Compact full-automatic immunoassay analyzer

Abstract

The invention provides a compact full-automatic immunity analyzer which is provided with a reaction cup scheduling area and a sample reagent placing area, the reaction cup scheduling area is provided with a reaction cup loading module, an incubation module and a magnetic separation reading module, and a reaction cup gripper module is arranged above the reaction cup scheduling area. The sample reagent placing area is provided with a sample loading module and a reagent loading module, a pipetting module is arranged above the sample reagent placing area, and a distribution disc module is arranged between the reaction cup dispatching area and the sample reagent placing area; the reaction cup gripper module is used for dispatching reaction cups among the reaction cup loading module, the distribution disc module, the incubation module and the magnetic separation reading module, and the liquid transferring module is used for collecting samples in the sample loading module, collecting reagents in the reagent loading module and transferring liquid into the reaction cups in the distribution disc module. The compact full-automatic immunoassay analyzer is high in automation degree, large in test flux and small in overall size.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro diagnostic equipment, and more specifically to a compact fully automatic immunoassay analyzer. Background Art

[0002] In the field of in vitro diagnosis, immunoassay analyzers have the advantages of high precision, high sensitivity, and wide linear range. They combine chemiluminescence or bioluminescence systems with immune reactions and can be used to detect trace amounts of antigens or antibodies. When used in conjunction with corresponding test reagents, they can perform qualitative or quantitative detection of the analytes in samples such as serum, plasma, and urine.

[0003] At present, there are two development directions for immunoassay analyzers: one is large-scale, which increases the test throughput and has a high degree of automation, but the structure is relatively complex and occupies a large area; the other is miniaturization, which has a small test throughput, a low degree of automation and a low cost. There is no shortage of existing technologies for improving miniaturized immunoassay analyzers to increase their automation and test throughput, but with the increase of integrated functional modules, the size of the whole machine will also increase accordingly. In particular, when the test throughput increases, the overall area occupied by the equipment will increase significantly. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a compact fully automatic immunoassay analyzer with high automation and large test throughput but small size of the whole machine.

[0005] The technical solution of the present invention is to provide a compact fully automatic immunoassay analyzer, including a frame, a reaction cup scheduling area is arranged on one side of the frame, and a sample reagent placement area is arranged on the other side, the reaction cup scheduling area is provided with a reaction cup loading module, an incubation module, and a magnetic separation reading module, a reaction cup gripper module is arranged above the reaction cup scheduling area, a sample loading module and a reagent loading module are arranged in the sample reagent placement area, a pipetting module is arranged above the sample reagent placement area, and a distribution plate module is arranged between the reaction cup scheduling area and the sample reagent placement area; reaction cups arranged in a matrix for placing reaction cups are arranged on the reaction cup loading module and the incubation module. The sample loading module is provided with sample tube placement positions arranged in a matrix for placing sample tubes, the reagent loading module is provided with reagent tube placement positions arranged in a matrix for placing reagent tubes, the sample loading module is adjacent to the reagent loading module, the pipetting module is used to collect samples in the sample loading module, collect reagents in the reagent loading module, and transfer the collected samples or reagents to the reaction cups in the distribution tray module.

[0006] Compared with the prior art, the compact fully automatic immunoassay analyzer of the present invention has the following advantages: The cuvette gripper module in the cuvette dispatching area serves as a motion mechanism to uniformly dispatch the cuvettes, including taking out the cuvettes in the cuvette loading module and placing them in the designated position in the distribution tray module, transferring the cuvettes after sample and reagent loading in the distribution tray module to the incubation module for incubation, and transferring the cuvettes after incubation to the magnetic separation reading module for magnetic separation and detection reading; the cuvette loading module and the incubation module are both provided with cuvette placement positions for placing cuvettes arranged in a matrix, so that the cuvette loading module and the incubation module can be set to The rectangular structure facilitates the compact splicing of the reaction cup loading module and the incubation module. The reaction cup placement positions arranged in a matrix are not only conducive to improving the test throughput, but also convenient for positioning and grabbing the reaction cup gripper module. The magnetic separation reading module, the distribution plate module and the incubation module are arranged adjacent to each other, which can not only make the modules in the reaction cup scheduling area compact, but also make the movement range of the reaction cup gripper module as small as possible. The reaction cup gripper module itself is located above other modules in the reaction cup scheduling area, and basically does not occupy any area. All designs minimize the area occupied by the reaction cup scheduling area. The pipetting module in the sample reagent placement area serves as a motion mechanism, collects samples from the sample loading module and pipets them into the reaction cup of the distribution plate module, collects reagents from the reagent loading module and pipets them into the reaction cup of the distribution plate module, and completes the filling of samples and reagents; the sample loading module is provided with sample tube placement positions arranged in a matrix for placing sample test tubes, so that the main structure of the sample loading module can be set as a rectangular structure, and the reagent loading module is provided with reagent tube placement positions arranged in a matrix for placing reagent test tubes, so that the main structure of the reagent loading module can also be set as a rectangular structure, which is convenient for the sample loading module and the reagent loading module to be compactly spliced ​​together, the sample tube placement positions and reagent tube placement positions arranged in a matrix are not only conducive to improving the test throughput, but also convenient for the positioning of the pipetting module to collect samples or reagents, the pipetting module is arranged above the sample reagent placement area, and basically does not occupy an area, so that the area occupied by the sample reagent placement area is minimized; the distribution plate module is arranged between the reaction cup scheduling area and the sample reagent placement area, which also makes the action range of the pipetting module as small as possible; In summary, separating the reaction cup scheduling area from the sample reagent placement area is conducive to allowing the reaction cup gripper module and the pipetting module to move only within their respective areas, with a high degree of automation and a large test throughput. The overlapping areas of their activity ranges are small, and the overall structure is compact and small in size.

[0007] Preferably, the distribution plate module includes a distribution plate bracket, on which a turntable and a turntable motor are provided, on which a reaction cup loading hole for placing a reaction cup is provided, and the turntable motor is used to drive the turntable to rotate so that the reaction cup loading hole enters the reaction cup scheduling area or the sample reagent placement area. With this structure, when the reaction cup gripper module is to operate the reaction cup, the turntable can be rotated to the reaction cup loading hole to enter the reaction cup scheduling area, which is convenient for the reaction cup gripper module to operate; when the liquid transfer module is to transfer liquid into the reaction cup, the turntable can be rotated to the reaction cup loading hole to enter the sample reagent placement area, which is convenient for the liquid transfer module to operate; in this way, the overlapping range of activities of the reaction cup gripper module and the liquid transfer module is basically avoided, making the overall structure more compact.

[0008] Preferably, a reaction liquid mixing motor and a cover plate are provided on the distribution plate support. The reaction liquid mixing motor is located between the reaction cup scheduling area and the sample reagent placement area. The turntable motor is also used to drive the turntable to rotate so that the reaction cup loading hole is located directly above the reaction liquid mixing motor. The reaction liquid mixing motor is used to drive the reaction cup in the reaction cup loading hole to rise and fall repeatedly. The cover plate is located above the turntable and is used to limit the reaction cup in the reaction cup loading hole. With this structure, when the pipetting module completes the filling of samples and reagents into the reaction cup, the turntable can be rotated to directly above the reaction liquid mixing motor, and the liquid in the reaction cup can be shaken and mixed by the action of the mixing motor. At the same time, the cover plate limits the upper end of the reaction cup to prevent the reaction cup from moving upward and detaching from the mixing motor during the shaking process. The cover plate can only cover the area above the mixing motor, not cover other areas of the turntable, and does not affect the loading and filling of samples and reagents into the reaction cup.

[0009] Preferably, a reset sensor is provided on the distribution plate support, and the reset sensor is used to detect whether the reaction cup in the reaction cup loading hole is reset after lifting. With this structure, it is convenient to ensure that the reaction cup is reset after the reaction cup is shaken and mixed, and to prevent the reaction cup from shifting in the vertical direction to interfere with the subsequent rotation of the turntable.

[0010] Preferably, the cover plate is provided with a position-avoiding port and a filling hole, which are respectively located in the reaction cup scheduling area and the sample reagent placement area. When the turntable rotates to the reaction cup loading hole entering the reaction cup scheduling area, the position-avoiding port avoids the reaction cup loading hole; when the turntable rotates to the reaction cup loading hole entering the sample reagent placement area, the filling hole and the reaction cup loading hole are opposite to each other up and down. With this structure, the cover plate can always limit the reaction cup during the reaction cup rotating with the turntable, and can also prevent foreign matter from entering the reaction cup. At the same time, the position-avoiding port and the filling hole will not affect the loading and filling of samples and reagents in the reaction cup.

[0011] Preferably, a brush is provided on the distribution plate support, and the brush is located between the reaction cup scheduling area and the sample reagent placement area. When the turntable rotates to make the reaction cup loading hole enter the sample reagent placement area from the reaction cup scheduling area, the brush is used to contact the reaction cup in the reaction cup loading hole to eliminate the static electricity on the reaction cup. With this structure, the static electricity on the reaction cup is prevented from affecting the chemical reaction between the sample and the reagent.

[0012] Preferably, the reagent loading module includes a cabin, reagent tube placement positions arranged in a matrix for placing reagent test tubes are arranged in the cabin, an upper cabin plate is arranged on the upper side of the cabin, and reagent through holes corresponding to the reagent tube placement positions are arranged on the upper cabin plate; a refrigeration module is arranged on the lower side of the cabin, and the refrigeration module is used to adjust the temperature in the cabin. With this structure, the cabin and the refrigeration module are arranged to facilitate the provision of space and temperature required for storing reagents; the refrigeration module is arranged on the lower side of the cabin, which will not increase the floor space of the reagent loading module and is also conducive to rapid temperature adjustment of the reagents in the cabin; the upper cabin plate is arranged to avoid the space in the cabin from being completely exposed to the outside, reduce the entry of foreign matter, and reduce the loss rate of cold in the cabin. The upper cabin plate is provided with reagent through holes arranged in a matrix corresponding to the reagent tube placement positions, which is convenient for the pipetting module to locate and collect reagents.

[0013] Preferably, a refrigeration partition is provided in the cabin below the upper cabin plate, and a partition drive motor connected to the refrigeration partition is provided on the outside of the cabin, and the partition drive motor is used to drive the refrigeration partition to move to block the reagent through-hole. With this structure, the movement of the refrigeration partition can open the reagent through-hole where the pipetting module is located to the outside, which is convenient for the pipetting module to collect reagents, while the reagent through-hole where the pipetting module is not located is closed to the outside, so as to avoid a large number of through-holes affecting the refrigeration effect.

[0014] Preferably, a reagent mixing motor for shaking the cabin is also provided on the outside of the cabin. With this structure, the cabin can provide regular mixing of heterogeneous reagents.

[0015] Preferably, the magnetic separation reading module integrates a magnetic separation component and a reading component, wherein the magnetic separation component includes an acid filling module, a mixing module, a waste liquid extraction module, a waste liquid needle driving module, a waste liquid needle module, and a cleaning liquid filling module, and the reading component includes a shutter module, a photon counting module, and a shading mechanism. With this structure, the magnetic separation component and the reading component are integrated into the magnetic separation reading module, avoiding the need to separately set up a magnetic separation device and a reading device, further improving the compactness of the overall structure and reducing the overall footprint; the magnetic separation link and the reading link are centrally arranged to achieve three-stage magnetic separation of magnetic adsorption, waste liquid absorption, cleaning liquid addition, and mixing, and light is avoided through the shading mechanism to provide a dark environment for result detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1It is a schematic diagram of the overall structure of the compact fully automatic immunoassay analyzer of the present invention.

[0017] Figure 2 It is a top view of the compact fully automatic immunoassay analyzer of the present invention.

[0018] Figure 3 It is a structural schematic diagram of a reaction cup loading module of a compact fully automatic immunoassay analyzer of the present invention.

[0019] Figure 4 It is a structural schematic diagram of a reaction cup gripper module of a compact fully automatic immunoassay analyzer of the present invention.

[0020] Figure 5 It is a schematic structural diagram of the distribution plate module of the compact fully automatic immunoassay analyzer of the present invention.

[0021] Figure 6 It is a schematic structural diagram of a sample loading module of a compact fully automatic immunoassay analyzer of the present invention.

[0022] Figure 7 It is a schematic structural diagram of a reagent loading module of a compact fully automatic immunoassay analyzer of the present invention.

[0023] Figure 8 It is a schematic diagram of the structure of the liquid transfer module of the compact fully automatic immunoassay analyzer of the present invention.

[0024] Fig. 9 It is a schematic diagram of the structure of the magnetic separation reading module of the compact fully automatic immunoassay analyzer of the present invention.

[0025] Fig.10 It is a schematic diagram of the structure of the incubation module of the compact fully automatic immunoassay analyzer of the present invention.

[0026] As shown in the figure: 1. Reaction cup gripper module, 1-1. Y-axis mounting plate, 1-2. Drag chain support plate, 1-3. Reaction cup gripper, 1-4. X-axis mounting plate, 1-5. Lifting motor, 1-6. Y guide rail, 2. Magnetic separation reading module, 2-1. Acid filling module, 2-2. Waste liquid extraction module, 2-3. Photon counting module, 2-4. Mixing module, 2-5. Shutter module, 2-6. Waste liquid needle drive module, 2-7. Shading mechanism, 2-8. Cleaning liquid filling module, 2-9. Waste liquid needle module, 3. Incubation module, 3-1. Incubation block body, 3-2. Third bracket, 3-3. Heating belt, 4. Reaction cup loading module, 4-1. First slide rail, 4-2. Second slide rail, 4-3. Fourth bracket, 4-4. Bracket platform, 4-5. Tray, 5. Sample loading module, 5-1. Sample rack, 5-2. Sample rack sensor, 6. Pipetting module, 6-1. Z-axis motion mechanism, 6-2. Sixth bracket, 6-3. Pipetting needle, 6-4. Y-axis motion mechanism, 6-5. X-axis motion mechanism, 7. Distribution plate module, 7-1. Reset sensor, 7-2. Turntable, 7-21. Turntable motor, 7-22. Reaction cup loading hole, 7-3. Reaction liquid mixing motor, 7-4. Distribution plate bracket, 7-5. Brush, 7-6. Cover plate, 7-61. Filling hole, 7-62. Avoidance port, 8. Reagent loading module, 8-1. Cabin, 8-2. Refrigeration module, 8-3. Reagent mixing motor, 8-4. Refrigeration partition, 8-5. Reagent through hole, 8-6. Partition drive motor, 8-7. Pull-out mechanism, 9. Rack. DETAILED DESCRIPTION

[0027] In order to better understand the present application, a more detailed description of various aspects of the present application will be made with reference to the accompanying drawings. It should be understood that these detailed descriptions are only descriptions of exemplary embodiments of the present application, and do not limit the scope of the present application in any way. Throughout the specification, the same figure numerals refer to the same elements.

[0028] In the drawings, the thickness, size and shape of objects have been slightly exaggerated for ease of explanation. The drawings are only examples and are not drawn strictly to scale.

[0029] It should also be understood that the terms "comprises", "having", "includes", "comprising", when used in this specification, indicate the presence of the described features, integers, steps, operations, elements and / or components, but do not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components and / or combinations thereof. In addition, when a statement such as "...at least one" appears after a list of listed features, it modifies the entire listed features rather than modifying the individual elements in the list.

[0030] like Figure 1 and Figure 2As shown in , the compact fully automatic immunoassay analyzer of the present invention includes a frame 9, a reaction cup scheduling area is arranged on the left side of the frame 9, and a sample reagent placement area is arranged on the other side. The reaction cup scheduling area is provided with a reaction cup loading module 4, an incubation module 3, and a magnetic separation reading module 2. A reaction cup gripper module 1 is arranged above the reaction cup scheduling area, a sample loading module 5 and a reagent loading module 8 are arranged in the sample reagent placement area, and a pipetting module 6 is arranged above the sample reagent placement area. A distribution plate module 7 is arranged between the reaction cup scheduling area and the sample reagent placement area; the main bodies of the reaction cup loading module 4 and the incubation module 3 are both arranged in a rectangular structure, and one side of the reaction cup loading module 4 is close to one side of the incubation module 3, and the magnetic separation reading module 2, the distribution plate module 7 and the incubation module 3 form a triangular layout and are arranged adjacent to each other; the main bodies of the sample loading module 5 and the reagent loading module 8 are both arranged in a rectangular structure, and one side of the sample loading module 5 is also close to one side of the reagent loading module 8. Compared with the disc-shaped structure, the rectangular structure is more conducive to the close cooperation of the two modules and reduces space waste.

[0031] like Figure 3 As shown in , the cuvette loading module 4 includes a fourth bracket 4-3, a bracket platform 4-4 is arranged on the fourth bracket 4-3, a first slide rail 4-1 and a second slide rail 4-2 are arranged on the bracket platform 4-4, a tray 4-5 is arranged on each of the first slide rail 4-1 and the second slide rail 4-2, and a cuvette placement position for placing cuvettes arranged in a matrix is ​​arranged on the tray 4-5. In this embodiment, the left and right trays 4-5 are arranged into two channels, which can support the storage of a total of 180 cuvettes, and the test throughput is large. The two-channel setting can support online loading of cuvettes, that is, the cuvettes can be stored in one tray 4-5, and the cuvettes can be taken out in another tray 4-5 at the same time, without affecting the operation of the system.

[0032] like Fig.10 As shown in , the incubation module 3 includes a third bracket 3-2, on which an incubation block body 3-1 is arranged, and incubation block body 3-1 is provided with cuvette placement positions arranged in a matrix for placing cuvettes, and incubation block body 3-1 is also provided with a heating belt 3-3, and heating belt 3-3 is used to control the temperature in incubation block body 3-1. Incubation module 3 mainly realizes the constant temperature storage of cuvettes, and the reaction liquid in the cuvette needs to set a temperature, so the module includes a corresponding temperature control module, namely heating belt 3-3. In this embodiment, incubation module 3 can place a total of 60 cuvettes, and the test throughput is large.

[0033] like Fig. 9As shown in the figure, the magnetic separation reading module 2 integrates a magnetic separation component and a reading component. The magnetic separation component includes a magnetic separation seat for placing a reaction cup and an acid filling module 2-1, a mixing module 2-4, a waste liquid extraction module 2-2, a waste liquid needle driving module 2-6, a waste liquid needle module 2-9, a cleaning liquid filling module 2-8 and a magnetic adsorption module located above the magnetic separation seat. The reading component includes a shutter module 2-5, a photon counting module 2-3, and a shading mechanism 2-7.

[0034] The waste liquid extraction module 2-2 is used to remove the residual reagents in the reaction cup so that the magnetic separation process can be carried out continuously. The magnetic adsorption module is attached to or close to the reaction cup, and separates the corresponding components in the reagents through the principle of magnetic force. The cleaning liquid filling module 2-8 fills the reaction cup with cleaning liquid to clean the magnetic particles. The mixing module 2-4 includes a power structure that acts on the reaction cup by rotation or vibration, and completes the mixing of the internal reagents by shaking, rotating or vibrating the reaction cup. The waste liquid needle driving module 2-6 can drive the waste liquid needle module 2-9 to rise and fall, and accurately absorb the waste liquid in the reaction cup. The acid filling module 2-1 adds acid to the reaction conjugate in the reaction cup. The reaction cup that completes the magnetic separation is provided with a closed shading environment by the shading mechanism 2-7 to facilitate the process operation of optical detection, ensure light density, and the shutter module 2-5 assists the photon counting module 2-3 in detection and reading.

[0035] The magnetic separation component and the reading component are integrated into the magnetic separation reading module 2, avoiding the need to separately provide a magnetic separation device and a reading device, further improving the compactness of the overall structure and reducing the overall footprint of the machine.

[0036] like Figure 5 As shown in the figure, the distribution plate module 7 includes a distribution plate bracket 7-4, on which a turntable 7-2 and a turntable motor 7-21 are provided, and the turntable 7-2 is provided with a reaction cup loading hole 7-22 for placing a reaction cup, and the turntable motor 7-21 is used to drive the turntable 7-2 to rotate so that the reaction cup loading hole 7-22 enters the reaction cup scheduling area or the sample reagent placement area.

[0037] A brush 7-5 is provided on the distribution plate bracket 7-4. The brush 7-5 is located on the way where the reaction cup loading hole 7-22 switches from the reaction cup scheduling area to the sample reagent placement area. When the turntable 7-2 rotates to make the reaction cup loading hole 7-22 enter the sample reagent placement area from the reaction cup scheduling area, the brush 7-5 is used to contact the reaction cup in the reaction cup loading hole 7-22 to eliminate static electricity on the reaction cup.

[0038] A reaction liquid mixing motor 7-3 and a reset sensor 7-1 are provided on the distribution plate bracket 7-4. The reaction liquid mixing motor 7-3 is located on the way where the reaction cup loading hole 7-22 switches from the sample reagent placement area to the reaction cup scheduling area. The turntable motor 7-21 can drive the turntable 7-2 to rotate so that the reaction cup loading hole 7-22 is located directly above the reaction liquid mixing motor 7-3. The reaction liquid mixing motor 7-3 is used to drive the reaction cup in the reaction cup loading hole 7-22 to rise and fall repeatedly. The reset sensor 7-1 is used to detect whether the reaction cup in the reaction cup loading hole 7-22 is reset after rising and falling.

[0039] A cover plate 7-6 is provided above the turntable 7-2, and the cover plate 7-6 is used to limit the reaction cup in the reaction cup loading hole 7-22. The cover plate 7-6 is provided with a clearance port 7-62 and a filling hole 7-61, which are respectively located in the reaction cup scheduling area and the sample reagent placement area. When the turntable 7-2 rotates to the reaction cup loading hole 7-22 entering the reaction cup scheduling area, the clearance port 7-62 avoids the reaction cup loading hole 7-22; when the turntable 7-2 rotates to the reaction cup loading hole 7-22 entering the sample reagent placement area, the filling hole 7-61 is opposite to the reaction cup loading hole 7-22 up and down.

[0040] like Figure 4 As shown in, the reaction cup gripper module 1 includes a Y-direction mounting plate 1-1, a drag chain support plate 1-2 and a Y-direction guide rail 1-6 are arranged on the Y-direction mounting plate 1-1, a drag chain is arranged on the drag chain support plate 1-2, an X-direction mounting plate 1-4 is arranged on the Y-direction guide rail 1-6, a reaction cup gripper 1-3 and a lifting motor 1-5 are arranged on the X-direction mounting plate 1-4, and the drag chain is also connected to the X-direction mounting plate 1-4. The reaction cup gripper 1-3 and the lifting motor 1-5 can move along the Y direction on the Y-direction guide rail 1-6 with the X-direction mounting plate 1-4, and can also move along the X direction on the X-direction mounting plate 1-4. The lifting motor 1-5 can drive the reaction cup gripper 1-3 to rise and fall along the Z direction, and the drag chain support plate 1-2 can support the drag chain support and the wiring harness arrangement.

[0041] The reaction cup gripper module 1 serves as a motion mechanism in the reaction cup scheduling area, and can realize three-dimensional operation scheduling of the reaction cup, including taking out the reaction cup clamp in the reaction cup loading module 4 and placing it in the specified position in the distribution plate module 7, transferring the reaction cup after sample and reagent loading in the distribution plate module 7 to the incubation module 3 for incubation, and transferring the reaction cup after incubation to the magnetic separation reading module 2 for magnetic separation and detection reading.

[0042] like Figure 6As shown in , the sample loading module 5 is divided into three channels, which can realize the storage of three sample racks 5-1. The sample rack 5-1 is provided with a plurality of sample tube placement positions arranged in a line for placing sample test tubes. A sample rack sensor 5-2 is provided at the end of each sample rack 5-1, and the sample rack sensor 5-2 can realize the pick-up and placement detection of each channel. The multi-channel setting can support the system to realize online loading of samples.

[0043] like Figure 7 As shown in, the reagent loading module 8 includes a cabin 8-1, a pull-out mechanism 8-7 is arranged in the cabin 8-1, and reagent tube placement positions arranged in a matrix for placing reagent test tubes are arranged in the pull-out mechanism 8-7, and the pull-out mechanism 8-7 enters and exits the cabin 8-1 from the front side of the cabin 8-1; an upper cabin plate is arranged on the upper side of the cabin 8-1, and reagent through holes 8-5 corresponding to the reagent tube placement positions are arranged on the upper cabin plate; a refrigeration module 8-2 is arranged on the lower side of the cabin 8-1, and the refrigeration module 8-2 is used to adjust the temperature in the cabin 8-1; a refrigeration partition 8-4 is arranged below the upper cabin plate in the cabin 8-1, and a partition drive motor 8-6 connected to the refrigeration partition 8-4 is arranged on the rear side of the cabin 8-1, and the partition drive motor 8-6 is used to drive the refrigeration partition 8-4 to move to block the reagent through holes 8-5. The reagent loading module 8 is used to provide the temperature and space required for storing reagents. The refrigeration partition 8-4 can block the upper through holes under the action of the partition driving motor 8-6 to prevent a large number of through holes from affecting the refrigeration effect.

[0044] A reagent mixing motor 8-3 for shaking the cabin 8-1 is also provided on the rear side of the cabin 8-1. The reagent mixing motor 8-3 can achieve mixing of heterogeneous reagents in the module.

[0045] like Figure 8 As shown in , the pipetting module 6 includes a sixth bracket 6-2, on which an X-direction motion mechanism 6-5 is disposed, on which a Y-direction motion mechanism 6-4 is disposed, and on which a Z-direction motion mechanism 6-1 and a pipetting needle 6-3 are disposed. The pipetting needle 6-3 and the Z-direction motion mechanism 6-1 can move along the X-direction with the Y-direction motion mechanism 6-4 under the drive of the X-direction motion mechanism 6-5, and can move along the Y-direction under the drive of the Y-direction motion mechanism 6-4, and the Z-direction motion mechanism 6-1 can drive the pipetting needle 6-3 to rise and fall along the Z-direction.

[0046] The pipetting module 6 is a motion mechanism in the sample and reagent placement area. It collects samples from the sample loading module 5 and transfers them to the reaction cup of the distribution tray module 7. It collects reagents from the reagent loading module 8 and transfers them to the reaction cup of the distribution tray module 7 to complete the quantitative filling of samples and reagents. This module can realize three-dimensional movement. The pipetting needle 6-3 has functions such as liquid level detection and vertical collision prevention.

[0047] The working process of the compact fully automatic immunoassay analyzer of the present invention is as follows: the reaction cup gripper module 1 clamps the reaction cup in the reaction cup loading module 4 and places it in the reaction cup loading hole 7-22 located in the reaction cup scheduling area in the distribution plate module 7; then the distribution plate module 7 rotates to make the reaction cup loading hole 7-22 reach the sample reagent placement area, and the liquid transfer module 6 transfers liquid from the sample loading module 5 and the reagent loading module 8 to the reaction cup in turn, completing the filling of the sample and the reagent; the distribution plate module 7 rotates until the reaction cup loading hole 7-22 is located directly above the reaction liquid mixing motor 7-3, and the reaction cup is The liquid mixing motor 7-3 performs the mixing step; after the mixing is completed, the distribution plate module 7 rotates to the initial position, that is, the reaction cup loading hole 7-22 is located in the reaction cup scheduling area, and the reaction cup gripper module 1 transfers the reaction cup to the incubation module 3 for incubation; after the incubation is completed, the reaction cup gripper module 1 transfers the reaction cup to the magnetic separation reading module 2, and completes the three-stage magnetic separation action of "magnetic adsorption, waste liquid absorption, adding cleaning liquid, and mixing" in sequence. The object to be measured is adsorbed on the wall of the reaction cup under the action of the magnetic field, and the components not participating in the reaction are extracted, and finally the result detection is completed under the action of the photon counting module 2-3.

[0048] The above are only specific embodiments of the present invention and are not intended to limit the scope of implementation of the present invention. If the present invention is modified or replaced by equivalents without departing from the spirit and scope of the present invention, they should all be included in the protection scope of the claims of the present invention.

Claims

1. A compact fully automatic immunoassay analyzer, comprising a frame (9), characterized in that: A reaction cup scheduling area is arranged on one side of the rack (9), and a sample reagent placement area is arranged on the other side. The reaction cup scheduling area is provided with a reaction cup loading module (4), an incubation module (3), and a magnetic separation reading module (2). A reaction cup gripper module (1) is arranged above the reaction cup scheduling area. The sample reagent placement area is provided with a sample loading module (5) and a reagent loading module (8). A pipetting module (6) is arranged above the sample reagent placement area. A distribution plate module (7) is arranged between the reaction cup scheduling area and the sample reagent placement area. The reaction cup loading module (4) and the incubation module (3) are both provided with reaction cup placement positions for placing reaction cups arranged in a matrix, and the reaction cup loading module (4) is arranged adjacent to the incubation module (3). The magnetic separation reading module (2), the distribution plate module (7) and the incubation module (3) are arranged adjacent to each other, and the reaction cup gripper module (1) is used to dispatch the reaction cups between the reaction cup loading module (4), the distribution plate module (7), the incubation module (3) and the magnetic separation reading module (2); the sample loading module (5) is provided with sample tube placement positions arranged in a matrix for placing sample test tubes, and the reagent loading module (8) is provided with reagent tube placement positions arranged in a matrix for placing reagent test tubes. The sample loading module (5) is arranged adjacent to the reagent loading module (8), and the pipetting module (6) is used to collect samples in the sample loading module (5), collect reagents in the reagent loading module (8), and transfer the collected samples or reagents to the reaction cups in the distribution plate module (7).

2. The compact fully automatic immunoassay analyzer according to claim 1, characterized in that: The distribution plate module (7) comprises a distribution plate support (7-4), a turntable (7-2) and a turntable motor (7-21) are arranged on the distribution plate support (7-4), a reaction cup loading hole (7-22) for placing a reaction cup is arranged on the turntable (7-2), and the turntable motor (7-21) is used to drive the turntable (7-2) to rotate so that the reaction cup loading hole (7-22) enters the reaction cup scheduling area or the sample reagent placement area.

3. The compact fully automatic immunoassay analyzer according to claim 2, characterized in that: A reaction liquid mixing motor (7-3) and a cover plate (7-6) are arranged on the distribution plate bracket (7-4); the reaction liquid mixing motor (7-3) is located between the reaction cup scheduling area and the sample reagent placement area; the turntable motor (7-21) is also used to drive the turntable (7-2) to rotate so that the reaction cup loading hole (7-22) is located directly above the reaction liquid mixing motor (7-3); the reaction liquid mixing motor (7-3) is used to drive the reaction cup in the reaction cup loading hole (7-22) to rise and fall repeatedly; the cover plate (7-6) is located above the turntable (7-2) and is used to limit the reaction cup in the reaction cup loading hole (7-22).

4. The compact fully automatic immunoassay analyzer according to claim 3, characterized in that: A reset sensor (7-1) is arranged on the distribution plate support (7-4), and the reset sensor (7-1) is used to detect whether the reaction cup in the reaction cup loading hole (7-22) is reset after being lifted or lowered.

5. The compact fully automatic immunoassay analyzer according to claim 3, characterized in that: The cover plate (7-6) is provided with a avoidance opening (7-62) and a filling hole (7-61), the avoidance opening (7-62) and the filling hole (7-61) are respectively located in a reaction cup scheduling area and a sample reagent placement area; when the turntable (7-2) rotates to the reaction cup loading hole (7-22) and enters the reaction cup scheduling area, the avoidance opening (7-62) avoids the reaction cup loading hole (7-22); when the turntable (7-2) rotates to the reaction cup loading hole (7-22) and enters the sample reagent placement area, the filling hole (7-61) and the reaction cup loading hole (7-22) are opposite to each other up and down.

6. The compact fully automatic immunoassay analyzer according to claim 2, characterized in that: A brush (7-5) is arranged on the distribution plate support (7-4), and the brush (7-5) is located between the reaction cup scheduling area and the sample reagent placement area. When the turntable (7-2) rotates to make the reaction cup loading hole (7-22) enter the sample reagent placement area from the reaction cup scheduling area, the brush (7-5) is used to contact the reaction cup in the reaction cup loading hole (7-22) to eliminate static electricity on the reaction cup.

7. The compact fully automatic immunoassay analyzer according to claim 1, characterized in that: The reagent loading module (8) comprises a cabin (8-1), reagent tube placement positions for placing reagent test tubes arranged in a matrix are arranged in the cabin (8-1), an upper cabin plate is arranged on the upper side of the cabin (8-1), and reagent through holes (8-5) corresponding to the reagent tube placement positions are arranged on the upper cabin plate; a refrigeration module (8-2) is arranged on the lower side of the cabin (8-1), and the refrigeration module (8-2) is used to adjust the temperature in the cabin (8-1).

8. The compact fully automatic immunoassay analyzer according to claim 7, characterized in that: A refrigeration partition (8-4) is arranged below the upper cabin plate in the cabin body (8-1), and a partition drive motor (8-6) connected to the refrigeration partition (8-4) is arranged on the outer side of the cabin body (8-1). The partition drive motor (8-6) is used to drive the refrigeration partition (8-4) to move so as to block the reagent through hole (8-5).

9. The compact fully automatic immunoassay analyzer according to claim 7, characterized in that: A reagent mixing motor (8-3) for shaking the cabin (8-1) is also provided on the outside of the cabin (8-1).

10. The compact fully automatic immunoassay analyzer according to claim 1, characterized in that: The magnetic separation reading module (2) integrates a magnetic separation component and a reading component. The magnetic separation component includes an acid liquid filling module (2-1), a mixing module (2-4), a waste liquid extraction module (2-2), a waste liquid needle driving module (2-6), a waste liquid needle module (2-9), and a cleaning liquid filling module (2-8). The reading component includes a shutter module (2-5), a photon counting module (2-3), and a shading mechanism (2-7).

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