A vitamin antidandruff shampoo composition, method of making and use

Abstract

The present application relates to the daily chemical technology field, especially to a vitamin anti-dandruff shampoo composition, a preparation method and application.The composition comprises: hydroxypropyl cyclodextrin, panthenol, tocopheryl acetate, capryloyl glycine, sodium ascorbyl phosphate, nicotinamide, pyridoxine hydrochloride.Vitamin B6 helps to regulate the oil secretion of the scalp, avoids the dandruff problem caused by excessive or insufficient oil.The anti-dandruff shampoo can provide comprehensive hair care effect, improve the scalp environment, thereby effectively reducing the generation of dandruff by reasonably collocating these vitamins.

Description

A vitamin-based anti-dandruff shampoo composition, its preparation method, and its application. Technical Field

[0001] This invention relates to the field of daily chemical technology, and in particular to a vitamin-based anti-dandruff shampoo composition, its preparation method, and its application. Background Technology

[0002] Anti-dandruff shampoos are specifically designed to relieve dandruff and scalp itching. They typically contain active ingredients to inhibit fungi, remove dead skin cells, or soothe the scalp. Common ingredients include: Ketoconazole: an antifungal ingredient that effectively combats fungi that cause dandruff; Selenides: have antibacterial and anti-dandruff effects and are commonly used in anti-dandruff products; Salicylic acid: helps remove dead skin cells from the scalp and improves scalp health; Tea tree oil: a natural ingredient with antibacterial and anti-inflammatory properties. While effective, side effects such as scalp dryness and irritation may occur during use.

[0003] Vitamins play many important roles in the body, including: Promoting metabolism: B vitamins participate in energy metabolism, helping to convert food into energy. Antioxidant protection: Vitamins C and E have antioxidant properties, helping to fight free radical damage and protect cell health. Boosting immunity: Vitamins A, C, and D enhance the function of the immune system and improve the body's resistance. Maintaining skin health: Vitamins E and B vitamins help keep skin smooth and promote healing. Bone health: Vitamin D promotes calcium absorption and helps with bone development and maintenance. Promoting blood health: Vitamin K is essential for blood clotting, while vitamin B12 helps in the production of red blood cells. Nervous system function: Certain vitamins (such as B vitamins) are essential for nerve conduction and brain function.

[0004] The purpose of this invention is to provide an anti-dandruff shampoo that has a better anti-dandruff effect while nourishing the scalp and avoiding irritation. Summary of the Invention

[0005] To solve the above-mentioned technical problems, the present invention provides a vitamin anti-dandruff shampoo composition, the composition comprising:

[0006] Hydroxypropyl cyclodextrin

[0007] Panthenol

[0008] Tocopheryl acetate

[0009] Capryloylglycine

[0010] Sodium ascorbate phosphate

[0011] Niacinamide

[0012] Pyridoxine hydrochloride.

[0013] As one embodiment of the present invention, the composition further comprises betaine and tripeptide-1 copper.

[0014] In one embodiment of the present invention, the composition comprises, by weight parts:

[0015] 20 parts hydroxypropyl cyclodextrin, 10 parts panthenol, 5 parts tocopherol acetate, 10 parts capryloyl glycine, 5 parts sodium ascorbate phosphate, 10 parts nicotinamide, and 5 parts pyridoxine hydrochloride.

[0016] In one embodiment of the present invention, the mass ratio of betaine to panthenol is 3:1 to 4:1.

[0017] In one embodiment of the present invention, the mass ratio of tripeptide-1 copper to panthenol is 0.05:1 to 0.2:1.

[0018] As one embodiment of the present invention, the preparation method of the vitamin anti-dandruff shampoo composition includes the following steps:

[0019] S01. Dissolve tocopherol acetate in anhydrous ethanol and disperse evenly.

[0020] S02 Take hydroxypropyl cyclodextrin and dissolve it in deionized water;

[0021] Under the S03 colloid mill conditions, the liquid obtained in step one is slowly added to the liquid obtained in step two, and the equipment is run for 20 minutes after the addition is complete.

[0022] S04 concentrates the mixture obtained in step 3 to recover ethanol, and after spray drying the concentrated paste, adds the remaining components to obtain the final product.

[0023] A vitamin-based anti-dandruff shampoo comprising the aforementioned vitamin-based anti-dandruff shampoo composition.

[0024] As one embodiment of the present invention, the anti-dandruff shampoo further comprises an acidic surfactant.

[0025] In one embodiment of the present invention, the acidic surfactant comprises sodium aspartate and sodium glutamate.

[0026] The aforementioned vitamin-based anti-dandruff shampoo composition is used in the daily chemical industry.

[0027] By adopting the above technical solution, the present invention has the following beneficial effects:

[0028] Vitamins play an important role in the anti-dandruff shampoo of this invention:

[0029] Nourishing the scalp: Vitamin B helps improve scalp health, promotes cell regeneration, enhances scalp resistance, and reduces dandruff production.

[0030] Strengthen hair: Vitamin E is a powerful antioxidant that helps protect hair from environmental damage, maintains its shine and strength, and reduces breakage and damage.

[0031] Moisturizing effect: Vitamin A can regulate the secretion of sebaceous glands, help keep the scalp moisturized, and prevent dandruff problems caused by dryness.

[0032] Vitamin B6 helps regulate scalp sebum secretion, preventing dandruff problems caused by excessive or insufficient sebum. By properly combining these vitamins, anti-dandruff shampoos can provide comprehensive hair care effects, improve the scalp environment, and thus effectively reduce dandruff production. Detailed Implementation

[0033] The technical solution of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0034] This invention provides a vitamin anti-dandruff shampoo composition comprising: 20 parts hydroxypropyl cyclodextrin, 10 parts panthenol, 34.9 parts betaine, 0.1 parts tripeptide-1 copper, 5 parts tocopheryl acetate, 10 parts capryloyl glycine, 5 parts sodium ascorbate phosphate, 10 parts nicotinamide, and 5 parts pyridoxine hydrochloride.

[0035] Another aspect of the present invention provides a method for preparing the aforementioned vitamin anti-dandruff shampoo composition, comprising the following steps:

[0036] S01. Dissolve tocopherol acetate in anhydrous ethanol and disperse evenly.

[0037] S02 Take hydroxypropyl cyclodextrin and dissolve it in deionized water;

[0038] Under the S03 colloid mill conditions, the liquid obtained in step one is slowly added to the liquid obtained in step two, and the equipment is run for 20 minutes after the addition is complete.

[0039] S04 concentrates the mixture obtained in step 3 to recover ethanol, and after spray drying the concentrated paste, adds the remaining components to obtain the final product.

[0040] Another aspect of the present invention provides a vitamin-based anti-dandruff shampoo, the raw materials of which include:

[0041] 0.1 part of disodium EDTA

[0042] 7 parts of a mixture of sodium lauryl ether sulfate and water (mass ratio 3:7)

[0043] 3 parts of sodium aspartate

[0044] 5 parts of monosodium glutamate

[0045] One part of a mixture of palm kernel oleamide DEA, glycerin, and water (mass ratio 3:1:6).

[0046] A mixture of water, sodium cocoyl methyl taurate, cocamidopropyl betaine, sodium chloride, and sodium benzoate (mass ratio 6:1:1:2:2) 1.5 parts

[0047] Sodium citrate 0.05 parts

[0048] 0.5 parts of a mixture of ammonium lauryl sulfate and water (mass ratio 3:7)

[0049] 0.2 parts of a mixture of hydroxypropyl guar gum, hydroxypropyltrimethylammonium chloride, and water (mass ratio 3:7); 0.05 parts of a mixture of guar gum, hydroxypropyltrimethylammonium chloride, and water (mass ratio 3:7).

[0050] Citric acid 0.05 parts

[0051] 0.15 parts allantoin

[0052] Three parts of a mixture of cocamidopropyl betaine, sodium chloride, sodium benzoate, and water (mass ratio 2:1:1:6).

[0053] 1 part of a mixture of glyceryl laurate, cocamidopropyl betaine, and water (mass ratio 2:2:6); 3 parts of a mixture of sodium cocoaminopropionate and water (mass ratio 2:8).

[0054] 0.25 parts of PPG-3 octyl ether

[0055] A mixture of water, polyquaternium-7, phenoxyethanol, and ethylhexylglycerin (mass ratio 5:2:2:1), 1 part; PEG-7 glyceryl cocoate, 0.15 parts.

[0056] 0.3 parts trehalose

[0057] A mixture of water, hydrolyzed silk, phenoxyethanol, acrylamide propyltrimethylammonium chloride / acrylamide copolymer, and ethylhexylglycerin (mass ratio 5:1:1:1:1:1) 0.3 parts

[0058] 0.1 part of a mixture of methylisothiazolinone, benzyl alcohol, propylene glycol, and water (mass ratio 3:1:1:5).

[0059] 1.55 parts sodium chloride

[0060] Vitamin anti-dandruff shampoo composition (8 parts)

[0061] Water to a final volume of 100 portions.

[0062] The preparation method of the vitamin anti-dandruff shampoo described in this invention is as follows:

[0063] 1. Add 50% deionized water to a mixing pot, turn on the stirring, and add disodium EDTA, sodium lauryl ether sulfate, and ammonium lauryl sulfate in sequence. Stir and heat to 70°C, and stir until completely dissolved and transparent.

[0064] 2. Add palm kernel oleamide DEA, sodium citrate, capryloyl glycine, and allantoin, and stir until completely dissolved and transparent.

[0065] 3. Using 10% deionized water in a clean container, mix hydroxypropyl guar gum hydroxypropyl trimethyl ammonium chloride and guar gum hydroxypropyl trimethyl ammonium chloride evenly, add to a mixing pot and stir evenly for 5 minutes, then start cooling.

[0066] 4. When the temperature drops to 60℃~55℃, add sodium cocoyl methyl taurate, cocamidopropyl betaine, sodium chloride, sodium benzoate, glyceryl laurate, sodium cocoyl aminopropionate, PPG-3 octyl ether, polyquaternium-7, phenoxyethanol, ethylhexylglycerin, PEG-7 glyceryl cocoate, and trehalose in sequence, and stir well.

[0067] 5. Once the temperature drops below 45℃, add the remaining ingredients (excluding deionized water) to the mixing bowl and stir until well mixed.

[0068] 6. Stop cooling, add the remaining 40% of deionized water, and stir well.

[0069] Panthenol contains ester bonds and hydroxyl groups, making it susceptible to the effects of water. In the presence of water, the ester bonds can be hydrolyzed. Water molecules nucleophilically attack the ester bonds of panthenol, forming intermediates that subsequently release alcohols or acids. Acidity / base value, complexes, solvents, and temperature all affect panthenol. This invention discovered that using copper peptides and betaine during the preparation process can mitigate the hydrolysis of panthenol to some extent; on the one hand, by protonating the nucleophile, its nucleophilicity is reduced, thereby inhibiting the reaction. On the other hand, non-covalent interactions interfere with the nucleophilic reaction, creating steric hindrance to alleviate the reaction.

[0070] On the other hand, the present invention stabilizes the overall stability and efficacy of the composition in the base formula by adding surfactants similar to sodium aspartate into the overall formulation.

[0071] The present invention will be further explained below with reference to specific embodiments.

[0072] Example 1

[0073] This embodiment provides a vitamin-based anti-dandruff shampoo composition, the composition comprising:

[0074] Hydroxypropyl cyclodextrin 20 parts, panthenol 10 parts, tocopheryl acetate 5 parts, capryloyl glycine 10 parts, sodium ascorbate phosphate 5 parts, nicotinamide 10 parts, pyridoxine hydrochloride 5 parts, betaine 34.9 parts, tripeptide-1 copper 0.1 parts.

[0075] The preparation method of the vitamin anti-dandruff shampoo composition is as follows:

[0076] S01. Dissolve tocopherol acetate in anhydrous ethanol and disperse evenly.

[0077] S02 Take hydroxypropyl cyclodextrin and dissolve it in deionized water;

[0078] Under the S03 colloid mill conditions, the liquid obtained in step one is slowly added to the liquid obtained in step two, and the equipment is run for 20 minutes after the addition is complete.

[0079] S04 concentrates the mixture obtained in step 3 to recover ethanol, and after spray drying the concentrated paste, adds the remaining components to obtain the final product.

[0080] Another aspect of this embodiment provides a vitamin-based anti-dandruff shampoo, the raw materials of which include:

[0081] 0.1 part of disodium EDTA

[0082] 7 parts of a mixture of sodium lauryl ether sulfate and water (mass ratio 3:7)

[0083] 3 parts of sodium aspartate

[0084] 5 parts of monosodium glutamate

[0085] One part of a mixture of palm kernel oleamide DEA, glycerin, and water (mass ratio 3:1:6).

[0086] A mixture of water, sodium cocoyl methyl taurate, cocamidopropyl betaine, sodium chloride, and sodium benzoate (mass ratio 6:1:1:2:2) 1.5 parts

[0087] Sodium citrate 0.05 parts

[0088] 0.5 parts of a mixture of ammonium lauryl sulfate and water (mass ratio 3:7)

[0089] 0.2 parts of a mixture of hydroxypropyl guar gum, hydroxypropyltrimethylammonium chloride, and water (mass ratio 3:7); 0.05 parts of a mixture of guar gum, hydroxypropyltrimethylammonium chloride, and water (mass ratio 3:7).

[0090] Citric acid 0.05 parts

[0091] 0.15 parts allantoin

[0092] Three parts of a mixture of cocamidopropyl betaine, sodium chloride, sodium benzoate, and water (mass ratio 2:1:1:6).

[0093] 1 part of a mixture of glyceryl laurate, cocamidopropyl betaine, and water (mass ratio 2:2:6); 3 parts of a mixture of sodium cocoaminopropionate and water (mass ratio 2:8).

[0094] 0.25 parts of PPG-3 octyl ether

[0095] A mixture of water, polyquaternium-7, phenoxyethanol, and ethylhexylglycerin (mass ratio 5:2:2:1), 1 part; PEG-7 glyceryl cocoate, 0.15 parts.

[0096] 0.3 parts trehalose

[0097] A mixture of water, hydrolyzed silk, phenoxyethanol, acrylamide propyltrimethylammonium chloride / acrylamide copolymer, and ethylhexylglycerin (mass ratio 5:1:1:1:1:1) 0.3 parts

[0098] 0.1 part of a mixture of methylisothiazolinone, benzyl alcohol, propylene glycol, and water (mass ratio 3:1:1:5).

[0099] 1.55 parts sodium chloride

[0100] Vitamin anti-dandruff shampoo composition (8 parts)

[0101] Water to a final volume of 100 portions.

[0102] The preparation method of the vitamin anti-dandruff shampoo in this embodiment is as follows:

[0103] 1. Add 50% deionized water to a mixing pot, turn on the stirring, and then add the mixture of disodium EDTA, sodium lauryl sulfate and water, and ammonium lauryl sulfate and water in sequence. Stir and heat to 70°C, and stir until completely dissolved and transparent.

[0104] 2. Add palm kernel oleamide DEA, sodium citrate, capryloyl glycine, and allantoin, and stir until completely dissolved and transparent.

[0105] 3. Using 10% deionized water in a clean container, mix the mixture of hydroxypropyl guar gum hydroxypropyl trimethyl ammonium chloride and water evenly, add it to a mixing pot and stir evenly for 5 minutes, then start cooling.

[0106] 4. When the temperature drops to 60℃~55℃, add water, a mixture of sodium cocamidopropyl betaine, sodium chloride, and sodium benzoate in sequence; a mixture of cocamidopropyl betaine, sodium chloride, sodium benzoate, and water; a mixture of sodium cocamidopropyl propionate and water; PPG-3 octyl ether; a mixture of water, polyquaternium-7, phenoxyethanol, and ethylhexylglycerin; PEG-7 glyceryl cocoate; and trehalose, and stir until homogeneous.

[0107] 5. Once the temperature drops below 45℃, add the remaining ingredients (excluding deionized water) to the mixing bowl and stir until well mixed.

[0108] 6. Stop cooling, add the remaining 40% of deionized water, and stir well.

[0109] Example 2

[0110] The difference between this embodiment and Embodiment 1 is that this embodiment provides a vitamin-based anti-dandruff shampoo composition, the composition comprising:

[0111] The ingredients are: 20 parts hydroxypropyl cyclodextrin, 10 parts panthenol, 5 parts tocopheryl acetate, 10 parts capryloyl glycine, 5 parts sodium ascorbate phosphate, 10 parts nicotinamide, 5 parts pyridoxine hydrochloride, 34.9 parts glycerol, and 0.1 parts tripeptide-1 copper. The remaining components are the same as in Example 1.

[0112] Example 3

[0113] The difference between this embodiment and Embodiment 1 is that this embodiment provides a vitamin-based anti-dandruff shampoo composition, the composition comprising:

[0114] The ingredients are: 20 parts hydroxypropyl cyclodextrin, 10 parts panthenol, 5 parts tocopheryl acetate, 10 parts capryloyl glycine, 5 parts sodium ascorbate phosphate, 10 parts nicotinamide, 5 parts pyridoxine hydrochloride, and 34.9 parts betaine. The remaining components are the same as in Example 1.

[0115] Example 4

[0116] The difference between this embodiment and Embodiment 1 is that this embodiment provides a vitamin-based anti-dandruff shampoo composition, the composition comprising:

[0117] The ingredients are: 20 parts hydroxypropyl cyclodextrin, 10 parts panthenol, 5 parts tocopherol acetate, 10 parts capryloyl glycine, 5 parts sodium ascorbate phosphate, 10 parts nicotinamide, 5 parts pyridoxine hydrochloride, and 34.9 parts glycerol. The remaining components are the same as in Example 1.

[0118] Example 5

[0119] The difference between this embodiment and Embodiment 1 is that this embodiment provides a vitamin-based anti-dandruff shampoo composition, the composition comprising:

[0120] The ingredients are: 20 parts hydroxypropyl cyclodextrin, 10 parts panthenol, 5 parts tocopheryl acetate, 10 parts capryloyl glycine, 5 parts sodium ascorbate phosphate, 10 parts nicotinamide, 5 parts pyridoxine hydrochloride, 20 parts betaine, 14.9 parts glycerol, and 0.1 parts tripeptide-1 copper. The remaining components are the same as in Example 1.

[0121] Example 6

[0122] The difference between this embodiment and Embodiment 1 is that this embodiment provides a vitamin-based anti-dandruff shampoo composition, the composition comprising:

[0123] 20 parts hydroxypropyl cyclodextrin, 10 parts panthenol, 5 parts tocopheryl acetate, 10 parts capryloyl glycine, 5 parts sodium ascorbate phosphate, 10 parts nicotinamide, 5 parts pyridoxine hydrochloride, 40 parts betaine, and 0.1 parts tripeptide-1 copper. The remaining components are the same as in Example 1.

[0124] Example 7

[0125] The difference between this embodiment and Embodiment 1 is that the preparation method of the vitamin anti-dandruff shampoo composition is as follows: simply stir and mix all the compositions evenly.

[0126] The rest is the same as in Example 1.

[0127] Example 8

[0128] The difference between this embodiment and Embodiment 1 is that this embodiment provides a vitamin-based anti-dandruff shampoo, the raw materials of which include:

[0129] 0.1 part of disodium EDTA

[0130] 15 parts of a mixture of sodium lauryl ether sulfate and water (mass ratio 3:7)

[0131] One part of a mixture of palm kernel oleamide DEA, glycerin, and water (mass ratio 3:1:6).

[0132] A mixture of water, sodium cocoyl methyl taurate, cocamidopropyl betaine, sodium chloride, and sodium benzoate (mass ratio 6:1:1:2:2) 1.5 parts

[0133] Sodium citrate 0.05 parts

[0134] 0.5 parts of a mixture of ammonium lauryl sulfate and water (mass ratio 3:7)

[0135] 0.2 parts of a mixture of hydroxypropyl guar gum, hydroxypropyltrimethylammonium chloride, and water (mass ratio 3:7); 0.05 parts of a mixture of guar gum, hydroxypropyltrimethylammonium chloride, and water (mass ratio 3:7).

[0136] Citric acid 0.05 parts

[0137] 0.15 parts allantoin

[0138] Three parts of a mixture of cocamidopropyl betaine, sodium chloride, sodium benzoate, and water (mass ratio 2:1:1:6).

[0139] One part of a mixture of glyceryl laurate, cocamidopropyl betaine, and water (mass ratio 2:2:6)

[0140] 3 parts of a mixture of sodium cocoylaminopropionate and water (mass ratio 2:8)

[0141] 0.25 parts of PPG-3 octyl ether

[0142] 1 part of a mixture of water, polyquaternium-7, phenoxyethanol, and ethylhexylglycerin (mass ratio 5:2:2:1)

[0143] 0.15 parts of PEG-7 glyceryl cocoate

[0144] 0.3 parts trehalose

[0145] A mixture of water, hydrolyzed silk, phenoxyethanol, acrylamide propyltrimethylammonium chloride / acrylamide copolymer, and ethylhexylglycerin (mass ratio 5:1:1:1:1:1) 0.3 parts

[0146] 0.1 part of a mixture of methylisothiazolinone, benzyl alcohol, propylene glycol, and water (mass ratio 3:1:1:5).

[0147] 1.55 parts sodium chloride

[0148] Vitamin anti-dandruff shampoo composition (8 parts)

[0149] Water to a final volume of 100 portions.

[0150] Performance testing

[0151] Test 1: Shampoos from Examples 1-8 were placed in constant temperature incubators at 48℃, 5℃, and 25℃ respectively. After 30 days, the samples were brought back to room temperature, and their appearance was observed to determine if there were any changes. A 5℃-45℃ thermal cycling test was conducted for two cycles. The test results are shown in Table 1.

[0152] Table 1 Performance Test Results

[0153]

[0154]

[0155] Test 2: The panthenol content was determined using HPLC, and the content was measured every month for 8 months. The panthenol content obtained from the tests is shown in Table 2 below. The retention rate is obtained by dividing the test results by the initial panthenol results.

[0156] Table 2 Test Results

[0157]

[0158] Test 3: Combing Test: By conducting friction work test and gloss test on hair strands before and after sample treatment, the effect of the test sample on improving the friction work and gloss of hair strands is evaluated, and the repair efficacy of the product is verified.

[0159] friction

[0160] The frictional work done on the hair strands before and after using the sample was measured using a precise force sensor on a combing device. The degree of reduction in frictional work was used to measure the effectiveness of the sample in repairing the hair strands. The less frictional work was done, the smoother the hair strands were.

[0161] Materials: Black, damaged, flat hair strands, 15cm long, 3.0g

[0162] Testing instruments: hair comber, electronic balance.

[0163] Environmental requirements: Temperature: 21.0℃±1.0℃; Humidity: 50%±10%

[0164] Friction test

[0165] 1. Randomly select 5 identical flat hair bundles (3.0g, 15cm, damaged hair bundles) and equilibrate them in a constant temperature and humidity environment [(21±1)℃, (50±10)%RH] for 24 hours;

[0166] 2. Use a hair combing device to test the friction work done by 5 hair strands, once for each strand, and record the friction work value (before treatment);

[0167] 3. After washing the hair bundles, wipe off excess water. Take a sample of 0.1g / g of hair from each bundle and apply it to the hair strands. Leave the sample on for 1 minute, then rinse with running water for 30 seconds. Repeat this process once. Place the detached hair in a constant temperature and humidity environment [(21±1)℃, (50±10)%RH] to air dry naturally for 24 hours.

[0168] 4.24 hours later, the friction work done by the hair strand was measured again using a hair strand combing instrument (after processing).

[0169] Use Excel to perform descriptive statistics on data, including mean and standard deviation.

[0170] Use SPSS software to test the significance of the normal distribution of the data. If the sample group data Sig. (two-tailed) > 0.05, then it is normally distributed, and a paired-samples t-test is performed with a significance level of α = 0.05; otherwise, a rank-sum test is performed.

[0171] The test results are shown in Table 3.

[0172] Table 3 shows the test results of performance test 3.

[0173]

[0174]

[0175] Test 4: Dandruff Removal Performance Test

[0176] The products prepared in Examples 1 to 8 were subjected to a dandruff questionnaire test. Forty subjects were selected, aged between 20 and 45 years, including 10 males and 30 females.

[0177] The questionnaire content is shown in Table 4.

[0178] Table 4. Questionnaire content of participants in the dandruff treatment program.

[0179]

[0180] A score of 5 indicates complete agreement, 4 indicates moderate agreement, 3 indicates both agreement and disagreement (neutral), 2 indicates moderate disagreement, and 1 indicates complete disagreement. The result is a composite score of the 40 rankings.

[0181] Table 5. Results of the questionnaire for participants with dandruff.

[0182]

[0183]

[0184] Test 5: 5α-Reductase Inhibition Rate Test: Accurately weigh Sample 1, dilute Sample 1 to a 2% solution, and react it with the 5α-reductase solution. A negative control and a blank control were also included. The OD value was measured according to the test kit procedure. The 5α-reductase content was determined based on the standard curve. The 5α-reductase inhibition rate was calculated. Formula: Inhibition rate (%) = (1 – T / C) × 100, where T – 5α-reductase content in the sample solution; C – 5α-reductase content in the negative control. The test showed that the inhibition rate of Example 1 was 68.32%, and the enzyme content in the sample group was significantly lower than that in the negative control, demonstrating excellent 5α-reductase inhibition rate.

[0185] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A vitamin-based anti-dandruff shampoo, characterized in that, The raw materials for its preparation include: 0.1 parts disodium EDTA, a mixture of sodium lauryl ether sulfate and water in a mass ratio of 3:7; 7 parts sodium aspartate, 3 parts sodium glutamate, 5 parts palm kernel oleamide DEA, glycerin, and water in a mass ratio of 3:1:6; 1 part a mixture of water, sodium cocoyl methyl taurate, cocamidopropyl betaine, sodium chloride, and sodium benzoate in a mass ratio of 6:1:1:2:2; 1.5 parts sodium citrate, 0.05 parts ammonium lauryl sulfate, and water in a mass ratio of 3:7; and 0.5 parts a mixture of hydroxypropyl guar gum, hydroxypropyl trimethylammonium chloride, and water. A mixture of guar gum (3:7 by mass), 0.2 parts of hydroxypropyltrimethylammonium chloride, and water; a mixture of citric acid (0.05 parts), allantoin (0.15 parts), cocamidopropyl betaine, sodium chloride, sodium benzoate, and water (2:1:1:6 by mass), 3 parts of glyceryl laurate, cocamidopropyl betaine, and water (2:2:6 by mass), 1 part of sodium cocoaminopropionate, and water (2:8 by mass), and 3 parts of PPG-3. The composition comprises: 0.25 parts octyl ether, a mixture of water, polyquaternium-7, phenoxyethanol, and ethylhexylglycerin in a mass ratio of 5:2:2:1; 1 part PEG-7 glyceryl cocoate; 0.15 parts trehalose; 0.3 parts water, hydrolyzed silk, phenoxyethanol, acrylamide propyltrimethylammonium chloride / acrylamide copolymer, and ethylhexylglycerin in a mass ratio of 3:1:1:5; 0.1 parts sodium chloride; 1.55 parts vitamin anti-dandruff shampoo composition; 8 parts water, with the remainder to 100 parts; the vitamin anti-dandruff shampoo composition comprises: 20 parts hydroxypropyl cyclodextrin, 10 parts panthenol, 5 parts tocopheryl acetate, 10 parts capryloyl glycine, 5 parts sodium ascorbate phosphate, 10 parts nicotinamide, 5 parts pyridoxine hydrochloride, 34.9 parts betaine, and 0.1 parts tripeptide-1 copper.

2. The method for preparing a vitamin-based anti-dandruff shampoo according to claim 1, characterized in that, The preparation method is as follows: (1) Add 50% deionized water to a stirring pot, turn on the stirring, and add EDTA in sequence. (1) A mixture of disodium lauryl sulfate, sodium lauryl sulfate and water, and a mixture of ammonium lauryl sulfate and water, are stirred and heated to 70°C until completely dissolved and transparent; (2) Palm kernel oleamide DEA, sodium citrate, capryloyl glycine, and allantoin are added and stirred until completely dissolved and transparent; (3) Using 10% deionized water alone, in a clean bucket, a mixture of hydroxypropyl guar gum hydroxypropyl trimethyl ammonium chloride and water, and a mixture of guar gum hydroxypropyl trimethyl ammonium chloride and water are dispersed evenly, added to a mixing pot and stirred evenly for 5 minutes, and then the temperature is lowered; (4) When the temperature drops to 60°C to 55°C, a mixture of water, sodium cocoyl methyl taurate, cocamidopropyl betaine, sodium chloride, and sodium benzoate are added in sequence; a mixture of cocamidopropyl betaine, sodium chloride, sodium benzoate, and water; a mixture of sodium cocoyl aminopropionate and water; PPG-3 Octyl ether; a mixture of water, polyquaternium-7, phenoxyethanol, and ethylhexylglycerin; PEG-7 glyceryl cocoate; trehalose; (5) when the temperature drops below 45°C, add the remaining raw materials (after removing deionized water) to the mixing pot and stir evenly; (6) when the temperature drops, add the remaining 40% deionized water and stir evenly.

3. The use of the vitamin anti-dandruff shampoo according to claim 1 in the preparation of daily chemical products.

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