Double-drug-loading negative poisson ratio fabric dressing and preparation method thereof

Abstract

The invention relates to a double-drug-loading negative poisson ratio fabric dressing and a preparation method thereof, and belongs to the technical field of crossing of biomedicine and textile materials. The double-drug-loading negative poisson ratio fabric dressing comprises double-drug-loading hydrogel fibers, the double-drug-loading hydrogel fibers comprise a first drug-loading layer and a second drug-loading layer, the first drug-loading layer carries an antibacterial and anti-inflammatory drug, the first drug-loading layer is formed on the outer surface of the second drug-loading layer, the second drug-loading layer carries an anti-scar drug, the first drug-loading layer is formed on the outer surface of the second drug-loading layer, and the second drug-loading layer is formed on the outer surface of the second drug-loading layer. The double-drug-loading hydrogel fiber is woven into the negative Poisson's ratio fabric dressing. The antibacterial and anti-inflammatory medicine can effectively inhibit wound infection, the anti-scar medicine can avoid scar generation in the tissue regeneration process, the negative Poisson's ratio fabric can be tightly attached to wounds of complex parts such as human joints due to the characteristic, adaptive adjustment can be conducted according to different wound shapes and sizes, and the negative Poisson's ratio fabric can be applied to the field of medical treatment. And the shape self-adaptability of the fabric dressing is realized.

Description

Technical Field

[0001] The invention belongs to the cross-technical field of biomedicine and textile materials, and specifically relates to a double-drug-loaded negative Poisson's ratio fabric dressing and a preparation method thereof. Background Art

[0002] As a medical product that comes into direct contact with the wound, the performance of wound dressings directly affects the wound healing effect and the patient's comfort. With the continuous advancement of medical technology, the requirements for wound dressings are becoming higher and higher. They are not only required to have the basic functions of hemostasis and wound protection, but also to be able to intelligently respond to the wound environment, promote wound healing and reduce scar formation.

[0003] Traditional wound treatment materials, such as gauze and bandages, can protect wounds and reduce infection to a certain extent, but they have obvious deficiencies in promoting wound healing, reducing scar formation, and adapting to complex skin surfaces. In recent years, with the rapid development of textile material science and biomedical technology, new wound treatment materials have continued to emerge. Among them, hydrogel, as a material with excellent biocompatibility, high water absorption and water retention capacity, has received extensive attention in the fields of trauma treatment, drug sustained release, and tissue engineering. The softness and moist environment of hydrogel help maintain the moist environment of the wound, promote cell proliferation and migration, and thus accelerate wound healing. However, there are still some challenges in the preparation and application of existing hydrogel materials. On the one hand, how to accurately load drugs in hydrogels and achieve controlled release is the key to improving the therapeutic effect; on the other hand, how to make hydrogel materials adapt to complex skin surfaces such as human joints and improve wearing comfort and therapeutic effects is also a technical problem that needs to be solved urgently. Summary of the invention

[0004] The present invention proposes a dual-drug loaded negative Poisson's ratio fabric dressing and a preparation method thereof, aiming to partially or completely solve the technical problems in the prior art such as how to achieve drug release and how the hydrogel material can adapt to complex skin surfaces such as joints. By weaving the dual-drug loaded hydrogel fibers into a fabric dressing with negative Poisson's ratio characteristics, it is helpful to achieve accurate loading and controllable release of drugs, and can well adapt to complex skin surfaces such as human joints. The technical solution of the present invention is as follows:

[0005] In a first aspect, a dual-drug loaded fabric dressing with negative Poisson's ratio comprises: dual-drug loaded hydrogel fibers, the dual-drug loaded hydrogel fibers comprising a first drug loaded layer and a second drug loaded layer, the first drug loaded layer carries antibacterial and anti-inflammatory drugs, the first drug loaded layer is formed on the outer surface of the second drug loaded layer, the second drug loaded layer carries anti-scar drugs, and the dual-drug loaded hydrogel fibers are woven into a negative Poisson's ratio fabric dressing.

[0006] Optionally, along the first direction, the coil density of the negative Poisson's ratio fabric dressing is 25-35 coils / inch, and along the second direction, the coil density of the negative Poisson's ratio fabric dressing is 20-30 coils / inch, and the first direction and the second direction intersect.

[0007] Optionally, the negative Poisson's ratio fabric dressing comprises a zigzag-shaped spatial structure, and the coil length of the negative Poisson's ratio fabric dressing is greater than the coil width.

[0008] Optionally, the coil length is 5-10 mm, and / or the coil width is 3-8 mm; the first drug-carrying layer includes sodium alginate and polyvinyl alcohol, and the second drug-carrying layer includes sodium alginate.

[0009] In a second aspect, a method for preparing a double-drug-loaded negative Poisson's ratio fabric dressing is provided, wherein the polyester fiber having a phase change temperature regulating function as described in any one of the first aspects is prepared, comprising the following steps:

[0010] Step S100: preparing dual-drug-loaded hydrogel fibers by wet spinning;

[0011] Step S100 includes:

[0012] Step S101: preparing a spinning solution containing antibacterial and anti-inflammatory drugs;

[0013] Step S102: preparing a spinning solution containing an anti-scar drug;

[0014] Step S103: using the spinning solution containing antibacterial and anti-inflammatory drugs as the first drug-carrying layer spinning solution, and the spinning solution containing anti-scar drugs as the second drug-carrying layer spinning solution, and performing wet spinning operation through a coaxial spinning nozzle, wherein the solute of the coagulation bath in the wet spinning operation is calcium chloride, the solvent is deionized water, and the concentration of calcium chloride is 2%-10%; the spinning speed of the first drug-carrying layer spinning solution is controlled at 10-30m / min, the spinning speed of the second drug-carrying layer spinning solution is controlled at 1-15m / min, and the spinning temperature is controlled at 20-40°C, so as to prepare a double drug-carrying hydrogel fiber;

[0015] Step S101 and step S102 may be performed sequentially, first after, or simultaneously;

[0016] Step S200: weaving the dual-drug loaded hydrogel fibers into a negative Poisson's ratio fabric dressing.

[0017] Optionally, step S101 includes:

[0018] Sodium alginate and polyvinyl alcohol are used as solutes and deionized water is used as solvent. Sodium alginate, polyvinyl alcohol and deionized water are mixed to prepare a mixed solution with a total solute concentration of 2.5%-5%. Antibacterial and anti-inflammatory drugs are added into the mixed solution to prepare a spinning solution containing the antibacterial and anti-inflammatory drugs.

[0019] Optionally, step S102 includes:

[0020] Sodium alginate is used as a solute and deionized water is used as a solvent. Sodium alginate and deionized water are mixed to prepare a mixed solution with a total solute concentration of 1.5%-3%. Anti-scar drugs are added into the mixed solution to prepare a spinning solution containing the anti-scar drugs.

[0021] Optionally, step S200 includes:

[0022] The double-drug-loaded hydrogel fibers are woven on a flat knitting machine, and the positive and negative coils are arranged alternately to form a fabric dressing with a spatial structure including a zigzag arrangement. Along the first direction, the coil density is 25-35 coils / inch, and along the second direction, the coil density is 20-30 coils / inch. The yarn feeding speed is 10-30m / min, the needle pitch is 10-14 needles / 25.2mm, and the first direction and the second direction intersect.

[0023] Optionally, in step S101, the antibacterial and anti-inflammatory drugs include but are not limited to penicillin antibiotics, cephalosporin antibiotics, tetracycline antibiotics, and quinolone antibiotics; in step S102, the anti-scar drugs include but are not limited to silicones and glucocorticoids.

[0024] The beneficial effects achieved by the present invention are as follows:

[0025] (1) In the present invention, the dual-drug-loaded negative Poisson's ratio fabric dressing includes dual-drug-loaded hydrogel fibers, wherein the antibacterial and anti-inflammatory drugs and the anti-scar drugs are formed on the first drug-loaded layer and the second drug-loaded layer, respectively, and the first drug-loaded layer is formed on the outer surface of the second drug-loaded layer. The dual-drug-loaded hydrogel fibers can carry the antibacterial and anti-inflammatory drugs and the anti-scar drugs at the same time, and can play a targeted role in different stages of wound healing. In the early stage of wound healing, the antibacterial and anti-inflammatory drugs are released from the first drug-loaded layer, and the antibacterial and anti-inflammatory drugs can effectively resist bacterial infection at the wound, reduce inflammatory response, create a clean and stable microenvironment for wound healing, reduce the risk of infection, and effectively promote the acceleration of the wound healing process; when the wound healing enters the late stage, the anti-scar drugs are gradually released from the second drug-loaded layer. The presence of the anti-scar drugs can inhibit the excessive proliferation of scar tissue, contribute to the flatness and beauty of the wound after healing, and greatly alleviate the dual adverse effects of scars on patients at the physiological and psychological levels;

[0026] (2) In the present invention, the negative Poisson's ratio fabric dressing has unique mechanical properties. When stretched, it will expand laterally, and can perfectly fit the irregular wound contours of various parts of the body, especially can adapt well to complex skin surfaces such as human joints, ensure that the fabric dressing and the wound always maintain a close and seamless contact state, and make adaptive adjustments according to different wound shapes and sizes to ensure the perfect fit between the fabric dressing and the wound, thus achieving shape adaptability. Not only that, this close fit can also prevent the invasion of external pollutants, enhance the protection of the wound, facilitate the uniform and continuous release of drugs at the wound site, improve the sustained release effect and utilization rate of drugs at the wound site, and provide a more ideal microenvironment for wound healing, achieve a significant acceleration of the wound repair process, and significantly optimize and improve the comprehensive performance and wound treatment effect of the dressing in wound treatment; BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the description of the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0028] Figure 1 This is a schematic structural diagram of the dual drug-loaded hydrogel fiber applied for in the present invention.

[0029] Figure 2 This is a schematic structural diagram of a double-drug-loaded negative Poisson's ratio fabric dressing applied for by the present invention.

[0030] Figure 3 This is a schematic flow chart of a method for preparing a double-drug-loaded negative Poisson's ratio fabric dressing applied for by the present invention.

[0031] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments; based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0033] In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside" and the like indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention. "Including" can at least be understood as the meaning of only including. In order to make the purpose, technical solutions and advantages of the present invention clearer, the implementation methods of the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0034] In a first aspect, a dual-drug loaded fabric dressing with negative Poisson's ratio includes: dual-drug loaded hydrogel fibers, the dual-drug loaded hydrogel fibers include a first drug loaded layer 100 and a second drug loaded layer 200, the first drug loaded layer carries antibacterial and anti-inflammatory drugs, the first drug loaded layer is formed on the outer surface of the second drug loaded layer, the second drug loaded layer carries anti-scar drugs, and the dual-drug loaded hydrogel fibers are woven into a negative Poisson's ratio fabric dressing.

[0035] In the present application, firstly, the dual-drug-loaded negative Poisson's ratio fabric dressing includes dual-drug-loaded hydrogel fibers, the antibacterial and anti-inflammatory drugs and the anti-scar drugs are formed on the first drug-loaded layer and the second drug-loaded layer, respectively, the first drug-loaded layer is formed on the outer surface of the second drug-loaded layer, and the dual-drug-loaded hydrogel fibers can carry the antibacterial and anti-inflammatory drugs and the anti-scar drugs at the same time, and can play a targeted role in sequence at different stages of wound healing. In the early stage of wound healing, the antibacterial and anti-inflammatory drugs are released from the first drug-loaded layer, and the antibacterial and anti-inflammatory drugs can effectively resist bacterial infection at the wound, reduce inflammatory response, create a clean and stable microenvironment for wound healing, reduce the risk of infection, and effectively promote the acceleration of the wound healing process; when the wound healing enters the late stage, the anti-scar drugs are released from the first drug-loaded layer. The scar drug is gradually released from the second drug-carrying layer. The presence of anti-scar drugs can inhibit the excessive proliferation of scar tissue, help the wound to be smooth and beautiful after healing, and greatly alleviate the dual adverse effects of scars on patients' physiological and psychological aspects. In addition, the negative Poisson's ratio fabric dressing has unique mechanical properties. When stretched, it will expand laterally, and can perfectly fit the irregular wound contours of various parts of the body, especially the complex skin surfaces such as human joints, ensuring that the fabric dressing and the wound always maintain a close and seamless contact state, and make adaptive adjustments according to different wound shapes and sizes to ensure the perfect fit between the fabric dressing and the wound, thus realizing the shape adaptability of the fabric dressing. Not only that, this close fit can also prevent the invasion of external pollutants, enhance the protection of the wound, and facilitate the uniform and continuous release of drugs at the wound site, improve the sustained release effect and utilization rate of drugs at the wound site, and provide a more ideal microenvironment for wound healing, greatly accelerate the wound repair process, and significantly optimize and improve the comprehensive performance and wound treatment effect of the dressing in wound treatment.

[0036] Optionally, along the first direction, the coil density of the negative Poisson's ratio fabric dressing is 25-35 coils / inch, and along the second direction, the coil density of the negative Poisson's ratio fabric dressing is 20-30 coils / inch, and the first direction and the second direction intersect.

[0037] In the present application, firstly, there are 25-35 coils / inch in the first direction and 20-30 coils / inch in the second direction. The coil density distribution in the first direction and the second direction enables the fabric dressing to have appropriate elasticity in different directions, maintains the structural stability of the fabric dressing during use, and different coil density arrangements and combinations can allow the fabric dressing to better fit the curves of different parts of the human body. Whether the fabric dressing is bent or stretched, the fabric dressing can fit the wound tightly and provide a good fitting effect. In addition, the coil density distribution in the first direction and the second direction helps to adjust the air permeability of the fabric dressing, so that the wound is in a suitable microenvironment, which is conducive to wound healing. It should be noted that the first direction and the second direction intersect, and the first direction can be the lateral direction of the fabric dressing with a negative Poisson's ratio (i.e. Figure 2 The second direction may be the longitudinal direction of the negative Poisson's ratio fabric dressing (i.e. Figure 2 The first direction and the second direction may be perpendicular to each other.

[0038] Optionally, the negative Poisson's ratio fabric dressing comprises a zigzag-shaped spatial structure, and the coil length of the negative Poisson's ratio fabric dressing is greater than the coil width.

[0039] In the present application, the zigzag-shaped spatial structure gives the dressing good elasticity and flexibility. When stretched by external force, the zigzag structure can effectively disperse the stress and avoid stress concentration, thereby reducing the risk of rupture of the fabric dressing. Moreover, the design that the coil length is greater than the coil width increases the deformability of the fabric in the stretching direction, allowing the fabric dressing to better adapt to wounds of different shapes and sizes, fit closely to the wound surface, effectively prevent the invasion of external bacteria, and enhance the air permeability of the fabric dressing, creating a good healing environment for the wound and helping the wound to recover faster.

[0040] Optionally, the coil length is 5-10 mm, and / or the coil width is 3-8 mm.

[0041] In the present application, the setting of the coil length helps the dressing to have enough margin to adapt to different degrees of deformation when stretched. For example, when bandaging active parts such as joints, it can change flexibly with the bending and stretching of the limbs without being too tight or loose. The range of coil width can ensure that the fabric has good support and can maintain a stable structure when covering the wound. At the same time, it can also keep the dressing appropriately breathable, which is beneficial to the air exchange of the wound and promotes the healing of the wound.

[0042] Optionally, the first drug-carrying layer includes sodium alginate and polyvinyl alcohol, and the second drug-carrying layer includes sodium alginate.

[0043] In the present application, firstly, the application of sodium alginate in the first drug-carrying layer and the second drug-carrying layer is helpful for the loading and sustained release of drugs. Sodium alginate has good biocompatibility and can avoid irritation to wounds. Sodium alginate can form a gel-like structure, which can effectively adsorb drugs and control the release rate of drugs, so that the drugs can act on wounds continuously and stably. In addition, the polyvinyl alcohol in the first drug-carrying layer cooperates with sodium alginate to improve the mechanical properties of the first drug-carrying layer. Polyvinyl alcohol can make the first drug-carrying layer stronger and not easy to be damaged during the use of the fabric dressing, thereby better exerting the drug loading and treatment effects.

[0044] In a second aspect, a method for preparing a double drug-loaded negative Poisson's ratio fabric dressing is provided, wherein the method comprises the following steps:

[0045] Step S100: preparing dual-drug-loaded hydrogel fibers by wet spinning;

[0046] Specifically, step S100 includes:

[0047] Step S101: preparing a spinning solution containing antibacterial and anti-inflammatory drugs;

[0048] Specifically, step S101 includes:

[0049] Using sodium alginate and polyvinyl alcohol as solutes and deionized water as solvent, sodium alginate, polyvinyl alcohol and deionized water are mixed to prepare a mixed solution with a total solute concentration of 2.5%-5%, and antibacterial and anti-inflammatory drugs are added to the mixed solution to prepare a spinning solution containing antibacterial and anti-inflammatory drugs. For example, the total solute concentration is 3.5%, and ofloxacin is selected as the antibacterial and anti-inflammatory drug, and the drug concentration is 0.3%.

[0050] In step S101, sodium alginate and polyvinyl alcohol are used as solutes and deionized water is used as solvent to prepare a mixed solution of a specific concentration, which can ensure that the spinning solution has suitable viscosity and filament forming properties, which is conducive to the stable subsequent spinning process. The combination of sodium alginate and polyvinyl alcohol not only gives the spinning solution good biocompatibility, but also enhances its mechanical strength, making the formed fiber tough and not easy to break. Adding ofloxacin as an antibacterial and anti-inflammatory drug, and controlling it at a concentration of 0.3%, can effectively kill bacteria and reduce inflammation while avoiding adverse reactions caused by excessive drugs, accurately acting on wounds, and promoting wound healing and recovery.

[0051] Step S102: preparing a spinning solution containing an anti-scar drug;

[0052] Specifically, step S102 includes:

[0053] Sodium alginate is used as a solute and deionized water is used as a solvent. Sodium alginate and deionized water are mixed to prepare a mixed solution with a total solute concentration of 1.5%-3%. Anti-scar drugs are added to the mixed solution to prepare a spinning solution containing anti-scar drugs. For example, the total solute concentration is 2%, and triamcinolone acetonide is selected as the anti-scar drug, and the drug concentration is 20 g / L.

[0054] In step S102, firstly, sodium alginate is used as a solute and deionized water is used as a solvent to prepare a mixed solution of a specific concentration, which provides a good basis for spinning. The good biocompatibility of sodium alginate can reduce stimulation to the human body, and the appropriate concentration ensures the stability of the spinning solution performance; secondly, triamcinolone acetonide is added as an anti-scar drug. When its concentration is 20 g / L, it can effectively inhibit scar formation-related processes such as fibroblast proliferation, act accurately in the wound healing stage, and reduce the probability of scar formation; at the same time, the preparation method of the spinning solution is conducive to the uniform distribution of the drug in the fiber, so that the drug is continuously and stably released, thereby improving the anti-scar treatment effect.

[0055] It should be noted that step S101 and step S102 can be performed sequentially, first after, or simultaneously.

[0056] Step S103: Using the spinning solution containing antibacterial and anti-inflammatory drugs as the spinning solution of the first drug-carrying layer, and the spinning solution containing anti-scar drugs as the spinning solution of the second drug-carrying layer, wet spinning operation is performed through a coaxial spinning nozzle, wherein the solute of the coagulation bath in the wet spinning operation is calcium chloride, the solvent is deionized water, and the concentration of calcium chloride is 2%-10%; the spinning speed of the first drug-carrying layer spinning solution is controlled at 10-30m / min, the spinning speed of the second drug-carrying layer spinning solution is controlled at 1-15m / min, and the spinning temperature is controlled at 20-40°C to prepare double drug-carrying hydrogel fibers.

[0057] In step S103, firstly, a dual drug-carrying layer structure is realized through a coaxial spinning nozzle, so that the antibacterial and anti-inflammatory drugs and anti-scar drugs can be accurately positioned in the first drug-carrying layer and the second drug-carrying layer, respectively, so that the two drugs can play a role in different stages of wound healing; in the coagulation bath stage, calcium chloride as a solute can effectively coagulate the spinning solution, and its concentration range ensures good fiber forming; the control of the spinning speed and temperature makes the fiber forming process more stable and uniform, and can effectively avoid defects such as uneven thickness of the fiber; the dual drug-carrying hydrogel fiber finally prepared can provide continuous antibacterial and anti-inflammatory for the wound, while taking into account the anti-scar function, which is conducive to better recovery of the wound.

[0058] Step S200: weaving the dual-drug loaded hydrogel fibers into a negative Poisson's ratio fabric dressing.

[0059] Specifically, step S200 includes:

[0060] The double-drug-loaded hydrogel fibers are woven on a flat knitting machine, and the positive and negative coils are arranged alternately to form a fabric dressing with a zigzag spatial structure. Along the first direction, the coil density is 25-35 coils / inch, and along the second direction, the coil density is 20-30 coils / inch. The first direction and the second direction intersect.

[0061] Exemplarily, the flat knitting machine gauge is CMS 530HP computer flat knitting machine, the double-drug-loaded hydrogel fiber is woven by the CMS 530HP computer flat knitting machine, the positive and negative coils are arranged alternately to form a fabric dressing, the yarn feeding speed is 10-30 m / min, the needle pitch is 10-14 needles / 25.2 mm, along the first direction, the coil density is 25-35 coils / inch in the transverse direction, and along the second direction, the coil density is 20-30 coils / inch, the knitting structure is designed to have a coil length of 8 mm, a coil width of 6 mm, a yarn diameter of 0.2 mm, a coil density of 25 coils / inch in the first direction and a coil density of 25 coils / inch in the second direction.

[0062] In the present invention application, a fabric dressing is made by weaving double-drug-loaded hydrogel fibers using a flat knitting machine. The zigzag spatial structure is matched with a specific coil density, so that the fabric dressing has good elasticity and fit in different directions, can tightly wrap the wound, and adapt to complex skin surfaces such as human joints; the structural parameters of the fabric dressing include: coil length, width, yarn diameter, etc., which ensure the stability of the fabric dressing structure, which is neither too loose to affect the efficacy of the medicine, nor too tight to hinder breathability, so that antibacterial, anti-inflammatory and anti-scar drugs can act accurately on the wound, create a favorable healing environment for the wound, promote tissue repair, and reduce complications.

[0063] Optionally, in step S101, the antibacterial and anti-inflammatory drugs include but are not limited to penicillin antibiotics, cephalosporin antibiotics, tetracycline antibiotics, and quinolone antibiotics; in step S102, the anti-scar drugs include but are not limited to silicones and glucocorticoids.

[0064] In the present invention application, different types of antibacterial and anti-inflammatory drugs, such as penicillins and cephalosporins, can act against a variety of pathogens, effectively kill various bacteria that cause wound infection, reduce inflammatory reactions, and prevent the spread of infection; at the same time, silicones and glucocorticoids in anti-scar drugs can inhibit scar formation from different mechanisms, silicones can improve the appearance of scars, and glucocorticoids can regulate cell activity and reduce excessive collagen fiber proliferation. Therefore, a variety of drug combinations can be flexibly allocated according to the patient's specific condition, constitution, and allergy history, etc., to improve the pertinence and effectiveness of treatment.

[0065] Therefore, in the present application, dual-drug loaded hydrogel fibers are prepared by wet spinning technology, which realizes the precise loading and release of antibacterial, anti-inflammatory and anti-scar drugs, improves the sustained-release effect and utilization rate of drugs at the wound, and can also provide a more ideal microenvironment for wound healing, thereby greatly accelerating the wound repair process; the design of the negative Poisson's ratio knitted structure enables the lateral dimension of the fabric dressing to increase moderately when stretched, so that it can better fit the skin, especially complex body surface forms such as human joints, which not only improves the fit and comfort of the fabric dressing, but also helps to reduce friction and pressure at the wound, promotes wound healing, and can also be adaptively adjusted according to different wound shapes and sizes to ensure perfect fit between the fabric dressing and the wound, thereby realizing the shape adaptability of the fabric dressing.

[0066] The drawings are only one of the embodiments of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design a structure and embodiment similar to the technical solution without creativity without departing from the purpose of the present invention, they should all fall within the protection scope of the present invention.

Claims

1. A double drug-loaded negative Poisson's ratio fabric dressing, characterized in that: include: Double drug-loaded hydrogel fiber, the double drug-loaded hydrogel fiber includes a first drug-loaded layer and a second drug-loaded layer, the first drug-loaded layer carries antibacterial and anti-inflammatory drugs, the first drug-loaded layer is formed on the outer surface of the second drug-loaded layer, the second drug-loaded layer carries anti-scar drugs, and the double drug-loaded hydrogel fiber is woven into a negative Poisson's ratio fabric dressing.

2. A double drug-loaded negative Poisson's ratio fabric dressing according to claim 1, characterized in that: Along the first direction, the coil density of the negative Poisson's ratio fabric dressing is 25-35 coils / inch, and along the second direction, the coil density of the negative Poisson's ratio fabric dressing is 20-30 coils / inch. The first direction and the second direction intersect.

3. A double drug-loaded negative Poisson's ratio fabric dressing according to claim 2, characterized in that: The negative Poisson's ratio fabric dressing comprises a zigzag-shaped spatial structure, and the coil length of the negative Poisson's ratio fabric dressing is greater than the coil width.

4. A double drug-loaded negative Poisson's ratio fabric dressing according to claim 3, characterized in that: The coil length is 5-10 mm, and / or the coil width is 3-8 mm; the first drug-carrying layer includes sodium alginate and polyvinyl alcohol, and the second drug-carrying layer includes sodium alginate.

5. A method for preparing a double drug-loaded negative Poisson's ratio fabric dressing, comprising preparing a double drug-loaded negative Poisson's ratio fabric dressing according to any one of claims 1 to 4, characterized in that: The following steps are involved: Step S100: preparing dual-drug-loaded hydrogel fibers by wet spinning; Step S100 includes: Step S101: preparing a spinning solution containing antibacterial and anti-inflammatory drugs; Step S102: preparing a spinning solution containing an anti-scar drug; Step S103: using the spinning solution containing antibacterial and anti-inflammatory drugs as the spinning solution for the first drug-carrying layer, and the spinning solution containing anti-scar drugs as the spinning solution for the second drug-carrying layer, and performing a wet spinning operation through a coaxial spinning nozzle, wherein the solute of the coagulation bath in the wet spinning operation is calcium chloride, the solvent is deionized water, and the concentration of calcium chloride is 2%-10%; The spinning speed of the first drug-carrying layer spinning solution is controlled at 10-30 m / min, the spinning speed of the second drug-carrying layer spinning solution is controlled at 1-15 m / min, and the spinning temperature is controlled at 20-40° C. to prepare a double drug-carrying hydrogel fiber; Step S101 and step S102 can be performed sequentially, first after, or simultaneously; Step S200: weaving the dual-drug loaded hydrogel fibers into a negative Poisson's ratio fabric dressing.

6. The method for preparing a double drug-loaded negative Poisson's ratio fabric dressing according to claim 3, characterized in that: Step S101 includes: Sodium alginate and polyvinyl alcohol are used as solutes and deionized water is used as solvent. Sodium alginate, polyvinyl alcohol and deionized water are mixed to prepare a mixed solution with a total solute concentration of 2.5%-5%. Antibacterial and anti-inflammatory drugs are added into the mixed solution to prepare a spinning solution containing the antibacterial and anti-inflammatory drugs.

7. The method for preparing a double drug-loaded negative Poisson's ratio fabric dressing according to claim 4, characterized in that: Step S102 includes: Sodium alginate is used as a solute and deionized water is used as a solvent. Sodium alginate and deionized water are mixed to prepare a mixed solution with a total solute concentration of 1.5%-3%. Anti-scar drugs are added into the mixed solution to prepare a spinning solution containing the anti-scar drugs.

8. The method for preparing a double drug-loaded negative Poisson's ratio fabric dressing according to claim 5, characterized in that: Step S200 includes: The double-drug-loaded hydrogel fibers are woven on a flat knitting machine, and the positive and negative coils are arranged alternately to form a fabric dressing with a spatial structure including a zigzag arrangement. Along the first direction, the coil density is 25-35 coils / inch, and along the second direction, the coil density is 20-30 coils / inch; the yarn feeding speed is 10-30m / min, the needle pitch is 10-14 needles / 25.2mm, and the first direction and the second direction intersect.

9. The method for preparing a double drug-loaded negative Poisson's ratio fabric dressing according to claim 6, characterized in that: In step S101, the antibacterial and anti-inflammatory drugs include but are not limited to penicillin antibiotics, cephalosporin antibiotics, tetracycline antibiotics, and quinolone antibiotics; in step S102, the anti-scar drugs include but are not limited to silicones and glucocorticoids.

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