Compound traditional Chinese medicine preparation for treating hepatobiliary diseases and complications thereof and preparation method of compound traditional Chinese medicine preparation

Abstract

The invention discloses a compound traditional Chinese medicine preparation for treating hepatobiliary diseases and complications thereof and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The compound preparation is based on traditional Chinese medicine syndrome differentiation as main symptoms of liver and gallbladder stagnation, liver and gallbladder damp-heat, liver and spleen disharmony and the like, and is prepared by taking the symptoms as methods. The formula is prepared from radix bupleuri, radix paeoniae alba, scutellaria baicalensis, fossil fragments, oysters, endothelium corneum gigeriae galli, scorpions, agastache rugosus, radix aucklandiae, rheum officinale, lotus leaves, turmeric, cicada slough, oriental wormwood, fructus forsythiae, rhizoma phragmitis and the root of kudzu vine through dialectical combination according to According to traditional Chinese medicine syndrome differentiation, liver and gallbladder stagnation, liver and gallbladder damp-heat, liver and spleen disharmony and other syndromes are mainly used. The main symptoms comprise impatience and irritability, dry and bitter mouth, insomnia and dreaminess, chest and hypochondrium pain, irregular stool, red tongue and greasy fur, pulse string and the like. Modern pharmacological research proves that the traditional Chinese medicine composition has the effects of resisting inflammation, benefiting gallbladder, protecting liver cells, regulating immunity and resisting hepatic fibrosis. The traditional Chinese medicine preparation is a pure traditional Chinese medicine preparation, relatively small in side effect and free of obvious adverse reaction after long-time taking.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a compound Chinese medicine preparation for treating hepatobiliary diseases and complications thereof and a preparation method thereof. Background Art

[0002] Hepatobiliary diseases belong to the category of TCM internal medicine. They include: jaundice, flank pain, gallbladder distension, and asthenia. The basic pathogenesis of hepatobiliary diseases is that the liver fails to release and the gallbladder fails to flow. To prevent and treat hepatobiliary diseases, one should avoid strong mental stimulation, strengthen confidence in overcoming the disease, relieve unnecessary worries, and rest in peace; avoid overeating fatty and sweet foods, especially excessive drinking of alcohol, and patients with jaundice and asthenia should abstain from alcohol; salt has the disadvantage of astringency, and patients with asthenia should limit salt intake and be given a low-salt diet. When urine volume decreases, a salt-free diet should be given.

[0003] The liver is located in the right flank, responsible for dredging and discharging, with a strong nature, and likes to be smooth and hates depression. It also stores blood and has the function of storing and regulating blood. It opens the eyes. Common symptoms of liver disease include liver qi stagnation, liver fire inflammation, liver yin deficiency, liver blood deficiency, blood stasis blocking the collaterals, etc. The gallbladder is one of the six internal organs, and it contains the fire of the phase. Because it contains essence and juice, it is also called the extraordinary internal organ. Its qi is smooth when it is unblocked and descending, and it helps the stomach to rot water and grain. Common symptoms of gallbladder disease include gallbladder viscera heat, gallbladder qi stagnation, gallbladder stones, etc. The gallbladder is attached to the liver, and it is the exterior and interior of the liver. The bile duct originates from the liver. Bile is the residual qi of the liver. The foot Jueyin liver meridian and the foot Shaoyang gallbladder meridian are connected, so the pathology of the gallbladder is closely related to the liver. Gallbladder disease can affect the liver, and liver disease can affect the gallbladder. It can cause liver and gallbladder diseases at the same time, and cause liver and gallbladder qi stagnation, liver and gallbladder dampness and heat, etc. Liver and gallbladder symptoms are mostly seen in real syndromes. Liver wood loosens earth, the liver rises with the spleen, and the gallbladder descends with the stomach. The liver wood is born from kidney water and grows in spleen earth. Therefore, liver and gallbladder diseases are closely related to the spleen, stomach, kidney and other internal organs. Clinical symptoms such as liver-spleen disharmony, liver-kidney yin deficiency, and gallbladder and stomach heat stagnation belong to this category.

[0004] Related art discloses a Chinese medicine composition for preventing and treating liver and gallbladder deficiency, which comprises the following components: citron, rose, bergamot, platycodon, lindera striata leaf, tuckahoe, ginseng, perilla, amomum, daidaihua, wolfberry and fennel. The composition is based on liver and gallbladder deficiency caused by abnormal liver and gallbladder system function, and then through the synergistic effect of citron, rose, bergamot, platycodon, lindera striata leaf, tuckahoe, ginseng, perilla, amomum, daidaihua, wolfberry and fennel, it has the functions of promoting qi and relieving pain, relieving swelling and pain, promoting stagnation and relieving swelling, regulating qi and relieving fullness, drying dampness and resolving phlegm, promoting blood circulation, removing blood stasis and generating new blood, smoothing qi and resolving dampness, promoting diuresis and penetrating dampness, promoting diaphragm and descending adverse, warming the middle and dispersing cold, invigorating qi and absorbing blood, and solving the symptoms of liver and gallbladder deficiency; by soothing the liver and regulating qi and relieving fullness, promoting qi and relieving depression, the liver qi is smooth and the dredging is moderate. By producing essence, invigorating qi, nourishing blood, consolidating yin, and softening the liver, the liver and gallbladder qi is full and blood is full, and the yin and yang are balanced. By invigorating the spleen and stomach, warming the kidney and liver, nourishing the spleen and lungs, strengthening the spleen and calming the heart, calming the five internal organs, and harmonizing qi and blood. This prescription is specifically aimed at the symptoms of liver and gallbladder deficiency, and has no therapeutic effect on other symptoms.

[0005] There are many Chinese and Western medicine preparations on the market for the treatment of liver and gallbladder diseases. Although they have certain curative effects, they have several defects: 1. The compatibility of Chinese medicine preparations is relatively simple, and it is difficult to take into account the complex and changeable symptoms of related diseases; 2: Western medicine treatment of liver and gallbladder diseases has a relatively single treatment target, and one drug often cannot adapt to complex clinical symptoms. At the same time, although Western medicine takes effect quickly, it has the disadvantage of large side effects, and long-term use can easily lead to damage to related organs. Summary of the invention

[0006] The first object of the present invention is to provide a compound Chinese medicine preparation for treating hepatobiliary diseases and complications thereof, wherein the compound preparation is mainly based on the syndromes of "liver and gallbladder stagnation", "liver and gallbladder damp-heat", "liver and spleen disharmony" and the like according to TCM syndrome differentiation, and the prescription is prepared according to the syndromes. The prescription is prepared by combining bupleurum, white peony root, scutellaria baicalensis, dragon bone, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, reed root and kudzu root according to the above-mentioned Chinese medicine syndrome differentiation.

[0007] The second purpose of the present invention is to provide a method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications as pills. In this method, crude drug powder is selected and mixed with rice porridge residue and rice soup clear liquid in millet porridge to make pills. Not only the moistening and nourishing properties of millet porridge are utilized, but also millet porridge is used as a binder for the crude drug powder to further promote the preparation of the pills. At the same time, there is no need to use other binders, which avoids the inability of some patients to use the pills.

[0008] The present invention is achieved through the following technical solutions:

[0009] A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications, the preparation being mainly prepared from the following raw materials in parts by weight:

[0010] 10-50 parts of bupleurum, 3-17 parts of white peony root, 3-17 parts of scutellaria, 5-25 parts of dragon bone, 5-25 parts of oyster, 10-50 parts of chicken gizzard lining, 3-17 parts of scorpion, 2-10 parts of patchouli, 2-10 parts of costusroot, 3-17 parts of rhubarb, 2-10 parts of lotus leaf, 2-10 parts of turmeric, 1-5 parts of cicada shell, 10-50 parts of capillaris, 3-17 parts of forsythia, 10-50 parts of reed root and 10-50 parts of kudzu root.

[0011] Traditional Chinese medicine believes that "depression and anger hurt the liver". Negative emotions will first have a major impact on the liver and gallbladder functions, and then affect the functions of other organs. Therefore, in the compound Chinese medicine preparation for treating liver and gallbladder diseases and their complications, Bupleurum, White Peony Root and Scutellaria Baicalensis are used to soothe, clear and soften the liver; "When seeing liver disease, know that the liver will pass it to the spleen, so the spleen should be strengthened first"; the first organs affected by abnormal liver and gallbladder function are the spleen and stomach, and symptoms include abdominal distension, abdominal pain, poor appetite, constipation or diarrhea, so the prescription uses chicken gizzard lining, costus root, kudzu root, lotus leaf and patchouli to regulate qi and strengthen the spleen; liver depression is easy to turn into fire and disturb the mind, and symptoms include dry mouth and bitter taste, pain in the ribs, irritability, insomnia and nightmares, so the prescription uses dragon bone, oyster, artemisia capillaris, forsythia and reed root to clear liver fire, eliminate dampness and heat, and calm the mind; long-term liver depression will lead to qi stagnation and blood stasis, and symptoms include hepatitis, cirrhosis, ascites and even liver cancer, so the prescription uses rhubarb, turmeric, cinnamon twig, cicada shell and scorpion to promote blood circulation and qi circulation to prevent malignant transformation.

[0012] Preferably, the preparation is mainly prepared from the following raw materials in parts by weight:

[0013] 20-40 parts of bupleurum, 7-14 parts of white peony root, 7-14 parts of scutellaria, 10-20 parts of dragon bone, 10-20 parts of oyster, 20-40 parts of chicken gizzard lining, 7-14 parts of scorpion, 4-8 parts of patchouli, 4-8 parts of costusroot, 7-14 parts of rhubarb, 4-8 parts of lotus leaf, 4-8 parts of turmeric, 2-4 parts of cicada shell, 20-40 parts of capillaris, 7-14 parts of forsythia, 20-40 parts of reed root and 20-40 parts of kudzu root.

[0014] Preferably, the preparation is mainly prepared from the following raw materials in parts by weight:

[0015] 25-35 parts of bupleurum, 8-12 parts of white peony root, 8-12 parts of scutellaria, 13-18 parts of dragon bone, 13-18 parts of oyster, 25-35 parts of chicken gizzard lining, 8-12 parts of scorpion, 5-7 parts of patchouli, 5-7 parts of costusroot, 8-12 parts of rhubarb, 5-7 parts of lotus leaf, 5-7 parts of turmeric, 2.5-3.5 parts of cicada shell, 25-35 parts of scutellaria, 8-12 parts of forsythia, 25-35 parts of reed root and 25-35 parts of kudzu root.

[0016] Preferably, the preparation is mainly prepared from the following raw materials in parts by weight:

[0017] 30 parts of bupleurum, 10 parts of white peony root, 10 parts of scutellaria, 15 parts of dragon bones, 15 parts of oysters, 30 parts of chicken's gizzard lining, 10 parts of scorpion, 6 parts of patchouli, 6 parts of costusroot, 10 parts of rhubarb, 6 parts of lotus leaves, 6 parts of turmeric, 3 parts of cicada shells, 30 parts of capillaries, 10 parts of forsythia, 30 parts of reed roots and 30 parts of kudzu roots.

[0018] Bupleurum, a Chinese medicine, is the dried root of Bupleurum chinensie DC. or Bupleurum scorzonerifolium Willd. of the Apiaceae family. It has the effects of relieving fever, soothing the liver and relieving depression, and raising Yang Qi. It is mainly used to treat fever due to superficial symptoms, Shaoyang syndrome, liver depression and qi stagnation, qi deficiency and sinking, organ prolapse, and antipyretic and antimalarial.

[0019] White peony root is a traditional Chinese medicine. It is the root of Paeonia lactiflora Pall., a plant of the genus Paeonia in the family Ranunculaceae. It has the effects of nourishing blood and restraining yin, softening the liver and relieving pain, and calming liver yang. It is mainly used to treat liver blood deficiency, irregular menstruation, liver-spleen disharmony, chest and flank pain, acute pain in the limbs, hyperactivity of liver yang, headache and dizziness, etc.

[0020] Huangqin, a Chinese medicine name. It is the dried root of Scutellaria baicalensis Ceorgi, a plant of the genus Scutellaria in the Lamiaceae family. It has the effects of clearing away heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. It is mainly used to treat damp-heat, summer dampness, chest tightness and nausea, damp-heat fullness, jaundice and diarrhea, lung heat cough, high fever and thirst, blood heat vomiting and epistaxis, and fetal movement disorder.

[0021] Dragon bone, a Chinese medicine name. It is a fossil of bones of ancient large mammals such as elephants, three-toed horses, rhinos, deer, and cattle. It has the effects of calming the nerves, calming the liver and suppressing yang, and consolidating and astringing. It is mainly used to treat restlessness, palpitations and insomnia, epilepsy, vertigo caused by liver yang, slippery symptoms, wet sores, itchy rashes, and long-term sores that do not heal.

[0022] Oyster, a Chinese medicine name. It is the shell of the long oyster Ostrea gigas Thunb., Dalian Bay oyster O.Tallienwhanensisi Crosse or O.rivularis Gould, which belong to the oyster family. It has the effects of calming the liver and suppressing yang, astringing and consolidating, softening and dispersing nodules, and calming the nerves. It is used to treat restlessness, palpitations and insomnia; hyperactivity of liver yang, dizziness; phlegm nodules, goiters, scrofula, accumulation of masses; spontaneous sweating, night sweats, spermatorrhea, spermatorrhea, enuresis, frequent urination, metrorrhagia, leucorrhea and other slippery symptoms; stomachache and acid reflux; lily disease; traumatic bleeding; sores, carbuncles, swellings and eczema.

[0023] Chicken gizzard lining, a Chinese medicine name. It is the inner wall of the gizzard of Gallus gallus domesticus Brisson, a domesticated chicken of the genus Phasianidae. It has the effects of helping digestion and strengthening the stomach, astringing sperm and stopping nocturnal emission. It is mainly used to treat food stagnation, infantile malnutrition, spermatorrhea and enuresis due to kidney deficiency, sandstone stranguria, and gallstones.

[0024] Quanxie, a Chinese medicine name. It is the dried body of the East Asian scorpion Buthus martensii Karsch, a member of the genus Scorpion of the family Scorpionidae. It is mainly distributed in Liaoning, Hebei, Shandong, Anhui, Henan, Hubei and other places. It has the effects of calming wind and relieving spasm, attacking toxins and dispersing knots, unblocking meridians and relieving pain. It is mainly used to treat convulsions, spasms and convulsions caused by various reasons; sores, swellings, scrofula, tuberculosis, gangrene, breast carbuncle; rheumatism, stiffness of tendons and veins; intractable hemiplegia and headache; and it can treat a variety of tumors.

[0025] Patchouli, a Chinese medicine, is the above-ground part of the plant Pogostemon cablin (Blanco) Benth. of the Lamiaceae family. It has the effects of removing dampness, stopping vomiting, and relieving heat. It is mainly used to treat dampness blocking the middle jiao, vomiting, summer dampness or the initial stage of damp-heat.

[0026] Muxiang, a Chinese medicine, is the root of Aucklandia lappa Decne. It has the effects of promoting qi and relieving pain, regulating the middle and removing stagnation. It is mainly used to treat chest and flank distension, abdominal distension and pain, vomiting and diarrhea, and heaviness after diarrhea.

[0027] Rhubarb is a Chinese medicine. It is the root and rhizome of Rheum palmatum L., Rheum tanguticum Maxim.ex Balf. or Rheum officinale Baill. of the Polygonaceae family. It has the effects of purging and attacking accumulation, clearing away heat and purging fire, cooling blood and detoxifying, and removing blood stasis and dredges the menstrual cycle. It is mainly used to treat constipation due to stagnation, vomiting and bleeding due to blood heat, red eyes and swollen throat, heat toxic sores, burns and scalds, blood stasis, damp-heat dysentery, jaundice, and stranguria.

[0028] Lotus leaf, a Chinese medicine name. It is a perennial herbaceous aquatic plant of the genus Nelumbo of the family Nelumbo. Lotus flowers generally grow to 150 cm in height and spread to 3 meters horizontally. The maximum diameter of lotus leaves can reach 60 cm, and the maximum diameter of lotus flowers can reach 20 cm. There are many different varieties of lotus flowers, with flower colors ranging from snow white, yellow to light red, dark yellow and dark red, and other colors such as brocade. It is widely distributed in the north and south. It has the main effects of clearing away heat and relieving summer heat, promoting the clear yang, and dispersing blood stasis and stopping bleeding.

[0029] Turmeric is a Chinese medicine. It is the dried rhizome of Curcuma longa L., a plant of the genus Curcuma in the Zingiberaceae family. It has the effects of promoting blood circulation and qi, relieving pain by menstruation. It is mainly used to treat pain caused by qi stagnation and blood stasis, and rheumatic arthralgia.

[0030] Cicada slough, a Chinese medicine name. It is the skin that falls off when the nymph of Cryptotympana pustulata Fabricius, an insect of the Cicadidae family, sheds its shell when it ecloses. It has the effects of dispersing wind-heat, relieving sore throat and opening voice, clearing rashes, clearing eyes and removing cataracts, and stopping wind and convulsions. It is mainly used to treat wind-heat cold, early stage of febrile disease, sore throat and hoarseness, measles that does not break out, itchy urticaria, red eyes and cataracts, acute and chronic convulsions, tetanus, etc.

[0031] Artemisia capillaris, a Chinese medicine. It is the dried aerial part of Artemisia scoparza Waldst.et Kit. or Artemisia capillaris Thunb. of the Asteraceae family. Those harvested in spring are commonly known as "cotton artemisia", and those harvested in autumn are called "flower artemisia". It has the effects of clearing away dampness and heat, promoting bile and relieving jaundice. It is mainly used to treat jaundice, oliguria, damp-heat and summer-heat, and itching of wet sores.

[0032] Forsythia suspensa (Thunb.) Vahl, a Chinese medicine, is the dried fruit of Forsytnia suspensa (Thunb.) Vahl, a plant of the genus Forsythia in the family Oleaceae. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing knots, and evacuating wind-heat. It is mainly used to treat sores, carbuncle, swelling, scrofula, phlegm nodules, wind-heat exogenous infection, the initial stage of febrile disease, and hot stranguria and pain.

[0033] Reed root, a Chinese medicine name. It is the fresh or dried rhizome of Phragmites communis Trin., a plant of the Gramineae family. It has the effects of clearing away heat and purging fire, promoting body fluid and relieving thirst, relieving restlessness, stopping vomiting, and promoting diuresis. It is mainly used to treat fever and thirst, stomach heat and vomiting, lung heat and cough, lung abscess and vomiting pus, and hot and painful stranguria.

[0034] Pueraria root, a Chinese medicine name. It is the dried root of Pueraria lobata (Willd.) Ohwi, a plant of the genus Pueraria in the Leguminosae family. It is distributed throughout the country except Tibet and Xinjiang. It has the effects of relieving muscle and fever, clearing rashes, promoting body fluid and quenching thirst, and raising yang and stopping diarrhea. It is mainly used to treat fever due to superficial symptoms, stiff neck and back pain, measles that does not clear up, thirst due to febrile diseases, thirst due to yin deficiency, hot diarrhea and dysentery, and diarrhea due to spleen deficiency.

[0035] Preferably, the preparation is a pill for oral administration.

[0036] A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications comprises the following steps:

[0037] S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use;

[0038] S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use;

[0039] S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A;

[0040] S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

[0041] Preferably, the particle size of the raw material powder is 80-100 mesh.

[0042] Preferably, the mass ratio of the raw meal powder to the rice porridge residue is 1.5 to 2:1.

[0043] Preferably, the mixing mass ratio of the raw material powder to the rice soup liquid is 4 to 6:1.

[0044] Preferably, the small pellets are placed for 40 to 48 hours until they expand and enlarge into a mother pellet shape.

[0045] Compared with the prior art, the present invention has at least the following technical effects:

[0046] (I) The present invention provides a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications, wherein the compound preparation is mainly based on the syndromes of "liver and gallbladder stagnation", "liver and gallbladder dampness and heat", "liver and spleen disharmony" and the like according to TCM syndrome differentiation, and the prescription is prepared based on the syndromes. The prescription is prepared by combining Bupleurum, White Peony Root, Scutellaria Baicalensis, Dragon Bone, Oyster, Chicken Gizzard Stone, Scorpion, Patchouli, Aucklandia, Rhubarb, Lotus Leaf, Curcuma Longa, Periostracum Cicadae, Capillaris, Forsythia suspensa, Phragmites australis and Puerariae according to the above TCM syndrome differentiation.

[0047] (II) The compound Chinese medicine preparation is more precise and comprehensive. It can play a major or auxiliary therapeutic role in the current frequent liver and gallbladder-related diseases. Secondly, it follows the core concept of "differentiation and treatment" of traditional Chinese medicine, and is used for various liver and gallbladder diseases and their complications, as well as hypertension, hyperglycemia, dyslipidemia, obesity, etc., with traditional Chinese medicine differentiation as "liver and gallbladder stagnation", "liver and gallbladder dampness and heat", "liver and spleen disharmony" and other syndromes. The main symptoms can be seen as irritability, dry mouth and bitter taste, insomnia, chest and flank pain, irregular bowel movements, red tongue with greasy coating, and stringy pulse.

[0048] (3) Modern pharmacological research has confirmed that the main drugs in this prescription have anti-inflammatory, choleretic, liver cell protective, immune regulatory, and anti-liver fibrosis effects.

[0049] (IV) A method for preparing the compound Chinese medicine preparation for treating hepatobiliary diseases and their complications as pills, wherein the raw drug powder is selected and mixed with rice porridge residue and rice soup clear liquid in millet porridge to make pills, which not only utilizes the moistening and nourishing properties of millet porridge, but also uses millet porridge as a binder for the raw drug powder to further promote the preparation of the pills. At the same time, there is no need to use other binders, thereby avoiding the inability of some patients to use the pills.

[0050] (V) This prescription is a pure Chinese medicine preparation with relatively small side effects and no obvious adverse reactions after long-term use. DETAILED DESCRIPTION

[0051] The embodiments of the present invention will be described in detail below in conjunction with examples. However, those skilled in the art will understand that the following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention. The specific conditions not specified in the examples are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used without indicating the manufacturer are all conventional products that can be purchased commercially.

[0052] Embodiment 1:

[0053] A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications is prepared from the following raw materials in parts by weight:

[0054] 100g of Bupleurum, 30g of White Peony Root, 30g of Scutellaria Baicalensis, 50g of Dragon Bone, 50g of Oyster, 100g of Chicken Gizzard Stone, 30g of Whole Scorpion, 20g of Patchouli, 20g of Costus Root, 30g of Rhubarb, 20g of Lotus Leaf, 20g of Curcuma Longa, 10g of Cicada Periostracum, 100g of Artemisia Capillaris, 30g of Forsythia suspensa, 100g of Phragmites australis and 100g of Pueraria lobata.

[0055] The preparation is a pill for internal use.

[0056] A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications comprises the following steps:

[0057] S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use;

[0058] S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use;

[0059] S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A;

[0060] S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

[0061] The particle size of the raw material powder is 80 meshes.

[0062] The mixing mass ratio of the raw material powder to the rice porridge residue is 1.5:1.

[0063] The mixing mass ratio of the raw material powder to the rice soup clear liquid is 4:1.

[0064] The small pellets are placed for 40 hours until they swell and enlarge into a mother pellet shape.

[0065] Embodiment 2:

[0066] A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications is prepared from the following raw materials in parts by weight:

[0067] 500g of Bupleurum, 170g of White Peony Root, 170g of Scutellaria Baicalensis, 250g of Dragon Bone, 250g of Oyster, 500g of Chicken Gizzard Stone, 170g of Scorpion, 100g of Patchouli, 100g of Costus Root, 170g of Rhubarb, 100g of Lotus Leaf, 100g of Turmeric, 50g of Cicada Periostracum, 500g of Artemisia Capillaris, 170g of Forsythia suspensa, 500g of Phragmites australis and 500g of Pueraria lobata.

[0068] The preparation is a pill for internal use.

[0069] A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications comprises the following steps:

[0070] S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use;

[0071] S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use;

[0072] S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A;

[0073] S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

[0074] The particle size of the raw material powder is 100 meshes.

[0075] The mixing mass ratio of the raw material powder to the rice porridge residue is 2:1.

[0076] The mixing mass ratio of the raw material powder to the rice soup clear liquid is 6:1.

[0077] The small pellets are placed for 48 hours until they swell and enlarge into a mother pellet shape.

[0078] Embodiment 3:

[0079] A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications is prepared from the following raw materials in parts by weight:

[0080] 200g of Bupleurum, 70g of White Peony Root, 70g of Scutellaria Baicalensis, 100g of Dragon Bone, 100g of Oyster, 200g of Chicken Gizzard Stone, 70g of Whole Scorpion, 40g of Patchouli, 40g of Costus Root, 70g of Rhubarb, 40g of Lotus Leaf, 40g of Curcuma Longa, 20g of Cicada Periostracum, 200g of Artemisia Capillaris, 70g of Forsythia suspensa, 200g of Phragmites australis and 200g of Pueraria lobata.

[0081] The preparation is a pill for internal use.

[0082] A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications comprises the following steps:

[0083] S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use;

[0084] S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use;

[0085] S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A;

[0086] S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

[0087] The particle size of the raw material powder is 80 meshes.

[0088] The mixing mass ratio of the raw material powder to the rice porridge residue is 1.5:1.

[0089] The mixing mass ratio of the raw material powder to the rice soup clear liquid is 4:1.

[0090] The small pellets are placed for 40 hours until they swell and enlarge into a mother pellet shape.

[0091] Embodiment 4:

[0092] A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications is prepared from the following raw materials in parts by weight:

[0093] 400g of Bupleurum, 140g of White Peony Root, 140g of Scutellaria Baicalensis, 200g of Dragon Bone, 200g of Oyster, 400g of Chicken Gizzard Stone, 140g of Scorpion, 80g of Patchouli, 80g of Costus Root, 140g of Rhubarb, 80g of Lotus Leaf, 80g of Curcuma Longa, 40g of Cicada Periostracum, 400g of Artemisia Capillaris, 140g of Forsythia suspensa, 400g of Phragmites australis and 400g of Pueraria lobata.

[0094] The preparation is a pill for internal use.

[0095] A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications comprises the following steps:

[0096] S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use;

[0097] S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use;

[0098] S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A;

[0099] S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

[0100] The particle size of the raw material powder is 100 meshes.

[0101] The mixing mass ratio of the raw material powder to the rice porridge residue is 2:1.

[0102] The mixing mass ratio of the raw material powder to the rice soup clear liquid is 6:1.

[0103] The small pellets are placed for 48 hours until they swell and enlarge into a mother pellet shape.

[0104] Embodiment 5:

[0105] A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications is prepared from the following raw materials in parts by weight:

[0106] 250g of Bupleurum, 80g of White Peony, 80g of Scutellaria, 130g of Dragon Bone, 130g of Oyster, 250g of Chicken Gizzard Stone, 80g of Scorpion, 50g of Patchouli, 50g of Costusroot, 80g of Rhubarb, 50g of Lotus Leaf, 50g of Curcuma, 25g of Cicada Periostracum, 250g of Artemisia Capillaris, 80g of Forsythia suspensa, 250g of Phragmites australis and 250g of Pueraria lobata.

[0107] The preparation is a pill for internal use.

[0108] A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications comprises the following steps:

[0109] S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use;

[0110] S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use;

[0111] S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A;

[0112] S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

[0113] The particle size of the raw material powder is 80 meshes.

[0114] The mixing mass ratio of the raw material powder to the rice porridge residue is 1.5:1.

[0115] The mixing mass ratio of the raw material powder to the rice soup clear liquid is 4:1.

[0116] The small pellets are placed for 40 hours until they swell and enlarge into a mother pellet shape.

[0117] Embodiment 6:

[0118] A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications is prepared from the following raw materials in parts by weight:

[0119] 350g of Bupleurum, 120g of White Peony, 120g of Scutellaria, 180g of Dragon Bone, 180g of Oyster, 350g of Chicken Gizzard Stone, 120g of Scorpion, 70g of Patchouli, 70g of Costus, 120g of Rhubarb, 70g of Lotus Leaf, 70g of Curcuma, 35g of Cicada Periostracum, 350g of Artemisia Capillaris, 120g of Forsythia, 350g of Phragmites australis and 350g of Pueraria.

[0120] The preparation is a pill for internal use.

[0121] A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications comprises the following steps:

[0122] S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use;

[0123] S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use;

[0124] S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A;

[0125] S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

[0126] The particle size of the raw material powder is 100 meshes.

[0127] The mixing mass ratio of the raw material powder to the rice porridge residue is 2:1.

[0128] The mixing mass ratio of the raw material powder to the rice soup clear liquid is 6:1.

[0129] The small pellets are placed for 48 hours until they swell and enlarge into a mother pellet shape.

[0130] Embodiment 7:

[0131] A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications is prepared from the following raw materials in parts by weight:

[0132] Bupleurum 30g, white peony 10g, scutellaria 10g, dragon bone 15g, oyster 15g, chicken gizzard 30g, scorpion 10g, patchouli 6g, costusroot 6g, rhubarb 10g, lotus leaf 6g, turmeric 6g, cicada shell 3g, artemisia capillaris 30g, forsythia 10g, reed root 30g and kudzu root 30g.

[0133] The preparation is a pill for internal use.

[0134] A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications comprises the following steps:

[0135] S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use;

[0136] S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use;

[0137] S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A;

[0138] S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

[0139] The particle size of the raw material powder is 100 meshes.

[0140] The mixing mass ratio of the raw material powder to the rice porridge residue is 2:1.

[0141] The mixing mass ratio of the raw material powder to the rice soup clear liquid is 6:1.

[0142] The small pellets are placed for 48 hours until they swell and enlarge into a mother pellet shape.

[0143] Product: Each 100 pills weigh 0.5g, twice a day, 100 pills each time, treatment course: one month.

[0144] Contraindications: Use with caution in patients with weak and cold constitution, with symptoms including fear of cold, cold hands and feet, poor digestion, and loose stools.

[0145] Clinical Cases:

[0146] Case 1: Ma Moumou, male, 31 years old, employee, usually drinks a lot due to social activities. During the physical examination, abnormal transaminase was found, accompanied by fatigue, poor appetite, nausea, insomnia, dark complexion, pale red tongue with white greasy coating, and stringy and smooth pulse. He was advised to drink less and avoid staying up late, and take the pills prepared by the formula of Example 7 orally, 5g each time. One month later, the liver function was checked again and it was normal.

[0147] Case 2: Zhang, male, 50 years old, driver. Due to work-related irregular diet and daily life, he was irritable and irritable, and came to the clinic because of pain in the left flank. Current diagnosis: dull pain in the right flank for one month, accompanied by fatigue, poor appetite, dry and bitter mouth, insomnia and dreaminess, red tongue with white greasy coating, constipation, and a stringy and slippery pulse. Orally take the pills prepared by the formula of Example 7, 5g each time, and the symptoms disappear in half a month.

[0148] Case 3: Wu, female, 28 years old, employee. She complained of obesity (height 162cm, weight 75kg, BMI 28.57), fatigue, dry mouth, drowsiness, irritability, delayed menstruation, loose stools, pale red tongue with white greasy coating, teeth marks on the edges, and a stringy and slippery pulse. The syndrome was liver depression and spleen deficiency, and phlegm and dampness obstruction. Xiaoyao Pills were taken orally with the pills prepared by the formula of Example 7, 5g each time. After one month, the symptoms were alleviated. After taking it for 3 months, the weight dropped to 60kg.

[0149] Case 4: Zhang, female, 75 years old, farmer. Came to the hospital for dry mouth and bitter taste for half a year. Symptoms included dry mouth and bitter taste, especially in the morning, fatigue, poor appetite, abdominal distension, constipation, red tongue with white greasy coating, and stringy and fine pulse. The pills prepared by the formula of Example 7 were taken orally, 5g each time, and dandelion and wormwood decoction was used as tea. After half a month, the dry mouth and bitter taste disappeared, and all symptoms were greatly reduced.

[0150] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the protection scope of the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications, characterized in that: The preparation is mainly prepared from the following raw materials in parts by weight: 10-50 parts of bupleurum, 3-17 parts of white peony root, 3-17 parts of scutellaria, 5-25 parts of dragon bone, 5-25 parts of oyster, 10-50 parts of chicken gizzard lining, 3-17 parts of scorpion, 2-10 parts of patchouli, 2-10 parts of costusroot, 3-17 parts of rhubarb, 2-10 parts of lotus leaf, 2-10 parts of turmeric, 1-5 parts of cicada shell, 10-50 parts of capillaris, 3-17 parts of forsythia, 10-50 parts of reed root and 10-50 parts of kudzu root.

2. A compound Chinese medicine preparation for treating hepatobiliary diseases and their complications according to claim 1, characterized in that: The preparation is mainly prepared from the following raw materials in parts by weight: 20-40 parts of bupleurum, 7-14 parts of white peony root, 7-14 parts of scutellaria, 10-20 parts of dragon bone, 10-20 parts of oyster, 20-40 parts of chicken gizzard lining, 7-14 parts of scorpion, 4-8 parts of patchouli, 4-8 parts of costusroot, 7-14 parts of rhubarb, 4-8 parts of lotus leaf, 4-8 parts of turmeric, 2-4 parts of cicada shell, 20-40 parts of capillaris, 7-14 parts of forsythia, 20-40 parts of reed root and 20-40 parts of kudzu root.

3. A compound Chinese medicine preparation for treating hepatobiliary diseases and complications thereof according to claim 2, characterized in that: The preparation is mainly prepared from the following raw materials in parts by weight: 25-35 parts of bupleurum, 8-12 parts of white peony root, 8-12 parts of scutellaria, 13-18 parts of dragon bone, 13-18 parts of oyster, 25-35 parts of chicken gizzard lining, 8-12 parts of scorpion, 5-7 parts of patchouli, 5-7 parts of costusroot, 8-12 parts of rhubarb, 5-7 parts of lotus leaf, 5-7 parts of turmeric, 2.5-3.5 parts of cicada shell, 25-35 parts of scutellaria, 8-12 parts of forsythia, 25-35 parts of reed root and 25-35 parts of kudzu root.

4. A compound Chinese medicine preparation for treating hepatobiliary diseases and complications thereof according to claim 3, characterized in that: The preparation is mainly prepared from the following raw materials in parts by weight: 30 parts of bupleurum, 10 parts of white peony root, 10 parts of scutellaria, 15 parts of dragon bones, 15 parts of oysters, 30 parts of chicken's gizzard lining, 10 parts of scorpion, 6 parts of patchouli, 6 parts of costusroot, 10 parts of rhubarb, 6 parts of lotus leaves, 6 parts of turmeric, 3 parts of cicada shells, 30 parts of capillaries, 10 parts of forsythia, 30 parts of reed roots and 30 parts of kudzu roots.

5. The compound Chinese medicine preparation for treating hepatobiliary diseases and their complications according to any one of claims 1 to 4, characterized in that: The preparation is a pill for internal use.

6. A method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and their complications as claimed in any one of claims 1 to 4, characterized in that: The steps include: S1. Select radix bupleuri, white peony root, radix scutellariae, keel, oyster, chicken gizzard lining, scorpion, patchouli, costusroot, rhubarb, lotus leaf, turmeric, cicada shell, capillaris, forsythia, rhizoma rehmanniae and kudzu root according to the corresponding mass parts, mix them, grind into powder, filter and sieve to obtain raw material powder for later use; S2, boil millet porridge by conventional method, separate the rice porridge and rice soup clear liquid in the boiled millet porridge, obtain rice soup clear liquid and rice porridge residue separately for standby use; S3, mixing the reserved raw material powder and the rice porridge residue evenly to obtain a reserved material A; S4, start the pill making machine, put the spare material A in the pill making machine, add rice soup liquid in batches to mix and make pills, place the obtained small pellets until they are expanded and enlarged into a masterbatch shape, put them into a polishing machine until the surface is smooth, and sterilize them to obtain.

7. The method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and complications thereof according to claim 6, characterized in that: The particle size of the raw material powder is 80-100 meshes.

8. The method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and complications thereof according to claim 6, characterized in that: The mixing mass ratio of the raw material powder to the rice porridge residue is 1.5 to 2:

1.

9. The method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and complications thereof according to claim 6, characterized in that: The mixing mass ratio of the raw material powder to the rice soup clear liquid is 4 to 6:

1.

10. The method for preparing a compound Chinese medicine preparation for treating hepatobiliary diseases and complications thereof according to claim 6, characterized in that: The small pellets are placed for 40 to 48 hours until they swell and enlarge into a mother pellet shape.