Data monitoring system of glucose sensor

Abstract

The invention particularly relates to a data monitoring system of glucose sensors, which comprises a multi-channel current signal generation module used for controlling a plurality of glucose sensors to detect a plurality of detection samples according to a plurality of sample adding control signals output by a control module and a detection signal output by the control module, obtaining a current signal corresponding to each detection sample; the multi-channel current data processing module is electrically connected with the control module and the multi-channel current signal generation module and is used for converting the plurality of current signals into a plurality of analog voltage signals and converting the plurality of analog voltage signals into a plurality of digital voltage signals; and the control module is electrically connected with the multi-channel current signal generation module and the multi-channel current data processing module, and is used for acquiring a plurality of digital voltage signals and converting the plurality of digital voltage signals into a plurality of digital signals. The problem that a traditional calibration mode brings bad user experience to a patient is avoided.

Description

Technical Field

[0001] The present application belongs to the field of biosensor detection technology, and specifically relates to a data monitoring system for a glucose sensor. Background Art

[0002] Continuous glucose monitoring (CGM) is important for diabetic patients because it enables immediate changes in medication and lifestyle habits during times when glucose levels rise or fall. Through continuous glucose monitoring, glucose levels in interstitial fluid can be detected, which can reflect the current glucose concentration in real time and obtain continuous and comprehensive glucose values, which can facilitate guidance for patients or help doctors guide patients to control glucose.

[0003] Since the CGM system uses a subcutaneously implanted glucose sensor to measure interstitial fluid glucose, the traditional calibration method requires frequent blood glucose measurements (finger pricks) for calibration, which brings a poor user experience to patients, and calibration errors are very likely to occur through frequent blood glucose measurements (finger pricks) for calibration. Summary of the invention

[0004] In order to solve the problem that the prior art requires frequent blood sugar measurement (finger prick) for calibration, which brings a poor user experience to patients, it is necessary to provide a data monitoring system for a glucose sensor to solve the above problems in the prior art.

[0005] The present application provides a data monitoring system for a glucose sensor, the system comprising:

[0006] A multi-channel current signal generating module is electrically connected to the control module, and is used to apply solutions with different glucose concentrations to the multiple glucose sensors to form multiple test samples according to the multiple sample addition control signals output by the control module, and is used to load the multiple glucose sensors to test the multiple test samples according to the excitation signal output by the control module, so as to obtain a current signal corresponding to each test sample;

[0007] A multi-channel current data processing module, electrically connected to the control module and the multi-channel current signal generating module, respectively, for converting a plurality of current signals into a plurality of analog voltage signals, and converting a plurality of analog voltage signals into a plurality of digital voltage signals;

[0008] The control module is electrically connected to the multi-channel current signal generating module and the multi-channel current data processing module respectively, and is used to form a plurality of excitation signals and to convert the plurality of current signals into a plurality of digital signals.

[0009] In one embodiment, the multi-channel current signal generating module includes a signal excitation submodule and a sample addition submodule, the signal excitation submodule and the sample addition submodule are electrically connected to the control module respectively, and the signal excitation submodule and the sample addition submodule are connected through a pipeline; wherein the sample addition submodule is used to apply solutions with different glucose concentrations to form multiple detection samples according to multiple sample addition control signals output by the control module; the signal excitation submodule is used to control multiple glucose sensors to detect multiple detection samples according to the detection signal of the control module, and obtain a current signal corresponding to each detection sample.

[0010] In one embodiment, the loading submodule includes an automatic loading unit and a constant temperature water bath, wherein the automatic loading unit is electrically connected to the control module and is connected to the constant temperature water bath unit through a pipeline; wherein the automatic loading unit is used to input glucose of a concentration corresponding to each loading control signal output by the control module into the constant temperature water bath through a pipeline; the constant temperature water bath is used to load glucose solutions of different concentrations and control them to a target temperature to form multiple detection samples of the target temperature, and transmit the multiple target detection samples to the signal excitation submodule.

[0011] In one embodiment, the signal excitation submodule includes multiple glucose sensors and a multi-channel excitation unit, the multi-channel excitation unit is electrically connected to the control module and the multiple glucose sensors respectively, each glucose sensor is electrically connected to the multi-channel current data processing module, and is connected to the loading submodule; wherein the multi-channel excitation unit is used to load the multiple glucose sensors according to the excitation signal output by the control module; each glucose sensor is used to receive the bias voltage signal loaded by the multi-channel excitation unit, form multiple samples of glucose solutions with different concentrations for detection, and transmit the detected current signal to the multi-channel current data processing module.

[0012] In one embodiment, the multi-channel current data processing module includes a multi-channel isolated current detection unit and a multi-channel synchronous analog-to-digital conversion unit, and the multi-channel isolated current detection unit is electrically connected to the multi-channel synchronous analog-to-digital conversion module and multiple glucose sensors respectively, and the multi-channel synchronous analog-to-digital conversion module is also electrically connected to the control module; wherein the multi-channel isolated current detection unit is used to obtain current signals of multiple glucose sensors and convert the multiple current signals into multiple analog voltage signals; the multi-channel synchronous analog-to-digital conversion unit is used to convert multiple analog voltage signals into multiple digital voltage signals and transmit the multiple digital voltage signals to the control module.

[0013] In one of the embodiments, the multi-channel current data processing module further includes: a multi-channel filtering circuit electrically connected between the multi-channel isolated current detection unit and the multi-channel synchronous analog-to-digital conversion unit, and used to filter each analog voltage signal output by the multi-channel isolated current detection unit.

[0014] In one of the embodiments, the system further includes: a host computer electrically connected to the control module, for acquiring a plurality of digital signals output by the control module, and for determining a current variation curve according to the plurality of digital signals.

[0015] In one embodiment, the multi-channel excitation unit includes a DAC chip and multiple excitation circuits, each excitation circuit includes a first operational amplifier and a second operational amplifier, and the DAC chip includes multiple reference voltage output pins; wherein the non-inverting input terminal of the first operational amplifier is connected to a reference voltage output pin of the DAC chip, the reverse input terminal of the first operational amplifier is electrically connected to a first electrode connection point of a glucose sensor, the reverse input terminal of the second operational amplifier is electrically connected to another reference voltage output pin of the DAC chip, the non-inverting input terminal of the second operational amplifier is electrically connected to a reference electrode connection point of a glucose sensor, and the output terminal of the second operational amplifier is connected to a second electrode connection point of a glucose sensor.

[0016] In one embodiment, the multi-channel isolated current detection unit includes multiple isolated current detection circuits, each of which includes a transimpedance amplifier, a third operational amplifier, a fourth operational amplifier, a linear isolator, a first resistor, a second resistor, a third resistor, a feedback resistor and a feedback capacitor; wherein the same-direction input terminal of the transimpedance amplifier is connected to the current output terminal of a glucose sensor, the output terminal of the transimpedance amplifier is respectively connected to one end of the first resistor and one end of the feedback resistor, the other end of the feedback resistor is connected to the reverse input terminal of the transimpedance amplifier, one end of the feedback capacitor is connected to one end of the feedback resistor, the other end of the feedback capacitor is connected to the other end of the feedback resistor, and the other end of the first resistor is connected to the reverse input terminal of the third amplifier. The non-inverting input terminal of the third amplifier is connected to ground, the output terminal of the third amplifier is connected to one end of the second resistor, the other end of the second resistor is connected to the first input terminal of the linear isolator, the second input terminal of the linear isolator is connected to the first power supply, the third input terminal of the linear isolator is connected to the inverting input terminal of the third amplifier, the fourth input terminal of the linear isolator is grounded, the first output terminal of the linear isolator is grounded, the second output terminal of the linear isolator is connected to the inverting input terminal of the fourth amplifier, the non-inverting input terminal of the fourth amplifier is grounded, the output terminal of the fourth amplifier outputs an analog voltage signal, one end of the third resistor is connected to the output terminal of the fourth amplifier, and the other end of the third resistor is connected to the inverting input terminal of the fourth amplifier.

[0017] In one embodiment, the constant temperature water bath further comprises a plurality of fixed connection devices, each of which is used to immerse a glucose sensor in the constant temperature water bath device, and the two-sided clamps of each fixed connection device comprise a plurality of ejector pins, each of which is connected in turn to a plurality of electrode contacts of the glucose sensor, and the plurality of electrode contacts are led out through a plurality of wires.

[0018] The data monitoring system for the glucose sensor proposed in the present application can at least control the multi-channel current signal generating module and the multi-channel current data processing module through the control module to detect large quantities of glucose sensors, and the detection channels of each glucose sensor do not interfere with each other. It is easy to operate and has a high degree of automation, avoiding the traditional calibration method that requires frequent blood sugar measurement (finger prick) for calibration, which brings patients a poor user experience and easy calibration error problems.

[0019] Furthermore, the data monitoring system for the glucose sensor proposed in the present application can also meet the requirements of characterizing the sensitivity of the glucose sensor and is conducive to ensuring the batch production of sensors with low variability. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, drawings of other embodiments can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 A schematic diagram of a data monitoring system for a glucose sensor provided in one embodiment of the present application;

[0022] Figure 2 A schematic diagram of another data monitoring system for a glucose sensor provided in an embodiment of the present application;

[0023] Figure 3 A circuit diagram of a multi-channel excitation unit provided in an embodiment of the present application;

[0024] Figure 4 1 is a circuit diagram of a multi-channel isolated current detection unit provided in an embodiment of the present application.

[0025] Explanation of the accompanying drawings: 101, control module; 102, multi-channel current signal generating module; 103, multi-channel current data processing module; 209, sample adding submodule; 210, signal excitation submodule; 208, host computer; 203, constant temperature water bath; 204, automatic sample adding unit; 201, multiple glucose sensors; 202, multi-channel excitation unit; 205, multi-channel isolated current detection unit; 206, multi-channel synchronous analog-to-digital conversion unit; 207, multi-channel filtering circuit; 301, DAC chip; 302, glucose sensor; U1, first operational amplifier; U2, second operational amplifier; U3, third operational amplifier; U4, fourth operational amplifier; TIA, transimpedance amplifier; WE1, first electrode connection point; RE1, reference electrode connection point; CE1, second electrode connection point; 401, linear isolator; R1, first resistor; R2, second resistor; R3, third resistor; Rf, feedback resistor; Cf, feedback capacitor. DETAILED DESCRIPTION

[0026] In order to facilitate understanding of the present application, the present application will be described more fully below with reference to the relevant drawings. Embodiments of the present application are provided in the drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0027] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0028] It is understood that the terms "first", "second", "third", "fourth", etc. used in this application may be used herein to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish a first element from another element. For example, without departing from the scope of this application, a first control device may be referred to as a second control device, and similarly, a second control device may be referred to as a first control device. Both the first control device and the second control device are control devices, but they are not the same control device.

[0029] It can be understood that the “connection” in the following embodiments should be understood as “electrical connection”, “communication connection”, etc. if the connected circuits, modules, units, etc. have electrical signals or data transmission between each other.

[0030] When used herein, the singular forms "a", "an", and "said / the" may also include plural forms, unless the context clearly indicates otherwise. It should also be understood that the terms "include / comprise" or "have" and the like specify the presence of stated features, wholes, steps, operations, components, parts, or combinations thereof, but do not exclude the possibility of the presence or addition of one or more other features, wholes, steps, operations, components, parts, or combinations thereof. At the same time, the term "and / or" used in this specification includes any and all combinations of the relevant listed items.

[0031] Continuous glucose monitoring (CGM) is important for diabetic patients because it enables immediate changes in medication and lifestyle habits during times when glucose levels rise or fall. Through continuous glucose monitoring, glucose levels in interstitial fluid can be detected, which can reflect the current glucose concentration in real time and obtain continuous and comprehensive glucose values, which can facilitate guidance for patients or help doctors guide patients to control glucose.

[0032] Since the CGM system uses a subcutaneously implanted glucose sensor to measure interstitial fluid glucose, the traditional calibration method requires frequent blood sugar measurements (finger pricks) for calibration, which brings a poor user experience to patients.

[0033] See also Figure 1 The present application provides a data monitoring system for a glucose sensor. The data monitoring system includes: a multi-channel current signal generating module 102 , a multi-channel current data processing module 103 and a control module 101 .

[0034] Specifically, the multi-channel current signal generating module 102 is electrically connected to the control module 101, and is used to apply solutions of different glucose concentrations to multiple glucose sensors to form multiple detection samples according to multiple sample addition control signals output by the control module 101, and is used to load multiple glucose sensors to detect multiple detection samples according to the excitation signal output by the control module 101, so as to obtain a current signal corresponding to each detection sample.

[0035] Specifically, the multi-channel current data processing module 103 is electrically connected to the control module 101 and the multi-channel current signal generating module 102, respectively, and is used to convert multiple current signals into multiple analog voltage signals, and convert multiple analog voltage signals into multiple digital voltage signals.

[0036] Specifically, the control module 101 is electrically connected to the multi-channel current signal generating module 102 and the multi-channel current data processing module 103, respectively, and is used to form a plurality of excitation signals and to convert the plurality of current signals into a plurality of digital signals.

[0037] As an example, see Figure 2 , the present application provides a data monitoring system for a glucose sensor. Figure 2 As shown in , the multi-channel current signal generating module 102 includes a signal excitation submodule 210 and a charging submodule 209, which are electrically connected to the control module 101 respectively, and the signal excitation submodule 210 and the charging submodule 209 are connected through pipelines.

[0038] The sample adding module 209 is used to apply solutions with different glucose concentrations to form multiple test samples according to multiple sample adding control signals output by the control module 101.

[0039] The signal excitation submodule 210 is used to control the multiple glucose sensors 201 to detect multiple detection samples according to the detection signal of the control module 101, and obtain a current signal corresponding to each detection sample.

[0040] like Figure 2 As shown in FIG. 1 , the sample loading module 209 includes an automatic sample loading unit 204 and a constant temperature water bath 203 . The automatic sample loading unit 204 is electrically connected to the control module 101 and is connected to the constant temperature water bath 203 through a pipeline.

[0041] Among them, the automatic loading unit 204 is used to input glucose of a concentration corresponding to each loading control signal output by the control module into the constant temperature water bath 203 through a pipeline; the constant temperature water bath 203 is used to load glucose solutions of different concentrations and control them to a target temperature to form multiple detection samples of the target temperature, and transmit the multiple target detection samples to the signal excitation submodule 210.

[0042] like Figure 2 As shown in the figure, the signal excitation submodule 210 includes multiple glucose sensors 201 and a multi-channel excitation unit 202. The multi-channel excitation unit 202 is electrically connected to the control module 101 and the multiple glucose sensors 201 respectively. Each glucose sensor is electrically connected to the multi-channel current data processing module 103 and is connected to the addition module 209 through a pipeline.

[0043] Among them, the multi-channel excitation unit 202 is used to load multiple glucose sensors 201 according to the excitation signal output by the control module; each glucose sensor is used to receive the bias voltage signal loaded by the multi-channel excitation unit, form multiple samples of glucose solutions with different concentrations for detection, and transmit the detected current signal to the multi-channel current data processing module 103.

[0044] like Figure 2 As shown in the figure, the multi-channel current data processing module 103 includes a multi-channel isolated current detection unit 205 and a multi-channel synchronous analog-to-digital conversion unit 206. The multi-channel isolated current detection unit 205 is electrically connected to the multi-channel synchronous analog-to-digital conversion module and multiple glucose sensors 201 respectively, and the multi-channel synchronous analog-to-digital conversion module is also electrically connected to the control module.

[0045] Among them, the multi-channel isolated current detection unit 205 is used to obtain the current signals of multiple glucose sensors 201 and convert the multiple current signals into multiple analog voltage signals; the multi-channel synchronous analog-to-digital conversion unit 206 is used to convert the multiple analog voltage signals into multiple digital voltage signals and transmit the multiple digital voltage signals to the control module.

[0046] like Figure 2 As shown in the figure, the multi-channel current data processing module 103 also includes: a multi-channel filtering circuit 207, which is electrically connected between the multi-channel isolated current detection unit 205 and the multi-channel synchronous analog-to-digital conversion unit 206, and is used to filter each analog voltage signal output by the multi-channel isolated current detection unit 205.

[0047] like Figure 2 As shown in , the system further includes: a host computer 208, which is electrically connected to the control module 101, and is used to obtain a plurality of digital signals output by the control module 101, and is used to determine a current variation curve according to the plurality of digital signals.

[0048] In one embodiment, the constant temperature water bath 203 further includes a plurality of fixed connection devices, each of which is used to immerse a glucose sensor in the constant temperature water bath device, and the two-sided clamps of each fixed connection device include a plurality of ejector pins, each of which is connected in turn to a plurality of electrode contacts of the glucose sensor, and the plurality of electrode contacts are led out through a plurality of wires.

[0049] Exemplarily, the control module 101 includes data calculation and processing, data transmission and switch output units. The digital voltage signal transmitted by the multi-channel synchronous analog-to-digital conversion unit 206 is converted into a current signal by the data calculation and processing unit, and the current data is sent to the host computer 208 software through the data transmission unit. The switch output unit controls the switch of the automatic sampling unit 204.

[0050] The automatic adding unit 204 can use a pump to add different glucose concentrations to the constant temperature water bath and the fixed connection device. The adding interval time and the adding amount are controlled by the control module 101 to meet the automated operation process.

[0051] As an example, see Figure 3 The present application provides a circuit diagram of a multi-channel excitation unit 202. The multi-channel excitation unit 202 includes a DAC chip 301 and a plurality of excitation circuits, each of which includes a first operational amplifier U1 and a second operational amplifier U2, and the DAC chip 301 includes a plurality of reference voltage output pins.

[0052] Among them, the non-inverting input terminal of the first operational amplifier U1 is connected to a reference voltage output pin of the DAC chip 301, the reverse input terminal of the first operational amplifier U1 is electrically connected to the first electrode connection point WE1 of a glucose sensor, the reverse input terminal of the second operational amplifier U2 is electrically connected to another reference voltage output pin of the DAC chip 301, the non-inverting input terminal of the second operational amplifier U2 is electrically connected to the reference electrode connection point RE1 of a glucose sensor, and the output terminal of the second operational amplifier U2 is connected to the second electrode connection point CE1 of a glucose sensor.

[0053] Here, the DAC chip 301 can be a high-precision, self-calibrated multi-output DAC chip 301, which uses serial SPI communication, supports cascading of multiple DAC chips 301, and outputs DAC1, DAC2 and multiple voltages as voltage reference sources, and its output voltage values ​​are adjustable.

[0054] Here, the operational amplifier of the multi-channel excitation unit 202 adopts a dual-channel precision amplifier (the first operational amplifier U1 and the second operational amplifier U2) with low bias current. By utilizing the characteristics of the operational amplifier, the bias voltage difference formed by DAC1 and DAC2 is loaded as an excitation source on the working electrode and the reference electrode of the glucose sensor 302. The value of the bias voltage is adjustable. The method of loading the excitation source for multiple glucose sensors 201 is as follows: Figure 3 The glucose sensor loading method in is implemented and will not be described in detail here.

[0055] As an example, see Figure 4 , the present application provides a circuit diagram of a single-channel isolation current detection unit. The multi-channel isolation current detection unit 205 includes a plurality of isolation current detection circuits, each of which includes a transimpedance amplifier TIA, a third operational amplifier U3, a fourth operational amplifier U4, a linear isolator 401, a first resistor R1, a second resistor R2, a third resistor R3, a feedback resistor Rf, and a feedback capacitor Cf.

[0056] Specifically, the non-inverting input terminal of the transimpedance amplifier TIA is connected to the current output terminal of a glucose sensor, the output terminal of the transimpedance amplifier TIA is respectively connected to one end of the first resistor R1 and one end of the feedback resistor Rf, the other end of the feedback resistor Rf is connected to the reverse input terminal of the transimpedance amplifier TIA, one end of the feedback capacitor Cf is connected to one end of the feedback resistor Rf, the other end of the feedback capacitor Cf is connected to the other end of the feedback resistor Rf, the other end of the first resistor R1 is connected to the reverse input terminal of the third amplifier, the non-inverting input terminal of the third amplifier is grounded, and the output terminal of the third amplifier is connected to one end of the second resistor R2. The other end of is connected to the first input end of the linear isolator 401, the second input end of the linear isolator 401 is connected to the first power supply, the third input end of the linear isolator 401 is connected to the inverting input end of the third amplifier, the fourth input end of the linear isolator 401 is grounded, the first output end of the linear isolator 401 is grounded, the second output end of the linear isolator 401 is connected to the inverting input end of the fourth amplifier, the same-direction input end of the fourth amplifier is grounded, the output end of the fourth amplifier outputs an analog voltage signal, one end of the third resistor R3 is connected to the output end of the fourth amplifier, and the other end of the third resistor R3 is connected to the inverting input end of the fourth amplifier.

[0057] Among them, the glucose sensor generates a current and detects a voltage through a transimpedance amplifier TIA:

[0058] Vout=VDAC1+IsRf;

[0059] Among them, the third operational amplifier U3 and the fourth operational amplifier U4, the linear isolator 401, the first resistor R1, the second resistor R2, and the third resistor R3 form a linear isolation voltage circuit. The linear isolator 401 adopts a high-linearity analog linear isolator 401. The micro-current conversion voltage Vout is connected in series with the first resistor R1 and connected to the inverting end of the third operational amplifier U3. The inverting end of the third operational amplifier U3 is connected to the cathode of the photodiode before isolation of the linear isolator 401. The in-phase end of the third operational amplifier U3 is grounded. The output end of the third operational amplifier U3 is connected in series with the second resistor R2 and connected to the cathode of the linear isolator 401 light-emitting diode. The anode of the linear isolator 401 light-emitting diode is connected to the power supply. The anode of the photodiode before isolation of the linear isolator 401 is grounded. The cathode of the photodiode after isolation of the linear isolator 401 is connected to the inverting end of the fourth operational amplifier U4. The anode of the photodiode after isolation of the linear isolator 401U5 is grounded. The inverting end of the fourth operational amplifier U4 is connected to the resistor R3 in parallel to the output end of the fourth operational amplifier U4. The light-emitting diode is turned on to work, and the light it emits will be received by the photodiodes before and after isolation at the same time. For ease of calculation, R1 can be set to R3. At this time, the output voltage after the isolation circuit is:

[0060] Vout1= K3*Vout*R3 / R1=K3*(VDAC1+IsRf);

[0061] Among them, K3 is the optocoupler transmission gain, and its typical value is 1.

[0062] like Figure 4 As shown in Figure 4 2 shows that a single-channel isolated current detection unit realizes linear output after isolation, and the multi-channel isolated current detection unit 205 is implemented by being composed of a plurality of identical single-channel isolated current detection units.

[0063] The data monitoring system for the glucose sensor proposed in the present application can at least control the multi-channel current signal generating module and the multi-channel current data processing module through the control module to detect large quantities of glucose sensors, and the detection channels of each glucose sensor do not interfere with each other. The operation is simple and the degree of automation is high. The traditional calibration method is avoided, and the problem of frequent blood sugar measurement (finger prick) for calibration is avoided, which brings a poor user experience to patients.

[0064] In addition, a current change curve can be formed through the host computer, and the current response curve and sensitivity attenuation curve of the glucose sensor under different glucose concentration changes can be used to characterize the sensitivity of batch production of glucose sensors, which is beneficial to ensure batch production of sensors with low variability and realize factory calibration-free operation of glucose sensors.

[0065] In the description of this specification, the description with reference to the terms "one of the embodiments", "some embodiments", "other embodiments", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example.

[0066] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0067] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A data monitoring system for a glucose sensor, characterized in that: The system comprises: A multi-channel current signal generating module is electrically connected to the control module, and is used to apply solutions with different glucose concentrations to the multiple glucose sensors to form multiple test samples according to the multiple sample addition control signals output by the control module, and is used to load the multiple glucose sensors to test the multiple test samples according to the excitation signal output by the control module, so as to obtain a current signal corresponding to each test sample; A multi-channel current data processing module, electrically connected to the control module and the multi-channel current signal generating module, respectively, for converting a plurality of current signals into a plurality of analog voltage signals, and converting a plurality of analog voltage signals into a plurality of digital voltage signals; The control module is electrically connected to the multi-channel current signal generating module and the multi-channel current data processing module respectively, and is used to form a plurality of excitation signals and to convert the plurality of current signals into a plurality of digital signals.

2. The system according to claim 1, characterized in that The multi-channel current signal generating module comprises a signal excitation submodule and a charging submodule, wherein the signal excitation submodule and the charging submodule are electrically connected to the control module respectively, and the signal excitation submodule and the charging submodule are connected through a pipeline; Wherein, the sample adding module is used to apply solutions with different glucose concentrations to form multiple test samples according to multiple sample adding control signals output by the control module; The signal excitation submodule is used to control multiple glucose sensors to detect multiple detection samples according to the detection signal of the control module, so as to obtain a current signal corresponding to each detection sample.

3. The system according to claim 2, characterized in that The sample loading module includes an automatic sample loading unit and a constant temperature water bath, wherein the automatic sample loading unit is electrically connected to the control module and is connected to the constant temperature water bath through a pipeline; The automatic sample adding unit is used to input glucose of a concentration corresponding to each sample adding control signal output by the control module through a pipeline into the constant temperature water bath; The constant temperature water bath is used to load glucose solutions of different concentrations and control the temperature to a target temperature, thereby forming a plurality of detection samples of the target temperature, and transmitting the plurality of target detection samples to the signal excitation submodule.

4. The system according to claim 2, characterized in that The signal excitation submodule includes a plurality of glucose sensors and a multi-channel excitation unit, wherein the multi-channel excitation unit is electrically connected to the control module and the plurality of glucose sensors respectively, and each glucose sensor is electrically connected to the multi-channel current data processing module and connected to the charging submodule; Wherein, the multi-channel excitation unit is used to load multiple glucose sensors according to the excitation signal output by the control module; Each glucose sensor is used to receive the bias voltage signal loaded by the multi-channel excitation unit, form multiple samples of glucose solutions with different concentrations for detection, and transmit the detected current signal to the multi-channel current data processing module.

5. The system according to claim 1, characterized in that The multi-channel current data processing module includes a multi-channel isolation current detection unit and a multi-channel synchronous analog-to-digital conversion unit, wherein the multi-channel isolation current detection unit is electrically connected to the multi-channel synchronous analog-to-digital conversion module and a plurality of glucose sensors respectively, and the multi-channel synchronous analog-to-digital conversion module is also electrically connected to the control module; Wherein, the multi-channel isolation current detection unit is used to obtain current signals of multiple glucose sensors and convert the multiple current signals into multiple analog voltage signals; The multi-channel synchronous analog-to-digital conversion unit is used to convert multiple analog voltage signals into multiple digital voltage signals, and transmit the multiple digital voltage signals to the control module.

6. The system according to claim 5, characterized in that The multi-channel current data processing module further includes: The multi-channel filtering circuit is electrically connected between the multi-channel isolation current detection unit and the multi-channel synchronous analog-to-digital conversion unit, and is used for filtering each analog voltage signal output by the multi-channel isolation current detection unit.

7. The system according to claim 1, characterized in that The system further comprises: The host computer is electrically connected to the control module and is used to obtain a plurality of digital signals output by the control module and to determine a current variation curve according to the plurality of digital signals.

8. The system according to claim 4, characterized in that The multi-channel excitation unit includes a DAC chip and a plurality of excitation circuits, each excitation circuit includes a first operational amplifier and a second operational amplifier, and the DAC chip includes a plurality of reference voltage output pins; Among them, the non-inverting input terminal of the first operational amplifier is connected to a reference voltage output pin of the DAC chip, the inverting input terminal of the first operational amplifier is electrically connected to a first electrode connection point of a glucose sensor, the inverting input terminal of the second operational amplifier is electrically connected to another reference voltage output pin of the DAC chip, the non-inverting input terminal of the second operational amplifier is electrically connected to a reference electrode connection point of a glucose sensor, and the output terminal of the second operational amplifier is connected to a second electrode connection point of a glucose sensor.

9. The system according to claim 5, characterized in that The multi-channel isolation current detection unit includes a plurality of isolation current detection circuits, each isolation current detection circuit includes a transimpedance amplifier, a third operational amplifier, a fourth operational amplifier, a linear isolator, a first resistor, a second resistor, a third resistor, a feedback resistor and a feedback capacitor; The non-inverting input terminal of the transimpedance amplifier is connected to the current output terminal of a glucose sensor, the output terminal of the transimpedance amplifier is respectively connected to one end of the first resistor and one end of the feedback resistor, the other end of the feedback resistor is connected to the inverting input terminal of the transimpedance amplifier, one end of the feedback capacitor is connected to one end of the feedback resistor, the other end of the feedback capacitor is connected to the other end of the feedback resistor, the other end of the first resistor is connected to the inverting input terminal of the third amplifier, the non-inverting input terminal of the third amplifier is grounded, the output terminal of the third amplifier is connected to one end of the second resistor, the other end of the second resistor is connected to the first input terminal of the linear isolator, the second input terminal of the linear isolator is connected to the first power supply, the third input terminal of the linear isolator is connected to the inverting input terminal of the third amplifier, the fourth input terminal of the linear isolator is grounded, the first output terminal of the linear isolator is grounded, the second output terminal of the linear isolator is connected to the inverting input terminal of the fourth amplifier, the non-inverting input terminal of the fourth amplifier is grounded, the output terminal of the fourth amplifier outputs an analog voltage signal, one end of the third resistor is connected to the output terminal of the fourth amplifier, and the other end of the third resistor is connected to the inverting input terminal of the fourth amplifier.

10. The system according to claim 1, characterized in that The constant temperature water bath also includes a plurality of fixed connection devices, each of which is used to immerse a glucose sensor in the constant temperature water bath device, and the two-sided clamps of each fixed connection device include a plurality of ejector pins, each of which is connected to a plurality of electrode contacts of the glucose sensor in turn, and the plurality of electrode contacts are led out through a plurality of wires.

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