Sanitary pad containing traditional Chinese medicine composition fragrant blasting beads and preparation process of sanitary pad

Abstract

The invention relates to the technical field of nursing pads, in particular to a sanitary pad containing traditional Chinese medicine composition fragrant blasting beads and a preparation process of the sanitary pad. The sanitary pad comprises release paper, a waterproof layer, an absorption layer, a composite layer and release paper from bottom to top, the composite layer is obtained by placing the aroma-condensing blasting beads containing the traditional Chinese medicine composition on the first fabric layer, then covering the second fabric layer and then bonding the aroma-condensing blasting beads and the second fabric layer. The traditional Chinese medicine composition in the sanitary pad can effectively inhibit candida albicans, escherichia coli and staphylococcus aureus; essential oil added in the fragrant condensation beads can provide pleasant fragrance, so that the fragrance of the sanitary pad overflows all around, meanwhile, when the sanitary pad is prepared into a nursing pad, the peculiar smell of the private parts of women can be effectively covered, the antibacterial effect of the sanitary pad can be improved, and lower private part pruritus and peculiar smell conditions can be brought. The sanitary pad can endow the private part of a user with no peculiar smell and no pruritus, and is beneficial to the physiological health of women.

Description

Technical Field

[0001] The invention relates to the technical field of nursing pads, and in particular to a sanitary pad containing Chinese medicine composition fragrant bursting beads and a preparation process thereof. Background Art

[0002] Sanitary pads are disposable sanitary products, mainly used to absorb and keep the private parts clean and dry. They are usually made of PE film, non-woven fabrics, fluff pulp and polymer materials, etc., and are waterproof, soft and have good absorbency.

[0003] At present, it is a trend to use fragrance ingredients and Chinese medicine ingredients in sanitary pads. Such sanitary pads have the effect of promoting a happy mood, and also have the effects of antibacterial, anti-inflammatory, regulating physiological cycles, relieving itching, etc. on the skin or private parts. However, when preparing such sanitary pads, there are certain technical difficulties in adding fragrance ingredients and Chinese medicine ingredients to sanitary pads; and the Chinese medicine composition used has the defect of insufficient efficacy.

[0004] However, there are few sanitary pads containing Chinese medicine composition fragrance bursting beads on the market, and there are few related technical reports. Therefore, a sanitary pad containing Chinese medicine composition fragrance bursting beads is provided to solve the technical problems that fragrance components and Chinese medicine components are not convenient to be added to sanitary pads and the efficacy of Chinese medicine compositions used in sanitary pads is low. Summary of the invention

[0005] The present invention aims at the above technical problems and proposes a technical solution of the present invention, which includes a sanitary pad containing Chinese medicine composition fragrance bursting beads and a preparation process thereof.

[0006] In one aspect, the present invention provides a Chinese medicine composition, the preparation method of which comprises:

[0007] (1) Take 0.5-2 parts of Artemisia annua, 0.2-1.8 parts of Radix Isatidis, 0.2-1.5 parts of Coptis chinensis, and 0.6-2.2 parts of Houttuynia cordata by weight, mix them, and grind them to less than 50 mesh to obtain a grinded product;

[0008] (2) adding 10-40 times the mass of water to the pulverized material, heating to boil, keeping warm at 60-80° C. for 1-4 hours, and then cooling to obtain a cooled product;

[0009] (3) adding 800-1500 U / g of serrapeptase to the cooled product, performing enzymolysis at 50-60° C. for 2-5 hours, inactivating the enzyme, and obtaining an enzymolysis product;

[0010] (4) sterilizing the enzymatic hydrolysis product, adding 1-4% glucose, 0.005-0.1% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, fermenting at 30-40° C. for 60-90 hours, and then sterilizing to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:2-3, and the amount of the fermentation bacteria is (3-8)×10 9 cfu / g enzymatic hydrolysate;

[0011] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 60-75 wt %, stir at 45-60° C. for 4-7 hours, filter, ultrafilter, and dry to obtain the traditional Chinese medicine composition.

[0012] The composition is prepared by hot water extraction, enzymolysis, fermentation and ethanol solution extraction of artemisia annua, isatis root, coptis root and houttuynia cordata. The traditional Chinese medicine composition has excellent antibacterial effect.

[0013] On the other hand, the present invention provides a kind of condensed fragrant bursting beads containing a Chinese medicine composition, and the preparation method thereof comprises: stirring 0.2-0.4 parts of sodium carboxymethyl cellulose and 0.5-1.5 parts of water in parts by mass, adding 1.5-2.5 parts of glycerin and stirring, then adding 0.05-0.5 parts of the above-mentioned Chinese medicine composition and stirring, and then adding 0.1-1 parts of essential oil and stirring to obtain a mixture, and the obtained mixture is loaded with a polyvinyl alcohol film as a wall material to obtain the condensed fragrant bursting beads containing the Chinese medicine composition.

[0014] Preferably, the diameter of the fragrant bursting beads containing the traditional Chinese medicine composition is 5-7 mm, and the thickness of the wall material is 1.3-1.6 mm.

[0015] Wherein, the essential oil comprises at least one of rosemary essential oil, lavender essential oil, citrus essential oil, lemon essential oil and sophora flavescens essential oil.

[0016] The essential oil can provide a pleasant fragrance, so that the product has a good olfactory experience. At the same time, when it is prepared into a nursing pad, it can effectively cover the odor.

[0017] On the other hand, the present invention also provides a sanitary pad containing Chinese medicine composition fragrance bursting beads, which comprises from bottom to top: a release paper, a waterproof layer, an absorption layer, a composite layer and a release paper.

[0018] Preferably, the composite layer is obtained by placing the fragrant bursting beads containing the Chinese medicine composition on the first fabric layer, then covering the second fabric layer, and then bonding them.

[0019] Preferably, the absorption layer contains a highly water-absorbent resin.

[0020] On the other hand, the present invention also provides a method for preparing a sanitary pad containing Chinese medicine composition fragrance bursting beads, comprising the following steps:

[0021] S1: placing the fragrant bursting beads containing the Chinese medicine composition on the first fabric layer, then covering the second fabric layer, and then bonding them to obtain a composite layer;

[0022] S2: Arrange the release paper, the waterproof layer, the absorption layer, the composite layer and the release paper in order from bottom to top, and then bond and punch holes to obtain the sanitary pad containing the Chinese medicine composition fragrance bursting beads.

[0023] Beneficial effects of the present invention:

[0024] The sanitary pad containing Chinese medicine composition fragrance condensing beads provided by the present invention comprises from bottom to top: anti-sticking paper, waterproof layer, absorption layer, composite layer and anti-sticking paper; the composite layer is obtained by placing the Chinese medicine composition fragrance condensing beads on the first fabric layer, then covering the second fabric layer, and then bonding. The Chinese medicine composition in the sanitary pad of the present invention can effectively inhibit Candida albicans, Escherichia coli and Staphylococcus aureus; the essential oil added in the fragrance condensing beads can provide a pleasant fragrance, so that the sanitary pad is full of fragrance. At the same time, when it is prepared into a nursing pad, it can effectively cover the odor of the female genitals, and at the same time, it can also improve the antibacterial effect of the sanitary pad, bringing lower genital itching and odor. The sanitary pad of the present invention can give the user a genitals without odor and itching, which is beneficial to the physiological health of women.

[0025] The composition prepared by the present invention can effectively inhibit Candida albicans. When it is diluted to 20%, the diameter of the inhibited Candida albicans reaches 46.74 mm. It can effectively inhibit and kill Candida albicans, give the sanitary pad an effective defense effect against Candida albicans, and improve the health of the body and the use effect of the sanitary pad.

[0026] The composition prepared by the present invention can effectively inhibit Escherichia coli and Staphylococcus aureus. When it is diluted to 20%, the diameters of the inhibited Escherichia coli and Staphylococcus aureus reach 54.95 mm and 52.13 mm, respectively. The composition can effectively inhibit and kill Escherichia coli and Staphylococcus aureus, and endow the sanitary pad with an effective defense effect against Escherichia coli and Staphylococcus aureus, thereby improving the health of the body and the use effect of the sanitary pad.

[0027] The present invention adopts enzymatic hydrolysis to increase the antibacterial effect of the traditional Chinese medicine composition, and adopts serrapeptase adapted to the composition system of the present invention, which can effectively improve the antibacterial effect of the composition; compared with enzymatic hydrolysis by other enzymes, the antibacterial effect of the composition can be further improved.

[0028] The invention adopts a fermentation method and a solvent extraction method to prepare a traditional Chinese medicine extract to increase the antibacterial effect of the extract. The polymyxa bacillus CI CC 21779 and the thermophilic streptococcus CI CC 6058 are jointly fermented, and the composition obtained by fermenting one of the bacteria has a better effect than that obtained by fermenting one of the bacteria. The joint fermentation of the two can produce a synergistic effect and mutually promote the improvement of the efficacy of the composition. The fermentation ratio of the two will also affect the antibacterial effect of the composition, and the effect is better when the ratio is 1:2-3.

[0029] After fermentation, the present invention uses an alcohol solvent for extraction to further enhance the antibacterial effect of the composition, especially when the ethanol concentration is 60-75%, the antibacterial performance of the obtained composition is better.

[0030] The present invention adds essential oil to the fragrance-exploding gel beads to provide a pleasant fragrance, so that the sanitary pad products have a better olfactory experience. At the same time, when prepared into nursing pads, they can effectively cover the odor of female genitals, and at the same time can also enhance the antibacterial effect of the sanitary pads, resulting in lower genital itching.

[0031] The sanitary pad prepared by the invention contains the fragrance-condensing bursting beads of the traditional Chinese medicine composition, which can make the sanitary pad free of odor and itching for the user, thus being beneficial to the physiological health of women.

[0032] The sanitary pad prepared by the invention has excellent effect and good application prospect. DETAILED DESCRIPTION

[0033] The present invention will be described below in conjunction with specific embodiments, and various effects of the present invention will be more clearly presented. It should be understood by those skilled in the art that these specific embodiments are used to illustrate the present invention, rather than to limit the present invention.

[0034] Paenibacillus polymyxa CI CC 21779 and Streptococcus thermophilus CI CC 6058 were purchased from China Industrial Microbiological Culture Collection Center. Serrapeptase was purchased from Shanxi Zhongnuo Biotechnology Co., Ltd. Bromelain was purchased from Xi'an Musen Bioengineering Co., Ltd.

[0035] 1. Preparation of Chinese medicine composition

[0036] Composition 1:

[0037] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0038] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0039] (3) adding 1100 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0040] (4) Sterilize the enzymatic hydrolysis product, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 37° C. and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:2.5, and the amount of fermentation bacteria is 7.70×10 9 cfu / g enzymatic hydrolysate;

[0041] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 72 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0042] Composition 2:

[0043] The preparation process is as follows: (1) according to the mass parts of the dried product, take 2 parts of Artemisia annua leaves, 0.5 parts of Radix Isatidis, 1.2 parts of Coptis chinensis, and 1 part of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0044] (2) adding 22 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.4 hours, and then cooling to room temperature to obtain a cooled product;

[0045] (3) adding 1000 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.5 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0046] (4) Sterilize the enzymatic hydrolysis product, add 2.4% glucose, 0.05% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 35° C. and 50 rpm for 85 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:2, and the amount of fermentation bacteria is 7.78×10 9 cfu / g enzymatic hydrolysate;

[0047] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 65 wt %, stir at 50° C. and 70 rpm for 5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.69 wt %, to obtain a Chinese medicine composition.

[0048] Composition 3:

[0049] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0050] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0051] (3) The product was cooled and sterilized, and 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria were added to the product, and anaerobically fermented at 37°C and 50 rpm for 82 hours, and then sterilized to obtain a fermentation product; the fermentation bacteria consisted of Bacillus polymyxa CICC 21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:2.5, and the amount of the fermentation bacteria was 7.70×10 9 cfu / g cooling product;

[0052] (4) Add ethanol to the fermentation product to adjust the ethanol concentration to 72 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0053] Composition 4:

[0054] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0055] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0056] (3) adding 1100 U / g bromelain to the cooled product, performing enzymolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymolysis product;

[0057] (4) Sterilize the enzymatic hydrolysis product, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 37° C. and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:2.5, and the amount of fermentation bacteria is 7.70×10 9 cfu / g enzymatic hydrolysate;

[0058] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 72 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0059] Composition 5:

[0060] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0061] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0062] (3) adding 1100 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0063] (4) Add ethanol to the enzymatic hydrolyzate to adjust the ethanol concentration to 72 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0064] Composition 6:

[0065] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0066] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0067] (3) adding 1100 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0068] (4) Sterilize the enzymatic hydrolysis product, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 37°C and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria is Paenibacillus polymyxa CICC21779, and the amount of fermentation bacteria is 7.70×10 9 cfu / g enzymatic hydrolysate;

[0069] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 72 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0070] Composition 7:

[0071] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0072] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0073] (3) adding 1100 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0074] (4) Sterilize the enzymatic hydrolysis product, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 37°C and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria is thermophilic Streptococcus CICC6058, and the amount of fermentation bacteria is 7.70×10 9 cfu / g enzymatic hydrolysate;

[0075] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 72 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0076] Composition 8:

[0077] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0078] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0079] (3) adding 1100 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0080] (4) Sterilize the enzymatic hydrolysis product, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 37° C. and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:0.5, and the amount of fermentation bacteria is 7.70×10 9 cfu / g enzymatic hydrolysate;

[0081] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 72 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0082] Composition 9:

[0083] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0084] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0085] (3) adding 1100 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0086] (4) Sterilize the enzymatic hydrolysis product, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 37° C. and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:6, and the amount of fermentation bacteria is 7.70×10 9 cfu / g enzymatic hydrolysate;

[0087] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 72 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0088] Composition 10:

[0089] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0090] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0091] (3) adding 1100 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0092] (4) Sterilize the enzymatic hydrolysis product, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 37° C. and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:2.5, and the amount of fermentation bacteria is 7.70×10 9 cfu / g enzymatic hydrolysate;

[0093] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 95 wt %, stir at 50 ° C and 70 rpm for 5.5 hours, filter with a 0.5 micron filter membrane, ultrafilter with a throttling molecular weight 1500 Da ultrafiltration membrane, and dry at 70 ° C to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0094] Composition 11:

[0095] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Coptis chinensis, and 2 parts of Houttuynia cordata leaves, mix them, and grind them to less than 50 meshes to obtain a grinded product;

[0096] (2) adding 20 times the mass of water to the pulverized product, heating to boiling, keeping the temperature at 70° C. and 60 rpm for 2.8 hours, and then cooling to room temperature to obtain a cooled product;

[0097] (3) adding 1100 U / g serrapeptase to the cooled product, performing enzymatic hydrolysis at 55° C. for 3.7 hours, inactivating the enzyme, and obtaining an enzymatic hydrolysis product;

[0098] (4) Sterilize the enzymatic hydrolysis product, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, and perform anaerobically fermentation at 37° C. and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:2.5, and the amount of fermentation bacteria is 7.70×10 9 cfu / g enzymatic hydrolysate;

[0099] (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 20 wt %, stir at 50° C. and 70 rpm for 5.5 hours, filter through a 0.5 μm filter membrane, ultrafilter through a 1500 Da ultrafiltration membrane, and dry at 70° C. to a water content of 1.65 wt %, to obtain a Chinese medicine composition.

[0100] 2. Composition Performance Test

[0101] 1. Candida albicans inhibition test: Test the inhibitory effect of the dilution of the above composition on Candida albicans CMCC(F)98001.

[0102] Specific test method: dilute the above composition to a mass concentration of 20% with Tween 60 with a mass concentration of 7% to obtain a sample solution for later use. 6 200 μL of cfu / mL bacterial solution was drawn onto a plate (obtained by pouring YPD medium into a sterile plate and shaking it to solidify), and spread evenly to obtain a bacterial plate. Take a blank drug-sensitive sheet with a diameter of 6.5 mm and a thickness of 0.55 mm, soak it in the above sample solution for 25 minutes, take it out, remove the unabsorbed sample solution, and then place it in the center of the bacterial plate. Incubate at 37°C for 24 hours, and test the diameter of the inhibition zone; each group was tested 4 times in parallel, and the average value was taken. The results of the inhibition test of Candida albicans are shown in Table 1.

[0103] Table 1: Candida albicans inhibition test

[0104] Test / mm Candida albicans Composition 1 46.74 Composition 2 45.98 Composition 3 38.15 Composition 4 43.71 Composition 5 31.94 Composition 6 38.26 Composition 7 39.83 Composition 8 44.12 Composition 9 42.65 Composition 10 39.47 Composition 11 41.39

[0105] 2. Test for inhibition of Escherichia coli and Staphylococcus aureus: Specific test method: Use Tween 60 with a mass concentration of 7% to dilute the above composition to a mass concentration of 20% to obtain a sample solution for standby use. 6200 μL of cfu / mL bacterial solution was drawn onto a plate (obtained by pouring YPD medium into a sterile plate and shaking it to solidify), and spread evenly to obtain a bacterial plate. Take a blank drug-sensitive sheet with a diameter of 6.5 mm and a thickness of 0.55 mm, soak it in the above sample solution for 25 minutes, take it out, remove the unabsorbed sample solution, and then place it in the center of the bacterial plate. Incubate at 37°C for 24 hours, and test the diameter of the inhibition zone; each group was tested 4 times in parallel, and the average value was taken. The results of the inhibition test of Escherichia coli and Staphylococcus aureus are shown in Table 2.

[0106] Table 2: Inhibition test of Escherichia coli and Staphylococcus aureus

[0107] Test / mm Escherichia coli Staphylococcus aureus Composition 1 54.95 52.13 Composition 2 54.03 51.22 Composition 3 44.67 42.45 Composition 4 51.34 48.70 Composition 5 37.26 35.41 Composition 6 44.81 42.56 Composition 7 46.69 44.32 Composition 8 51.83 49.17 Composition 9 50.02 47.54 Composition 10 46.26 43.91 Composition 11 48.58 46.08

[0108] Candida albicans is a common Candida fungus. When the body's defense mechanism is weakened or external factors interfere, Candida albicans may multiply in large numbers and cause infection. Candida albicans infection is mainly manifested by vaginal itching, vulvar redness and swelling, white clot-like secretions, urethral burning, and sexual intercourse pain. Patients with mild symptoms may only experience mild vaginal itching and increased vaginal discharge. Therefore, when providing sanitary pads, it is very necessary for female users to have an effective inhibitory effect on Candida albicans.

[0109] According to the test in Table 1, the composition prepared by the present invention can effectively inhibit Candida albicans. When it is diluted to 20%, the diameter of the inhibited Candida albicans reaches 46.74 mm, which can effectively inhibit and kill Candida albicans, give the sanitary pad an effective defense effect against Candida albicans, and improve the health of the body and the use effect of the sanitary pad.

[0110] Escherichia coli is a Gram-negative bacterium that exists in the intestines of humans and animals. In particular, some specific E. coli can produce toxins, causing food poisoning and severe intestinal diseases. Staphylococcus aureus is a Gram-positive bacterium that may cause skin infections or skin diseases such as boils, abscesses and food poisoning. Therefore, in the textile or sanitary pad industry, E. coli and Staphylococcus aureus are often used as commonly required detection indicators.

[0111] According to the test in Table 2, the composition prepared by the present invention can effectively inhibit Escherichia coli and Staphylococcus aureus. When it is diluted to 20%, the diameters of the inhibited Escherichia coli and Staphylococcus aureus reach 54.95 mm and 52.13 mm, respectively. It can effectively inhibit and kill Escherichia coli and Staphylococcus aureus, and give the sanitary pad an effective defense effect against Escherichia coli and Staphylococcus aureus, thereby improving the health of the body and the use effect of the sanitary pad.

[0112] Using enzymatic hydrolysis to increase the antibacterial effect of traditional Chinese medicine compositions is one of the common research contents at present, and it is particularly important to select suitable enzymes for enzymatic hydrolysis according to different drugs and different types of antibacterial agents. According to the test results of compositions 1 and 3-4 in Table 1-2, it can be seen that the present invention uses serrapeptase to adapt to the composition system of the present invention, which can effectively improve the antibacterial effect of the composition; compared with other enzymes for enzymatic hydrolysis, it can further improve the antibacterial effect of the composition.

[0113] The use of fermentation and solvent extraction to prepare Chinese medicine extracts in order to increase the antibacterial effect of the extracts is one of the research methods in the Chinese medicine industry; and different fermentation bacteria and solvent types and concentrations have different effects on the richness and enrichment of antibacterial active ingredients; therefore, it is necessary to select appropriate bacteria and solvent types and concentrations according to specific goals. The present invention uses polymyxa bacillus CICC 21779 and thermophilic streptococcus CICC 6058 for joint fermentation. Compared with the composition obtained by fermenting one of the bacteria, the joint fermentation of the two can produce a synergistic effect, and mutually promote the efficacy of the composition. The content can be combined with the test results of composition 1, 6-7; and the fermentation ratio of the two will also affect the antibacterial effect of the composition, especially when the ratio is 1:2-3, the effect is better, and the results can be obtained according to the test results of composition 1, 8-9. At the same time, after fermentation, the present invention uses an alcohol solvent for extraction to further enhance the antibacterial effect of the composition, especially when the ethanol concentration is 60-75%, the antibacterial performance of the obtained composition is better, and the results can be obtained based on the test results of compositions 1 and 10-11.

[0114] 3. Sanitary pads and testing

[0115] 1. Sanitary pads

[0116] Sanitary pad 1:

[0117] The preparation method is as follows:

[0118] (1) Preparation of fragrant bursting beads: according to parts by mass, stir 0.3 parts of sodium carboxymethyl cellulose and 0.6 parts of water, add 1.7 parts of glycerin and stir, then add 0.1 parts of the above-prepared composition 1 and stir, and then add 0.2 parts of essential oil (composed of rosemary essential oil, lavender essential oil, and citrus essential oil in a mass ratio of 1:0.5:0.5) and stir to obtain a mixture, and the obtained mixture is loaded with polyvinyl alcohol film as a wall material to obtain fragrant bursting beads with a diameter of about 6 mm and a wall material thickness of about 1.5 mm containing the Chinese medicine composition.

[0119] (2) placing the fragrant bursting beads containing the Chinese medicine composition on the first fabric layer, then covering the second fabric layer, and then bonding them to obtain a composite layer;

[0120] (3) Arrange the release paper, the waterproof layer, the absorbent layer containing the water-absorbing resin, the composite layer and the release paper in order from bottom to top, and then bond and punch holes to obtain the sanitary pad containing the Chinese medicine composition fragrance-condensing beads.

[0121] Sanitary pad 2:

[0122] The preparation method is as follows:

[0123] (1) Preparation of fragrant bursting beads: stir 0.35 parts of sodium carboxymethyl cellulose and 0.7 parts of water according to mass parts, add 1.9 parts of glycerin and stir, then add 0.12 parts of the above-prepared composition 2 and stir, and then add 0.25 parts of essential oil (composed of rosemary essential oil, lavender essential oil, citrus essential oil, lemon essential oil, and Sophora flavescens essential oil in a mass ratio of 1:1:1:1:1) and stir to obtain a mixture, and the obtained mixture is loaded with polyvinyl alcohol film as a wall material to obtain fragrant bursting beads with a diameter of about 6 mm and a wall material thickness of about 1.5 mm containing the Chinese medicine composition.

[0124] (2) placing the fragrant bursting beads containing the Chinese medicine composition on the first fabric layer, then covering the second fabric layer, and then bonding them to obtain a composite layer;

[0125] (3) Arrange the release paper, the waterproof layer, the absorbent layer containing the water-absorbing resin, the composite layer and the release paper in order from bottom to top, and then bond and punch holes to obtain the sanitary pad containing the Chinese medicine composition fragrance-condensing beads.

[0126] Sanitary pad 3: No fragrance in the fragrance beads

[0127] The preparation method is as follows:

[0128] (1) Preparation of fragrant popping beads: Stir 0.3 parts of sodium carboxymethyl cellulose and 0.6 parts of water according to mass parts, add 1.7 parts of glycerin and stir, then add 0.1 parts of the composition 1 prepared above and stir to obtain a mixture, and the obtained mixture is loaded with polyvinyl alcohol film as the wall material to obtain fragrant popping beads with a diameter of about 6 mm and a wall material thickness of about 1.5 mm containing the Chinese medicine composition.

[0129] (2) placing the explosive beads on the first fabric layer, then covering the second fabric layer, and then bonding them to obtain a composite layer;

[0130] (3) Arrange the release paper, the waterproof layer, the absorbent layer containing the water-absorbing resin, the composite layer and the release paper in order from bottom to top, and then bond and punch holes to obtain the sanitary pad containing the Chinese medicine composition fragrance-condensing beads.

[0131] Sanitary pad 4: The difference from sanitary pad 1 is that the composite layer does not use the Chinese medicine composition fragrance-condensing bursting beads, and the rest are the same.

[0132] 2. Testing of sanitary pads

[0133] Twenty healthy female volunteers aged 25-35 were recruited and randomly divided into four groups, with five people in each group. They used the above sanitary pads for three months, and then scored each index, with the highest score of 10 and the lowest score of 0. The test indexes included: odor and degree of vaginal itching. The lower the degree of odor, the higher the score; the lower the degree of vaginal itching, the higher the score. The average score of the specific test results is shown in Table 3.

[0134] Table 3: Sanitary pad test

[0135] test Sanitary pads 1 Sanitary pads 2 Sanitary pads 3 Sanitary pads 4 Odor 9.7 9.7 8.5 8.0 Vaginal itching 9.6 9.7 8.1 7.2

[0136] According to the test of sanitary pads 1-4 in Table 3, it can be seen that the sanitary pads prepared without the aroma-blasting beads or without the use of essential oils have improved the degree of odor and itching in the vulva. It can be seen that the present invention uses essential oils added to the aroma-blasting beads to provide a pleasant fragrance, so that the sanitary pad products have a better olfactory experience. At the same time, when prepared into nursing pads, they can effectively cover the odor of the female vulva, and at the same time, they can also improve the antibacterial effect of the sanitary pads, resulting in lower vulva itching.

[0137] The sanitary pad prepared by the invention contains the fragrance-condensing bursting beads of the traditional Chinese medicine composition, which can make the sanitary pad free of odor and itching for the user, thus being beneficial to the physiological health of women.

[0138] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A sanitary pad containing Chinese medicine composition fragrance bursting beads, characterized in that: It includes, from bottom to top: a release paper, a waterproof layer, an absorption layer, a composite layer and a release paper; The composite layer is obtained by placing the fragrant bursting beads containing the Chinese medicine composition on the first fabric layer, then covering the second fabric layer, and then bonding them.

2. The sanitary pad according to claim 1, characterized in that: The diameter of the fragrant bursting beads containing the traditional Chinese medicine composition is 5-7 mm, and the thickness of the wall material is 1.3-1.6 mm.

3. The sanitary pad according to claim 1, characterized in that: The absorption layer contains highly absorbent resin.

4. A method for preparing a sanitary pad containing Chinese medicine composition fragrance bursting beads according to any one of claims 1 to 3, characterized in that: The steps include: S1: placing the fragrant bursting beads containing the Chinese medicine composition on the first fabric layer, then covering the second fabric layer, and then bonding them to obtain a composite layer; S2: Arrange the release paper, the waterproof layer, the absorption layer, the composite layer and the release paper in order from bottom to top, and then bond and punch holes to obtain the sanitary pad containing the Chinese medicine composition fragrance bursting beads.

5. A method for preparing a Chinese medicine composition, characterized in that: The steps include: (1) Take 0.5-2 parts of Artemisia annua, 0.2-1.8 parts of Radix Isatidis, 0.2-1.5 parts of Coptis chinensis, and 0.6-2.2 parts of Houttuynia cordata by weight, mix them, and grind them to less than 50 mesh to obtain a grinded product; (2) adding 10-40 times the mass of water to the pulverized material, heating to boil, keeping warm at 60-80° C. for 1-4 hours, and then cooling to obtain a cooled product; (3) adding 800-1500 U / g of serrapeptase to the cooled product, performing enzymolysis at 50-60° C. for 2-5 hours, inactivating the enzyme, and obtaining an enzymolysis product; (4) sterilizing the enzymatic hydrolysis product, adding 1-4% glucose, 0.005-0.1% potassium dihydrogen phosphate and fermentation bacteria by weight of the enzymatic hydrolysis product, fermenting at 30-40° C. for 60-90 hours, and then sterilizing to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantitative ratio of 1:2-3, and the amount of the fermentation bacteria is (3-8)×10 9 cfu / g enzymatic hydrolysate; (5) Add ethanol to the fermentation product to adjust the ethanol concentration to 60-75 wt %, stir at 45-60° C. for 4-7 hours, filter, ultrafilter, and dry to obtain the traditional Chinese medicine composition.

6. A Chinese medicine composition prepared by the preparation method according to claim 5.

7. A method for preparing fragrant bursting beads containing a Chinese medicine composition, characterized in that: The method comprises the following steps: stirring 0.2-0.4 parts of sodium carboxymethyl cellulose and 0.5-1.5 parts of water according to parts by mass, adding 1.5-2.5 parts of glycerin and stirring, adding 0.05-0.5 parts of the traditional Chinese medicine composition according to claim 6 and stirring, and then adding 0.1-1 parts of essential oil and stirring to obtain a mixture, and the obtained mixture is loaded with a polyvinyl alcohol film as a wall material to obtain the said aromatic condensed bursting beads containing the traditional Chinese medicine composition.

8. A fragrant bursting bead containing a Chinese medicine composition prepared by the preparation method according to claim 7.

9. The fragrant bursting beads containing a Chinese medicine composition according to claim 8, characterized in that: The diameter of the Chinese medicine composition condensed fragrant bursting beads is 5-7mm, and the thickness of the wall material is 1.3-1.6mm.

10. The fragrant bursting beads containing a Chinese medicine composition according to claim 8, characterized in that: The essential oil includes at least one of rosemary essential oil, lavender essential oil, citrus essential oil, lemon essential oil and sophora flavescens essential oil.