A composition, preparation method and application of plateau anti-hypoxia functional extract

Abstract

The present invention belongs to the technical field of food additives, and specifically relates to a composition, preparation method and application of a plateau anti-hypoxia functional extract, which is composed of S-NAD+ (broccoli extract), walnut extract, Cistanche extract, mulberry leaf extract, grape skin extract, angelica extract, polygonatum extract, astragalus extract and chamomile extract. The composition of plateau anti-hypoxia functional extract prepared by this technical solution can improve the user's capillary dilation, hemoglobin oxygen carrying capacity, improve mitochondrial metabolism, reduce oxidative stress, etc., improve blood oxygen saturation, improve anti-hypoxia ability, and reduce the impact of plateau hypoxia on different tissues and organs of the body.

Description

Technical Field

[0001] The invention belongs to the technical field of food additives, and specifically relates to a composition, a preparation method and application of a plateau anti-hypoxia functional extract. Background Art

[0002] Low pressure and low oxygen are the main environmental factors in plateau areas and the main pathogenic factors of altitude sickness. With the increasing number of people working and traveling in the plateau, the health maintenance of people entering the plateau area has attracted more and more attention and has become an important direction for the research of plateau drugs or health products.

[0003] At present, there are many studies on drugs for altitude sickness, and corresponding results have been achieved, but these drugs can only be used for patients who have already developed altitude sickness. According to the view of traditional medicine, preventing disease before it occurs is the highest level in the medical field. How to prevent altitude sickness in advance is far better than treating it, and it can effectively avoid damage to the human body caused by altitude sickness. Summary of the invention

[0004] The purpose of the present invention is to provide a composition, preparation method and application of a plateau anti-hypoxia functional extract, which is prepared into a food through a composite formula of multiple natural active ingredients. It is aimed at people before entering or already entering the plateau, and acts on capillary dilation, hemoglobin oxygen carrying capacity, improving mitochondrial metabolism, reducing oxidative stress, etc., to improve blood oxygen saturation, improve anti-hypoxia ability, and reduce the impact of plateau hypoxia on different tissues and organs of the body, so as to solve the problems existing in the above-mentioned background technology.

[0005] To achieve the above objectives, this application is implemented through the following technical solutions:

[0006] A composition of plateau anti-hypoxia functional extracts, consisting of S-NAD+ (broccoli extract), walnut extract, Cistanche deserticola extract, mulberry leaf extract, grape skin extract, angelica extract, polygonatum extract, astragalus extract and chamomile extract.

[0007] Furthermore, by weight percentage, it comprises 0.1-0.3% S-NAD+ (broccoli extract), 1-5% Cistanche extract, 5-10% mulberry leaf extract, 2-5% grape skin extract, 20-30% angelica extract, 5-15% polygonatum extract, 15-20% astragalus extract, 5-10% chamomile extract and the remainder walnut extract.

[0008] Furthermore, by weight percentage, it comprises 0.1-0.2% S-NAD+ (broccoli extract), 3-5% Cistanche extract, 8-10% mulberry leaf extract, 3-5% grape skin extract, 25-28% angelica extract, 8-12% polygonatum extract, 18-20% astragalus extract, 5-8% chamomile extract and the remainder walnut extract.

[0009] Furthermore, the Cistanche deserticola extract, Angelica sinensis extract, Polygonatum sibiricum extract and Astragalus membranaceus extract are all butylene glycol extracts after ethanol extraction.

[0010] Furthermore, the polygonatum extract and the astragalus extract are specifically the liquid after boiling in water, which is extracted with ethanol to obtain the corresponding ethanol extract, and then the ethanol extract is extracted with butanediol to obtain the corresponding polygonatum extract and astragalus extract.

[0011] Furthermore, the invention also comprises 3-8% by weight of onion extract and 10-15% by weight of codonopsis pilosula extract.

[0012] Furthermore, the invention also comprises 1-3% by weight of turmeric extract, 1-3% by weight of ginger extract and 0.5-1% by weight of white pepper extract.

[0013] Furthermore, it also includes 0.001-0.003% vitamin B1 and 0.001-0.005% vitamin B2 by weight.

[0014] The preparation method of the composition of any of the above-mentioned plateau anti-hypoxia functional extracts comprises mixing the above-mentioned components evenly according to proportions and pressing the components into a set shape.

[0015] An application is the application of any one of the above-mentioned high altitude anti-hypoxia functional extract compositions in an anti-altitude reaction product.

[0016] The beneficial effects of the present invention are:

[0017] The plateau anti-hypoxia functional extract prepared by the present technical solution can improve the user's capillary dilation, hemoglobin oxygen carrying capacity, improve mitochondrial metabolism, reduce oxidative stress, etc., increase blood oxygen saturation, improve anti-hypoxia ability, and reduce the impact of plateau hypoxia on different tissues and organs of the body. DETAILED DESCRIPTION

[0018] The technical solution of the present invention is described in detail below through examples. The following examples are merely exemplary and can only be used to explain and illustrate the technical solution of the present invention, but cannot be construed as limiting the technical solution of the present invention.

[0019] Among the components used in this application, S-NAD+ (nicotinamide riboside sulfide) is present in broccoli extract; the amount of NAD+ (oxidized Nicotinamide Adenine Dinucleotide, nicotinamide adenine dinucleotide, abbreviated as: coenzyme I) in cells is directly related to aging.

[0020] Mulberry leaf extract, chamomile extract, walnut extract, onion extract, codonopsis extract, turmeric extract, ginger extract, white pepper extract, vitamin B1 and vitamin B2 are all obtained through commercial channels.

[0021] The Cistanche extract is prepared by soaking the Cistanche in 95% ethanol for 48-120 hours, soaking the solid in 75% ethanol for 36-72 hours, and further soaking the solid in 50% ethanol for 120 hours, collecting the above ethanol solution and then separating the ethanol to obtain the ethanol extract of Cistanche, and then dissolving the ethanol extract of Cistanche in butylene glycol and standing for 24 hours, separating the butylene glycol solution and then separating the butylene glycol, and the obtained product is the Cistanche extract used in this application.

[0022] Likewise, the preparation method of the Angelica extract of the present application is the same as the preparation method of the Cistanche deserticola extract.

[0023] In the present application, the polygonatum extract is specifically a liquid after boiling in water (the same as the current Chinese medicine boiling), specifically, it is boiled in water three times, the decoctions after three boilings are mixed, and the conventional vacuum concentration technology is used to perform vacuum concentration to obtain a polygonatum concentrate, the polygonatum concentrate is stirred and dissolved with ethanol, and allowed to stand for 24-48 hours to obtain an upper ethanol solution, butanediol is added to the ethanol solution for extraction, and then the butanediol in the butanediol solution is separated to obtain the polygonatum extract.

[0024] Likewise, the preparation method of the Astragalus extract is the same as the preparation method of the Polygonatum sibiricum extract.

[0025] Example 1

[0026] The composition of the plateau anti-hypoxia functional extract of this embodiment is composed of 0.1% S-NAD+ (broccoli extract), 2% Cistanche extract, 5% mulberry leaf extract, 2% grape skin extract, 20% angelica extract, 5% polygonatum extract, 15% astragalus extract, 5% chamomile extract and the remainder walnut extract by weight percentage.

[0027] After the above components are evenly mixed and pressed, the plateau anti-hypoxia functional extract is obtained.

[0028] Example 2

[0029] The composition of the plateau anti-hypoxia functional extract of this embodiment is composed of 0.3% S-NAD+ (broccoli extract), 5% Cistanche extract, 10% mulberry leaf extract, 5% grape skin extract, 30% angelica extract, 15% polygonatum extract, 20% astragalus extract, 10% chamomile extract and the remainder walnut extract by weight percentage.

[0030] The preparation method is the same as that in Example 1.

[0031] Example 3

[0032] The composition of the plateau anti-hypoxia functional extract of this embodiment is composed of 0.2% S-NAD+ (broccoli extract), 3% Cistanche extract, 8% mulberry leaf extract, 4% grape skin extract, 28% angelica extract, 10% polygonatum extract, 20% astragalus extract, 8% chamomile extract and the remainder walnut extract by weight percentage.

[0033] The preparation method is the same as that in Example 1.

[0034] Example 4

[0035] The composition of the plateau anti-hypoxia functional extract of this embodiment is composed by weight percentage of 0.25% S-NAD+ (broccoli extract), 3% Cistanche extract, 6% mulberry leaf extract, 3% grape skin extract, 23% angelica extract, 10% polygonatum extract, 15% astragalus extract, 5% chamomile extract, 4% onion extract, 10% codonopsis extract and the remainder walnut extract.

[0036] The preparation method is the same as that in Example 1.

[0037] Example 5

[0038] The composition of the plateau anti-hypoxia functional extract of this embodiment is composed of 0.3% S-NAD+ (broccoli extract), 5% Cistanche extract, 7% mulberry leaf extract, 5% grape skin extract, 25% angelica extract, 10% polygonatum extract, 18% astragalus extract, 5% chamomile extract, 8% onion extract, 12% codonopsis extract and the remainder walnut extract by weight percentage.

[0039] The preparation method is the same as that in Example 1.

[0040] Example 6

[0041] The composition of the plateau anti-hypoxia functional extract of this embodiment consists of 0.25% S-NAD+ (broccoli extract), 3% Cistanche extract, 6% mulberry leaf extract, 3% grape skin extract, 23% angelica extract, 10% polygonatum extract, 15% astragalus extract, 5% chamomile extract, 4% onion extract, 10% codonopsis extract, 1% turmeric extract, 1% ginger extract, 0.5% white pepper extract and the remainder walnut extract, by weight percentage.

[0042] The preparation method is the same as that in Example 1.

[0043] Example 7

[0044] The composition of the plateau anti-hypoxia functional extract of this embodiment consists of 0.25% S-NAD+ (broccoli extract), 3% Cistanche extract, 6% mulberry leaf extract, 3% grape skin extract, 23% angelica extract, 10% polygonatum extract, 20% astragalus extract, 5% chamomile extract, 4% onion extract, 10% codonopsis extract, 2% turmeric extract, 1% ginger extract, 1% white pepper extract and the remainder walnut extract.

[0045] The preparation method is the same as that in Example 1.

[0046] Example 8

[0047] The composition of the plateau anti-hypoxia functional extract of this embodiment consists of 0.25% S-NAD+ (broccoli extract), 3% Cistanche extract, 6% mulberry leaf extract, 3% grape skin extract, 23% angelica extract, 10% polygonatum extract, 20% astragalus extract, 5% chamomile extract, 4% onion extract, 10% codonopsis extract, 2% turmeric extract, 1% ginger extract, 1% white pepper extract, 0.001% vitamin B1, 0.002% vitamin B2 and the remainder walnut extract, by weight percentage.

[0048] The preparation method is the same as that in Example 1.

[0049] Example 9

[0050] The composition of the plateau anti-hypoxia functional extract of this embodiment consists of 0.25% S-NAD+ (broccoli extract), 3% Cistanche extract, 6% mulberry leaf extract, 3% grape skin extract, 23% angelica extract, 10% polygonatum extract, 15% astragalus extract, 5% chamomile extract, 4% onion extract, 10% codonopsis extract, 1% turmeric extract, 1% ginger extract, 0.5% white pepper extract, 0.002% vitamin B1, 0.003% vitamin B2 and the remainder walnut extract, by weight percentage.

[0051] The preparation method is the same as that in Example 1.

[0052] 2023 Tibet test results:

[0053] On March 6, 2023, Lhasa is 3635m above sea level and has an air pressure of 646hpa (test tool: Casio prw02500T-7).

[0054] Tester 1, female, 48 years old, had previously traveled from Linzhi to Lhasa by train on February 8, 2023, and had mild headache symptoms.

[0055] Tester 2, male, 49 years old, had been to Lhasa several times before and had basically no reaction.

[0056] On March 7, 2023, the two testers drove from Lhasa to the Yarlung Zangbo River Valley (3960m above sea level) and Yamdrok Lake (4670m above sea level, air pressure 565hpa, testing tool Casio prw02500T-7).

[0057] Tester 1: Severe headache, weak energy during exercise, head feels like it’s being squeezed, basically unable to move or communicate in the car.

[0058] Test subject 2 felt chest tightness and shortness of breath while walking near Yamdrok Lake.

[0059] At the Karola Glacier, the altitude is 5000m and the air pressure is 548hpa.

[0060] Tester 1: Did not get off the car, but breathed oxygen in the car. His movements were restricted when he got off the car without oxygen, and he got a headache immediately when he exercised. He breathed oxygen immediately. He took 1 capsule of this product during the journey.

[0061] Tester 2: Took 1 capsule of this product before climbing. During the climbing process, he felt chest tightness, shortness of breath, and slightly weak legs. He could not exercise normally and needed to rest in between.

[0062] On March 8, 2023, the participants returned to Lhasa via the Donggula and Dangxiong routes with an average altitude of over 4,000 meters. Before departure, tester 1 and tester 2 each took one capsule of this product.

[0063] During the trip, the altitude was about 4000m. Tester 1 was arranged to take 1 capsule of this product every 2 hours. He did not breathe oxygen during the trip, felt a slight headache, and did not get off the car to exercise. Tester 2 did not take the capsule of this product during the trip.

[0064] At an altitude of 5,400 meters, tester 1 took one capsule of this product and did not participate in climbing. During the climbing process, tester 2 felt headache, chest tightness, shortness of breath, weak legs, and difficulty walking at an altitude of 5,430 meters. He took two capsules of this product and felt significantly improved 10 minutes later. He was able to move and his altitude sickness was reduced. When he reached an altitude of 5,460 meters, he had no special reaction.

[0065] Through actual testing, it was preliminarily determined that the dosage should be determined according to the altitude: 1 tablet / day below 2000m above sea level, 2 tablets / day at 2000-3000m above sea level, 3 tablets / day at 3000-4000m above sea level, 4-5 tablets / day at 4000-5000m above sea level. The dosage should be appropriately supplemented according to the length of time at high altitude and the amount of exercise, 4-5 tablets / day above 5000 meters.

[0066] The above are only preferred embodiments of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A composition of plateau anti-hypoxia functional extracts, characterized in that: It is composed of S-NAD+, walnut extract, Cistanche extract, mulberry leaf extract, grape skin extract, angelica extract, Polygonatum sibiricum extract, Astragalus extract and chamomile extract.

2. The composition of the plateau anti-hypoxia functional extract according to claim 1, characterized in that: By weight percentage, it comprises 0.1-0.3% S-NAD+, 1-5% Cistanche extract, 5-10% mulberry leaf extract, 2-5% grape skin extract, 20-30% angelica extract, 5-15% polygonatum extract, 15-20% astragalus extract, 5-10% chamomile extract and the remainder walnut extract.

3. The composition of the plateau anti-hypoxia functional extract according to claim 2, characterized in that: By weight percentage, it comprises 0.1-0.2% S-NAD+, 3-5% Cistanche extract, 8-10% mulberry leaf extract, 3-5% grape skin extract, 25-28% angelica extract, 8-12% polygonatum extract, 18-20% astragalus extract, 5-8% chamomile extract and the remainder walnut extract.

4. The composition of the plateau anti-hypoxia functional extract according to claim 1, characterized in that: The Cistanche deserticola extract, Angelica sinensis extract, Polygonatum sibiricum extract and Astragalus membranaceus extract are all butylene glycol extracts extracted with ethanol.

5. The composition of the plateau anti-hypoxia functional extract according to claim 1, characterized in that: The polygonatum sibiricum extract and the astragalus radix extract are specifically the liquid after boiling in water, which is extracted with ethanol to obtain the corresponding ethanol extract, and then the ethanol extract is extracted with butanediol to obtain the corresponding polygonatum sibiricum extract and astragalus radix extract.

6. The composition of the plateau anti-hypoxia functional extract according to claim 2, characterized in that: The invention also comprises 3-8% by weight of onion extract and 10-15% by weight of codonopsis pilosula extract.

7. The composition of the plateau anti-hypoxia functional extract according to claim 6, characterized in that: The invention also comprises 1-3% of turmeric extract, 1-3% of ginger extract and 0.5-1% of white pepper extract by weight.

8. The composition of high altitude anti-hypoxia functional extract according to claim 7, characterized in that: It also contains 0.001-0.003% vitamin B1 and 0.001-0.005% vitamin B2 by weight.

9. A method for preparing a composition of a high-altitude anti-hypoxia functional extract according to any one of claims 1 to 8, characterized in that: The above components are mixed evenly according to proportion and pressed into a set shape.

10. An application, comprising the composition of the plateau anti-hypoxia functional extracts according to any one of claims 1 to 8 in an anti-altitude reaction product.