the evening / night, for example, from about 5pm to 12am at the end of the day, the nighttime repair function of the skin is enhanced.

[0004] It is therefore an object of the present invention to deliver enhanced nighttime repair related functions to the skin.

[0005] Another object of the present invention is to deliver this benefit through multiple actives that interact synergistically, thereby ensuring that low concentrations of actives are used, which provides the consumer with a low cost product and a product with minimal side effects. SUMMARY OF THE INVENTION

[0007] A first aspect of the present invention relates to the use of a composition comprising a vitamin B3 compound or a derivative thereof and an alkyl-substituted dihydroxybenzene for enhancing the nighttime repair function of the skin, wherein the alkyl group comprises 2 to 10 carbon atoms, wherein the composition is applied to the skin in the evening or at night.

[0008] A preferred aspect of the present invention relates to the use of the composition of the first aspect, said composition further comprising a cosmetically acceptable carrier, said composition preferably being in the form of a lotion, cream, gel, serum or essence.

[0009] Another aspect of the present invention relates to a method for enhancing nighttime repair-related functions of the skin, comprising the step of applying the composition of the present invention to a desired skin surface, wherein the composition is applied to the skin in the evening or at night.

[0010] Yet another aspect of the present invention relates to use of a composition comprising a vitamin B3 compound or a derivative thereof for enhancing the nighttime repair function of the skin, wherein the composition is applied to the skin in the evening or at night. DETAILED DESCRIPTION OF THE INVENTION

[0012] By reading the following detailed description and the appended claims, these and other aspects, features and advantages will become apparent to those of ordinary skill in the art. For the avoidance of doubt, any feature of one aspect of the present invention may be used in any other aspect of the present invention. The word "comprising" is intended to mean "including", but not necessarily "consisting of" or "consisting of". In other words, the steps or options listed do not have to be exhaustive. It should be noted that the examples given in the following description are intended to illustrate the present invention, but are not intended to limit the present invention to those embodiments themselves. Similarly, unless otherwise indicated, all percentages are weight / weight percentages. Except in the examples and comparative examples, or in the case of otherwise explicitly indicated, all numbers indicating the amount of material or reaction conditions, the physical properties of the material and / or the use in this specification and claims should be understood to be modified by the word "about". Numerical ranges expressed in the format "from x to y" should be understood to include x and y. When multiple preferred ranges are described in the format "from x to y" for a particular feature, it should be understood that all ranges combining different endpoints are also included.

[0013] The topical composition of the present invention is intended for personal care or cosmetic purposes, and may also be referred to as a personal care composition or a cosmetic composition. As used herein, "personal care composition" means a composition including compositions for topical application, i.e., the outer surface of the skin and / or hair of a person. Such compositions are usually disposable, and include any product applied to the human body to improve appearance, odor control, or general aesthetics. The composition of the present invention may be in the form of an emulsion, cream, essence, essence, or gel, preferably in the form of an essence or essence. Essences are generally considered to be high-concentration / potent disposable products containing active ingredients / skin-benefiting ingredients. On the other hand, essences are water-based compositions containing active ingredients to hydrate and protect the skin. Both forms are intended to be used to make active substances easily absorbed and deeply penetrated into the skin layer.

[0014] As used herein, "skin" is meant to include the skin on the face and body (eg, neck, chest, back, arms, underarms, hands, legs, and scalp), especially exposed portions thereof.

[0015] "Evening" or "nighttime" as used in the context of the present invention preferably means that the composition is applied to the skin at the end of the day, preferably from about 5 pm to about 12 am, more preferably from about 6 pm to about 11:30 pm, even more preferably from about 7 pm to about 11:00 pm, even more preferably from about 8 pm to about 10:30 pm, still more preferably from about 9 pm to about 10:00 pm.

[0016] In the context of the time of applying the composition at the end of the day as described above, the term "about" is intended to include changes of about 15 to 30 minutes from the time range specified therein. For example, about 5 pm is intended to include 15 or 30 minutes earlier than 5 pm, i.e., 4:45 pm or 4:30 pm. Similarly, about 12 am is intended to include 12:15 am or 12:30 am.

[0017] The present invention relates to the use of a composition comprising a vitamin B3 compound or a derivative thereof for enhancing the nighttime repair function of the skin, wherein the composition is applied to the skin in the evening or at night.

[0018] The present invention also relates to the use of a composition comprising a vitamin B3 compound or a derivative thereof and an alkyl-substituted dihydroxybenzene for enhancing the nighttime repair function of the skin, wherein the alkyl group comprises 2 to 10 carbon atoms, wherein the composition is applied to the skin in the evening or at night.

[0019] The vitamin B3 compound or its derivative is preferably selected from one or more of nicotinic acid, nicotinamide, picolinamide, isonicotinamide, methylnicotinamide, cyclopropylnicotinamide and cyclopentylnicotinamide. More preferably, it is selected from one or more of nicotinamide, picolinamide and isonicotinamide. Most preferably, nicotinamide. The composition preferably comprises 0.1-5%, more preferably 0.1-3%, even more preferably 0.1-1% of the vitamin B3 compound or its derivative by weight of the total composition.

[0020] Alkyl-substituted dihydroxybenzenes have the general chemical structure (I) given below:

[0021]

[0022] Where R1 is C2-C 10 alkyl; and each of R2 to R6 is an OH group or H; and

[0023] wherein at least two of R2 to R6 are OH.

[0024] The more preferred alkyl-substituted dihydroxybenzenes for use in the present invention have the structure

[0025]

[0026] Where R1 is C2-C 10 Alkyl; R2 and R3 are OH.

[0027] Preferably R1 is an alkyl group containing 2 to 6 carbon atoms, most preferably containing 2, 4 or 6 carbon atoms. The two hydroxyl groups are usually located at the 1st and 3rd positions. Such compounds are generally referred to as substituted resorcinols. Therefore, the most preferred compounds are ethylresorcinol, butylresorcinol or hexylresorcinol. Most preferably, 4-substituted resorcinols. Therefore, the resorcinol that can be used is 4-ethylresorcinol (4-ER), 4-butylresorcinol (4-BR) or 4-hexylresorcinol (4-HR). The most preferred compound for the present invention is 4-hexylresorcinol. This compound has the following structure:

[0028]

[0029] This compound is also known by its synonyms 4-hexylbenzene-1,3-diol and 4-hexyl-1,3-benzenediol.

[0030] Hexylresorcinol is known to exhibit antiseptic and local anesthetic properties. It has been used for topical application for minor skin infections, oral solutions for pain relief, and as a first aid disinfectant. It is also used as a skin lightener in skin care. The compound is also known to have antioxidant properties and has therefore been used in skin care compositions to provide an even-toned complexion or in anti-aging products.

[0031] The alkyl-substituted dihydroxybenzene compound is preferably contained in an amount of 0.01 to 1 wt %, more preferably 0.05 to 0.5 wt %, and still more preferably 0.1 to 0.4 wt % of the composition.

[0032] Without wishing to be bound by theory, the inventors believe that the technical effect, namely the enhancement of the nighttime repair function of the skin, occurs due to the following reasons.

[0033] Vitamin B3 compounds or their derivatives, such as nicotinamide, are the main precursors of nicotinamide adenine dinucleotide (NAD+), which is an essential coenzyme for DNA repair, glycolysis, autophagy, oxidative phosphorylation, cellular energy, etc. Nicotinamide also increases the ratio of NAD+ / NADH in skin cells, and also activates SIRT1 and NAD+-dependent deacetylases, which play an important role in the autophagic flow and the circadian transcription of several core clock genes. NADH effectively acts as an energy storage component and provides high-energy electrons to the mitochondrial electron transport chain when needed. Nicotinamide is also known to induce the antioxidant system in skin cells by activating Nrf2 signaling, which plays an important role in regulating oxidative stress in skin cells.

[0034] It is known that the claimed alkyl-substituted dihydroxybenzene compounds, such as hexylresorcinol (HR), can be used as skin-brightening agents. It can also act as an antioxidant that helps to achieve a more even skin tone. As an antioxidant protectant, hexylresorcinol can neutralize free radicals generated in skin cells by ultraviolet light, blue light, pollution, etc. In addition, HR can activate a variety of other skin functions, including Nrf2 activation, antioxidant response element (ARE)-reporter gene activity, and expression of ARE-dependent genes NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1).

[0035] Based on these insights, the inventors hypothesize that the effects of the combination of claimed ingredients can be attributed to the activation of NRF2 signaling, increasing the expression of NADPH dehydrogenase and other antioxidant enzymes by hexylresorcinol, and enhancing the NAD+ / NADH ratio and activating SIRT1 and NAD+-dependent deacetylases by nicotinamide, leading to the observed benefits.

[0036] The composition of the present invention can be delivered in the form of an emulsion, cream, essence, serum or gel, wherein the essence, serum or gel form is more preferred, and the essence and serum form are the most preferred. To achieve this, the composition may include a cosmetically acceptable carrier. The cosmetically acceptable carrier is preferably selected from water (which can be thickened using a polymer), or an emulsion that can be a water-in-oil or oil-in-water emulsion (emulsion). The product in the form of an emulsion or cream is typically an emulsion.

[0037] All of these product forms typically have a high water content, which may be from 55 to 99%, preferably from 70 to 95%, more preferably from 85 to 95% by weight of the composition.

[0038] Products in gel form contain predominantly water at 65-90% by weight of the composition, products in serum form contain predominantly water at 60-90% by weight of the composition, and products in serum form contain predominantly water at 85-95% by weight of the composition.

[0039] The cosmetically acceptable carrier in the composition of the present invention preferably comprises an emulsifier, a thickener, a humectant, an emollient oil or a mixture thereof.

[0040] The thickener is preferably selected from one or more of acrylate / alkyl acrylate crosspolymers, carbomers, ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymers and ammonium acryloyldimethyltaurate / VP copolymers. The most preferred thickener is acrylate / alkyl acrylate crosspolymers. These products are sold under the trade names Pemulene TR-1, Pemulene TR-2, Ultrez 20, Ultrez 21. Other polymers that may be included are crosslinked acrylates (e.g., Carbopol 982), hydrophobically modified acrylates (e.g., carbopol 1382), carbomers and ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymers, ammonium acryloyldimethyltaurate / VP copolymers, cellulose derivatives and natural gums. Useful cellulose derivatives include sodium carboxymethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, ethyl cellulose and hydroxymethyl cellulose. Natural gums suitable for use in the present invention include guar gum, xanthan gum, sclerotium, carrageenan, pectin and combinations of these gums. The most preferred thickener is selected from one or more of acrylates / alkyl acrylate crosspolymers, carbomers, ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymers and ammonium acryloyldimethyltaurate / VP copolymers. The concentration of the thickener in the composition can be 0.0001-5% by weight, typically 0.001-1%, and optimally 0.01-0.5%.

[0041] The composition of the present invention may contain a humectant, which is typically a polyol. Preferably, the humectant is at least one of propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, isopentylene glycol, 1,3 propanediol, pentylene glycol, hexylene glycol, 1,2,6-hexanetriol, glycerol, ethoxylated glycerol, and propoxylated glycerol. Preferred humectants are selected from one or more of glycerol, 1,3-butylene glycol, propylene glycol, 1,3 propanediol, pentylene glycol, hexylene glycol, and sorbitol. Glycerol is the most preferred humectant. Preferably, the amount of the humectant is 1-10% by weight of the composition, more preferably 2-8%.

[0042] The composition may optionally include a skin whitening compound. Exemplary substances are placental extract, lactic acid, arbutin, kojic acid, ferulic acid, hydroquinone, hydroxystearic acid (HSA) (preferably 12-HAS), pyridoxine hydrochloride, alpha hydroxy acid (AHA), beta hydroxy acid (BHA), polyhydroxy acid (PHA) or natural skin whitening extracts (such as honey or lemon extract) and combinations thereof. More preferably, such skin whitening compounds are selected from one or more of hydroxystearic acid, pyridoxine hydrochloride, AHA, BHA, PHA or natural skin lightening extracts (such as honey or lemon extract). The amount of these skin whitening compounds can be 0.01-10%, preferably 0.1-2%, by weight of the composition.

[0043] The preferred form of the solid form of the composition is a cream, even more preferably a cream with a vanishing cream base. The vanishing cream base is a base comprising 3 to 25 wt% fatty acids. Optionally, the composition may comprise 0.1 to 10 wt% soap. When included, the fatty acid is preferably a C10-C22 fatty acid, more preferably a C16-C18 fatty acid. Most preferably, the fatty acid is stearic acid or palmitic acid or a mixture thereof, and the soap is preferably the potassium salt of the fatty acid mixture. The fatty acid is typically hystric acid, which is essentially (typically about 90 to 95%) a mixture of 45% stearic acid and 55% palmitic acid.

[0044] Preferably, the composition comprises an emollient. Examples of emollients that can be used in a leave-on composition include stearyl alcohol, glyceryl monoricinoleate, mink oil, isopropyl isostearate, isobutyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecane-2-ol, isohexadecanol, eicosanol, behenyl alcohol, cetyl palmitate, silicone oils (e.g., dimethicone), di-n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl stearate Esters, butyl stearate, polyethylene glycol, triethylene glycol, lanolin, cocoa butter, corn oil, cottonseed oil, olive oil, palm kernel oil, rapeseed oil, safflower seed oil, evening primrose oil, soybean oil, sunflower seed oil, avocado oil, sesame seed oil, coconut oil, peanut oil, castor oil, acetylated lanolin alcohol, petrolatum, mineral oil, butyl myristate, isopropyl linoleate, lauryl lactate, myristyl lactate, decyl oleate, myristyl myristate, and mixtures thereof.

[0045] Preferably, the composition comprises a solvent. Examples of solvents that can be used in the composition include ethanol, isopropanol, acetone, ethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, and mixtures thereof.

[0046] Preferably, the composition comprises a powder. Examples of powders that can be used in the composition include chalk, talc, Fuller's earth, kaolin, starch, gum, colloidal silica sodium polyacrylate, tetraalkyl and / or trialkyl aryl ammonium montmorillonite, chemically modified magnesium aluminum silicate, organically modified montmorillonite clay, hydrated aluminum silicate, fumed silica, carboxyvinyl polymers, sodium carboxymethylcellulose, ethylene glycol monostearate, and mixtures thereof.

[0047] Preferably, the composition contains a preservative to prevent the growth of potentially harmful microorganisms. Examples of ingredients that can be used as preservatives in the composition include alkyl esters of parahydroxybenzoic acid, hydantoin derivatives, propionates, and various quaternary ammonium compounds. More preferably, ingredients that can be used as preservatives in the composition are sodium benzoate, iodopropynyl butylcarbamate, methylisothiazolinone, iodopropynyl butylcarbamate, phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, ethylhexylglycerin, benzyl alcohol, alkane diols, and mixtures thereof. Alkanediols suitable for use as preservatives are C6-C8 substituted with hydroxyl groups at the ortho position. 12 Alkanes. Illustrative examples include 1,2-octanediol (caprylyl glycol), 2,3-octanediol, 1,2-nonanediol, 1,2-decanediol, 1,2-hexanediol, 3,4-octanediol, mixtures thereof, and the like, of which caprylyl glycol is generally the most preferred. When present in the composition, the preservative is preferably added in an amount of 0.001 to 5 wt %, more preferably 0.01 to 3 wt %, most preferably 0.02 to 2 wt %, and even more preferably 0.25 to 1.5%.

[0048] Preferably, the composition comprises a range of other optional ingredients including antioxidants, binders, buffers, colorants, astringents, fragrances, sunscreens, conditioners, exfoliants, pH adjusters, skin sensates, skin soothing agents and skin healing agents.

[0049] Another aspect of the present invention relates to a method for enhancing the nighttime repair function of the skin, the method comprising the step of applying the composition of the present invention to the desired skin surface. The composition is preferably applied to the skin in the evening or at night. In other words, the composition is applied to the skin from about 5 pm to about 12 am at the end of the day.

[0050] Another aspect of the present invention relates to the use of a composition comprising a vitamin B3 compound or a derivative thereof for enhancing the nighttime repair function of the skin, wherein the composition is applied to the skin in the evening or at night.

[0051] The invention will now be illustrated with the aid of the following non-limiting examples. Example

[0052] The study was conducted on two consecutive days (day 1 and day 2) to evaluate the gene expression of skin repair markers associated with nighttime. The following genes were studied: skin circadian rhythm genes (BMAL1; NCBI database accession number NM_001297719), autophagy (LC3B; NCBI database accession number NG_029030); DNA repair (XPA; NCBI database accession number NM_000380) and cell proliferation (CCND1 / Cyclin D1; NCBI database accession number NM_053056) were detected in human epidermal primary keratinocytes (NHEK; Cascade Biologics, USA) using RT-PCR. The results obtained are shown in Table 1 below.

[0053] Table 1

[0054]

[0055] The data in Table 1 above show that the expression levels of BMAL1, LC3B, XPA and Cyclin D1 genes are upregulated at night compared to the levels during the day. Importantly, these upregulated expression levels of these genes occur in the absence of any active substance, i.e., when the cells are not treated with any active substance.

[0056] Vitamin B3 compounds or their derivatives enhance the effect of the skin's nighttime repair function:

[0057] Here, NHEK cells were treated with nicotinamide (10 mM) for 12 hours ± 30 minutes at about 7.30 pm ± 30 minutes in the evening; and gene expression studies were performed as described above. The results obtained are shown in Table 2 below:

[0058] Table 2

[0059] Fold change Control (untreated) 1 LC3B 1.71 XPA 2.19 Cyclin D1 2.22

[0060] Effects of vitamin B3 compounds or their derivatives on enhancing / restoring the circadian rhythm and night-time repair function of the skin under stress conditions:

[0061] Here, NHEK cells were exposed to cortisol (a known stress inducer) for 12 hours ± 30 minutes, and then treated with nicotinamide for 12 hours ± 30 minutes at about 7.30 pm ± 30 minutes in the evening, as shown in Table 3 below; and gene expression studies were performed as described above. The results obtained are shown in Table 3 below:

[0062] Table 3

[0063]

[0064] Benefits of the composition of the present invention under blue light stress-free conditions

[0065] In order to determine the nighttime repair benefits of vitamin B3 compounds or their derivatives and alkyl-substituted dihydroxybenzenes (wherein the alkyl group comprises 2 to 10 carbon atoms, such as nicotinamide + 4-HR), human epidermal primary keratinocytes were treated with 1 μM 4-HR + 10 mM nicotinamide for 12 ± 30 min in the evening (8 pm + / - 30 min), and the gene expression study of the nighttime repair-related marker (LC3B) of autophagy was performed in NHEK cells; DNA repair (XPA) and cell proliferation (CCND1 / cyclin D1) were detected using RT PCR. The data are summarized in Table-4 below.

[0066] Table-4

[0067] sample Gene expression fold change Comparison 1.0 XPA 2.4 LC3B 2.2 CCND1 (Cyclin D1) 2.3

[0068] The gene expression level obtained for the control (no treatment) was taken as 1 (no change); and the fold changes shown in Table 4 above were calculated over the expression levels obtained for the control.

[0069] The data in Table-4 above indicate that 4-HR+nicotinamide up-regulated the expression of genes related to nighttime repair by more than 2-fold.

[0070] Benefits of the composition of the present invention under blue light stress

[0071] As shown in Table 5 below, under blue light exposure (445 nm, 5.7 J / cm 2 ) were used to perform similar experiments as above; and the gene expression of skin circadian rhythm genes (BMAL1) and autophagy night repair markers (LC3B) were studied in NHEK cells; DNA repair (XPA) and cell proliferation (CCND1 / cyclin D1) were detected using RT PCR. The data are summarized in Table-5 below.

[0072] Table-5

[0073] sample Gene expression fold change Comparison 1.0 BMAL1 (Blu-ray) 0.56 BMAL1 (blue light + 1μM 4-HR + 1mM nicotinamide) 1.40 XPA (Blu-ray) 0.76 XPA (blue light + 1μM 4-HR + 1mM nicotinamide) 1.65 LC3b(Blue light) 0.77 LC3b (blue light + 1μM 4-HR + 1mM nicotinamide) 1.39 Cyclin D1 (blue light) 0.58 Cyclin D1 (blue light + 1μM 4-HR + 1mM nicotinamide) 1.77

[0074] The data in Table 5 above indicate that the composition of the present invention can reverse the adverse effects of blue light on nighttime repair function.

Claims

1. Use of a composition comprising a vitamin B3 compound or a derivative thereof and an alkyl-substituted dihydroxybenzene for enhancing the nighttime repair function of the skin, wherein the alkyl group comprises 2 to 10 carbon atoms, wherein the composition is applied to the skin in the evening or at night.

2. The use according to claim 1, wherein the vitamin B3 compound or its derivative is selected from one or more of nicotinic acid, nicotinamide, pyridine carboxamide, isonicotinamide, methylnicotinamide, cyclopropylnicotinamide and cyclopentylnicotinamide.

3. The use according to claim 2, wherein the vitamin B3 compound or its derivative is niacinamide.

4. Use according to any one of the preceding claims, wherein the alkyl-substituted dihydroxybenzene is selected from one or more of 4-ethylresorcinol, 4-butylresorcinol and 4-hexylresorcinol.

5. Use according to any one of the preceding claims, wherein the composition additionally comprises a cosmetically acceptable carrier.

6. Use of the composition according to claim 5, which is in the form of an emulsion, cream, gel, essence or serum.

7. Use of a composition according to claim 5 or 6, said composition comprising 55-99% water.

8. Use as claimed in any one of the preceding claims, wherein the vitamin B3 compound or derivative thereof is comprised in an amount of 0.1 to 5 wt% of the composition.

9. Use as claimed in any one of the preceding claims, wherein the alkyl-substituted dihydroxybenzene is comprised in an amount of 0.01 to 1 wt% of the composition.

10. Use of a composition according to any one of the preceding claims 5 to 9, wherein the cosmetically acceptable carrier comprises an emulsifier, a thickener, a humectant, an emollient oil or a mixture thereof.

11. The use of the composition according to claim 10, wherein the thickener is selected from one or more of acrylates / alkyl acrylate crosspolymer, carbomer, ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer and ammonium acryloyldimethyltaurate / VP copolymer.

12. Use of the composition according to claim 10 or 11, wherein the humectant is one or more polyols selected from glycerol, 1,3-butylene glycol, propylene glycol, 1,3-propanediol, pentylene glycol, hexylene glycol and sorbitol.

13. A method for enhancing the nighttime repair function of the skin, comprising the step of applying the composition of any one of the preceding claims to a desired skin surface, Wherein the composition is applied to the skin in the evening or at night.

14. Use of a composition comprising a vitamin B3 compound or a derivative thereof for enhancing the nighttime repair function of the skin, wherein the composition is applied to the skin in the evening or at night.

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