Oil phase inclusion, oil phase inclusion preparation method and skin care water dosage form composition

Abstract

The embodiment of the invention discloses an oil-phase inclusion, a preparation method of the oil-phase inclusion and a specific oil-phase inclusion of a skin-care water dosage form composition, and the specific oil-phase inclusion comprises 0.5-30 parts of an inclusion; 30 to 90 parts of grease; the inclusion is vitamin C and / or vitamin C derivatives, the grease comprises first grease, the oil phase gel is disteardimonium hectorite, the first grease is non-polar grease, and the LogP value of the first grease is smaller than or equal to 7.5. The oil-phase inclusion prepared in the embodiment can effectively avoid the problem that the inclusion is oxidized and further loses antioxidant activity, so that the storage stability of the inclusion is greatly improved.

Description

Technical Field

[0001] The embodiments of the present disclosure relate to the field of biotechnology, and specifically to oil phase inclusions, a method for preparing oil phase inclusions, and a water-based formulation composition for skin care. Background Art

[0002] Vitamin C (VC), also known as ascorbic acid, is widely used in the cosmetics field as a whitening ingredient. However, vitamin C is unstable and easily oxidized, thereby losing its antioxidant activity.

[0003] The above information disclosed in this Background section is only for enhancement of understanding of the background of the inventive concept and therefore it may contain information that does not form the prior art that is already known to a person of ordinary skill in the art. Summary of the invention

[0004] The content of this disclosure is used to introduce concepts in a brief form, which will be described in detail in the detailed implementation section below. The content of this disclosure is not intended to identify the key features or essential features of the technical solution claimed for protection, nor is it intended to limit the scope of the technical solution claimed for protection.

[0005] Some embodiments of the present disclosure propose oil phase inclusions, methods for preparing oil phase inclusions, and water-based skin care compositions to solve one or more of the technical problems mentioned in the above background technology section.

[0006] In the first aspect, some embodiments of the present disclosure provide an oil phase inclusion, comprising: an inclusion, 0.5 to 30 parts; an oil, 30 to 90 parts; and an oil phase gelling agent, 0.5 to 30 parts, wherein the inclusion is vitamin C and / or a vitamin C derivative, the oil comprises: a first oil, the oil phase gelling agent is disteardimethylammonium hectorite, the first oil is a non-polar oil, and the LogP value of the first oil is ≤7.5.

[0007] Optionally, the number of portions of the wrapped object is 0.5 to 15 portions, 0.5 to 10 portions, 10 portions, or 15 portions.

[0008] Optionally, the mass ratio of the oil phase gel to the oil is 1:3-10.

[0009] Optionally, the mass ratio of the oil phase gel and the oil can be any of the following mass ratios: 1:4-10, 1:6-10, 1:8-10, 1:3-8, 1:4-8, 1:4, 1:6, 1:8, 1:10.

[0010] Optionally, the vitamin C derivatives include one or more of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glucoside, 3-o-ethyl ascorbic acid, and ascorbyl tetraisopalmitate.

[0011] Optionally, the first oil comprises one or more of propylene carbonate, propylene glycol dicaprylate / dicaprate, coconut oil caprylate / silicate, dibutyl adipate, isononyl isononanoate, neopentyl glycol di(ethylhexanoate), and pentaerythritol tetra(ethylhexanoate).

[0012] Optionally, in order to ensure the activation effect on the oil phase gel, improve the skin feel during use, and ensure compatibility with other components, the first oil includes: propylene carbonate, propylene glycol dicaprylate / dicaprate.

[0013] Optionally, the above-mentioned grease further includes: a second grease, wherein the LogP value of the above-mentioned second grease is greater than the logP value of the above-mentioned first grease.

[0014] Optionally, 8≤logP value of the second oil≤17.

[0015] Optionally, the second oil comprises one or more of hydrogenated polyisobutene, isohexadecane, jojoba oil, squalane, and octyl siloxane.

[0016] Optionally, in order to improve skin affinity and skin absorbability, and to better protect vitamin C and / or vitamin C derivatives from damage caused by free radical attacks, the second oil includes one or more of hydrogenated polyisobutene, jojoba oil, and squalane.

[0017] Optionally, the mass ratio of the first oil and the second oil can be any of the following mass ratios: 1:0.1-5, 1:0.1-4, 1:0.1-3, 1:0.1-2, 1:0.5-2, 1:0.5-4, 1:0.5-5, 1:0.6, 1:0.67, 1:1.

[0018] Optionally, the first oil is propylene carbonate, the second oil is hydrogenated polyisobutylene, the mass ratio of the first oil to the second oil is 1:0.1-5; the mass ratio of the oil phase gelling agent to the oil is 1:3-10.

[0019] Optionally, the first oil is propylene carbonate, the second oil is hydrogenated polyisobutylene, the mass ratio of the first oil to the second oil is 1:0.5-2; the mass ratio of the oil phase gelling agent to the oil is 1:4-10.

[0020] Optionally, the first oil is propylene carbonate, the second oil is hydrogenated polyisobutylene, and the mass ratio of the first oil to the second oil is 1:5; the mass ratio of the oil phase gelling agent to the oil is 1:8-10.

[0021] Optionally, the above-mentioned oil phase inclusions, wherein, further include one or more of retinol, retinol palmitate, retinol propionate, retinol acetate, ergothioneine, and arbutin. In a second aspect, some embodiments of the present disclosure provide a method for preparing an oil phase inclusion, wherein the above-mentioned method for preparing an oil phase inclusion is used to prepare the above-mentioned oil phase inclusion as described in the first aspect, comprising: at a preset temperature, dispersing and swelling the oil phase gel and oil uniformly to obtain a mixture; adding the inclusions to the above-mentioned mixture, and stirring the mixture under homogeneous stirring until it is cooled to room temperature to obtain the oil phase inclusions.

[0022] Optionally, the preset temperature is 55°C to 85°C.

[0023] In a third aspect, some embodiments of the present disclosure provide a water-based skin care composition, wherein the water-based skin care composition comprises: 1 to 15 parts of the oil phase inclusions as described above in the first aspect; 84.2 to 98.8 parts of water; and 0.2 to 0.8 parts of a water-based thickener.

[0024] Optionally, the above-mentioned skin care water dosage composition further includes: other auxiliary materials: 0.01 to 15 parts.

[0025] Optionally, the water phase thickener may include one or more of carbomer, xanthan gum, polyacrylate cross-linked polymer-6, carrageenan, hydroxyethyl cellulose, and guar gum.

[0026] Optionally, the carbomer may be carbomer U30 / ETD 2020.

[0027] Optionally, the other auxiliary materials may include: one or more of a chelating agent, a preservative, a polyol moisturizer and a pH regulator.

[0028] The above-mentioned various embodiments of the present disclosure have the following beneficial effects: through the oil phase inclusions of some embodiments of the present disclosure, the long-term and stable preservation of the included object (vitamin C and / or vitamin C derivatives) can be achieved. Specifically, the structure of disteardimethylammonium hectorite is a planar layered structure. After mixing with oil, the first oil will play the purpose of activating the disteardimethylammonium hectorite, that is, increasing the interlayer distance of the disteardimethylammonium hectorite, so that the disteardimethylammonium hectorite obtains a microporous structure with uniform and consistent active energy performance. With the microporous structure as the skeleton, the oil can be evenly filled in the skeleton, thereby achieving the purpose of reducing the fluidity of the oil, so as to form an oil phase inclusion that can stably wrap the included object. The above-mentioned oil phase inclusions can effectively avoid the problem of oxidation of the included object and then losing antioxidant activity, thereby greatly improving the storage stability of the included object. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The above and other features, advantages and aspects of the embodiments of the present disclosure will become more apparent with reference to the following detailed description in conjunction with the accompanying drawings. Throughout the accompanying drawings, the same or similar reference numerals represent the same or similar elements. It should be understood that the drawings are schematic and the elements are not necessarily drawn to scale.

[0030] Figure 1 is a comparison diagram of the appearance of the water-dispersible preparations corresponding to Example Group A of some embodiments of the present disclosure;

[0031] Figure 2 is another appearance comparison diagram of the water-dispersible preparation corresponding to Example Group A of some embodiments of the present disclosure;

[0032] Figure 3 is a schematic diagram of the appearance of a water-dispersible preparation corresponding to Example B-8 of some embodiments of the present disclosure;

[0033] Figure 4 It is a schematic diagram of the appearance of the water-dispersible preparation corresponding to Example B-13 of some embodiments of the present disclosure. DETAILED DESCRIPTION

[0034] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although certain embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be construed as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided to provide a more thorough and complete understanding of the present disclosure. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0035] It should also be noted that, for ease of description, only the parts related to the invention are shown in the drawings. In the absence of conflict, the embodiments and features in the embodiments of the present disclosure can be combined with each other.

[0036] It should be noted that the modifications of "one" and "plurality" mentioned in the present disclosure are illustrative rather than restrictive, and those skilled in the art should understand that unless otherwise clearly indicated in the context, it should be understood as "one or more".

[0037] It should be noted that the term “about” mentioned in the present disclosure, when used to define a numerical value, means ±5% of the specified numerical value.

[0038] It should be noted that the term "%" mentioned in the present disclosure means mass % unless otherwise specified.

[0039] It should be noted that the "normal temperature" mentioned in the present disclosure refers to the ambient temperature, that is, no special heating or cooling treatment has been performed.

[0040] Explanation of terms

[0041] The term "Vitamin C", also known as ascorbic acid, is odorless, sour in taste, easily soluble in water, has strong reducing properties, and is in powder form.

[0042] The term "disteardimethylammonium hectorite" refers to an organically modified clay which has a certain hydrophobicity.

[0043] The term "non-polar oil" refers to a fatty compound that lacks polar groups and has low polarity and high hydrophobicity.

[0044] The term "sodium ascorbyl phosphate" is a water-soluble vitamin C derivative that is more stable and less susceptible to oxidation than vitamin C. Its chemical formula is C 12 H 13 Na2O9P.

[0045] The term "magnesium ascorbyl phosphate" is a water-soluble vitamin C derivative that is more stable and less susceptible to oxidation than vitamin C. Its chemical formula is C 12 H 14 MgO9P.

[0046] The term "ascorbyl glucoside" is a water-soluble vitamin C derivative that has higher stability and skin permeability than vitamin C. Its chemical formula is C 12 H 20 O 12 .

[0047] The term "3-o-ethyl ascorbic acid" is a water-soluble vitamin C derivative that inherits the excellent properties of vitamin C and has better stability and skin permeability. Its chemical formula is C8H 10 O6.

[0048] The term "ascorbyl tetraisopalmitate" is a vitamin C derivative that is stable at high temperatures and has good solubility in oils. Its chemical formula is C 70 H 128 O 10 .

[0049] The term "propylene carbonate" is a colorless, transparent, liquid organic compound with a chemical formula of C4H6O3.

[0050] The term "propylene glycol dicaprylate / dicaprate" is a mixed fat obtained by esterification of propylene glycol with caprylic and capric acid.

[0051] The term "coco-caprylate / silicate" refers to a mixed fat obtained by esterification of coconut alcohol with caprylic acid and silicic acid.

[0052] The term "dibutyl adipate" is an organic compound with the chemical formula C 14 H 26 O4.

[0053] The term "isononyl isononanoate" is an organic compound with the chemical formula C 18 H 36 O2.

[0054] The term "neopentyl glycol diethylhexanoate" is an organic compound with the chemical formula C 21 H 40 O4.

[0055] The term "pentaerythritol tetra(ethylhexanoate)" is an organic compound with the chemical formula C 37 H 68 O8.

[0056] The term "hydrogenated polyisobutylene", also known as synthetic squalane and isotriacontane, is a hydrocarbon oil obtained by hydrogenating squalene extracted from the liver of deep-sea sharks.

[0057] The term "isohexadecane" is a highly branched alkane with the formula C 16 H 34 .

[0058] The term "jojoba oil", also known as jojoba oil, is an oil obtained from jojoba seeds.

[0059] The term "squalane" refers to a hydrocarbon obtained by hydrogenation of squalene, with the chemical formula C30 H 62 .

[0060] The term "caprylylsiloxane" is a type of organosilicone.

[0061] The term "carbomer" refers to an acrylic acid cross-linked resin obtained by cross-linking pentaerythritol and acrylic acid, and is a commonly used rheology regulator.

[0062] The term "xanthan gum" is also known as xanthan gum, which is a monosporic polysaccharide produced by fermentation of Pseudocanthomonas.

[0063] The term "polyacrylate crosspolymer-6" is a skin-friendly synthetic polymer commonly used as a thickener and film former.

[0064] The term "carrageenan", also known as carrageenan, carrageenan, etc., is a general term for a group of linear sulfated polysaccharides extracted from marine red algae.

[0065] The term "hydroxyethyl cellulose" is a white or light yellow, colorless, odorless fibrous or powdery solid prepared by the etherification reaction of alkaline cellulose and ethylene oxide.

[0066] The term "guar gum" is also known as guar gum, which is an extract of guar beans and is a galactomannan.

[0067] The term "dioctyl carbonate", chemical formula C 17 H 34 O3.

[0068] The term "dioctyl ether" is commonly used in surfactants, with the chemical formula C 16 H 34 O.

[0069] The term "cetyl ethylhexanoate" is also known as hexadecyl ethylhexanoate, with the chemical formula C 24 H 48 O2.

[0070] The term "C12-15 alcohol benzoate" is a colorless, odorless, transparent oily liquid.

[0071] The term "castor oil / IPDI copolymer" is insoluble in water and has a stable structure.

[0072] The term "polyethylene wax" is a white, odorless polymer wax.

[0073] The term "dextrin stearate" refers to a compound obtained by esterifying dextrin with stearic acid.

[0074] The term "arginine" is an amino acid compound with the chemical formula C6H 14 N4O2.

[0075] The present disclosure will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0076] Experimental / testing method description

[0077] Among them, this disclosure involves the following 5 test methods, which are as follows:

[0078] (1) logP value test method;

[0079] (2) Methods for evaluating inclusion stability;

[0080] (3) Testing method for uniformity of vitamin C distribution in oil phase inclusions;

[0081] (4) Skin feel evaluation method;

[0082] (5) Stability test method for water dispersion preparation containing oil phase inclusions of vitamin C.

[0083] The specific descriptions of each test method are as follows:

[0084] (1) logP value test method

[0085] Specifically, the shake flask method is used, that is, the compound is dissolved in a two-way system (mixture) consisting of water and 1-octanol, and after sufficient mixing, the two phases (water phase and 1-octanol phase) are allowed to stand and separate, and the concentrations of the compound in the water phase and the 1-octanol phase are respectively measured.

[0086] The logP value is calculated as follows: logP value = lg([C] 正辛醇相 / [C] 水相 ). Among them, [C] 正辛醇相 Characterizes the concentration of the compound in the n-octanol phase. [C] 水相 Characterize the concentration of the compound in the aqueous phase.

[0087] (2) Inclusion stability evaluation method

[0088] Specifically, the prepared oil phase inclusions containing vitamin C are placed in a PET bottle, and placed in a constant temperature insulation box at a temperature of 45±2° C., and the state of the sample is observed and recorded.

[0089] (3) Test method for uniform distribution of vitamin C in oil phase inclusions

[0090] Specifically, after the prepared oil phase inclusions containing vitamin C are placed for one week, the upper, middle and lower three layers of the inclusions are respectively taken for high-performance liquid chromatography testing, and the content differences of the corresponding inclusions are tested.

[0091] (4) Skin feel evaluation method

[0092] Specifically, 30 random users aged between 18 and 45 were selected as subjects. The subjects gave a comprehensive score from the two perspectives of skin residual feeling and thick feeling after applying the water dispersion composition containing the oil phase inclusions of vitamin C on the skin. The score range was [1, 10], and the average of the scores given by the subjects was taken as the skin feeling evaluation score.

[0093] (5) Stability test method for water-dispersible preparations containing oil phase inclusions of vitamin C

[0094] Specifically, the oil phase inclusions containing vitamin C are prepared into a water dispersion preparation. In which, a polyacrylate polymer gel is added to the water phase. The water dispersion preparation is placed in a PET bottle and stored in a constant temperature incubator. At a temperature of 45±2°C, the sample state is observed and recorded (the longest observation period is 180 days).

[0095] In practice, due to the compatibility problem between vitamin C and polyacrylate polymers, when vitamin C is directly added to polyacrylate polymer gel (e.g., Carbo 980, Carbo U21, etc.), the component molecules such as acrylic acid will be aggregated, which is specifically manifested as the rapid reduction of the viscosity of the gel and even flocculation. Therefore, when vitamin C is not effectively wrapped, more vitamin C will be freed into the system when added to the polyacrylate solution, which greatly reduces the viscosity of the gel and cannot form a gel. Therefore, it will be observed that the system is obviously thinned, and the oil phase inclusions float or even aggregate, not in a particle state. Thus, based on the relationship between vitamin C and the polyacrylate solution, the encapsulation stability of the oil phase inclusions containing vitamin C can be verified.

[0096] LogP Value Explanation

[0097] The LogP values ​​of some oils and fats involved in the present disclosure are shown in Table 1 below:

[0098] Table 1 (LogP value of some oils and fats)

[0099]

[0100] Preparation method description

[0101] The preparation method of the oil phase inclusions involved in the present disclosure comprises the following steps:

[0102] In the first step, the oil phase gel and oil are dispersed and swollen uniformly at a preset temperature to obtain a mixture.

[0103] In practice, the preset temperature is 55°C to 85°C.

[0104] In the second step, the inclusion body is added into the above mixture, and the mixture is cooled to room temperature under homogeneous stirring to obtain the oil phase inclusion body.

[0105] The preparation method of the water-dispersible preparation of the oil phase inclusion containing vitamin C involved in the present disclosure comprises the following steps:

[0106] Preparation steps: weigh the raw materials according to the following weight parts:

[0107] Vitamin C powder inclusions 5 parts,

[0108] 0.4 parts of aqueous phase thickener,

[0109] The pH of the carbomer solution was adjusted to 6.3 with arginine.

[0110] The balance is water.

[0111] Specific preparation steps:

[0112] In the first step, carbomer is dissolved in water to prepare a 0.2% mass fraction carbomer solution.

[0113] In the second step, arginine is further added to the carbomer solution to adjust the pH value to 6.3 to obtain a neutralized carbomer solution.

[0114] The third step is to heat the neutralized carbomer solution (pH=6.3) to 75° C., add the oil phase inclusions containing vitamin C, and stir evenly to obtain a water-dispersible preparation.

[0115] Example Description

[0116] Among them, it includes Example Group A, Example Group B, Example Group C, and Example Group D. Specifically, Example Group A is used to explore the influence of different oil thickeners. Example Group B is used to explore the influence of different oils. Example Group C is used to explore the influence of the ratio of the first oil to the second oil. Example Group D is used to explore the influence of the ratio of the oil phase to the oil phase gelling agent.

[0117] (1) Example Group A

[0118] Among them, Example Group A provides an oil phase inclusion body containing vitamin C.

[0119] Specifically, Example Group A includes Example A-1, Example A-2, Example A-3 and Example A-4. The composition of each example included in Example Group A is shown in Table 2 below:

[0120] Table 2 (Composition of ingredients of each example included in Example Group A)

[0121]

[0122]

[0123] The preparation method of the oil phase inclusions containing vitamin C corresponding to Example Group A comprises the following steps:

[0124] In the first step, the oil phase gel and oil are dispersed and swollen uniformly at a preset temperature to obtain a mixture.

[0125] In practice, the preset temperature is 75° C. Specifically, for different embodiments, the oily gel and fat corresponding to the embodiment can be dispersed and swollen evenly to obtain a mixture. For example, for Example A-2, castor oil / IPDI copolymer can be used as an oily gel and the fat can be dispersed and swollen evenly to obtain a mixture.

[0126] In the second step, the inclusion body is added into the above mixture, and the mixture is cooled to room temperature under homogeneous stirring to obtain the oil phase inclusion body.

[0127] In practice, homogenous stirring can be performed at a rotation speed of 12800 rpm.

[0128] The test results of the uniformity of distribution of vitamin C in the oil phase inclusions corresponding to Example Group A are shown in Table 3 below:

[0129] Table 3 (Test results of vitamin C distribution uniformity in oil phase inclusions of Example Group A)

[0130]

[0131] Analysis of Table 3 shows that, after four processes of dissolving, homogenizing, stirring and cooling, the embodiments included in Embodiment Group A can make vitamin C evenly distributed in the sample.

[0132] On the basis of Example Group A, a water dispersion preparation containing oil phase inclusions of vitamin C is further prepared, comprising the following steps:

[0133] In the first step, carbomer is dissolved in water to prepare a 0.2% mass fraction carbomer solution.

[0134] In the second step, arginine was further added to adjust the pH value to 6.3.

[0135] In the third step, after the neutralized carbomer solution (pH = 6.3) is heated to 75°C, the oil phase inclusions containing vitamin C corresponding to Example A-1, Example A-2, Example A-3, and Example A-4 are added and stirred evenly to obtain water-dispersible preparations for Example A-1, Example A-2, Example A-3, and Example A-4, respectively.

[0136] Among them, Figure 1The appearance comparison diagram of the water dispersion preparation corresponding to Example Group A shown, and Figure 2 Another appearance comparison diagram of the water-dispersible preparation corresponding to Example Group A is shown, in which analysis shows that when castor oil / IPDI copolymer, polyethylene wax, and stearic acid dextrin ester are used as oil phase gelling agents, the oil phase cannot wrap vitamin C well, which is manifested as a large amount of vitamin C migrating into the water phase when added to the system, causing the carbogel system to collapse, the viscosity to decrease, and then lose the ability to thicken and suspend. However, the oil phase inclusions made of disteardimethylammonium hectorite can wrap most of the vitamin C therein, preventing a large amount of vitamin C from migrating into the water phase.

[0137] (2) Example Group B

[0138] Among them, Example Group B provides an oil phase inclusion body containing vitamin C.

[0139] Specifically, Example Group B includes Example B-1, Example B-2, Example B-3, Example B-4, Example B-5, Example B-6, and Example B-7. The composition of each example included in Example Group B is shown in Table 4 below:

[0140] Table 4 (Composition of ingredients of each example included in Example Group B)

[0141]

[0142]

[0143] Among them, Example Group B-1 to Example B-7 were respectively subjected to inclusion stability evaluation, water dispersion preparation stability test containing oil phase inclusions of vitamin C, and skin feel evaluation. The test results are shown in Table 5 below:

[0144] Table 5 (Test results of Example Group B-1 to Example B-7)

[0145]

[0146] Analysis of the test results in Table 5 shows that the combination of the first oil and disteardimethylammonium hectorite as the oil phase gelling agent can form an oil phase inclusion body that stably encapsulates vitamin C. The inclusion body can be evenly dispersed in water, but the skin feel and stability need to be improved.

[0147] Further, Example B-8, Example B-9, Example B-10, Example B-11, Example B-12, and Example B-13 are provided. Among them, the mass ratio of the first oil and the oil phase gel in Example B-8 to Example B-13 is 2 to 11:1, and the composition of the ingredients of Example B-8 to Example B-13 is shown in Table 6 below:

[0148] Table 6 (ingredient composition of Example B-8 to Example B-13)

[0149]

[0150] Among them, Examples B-8 to B-13 were respectively subjected to inclusion stability evaluation, water dispersion preparation stability test containing oil phase inclusions of vitamin C, and skin feel evaluation. The test results are shown in Table 7 below:

[0151] Table 7 (Test results of Example B-8 to Example B-13)

[0152]

[0153] By analyzing the test results in Table 7, it can be found that the combination of the first oil and disteardimethylammonium hectorite as the oil phase gelling agent can form an oil phase inclusion body that stably encapsulates vitamin C. Among them, when the first oil is added too little, specifically, see Figure 3 The schematic diagram of the appearance of the water dispersion preparation corresponding to Example B-8 shown in FIG. 1 shows that the oil phase inclusions cannot form a uniform gel state, and the formed oil phase inclusions have a rough appearance and cannot be evenly dispersed. When the first oil is added too much, the specific method can be referred to as Figure 4 The schematic diagram of the appearance of the water dispersion preparation corresponding to Example B-13 shown in FIG. 1 will produce oil leakage, affecting the stability of the oil phase inclusion body.

[0154] Further, Example B-14, Example B-15, Example B-16, Example B-17, Example B-18, and Example B-19 are provided. Among them, the second oil in Example B-14 to Example B-19 is hydrogenated polyisobutylene, and the composition of Example B-14 to Example B-19 is shown in Table 8 below:

[0155] Table 8 (ingredient composition of Example B-14 to Example B-19)

[0156]

[0157]

[0158] Among them, Examples B-14 to B-19 were respectively subjected to inclusion stability evaluation, water dispersion preparation stability test containing oil phase inclusions of vitamin C, and skin feel evaluation. The test results are shown in Table 9 below:

[0159] Table 9 (Test results of Example B-14 to Example B-19)

[0160]

[0161] From the test results of Table 9, it can be found that the combination of the first oil, the second oil and disteardimethylammonium hectorite as the oil phase gelling agent can form an oil phase inclusion that stably encapsulates vitamin C. In addition, vitamin C can be evenly distributed in the oil phase inclusion, and the stability of the water dispersant can be greatly improved, as well as the skin feel, making the skin feel refreshing and easy to absorb.

[0162] Further, Example B-20, Example B-21, Example B-22, Example B-23, and Example B-24 are provided. Among them, the first oil in Example B-20 to Example B-24 is propylene carbonate, and the composition of Example B-20 to Example B-24 is shown in Table 10 below:

[0163] Table 10 (Component composition of Example B-20 to Example B-24)

[0164]

[0165] Among them, Examples B-20 to B-24 were respectively subjected to inclusion stability evaluation, water dispersion preparation stability test containing oil phase inclusions of vitamin C, and skin feel evaluation. The test results are shown in Table 11 below:

[0166] Table 11 (Test results of Example B-20 to Example B-24)

[0167]

[0168] By analyzing the test results of Table 11, it can be found that the combination of the first oil, the second oil and disteardimethyl ammonium hectorite as the oil phase gelling agent can form an oil phase inclusion that stably encapsulates vitamin C, and vitamin C can also be evenly distributed in the oil phase inclusion, and the stability of the water dispersant can be greatly improved, and the skin feel is improved, making the skin feel refreshing and easy to absorb. At the same time, in combination with Example B-24, only the combination of the second oil and disteardimethyl ammonium hectorite as the oil phase gelling agent cannot form an oil phase inclusion that stably encapsulates vitamin C.

[0169] In summary, since the formation state of the microporous structure of disteardimethylammonium hectorite has a strong correlation with the oil used, when the selected oil is properly matched, the high-temperature dispersion process can make the microporous structure of disteardimethylammonium hectorite better formed, and the intuitive effect is that the viscosity of the system is significantly increased and there is no excess oil precipitation.

[0170] (3) Example Group C

[0171] Among them, Example Group C provides an oil phase inclusion containing vitamin C.

[0172] Specifically, Example Group C includes Example C-1, Example C-2, Example C-3, Example C-4, Example C-5, and Example C-6. The content ratios of the first grease and the second grease in the examples included in Example Group C are different. The composition of the ingredients of each example included in Example Group C is shown in Table 12 below:

[0173] Table 12 (Composition of ingredients of Example Group C-1 to Example C-6)

[0174]

[0175] Among them, the mass ratio of propylene carbonate (first oil) to hydrogenated polyisobutylene (second oil) in Example C-1 is 1:0.6, the mass ratio in Example C-2 is 1:1.67; the mass ratio in Example C-3 is 1:1; the mass ratio in Example C-4 is 1:0.14; the mass ratio in Example C-5 is 1:7; and the mass ratio in Example C-6 is 1:0.067.

[0176] Among them, Examples C-1 to C-6 were respectively subjected to inclusion stability evaluation, water dispersion preparation stability test containing oil phase inclusions of vitamin C, and skin feel evaluation. The test results are shown in Table 13 below:

[0177] Table 13 (Test results of Example Group C-1 to Example C-6)

[0178]

[0179] By analyzing the test results in Table 13, it can be found that, especially in Example C-1, Example C-2, Example C-3 and Example C-4, when the mass ratio of the first oil to the second oil is 1:0.1 to 5, an oil phase inclusion that stably encapsulates vitamin C can be formed. Further analysis of Example C-5 shows that when the content of the first oil is low, an oil phase inclusion that encapsulates vitamin C cannot be effectively formed. According to Example C-6, when the content of the first oil is too high, the skin feel deteriorates and the stability is also poor.

[0180] (4) Experimental group D

[0181] Specifically, Example Group D includes Example D-1, Example D-2, Example D-3, Example D-4, Example D-5, and Example D-6. The oils and fats in the examples included in Example Group D include propylene glycol ester and hydrogenated polyisobutylene, and the mass ratio of propylene glycol ester to hydrogenated polyisobutylene is 1:5. The composition of the ingredients of each example included in Example Group D is shown in Table 14 below:

[0182] Table 14 (Composition of ingredients of Example Group D-1 to Example D-6)

[0183]

[0184] Wherein, the mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-1 is 2:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-2 is 4:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-3 is 6:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-4 is 8:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-5 is 10:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-6 is 11:1.

[0185] Among them, Examples D-1 to D-6 were respectively subjected to inclusion stability evaluation, skin feel evaluation, and water dispersion preparation stability test of oil phase inclusions containing vitamin C. The test results are shown in Table 15 below:

[0186] Table 15 (Test results of Example Group D-1 to Example D-6)

[0187]

[0188] By analyzing the test results in Table 15, it can be found that, in particular, Example D-2, Example D-3, Example D-4 and Example D-5 can form oil phase inclusions that stably encapsulate vitamin D. Further analysis of Example D-1 and Example D-6 shows that when the oil content is low, the disteardimethylammonium hectorite cannot be filled with oil, and when the oil content is high, the oil loading capacity of the disteardimethylammonium hectorite is exceeded, resulting in oil leakage.

[0189] Further, Example D-7, Example D-8, Example D-9, Example D-10, Example D-11, and Example D-12 are provided. Among them, the oils in Example Group D-7 to Example D-12 include propylene glycol ester and hydrogenated polyisobutylene, and the mass ratio of propylene glycol ester to hydrogenated polyisobutylene is 1:0.1. The composition of Example D-7 to Example D-12 is shown in Table 16 below:

[0190] Table 16 (Composition of ingredients of Example Group D-7 to Example D-12)

[0191]

[0192] Wherein, the mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-7 is 2:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-8 is 4:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-9 is 6:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-10 is 8:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-11 is 10:1. The mass ratio of fat and oil phase gelling agent (disteardimethylammonium hectorite) in Example D-12 is 11:1.

[0193] Among them, Examples D-7 to D-12 were respectively subjected to inclusion stability evaluation, skin feel evaluation, and water dispersion preparation stability test of oil phase inclusions containing vitamin C. The test results are shown in Table 17 below:

[0194] Table 17 (Test results of Example Group D-7 to Example D-12)

[0195]

[0196] By analyzing the test results in Table 17, it can be found that, in particular, Example D-8, Example D-9, Example D-10 and Example D-11, oil phase inclusions that stably encapsulate vitamin D can be formed. Further analysis of Example D-7 and Example D-12 shows that when the oil content is low, the disteardimethylammonium hectorite cannot be filled with oil, and when the oil content is high, the oil loading capacity of the disteardimethylammonium hectorite is exceeded, resulting in oil leakage.

[0197] Application Examples

[0198] In the application example, an essence containing oil phase inclusions is prepared, wherein the composition of the essence is shown in Table 18 below:

[0199] Table 18 (Composition of ingredients contained in the essence)

[0200]

[0201]

[0202] The steps for preparing the essence are as follows:

[0203] In the first step, the oil phase gel and oil are dispersed and swollen uniformly at a preset temperature to obtain a mixture.

[0204] The preset temperature is 75°C. The oil phase gel is disteardimethylammonium hectorite. The oil comprises: a first oil and a second oil. The first oil is propylene carbonate. The second oil is jojoba oil.

[0205] In the second step, the inclusion body is added into the above mixture, and the mixture is cooled to room temperature under homogeneous stirring to obtain the oil phase inclusion body.

[0206] The third step is to place the ingredients in Table 18 except the oil phase inclusions in a beaker and mix them, keep them warm at 75°C for 20 minutes until they are dissolved and dispersed into a uniform particle-free gel state, and then cool them to 35°C to obtain base material A.

[0207] The fourth step is to add the oil phase inclusions into base material A and stir until uniform particles are formed to obtain an essence containing vitamin C powder inclusions.

[0208] Serum Tests and Reviews

[0209] First of all, the essence has a delicate and uniform appearance, without any excess oil precipitation. At the same time, the essence has evenly suspended oil inclusions. After 30 subjects conducted a skin feel test, the skin feel was refreshing and easy to apply evenly. The overall score was 8.7 points. In addition, the essence has undergone a 180-day stability test, and the test results show that the essence material is stable.

[0210] The above descriptions are only some preferred embodiments of the present disclosure and an explanation of the technical principles used. Those skilled in the art should understand that the scope of the invention involved in the embodiments of the present disclosure is not limited to the technical solutions formed by a specific combination of the above-mentioned technical features, but should also cover other technical solutions formed by any combination of the above-mentioned technical features or their equivalent features without departing from the above-mentioned inventive concept. For example, the above-mentioned features are replaced with the technical features with similar functions disclosed in the embodiments of the present disclosure (but not limited to) and the technical solutions formed.

Claims

1. An oil phase inclusion, comprising: Wrapped objects: 0.5 to 30 parts; Oil, 30-90 parts; Oil phase gel, 0.5-30 parts, Wherein, the encapsulated material is vitamin C and / or vitamin C derivatives, the oil comprises: a first oil, the oil phase gelling agent is disteardimethylammonium hectorite, the first oil is a non-polar oil, and the LogP value of the first oil is ≤7.

5.

2. The oil phase inclusion according to claim 1, wherein The grease further includes: a second grease, wherein the LogP value of the second grease is greater than the logP value of the first grease.

3. The oil phase inclusion according to claim 2, wherein 8≤the logP value of the second oil≤17.

4. The oil phase inclusion according to claim 1, wherein The mass ratio of the oil phase gelling agent to the oil is 1:3-10.

5. The oil phase inclusion according to claim 1, wherein The vitamin C derivatives include: one or more of sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glucoside, 3-o-ethyl ascorbic acid, and ascorbyl tetraisopalmitate.

6. The oil phase inclusion according to claim 1, wherein The first oil comprises: one or more of propylene carbonate, propylene glycol dicaprylate / dicaprate, coconut oil alcohol-caprylate / silicate, dibutyl adipate, isononyl isononanoate, neopentyl glycol di(ethylhexanoate), and pentaerythritol tetra(ethylhexanoate).

7. The oil phase inclusion according to any one of claims 2-3, wherein: The second oil comprises: one or more of hydrogenated polyisobutene, isohexadecane, jojoba oil, squalane, and octyl siloxane.

8. The oil phase inclusion according to claim 1, wherein It also includes one or more of retinol, retinol palmitate, retinol propionate, retinol acetate, ergothioneine, and arbutin.

9. A method for preparing oil phase inclusions, wherein: The method for preparing the oil phase inclusion is used to prepare the oil phase inclusion as claimed in any one of claims 1 to 7, comprising: At a preset temperature, the oil phase gelling agent and the oil are dispersed and swollen uniformly to obtain a mixture; The inclusion body is added into the mixture, and the mixture is stirred homogeneously until it is cooled to room temperature to obtain the oil phase inclusion body.

10. A water-based composition for skin care, wherein: The skin care water formulation composition comprises: The oil phase inclusion according to any one of claims 1 to 7, 1 to 15 parts; Water, 84.2-98.8 parts; Water phase thickener, 0.2 to 0.8 parts.

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