Constant-temperature horizontal electrophoresis device
By designing a horizontal mechanism and a constant temperature mechanism in the electrophoresis device, the horizontal dynamic adjustment and constant temperature control of the electrophoresis tank are solved, and the accuracy and reliability of the experiment are improved.
Patent Information
- Application Number
- CN202411858222.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-17
- Publication Date
- 2025-03-25
AI Technical Summary
Traditional electrophoresis instruments cannot maintain the horizontal state of the electrophoresis tank, resulting in uneven distribution of electrophoresis fluids, affecting the accuracy and reliability of experimental results. At the same time, they lack dynamic adjustment and precise control functions, making it difficult to meet the needs of special medical electrophoresis experiments.
A constant temperature level electrophoresis device is designed, and the horizontal dynamic adjustment and constant temperature control of the electrophoresis tank are realized through the cooperation of the horizontal mechanism and the constant temperature mechanism. The horizontal mechanism includes a base, a power piece and a balance piece, and the horizontal adjustment is achieved through synchronous accuracy control; the constant temperature mechanism includes a refrigeration piece and a heat dissipation piece, and the constant temperature control is achieved through temperature detection and automatic adjustment.
It improves the accuracy and reliability of electrophoresis experiments, ensures the uniform distribution of electrophoresis fluid and the stability of temperature, is suitable for a variety of experimental environments, and meets the needs of special medical electrophoresis experiments.
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Figure CN119688808A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of cell protein analysis equipment, in particular to a constant temperature electrophoresis device. Background Art
[0002] With the continuous advancement of science and technology, the means of medical research and testing are becoming more and more diverse. As an important device for nucleic acid and protein separation and analysis, electrophoresis plays an indispensable role in biomedical research and clinical medicine. However, traditional electrophoresis has some significant defects, which seriously affect the accuracy and reliability of experimental results.
[0003] First, traditional electrophoresis instruments cannot keep the electrophoresis tank horizontal. This causes uneven distribution of the electrophoresis fluid in the electrophoresis tank, which directly affects the separation effect of the sample. Uneven distribution of the electrophoresis fluid will cause inconsistent electric field strength, resulting in different migration speeds of samples at different locations, ultimately affecting the accuracy of the experimental results.
[0004] Secondly, the traditional electrophoresis instrument has high power during the electrophoresis process, which easily causes the temperature of the electrophoresis solution to rise. The high temperature environment has an adverse effect on the separation and analysis of protein and nucleic acid molecules, especially for the separation of some proteins with similar molecular weights. The temperature increase may cause sample denaturation, degradation or aggregation, thus affecting the reliability of the experimental results.
[0005] In addition, existing electrophoresis instruments lack the functions of dynamic adjustment and precise control. During the experiment, the level and temperature of the electrophoresis tank cannot be adjusted in real time according to actual needs, which limits the flexibility and applicability of the experiment. For some special medical electrophoresis experiments, existing equipment is difficult to meet their requirements for precise control and specific environments.
[0006] Finally, the temperature control system of traditional electrophoresis instruments is not perfect. The lack of effective constant temperature control makes it difficult to maintain a stable temperature environment for long-term electrophoresis experiments, which causes trouble for the analysis of some temperature-sensitive samples.
[0007] In view of the above problems, the existing technology needs to be improved urgently. Summary of the invention
[0008] The object of the present invention is to provide a constant-temperature electrophoresis device, which has the advantages of precise level adjustment, stable temperature control and reasonable structural design.
[0009] To achieve the above object, the present invention adopts the following technical solutions:
[0010] The constant temperature horizontal electrophoresis device according to the embodiment of the present invention comprises: a device body, a horizontal mechanism, and a constant temperature mechanism. The device body is provided with a connecting portion, and the connecting portion is arranged at the circumferential edge of the device body; the horizontal mechanism is connected to the connecting portion, and the horizontal mechanism comprises a base, two power members and a balancing member, the two power members and the balancing member are installed on the base, and the balancing member and the two power members are not on the same straight line; the constant temperature mechanism is installed on the device body.
[0011] According to the constant temperature horizontal electrophoresis device of the embodiment of the present invention, the horizontal dynamic adjustment of the electrophoresis tank is realized through the synchronous precision control of the power part, and the constant temperature control of the electrophoresis tank is realized through the synchronous dynamic control of the constant temperature mechanism. The cooperation of the horizontal mechanism and the constant temperature mechanism improves the accuracy and reliability of the electrophoresis device experiment, and at the same time enables the electrophoresis device to be suitable for a variety of environments.
[0012] In addition, the constant temperature electrophoresis device according to the above embodiment of the present invention may also have the following additional technical features:
[0013] In some embodiments of the present invention, the balancing member is configured as a rod extending along a first direction and vertically mounted on the base, and the power member includes a moving part, and the moving part moves along the first direction.
[0014] In some embodiments of the present invention, the balancing member is configured as a power member, three of the power members are mounted on the base, and the power member includes a moving part, and the moving part moves along a first direction.
[0015] In some embodiments of the present invention, one end of the balancing member away from the base is fixed to the connecting part by means of a ball bearing, and one end of the moving part away from the base is fixed to the connecting part by means of a ball bearing, and the device body can move relative to the horizontal mechanism.
[0016] In some embodiments of the present invention, the moving part is configured as a push rod structure, and the output end of the power member is connected to the moving part and drives the moving part to move along the first direction.
[0017] In some embodiments of the present invention, the device body includes: a first main body and a slot body, the first main body is formed with a mounting slot that cooperates with the slot body, the slot body is installed in the mounting slot, and an electrophoresis slot is formed on the slot body, and the electrophoresis slot is used to accommodate samples.
[0018] In some embodiments of the present invention, the device body also includes a second main body portion, which is installed on the first main body portion and fixes the tank body on the first main body portion. A through hole consistent with the opening of the electrophoresis tank is formed on the second main body portion, and the sample enters the electrophoresis tank through the through hole.
[0019] In some embodiments of the present invention, the device body further includes a temperature detection component, which is installed on the first main body and tests the temperature in the electrophoresis tank.
[0020] In some embodiments of the present invention, the constant temperature mechanism includes: a refrigeration component, which is installed on the first main body at a side away from a notch of the installation slot, and the refrigeration component is arranged close to the installation slot.
[0021] In some embodiments of the present invention, the constant temperature mechanism includes a first heat sink and a second heat sink, the first heat sink is mounted on the refrigeration element and is disposed away from the first main body, and the second heat sink is mounted on the first heat sink and is disposed away from the refrigeration element.
[0022] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] Figure 1 Schematic diagram of the structure of a constant temperature electrophoresis device according to an embodiment of the present invention.
[0024] Reference numerals
[0025] 100. Electrophoresis device;
[0026] 1. Device body;
[0027] 11. first main body; 111. connecting portion; 112. mounting groove;
[0028] 12. second main body; 121. through hole;
[0029] 13. tank body; 131. electrophoresis tank;
[0030] 14. Temperature detection parts;
[0031] 2. Horizontal mechanism; 21. Base; 22. The balancing member 22;
[0032] 23. Power parts; 231. Moving parts;
[0033] 3. Constant temperature mechanism; 31. Refrigeration element; 32. First heat dissipation element; 33. Second heat dissipation element. DETAILED DESCRIPTION
[0034] A more detailed description of a constant temperature level electrophoresis device of the present invention will be given below in conjunction with the accompanying drawings, wherein preferred embodiments of the present invention are shown, and it should be understood that those skilled in the art may modify the present invention described herein while still achieving the advantageous effects of the present invention. Therefore, the following description should be understood as being widely known to those skilled in the art, and not as a limitation of the present invention.
[0035] In the description of this specification, "one embodiment" or "some embodiments" etc. means that one or more embodiments of this specification include a specific feature, structure or characteristic described in conjunction with the embodiment. Therefore, the phrases "in one embodiment", "in some embodiments", "in some other embodiments", "in some other embodiments", etc. appearing in different places in this specification do not necessarily refer to the same embodiment, but mean "one or more but not all embodiments", unless otherwise specifically emphasized in other ways.
[0036] In the technical field of cell protein analysis equipment, traditional electrophoresis instruments cannot maintain the level of the electrophoresis tank during the electrophoresis experiment, resulting in uneven distribution of the electrophoresis solution, which in turn affects the separation and analysis of protein and nucleic acid molecules. In order to solve this problem, the present invention proposes a constant temperature horizontal electrophoresis device 100. The electrophoresis device 100 achieves dynamic horizontal adjustment and constant temperature control of the electrophoresis tank during the experiment through the cooperation of the device body 1, the horizontal mechanism 2 and the constant temperature mechanism 3.
[0037] During the electrophoresis process, it is critical to keep the electrophoresis tank horizontal. Conventional electrophoresis instruments cannot dynamically adjust the level of the electrophoresis tank, resulting in uneven distribution of the electrophoresis solution, which affects the experimental results. In order to solve this problem, the present invention designs a constant temperature electrophoresis device 100.
[0038] Embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.
[0039] Please refer to the following Figure 1 A constant temperature electrophoresis device 100 according to an embodiment of the present invention is described.
[0040] According to the constant temperature electrophoresis device 100 of the embodiment of the present invention, Figure 1As shown, the device comprises a main body 1, on which a connecting portion 111 is provided, and the connecting portion 111 is provided at a circumferential edge of the main body 1. A horizontal mechanism 2 is connected to the connecting portion 111, and the horizontal mechanism 2 comprises a base 21, two power members 23 and a balancing member 22, wherein the two power members 23 and the balancing member 22 are mounted on the base 21, and the balancing member 22 and the two power members 23 are not on the same straight line; a constant temperature mechanism 3 is mounted on the main body 1 of the device.
[0041] The device body 1 provides an integral structure, and the connecting portion 111 is used to connect the device body 1 with the horizontal mechanism 2. The horizontal mechanism 2 realizes the horizontal adjustment of the device body 1 through the cooperation of the water base 21, the two power members 23 and the balance member 22. The arrangement of the two power members 23 and the balance member 22 in a non-straight line enables the device body 1 to determine a horizontal plane for the device body 1 by three points to determine a plane, thereby realizing the horizontal adjustment of the device body 1, thereby maintaining the horizontal state of the electrophoresis device 100. The constant temperature mechanism 3 is used to control the temperature of the device body 1 to ensure constant temperature during the electrophoresis process.
[0042] Compared with the prior art, the present invention realizes the dynamic adjustment of the level of the electrophoresis tank 131 by synchronous precision control of the power member 23, and realizes the constant temperature control of the electrophoresis tank 131 by synchronous dynamic control of the constant temperature mechanism 3. The conventional electrophoresis instrument cannot maintain the level of the electrophoresis tank 131 during the electrophoresis process, and the temperature is difficult to maintain in a stable state, resulting in uneven distribution of the electrophoresis liquid, which affects the experimental results. The present invention solves this problem through the cooperation of the horizontal mechanism 2 and the constant temperature mechanism 3, and improves the accuracy and reliability of the electrophoresis experiment.
[0043] In some embodiments of the present invention, Figure 1 As shown, the balance member 22 is configured to move the rod along a first direction (eg Figure 1 The balance member 22 and the two power members 23 cooperate with each other to determine a plane through three points, so that the level of the electrophoresis tank 131 can be dynamically adjusted during the electrophoresis experiment, thereby solving the problem of adjusting the level of the electrophoresis tank 131 in different working environments and the problem of being unable to keep the level during the experiment.
[0044] The balancing member 22 can be implemented by different materials and structures, for example, a metal rod or a high-strength composite rod can be used to ensure its stability and durability during use. The moving part 231 of the power member 23 can adopt a push rod structure driven by a stepping motor, and the precise movement of the moving part 231 along the first direction can be achieved by accurately controlling the stepping angle of the stepping motor. In addition, other types of driving mechanisms, such as linear motors, pneumatic drives, etc., can also be considered to meet the needs under different experimental conditions.
[0045] The present invention provides the balance member 22 and the power member 23 so that the electrophoresis tank 131 can maintain a horizontal state during the experiment, thereby avoiding the problem of uneven distribution of the electrophoresis liquid in the electrophoresis tank 131. Compared with the prior art, the technical solution of the present invention has the following advantages: first, through the precise control of the power member 23, the horizontal dynamic adjustment of the electrophoresis tank 131 is achieved, ensuring the accuracy of the experimental results; second, the design of the balance member 22 and the power member 23 makes the electrophoresis device 100 structure more stable and suitable for different experimental environments; finally, the technical solution of the present invention improves the reliability of the electrophoresis experiment, reduces the error of human adjustment, and improves the experimental efficiency. Therefore, the present invention has significant technical progress and application value in the field of electrophoresis experimental equipment.
[0046] In some embodiments of the present invention, the balancing member 22 is configured as the power member 23, three of the power members 23 are mounted on the water base 21, and the power member 23 includes the moving portion 231, and the moving portion 231 moves along the first direction. Through the cooperation of the three power members 23, the level of the electrophoresis tank 131 can be dynamically adjusted during the electrophoresis process, thereby maintaining the uniform distribution of the electrophoresis liquid in the electrophoresis tank 131. The provision of the three power members 23 can effectively solve the problem that the level of the electrophoresis tank 131 is difficult to maintain during the electrophoresis process, ensure the uniform distribution of the electrophoresis liquid in the electrophoresis tank 131, and thus improve the accuracy and effect of electrophoresis separation.
[0047] Specifically, the power member 23 can be implemented in a variety of ways. For example, the power member 23 can be an electric push rod, and the movement of the moving part 231 along the first direction is achieved through the telescopic movement of the electric push rod. Another way is to use a slider mechanism driven by a stepper motor, and achieve precise movement of the moving part 231 through precise control of the stepper motor. In addition, a hydraulic cylinder or a pneumatic cylinder can also be used as the power member 23, and the moving part 231 can be driven to move by hydraulic or pneumatic means.
[0048] The present invention sets the balancing member 22 as the power member 23, and adopts a method of installing three of the power members 23 on the water base 21, so as to control the three power members 23 in real time to determine a plane, so that the electrophoresis tank 131 can achieve dynamic level adjustment during the electrophoresis process. Compared with the prior art, the advantage of the present invention is that it can more accurately control the level of the electrophoresis tank 131, thereby ensuring the uniform distribution of the electrophoresis liquid, thereby improving the effect of electrophoresis separation. At the same time, by adopting different types of the power members 23, the appropriate type of the power member 23 can be selected according to the specific experimental requirements, thereby improving the flexibility and adaptability of the system.
[0049] In some embodiments of the present invention, the end of the balancing member 22 away from the water base 21 is fixed to the connecting portion 111 by means of a ball bearing, and the end of the moving portion 231 away from the water base 21 is fixed to the connecting portion 111 by means of a ball bearing, and the device body 1 can move relative to the horizontal mechanism 2. The connection method of fixing with a ball bearing makes the device body 1 movable relative to the horizontal mechanism 2, ensuring that the device body 1 can be dynamically adjusted horizontally during the electrophoresis process.
[0050] For example, the end of the connecting part 111 away from the device body 1 can be set as a spherical structure, and the ends of the balancing member 22 and the power member 23 close to the device body 1 can be set as a groove structure that matches the connecting part 111; for another example, the ends of the balancing member 22 and the power member 23 close to the device body 1 can also be set as a spherical structure, and the end of the connecting part 111 away from the device body 1 can be set as a groove structure that matches the balancing member 22 and the power member 23. Through the mutual cooperation of the balancing member 22 and the moving part 231, the problem of horizontal adjustment of the electrophoresis tank 131 during electrophoresis is solved, thereby ensuring that the electrophoresis liquid is evenly distributed in the electrophoresis tank 131, and improving the effect of electrophoresis separation.
[0051] In addition, the material selection of the balancing member 22 and the moving part 231 can also be adjusted according to actual needs. For example, corrosion-resistant metal materials or high-strength composite materials can be selected to adapt to different experimental environments.
[0052] Thus, the present invention realizes the dynamic adjustment of the level of the device body 1 during the electrophoresis process through the connection mode of the balance member 22 and the moving part 231, overcomes the problem that the traditional electrophoresis device 100 cannot maintain the level during the electrophoresis process, ensures the uniform distribution of the electrophoresis liquid in the electrophoresis tank 131, and improves the effect of electrophoresis separation. Compared with the prior art, the technical solution of the present invention has higher accuracy and stability, and can adapt to the needs of different experimental environments.
[0053] In some embodiments of the present invention, the moving part 231 is configured as a push rod structure, and the output end of the power member 23 is connected to the moving part 231 and drives the moving part 231 to move along the first direction. By configuring the moving part 231 as a push rod structure, the cooperation of the push rod structure and the power member 23 can dynamically adjust the position of the device body 1 during the experiment, and keep the device body 1 level, thereby solving the problem that the electrophoresis device 100 cannot keep the device body 1 level during the experiment.
[0054] Specifically, the combined design of the push rod structure and the power member 23 can effectively drive the device body 1 to move in a specific direction, ensuring that the device body 1 always remains in a horizontal state during the experiment, thereby improving the accuracy and reliability of the electrophoresis experiment.
[0055] The push rod structure and the power member 23 can be combined in various forms, such as a hydraulic push rod, a pneumatic push rod or an electric push rod. The power member 23 can be a stepper motor, a servo motor or other drive device that can accurately control the movement. The push rod structure can be finely adjusted as needed during the experiment by the drive of the power member 23, so as to maintain the level of the electrophoresis tank 131. In addition, the combination of the push rod structure and the power member 23 can be programmed and adjusted by a control system to adapt to different experimental conditions and requirements.
[0056] The present invention combines the push rod structure with the power member 23, so that the electrophoresis device 100 can dynamically adjust the position of the electrophoresis tank 131 during the experiment to keep it horizontal. This design effectively solves the problem that the traditional electrophoresis device 100 cannot keep the electrophoresis tank 131 horizontal during the experiment, ensures the uniform distribution of the electrophoresis liquid, and improves the accuracy and reliability of the electrophoresis experiment. Compared with the prior art, the electrophoresis device 100 of the present invention has higher accuracy and stability, and can meet the needs of different experimental environments.
[0057] In some embodiments of the present invention, Figure 1 As shown, the device body 1 includes the first main body 11 and the tank body 13, the first main body 11 is formed with the mounting groove 112 that matches the tank body 13, the tank body 13 is installed in the mounting groove 112, and the tank body 13 is formed with the electrophoresis tank 131, and the electrophoresis tank 131 is used to accommodate samples. The sample can be firmly placed in the electrophoresis tank 131 to ensure the stability and reliability of the sample during the electrophoresis experiment. The device body 1 is composed of the first main body 11 and the tank body 13, the first main body 11 is provided with the mounting groove 112, the tank body 13 is installed in the mounting groove 112, and the tank body 13 is provided with the electrophoresis tank 131 for placing the sample.
[0058] Specifically, the cooperation between the mounting groove 112 of the first main body 11 and the tank body 13 enables the tank body 13 to be firmly mounted on the first main body 11 and is not easily moved or tilted. The setting of the electrophoresis tank 131 ensures that the sample can be stably placed in the electrophoresis tank 131 and the position of the sample will not be changed due to external factors. As a preferred embodiment, the size and shape of the electrophoresis tank 131 can be adjusted according to different types of samples to meet different experimental requirements.
[0059] Therefore, the present invention solves the problem of accommodating and fixing the sample in the electrophoresis tank 131 by providing the mounting groove 112 and the electrophoresis tank 131 on the device body 1. Compared with the prior art, the design of the present invention can better maintain the stability of the sample, avoid experimental errors caused by unstable position of the sample during the electrophoresis process, and improve the reliability and accuracy of the experimental results.
[0060] In some embodiments of the present invention, Figure 1 As shown, the device body 1 also includes a second main body part 12, which is installed on the first main body part 11 and fixes the tank body 13 on the first main body part 11. The second main body part 12 is formed with a through hole 121 that is consistent with the opening of the electrophoresis tank 131, and the sample passes through the through hole 121 into the electrophoresis tank 131.
[0061] The second main body 12 is mounted on the first main body 11 and the tank body 13 is fixed on the first main body 11, so that the tank body 13 can be ensured to remain stable during the electrophoresis process. The through hole 121 formed on the second main body 12 is consistent with the opening of the electrophoresis tank 131, ensuring that the sample can smoothly pass through the through hole 121 into the electrophoresis tank 131, thereby achieving effective transmission and fixation of the sample. These technical features work together to solve the problem of how to ensure that the sample can pass through the through hole 121 into the electrophoresis tank 131 and be fixed on the first main body 11 during the electrophoresis process.
[0062] The second main body 12 can be mounted on the first main body 11 in a variety of ways, such as by screws, buckles, etc. The size and shape of the through hole 121 should match the opening of the electrophoresis tank 131 to ensure that the sample can pass smoothly. Furthermore, the edge of the through hole 121 can be smoothed to prevent the sample from being damaged when passing through.
[0063] The technical solution of the present invention can better maintain the stability and transmission efficiency of the sample during the electrophoresis process, and improve the accuracy and reliability of the electrophoresis experiment. Therefore, the present invention has significant technical advantages in ensuring sample transmission and fixation.
[0064] In some embodiments of the present invention, Figure 1 As shown, the device body 1 further includes the temperature detection member 14, which is mounted on the first main body 11 and tests the temperature in the electrophoresis tank 131. By providing the temperature detection member 14, the temperature in the electrophoresis tank 131 can be effectively detected, thereby achieving real-time monitoring and adjustment of the temperature of the electrophoresis device 100, solving the problem of difficult temperature control during the electrophoresis process.
[0065] The temperature detection element 14 can be implemented in a variety of ways, for example, common temperature detection elements such as thermocouples, thermistors or infrared temperature sensors can be used. When the temperature detection element 14 is installed on the first main body 11, it can be installed by mechanical fixing, bonding or embedding to ensure that it can stably and accurately detect the temperature in the electrophoresis tank 131. Furthermore, the temperature detection element 14 can be connected to a temperature control system, which can automatically adjust the heating or cooling device of the electrophoresis device 100 according to the detected temperature to keep the temperature in the electrophoresis tank 131 within a set range.
[0066] By adding the temperature detection element 14 to the device body 1, real-time detection and control of the temperature in the electrophoresis tank 131 is achieved. This technical solution effectively solves the problem of temperature being difficult to control during electrophoresis, thereby improving the stability and accuracy of the electrophoresis experiment. Compared with the prior art, the electrophoresis device 100 provided by the present invention can not only maintain the level of the electrophoresis liquid, but also achieve constant temperature control, meeting the needs of different experimental environments.
[0067] In some embodiments of the present invention, Figure 1 As shown, the constant temperature mechanism 3 includes the refrigeration element 31 , which is installed on the first main body 11 at a side away from the notch of the installation groove 112 , and the refrigeration element 31 is arranged close to the installation groove 112 .
[0068] The refrigeration element 31 in the constant temperature mechanism 3 can maintain a constant temperature during the electrophoresis process, so as to prevent the electrophoresis liquid temperature from being too high and causing adverse effects on the separation and analysis of protein and nucleic acid molecules. The refrigeration element 31 is installed on the first main body 11 on a side away from the notch of the installation slot 112, and the refrigeration element 31 is arranged close to the installation slot 112, ensuring that the temperature in the electrophoresis tank 131 can be accurately controlled, thereby improving the accuracy and efficiency of electrophoresis separation.
[0069] The refrigeration element 31 may be a semiconductor refrigeration sheet or other suitable refrigeration equipment, which is driven by electric current to produce a cooling effect. A heat-conducting material may be arranged between the refrigeration element 31 and the mounting groove 112 to improve the cooling efficiency, or the mounting groove 112 is arranged in direct contact with the refrigeration element 31, or a through hole (not shown) is arranged at the bottom of the mounting groove 112 near the refrigeration element 31, and the refrigeration element 31 is installed in the through hole and in direct contact with the slot body 13, thereby improving the cooling efficiency.
[0070] Furthermore, the refrigeration element 31 can be connected to a temperature control system, and the temperature in the electrophoresis tank 131 can be monitored in real time through a temperature sensor, and the working state of the refrigeration element 31 can be automatically adjusted according to the detected temperature change to keep the temperature in the electrophoresis tank 131 constant. In addition, the refrigeration element 31 can also be used in conjunction with a heat dissipation system to dissipate excess heat through a heat sink or a fan to ensure a stable cooling effect.
[0071] The present invention can effectively control the temperature of the electrophoresis tank 131 by providing the cooling element 31 in the electrophoresis device 100 and installing it on the first main body 11 near the mounting groove 112, thereby solving the problem of excessive temperature during the electrophoresis process. Compared with the prior art, the technical solution of the present invention can improve the accuracy and efficiency of electrophoresis separation, and is suitable for protein and nucleic acid separation analysis in various biomedical research and clinical medicine fields.
[0072] In some embodiments of the present invention, Figure 1 As shown, the constant temperature mechanism 3 includes the first heat dissipation member 32 and the second heat dissipation member 33 . The first heat dissipation member 32 is installed on the refrigeration member 31 and is arranged away from the first main body 11 . The second heat dissipation member 33 is installed on the first heat dissipation member 32 and is arranged away from the refrigeration member 31 .
[0073] The first heat sink 32 and the second heat sink 33 cooperate with each other to effectively dissipate heat, thereby solving the problem that the electrophoresis device 100 cannot maintain a constant temperature during the electrophoresis process. Through this design, the electrophoresis device 100 can maintain a constant temperature during the electrophoresis process, avoiding the influence of temperature fluctuations on the electrophoresis effect, thereby improving the accuracy and stability of electrophoretic separation.
[0074] The first heat sink 32 and the second heat sink 33 can be implemented in a variety of ways. For example, the first heat sink 32 can be made of aluminum alloy material, which has good thermal conductivity and lightweight characteristics. The second heat sink 33 can be made of copper material, which has better thermal conductivity than aluminum alloy and can conduct heat away faster. Furthermore, the first heat sink 32 and the second heat sink 33 can be fixed between the refrigeration element 31 and each other by mechanical connection methods such as screws or snaps. In addition, thermal conductive silicone can be added between the first heat sink 32 and the second heat sink 33 to improve heat dissipation efficiency.
[0075] Specifically, the first heat sink 32 can be configured as a heat sink block, and the second heat sink 33 can be configured as a heat sink fan. The heat sink block and the heat sink fan cooperate to further improve the heat dissipation efficiency, and cooperate with the refrigeration element 31 to achieve constant temperature control of the electrophoresis process.
[0076] The present invention can effectively conduct the heat generated during the electrophoresis process through the heat sink by installing the first heat sink 32 on the refrigeration element 31 and installing the second heat sink 33 on the first heat sink 32, thereby maintaining a constant temperature. This design avoids the influence of temperature fluctuations on the electrophoresis effect, improves the accuracy and stability of electrophoretic separation, and has significant advantages over the prior art.
[0077] It should be understood that the above specific embodiments of the present invention are only used to illustrate or explain the principles of the present invention, and do not constitute a limitation of the present invention. Therefore, any modifications, equivalent substitutions, improvements, etc. made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. In addition, the appended claims of the present invention are intended to cover all changes and modifications that fall within the scope and boundaries of the appended claims, or the equivalent forms of such scope and boundaries.
Claims
1. A constant temperature electrophoresis device, characterized in that: include: A device body, wherein a connecting portion is provided on the device body, and the connecting portion is provided at a circumferential edge of the device body; A horizontal mechanism, the horizontal mechanism is connected to the connecting portion, the horizontal mechanism comprises a base, two power members and a balancing member, the two power members and the balancing member are mounted on the base, and the balancing member and the two power members are not on the same straight line; A constant temperature mechanism is installed on the device body.
2. The constant temperature electrophoresis device according to claim 1, characterized in that: The balancing member is configured as a rod extending along a first direction and vertically mounted on the base. The power member includes a moving part, and the moving part moves along the first direction.
3. The constant temperature electrophoresis device according to claim 1, characterized in that: The balancing member is configured as a power member, three of the power members are mounted on the base, and the power member includes a moving part, and the moving part moves along a first direction.
4. The constant temperature electrophoresis device according to claim 2 or 3, characterized in that: One end of the balancing member away from the base is fixed to the connecting part via a ball bearing, and one end of the moving part away from the base is fixed to the connecting part via a ball bearing, and the device body can move relative to the horizontal mechanism.
5. The constant temperature electrophoresis device according to claim 1, characterized in that: The moving part is configured as a push rod structure, and the output end of the power member is connected to the moving part and drives the moving part to move along a first direction.
6. The constant temperature electrophoresis device according to claim 1, characterized in that: The device body comprises: a first main body part and a slot body, the first main body part is formed with a mounting slot matched with the slot body, the slot body is installed in the mounting slot, the slot body is formed with an electrophoresis slot, and the electrophoresis slot is used to accommodate samples.
7. The constant temperature electrophoresis device according to claim 6, characterized in that: The device body also includes a second main body part, which is installed on the first main body part and fixes the tank body on the first main body part. A through hole consistent with the opening of the electrophoresis tank is formed on the second main body part, and the sample enters the electrophoresis tank through the through hole.
8. The constant temperature electrophoresis device according to claim 7, characterized in that: The device body also includes a temperature detection component, which is installed on the first main body and tests the temperature in the electrophoresis tank.
9. The constant temperature electrophoresis device according to claim 1, characterized in that: The constant temperature mechanism comprises: a refrigeration component, which is installed on the first main body at a side away from the notch of the installation slot, and the refrigeration component is arranged close to the installation slot.
10. The constant temperature electrophoresis device according to claim 9, characterized in that: The constant temperature mechanism includes a first heat dissipation member and a second heat dissipation member. The first heat dissipation member is mounted on the refrigeration member and is disposed away from the first main body. The second heat dissipation member is mounted on the first heat dissipation member and is disposed away from the refrigeration member.
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