Sample introduction device

Abstract

The invention relates to a sample introduction device, the sample introduction device comprises a sample introduction mechanism and a sampling mechanism, the sample introduction mechanism comprises a first mounting seat, a second mounting seat, a first driving part and a second driving part, the first mounting seat is used for placing a single sample tube, and the first driving part is connected with the first mounting seat and is used for driving the first mounting seat to move back and forth along a y direction; the second mounting seat is used for placing a sample disc integrated with a plurality of sample tubes, and the second driving part is connected with the first mounting seat and is used for driving the second mounting seat to move forwards and backwards along the y direction. The sampling mechanism is provided with a sampler capable of moving left and right in the x direction and moving up and down in the z direction, and the sampler can move towards the first mounting seat and is matched with the sample tube for sampling, so that the sampling device is in a single-tube sampling mode; or the sampler can move towards the second mounting seat and is matched with the sample disc for sampling, so that the sampling device is in a sample disc sampling mode.

Description

Technical Field

[0001] The present application relates to the technical field of detection auxiliary equipment, and in particular to a sample injection device. Background Art

[0002] LC-MS (Liquid Chromatograph Mass Spectrometer) is a detection method that combines the efficient separation ability of liquid chromatography with the precise material structure and mass analysis ability of mass spectrometry. It is known for its excellent selectivity, specificity and sensitivity. LC-MS not only shows its unique advantages in the field of clinical testing, but also plays an important role in establishing reference standards for clinical testing projects. With the continuous improvement of the ease of use and automation level of the technology, LC-MS is gradually becoming an indispensable part of clinical testing technology.

[0003] In order to meet the needs of large-scale sample testing and reduce the workload of operators, common sampling devices drive the sample plate to move through a sampling mechanism, and the sampling mechanism drives the sampler to move toward the sample plate to complete the sampling process. However, the above sampling mode is relatively simple and cannot meet the sampling needs in different scenarios. Summary of the invention

[0004] Based on this, it is necessary to provide a sampling device, which includes a sampling mechanism and a sampling mechanism. The sampling mechanism includes a first mounting seat, a second mounting seat, a first driving member and a second driving member. The first mounting seat is used to place a single sample tube. The first driving member is connected to the first mounting seat and is used to drive the first mounting seat to move forward and backward along y. The second mounting seat is used to place a sample tray with multiple sample tubes integrated. The second driving member is connected to the first mounting seat and is used to drive the second mounting seat to move forward and backward along y. The sampling mechanism is provided with a sampler that can move left and right along x and move up and down along z, and the sampler can move toward the first mounting seat and cooperate with the sample tube to sample, so that the sampling device is in a single tube sampling mode; or the sampler can move toward the second mounting seat and cooperate with the sample tray to sample, so that the sampling device is in a sample tray sampling mode.

[0005] In one embodiment, the first driving member includes a transmission rod, and a first conveyor belt and a first motor respectively mounted on the transmission rod. One end of the transmission rod is arranged close to the sampling mechanism, and the other end is used to connect the pre-processing device. The first mounting base is fixedly connected to the first conveyor belt, and the first motor drives the first conveyor belt to move along the y direction.

[0006] In one embodiment, the first mounting seat is provided with an assembly hole for placing a single sample tube, and the second mounting seat is provided with an assembly groove for placing a sample tray integrated with a plurality of sample tubes.

[0007] In one embodiment, the sample introduction mechanism further includes a support, the second driving member includes a second conveyor belt mounted on the support and a second motor, the second mounting base is fixedly connected to the second conveyor belt, and the second motor drives the second conveyor belt to move along the y direction.

[0008] In one embodiment, the support has a receiving groove, one end of the transmission rod is received in the receiving groove, and the other end extends out of the receiving groove and is used to connect to the pre-processing device.

[0009] In one embodiment, the first mounting seat and the second mounting seat are arranged vertically along the z direction on the support.

[0010] In one embodiment, the second driving member also includes a second slider and a second slide rail that slide together along the y direction. The second conveyor belt and the second slide rail are respectively installed on the outer wall of the support. The second mounting seat is fixedly connected to the second slider and is located at the opening of the accommodating groove.

[0011] In one embodiment, the support is further provided with a guide groove extending along the y direction, the guide groove and the second slider are respectively located on both sides of the second mounting seat along the x direction, and the second mounting seat is provided with a roller, which is rotatably mounted in the guide groove.

[0012] In one embodiment, the first driving member further includes a first slider and a first slide rail that are slidably matched along the y-direction, the first slide rail is fixedly mounted on the transmission rod, and the first mounting seat is fixedly connected to the first slider.

[0013] In one embodiment, the sampling mechanism includes a bracket and a plurality of sampling units mounted on the bracket, the number of samplers is configured to be multiple and arranged one-to-one with the sampling units; each sampling unit includes a third driving member and a fourth driving member, the fourth driving member is movably connected to the third driving member along the x-direction, the fourth driving member is connected to the sampler, and drives the sampler to move up and down along the z-axis.

[0014] Compared with the prior art, the sampling device provided by the present application can realize two injection modes by cooperating with the sampling mechanism and the injection mechanism. One is the single tube injection mode, and the other is the sample tray injection mode. In addition, the first driving member independently drives the first mounting seat to move, and the second driving member independently drives the second mounting seat to move, so that when one of the first driving member and the second driving member is damaged, the other can still drive the sample to move through the corresponding first mounting seat or the second mounting seat, thereby cooperating with the sampling mechanism to complete the sampling process. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the conventional technology, the drawings required for use in the embodiments or the conventional technology descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0016] Figure 1 An axonometric diagram of a sample injection device in one of the embodiments provided in the present application; Figure 2 for Figure 1 An enlarged schematic diagram at A; Figure 3 A top view of a sample injection device in one of the embodiments provided in the present application; Figure 4 Axonometric view of the sample feeding mechanism in one of the embodiments provided in this application Figure 1 ; Figure 5 Axonometric view of the sample feeding mechanism in one of the embodiments provided in this application Figure 2 ; Figure 6 A side view of a sample injection mechanism in one of the embodiments provided in the present application; Figure 7 A cross-sectional view of a sample injection mechanism in one of the embodiments provided in the present application.

[0017] Figure numerals: 100, injection device; 10, injection mechanism; 11, first drive member; 111, transmission rod; 111a, assembly chamber; 112, first conveyor belt; 113, first motor; 114, first slider; 115, first slide rail; 12, second drive member; 121, second conveyor belt; 122, second motor; 123, second slide rail; 124, second slider; 13, first mounting seat; 131, assembly hole; 14, second mounting seat; 141, assembly groove; 142, roller; 15, support; 151, accommodating groove; 152, guide groove; 20, sampling mechanism; 21, sampler; 22, sampling unit; 221, third drive member; 222, fourth drive member; 23, bracket; 30, base; 200, sample tray; 210, sample tube. DETAILED DESCRIPTION

[0018] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0019] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it may be directly on the other component or there may also be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of this application are for illustrative purposes only and do not represent the only implementation method.

[0020] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of this application, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0021] In the present application, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first feature is directly in contact with the second feature, or the first feature and the second feature are indirectly in contact through an intermediate medium. Moreover, a first feature being “above”, “above” or “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below” or “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0022] Unless otherwise defined, all technical and scientific terms used in the specification of this application have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" used in the specification of this application includes any and all combinations of one or more related listed items.

[0023] See also Figures 1 to 5The present application provides a sample injection device 100, which includes a base 30 and a sample injection mechanism 10 and a sampling mechanism 20 respectively mounted on the base 30. The sample injection mechanism 10 includes a first mounting seat 13, a second mounting seat 14, a first driving member 11 and a second driving member 12. The first mounting seat 13 is used to place a single sample tube 210. The first driving member 11 is connected to the first mounting seat 13 and is used to drive the first mounting seat 13 to move forward and backward along y. The second mounting seat 14 is used to place a sample tray 200 with multiple sample tubes 210 integrated therein. The second driving member 12 is connected to the first mounting seat 13 and is used to drive the second mounting seat 14 to move forward and backward along y. The sampling mechanism 20 is provided with a sampler 21 which can move left and right along the x direction and up and down along the z direction, and the sampler 21 can move toward the first mounting seat 13 and cooperate with the sample tube 210 to take samples, so that the sampling device is in a single tube sampling mode; or the sampler 21 can move toward the second mounting seat 14 and cooperate with the sample tray 200 to take samples, so that the sampling device is in a sample tray sampling mode.

[0024] In the present application, the sampling mechanism 20 cooperates with the injection mechanism 10 to realize two injection modes. One is a single tube injection mode, and the other is a sample tray injection mode. In addition, the first driving member 11 independently drives the first mounting seat 13 to move, and the second driving member 12 independently drives the second mounting seat 14 to move, so that when one of the first driving member 11 and the second driving member 12 is damaged, the other can still drive the sample to move through the corresponding first mounting seat 13 or second mounting seat 14, thereby cooperating with the sampling mechanism 20 to complete the sampling process.

[0025] Specifically, when the sampling device 100 is in the single tube sampling mode, the first driving member 11 drives the first mounting seat 13 to move forward and backward along the y direction, so that the single sample tube 210 on the first mounting seat 13 moves to be flush with the sampler 21 in the x direction and is located below the sampler 21 in the z direction, and then the sampling mechanism 20 drives the sampler 21 to move along the x direction and the z direction, so that the sampler 21 is inserted into the single sample tube 210 for sampling. When the sampling device 100 is in the sample tray sampling mode, the second driving member 12 drives the second mounting seat 14 to move forward and backward along the y direction, so that the sample tray 200 moves to a certain sample tube 210 thereon, so that it is flush with the sampler 21 in the x direction and is located below the sampler 21 in the z direction, and then the sampling mechanism 20 drives the sampler 21 to move along the x direction and the z direction, so that the sampler 21 is inserted into the sample tube 210 for sampling. Then the second driving member 12 drives the second mounting seat 14 to move forward and backward along the y direction again, so that the sample tray 200 moves to another sample tube 210 thereon so that it is flush with the sampler 21 in the x direction and is located below the sampler 21 in the z direction. Then the sampling mechanism 20 drives the sampler 21 to move along the x and z directions so that the sampler 21 is inserted into this sample tube 210 for sampling. This is repeated until the sampler 21 cooperates with all the sample tubes 210 on the sample tray 200 for sampling.

[0026] Furthermore, if Figure 4 and Figure 5 As shown, the first mounting seat 13 is provided with an assembly hole 131, and the assembly hole 131 is used to place a single sample tube 210. The second mounting seat 14 is provided with an assembly groove 141, and the assembly groove 141 is used to place a sample tray 200 integrated with multiple sample tubes 210. Optionally, the sample tray 200 is configured as a common 96-well sample tray, or other forms of sample trays commonly used in the field of chromatography.

[0027] like Figure 4 As shown, the first driving member 11 includes a transmission rod 111, and a first conveyor belt 112 and a first motor 113 respectively mounted on the transmission rod 111. One end of the transmission rod 111 is arranged close to the sampling mechanism 20, and the other end is used to connect the pre-processing device. The first mounting seat 13 is fixedly connected to the first conveyor belt 112, and the first motor 113 drives the first conveyor belt 112 to move along the y direction. In this way, after the pre-processing step is completed by the pre-processing device, the single sample tube 210 can be transported to the sampling mechanism 20 through the first mounting seat 13 on the first conveyor belt 112, thereby realizing the automatic transfer of the single sample tube 210 from the pre-processing device to the sampling device.

[0028] Specifically, Figure 7As shown, the first conveyor belt 112 includes two rollers arranged along the y direction and a belt body sleeved outside the two rollers, the first motor 113 is connected to one of the rollers in a transmission manner, and the first mounting seat 13 is fixedly connected to the belt body. The transmission rod 111 has an assembly cavity 111a, and the first conveyor belt 112 is installed in the assembly cavity 111a.

[0029] Furthermore, the first driving member 11 also includes a first slider 114 and a first slide rail 115 that slide in y-direction, the first slide rail 115 is fixedly mounted on the transmission rod 111, and the first mounting seat 13 is fixedly connected to the first slider 114. The first slider 114 and the first slide rail 115 guide the first mounting seat 13, so that the first mounting seat can move more smoothly along the y-direction. Among them, the first slide rail 115 and the first slider 114 are installed in the assembly cavity 111a, and at least part of the first mounting seat 13 extends from the side of the transmission rod 111 into the assembly cavity 111a and connects to the first slider 114. Optionally, the first slider 114 and the first slide rail 115 are assembled to form a ball linear guide.

[0030] The injection mechanism 10 also includes a support 15, the second driving member 12 includes a second conveyor belt 121 and a second motor 122 installed on the support 15, the second mounting base 14 is fixedly connected to the second conveyor belt 121, and the second motor 122 drives the second conveyor belt 121 to move along the y direction.

[0031] Specifically, the second conveyor belt 121 includes two rollers arranged along the y direction and a belt body sleeved outside the two rollers, the first motor 113 is transmission-connected to one of the rollers, and the second mounting seat 14 is fixedly connected to the belt body.

[0032] like Figure 5 and Figure 6 As shown, the support 15 has a receiving groove 151, one end of the transmission rod 111 is received in the receiving groove 151, and the other end extends out of the receiving groove 151 and is used to connect to the pre-processing device. In this way, the first driving member 11 and the second driving member 12 are integrated in the support 15, making the injection mechanism 10 compact.

[0033] Furthermore, the first mounting seat 13 and the second mounting seat 14 are arranged up and down along the z direction on the support 15. That is, the first mounting seat 13 and the second mounting seat 14 are arranged in two layers on the support 15, so that the structure of the injection mechanism 10 is more compact, which is conducive to reducing the space occupied by the injection mechanism 10 and reducing the stroke of the sampler 21 moving left and right along the z direction. Specifically, the first mounting seat 13 can be above the second mounting seat 14 along the z direction, or the second mounting seat 14 can be above the first mounting seat 13 along the z direction.

[0034] In one embodiment, if Figure 5As shown, the second driving member 12 also includes a second slider 124 and a second slide rail 123 that slide along the y direction, the second conveyor belt 121 and the second slide rail 123 are respectively mounted on the outer side wall of the support 15, and the second mounting seat 14 is fixedly connected to the second slider 124 and is located at the opening of the receiving groove 151. It can be understood that the second slider 124 and the second slide rail 123 guide the second mounting seat 14, so that the second mounting seat 14 can move more smoothly along the y direction. In addition, the second conveyor belt 121 and the second slide rail 123 are respectively mounted on the outer side wall of the support, which can prevent the second conveyor belt 121 and the second slide rail 123 from interfering with the first driving member 11 in the receiving groove 151. In this embodiment, the second mounting seat 14 is located at the opening of the receiving groove 151, and the first mounting seat 13 is located in the receiving groove 151, that is, the second mounting seat 14 is located above the first mounting seat 13 along the z direction.

[0035] like Figure 5 and Figure 7 As shown, the support 15 is further provided with a guide groove 152 extending along the y direction, the guide groove 152 and the second slider 124 are respectively located on both sides of the second mounting seat 14 along the x direction, and the second mounting seat 14 is provided with a roller 142, which is rotatably mounted on the guide groove 152. The roller 142 cooperates with the guide groove 152 to guide the second mounting seat 14, so that the second mounting seat 14 can move forward and backward along the y direction more smoothly.

[0036] Please refer again Figure 1 and Figure 2 The sampling mechanism 20 includes a bracket 23 and a plurality of sampling units 22 mounted on the bracket 23. The number of samplers 21 is configured to be multiple and is arranged one-to-one with the sampling units 22; wherein each sampling unit 22 includes a third driving member 221 and a fourth driving member 222, the fourth driving member 222 is movably connected to the third driving member 221 along the x-direction, the fourth driving member 222 is connected to the sampler 21, and drives the sampler 21 to move up and down along the z-axis.

[0037] Thus, when the sampling device 100 works in the single-tube sampling mode, only one sampling unit 22 is needed to drive a corresponding sampler 21 to move; when the sampling device 100 works in the sample tray sampling mode, multiple sampling units 22 can simultaneously drive the corresponding samplers 21 to move, thereby improving the sampling efficiency.

[0038] Optionally, the third driving member 221 drives the fourth driving member 222 to move left and right along the x direction through the cooperation of a motor and a screw, and the fourth driving member 222 drives the corresponding sampler 21 to move up and down along the z direction through the cooperation of a motor and a screw.

[0039] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0040] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the scope of patent protection of the present application shall be subject to the attached claims.

Claims

1. A sample injection device, characterized in that: The sample injection device (100) comprises: A sample injection mechanism (10), the sample injection mechanism (10) comprising a first mounting seat (13), a second mounting seat (14), a first driving member (11) and a second driving member (12), the first mounting seat (13) being used to place a single sample tube (210), the first driving member (11) being connected to the first mounting seat (13) and being used to drive the first mounting seat (13) to move forward and backward along the y direction; the second mounting seat (14) being used to place a sample tray (200) on which a plurality of sample tubes (210) are integrated, the second driving member (12) being connected to the first mounting seat (13) and being used to drive the second mounting seat (14) to move forward and backward along the y direction; A sampling mechanism (20), wherein the sampling mechanism (20) is provided with a sampler (21) capable of moving left and right along the x direction and moving up and down along the z direction; Furthermore, the sampler (21) can move toward the first mounting seat (13) and cooperate with the sample tube (210) to take samples, so that the sampling device is in a single-tube sampling mode; or the sampler (21) can move toward the second mounting seat (14) and cooperate with the sample tray (200) to take samples, so that the sampling device is in a sample tray sampling mode.

2. The sample injection device according to claim 1, characterized in that: The first driving member (11) comprises a transmission rod (111), and a first conveyor belt (112) and a first motor (113) respectively mounted on the transmission rod (111); one end of the transmission rod (111) is arranged close to the sampling mechanism (20), and the other end is used for connecting to a pre-processing device; the first mounting seat (13) is fixedly connected to the first conveyor belt (112); and the first motor (113) drives the first conveyor belt (112) to move along the y direction.

3. The sample injection device according to claim 2, characterized in that: The first mounting seat (13) is provided with an assembly hole (131), the assembly hole (131) being used to place a single sample tube (210), and the second mounting seat (14) is provided with an assembly groove (141), the assembly groove (141) being used to place a sample tray (200) integrated with a plurality of sample tubes (210).

4. The sample injection device according to claim 2, characterized in that: The sample introduction mechanism (10) further comprises a support (15); the second driving member (12) comprises a second conveyor belt (121) and a second motor (122) mounted on the support (15); the second mounting base (14) is fixedly connected to the second conveyor belt (121); and the second motor (122) drives the second conveyor belt (121) to move along the y direction.

5. The sample injection device according to claim 4, characterized in that: The support (15) has a receiving groove (151), one end of the transmission rod (111) is received in the receiving groove (151), and the other end extends out of the receiving groove (151) and is used to connect to a pre-processing device.

6. The sample injection device according to claim 5, characterized in that: The first mounting seat (13) and the second mounting seat (14) are arranged vertically along the z direction on the support (15).

7. The sample injection device according to claim 5, characterized in that: The second driving member (12) further comprises a second slider (124) and a second slide rail (123) which are slidably matched along the y direction; the second conveyor belt (121) and the second slide rail (123) are respectively mounted on the outer side wall of the support (15); the second mounting seat (14) is fixedly connected to the second slider (124) and is located at the opening of the accommodating groove (151).

8. The sample injection device according to claim 7, characterized in that: The support (15) is further provided with a guide groove (152) extending along the y direction, the guide groove (152) and the second sliding block (124) are respectively located on two sides of the second mounting seat (14) along the x direction, and the second mounting seat (14) is provided with a roller (142), and the roller (142) is rotatably mounted on the guide groove (152).

9. The sample injection device according to claim 2, characterized in that: The first driving member (11) further comprises a first sliding block (114) and a first sliding rail (115) which are slidably matched along the y direction, the first sliding rail (115) being fixedly mounted on the transmission rod (111), and the first mounting seat (13) being fixedly connected to the first sliding block (114).

10. The sample injection device according to claim 2, characterized in that: The sampling mechanism (20) comprises a bracket (23) and a plurality of sampling units (22) mounted on the bracket (23); the number of the samplers (21) is configured to be multiple and arranged in a one-to-one correspondence with the sampling units (22); Each of the sampling units comprises a third driving member (221) and a fourth driving member (222), wherein the fourth driving member (222) is movably connected to the third driving member (221) along the x-direction, and the fourth driving member (222) is connected to the sampler (21) and drives the sampler (21) to move up and down along the z-axis.

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