Nucleic acid extraction and amplification detection analyzer convenient to clean

Abstract

The invention relates to a nucleic acid extraction amplification detection analyzer convenient to clean, and belongs to the technical field of nucleic acid extraction. Comprising an instrument body, a rotating disc, a lifting mechanism, a cleaning mechanism, a magnetic bar, a clamping disc and a plurality of containing boxes, a motor is arranged on one side of the bottom of the instrument body, the output end of the motor is connected with the rotating disc, the containing boxes are circularly arranged and clamped to the top face of the rotating disc, and a connecting rod is arranged at the top of the instrument body; the cleaning mechanism is installed on the bottom face of the connecting rod, the magnetic bar is installed on the inner top face of the cleaning mechanism, the lifting mechanism is installed at the bottom of the instrument body and corresponds to the cleaning mechanism, the rotating disc rotates to enable the containing boxes to sequentially correspond to the lifting end of the lifting mechanism, and the lifting mechanism lifts to enable solutions contained in the containing boxes to make contact with the magnetic bar. The nucleic acid extraction instrument solves the problem that cleaning dead corners are prone to occurring when an existing nucleic acid extraction instrument is cleaned.

Description

Technical Field

[0001] The invention belongs to the technical field of nucleic acid extraction, and in particular relates to a nucleic acid extraction, amplification, detection and analysis instrument which is easy to clean. Background Art

[0002] Nucleic acid is a biological macromolecule composed of many nucleotides. It is one of the most basic substances of life and is widely present in all animal and plant cells and microorganisms. Nucleic acids in organisms often combine with proteins to form nucleoproteins. They are also the carriers of genetic information and the most important bioinformatics molecules. They have good application prospects in epidemiological surveys and are also very suitable for use in agriculture, food safety, biomedicine and other fields.

[0003] Early experiments were completed through manual extraction and amplification, which was time-consuming and the experimental results were easily affected by individual operational differences among experimenters. However, with the development of industry, some nucleic acid extraction and amplification detection equipment began to appear to solve the problem of differences in experimental results.

[0004] At present, when nucleic acids are extracted, cells need to be broken, and then the nucleic acids are adsorbed by magnetic beads, and then the nucleic acids are separated from the broken cells by adsorbing the magnetic beads through a magnetic rod. The process of nucleic acid extraction by magnetic beads is as follows: lysis: adding lysis solution to the sample to release nucleic acids; adsorption and binding: adding magnetic beads to the sample lysis solution, and the nucleic acids are adsorbed and bound to the magnetic beads; washing: pulling the magnetic beads and nucleic acids into the washing solution, cleaning the magnetic beads and nucleic acids from nucleic acid impurities, and removing nucleic acid impurities; elution: pulling the magnetic beads and nucleic acids into the elution solution, separating the nucleic acids from the magnetic beads, and obtaining purified nucleic acids. Among them, each step is crucial, and any problem in any step will affect the entire nucleic acid extraction process.

[0005] Therefore, in order to avoid cross infection during the nucleic acid extraction process, after a batch of nucleic acid extraction is completed, all magnetic rods need to be cleaned and disinfected between each batch of experiments. However, when cleaning the current nucleic acid extractor, it is generally done by manually spraying disinfectant alcohol and then wiping it carefully. It is very easy for cleaning dead corners to appear due to human negligence, causing sample contamination. Summary of the invention

[0006] In order to solve the above problems existing in the prior art, the present invention provides a nucleic acid extraction, amplification, detection and analysis instrument that is easy to clean, which solves the problem that the existing nucleic acid extraction instruments are prone to cleaning dead corners during cleaning.

[0007] The object of the present invention can be achieved by the following technical scheme: a nucleic acid extraction, amplification, detection and analysis instrument that is easy to clean, comprising an instrument body, a turntable, a lifting mechanism, a cleaning mechanism, a magnetic rod, a clamping plate and a plurality of placement boxes, a motor is arranged on one side of the bottom of the instrument body, the output end of the motor is connected to the turntable, a plurality of the placement boxes are arranged in a circle and clamped on the top surface of the turntable, a connecting rod is provided on the top of the instrument body, the cleaning mechanism is installed on the bottom surface of the connecting rod, the magnetic rod is installed on the inner top surface of the cleaning mechanism, the lifting mechanism is installed on the bottom of the instrument body and is arranged corresponding to the cleaning mechanism, the turntable rotates to make the placement boxes correspond to the lifting end of the lifting mechanism in turn, and the lifting mechanism lifts the solution placed in the placement box to contact the magnetic rod;

[0008] The cleaning mechanism includes a hollow shell with an opening downward, a fixed plate and a cleaning plate, the fixed plate is installed on the inner top surface of the hollow shell, the magnetic bar is installed on the bottom of the fixed plate, the cleaning plate is slidably connected to the inner wall of the hollow shell and is located below the fixed plate, a cleaning hole is provided on the cleaning plate, the cleaning hole is arranged corresponding to the magnetic bar, an infusion groove and a liquid extraction groove are provided in the cleaning plate, the infusion groove is connected to the cleaning hole, and the liquid extraction groove is connected to the infusion groove.

[0009] As a preferred technical solution of the present invention, the side wall of the cleaning hole is provided with bristles, and the bristles abut against the outer side wall of the magnetic rod.

[0010] As a preferred technical solution of the present invention, the turntable is provided with a plurality of card slots, the card slots are open slots and the top surfaces of the card slots are provided with step surfaces, the top surfaces of the card slots are provided with a card connecting plate, and the placement box is installed on the top surface of the card connecting plate.

[0011] As a preferred technical solution of the present invention, the inner side wall of the hollow shell is also provided with a liquid spray hole and a liquid extraction hole. The clamping plate is sealed and abutted against the bottom surface of the hollow shell when lifted by the lifting mechanism. The liquid spray hole is used to spray cleaning liquid into the liquid spray hole, and the liquid extraction hole is used to suck the liquid in the hollow shell.

[0012] As a preferred technical solution of the present invention, the cleaning mechanism further includes an exhaust fan, which is installed on the outer side wall of the hollow shell and located on one side of the liquid spray hole.

[0013] As a preferred technical solution of the present invention, a detection mechanism is provided on the bottom surface of the fixing plate, and the detection mechanism is used to detect the solution residue in the hollow shell.

[0014] As a preferred technical solution of the present invention, the cleaning mechanism further comprises an electric push rod, which is mounted on the inner top surface of the hollow shell, and the output end of the electric push rod is connected to the cleaning plate.

[0015] As a preferred technical solution of the present invention, the magnetic bar is an electromagnetic bar.

[0016] As a preferred technical solution of the present invention, the lifting mechanism includes a lifting motor, a screw rod, a slider and a slide rail. The lifting motor is installed at the bottom of the instrument body, the screw rod is connected to the output end of the lifting motor, the slide rail is installed on the side wall of the instrument body, the slider is spirally connected to the screw rod, and the slider is slidably connected to the slide rail.

[0017] As a preferred technical solution of the present invention, a positioning column is provided on the top surface of the slider, a positioning hole is provided on the bottom surface of the clamping plate, the positioning column is arranged corresponding to the positioning hole, and a pressure sensor is provided on the top surface of the positioning column.

[0018] The beneficial effects of the present invention are as follows: when cleaning, the cleaning plate slides downward, allowing the cleaning holes to pass through the side walls of the magnetic rod in sequence from top to bottom, and at the same time, cleaning liquid is input into the infusion slot to rinse the magnetic rod, and the suction slot starts to suck the liquid flushed out of the infusion slot after the cleaning liquid is input into the infusion slot for a period of time to clean the magnetic rod, and the waste liquid after cleaning is discharged, thereby completing the cleaning of the magnetic rod, avoiding cross infection during nucleic acid extraction, and solving the problem of cleaning dead corners in existing nucleic acid extractors during cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to facilitate understanding by those skilled in the art, the present invention is further described below with reference to the accompanying drawings.

[0020] Figure 1 It is a structural schematic diagram of the present invention;

[0021] Figure 2 It is a schematic diagram of the lifting mechanism structure of the present invention;

[0022] Figure 3 It is a schematic diagram of the structure of the turntable of the present invention;

[0023] Figure 4 This is a schematic diagram of the cleaning mechanism structure of the present invention;

[0024] Figure 5 This is a schematic diagram of the cleaning plate structure of the present invention;

[0025] Main component symbols

[0026] In the figure: 1. Instrument body; 2. Turntable; 21. Card slot; 22. Card plate; 221. Positioning hole; 3. Lifting mechanism; 31. Lifting motor; 32. Screw rod; 33. Sliding block; 34. Slide rail; 4. Cleaning mechanism; 41. Hollow shell; 411. Spray hole; 412. Extraction hole; 42. Fixing plate; 43. Cleaning plate; 431. Infusion trough; 432. Extraction trough; 433. Brush; 44. Exhaust fan; 5. Magnetic rod; 6. Placement box; 7. Motor. DETAILED DESCRIPTION

[0027] In order to further explain the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in conjunction with the accompanying drawings and preferred embodiments.

[0028] See also Figure 1-Figure 5 The present embodiment provides a nucleic acid extraction, amplification, detection and analysis instrument that is easy to clean, comprising an instrument body 1, a turntable 2, a lifting mechanism 3, a cleaning mechanism 4, a magnetic rod 5 and a plurality of placement boxes 6. A motor 7 is arranged on one side of the bottom of the instrument body 1. The turntable 2 is mounted at the output end of the motor 7 and rotates under the drive of the motor 7. The plurality of placement boxes 6 are arranged in a circle and snap-fitted to the top surface of the turntable 2. A connecting rod is provided on the top of the instrument body 1. The cleaning mechanism 4 is mounted on the bottom surface of the connecting rod. The magnetic rod 5 is mounted on the inner top surface of the cleaning mechanism 4. The lifting mechanism 3 is mounted on the bottom of the instrument body 1 and is arranged corresponding to the cleaning mechanism 4. When the turntable 2 rotates, the placement boxes 6 will be located above the lifting end of the lifting mechanism 3 in sequence. At this time, the turntable 2 stops rotating, and the lifting mechanism 3 will lift the placement box 6 into the cleaning mechanism 4. In the placement box 6, solutions such as lysate and washing solution are placed in sequence according to the nucleic acid extraction process, so that the solution in the placement box 6 contacts the magnetic rod 5, and the magnetic rod 5 adsorbs the magnetic beads in the placement box 6 to complete the nucleic acid extraction process.

[0029] After the nucleic acid extraction is completed, the magnetic rod 5 needs to be cleaned to avoid cross infection and affect the subsequent nucleic acid extraction process. The cleaning mechanism 4 includes a hollow shell 41 with an opening downward, a fixed plate 42 and a cleaning plate 43. The fixed plate 42 is installed on the inner top surface of the hollow shell 41, and the magnetic rod 5 is installed on the bottom surface of the fixed plate 42. The cleaning plate 43 is slidably connected to the inner side wall of the hollow shell 41 and is located below the fixed plate 42. A cleaning hole is opened on the cleaning plate 43, and the cleaning hole is correspondingly arranged at the magnetic rod 5. At the same time, an infusion groove 431 and a liquid extraction groove 432 are also arranged on the cleaning plate 43. The infusion groove 431 is connected to the cleaning hole, and the liquid extraction groove 432 is connected to the infusion groove 431. When the nucleic acid is extracted During the process, only the bottom of the magnetic rod 5 will be located in the placement box 6. Therefore, when cleaning the magnetic rod 5, only the bottom of the magnetic rod 5 needs to be cleaned. Therefore, after a batch of nucleic acid extraction is completed, during cleaning, the cleaning plate 43 slides downward to allow the cleaning holes to pass through the side walls of the magnetic rod 5 from top to bottom. At the same time, cleaning liquid will be input into the infusion groove 431 to rinse the magnetic rod 5. Moreover, the suction groove 432 starts to suck the liquid flushed out of the infusion groove 431 after the cleaning liquid is input into the infusion groove 431 for a period of time to clean the magnetic rod 5, and the waste liquid after cleaning is discharged, thereby completing the cleaning of the magnetic rod 5 and avoiding cross infection during nucleic acid extraction.

[0030] In order to better clean the magnetic rod 5, in the present embodiment, the side wall of the cleaning hole is provided with bristles 433, and the bristles 433 abut against the outer wall of the magnetic rod 5. When the cleaning plate 43 slides downward, the bristles 433 in the cleaning hole will abut against the outer wall of the magnetic rod 5, and at the same time, the magnetic rod 5 will be cleaned by flushing with the cleaning liquid, so as to better remove the solution attached to the magnetic rod 5, thereby avoiding the occurrence of cross infection due to the failure to clean the magnetic rod 5 during the next batch of nucleic acid extraction.

[0031] In order to ensure stability during the nucleic acid extraction process, in one embodiment, the turntable 2 is provided with a plurality of slots 21, which are open slots and the top surface of the slots 21 is provided with a step surface, and the top surface of the slots 21 is provided with a snap-in plate 22, and the placement box 6 is installed on the top surface of the snap-in plate 22. During the nucleic acid extraction process, it is necessary to allow a plurality of placement boxes 6 to rise to the cleaning mechanism 4 in sequence so that the magnetic beads in the placement box 6 are adsorbed by the magnetic rod 5 to complete the extraction process. Therefore, during the nucleic acid extraction process, the lifting mechanism 3 needs to lift the placement box 6 into the cleaning mechanism 4 and then return to the turntable 2. During this rising and falling process, it is necessary to ensure that the placement box 6 corresponds to the magnetic rod 5 after the placement box 6 rises to its position, and avoids the occurrence of deviation. At the same time, when descending, the snap-in plate 22 is also required to be snapped into the slot 21 to avoid the occurrence of positioning error during the next lifting. Therefore, a snap-in slot is provided on the turntable 2 to determine the position of each placement box 6 during lifting, ensuring that the placement box 6 can accurately correspond to the magnetic rod 5 during the lifting process to avoid the occurrence of position deviation.

[0032] In the process of nucleic acid extraction, in addition to cleaning the magnetic rod 5, it is usually necessary to clean the inside of the instrument. However, the reason for cleaning the inside of the instrument is that during the extraction process, the solution in the placement box 6 will fall into the instrument, so it needs to be cleaned. Therefore, in order to better complete the cleaning of the instrument, in one embodiment, the inner wall of the hollow shell 41 is further provided with a liquid injection hole 411 and a liquid extraction hole 412. The clamping plate 22 is sealed and abutted against the bottom surface of the hollow shell 41 under the lifting of the lifting mechanism 3. The liquid injection hole 411 is used to inject liquid into the liquid injection hole 412. Cleaning liquid is sprayed inside 411, and the liquid extraction hole 412 is used to suck the liquid in the hollow shell 41. Since the present invention is a small automatic nucleic acid extractor, the extraction and purification process is automatically completed using packaged supporting reagents. Therefore, the supporting reagents are placed in the placement box 6. Therefore, during the process of nucleic acid extraction, the placement box 6 needs to be removed and the supporting reagents are placed before being reinstalled on the clamping plate 22. Therefore, the placement box 6 can be removed for separate cleaning. Therefore, when cleaning the inside of the instrument, it is only necessary to clean the position where the solution drips during the nucleic acid extraction process. Since the position of the magnetic bar 5 does not move when the nucleic acid is extracted, the position where the solution drips will only fall on the turntable 2, and the turntable 2 is not located inside the instrument. Therefore, it can be easily wiped. Although the position of the magnetic bar 5 does not change during the nucleic acid extraction process, in order to improve the efficiency of nucleic acid extraction, it is usually necessary to allow the magnetic bar 5 to reciprocate up and down in the test tube to form a stirring effect on the liquid in the test tube to improve the efficiency of nucleic acid binding or nucleic acid washing or nucleic acid elution. Therefore, during the nucleic acid extraction process, the solution will also splash on The hollow shell 41 is therefore required to have its side walls cleaned. After the nucleic acid extraction is completed, the placement box 6 is removed, and the lifting mechanism 3 lifts the snap-on plate 22 to the bottom surface of the hollow shell 41, allowing the snap-on plate 22 to close the hollow shell 41. Cleaning liquid is then sprayed out from the liquid spray hole 411 to clean the hollow shell 41. After flushing is completed, the cleaning liquid in the shell is extracted through the liquid extraction hole 412, thereby completing the cleaning process of the hollow shell 41, thereby avoiding mixing between samples and reducing sample contamination.

[0033] In order to improve the cleaning efficiency of the hollow shell 41, in one embodiment, the cleaning mechanism 4 also includes an exhaust fan 44, which is installed on the outer wall of the hollow shell 41 and is located on one side of the liquid spray hole 411. After the flushing of the hollow shell 41 is completed, the exhaust fan 44 blows gas into the hollow shell 41 to remove the residual liquid in the hollow shell 41, so as to dry the hollow shell 41, reduce possible corrosion and bacterial growth, and effectively avoid the introduction of pollutants due to residual liquid in subsequent operations.

[0034] In the process of extracting nucleic acids, the components of the lysis solution, washing solution and elution solution are not the same, and when extracting nucleic acids, it is usually necessary to allow the magnetic beads to fully combine with the nucleic acids during washing and elution. At this time, the magnetic bar 5 needs to move up and down to a large extent to make the magnetic beads fully contact with the nucleic acids. Therefore, the solution sputtered into the hollow shell 41 at this time will be more than the solution sputtered by the lysis solution. At the same time, since the position of the magnetic beads adsorbed on the magnetic bar 5 is different each time, the amount of sputtered solution will also be different. Therefore, in order to better clean the sputtered solution in the instrument, in one embodiment, a detection mechanism is provided on the bottom surface of the fixed plate 42, and the detection mechanism is used to detect the solution residue in the hollow shell 41. The amount of solution sputtered during each nucleic acid extraction process is detected by the detection mechanism, so that the content of the corresponding solution cleaning solution can be increased when the instrument is better cleaned, thereby better completing the process of cleaning the instrument, thereby improving the cleaning efficiency.

[0035] In order to ensure the cleaning effect of the magnetic rod 5, in one embodiment, the cleaning mechanism 4 also includes an electric push rod, which is installed on the inner top surface of the hollow shell 41. The output end of the electric push rod is connected to the cleaning plate 43. When cleaning, the electric push rod will drive the cleaning plate 43 to slide, so that the bristles 433 in the cleaning hole can clean the magnetic rod 5, thereby removing the residual solution on the magnetic rod 5, avoiding cross infection during the nucleic acid extraction process.

[0036] In order to better adsorb nucleic acid to ensure the extraction of nucleic acid, in one embodiment, the magnetic bar 5 is an electromagnetic bar 5. In the process of using magnetic beads to extract nucleic acid, it is necessary to allow the magnetic beads to adsorb nucleic acid, and then use the magnetic bar 5 to adsorb the magnetic beads to complete the extraction process. However, the part for adsorbing magnetic beads is generally located at the bottom of the magnetic bar 5 set, which has a relatively small area. The magnetic beads are stacked at the bottom of the magnetic bar 5. The outer layer of magnetic beads is too weak to attract and will easily fall off when the magnetic bar 5 moves, resulting in some magnetic beads being unable to be moved to the next test tube, thereby affecting the result of nucleic acid extraction. Therefore, in order to avoid the above situation, the magnetic bar 5 uses an electromagnetic bar 5 to adsorb the magnetic beads. The magnetic force of the electromagnetic bar 5 can be changed by changing the current on the electromagnetic bar 5, thereby ensuring that the magnetic beads can be adsorbed and the magnetic beads can be prevented from falling off during the adsorption process, thereby ensuring the effect of nucleic acid extraction.

[0037] In order to ensure that the placement box 6 can accurately correspond to the magnetic rod 5 to complete the extraction of nucleic acid, in one embodiment, the lifting mechanism 3 includes a lifting motor 31, a screw rod 32, a slider 33 and a slide rail 34. The lifting motor 31 is installed at the bottom of the instrument body 1, the screw rod 32 is connected to the output end of the lifting motor 31, and the slide rail 34 is installed on the side wall of the instrument body 1. The slider 33 is spirally connected to the screw rod 32, and the slider 33 is slidably connected to the slide rail 34. When the turntable 2 rotates into place, the lifting motor 31 rotates through the screw rod 32 to drive the slider 33 to slide on the slide rail 34, so that the slider 33 drives the clamping plate 22 to move upward to correspond to the hollow shell 41, so that the magnetic rod 5 can complete the adsorption of magnetic beads, thereby completing the extraction of nucleic acid.

[0038] In order to ensure that the placement box 6 can accurately correspond to the magnetic rod 5 during the lifting process, in one embodiment, a positioning column is provided on the top surface of the slider 33, and a positioning hole 221 is provided on the bottom surface of the clamping plate 22. The positioning column and the positioning hole 221 are arranged correspondingly, and a pressure sensor is provided on the top surface of the positioning column. When the lifting mechanism 3 is lifting, the slider 33 will move up to drive the clamping plate 22 to move. In order to avoid position deviation when the clamping plate 22 abuts against the slider 33, which makes it impossible to accurately position the placement box 6 and the magnetic rod 5, during the lifting process, the positioning hole 221 on the bottom surface of the clamping plate 22 will be clamped with the positioning column. If the pressure sensor detects a pressure value at this time, it means that the positioning column is not located in the positioning hole 221, but is offset. When the positioning column is located in the positioning hole 221, the pressure sensor will not detect the pressure value. Therefore, the design of the pressure sensor, the positioning column and the positioning hole 221 can effectively prevent the placement box 6 from being misplaced during the lifting process, thereby ensuring that the placement box 6 can accurately correspond to the magnetic rod 5.

[0039] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A nucleic acid extraction, amplification, detection and analysis instrument that is easy to clean, characterized in that: It includes an instrument body, a turntable, a lifting mechanism, a cleaning mechanism, a magnetic rod, a clamping plate and a plurality of placement boxes. A motor is arranged on one side of the bottom of the instrument body, and the output end of the motor is connected to the turntable. A plurality of placement boxes are arranged in a circle and clamped on the top surface of the turntable. A connecting rod is provided on the top of the instrument body. The cleaning mechanism is installed on the bottom surface of the connecting rod. The magnetic rod is installed on the inner top surface of the cleaning mechanism. The lifting mechanism is installed on the bottom of the instrument body and is arranged corresponding to the cleaning mechanism. The turntable rotates to make the placement boxes correspond to the lifting end of the lifting mechanism in turn. The lifting mechanism lifts the solution placed in the placement box to contact the magnetic rod. The cleaning mechanism includes a hollow shell with an opening downward, a fixed plate and a cleaning plate, the fixed plate is installed on the inner top surface of the hollow shell, the magnetic bar is installed on the bottom of the fixed plate, the cleaning plate is slidably connected to the inner wall of the hollow shell and is located below the fixed plate, a cleaning hole is provided on the cleaning plate, the cleaning hole is arranged corresponding to the magnetic bar, an infusion groove and a liquid extraction groove are provided in the cleaning plate, the infusion groove is connected to the cleaning hole, and the liquid extraction groove is connected to the infusion groove.

2. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 1, characterized in that: The side wall of the cleaning hole is provided with bristles, and the bristles abut against the outer side wall of the magnetic rod.

3. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 1, characterized in that: The turntable is provided with a plurality of card slots, the card slots are open slots and the top surfaces of the card slots are provided with step surfaces, the top surfaces of the card slots are provided with card connection plates, and the placement box is installed on the top surface of the card connection plates.

4. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 3, characterized in that: The inner side wall of the hollow shell is also provided with a liquid spraying hole and a liquid extraction hole. The clamping plate is sealed and abutted against the bottom surface of the hollow shell under the lifting of the lifting mechanism. The liquid spraying hole is used to spray cleaning liquid into the liquid spraying hole, and the liquid extraction hole is used to suck the liquid in the hollow shell.

5. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 4, characterized in that: The cleaning mechanism also includes an exhaust fan, which is installed on the outer side wall of the hollow shell and located on one side of the liquid spraying hole.

6. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 4, characterized in that: A detection mechanism is provided on the bottom surface of the fixing plate, and the detection mechanism is used to detect the solution residue in the hollow shell.

7. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 1, characterized in that: The cleaning mechanism further comprises an electric push rod, which is mounted on the inner top surface of the hollow shell, and an output end of the electric push rod is connected to the cleaning plate.

8. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 1, characterized in that: The magnetic bar is an electromagnetic bar.

9. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 3, characterized in that: The lifting mechanism includes a lifting motor, a lead screw, a slider and a slide rail. The lifting motor is installed at the bottom of the instrument body, the lead screw is connected to the output end of the lifting motor, the slide rail is installed on the side wall of the instrument body, the slider is spirally connected to the lead screw, and the slider is slidably connected to the slide rail.

10. The easy-to-clean nucleic acid extraction, amplification, detection and analysis instrument according to claim 9, characterized in that: A positioning column is provided on the top surface of the sliding block, a positioning hole is provided on the bottom surface of the clamping plate, the positioning column is arranged corresponding to the positioning hole, and a pressure sensor is provided on the top surface of the positioning column.

Images