Nutrient solution infusion speed automatic control method for enteral nutrition pump

Abstract

The invention relates to the technical field of biomedical engineering, in particular to a nutrient solution infusion speed automatic control method for an enteral nutrition pump, which comprises the following steps: constructing an initial nutrient solution infusion speed model, and setting an initial speed and a final speed in the initial nutrient solution infusion speed model in combination with physiological information of a patient, acquiring an infusion coefficient in the initial nutrient solution infusion speed model; physiological characteristic parameters of the patient are calculated according to the change condition of the physiological data, in the infusion process of the enteral nutrition pump, infusion coefficients are adjusted in real time through the physiological characteristic parameters, and a current nutrient solution infusion speed model is obtained; and controlling the nutrient solution infusion speed of the enteral nutrition pump by using the current nutrient solution infusion model. According to the method, the individuation and optimization degree of treatment are improved, and the accuracy and controllability of the infusion speed are effectively improved.

Description

Technical Field

[0001] The invention relates to the technical field of biomedical engineering, and in particular to an automatic control method for the infusion speed of a nutrient solution used in an enteral nutrition pump. Background Art

[0002] Enteral nutrition pump is a nutritional infusion pump for nasogastric feeding. It is suitable for patients with nutritional support indications and functional and usable gastrointestinal tract, including patients with difficulty in swallowing and chewing, impaired consciousness or coma leading to inability to eat, patients in stable digestive tract diseases such as digestive tract fistula, short bowel syndrome, inflammatory bowel disease and pancreatitis, and patients in high-catabolism state, such as patients with severe infection, surgery, trauma and large-area burns, as well as chronic wasting diseases such as tuberculosis and tumors. Water, nutrient solution and homemade homogenate are usually infused through a nasogastric tube, with functions such as automatic infusion, end-of-infusion alarm, fast discharge, and reverse axis.

[0003] Generally speaking, doctors will develop a nutrient solution infusion plan based on the patient's nutritional needs and physical condition, and provide guidance on the specific pumping speed. However, for patients with impaired consciousness, unclear consciousness or coma, they cannot effectively provide feedback on their feelings during the infusion process. Therefore, when the pumping speed is inappropriate, the nutritional infusion effect will be unsatisfactory. Summary of the invention

[0004] The invention provides an automatic control method for the nutrient solution infusion speed of an enteral nutrition pump to solve the existing problems.

[0005] The method for automatically controlling the infusion speed of nutrient solution for an enteral nutrition pump of the present invention adopts the following technical scheme:

[0006] One embodiment of the present invention provides a method for automatically controlling the infusion speed of a nutrient solution for an enteral nutrition pump, the method comprising the following steps:

[0007] Acquire the patient's physiological information, the infusion parameters of the enteral nutrition pump, and the energy value and volume of the nutrient solution. The physiological information includes the patient's basic data and physiological data. The basic data are height, weight, age, and gender. The physiological data are blood sugar, body temperature, blood pressure, and heart rate data. The blood sugar, body temperature, blood pressure, and heart rate are real-time time series data.

[0008] Constructing an initial nutrient solution infusion rate model, and setting the initial rate and final rate in the initial nutrient solution infusion rate model in combination with the patient's physiological information, and obtaining the infusion coefficient in the initial nutrient solution infusion rate model;

[0009] The patient's physiological characteristic parameters are calculated according to the changes in physiological data. During the infusion process of the enteral nutrition pump, the infusion coefficient is adjusted in real time using the physiological characteristic parameters to obtain the current nutrient solution infusion speed model;

[0010] The current nutrient solution infusion model is used to control the nutrient solution infusion rate of the enteral nutrition pump.

[0011] Furthermore, the initial nutrient solution infusion rate model is constructed, and the initial rate and the final rate in the initial nutrient solution infusion rate model are set in combination with the patient's physiological information, including the specific method of:

[0012] Obtain the patient's physiological-infusion parameters based on the patient's basic data and the energy value of the nutrient solution;

[0013] A reference infusion rate is preset, and the reference infusion rate is adjusted using physiological-infusion parameters to obtain the current patient's basal infusion rate. A function model is selected and combined with the patient's basal infusion rate to construct an initial nutrient solution infusion rate model containing an infusion coefficient.

[0014] Furthermore, the specific method for obtaining the physiological-infusion parameters is:

[0015] The patient's basal metabolic rate was calculated using the Harris-Benedict formula based on the patient's height, weight, age, and sex;

[0016] The patient's physiological-infusion parameter sl=k / J is obtained according to the patient's basal metabolic rate and the energy value of the nutrient solution, wherein k represents the energy value of the nutrient solution and J represents the patient's basal metabolic rate.

[0017] Furthermore, the specific method for obtaining the initial nutrient solution infusion rate model is:

[0018] Combining physiological-infusion parameters with reference infusion rate, determining the basic infusion rate of the initial nutrient solution infusion rate model;

[0019] Based on the sigmoid function and combined with the basic infusion rate of the nutrient solution infusion rate model, the least squares method is used for curve fitting. During the fitting process, the integral value of the fitting result is ensured to be equal to the volume of the nutrient solution infused this time, thereby obtaining the initial nutrient solution infusion rate model containing the initial infusion coefficient.

[0020] Furthermore, the specific method of calculating the patient's physiological characteristic parameters according to the changes in the physiological data includes:

[0021] The patient's physiological data are divided and fitted to obtain a physiological parameter straight line;

[0022] According to the correlation of the patient's physiological data at the current moment during the infusion process and the change characteristics of the corresponding physiological parameter straight line, the patient's physiological characteristic parameters are calculated.

[0023] Furthermore, the physiological data of the patient are divided and fitted to obtain the physiological parameter straight line, including the following specific methods:

[0024] Obtain the patient's blood sugar, body temperature, blood pressure, and heart rate data from T moments before the start of the infusion to the current moment, and divide the blood sugar, body temperature, blood pressure, and heart rate data into the front segment data and the back segment data using the time corresponding to the start of the infusion;

[0025] Linear fitting is performed on the front-segment data and the back-segment data corresponding to the blood sugar, body temperature, blood pressure and heart rate data, respectively, to obtain the physiological parameter straight lines corresponding to the front-segment data and the back-segment data of each physiological data.

[0026] Furthermore, the specific method for obtaining the physiological characteristic parameters is:

[0027] Obtain the change factor of any physiological data;

[0028] The specific calculation method of the patient's physiological characteristic parameters at the current moment is:

[0029]

[0030] Where s∈{Tw,Xy,Xl}; Tw represents body temperature data; Xy represents blood pressure data; Xl represents heart rate data; sc represents the physiological characteristic parameters of the patient at the current moment; p(Xt,s) represents the Pearson correlation coefficient between physiological data s and blood glucose data; y(s) represents the change factor of physiological data s; k2(Xt) represents the slope of the physiological parameter straight line corresponding to the subsequent data of blood glucose data; e represents a natural constant.

[0031] Furthermore, the specific method for obtaining the change factor of the physiological data is:

[0032] For any physiological data, the variation factor is calculated according to the difference in slope and intercept of the physiological parameter straight line corresponding to the anterior segment data and the posterior segment data of the physiological data.

[0033] Furthermore, the specific calculation method of the variation factor is:

[0034]

[0035] Among them, k2(s) represents the slope of the physiological parameter straight line corresponding to the posterior data of the physiological data s; k1(s) represents the slope of the physiological parameter straight line corresponding to the anterior data of the physiological data s; b2(s) represents the intercept of the physiological parameter straight line corresponding to the posterior data of the physiological data s; b1(s) represents the intercept of the physiological parameter straight line corresponding to the anterior data of the physiological data s; || represents the absolute value sign; c is the preset hyperparameter.

[0036] Furthermore, during the infusion process of the enteral nutrition pump, the infusion coefficient is adjusted in real time using the physiological characteristic parameters to obtain the current nutrient solution infusion rate model, including the specific method of:

[0037] By using the physiological characteristic parameters of the patient at the current moment and the change trends of the physiological parameter straight lines corresponding to the front-segment data and the back-segment data of the blood sugar data, the infusion coefficient is adjusted to obtain the adjusted infusion coefficient at the current moment;

[0038] The adjusted infusion coefficient at the current moment is used as the input of the infusion coefficient in the initial nutrient solution infusion rate model to obtain the nutrient solution infusion rate model at the current moment, which is recorded as the current nutrient solution infusion rate model.

[0039] The beneficial effects of the technical solution of the present invention are: adjusting the infusion speed in real time according to the specific needs of the patient, ensuring that the input of the nutrient solution meets the requirements of individualized treatment, and avoiding the risks of too fast or too slow infusion. The reliability and stability of the treatment effect are improved through automatic control, and the response speed and accuracy of the system are enhanced through precise infusion monitoring and feedback mechanisms, making the nutrient solution infusion process smoother, avoiding sudden fluctuations in the infusion speed, and ensuring the continuity and stability of the treatment process. The automated control method can dynamically adjust the infusion speed according to the real-time physiological state of the patient, so as to better adapt to the individual differences of the patient, improve the personalization and optimization of the treatment, and effectively improve the accuracy and controllability of the infusion speed, thereby reducing the risk of accidents caused by improper operation and improving the overall treatment safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0041] Figure 1 It is a flow chart of the steps of the method for automatically controlling the infusion speed of nutrient solution of an enteral nutrition pump of the present invention;

[0042] Figure 2 This is a schematic diagram of the working principle of the enteral nutrition pump;

[0043] Figure 3 This is a schematic diagram of the nutrient solution infusion rate model when the infusion coefficient is 0.11;

[0044] Figure 4 Schematic diagram of the nutrient solution infusion rate model when the infusion coefficient is 0.06. DETAILED DESCRIPTION

[0045] In order to further explain the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following is a detailed description of the automatic control method of the nutrient solution infusion speed for an enteral nutrition pump proposed by the present invention, its specific implementation method, structure, features and effects, in conjunction with the accompanying drawings and preferred embodiments. In the following description, different "one embodiment" or "another embodiment" does not necessarily refer to the same embodiment. In addition, specific features, structures or characteristics in one or more embodiments may be combined in any suitable form.

[0046] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0047] The specific scheme of the method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump provided by the present invention is described in detail below with reference to the accompanying drawings.

[0048] See also Figure 1 , which shows a flow chart of the steps of a method for automatically controlling the infusion speed of a nutrient solution for an enteral nutrition pump provided by an embodiment of the present invention, the method comprising the following steps:

[0049] Step S001: Acquire the patient's physiological information, the infusion parameters of the enteral nutrition pump, and the energy value and volume of the nutrient solution.

[0050] It should be noted that in clinical applications, it is crucial to ensure that the enteral nutrition pump can accurately adjust the infusion speed and time according to the patient's physiological state to avoid adverse effects on the patient due to inappropriate infusion speed (such as gastrointestinal discomfort caused by too fast infusion or nutrient absorption affected by too slow infusion). Therefore, the parameter data of the patient's own condition and the operation of the enteral nutrition pump should be analyzed to automatically control the nutrient solution infusion process of the enteral nutrition pump, such as Figure 2 Shown is a schematic diagram of the working principle of the enteral nutrition pump.

[0051] Specifically, in order to implement the automatic control method for the nutrient solution infusion speed of the enteral nutrition pump proposed in this embodiment, it is first necessary to collect the patient's physiological information and the infusion parameters of the enteral nutrition pump. The specific process is as follows:

[0052] First, the patient's physiological information is obtained, which includes the patient's basic data and physiological data. The basic data are height, weight, age, and gender, and the physiological data are blood sugar, body temperature, blood pressure, and heart rate data, among which blood sugar, body temperature, blood pressure, and heart rate are real-time time series data.

[0053] The blood sugar, body temperature, blood pressure and heart rate data are collected using a blood glucose meter, an intelligent thermometer, an intelligent blood pressure meter and an electrocardiogram monitor, respectively.

[0054] Then, the infusion parameters of the enteral nutrition pump as well as the energy value and volume of the nutrition solution were obtained.

[0055] The infusion parameters of the enteral nutrition pump include: infusion speed and infusion time, and the energy value of the nutrient solution is calculated by the content of each component in the nutrient solution during this infusion.

[0056] It should be noted that in order to enable the enteral nutrition pump to timely feedback and adjust the infusion speed of the enteral nutrition pump according to changes in the patient's physiological information during the process of nutrient solution infusion, the blood glucose meter, smart blood pressure monitor and electrocardiogram monitor are all connected to the enteral nutrition pump for communication.

[0057] So far, the patient's physiological information and the infusion parameters of the enteral nutrition pump are obtained through the above method.

[0058] Step S002: construct an initial nutrient solution infusion rate model, set the initial rate and final rate in the initial nutrient solution infusion rate model in combination with the patient's physiological information, and obtain the infusion coefficient in the initial nutrient solution infusion rate model.

[0059] It should be noted that in actual clinical nursing work, when using an enteral nutrition pump to infuse nutrient solution, it is usually performed at a lower infusion rate at the beginning to give the patient a sufficient adaptation period and avoid a strong stress response in the patient's body. As the infusion process proceeds, the infusion rate should be gradually increased from the initial low-speed infusion to ensure that the infusion rate of the nutrient solution matches the patient's gastrointestinal motility and digestive ability, so that the patient can achieve good nutrient absorption. However, the final infusion rate cannot be too high, otherwise too fast an infusion may cause indigestion or physical discomfort in the patient.

[0060] Specifically, in step S201, the physiological-infusion parameters of the patient are obtained according to the basic data of the patient and the energy value of the nutrient solution.

[0061] The specific method for obtaining the physiological-infusion parameters is:

[0062] First, the patient's basal metabolic rate was calculated using the Harris-Benedict formula based on the patient's height, weight, age, and gender.

[0063] Then, the patient's physiological-infusion parameter sl=k / J is obtained according to the patient's basal metabolic rate and the energy value of the nutrient solution, wherein k represents the energy value of the nutrient solution and J represents the patient's basal metabolic rate.

[0064] Step S202, preset a reference infusion rate, adjust the reference infusion rate using physiological-infusion parameters, obtain the current patient's basic infusion rate, select a function model and construct an initial nutrient solution infusion rate model containing an infusion coefficient in combination with the patient's basic infusion rate.

[0065] As an embodiment, the specific method for constructing the initial nutrient solution infusion rate model includes:

[0066] First, the basic infusion rate of the initial nutrient solution infusion rate model was determined by combining the physiological infusion parameters with the reference infusion rate.

[0067] As an embodiment, the specific calculation method of the basic infusion rate is:

[0068] s=s 0 ×sl,s 0 ∈{s1,s2}

[0069] Where, s represents the basic infusion rate of the enteral nutrition pump, s 0 represents the reference infusion rate of the enteral nutrition pump, sl represents the patient's physiological-infusion parameter, s1 represents the reference initial infusion rate of the enteral nutrition pump, and s2 represents the reference final infusion rate of the enteral nutrition pump.

[0070] It should be noted that, under normal circumstances, when patients are given nutrient solution infusions through an enteral nutrition pump, there is a reference infusion rate for the enteral nutrition pump based on clinical experience, where the reference initial infusion rate is usually 40-60 ml / h, and the reference final infusion rate is usually 100-150 mL / h.

[0071] Then, based on the sigmoid function and combined with the basic infusion rate of the nutrient solution infusion rate model, the least squares method is used for curve fitting. During the fitting process, the integral value of the fitting result is ensured to be equal to the volume of the nutrient solution infused this time, thereby obtaining the initial nutrient solution infusion rate model containing the initial infusion coefficient.

[0072] As an embodiment, the nutrient solution infusion rate model formula is expressed as:

[0073]

[0074] Among them, Sz t represents the nutrient solution infusion rate model; s2′ represents the final infusion rate of the enteral nutrition pump; s1′ represents the initial infusion rate of the enteral nutrition pump; t represents the time, A represents the infusion coefficient of the nutrient solution infusion rate model, and B is the fitting parameter.

[0075] A and B are obtained by least squares fitting.

[0076] It should be noted that the embodiment of the present invention uses data-driven design of the initial nutrient solution infusion rate model to avoid errors or inadaptability that may be caused by traditional empirical methods, improve the accuracy of treatment, and effectively avoid adverse reactions caused by inappropriate infusion rate.

[0077] So far, the initial nutrient solution infusion rate model of the enteral nutrition pump is obtained through the above method.

[0078] Step S003: Calculate the patient's physiological characteristic parameters according to the changes in physiological data. During the infusion process of the enteral nutrition pump, use the physiological characteristic parameters to adjust the infusion coefficient in real time to obtain the current nutrient solution infusion speed model.

[0079] It should be noted that, usually, in order to enable patients to adapt to the infusion process of the enteral nutrition pump, it is necessary to divide the nutrient solution infusion model into different states according to the patient's physical sign response (i.e., changes in physiological data) during the infusion process, and adjust the parameters of the nutrient solution infusion rate model in different states to ensure that the patient can gradually adapt to the infusion process of the enteral nutrition pump, avoid overly strong rejection reactions in the body, and thus improve the infusion effect of the nutrient solution.

[0080] In addition, in the nutrient solution infusion rate model of the enteral nutrition pump, the infusion coefficient affects the rate at which the nutrient solution changes from the initial infusion rate to the final infusion rate, such as Figure 3 and Figure 4 The figure shows the schematic diagram of the nutrient solution infusion rate model when the infusion coefficient is 0.11 and 0.06 respectively. Figure 3 and Figure 4 It can be seen that the smaller the infusion coefficient is, the slower the infusion speed changes from the initial infusion speed to the final infusion speed during the nutrient solution infusion process. Therefore, the embodiment of the present invention chooses to adjust the infusion coefficient in the nutrient solution infusion speed model by analyzing the patient's physiological data during the infusion process, so as to achieve subsequent intelligent control of the nutrient solution infusion speed of the enteral nutrition pump, so as to improve the infusion effect of the enteral nutrition pump and the patient's clinical experience.

[0081] Specifically, step S301 is to analyze the change characteristics corresponding to the patient's physiological data before and after the infusion, and calculate the patient's physiological characteristic parameters.

[0082] It should be noted that through real-time physiological data monitoring, the patient's blood sugar, body temperature, blood pressure, heart rate and other physiological parameters are continuously monitored. If abnormalities are found, the infusion speed is adjusted in time. For example, if the patient's blood sugar rises too quickly, the system should automatically reduce the infusion speed and gradually return to normal speed after the blood sugar recovers.

[0083] Firstly, the physiological data of the patient are divided and fitted to obtain the physiological parameter straight line.

[0084] As an embodiment, the specific method for obtaining the physiological characteristic parameters of the patient includes:

[0085] 1) Obtain the patient's blood sugar, body temperature, blood pressure, and heart rate data from T moments before the start of infusion to the current moment, and use the time corresponding to the start of infusion to divide the blood sugar, body temperature, blood pressure, and heart rate data into front-end data and back-end data.

[0086] 2) Linear fitting is performed on the front-segment data and the back-segment data corresponding to the blood sugar, body temperature, blood pressure and heart rate data, respectively, to obtain the physiological parameter straight line corresponding to the front-segment data and the back-segment data of each physiological data.

[0087] It should be noted that the parameter T is preset to 30 minutes based on experience, and can be adjusted according to actual conditions, and is not specifically limited in the embodiment of the present invention.

[0088] Then, according to the correlation of the patient's physiological data at the current moment during the infusion process and the change characteristics of the corresponding physiological parameter straight line, the patient's physiological characteristic parameters are calculated.

[0089] As an embodiment, the specific method for calculating the physiological characteristic parameters of the patient at the current moment is:

[0090]

[0091] Where s∈{Tw,Xy,Xl}; Tw represents body temperature data; Xy represents blood pressure data; Xl represents heart rate data; sc represents the physiological characteristic parameters of the patient at the current moment; p(Xt,s) represents the Pearson correlation coefficient between physiological data s and blood glucose data; y(s) represents the change factor of physiological data s; k2(Xt) represents the slope of the physiological parameter straight line of blood glucose data corresponding to the latter data; k2(s) represents the slope of the physiological parameter straight line of physiological data s corresponding to the latter data; k1(s) represents the slope of the physiological parameter straight line of physiological data s corresponding to the former data; b2(s) represents the intercept of the physiological parameter straight line of physiological data s corresponding to the latter data; b1(s) represents the intercept of the physiological parameter straight line of physiological data s corresponding to the former data; || represents the absolute value symbol; e represents a natural constant; c is a preset hyperparameter.

[0092] It should be noted that the hyperparameter c is preset to 0.1 based on experience to avoid the situation where the denominator is 0. The specific size can be adjusted according to actual conditions and is not limited in the embodiment of the present invention.

[0093] It should be noted that, after the start of nutrient solution infusion, if the patient's blood sugar increases too quickly until the current moment, it means that the infusion speed of the nutrient solution is too high, which can easily cause physical discomfort to the patient; in addition, the more correlated the patient's body temperature, blood pressure, and heart rate data are with the changes in blood sugar data, the greater the impact of blood sugar data on body temperature, blood pressure, and heart rate data during the nutrient solution infusion process. At the same time, when the patient's body temperature, blood pressure, and heart rate data change greatly before and after, the nutrient solution infusion speed causes the patient to feel strongly uncomfortable. Therefore, the larger the value of the corresponding physiological characteristic parameter, the greater the subsequent adjustment of the infusion coefficient in the nutrient solution infusion speed model at the current moment.

[0094] It should be noted that the physiological characteristic parameters reflect the patient's physiological response to the infusion rate at the current moment during the infusion process. The larger the physiological characteristic parameters are, the more unreasonable the infusion rate at the current moment is, the more obvious the patient's physiological response is, and the stronger the discomfort is.

[0095] Step S302, during the infusion process of the enteral nutrition pump, the infusion coefficient is adjusted in real time using the physiological characteristic parameters to obtain a current nutrient solution infusion speed model.

[0096] It should be noted that since the infusion process of the enteral nutrition pump is a dynamic process and the patient's body will gradually adapt to the infusion speed of the nutrient solution, as the infusion process proceeds, the infusion speed of the enteral nutrition pump should be adaptively and intelligently adjusted based on the patient's physiological condition, maintaining a slower infusion speed in the early stage, and gradually increasing the infusion speed after the patient's physiological response gradually stabilizes.

[0097] Firstly, the infusion coefficient is adjusted using the physiological characteristic parameters of the patient at the current moment and the change trends of the physiological parameter lines corresponding to the front-segment data and the back-segment data of the blood sugar data to obtain the adjusted infusion coefficient at the current moment.

[0098] As an embodiment, the specific calculation method of the adjusted infusion coefficient is:

[0099] A′={e -sc +exp[-(k2(Xt)-k1(Xt))]}×A 0

[0100] Wherein, A′ represents the adjusted infusion coefficient of the nutrient solution infusion rate model at the current moment; sc represents the physiological characteristic parameter of the patient at the current moment; k2(Xt) represents the slope of the physiological parameter straight line of the blood sugar data corresponding to the latter data; k1(Xt) represents the slope of the physiological parameter straight line of the blood sugar data corresponding to the former data; A 0 Indicates the infusion coefficient of the nutrient solution infusion rate model at the current moment;

[0101] It should be noted that the adjustment process of the infusion coefficient is during the infusion process of the nutrient solution. As time goes by, an adjustment will be made at each moment. Each adjustment is an iterative adjustment of the infusion coefficient after the last adjustment. During the first adjustment, the adjusted infusion coefficient is the initial infusion coefficient in the initial nutrient solution infusion rate model.

[0102] Then, the adjusted infusion coefficient at the current moment is used as the input of the infusion coefficient in the initial nutrient solution infusion rate model to obtain the nutrient solution infusion rate model at the current moment, which is recorded as the current nutrient solution infusion rate model.

[0103] It should be noted that during the infusion process, as the patient digests and absorbs the nutrient solution, the patient's blood sugar will gradually rise. During this process, when the patient feels uncomfortable due to the rapid infusion speed, the heart rate will accelerate, blood circulation will accelerate, and blood pressure and body temperature will increase. Therefore, it is necessary to slow down the rate of increase of the infusion speed to avoid the patient from feeling more uncomfortable.

[0104] So far, the current nutrient solution infusion rate model is obtained through the above method.

[0105] Step S004: using the current nutrient solution infusion model to control the nutrient solution infusion speed of the enteral nutrition pump.

[0106] Specifically, the infusion rate at the current moment in the current nutrient solution infusion model is obtained as the infusion rate of the enteral nutrition pump at the current moment.

[0107] In addition, the enteral nutrition pump can record the corresponding infusion coefficient of the same patient at each moment during the infusion process, so as to be directly used in the next nutrient solution infusion process.

[0108] It should be noted that the enteral nutrition pump in the embodiment of the present invention can accurately adjust the infusion parameters according to the patient's individualized physiological data and dynamic feedback. This can not only ensure the optimal infusion speed of the nutrient solution, but also maximize the treatment effect, while reducing the side effects and adverse reactions of the patient during the infusion process.

[0109] At this point, this embodiment is completed.

[0110] It should be noted that the exp(-x) model used in this embodiment is only used to indicate that the negative correlation and the result of the constraint model output are in the interval (0,1). In specific implementation, it can be replaced with other models with the same purpose. This embodiment only uses the exp(-x) model as an example for description without making specific limitations on it, where x refers to the input of the model.

[0111] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A method for automatically controlling the infusion rate of nutrient solution for an enteral nutrition pump, characterized in that: The method comprises the following steps: Acquire the patient's physiological information, the infusion parameters of the enteral nutrition pump, and the energy value and volume of the nutrient solution. The physiological information includes the patient's basic data and physiological data. The basic data are height, weight, age, and gender. The physiological data are blood sugar, body temperature, blood pressure, and heart rate data. The blood sugar, body temperature, blood pressure, and heart rate are real-time time series data. Constructing an initial nutrient solution infusion rate model, and setting the initial rate and final rate in the initial nutrient solution infusion rate model in combination with the patient's physiological information, and obtaining the infusion coefficient in the initial nutrient solution infusion rate model; The patient's physiological characteristic parameters are calculated according to the changes in physiological data. During the infusion process of the enteral nutrition pump, the infusion coefficient is adjusted in real time using the physiological characteristic parameters to obtain the current nutrient solution infusion speed model; The current nutrient solution infusion model is used to control the nutrient solution infusion rate of the enteral nutrition pump.

2. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 1, characterized in that: The initial nutrient solution infusion speed model is constructed, and the initial speed and the final speed in the initial nutrient solution infusion speed model are set in combination with the patient's physiological information, including the following specific methods: Obtain the patient's physiological-infusion parameters based on the patient's basic data and the energy value of the nutrient solution; A reference infusion rate is preset, and the reference infusion rate is adjusted using physiological-infusion parameters to obtain the current patient's basal infusion rate. A function model is selected and combined with the patient's basal infusion rate to construct an initial nutrient solution infusion rate model containing an infusion coefficient.

3. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 2, characterized in that: The specific method for obtaining the physiological-infusion parameters is: The patient's basal metabolic rate was calculated using the Harris-Benedict formula based on the patient's height, weight, age, and sex; The patient's physiological-infusion parameter sl=k / J is obtained according to the patient's basal metabolic rate and the energy value of the nutrient solution, wherein k represents the energy value of the nutrient solution and J represents the patient's basal metabolic rate.

4. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 2, characterized in that: The specific method for obtaining the initial nutrient solution infusion rate model is: Combining physiological-infusion parameters with reference infusion rate, determining the basic infusion rate of the initial nutrient solution infusion rate model; Based on the sigmoid function and combined with the basic infusion rate of the nutrient solution infusion rate model, the least squares method is used for curve fitting. During the fitting process, the integral value of the fitting result is ensured to be equal to the volume of the nutrient solution infused this time, thereby obtaining the initial nutrient solution infusion rate model containing the initial infusion coefficient.

5. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 1, characterized in that: The specific method of calculating the patient's physiological characteristic parameters according to the changes in the physiological data includes: The patient's physiological data are divided and fitted to obtain a physiological parameter straight line; According to the correlation of the patient's physiological data at the current moment during the infusion process and the change characteristics of the corresponding physiological parameter straight line, the patient's physiological characteristic parameters are calculated.

6. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 5, characterized in that: The specific method of dividing and fitting the physiological data of the patient to obtain the physiological parameter straight line includes: Obtain the patient's blood sugar, body temperature, blood pressure, and heart rate data from T moments before the start of the infusion to the current moment, and divide the blood sugar, body temperature, blood pressure, and heart rate data into the front segment data and the back segment data using the time corresponding to the start of the infusion; Linear fitting is performed on the front-segment data and the back-segment data corresponding to the blood sugar, body temperature, blood pressure and heart rate data, respectively, to obtain the physiological parameter straight lines corresponding to the front-segment data and the back-segment data of each physiological data.

7. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 6, characterized in that: The specific method for obtaining the physiological characteristic parameters is: Obtain the change factor of any physiological data; The specific calculation method of the patient's physiological characteristic parameters at the current moment is: Where s∈{Tw,Xy,Xl}; Tw represents body temperature data; Xy represents blood pressure data; Xl represents heart rate data; sc represents the physiological characteristic parameters of the patient at the current moment; p(Xt,s) represents the Pearson correlation coefficient between physiological data s and blood glucose data; y(s) represents the change factor of physiological data s; k2(Xt) represents the slope of the physiological parameter straight line corresponding to the subsequent data of blood glucose data; e represents a natural constant.

8. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 7, characterized in that: The specific method for obtaining the change factor of the physiological data is: For any physiological data, the variation factor is calculated according to the difference in slope and intercept of the physiological parameter straight line corresponding to the anterior segment data and the posterior segment data of the physiological data.

9. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 8, characterized in that: The specific calculation method of the variation factor is: Among them, k2(s) represents the slope of the physiological parameter straight line corresponding to the posterior data of the physiological data s; k1(s) represents the slope of the physiological parameter straight line corresponding to the anterior data of the physiological data s; b2(s) represents the intercept of the physiological parameter straight line corresponding to the posterior data of the physiological data s; b1(s) represents the intercept of the physiological parameter straight line corresponding to the anterior data of the physiological data s; || represents the absolute value sign; c is the preset hyperparameter.

10. The method for automatically controlling the nutrient solution infusion speed of an enteral nutrition pump according to claim 1, characterized in that: During the infusion process of the enteral nutrition pump, the infusion coefficient is adjusted in real time using the physiological characteristic parameters to obtain the current nutrient solution infusion speed model, including the following specific methods: By using the physiological characteristic parameters of the patient at the current moment and the change trends of the physiological parameter straight lines corresponding to the front-segment data and the back-segment data of the blood sugar data, the infusion coefficient is adjusted to obtain the adjusted infusion coefficient at the current moment; The adjusted infusion coefficient at the current moment is used as the input of the infusion coefficient in the initial nutrient solution infusion rate model to obtain the nutrient solution infusion rate model at the current moment, which is recorded as the current nutrient solution infusion rate model.

Images