Preparation process of wine-processed propolis Chinese medicinal slices

Abstract

The present invention discloses a preparation process for wine-processed propolis Chinese medicinal slices, comprising the following steps: (1) dissolving and extracting raw propolis with an ethanol-water solution to obtain a propolis liquid; (2) filtering the propolis liquid through a plate-frame filter, recovering ethanol, and collecting a propolis extract; and (3) dripping the propolis extract into a pill-making machine to obtain wine-processed propolis Chinese medicinal slices. The pill-making machine process parameters are as follows: a dripping temperature of 105-135°C, a nozzle temperature of 50-70°C, a coolant temperature of ≤10°C, a dripping distance of 3-6 cm, and dimethyl silicone oil as the coolant. The present invention can effectively solve the problems of coolant residue in the medicinal slices and the problem of the medicinal slices sticking together.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese medicinal pieces, and particularly relates to a preparation process of wine-processed propolis Chinese medicinal pieces. Background Art

[0002] According to the Chinese Pharmacopoeia, propolis is a sticky, solid, colloid-like substance formed by the plant resins collected by worker bees of the family Apis mellifera L., mixed with secretions from their mandibular and wax glands. It is typically collected from beehives in summer and autumn, after impurities are removed. Propolis becomes hard and brittle below 20°C, then softens between 20 and 40°C, becoming sticky and plastic. It should be stored at -4°C. Propolis prepared in wine is a processed form of propolis. The preparation involves crushing the propolis, soaking and dissolving it in ethanol, filtering it, recovering the ethanol from the filtrate, and air-drying it. Propolis and propolis prepared in wine have the effects of tonifying the weak, dissolving turbid fat, and relieving thirst. Externally, it can detoxify, reduce swelling, and promote tissue regeneration. Clinically, it is used for conditions such as premature aging, hyperlipidemia, and diabetes, as well as for external treatment of chapped skin and burns.

[0003] Drop-molding is a common method for preparing wine-processed propolis, resulting in traditional Chinese medicine slices that are easy to consume and store. Unlike commercially available propolis pellets, which often require the addition of a matrix (such as polyethylene glycol) before drop-molding, wine-processed propolis, as a traditional Chinese medicine slice, cannot contain any matrix or other additives, making the molding process more challenging.

[0004] Coolants used in the wine-based propolis droplet molding process (such as dimethyl silicone oil and liquid paraffin) are prone to residue in the propolis slices. Although these coolants are generally food-grade, coolant residue still affects the quality of the slices (such as purity, impact on the release of the slices' medicinal properties, and compatibility). Furthermore, liquid coolant residue in the wine-based propolis slices increases the physical forces between the slices. Combined with the inherent viscosity of propolis, this makes the wine-based propolis slices more likely to stick together. This not only hinders the dispersion of the slices, but also easily sticks to the surface of the equipment, causing slice loss and compromising equipment cleaning.

[0005] Conventional centrifugal drying, currently used in production, can remove some of the coolant remaining on the surface of wine-processed propolis slices to a certain extent. However, propolis is soft at room temperature, and this mechanical method can easily damage the integrity and appearance of the wine-processed propolis slices. Centrifugation at low temperatures can increase the hardness of the propolis, but the coolant becomes more difficult to remove from the surface as its viscosity increases at low temperatures. Small-scale production directly uses cloth, filter paper, or ordinary oil-absorbing paper to manually wipe the coolant off the surface of wine-processed propolis slices. However, these materials often stick to some of the propolis, causing propolis loss, and sometimes damage the wine-processed propolis slices due to personal handling problems.

[0006] In summary, how to provide a preparation process for wine-processed propolis Chinese herbal medicine slices, reduce coolant residues in the slices and prevent the slices from sticking together is an urgent problem to be solved. Summary of the Invention

[0007] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a preparation process for wine-processed propolis Chinese medicinal slices, which can better solve the problems of coolant residue in the slices and the problem of slice adhesion.

[0008] The types of coolant remaining in wine-processed propolis slices can be divided into two types, based on their presence: strongly bound coolant and surface-free coolant. Strongly bound coolant has a strong interaction with the slices, making it difficult to remove, while free coolant has a weaker interaction with the slices and is easier to remove. Therefore, to address the problem of coolant residue in slices, the first step is to reduce the amount of strongly bound coolant remaining in the slices.

[0009] In the molding process of wine-made propolis Chinese herbal medicine slices, when the heated propolis droplets are dripped into the coolant, the huge temperature difference causes the propolis droplets to shrink rapidly. During the shrinkage process, they are easily affected by the process parameters, resulting in uneven shrinkage. The coolant is easily entrained into the interior of the propolis droplets, resulting in a large amount of highly bound coolant remaining in the propolis slices.

[0010] The first purpose of the present invention is to improve the quality of the propolis slices by optimizing the process parameters of propolis drop molding, and at the same time, to control the shrinkage of the propolis droplets when they are dripped into the coolant (dimethyl silicone oil) through the process parameters, thereby effectively reducing the content of the coolant with strong binding properties in the wine-made propolis slices during molding.

[0011] To achieve the first purpose, the technical solution adopted by the present invention is:

[0012] A preparation process of wine-processed propolis Chinese medicinal slices comprises the following steps:

[0013] (1) dissolving and extracting the raw propolis with an ethanol aqueous solution to obtain propolis liquid;

[0014] (2) Filter the propolis liquid through a plate and frame filter, recover the ethanol, collect the propolis extract, and dry it in a vacuum at 50-60°C;

[0015] (3) The propolis product obtained in step (2) is dripped into a pill machine (0.1 g / pill or 0.2 g / pill) to obtain wine-processed propolis Chinese medicinal slices. The process parameters of the pill machine include: dripping temperature of 115-130°C, nozzle temperature of 50-70°C, coolant temperature of 0-6°C, dripping distance (the distance from the dripper to the coolant liquid surface) of 4-5 cm, and the coolant used is dimethyl silicone oil, and the viscosity of the dimethyl silicone oil is 350-750 cSt.

[0016] Preferably, in step (1), the extraction temperature is 40-60°C, the extraction time is 24-48 hours, the volume concentration of the ethanol aqueous solution is 70-95%, and the amount used is 1-6 times the mass of the raw propolis.

[0017] Preferably, in step (2), the relative density of the propolis extract is 1.1-1.3.

[0018] Preferably, in step (3), the dripping speed is 25-35 drops / min, and the amount of coolant used is 15-50 times that of the propolis extract, more preferably 20-30 times.

[0019] The second purpose of the present invention is to replace the higher viscosity (free state) coolant dimethyl silicone oil adhering to the surface of the wine-made propolis slices with low viscosity dimethyl silicone oil, and this low viscosity dimethyl silicone oil is easier to remove.

[0020] To achieve the second purpose, preferably, step (3) includes: using a pill machine to drip the propolis extract into a shape, and washing the obtained propolis product 1-3 times with dimethyl silicone oil having a temperature of 5-10°C and a viscosity of 20-100 cSt, and then filtering to obtain wine-made propolis Chinese medicinal slices. The process parameters of the pill machine include: dripping temperature of 115-130°C, nozzle temperature of 50-70°C, coolant temperature of 0-6°C, dripping distance of 4-5 cm, and the coolant used is dimethyl silicone oil with a viscosity of 350-750 cSt.

[0021] The third purpose of the present invention is to use a specific adsorption material to remove the (free) coolant dimethyl silicone oil adhering to the surface of the wine-made propolis slices without destroying the integrity and appearance of the propolis slices, and can also reduce the adhesion problem between the slices.

[0022] To achieve the third purpose, the technical solution adopted by the present invention is:

[0023] For the above-prepared wine-made propolis Chinese medicinal slices, grapefruit peel material is used to remove the coolant remaining in the slices. The preparation method of the grapefruit peel material comprises the following steps:

[0024] S1. Wash, dry, and sterilize the grapefruit peel, and then crush it into grapefruit peel particles for later use;

[0025] S2. dissolving corn protein in an ethanol-water solution, then adding grapefruit peel particles, stirring evenly and soaking for 3-20 minutes, and then evaporating the solvent (ethanol and water) to obtain treated grapefruit peel particles;

[0026] S3. After boiling the tamarind gum solution for 20-30 minutes, the treated grapefruit peel particles are added and mixed evenly. The particles are then pressed into a sheet at 0.05-0.2 MPa and then dried at 80-90° C. for 1-4 hours to obtain the grapefruit peel material.

[0027] Preferably, in step S1, the particle size of the grapefruit peel particles is 30-100 mesh; in step S2, the mass ratio of corn gluten to grapefruit peel particles is (0.02-0.08):1, the volume concentration of the ethanol aqueous solution is 85-90%, and the amount used is 5-50 times that of corn gluten.

[0028] Preferably, in step S3, the mass ratio of tamarind gum to the processed pomelo peel particles is (0.05-0.1):1, and the mass concentration of the tamarind gum aqueous solution is 10-20 g / L.

[0029] Preferably, the method of using grapefruit peel material to remove coolant residues in the medicinal slices includes: cutting the grapefruit peel material and laying it in a rotatable container (an efficient coating pot can be selected), and then directly introducing the propolis Chinese medicinal slices obtained in the pill machine into the rotatable container, and rotating it at 5-20r / min for 10-20min.

[0030] It is worth noting that in the above content:

[0031] The dimethyl silicone oil, a coolant with strong binding properties in propolis slices, refers to the part of dimethyl silicone oil that has a strong binding effect with the slices, low fluidity, and is not easy to remove by conventional mechanical means (such as centrifugation).

[0032] The free coolant dimethyl silicone oil adhering to the surface of wine-processed propolis slices refers to the part of dimethyl silicone oil that has a weak binding effect with the slices, strong fluidity and freedom, and can be easily removed by conventional mechanical means (such as centrifugation).

[0033] Technical effects of the present invention:

[0034] 1. The preparation process of the wine-processed propolis Chinese medicinal slices of the present invention is simple to operate and can achieve better pill forming without introducing any external substances. The present invention can improve the comprehensive quality of the propolis slices by optimizing the molding process parameters during the preparation of the wine-processed propolis Chinese medicinal slices.

[0035] 2. In the molding process of the wine-processed propolis Chinese medicinal slices of the present invention, the shrinkage of the propolis droplets when the coolant dimethyl silicone oil is added can be further controlled by controlling the molding process parameters (relative density of propolis extract + drop distance + drop temperature + coolant temperature + coolant viscosity), thereby reducing the content of dimethyl silicone oil with strong binding properties in the propolis slices during molding.

[0036] The temperature difference encountered when propolis is dripped into the coolant determines the degree of shrinkage of the droplets, and the dripping distance determines the shape of the propolis droplets when dripping (if the dripping distance is too small, the droplets do not have time to shrink into a circle and start to cool, making the droplets shrink unevenly during cooling; if the dripping distance is too large, the droplets are easily broken and the roundness is not enough, and the shrinkage is also uneven). The relative density of propolis extract and the viscosity of the coolant determine the falling speed of the propolis droplets in the coolant (if the drop is too fast, the propolis is not cooled completely and the droplets shrink too quickly; if the drop is too slow, not only are the droplets easy to stick together, but the droplets also shrink too slowly). When these parameters are appropriate, the propolis droplets can shrink evenly in the coolant, reducing the possibility of the coolant being entrained in the droplets. The content of coolant with strong binding properties in the propolis slices (not easy to remove) can be reduced from the molding process stage, so that most of the coolant on the surface of the propolis slices exists in a free form, which is easier to remove.

[0037] 3. The present invention also uses low-viscosity dimethyl silicone oil to clean propolis after drop molding. Firstly, the low-viscosity dimethyl silicone oil replaces the high-viscosity dimethyl silicone oil used during cooling, which can reduce the content of free dimethyl silicone oil on the surface of propolis slices (low-viscosity dimethyl silicone oil has a relatively low density and is not easy to adhere to the surface of propolis. Moreover, under the same adsorption volume, the weight of the adhered low-viscosity dimethyl silicone oil is less); secondly, the low-viscosity dimethyl silicone oil contained on the surface of propolis is easier to be removed by the subsequent adsorption material - grapefruit peel material.

[0038] 4. The present invention uses grapefruit peel material to remove the coolant dimethyl silicone oil from propolis slices. Specifically, the grapefruit peel material is cut and laid in a rotatable container, and then the propolis slices obtained in the pill machine are directly introduced into the rotatable container, and then the container is rotated at a low speed for treatment. Grapefruit peel is a green and environmentally friendly material with rich pores in its sponge structure, which can effectively absorb and remove dimethyl silicone oil on the surface of the propolis slices without destroying the integrity and roundness of the propolis slices.

[0039] Pure grapefruit peel is not sufficiently hydrophobic and is too soft, making it difficult to stir during the dimethyl silicone oil removal process of propolis slices. Therefore, when preparing the grapefruit peel material, the present invention first treats the grapefruit peel particles with corn gluten before using tamarind gum for bonding. Corn gluten contains a large amount of hydrophobic amino acids, which can form a hydrophobic film on the surface of the grapefruit peel particles. This not only reduces the grapefruit peel's water absorption in the aqueous solution in the subsequent step S3, but also improves the grapefruit peel's adsorption of hydrophobic dimethyl silicone oil. Tamarind gum, a highly viscous polysaccharide, can interact with corn gluten (essentially a protein), improving the compatibility of the tamarind gum binder with the grapefruit peel while also enhancing the tamarind gum's coagulation strength.

[0040] 5. The softness and elasticity of the grapefruit peel material will affect the properties of the propolis slices and the removal of dimethyl silicone oil. When the grapefruit peel material is too soft, it is not conducive to turning the propolis slices during the dimethyl silicone oil removal process, and it is easy for the propolis to adhere to the grapefruit peel material, resulting in propolis loss. When the grapefruit peel material is not soft enough, it is not conducive to the grapefruit peel material absorbing dimethyl silicone oil on the surface of the propolis slices, and it is also easy to damage the appearance of the propolis slices. When the grapefruit peel material is not elastic enough, it is also easy to damage the appearance of the propolis slices. When the grapefruit peel material is too elastic, it is not conducive to the contact between the grapefruit peel material and the propolis pills.

[0041] Therefore, the present invention combines corn protein with tamarind gum to provide appropriate softness and elasticity for the grapefruit peel material, comprehensively improve the removal rate of dimethyl silicone oil, ensure the appearance of propolis slices (mainly roundness) and reduce propolis loss.

[0042] 6. In addition, in the prior art, the removal of dimethyl silicone oil from the surface of propolis slices is likely to cause damage to the surface of the slices. When the surface of the propolis slices is damaged or the roundness is insufficient, the slices are very likely to stick together. The present invention uses grapefruit peel material to perform a relatively gentle treatment on the propolis slices to remove the dimethyl silicone oil, thereby reducing the physical force between the slices caused by the residual liquid coolant dimethyl silicone oil in the wine-made propolis slices, and will not affect the surface integrity and roundness of the slices. Therefore, the propolis slice products treated by the present invention are not prone to adhesion. DETAILED DESCRIPTION

[0043] The above scheme is further described below in conjunction with specific examples; it should be understood that these examples are used to illustrate the basic principles, main features and advantages of the present invention, and the present invention is not limited to the scope of the following examples; the implementation conditions adopted in the examples can be further adjusted according to specific requirements, and the implementation conditions not specified are generally the conditions in routine experiments.

[0044] Unless otherwise specified in the following examples, all raw materials were purchased from commercial sources or prepared by conventional methods in the art. Example 1

[0045] This embodiment provides a preparation process of wine-processed propolis Chinese medicinal slices, comprising the following steps:

[0046] (1) The raw propolis was dissolved and extracted with 2 times the volume of 95% ethanol aqueous solution at a temperature of 50°C and a time of 36 hours to obtain propolis liquid;

[0047] (2) Filter the propolis liquid through a plate-and-frame filter (type 100 plate-and-frame filter), recover the ethanol, collect the propolis extract (relative density of 1.2), and dry it in a vacuum at 55°C;

[0048] (3) The propolis extract was dripped into pills (0.1 g / pill) using a pill machine to obtain wine-processed propolis slices. The process parameters of the pill machine included: dripping temperature of 125°C, nozzle temperature of 60°C, coolant temperature of 3°C, dripping distance (the distance between the dripper and the coolant liquid surface) of 4.5 cm, coolant viscosity of 500 cst, dripping speed of 30 drops / min, and the amount of coolant used was 20 times that of the propolis extract. Example 2

[0049] Based on Example 1, this example provides a preparation process for wine-processed propolis Chinese medicinal slices, comprising the following steps:

[0050] (1) The raw propolis was dissolved and extracted with 2 times the volume of 95% ethanol aqueous solution at a temperature of 50°C and a time of 36 hours to obtain propolis liquid;

[0051] (2) Filter the propolis liquid through a plate and frame filter, recover the ethanol, collect the propolis extract (relative density of 1.2), and dry it in a vacuum at 55°C;

[0052] (3) The propolis extract was dripped into pellets (0.1 g / pill) using a pellet machine. The obtained propolis product was washed twice with dimethyl silicone oil at a temperature of 7°C and a viscosity of 50 cst, and then filtered to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pellet machine included: dripping temperature of 125°C, nozzle temperature of 60°C, coolant temperature of 3°C, dripping distance of 4.5 cm, coolant viscosity of 500 cst, dripping speed of 30 drops / min, and the amount of coolant used was 20 times that of the propolis extract. Example 3

[0053] For the wine-processed propolis Chinese medicinal slices prepared in Example 2, this example uses grapefruit peel material to remove the coolant dimethyl silicone oil remaining in the slices. The preparation method of the grapefruit peel material includes the following steps:

[0054] S1. Wash, dry and sterilize the grapefruit peel, and then crush it into 60-mesh grapefruit peel particles for later use;

[0055] S2. dissolving zein in a 10-fold amount of ethanol-water solution (90% by volume), then adding grapefruit peel particles, stirring evenly, and soaking for 10 minutes. Then, evaporating the solvent (ethanol and water) to obtain treated grapefruit peel particles, wherein the mass ratio of zein to grapefruit peel particles is 0.05:1;

[0056] S3. After boiling a 15 g / L tamarind gum aqueous solution for 25 minutes, the treated grapefruit peel particles were added and mixed evenly. The mixture was then pressed into a sheet at 0.1 MPa and then dried at 85°C for 2 hours to obtain a grapefruit peel material, wherein the mass ratio of tamarind gum to treated grapefruit peel particles was 0.08:1.

[0057] The method of using grapefruit peel material to remove coolant residue in medicinal slices includes: cutting the grapefruit peel material and laying it in a high-efficiency coating pot, then directly introducing the propolis Chinese medicinal slices obtained from the pill machine into the high-efficiency coating pot, and rotating it at 12r / min for 15 minutes. Example 4

[0058] This embodiment provides a preparation process of wine-processed propolis Chinese medicinal slices, comprising the following steps:

[0059] (1) The raw propolis was dissolved and extracted with 3 times the volume of 95% ethanol aqueous solution at a temperature of 40°C and a time of 48 hours to obtain propolis liquid;

[0060] (2) Filter the propolis liquid through a plate and frame filter, recover the ethanol, collect the propolis extract (relative density of 1.1), and dry it in a vacuum at 50°C;

[0061] (3) The propolis extract was dripped into pellets (0.2 g / pill) using a pellet machine. The obtained propolis product was washed once with dimethyl silicone oil at a temperature of 5°C and a viscosity of 20 cst, and then filtered to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pellet machine included: dripping temperature of 115°C, nozzle temperature of 50°C, coolant temperature of 0°C, dripping distance of 4 cm, coolant viscosity of 350 cst, dripping speed of 35 drops / min, and the amount of coolant used was 25 times that of the propolis extract.

[0062] For the above-prepared wine-processed propolis Chinese medicinal slices, this embodiment uses grapefruit peel material to remove the coolant dimethyl silicone oil remaining in the slices. The preparation method of the grapefruit peel material includes the following steps:

[0063] S1. Wash, dry and sterilize the grapefruit peel, and then crush it into 30-mesh grapefruit peel particles for later use;

[0064] S2. dissolving zein in 5 times the amount of ethanol-water solution (volume concentration of 85%), then adding grapefruit peel particles, stirring evenly and soaking for 5 minutes, then evaporating the solvent (ethanol and water) to obtain treated grapefruit peel particles, wherein the mass ratio of zein to grapefruit peel particles is 0.02:1;

[0065] S3. After boiling a 10 g / L tamarind gum aqueous solution for 20 minutes, the treated grapefruit peel particles were added and mixed evenly. The mixture was then pressed into a sheet at 0.05 MPa and dried at 80° C. for 3 hours to obtain a grapefruit peel material, wherein the mass ratio of tamarind gum to the treated grapefruit peel particles was 0.05:1.

[0066] The method of using grapefruit peel material to remove coolant residue in medicinal slices includes: cutting the grapefruit peel material and laying it in a high-efficiency coating pot, then directly introducing the propolis Chinese medicinal slices obtained from the pill machine into the high-efficiency coating pot, and rotating it at 5r / min for 20 minutes. Example 5

[0067] This embodiment provides a preparation process of wine-processed propolis Chinese medicinal slices, comprising the following steps:

[0068] (1) The raw propolis was dissolved and extracted with 6 times the volume of 95% ethanol aqueous solution at a temperature of 60°C and a time of 24 hours to obtain propolis liquid;

[0069] (2) Filter the propolis liquid through a plate and frame filter, recover the ethanol, collect the propolis extract (relative density of 1.3), and dry it in a vacuum at 60°C;

[0070] (3) The propolis extract was dripped into pellets (0.1 g / pill) using a pellet machine. The obtained propolis product was washed three times with dimethyl silicone oil at a temperature of 10°C and a viscosity of 100 cst, and then filtered to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pellet machine included: dripping temperature of 130°C, nozzle temperature of 70°C, coolant temperature of 6°C, dripping distance of 5 cm, coolant viscosity of 750 cst, dripping speed of 25 drops / min, and the amount of coolant used was 30 times that of the propolis extract.

[0071] For the above-prepared wine-processed propolis Chinese medicinal slices, this embodiment uses grapefruit peel material to remove the coolant dimethyl silicone oil remaining in the slices. The preparation method of the grapefruit peel material includes the following steps:

[0072] S1. Wash, dry and sterilize the grapefruit peel, and then crush it into 100-mesh grapefruit peel particles for later use;

[0073] S2. dissolving zein in 20 times the volume of ethanol-water solution (90% by volume concentration), then adding grapefruit peel particles, stirring evenly and soaking for 20 minutes, then evaporating the solvent (ethanol and water) to obtain treated grapefruit peel particles, wherein the mass ratio of zein to grapefruit peel particles is 0.08:1;

[0074] S3. Boil a 20 g / L tamarind gum aqueous solution for 30 minutes, add the treated pomelo peel particles, mix well, and then press into a sheet at 0.2 MPa. Then, dry at 90°C for 1 hour to obtain a pomelo peel material, wherein the mass ratio of tamarind gum to the treated pomelo peel particles is 0.1:1.

[0075] The method of using grapefruit peel material to remove coolant residue in medicinal slices includes: cutting the grapefruit peel material and laying it in a high-efficiency coating pot, then directly introducing the propolis Chinese medicinal slices obtained from the pill machine into the high-efficiency coating pot, and rotating it at 20r / min for 10 minutes.

[0076] Comparative Example 1

[0077] The difference between this comparative example and Example 1 is that in step (2) of the preparation process of wine-processed propolis Chinese medicinal slices, the relative density of the propolis extract is 1.0.

[0078] Comparative Example 2

[0079] The difference between this comparative example and Example 1 is that in step (2) of the preparation process of wine-processed propolis Chinese medicinal slices, the relative density of the propolis extract is 1.4.

[0080] Comparative Example 3

[0081] The difference between this comparative example and Example 1 is that in step (3) of the preparation process of the wine-processed propolis Chinese medicinal slices, the dripping temperature is 110°C.

[0082] Comparative Example 4

[0083] The difference between this comparative example and Example 1 is that in step (3) of the preparation process of the wine-processed propolis Chinese medicinal slices, the dripping temperature is 135°C.

[0084] Comparative Example 5

[0085] The difference between this comparative example and Example 1 is that in step (3) of the preparation process of wine-processed propolis Chinese medicinal slices, the coolant temperature is 8°C.

[0086] Comparative Example 6

[0087] The difference between this comparative example and Example 1 is that in step (3) of the preparation process of wine-processed propolis Chinese medicinal slices, the coolant temperature is -2°C.

[0088] Comparative Example 7

[0089] The difference between this comparative example and Example 1 is that in step (3) of the preparation process of wine-processed propolis Chinese medicinal slices, the dripping distance is 2 cm.

[0090] Comparative Example 8

[0091] The difference between this comparative example and Example 1 is that in step (3) of the preparation process of wine-processed propolis Chinese medicinal slices, the dripping distance is 7 cm.

[0092] Comparative Example 9

[0093] The difference between this comparative example and Example 1 is that in step (3) of the preparation process of the wine-processed propolis Chinese medicinal slices, the viscosity of the coolant is 200 cst.

[0094] Comparative Example 10

[0095] The difference between this comparative example and Example 1 is that in step (3) of the preparation process of the wine-processed propolis Chinese medicinal slices, the viscosity of the coolant is 1000 cst.

[0096] Comparative Example 11

[0097] The difference between this comparative example and Example 2 is that in step (3) of the preparation process of the wine-processed propolis Chinese medicinal slices, the viscosity of the dimethyl silicone oil used for cleaning is 200 cst.

[0098] Comparative Example 12

[0099] The difference between this comparative example and Example 2 is that in step (3) of the preparation process of the wine-processed propolis Chinese medicinal slices, the temperature when using dimethyl silicone oil for cleaning is 3°C.

[0100] Comparative Example 13

[0101] The difference between this comparative example and Example 2 is that in step (3) of the preparation process of the wine-processed propolis Chinese medicinal slices, the temperature when washing with dimethyl silicone oil is 12°C.

[0102] Comparative Example 14

[0103] The difference between this comparative example and Example 3 is that conventional centrifugal drying operation is used to remove the coolant remaining in the slices, the centrifugal speed is 500 r / min, and the centrifugation is carried out for 10 minutes.

[0104] Comparative Example 15

[0105] The difference between this comparative example and Example 3 is that the pomelo peel is washed, dried, and sterilized, and then directly used to remove the coolant remaining in the slices. The coolant removal method is the same as that in Example 7.

[0106] Comparative Example 16

[0107] The difference between this comparative example and Example 3 is that no corn protein is added during the preparation of the pomelo peel material. In this case, the preparation method of the pomelo peel material only includes step S1 and step S3.

[0108] Comparative Example 17

[0109] The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S2, zein is replaced with gelatin.

[0110] Comparative Example 18

[0111] The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S2, the mass ratio of zein to grapefruit peel particles is 0.01:1.

[0112] Comparative Example 19

[0113] The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S2, the mass ratio of zein to grapefruit peel particles is 0.1:1.

[0114] Comparative Example 20

[0115] The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S3, tamarind gum is replaced with gelatin.

[0116] Comparative Example 21

[0117] The difference between this comparative example and Example 3 is that in the pomelo peel material preparation step S3, tamarind gum is replaced with starch.

[0118] Comparative Example 22

[0119] The difference between this comparative example and Example 3 is that in the pomelo peel material preparation step S3, the mass ratio of tamarind gum to the processed pomelo peel particles is 0.03:1.

[0120] Comparative Example 23

[0121] The difference between this comparative example and Example 3 is that in the pomelo peel material preparation step S3, the mass ratio of tamarind gum to the processed pomelo peel particles is 0.12:1.

[0122] 1. Basic tests of the wine-processed propolis Chinese medicinal slices prepared by the present invention

[0123] 1. Quality inspection

[0124] The basic quality test of the wine-processed propolis Chinese medicinal slices prepared in Examples 1-5 of the present invention was carried out with reference to the provisions of the Pharmacopoeia. The results are shown in Table 1.

[0125] Table 1

[0126]

[0127] As shown in Table 1, all quality inspection items of the wine-processed propolis Chinese medicinal slices prepared in Examples 1-5 of the present invention meet the requirements of the Pharmacopoeia, indicating that the preparation process of the present invention can obtain wine-processed propolis Chinese medicinal slices with good overall quality.

[0128] 2. Appearance of medicinal pieces

[0129] The appearance of the wine-processed propolis Chinese medicinal slices prepared in Examples 1-5 of the present invention and Comparative Examples 1-10 was scored, and the scoring standard for each index was: 1 point (poor), 2 points (good), and 3 points (excellent). The results are shown in Table 2.

[0130] Table 2

[0131]

[0132] As shown in Table 2, the appearance scores of the wine-processed propolis slices prepared in Examples 1-5 of the present invention were all high, and all indicators performed well. Comparative Examples 1-10 varied the process parameters of the propolis extract, such as relative density, dripping temperature, coolant temperature, dripping distance, and coolant viscosity, and the appearance scores of the slices decreased.

[0133] 2. Dimethyl silicone oil residue in the wine-processed propolis Chinese medicinal slices prepared by the present invention

[0134] 1. The content of dimethyl silicone oil with strong binding properties of the decoction pieces

[0135] The content of dimethyl silicone oil with strong binding properties in the wine-processed propolis Chinese medicinal slices prepared in Example 1 of the present invention and Comparative Examples 1-10 was measured. The results are shown in Table 3.

[0136] The content of dimethyl silicone oil with strong binding properties in medicinal pieces = total dimethyl silicone oil residue - free dimethyl silicone oil content on the surface of medicinal pieces.

[0137] Among them, the method for determining the total dimethyl silicone oil residue refers to the infrared spectroscopy method (Pharmacopoeia Part IV - Pharmaceutical Excipients - Dimethyl silicone oil - Content Determination), and the method for determining the content of free dimethyl silicone oil on the surface of medicinal pieces is to measure the weight loss after centrifugal drying.

[0138] Table 3

[0139]

[0140] As can be seen from Table 3, compared with Comparative Examples 1-10, the content of dimethyl silicone oil with strong binding properties in the wine-processed propolis Chinese medicinal slices prepared in Example 1 of the present invention is as low as 0.001%, indicating that the preparation process of the medicinal slices of the present invention can reduce the content of dimethyl silicone oil with strong binding properties in the medicinal slices.

[0141] 2. Content of free dimethyl silicone oil on the surface of medicinal pieces

[0142] The content of free dimethyl silicone oil on the surface of the wine-processed propolis Chinese medicinal slices prepared in Examples 1 and 2 of the present invention and Comparative Examples 11-13 was measured. The results are shown in Table 4.

[0143] Table 4

[0144]

[0145] It can be seen from Table 4 that compared with Example 1, after Example 2 of the present invention uses low-viscosity dimethyl silicone oil to clean the medicinal slices, compared with the higher viscosity dimethyl silicone oil used as a coolant, the low-viscosity dimethyl silicone oil is more difficult to adhere to the surface of the medicinal slices and has a lower relative density, thereby effectively reducing the content of free dimethyl silicone oil on the surface of the medicinal slices.

[0146] 3. Effect of the Grapefruit Peel Material of the Present Invention on Removal of Dimethyl Silicone Oil

[0147] 1. Residual dimethyl silicone oil removal rate

[0148] The residual dimethyl silicone oil in the slices was removed according to the methods of Examples 3-5 and Comparative Examples 14-23 of the present invention, and the removal rates of the residual dimethyl silicone oil in the wine-processed propolis slices were respectively measured. The results are shown in Table 5.

[0149] Residual dimethicone removal rate = 100% × (total dimethicone residual amount in the medicinal slices before dimethicone removal - total dimethicone residual amount in the medicinal slices after dimethicone removal) / total dimethicone residual amount in the medicinal slices before dimethicone removal.

[0150] Among them, the method for determining the total dimethicone residue refers to infrared spectroscopy (Pharmacopoeia Part IV - Pharmaceutical Excipients - Dimethicone - Content Determination).

[0151] 2. Adhesion of slices after removing dimethyl silicone oil

[0152] After removing the residual dimethyl silicone oil in the slices according to the methods of Examples 3-5 of the present invention and Comparative Examples 14-23, the adhesion between the slices was observed. The results are shown in Table 5.

[0153] Table 5

[0154]

[0155] As shown in Table 5, the methods of Examples 3-5 of the present invention were used to remove residual dimethyl silicone oil in the medicinal slices, with a removal rate as high as 91.0-91.5%, and there was no adhesion between the medicinal slices.

[0156] Comparative Example 14 used conventional centrifugal drying to remove dimethyl silicone oil. Although its dimethyl silicone oil removal rate was not much different from that of Examples 3-5, severe adhesion occurred between the medicinal pieces. Comparative Example 15 used grapefruit peel to remove dimethyl silicone oil directly. Its removal rate was significantly reduced, and moderate adhesion occurred between the medicinal pieces. Comparative Examples 16-23 changed the preparation method of the grapefruit peel material. As a result, the dimethyl silicone oil removal rate decreased to varying degrees, and the medicinal pieces also had varying degrees of adhesion.

[0157] 3. Appearance and quality loss of medicinal pieces after removing dimethyl silicone oil

[0158] Residual dimethicone in the slices was removed according to the methods of Examples 3-5 of the present invention and Comparative Examples 14-23. The appearance of the slices before and after the removal of dimethicone (including smoothness and roundness, refer to the first item) was scored, and the quality loss of the slices was evaluated by observing the propolis adhered to the surface of the removal material or equipment. The results are shown in Table 6.

[0159] Table 6

[0160]

[0161] As shown in Table 6, when the methods of Examples 3-5 of the present invention were used to remove residual dimethyl silicone oil from the medicinal slices, the appearance of the medicinal slices remained essentially unchanged, and there was no obvious loss in quality.

[0162] Comparative Examples 14 and 15 respectively changed the method of removing dimethicone, and Comparative Examples 16-23 respectively changed the preparation method of grapefruit peel material. As a result, the appearance of the medicinal pieces deteriorated and quality loss occurred to varying degrees.

[0163] 4. Softness and elasticity of the grapefruit peel material of the present invention

[0164] The softness (ie, hardness) and elasticity of the pomelo peel materials prepared in Examples 3-5 and Comparative Examples 15-23 were measured using a texture analyzer. The results are shown in Table 7 below.

[0165] Table 7

[0166]

[0167] As shown in Table 7, the hardness of the grapefruit peel materials prepared in Examples 3-5 of the present invention is in the range of 48-51 N / g, and the elasticity index is in the range of 0.62-0.66. Combined with the results in Tables 5 and 6, it can be seen that when the hardness and elasticity of the grapefruit peel material are within this range, the removal effect of dimethyl silicone oil is better and does not affect the appearance of the medicinal pieces. Therefore, the present invention can improve the removal effect of dimethyl silicone oil by obtaining a grapefruit peel material with appropriate hardness and elasticity. Comparative Example 15 directly uses grapefruit peel raw material, and Comparative Examples 16-23 respectively change the preparation method of the grapefruit peel material, causing the hardness and elasticity of the grapefruit peel material to exceed the appropriate range, and the removal effect of dimethyl silicone oil is also reduced.

[0168] Finally, it should be noted that the above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A preparation process for wine-processed propolis Chinese medicinal slices, characterized in that: The following steps are involved: (1) dissolving and extracting the raw propolis with an ethanol aqueous solution to obtain propolis liquid; (2) Filter the propolis liquid through a plate and frame filter, recover the ethanol, and collect the propolis extract. The relative density of the propolis extract is 1.1-1.3; (3) The propolis extract is dripped into a pill machine, and the obtained propolis product is washed with dimethyl silicone oil at a temperature of 5-10°C and a viscosity of 20-100 cst, and then filtered to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pill machine include: dripping temperature of 115-130°C, nozzle temperature of 50-70°C, coolant temperature of 0-6°C, dripping distance of 4-5 cm, and the coolant used is dimethyl silicone oil with a viscosity of 350-750 cst.

2. The preparation process according to claim 1, wherein: In step (1), the extraction temperature is 40-60°C and the extraction time is 24-48 hours.

3. The preparation process according to claim 1, wherein: In step (3), the dripping speed is 25-35 drops / min, and the amount of coolant used is 15-50 times that of propolis extract.

4. A grapefruit peel material used in the preparation process of the wine-processed propolis Chinese medicinal slices according to claim 1, characterized in that: For the prepared wine-processed propolis Chinese medicinal slices, a grapefruit peel material is used to remove the coolant remaining in the slices. The preparation method of the grapefruit peel material comprises the following steps: S1. Wash, dry, and sterilize the grapefruit peel, and then crush it into grapefruit peel particles for later use; S2. dissolving corn protein in an ethanol aqueous solution, then adding grapefruit peel particles, stirring evenly and soaking for 3-20 minutes, and then evaporating the solvent to obtain treated grapefruit peel particles; S3, boiling the tamarind gum solution for 20-30 minutes, adding the treated grapefruit peel particles, mixing evenly, and then pressing into shape, followed by drying at 80-90° C. for 1-4 hours to obtain the grapefruit peel material; In step S2, the mass ratio of corn gluten to grapefruit peel particles is (0.02-0.08):1, the volume concentration of the ethanol aqueous solution is 85-90%, and the amount used is 5-50 times that of corn gluten; In step S3, the mass ratio of tamarind gum to the processed pomelo peel particles is (0.05-0.1):1, and the mass concentration of the tamarind gum aqueous solution is 10-20 g / L.

5. The pomelo peel material according to claim 4, characterized in that: In step S1, the particle size of the pomelo peel particles is 30-100 mesh.

6. The pomelo peel material according to claim 4, characterized in that: The method of using grapefruit peel material to remove coolant residue in medicinal slices includes: cutting the grapefruit peel material and laying it in a rotatable container, then directly introducing the propolis Chinese medicinal slices obtained from a pill dropping machine into the rotatable container, and rotating it at 5-20r / min for 10-20min.

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