An experimental monkey pathogen detection device

Abstract

The present invention discloses a pathogenic detection device for experimental monkeys, which relates to the field of pathogenic detection. It includes an annular sleeve and a fixing plate. The fixing plate is fixed on the right side of the annular sleeve. A positioning mechanism is installed on the fixing plate. The positioning mechanism includes a support seat, a groove, a top plate, a guide rod and a second spring. The support seat is fixed on the fixing plate. A current intercepting mechanism is connected to the support seat. A groove is formed on the support seat, and a vacuum sampling tube is placed in the groove. A top plate is arranged at the rear of the support seat and contacts the rear end of the vacuum sampling tube. For this pathogenic detection device for experimental monkeys, through the functions of the controller, the storage battery and the air pump, the inflation and deflation of the fixing airbag and the annular airbag can be realized. By inflating the fixing airbag and the annular airbag, the fixing airbag and the annular airbag expand, so that the fixing effect between the annular sleeve and the arm of the experimental monkey can be realized, and the expansion of the annular airbag can act as a tourniquet for subsequent blood collection.

Description

Technical Field

[0001] The present invention relates to the technical field of pathogen detection, and specifically to a pathogen detection device for experimental monkeys. Background Art

[0002] An experimental monkey refers to a monkey that is artificially cultivated, with the microorganisms and parasites it carries being controlled, having a clear genetic background or a clear source, and being used in projects such as vaccine and drug R & D experiments and physiological experiments. It is mainly applied in the pre - clinical stage of new drug R & D;

[0003] Before conducting experiments on experimental monkeys, pathogen detection is usually required. Among them, B - virus detection is a crucial step. When detecting B - virus, venous blood samples of the experimental monkeys need to be collected. At present, during the blood sampling process of experimental monkeys, blood collection mainly relies on a blood collection needle. After the blood collection needle is inserted into the experimental monkey, it is necessary to manually hold and position the blood collection device, which is rather troublesome (especially for a large amount of blood collection). Moreover, when the experimental monkey reacts violently to blood collection, multiple medical staff are required to assist in blood collection. Therefore, in view of the above problems, an experimental monkey pathogen detection device is designed to better meet the actual use requirements. Summary of the Invention

[0004] The purpose of the present invention is to provide an experimental monkey pathogen detection device to solve the problems raised in the above - mentioned background art.

[0005] To achieve the above object, the present invention provides the following technical solution: An experimental monkey pathogen detection device, comprising an annular sleeve and a fixing plate. The fixing plate is fixed to the right side of the annular sleeve. A positioning mechanism is installed on the fixing plate. The positioning mechanism includes a support base, a groove, a top plate, a guide rod and a second spring. The support base is fixed to the fixing plate. A shut-off mechanism is connected to the support base. A groove is formed in the support base. A vacuum sampling tube is placed in the groove. A top plate is arranged at the rear side of the support base and contacts the rear end of the vacuum sampling tube. An anti-slip pad is fixed to the contact surface between the top plate and the vacuum sampling tube. On the side of the top plate close to the support base, guide rods are symmetrically fixed on the left and right. The guide rods are slidably connected to the support base. One end of the guide rod is fixed to the second spring, and the other end of the second spring is fixed in the support base. The shut-off mechanism includes a movable plate, a shut-off plate, a sliding rod, a third spring and a vertical plate. The movable plate is arranged at the front side of the support base. A shut-off plate is fixed to the movable plate. A hose is arranged between the shut-off plate and the support base. Sliding rods are symmetrically fixed on the left and right on the movable plate. The sliding rods are slidably connected to the support base. A third spring is also fixed between the sliding rods and the support base, and the elastic coefficient of the third spring is less than that of the second spring. A vertical plate is fixed to the sliding rod and is slidably connected to the support base and contacts the front end of the vacuum sampling tube. An anti-slip pad is fixed to the contact surface between the vertical plate and the vacuum sampling tube. After the vacuum sampling tube is fixed, under the action of the second spring and the third spring, the vertical plate, the movable plate and the shut-off plate move forward a certain distance, so that the shut-off plate is separated from the hose, and blood can flow normally in the hose. When the vacuum sampling tube is disassembled, under the action of the third spring, the shut-off plate presses the hose to hinder blood flow.

[0006] Preferably, a controller, a storage battery and an air pump are installed on the upper end surface of the annular sleeve, and the controller, the storage battery and the air pump are distributed in sequence from front to back on the annular sleeve. The controller is electrically connected to the storage battery and the air pump. The storage battery can supply power to the air pump, and the controller is used to control the air pump to work, which can ensure the normal operation of the device.

[0007] Preferably, the air pump is connected to a fixed airbag and an annular airbag through a conduit, and the fixed airbag and the annular airbag are communicated. Pressure sensors are installed in both the fixed airbag and the annular airbag. The annular airbag can be used to press the arm of the experimental monkey, acting as a tourniquet for subsequent blood collection operations.

[0008] Preferably, the fixed airbags are symmetrically distributed about the center line of the annular sleeve, and the fixed airbags are arc-shaped structures. Through the action of the fixed airbags, the device can be fixed to the arm of the experimental monkey to ensure the stability of the device installation.

[0009] Preferably, an auxiliary support mechanism is also fixed on the annular sleeve. The auxiliary support mechanism includes a bracket, a cross bar, a slider, an ear plate, a movable frame, a circular plate, a first spring and a positioning seat. The brackets are symmetrically fixed on the annular sleeve from left to right. A cross bar is fixed on the brackets. A slider is slidably connected to the cross bar. Through the sliding action between the slider and the cross bar, it can provide a basic guarantee for the subsequent piercing of the piercing needle, thus ensuring the normal progress of blood collection.

[0010] Preferably, an ear plate is fixed on the slider, and a movable frame is slidably connected to the ear plate. Through the sliding action between the movable frame and the ear plate, the position of the movable frame can be adjusted to ensure that the positioning seat is always in contact with the arm of the experimental monkey.

[0011] Preferably, a circular plate is fixed on the movable frame, and one end of the circular plate is fixed to one end of the first spring. The other end of the first spring is fixed to the ear plate. Through the elastic action of the first spring, it can provide a force for the positioning seat to ensure the stability of the positioning seat. Also, through the elastic action of the first spring, it can provide a basic guarantee for the automatic reset of the movable frame.

[0012] Preferably, a positioning seat is fixed on the movable frame. A clamping groove is formed on the positioning seat. A piercing needle is nested and installed in the clamping groove on the positioning seat. Through the function of the positioning seat, the auxiliary positioning of the piercing needle can be realized, and there is no need to manually hold the piercing needle for positioning, improving the convenience of using the device.

[0013] Preferably, one end of the piercing needle is connected to one end of a flexible tube, and the other end of the flexible tube is connected to a blood drainage needle. Through the above structure, a blood collection mechanism is formed to ensure the normal blood collection function.

[0014] Preferably, the intercepting plates are evenly distributed on the movable plate, and the cross section of the intercepting plate is triangular. Through the action of multiple groups of intercepting plates and the triangular cross-sectional structure of the intercepting plates, pressure concentration can be achieved, so as to ensure that a large squeezing force can be generated on the flexible tube, and then the flexible tube is deformed to block blood flow.

[0015] Compared with the prior art, the beneficial effects of the present invention are:

[0016] 1. In the process of using this experimental monkey pathogen detection device, through the functions of the controller, the storage battery and the air pump, the inflation and deflation of the fixed airbag and the annular airbag can be realized. By inflating the fixed airbag and the annular airbag, the fixed airbag and the annular airbag expand, so that the fixing effect of the annular sleeve on the arm of the experimental monkey can be realized, and the expansion of the annular airbag can act as a tourniquet for subsequent blood collection.

[0017] 2. During the use of the experimental monkey pathogen detection device, the position of the top plate can be adjusted through the action of the guide rod and the second spring, so as to adjust the distance between the top plate and the vertical plate, which is convenient for the installation of the vacuum sampling tube. After the vacuum sampling tube is installed, through the action of the second spring, the guide rod, the top plate, the third spring and the vertical plate, the vacuum sampling tube can be clamped and fixed, without manual holding and fixing, liberating the hands of the staff. Multiple experimental monkeys can be sampled for blood pressure at the same time, improving the convenience and efficiency of blood collection. After the vacuum sampling tube is clamped and fixed, at this time, the intercepting plate is separated from the hose, releasing the pressing effect on the hose, ensuring the normal progress of blood collection. After blood collection is completed, when the vacuum sampling tube is removed, with the cooperation of the third spring, the movable plate and the intercepting plate, the pressing effect on the hose can be realized, so as to obstruct blood flow and avoid blood spillage;

[0018] 3. During the use of the experimental monkey pathogen detection device, the puncture needle can be fixed through the positioning seat, without manual assistance for fixation. And with the cooperation of the first spring and the movable frame, it can ensure that the positioning seat is always in contact with and positioned on the arm of the experimental monkey, thus effectively ensuring the stability of the puncture needle. Brief Description of the Drawings

[0019] Figure 1 It is a front view three-dimensional structure schematic diagram of the overall composition of the device of the present invention;

[0020] Figure 2 It is a front view sectional three-dimensional structure schematic diagram of the overall composition of the device of the present invention;

[0021] Figure 3 It is a three-dimensional structure schematic diagram of the composition of the auxiliary support mechanism of the present invention;

[0022] Figure 4 It is a front view exploded three-dimensional structure schematic diagram of the positioning mechanism and the vacuum sampling tube of the present invention;

[0023] Figure 5 It is a rear view three-dimensional structure schematic diagram of the positioning mechanism and the intercepting mechanism of the present invention;

[0024] Figure 6 It is a front view sectional three-dimensional structure schematic diagram of the positioning mechanism and the intercepting mechanism of the present invention without the vacuum sampling tube installed.

[0025] In the figure: 1. Ring sleeve; 101. Controller; 102. Storage battery; 103. Air pump; 104. Fixed airbag; 105. Ring airbag; 2. Auxiliary support mechanism; 201. Bracket; 202. Cross bar; 203. Slide block; 204. Ear plate; 205. Movable frame; 206. Circular plate; 207. First spring; 208. Positioning seat; 3. Puncture needle; 4. Hose; 5. Blood drainage needle; 6. Fixed plate; 7. Positioning mechanism; 701. Support seat; 702. Groove; 703. Top plate; 704. Guide rod; 705. Second spring; 8. Interception mechanism; 801. Movable plate; 802. Interception plate; 803. Slide rod; 804. Third spring; 805. Vertical plate; 9. Vacuum sampling tube. Detailed implementation manner

[0026] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0027] Please refer to Figures 1 - 6 , the present invention provides a technical solution: an experimental monkey pathogen detection device, including a ring sleeve 1 and a fixed plate 6. The right side of the ring sleeve 1 is fixed with the fixed plate 6. A positioning mechanism 7 is installed on the fixed plate 6. After the vacuum sampling tube 9 is fixed, under the action of the second spring 705 and the third spring 804, the vertical plate 805, the movable plate 801 and the interception plate 802 move forward a certain distance, so that the interception plate 802 is separated from the hose 4, and blood can flow normally in the hose 4. When the vacuum sampling tube 9 is disassembled, under the action of the third spring 804, the interception plate 802 presses the hose 4 to hinder blood flow.

[0028] The upper end surface of the ring sleeve 1 is provided with a controller 101, a storage battery 102 and an air pump 103, and the controller 101, the storage battery 102 and the air pump 103 are distributed in sequence from front to back on the ring sleeve 1, and the controller 101 is electrically connected to both the storage battery 102 and the air pump 103; the air pump 103 is connected to the fixed airbag 104 and the ring airbag 105 through a conduit, and the fixed airbag 104 and the ring airbag 105 are communicated, and pressure sensors are installed in both the fixed airbag 104 and the ring airbag 105; the fixed airbag 104 is symmetrically distributed about the center line of the ring sleeve 1, and the fixed airbag 104 is an arc-shaped structure;

[0029] When using this experimental monkey pathogen detection device, such as Figures 1 - 6As shown, after the experimental monkey's body is fixed, the annular sleeve 1 is put on the monkey's arm. The opening on the annular sleeve 1 facilitates observing the vein position to determine the installation position of the annular sleeve 1. After the position of the annular sleeve 1 is determined, the controller 101 is used to control the air pump 103 to start, so as to inflate the fixing airbag 104 and the annular airbag 105, making the fixing airbag 104 and the annular airbag 105 expand. The expansion of the fixing airbag 104 can fix the annular sleeve 1 to the monkey's arm, and the expansion of the annular airbag 105 can act as a tourniquet to compress the blood vessels on the monkey's arm for subsequent blood collection. Moreover, the pressure sensors in the fixing airbag 104 and the annular airbag 105 monitor the air pressure to avoid discomfort to the experimental monkey caused by excessive air pressure;

[0030] An auxiliary support mechanism 2 is also fixed on the annular sleeve 1. The auxiliary support mechanism 2 includes a bracket 201, a cross bar 202, a slider 203, an ear plate 204, a movable frame 205, a circular plate 206, a first spring 207 and a positioning seat 208. The brackets 201 are symmetrically fixed on the annular sleeve 1 from left to right, and a cross bar 202 is fixed on the brackets 201, and a slider 203 is slidably connected to the cross bar 202; an ear plate 204 is fixed on the slider 203, and a movable frame 205 is slidably connected to the ear plate 204; a circular plate 206 is fixed on the movable frame 205, and one end of the circular plate 206 is fixedly connected to one end of the first spring 207, and the other end of the first spring 207 is fixed on the ear plate 204; a positioning seat 208 is fixed on the movable frame 205, and a card slot is opened on the positioning seat 208, and a puncture needle 3 is nested and installed in the card slot on the positioning seat 208; the puncture needle 3 is connected to one end of a hose 4, and the other end of the hose 4 is connected to a blood drainage needle 5; the intercepting mechanism 8 includes a movable plate 801, an intercepting plate 802, a sliding rod 803, a third spring 804 and a vertical plate 805. The movable plate 801 is arranged on the front side of the support seat 701. An intercepting plate 802 is fixed on the movable plate 801. A hose 4 is arranged between the intercepting plate 802 and the support seat 701. Sliding rods 803 are symmetrically fixed on the movable plate 801 from left to right. The sliding rods 803 are slidably connected to the support seat 701, and a third spring 804 is also fixed between the sliding rods 803 and the support seat 701, and the elastic coefficient of the third spring 804 is less than that of the second spring 705. A vertical plate 805 is fixed on the sliding rod 803, and the vertical plate 805 is slidably connected to the support seat 701, and the vertical plate 805 contacts the front end of the vacuum sampling tube 9. At the same time, an anti-slip pad is fixed on the contact surface between the vertical plate 805 and the vacuum sampling tube 9. The intercepting plates 802 are evenly distributed on the movable plate 801, and the cross section of the intercepting plate 802 is a triangular structure;

[0031] When the annular sleeve 1 is sleeved on the experimental monkey's arm, as Figures 1 - 6As shown, when the distance from the positioning seat 208 to the lower inner end of the annular sleeve 1 is less than the diameter of the test monkey's arm, the height of the positioning seat 208 can be adjusted by cooperating with the sliding action between the movable frame 205 and the ear plate 204. Then, with the elastic action of the first spring 207, it can be ensured that the lower end face of the positioning seat 208 always contacts the test monkey's arm. After the annular sleeve 1 is fixed to the test monkey's arm, the puncture needle 3 is nested and installed with the positioning seat 208. And by pulling the movable plate 801 and cooperating with the sliding action between the sliding rod 803 and the support seat 701, the stability of the movement of the movable plate 801 is ensured, so that the intercepting plate 802 is separated from the support seat 701. Then, the hose 4 is placed between the intercepting plate 802 and the support seat 701, and the movable plate 801 is released. At this time, under the elastic action of the third spring 804, the movable plate 801 and the intercepting plate 802 are reset to press the hose 4. By cooperating with the triangular cross-sectional structure of the intercepting plate 802, the pressure can be concentrated, so that the hose 4 is deformed by force and blocked. Then, the puncture needle 3 and the positioning seat 208 are pushed, and by cooperating with the sliding action between the slider 203 and the cross bar 202, the puncture needle 3 and the positioning seat 208 can be moved, so that the puncture needle 3 pierces into the blood vessel on the test monkey's arm;

[0032] The positioning mechanism 7 includes a support seat 701, a groove 702, a top plate 703, a guide rod 704 and a second spring 705. The support seat 701 is fixed on the fixing plate 6. An intercepting mechanism 8 is connected to the support seat 701. A groove 702 is formed in the support seat 701. A vacuum sampling tube 9 is placed in the groove 702. A top plate 703 is arranged at the rear side of the support seat 701 and contacts the rear end of the vacuum sampling tube 9. And an anti-slip pad is fixed on the contact surface between the top plate 703 and the vacuum sampling tube 9. On the side of the top plate 703 close to the support seat 701, guide rods 704 are symmetrically fixed on the left and right. The guide rods 704 are slidably connected with the support seat 701. One end of the guide rod 704 is fixed to one end of the second spring 705, and the other end of the second spring 705 is fixed in the support seat 701;

[0033] After the puncture needle 3 pierces into the blood vessel on the test monkey's arm, as Figures 1 - 6As shown, the blood drainage needle 5 is inserted into the vacuum sampling tube 9. At this time, since the hose 4 is deformed by force and blocked, blood will not enter the vacuum sampling tube 9 through the hose 4 and the blood drainage needle 5. Then, by pulling the top plate 703 and cooperating with the sliding action between the guide rod 704 and the support base 701, the stability of the movement of the top plate 703 is ensured, so as to adjust the distance between the top plate 703 and the vertical plate 805. Then, the vacuum sampling tube 9 is placed in the groove 702 between the top plate 703 and the vertical plate 805, and the top plate 703 is released. At this time, under the action of the second spring 705, the top plate 703 moves to press the vacuum sampling tube 9. When both the top plate 703 and the vertical plate 805 are in contact with the vacuum sampling tube 9, the pressing and limiting of the vacuum sampling tube 9 can be realized. And when the top plate 703 and the vertical plate 805 are in contact, at this time, since the second spring 705 is in a contracted state and the elastic coefficient of the second spring 705 is greater than the elastic coefficient of the third spring 804, the vertical plate 805 will move forward a certain distance under the elastic action of the second spring 705, so that the movable plate 801 and the intercepting plate 802 move forward a certain distance, and then the intercepting plate 802 is separated from the hose 4, relieving the pressure on the hose 4. The hose 4 resets under its own elastic action, thus relieving the blocking effect. At this time, under the action of the vacuum inside the vacuum sampling tube 9, the blood enters the vacuum sampling tube 9 through the puncture needle 3, the hose 4 and the blood drainage needle 5 and is collected. And at this time, the whole blood collection mechanism is fixed to the test monkey's arm, without the need for manual support, liberating the hands of the staff and improving the convenience of blood collection. And when it is necessary to replace the vacuum sampling tube 9, according to the above principle, by pulling the top plate 703, at this time, under the action of the third spring 804, the movable plate 801 and the intercepting plate 802 reset to press the hose 4 to prevent blood from flowing. Then, the vacuum sampling tube 9 is removed, and the vacuum sampling tube 9 is separated from the blood drainage needle 5, and then the vacuum sampling tube 9 can be replaced and moved down for blood collection operation. This is the working principle of the test monkey pathogen detection device.

[0034] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An experimental monkey pathogen detection device, comprising an annular sleeve (1) and a fixing plate (6). The fixing plate (6) is fixed to the right side of the annular sleeve (1). It is characterized in that: A positioning mechanism (7) is installed on the fixed plate (6). The positioning mechanism (7) includes a support base (701), a groove (702), a top plate (703), a guide rod (704), and a second spring (705). The support base (701) is fixed on the fixed plate (6). A cut-off mechanism (8) is connected to the support base (701). A groove (702) is formed in the support base (701). A vacuum sampling tube (9) is placed in the groove (702). A top plate (703) is arranged at the rear side of the support base (701), and the top plate (703) contacts the rear end of the vacuum sampling tube (9). An anti-slip pad is fixed on the contact surface between the top plate (703) and the vacuum sampling tube (9). Guide rods (704) are symmetrically fixed on the left and right sides of the top plate (703) near the support base (701). The guide rods (704) are slidably connected to the support base (701). One end of the guide rod (704) is fixed to the second spring (705), and the other end of the second spring (705) is fixed in the support base (701). The cut-off mechanism (8) includes a movable plate (801), a cut-off plate (802), a slide rod (803), a third spring (804), and a vertical plate (805). The movable plate (801) is arranged at the front side of the support base (701). A cut-off plate (802) is fixed on the movable plate (801). A hose (4) is arranged between the cut-off plate (802) and the support base (701). Slide rods (803) are symmetrically fixed on the left and right sides of the movable plate (801). The slide rods (803) are slidably connected to the support base (701). A third spring (804) is also fixed between the slide rod (803) and the support base (701), and the elastic coefficient of the third spring (804) is less than that of the second spring (705). A vertical plate (805) is fixed on the slide rod (803), and the vertical plate (805) is slidably connected to the support base (701). The vertical plate (805) contacts the front end of the vacuum sampling tube (9). An anti-slip pad is fixed on the contact surface between the vertical plate (805) and the vacuum sampling tube (9). An air pump (103) is installed on the upper end surface of the annular sleeve (1). The air pump (103) is connected to a fixed airbag (104) and an annular airbag (105) through a conduit. The fixed airbag (104) and the annular airbag (105) are connected through, and pressure sensors are installed in both the fixed airbag (104) and the annular airbag (105). An auxiliary support mechanism (2) is also fixed on the annular sleeve (1). The auxiliary support mechanism (2) includes a bracket (201), a cross bar (202), a slider (203), an ear plate (204), a movable frame (205), a circular plate (206), a first spring (207), and a positioning seat (208). The brackets (201) are symmetrically fixed on the left and right sides of the annular sleeve (1). A cross bar (202) is fixed on the bracket (201), and a slider (203) is slidably connected to the cross bar (202).

2. The experimental monkey pathogen detection device according to claim 1, wherein: A controller (101), a storage battery (102) and an air pump (103) are installed on the upper end face of the annular sleeve (1), and the controller (101), the storage battery (102) and the air pump (103) are sequentially distributed on the annular sleeve (1) from front to back, and the controller (101) is electrically connected to both the storage battery (102) and the air pump (103).

3. An experimental monkey pathogen detection device according to claim 1, characterized in that: The fixed airbag (104) is symmetrically distributed left and right with respect to the center line of the annular sleeve (1), and the fixed airbag (104) is of an arc-shaped structure.

4. An experimental monkey pathogen detection device according to claim 1, characterized in that: An ear plate (204) is fixed on the slider (203), and a movable frame (205) is slidably connected to the ear plate (204).

5. The experimental monkey pathogen detection device according to claim 1, characterized in that: A circular plate (206) is fixed on the movable frame (205), and the circular plate (206) is fixedly connected to one end of a first spring (207), and the other end of the first spring (207) is fixed on the ear plate (204).

6. The experimental monkey pathogen detection device according to claim 1, wherein: A positioning seat (208) is fixed on the movable frame (205), a clamping groove is formed in the positioning seat (208), and a puncturing needle (3) is nested and installed in the clamping groove of the positioning seat (208).

7. An experimental monkey pathogen detection device according to claim 6, characterized in that: The puncturing needle (3) is connected to one end of a hose (4), and the other end of the hose (4) is connected to a blood drainage needle (5).

8. An experimental monkey pathogen detection device according to claim 1, characterized in that: The intercepting plates (802) are equidistantly distributed on the movable plate (801), and the cross section of the intercepting plate (802) is of a triangular structure.

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