Cypermethrin insecticide composition

Abstract

The present invention relates to a novel liquid insecticide composition, which comprises 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, wherein the total trans isomer (1R, 3S and 1S, 3R are almost equal) content ranges from 90% to 99.90% and the total cis isomer (1R, 3R and 1S, 3S are almost equal) content ranges from 0.1% to 10%, or "cyfluthrin" as an active ingredient; and one or more chemically acceptable excipients. The present invention also relates to a preparation method of the liquid insecticide composition.

Description

Technical Field

[0001] The present invention relates to a novel insecticidal composition comprising a pyrethroid insecticide as an active ingredient. Specifically, the present invention relates to a novel and effective liquid insecticidal composition comprising cyfluthrin as an active ingredient, wherein the composition exhibits significant mosquito repellent and insect control activity. The present invention also relates to a method for preparing the insecticidal composition. Background Art

[0002] The mosquito menace is a global problem. Diseases like malaria, filariasis, dengue fever, yellow fever, Japanese encephalitis, Ross River virus, Burmese forest virus, Murray Valley encephalitis are known to be transmitted through mosquitoes. Even in developed countries like the United States, the mosquito menace and diseases like West Nile virus have made a comeback in the 21st century. Developing and least developed countries from Africa, Asia, Latin America, and other parts of the world have been trying to control the mosquito menace and eradicate the scourge of malaria and other diseases but all without success.

[0003] Insecticides of various compounds, such as pyrethroids, organophosphates, carbamates, etc., are used to control pest species. These chemicals are included as active ingredients in the composition of insecticide products. Such insecticide mite preparations are available in the following forms: aerosols in containers, ready-to-use liquids in non-propellant packaging, dusts, wettable powders, soluble powders, tablets and granules, emulsions and their concentrates (coarse, micro, suspoemulsions, flowables and microcapsules), various baits, bait stations, sticky traps, electric heaters with mosquito nets and liquid vaporizers, coils, spirals, incense, crayons, gels, creams, lotions, shampoos, etc.

[0004] Pyrethrins are insecticides of natural origin with very good properties, such as high insecticide activity and very low toxicity to mammals. However, natural pyrethrins are easily oxidized by air in the presence of light (photooxidation) and are easily degraded, making them unsuitable for insecticidal applications.

[0005] A number of compounds have been synthesized that slightly modify the structure of natural pyrethrins to retain insecticidal activity and low mammalian toxicity while rendering the molecules sufficiently photostable to enable their use in insecticidal applications.

[0006] Although some of these compounds (synthetic pyrethroids) have the above-mentioned properties, the liquid vaporizing compositions conventionally used may have high photo-oxidative properties and act at permanently high active concentrations. Liquid vaporizers are designed to work in closed spaces, so the risk of exposure to such large amounts of insecticidal compositions can be considered a risk to the health of the user. Therefore, it is necessary to formulate suitable compositions that are effective and safe.

[0007] Recently, the inventors of IN316787 developed a new active ingredient 'Cyfluthrin', which was found to be effective as a household insecticide. The study found that Cyfluthrin can be effectively and practically used in existing known formulation types, and also has the potential to be suitable for the development of new formulations and delivery systems. The active ingredient 'Cyfluthrin' is an isomeric composition of 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, wherein the total trans isomer (1R, 3S and 1S, 3R are almost equal in content) ranges from 90% to 99.90%, and the total cis isomer (1R, 3R and 1S, 3S are almost equal in content) ranges from 0.1 to 10%. To date, there is a need in the art to formulate a liquid insecticide composition that is safer to use and economically advantageous. These objects can be achieved by providing an insecticide composition which can achieve improved knockdown efficacy with lower amounts of active agent compared to conventionally used insecticides.

[0008] Therefore, the object of the present invention is to overcome the problems existing in the prior art and provide a stable and effective liquid insecticide composition with cypermethrin as an active ingredient. Summary of the invention

[0009] The main object of the present invention is to provide a novel and effective insecticidal composition containing cyfluthrin.

[0010] Another object of the present invention is to provide a novel and effective insecticidal composition which can be used to kill, knock down and / or repel mosquitoes and insects.

[0011] Another object of the present invention is to provide a novel, effective and safe insecticidal composition.

[0012] Another object of the present invention is to provide a novel and effective composition which exhibits low inhalation toxicity.

[0013] Yet another object of the present invention is to provide a novel and effective insecticidal composition which is easy to formulate.

[0014] Another object of the present invention is to provide a novel and effective "ready-to-use" insecticidal composition.

[0015] Another object of the present invention is to provide a novel and effective insecticidal composition which is economically preferred.

[0016] Another object of the present invention is to provide a novel and effective insecticidal composition which uses lower concentrations of active substances compared to conventional formulations.

[0017] Still another object of the present invention is to provide a novel and effective insecticidal composition which exhibits better knockdown efficacy than conventionally known insecticidal compositions.

[0018] It is another object of the present invention to provide an even fade out of the insecticidal composition through the core.

[0019] It is another object of the present invention to provide a novel effective insecticidal composition for use with a dispensing device, wherein the dispensing device is selected from the group consisting of an electric heating device, a piezoelectric diffuser, a liquid vaporizer, and an ambient dispensing device.

[0020] Another object of the present invention is to provide a novel and effective insecticidal composition against flying and crawling insects.

[0021] Another object of the present invention is to develop a liquid insecticidal composition which is effective against all mosquito species including but not limited to Aedes, Culex, Anopheles, Echinops and many other species of crawling insects and flies such as Aedes (Phlebotomus), sand flies, house flies (Malva sericata etc.), stable flies and face flies etc., which pose a threat to human health.

[0022] It is a further object of the present invention to provide a novel and effective insecticidal composition which is stable when stored at room temperature.

[0023] Some or all of the above objects of the present invention, as well as other objects, can be achieved by the present invention described below.

[0024] Therefore, the present invention relates to a novel and effective insecticidal composition comprising:

[0025] a) cyfluthrin; and

[0026] b) one or more chemically acceptable excipients.

[0027] In one embodiment of the present invention, the pesticidal composition comprises:

[0028] a) cyfluthrin in an amount of 0.01% to 5% by weight of the total composition; and

[0029] b) one or more chemically acceptable excipients.

[0030] In another embodiment, the present invention provides a method for preparing an insecticidal composition, comprising:

[0031] a) cyfluthrin is present in an amount of 0.01% to 5% by weight of the total composition; and

[0032] b) one or more chemically acceptable excipients.

[0033] In yet another preferred embodiment, the insecticidal composition comprises cyfluthrin in an amount of 0.2% to 2.0% by weight of the total composition.

[0034] In another embodiment, the present invention provides a method for preparing an insecticidal liquid composition from the mefenacet industrial agent.

[0035] In yet another embodiment, the present invention provides a method for preparing an insecticidal liquid composition from MUPs comprising mefenacet.

[0036] In another preferred embodiment, the present invention provides a method for preparing an insecticidal liquid composition from MUP containing 5% of mefenacet.

[0037] In another preferred embodiment of the present invention, the insecticidal composition comprises cyfluthrin or 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate as an active ingredient, wherein the content of total trans isomers (1R, 3S and 1S, 3R are almost equal) is 90% to 99.90%, and the content of total cis isomers (1R, 3R and 1S, 3S are almost equal) is 0.1% to 10%.

[0038] In another embodiment of the present invention, the insecticidal composition of the present invention is used to kill, knock down and / or repel mosquitoes and insects.

[0039] In yet another embodiment of the present invention, the insecticidal composition of the present invention can be formulated as a composition that is emitted by a heat source, a liquid vaporizer composition, an electric liquid vaporizer composition, a wicked insect repellent liquid vaporizer composition, and the like.

[0040] In another embodiment of the present invention, the insecticidal composition requires a wick which, when heated, vaporizes the insecticidal composition and releases the insect repellent composition into the air.

[0041] In another embodiment of the present invention, the insecticidal composition of the present invention is a ready-to-use formulation for repelling / controlling mosquitoes and insects in indoor spaces. DETAILED DESCRIPTION

[0042] Discussed below are some representative embodiments of the present invention. The present invention in its broader aspects is not limited to specific details and representative methods. Illustrative examples are described in conjunction with the provided embodiments and methods in this embodiment. In view of this specification and appropriate equivalents, the present invention according to its various aspects is particularly pointed out.

[0043] All technical and scientific terms used in the present invention have the same meaning as commonly understood by one of ordinary skill in the art to which the subject matter belongs. It should be noted that the singular forms "a", "an", and "the" used in the specification include plural referents unless the context clearly indicates otherwise. Thus, for example, reference to a composition containing "a compound" includes a mixture of two or more compounds. It should also be noted that the term "or" is generally used in its sense including "and / or" unless the context clearly indicates otherwise.

[0044] Unless otherwise indicated, various amounts expressed as "% w / w" or "%" refer to weight percent relative to the weight of the total formulation or composition.

[0045] The term "insect" as used herein refers to flying and / or crawling insects and other insects in the field of public health, including but not limited to all species of mosquitoes, house flies, sand flies, stable flies and face flies.

[0046] The term "control" as used in the present invention means killing, knocking down and / or repelling mosquitoes, other insects and flies.

[0047] The term "active ingredient" (ai) or "active agent" as used herein refers to the component of the composition responsible for controlling and killing mosquitoes, other insects and flies.

[0048] The term "fluthrin, also abbreviated as RNF" used in the present invention refers to 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, wherein the total trans isomer content (1R, 3S and 1S, 3R contents are almost equal) ranges from 90% to 99.90%, and the total cis isomer content (1R, 3R and 1S, 3S contents are almost equal) ranges from 0.1 to 10%.

[0049] The term "trans" used in the present invention refers to (1R, 3S) and (1S, 3R).

[0050] The term "cis" as used in the present invention refers to (1R, 3R) and (1S, 3S).

[0051] The terms "formulation" and "composition" used in the present invention express the same meaning and can be used interchangeably.

[0052] The term "knockdown" as used herein refers to the knockdown of insects following application of an insecticide, which can be defined as a state of intoxication and partial paralysis that usually precedes death.

[0053] The term "MUP" as used in this embodiment refers to any pesticide product other than the final use product. The product may consist of only technical grade active ingredients or may contain inert ingredients such as stabilizers or solvents.

[0054] The term "RTU" as used in the present invention refers to a ready-to-use formulation.

[0055] The term "Pitt-Grady chamber test" as used herein refers to a standardized procedure for evaluating and testing insect control compositions or products. For flying insects, the percentage knockdown is determined after the insects are exposed to the composition provided by the dispensing device for 60 minutes as recommended by the World Health Organization's pesticide evaluation guidelines.

[0056] The term "biological efficacy" as used herein refers to the efficacy of an insect control composition or insect control product in knocking down or killing a defined type of insect.

[0057] According to the above objects, the present invention provides a novel and effective liquid insecticide composition comprising the active ingredient "mefenthrin". In another embodiment, the present invention provides a cost-effective and simple method for preparing a composition comprising "mefenthrin".

[0058] Cyfluthrin is an isomeric composition of 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate [CAS.RN-352271-52-4], wherein the total trans isomer content ranges from 90% to 99.90% and the total cis isomer content ranges from 0.1% to 10%. The chemical structure of Cyfluthrin is shown below:

[0059]

[0060] Cypermethrin is a pyrethroid insecticide used to control mosquitoes and other insects in homes and public health areas.

[0061] In one embodiment of the present invention, the insecticidal composition of the present invention is a ready-to-use liquid formulation product, which contains a relatively low concentration of cyfluthrin, prepared from the active ingredient or technical grade or its MUP formulation.

[0062] In another embodiment of the present invention, the pesticidal composition of the present invention comprises 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, wherein the total trans isomers (1R, 3S and 1S, 3R are present in almost equal amounts) range from 90% to 99.90%, and the total cis isomers (1R, 3R and 1S, 3S are present in almost equal amounts) range from 0.1% to 10%.

[0063] In yet another embodiment of the present invention, the insecticidal composition of the present invention is an insecticidal liquid vaporizer composition comprising "mefluthrin" or its diluted form, including MUP formulations.

[0064] In another embodiment of the present invention, the mefenamic acid is diluted in a solvent or a mixture of solvents.

[0065] In yet another embodiment of the present invention, the pesticidal composition of the present invention comprises mefenamic acid in an amount of 0.01% to 5% w / w.

[0066] In another embodiment of the present invention, the insecticidal composition of the present invention controls household mosquitoes, flies and other insects in the field of public health, including but not limited to Aedes, Culex, Anopheles, Ephemeroptera, and many other species of flies, such as Aedes (Phlebotomus), sand flies, house flies (Silky Brown Wood Ants, etc.), stable flies, face flies, etc.

[0067] In yet another embodiment of the present invention, the insecticidal composition of the present invention controls insects in indoor spaces.

[0068] In another embodiment of the present invention, the pesticidal composition of the present invention comprises one or more chemically acceptable excipients selected from, but not limited to, antioxidants, fragrances, defoamers, emulsifiers, surfactants, wetting agents, antimicrobial / antibacterial agents, adjuvants, fillers, coloring pigments or dyes, preservatives, buffers and solvents thereof.

[0069] According to yet another embodiment of the present invention, the antioxidant is selected from butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) and tert-butylhydroquinone (tBHQ).

[0070] According to another embodiment of the present invention, the content of the antioxidant is 0.5-2% by weight of the total composition.

[0071] According to another embodiment of the present invention, the solvent is selected from one or more of glycol ether solvents, solvent oil (Ketrul D-80), deodorized kerosene, special fluid refined white oil (Hydroseal G3H), toluene, DMF and the like.

[0072] According to another embodiment of the present invention, the glycol ether solvent is selected from but not limited to tripropylene glycol monomethyl ether, ethylene glycol dimethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, ethylene glycol monohexyl ether, diethylene glycol dimethyl ether, butyl carbitol and the like.

[0073] According to yet another embodiment, the solvent is present in an amount of 90-99.5% by weight of the total composition.

[0074] According to another embodiment of the present invention, fragrance is optionally present in an amount of 0-2% by weight of the total composition.

[0075] According to one embodiment, there is disclosed a method of controlling / repelling mosquitoes, flies and other insects in domestic and public sanitary areas, the method comprising treating the area with a liquid insecticidal composition according to the present invention.

[0076] According to another embodiment of the present invention, there is provided a replaceable refill of a liquid insecticide composition according to the present invention, which is used together with an electrically heated dispensing device; wherein the refill comprises:

[0077] forming a body of a reservoir for a liquid composition;

[0078] A core, one end of which protrudes from the body and the other end is in contact with the liquid composition, wherein in use, the core transports the liquid insecticidal composition from the reservoir out of the body; and wherein the liquid composition comprises cyfluthrin in an amount of 0.01% to 5% by weight of the total composition; and one or more chemically acceptable excipients.

[0079] In yet another embodiment of the present invention, a method of making a liquid evaporator composition is disclosed, comprising:

[0080] General procedure for preparing cyfluthrin MUP

[0081] Cyfluthrin in a concentration range of 2% to 18% w / w is diluted in one or more glycol ethers, followed by a defined amount of toluene solvent to make the final MUP composition 100% w / w. In this 100% w / w MUP formulation, toluene is zero or no more than 10% w / w, and the remainder is one or more glycol ethers. Preferably, the glycol ether is selected from, but not limited to, tripropylene glycol monomethyl ether, ethylene glycol dimethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, ethylene glycol monohexyl ether, diethylene glycol dimethyl ether, butyl carbitol, and the like.

[0082] Preparation of 100 g of 5% Mefenthrin MUP

[0083] 40-90% w / w (i.e. 40-90 g) of solvent (a mixture of one or more than one glycol ether) is placed in a container and the liquid is stirred. 5% w / w of cyfluthrin active ingredient (adjusted to 100% purity) is gradually added to the mixture, i.e., for example, if the purity of cyfluthrin active ingredient is 95%, 5.26 g w / w of cyfluthrin is used. The mixture is stirred until a clear liquid solution is formed. Then 3 g of toluene solvent is added. An additional amount of glycol ether solvent is added to the solution to make it 100 grams w / w and stirring is further continued for up to 30 minutes. Thus, a 5% cyfluthrin MUP formulation liquid containing 92% glycol ether and 3% toluene is obtained.

[0084] General Procedure for the Manufacture of Cyfluthrin RTU Liquid Vaporizer (LV) Formulations

[0085] Production process flow chart

[0086]

[0087] Production process flow chart

[0088]

[0089] The present invention is illustrated by the following examples, but is not limited thereto.

[0090] Example

[0091] A stable liquid vaporizer (LV) formulation of cyfluthrin with 5% MUP

[0092] Weight of 100g of Cypermethrin LV

[0093]

[0094]

[0095] Example 1

[0096] 5% MUP for the preparation of a stable liquid vaporizer (LV) formulation of 0.7% cyfluthrin 100g weight of 0.7% cyfluthrin

[0097] Serial number raw material Weight (g) 1 5% Cypermethrin MUP 14 2 spices 1.0 3 Butylated Hydroxytoluene (BHT) 1.0 4 Ketrul D-80 42.0 5 Hydroseal G3-H Moderate

[0098] Example 2

[0099] 5% MUP for the preparation of a stable liquid vaporizer (LV) formulation of 0.5% cyfluthrin

[0100] Serial number raw material Weight (g) 1 5% Cypermethrin MUP 10 2 spices 1.0 3 Butylated Hydroxytoluene (BHT) 1.0 4 Deodorized kerosene Moderate

[0101] Example 3

[0102] 5% MUP for the preparation of a stable liquid vaporizer (LV) formulation of 0.9% cyfluthrin

[0103] Serial number raw material Weight (g) 1 5% Cypermethrin MUP 18 2 Butylated Hydroxytoluene (BHT) 1.0 3 Ethylene glycol dimethyl ether Moderate

[0104] Example 4

[0105] 5% MUP for the preparation of a stable liquid vaporizer (LV) formulation of 1.5% cyfluthrin

[0106] Serial number raw material Weight (g) 1 5% Cypermethrin MUP 30 2 spices 1.0 3 Butylated Hydroxytoluene (BHT) 1.0 4 Deodorized kerosene Moderate

[0107] Example 5

[0108] Cypermethrin Industrial Reagents Stable Liquid Evaporator (LV) Formula for Preparation of 1.5% Cypermethrin

[0109] Serial number raw material Weight (g) 1 93% Cypermethrin Industrial Reagent 1.61 to 1.62 2 spices 1.0 3 Butylated Hydroxytoluene (BHT) 1.0 4 Deodorized kerosene Moderate

[0110] Toxicity characteristics of cyfluthrin

[0111] In insecticide / pesticide compounds, toxicity and efficacy play crucial roles. New insecticide compounds are based on their effects on target pests and their toxicological profiles. For indoor use, inhalation toxicity is very important.

[0112] Acute inhalation toxicity:

[0113] Inhalation toxicity is very important in mosquito and flying insect repellent products. Most flying insect repellent products are based on evaporation and vaporization of the active ingredient. Household insecticide product forms such as coils, mats, aerosol sprays, liquid vaporizers, and other forms of burning and evaporating preparations are based on evaporation of the active ingredient. The concentration of the insecticide in the air and its evaporation are the most important aspects of flying insect repellent products.

[0114] Inhalation toxicity is measured by the "lethal concentration" LC50 value. LC50 (lethal concentration) is expressed as the weight of the test substance per standard volume of air (i.e. mg / L). The higher the mg / L value of LC50, the lower the inhalation toxicity and the safer the product.

[0115] Known pesticide compounds have the following reported LC50 values:

[0116] The LC50 of the insecticide "Promethrin" is 0.658 mg / L (the unit of measurement reported in the literature is 658 mg / m 3 , mg / L is 0.658);

[0117] The LC50 of the insecticide "transfluthrin" is 0.513 mg / L (the unit of measurement reported in the literature is 513 mg / m 3 , mg / L is 0.513);

[0118] The insecticide "Metofluthrin" was reported to have an LC50 of >1.08 and <1.96 mg / L.

[0119] These results have been published and reported for the respective pesticides.

[0120] Acute inhalation toxicity studies of cyfluthrin were conducted in rats according to OECD Guideline No. 403. In the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), for dusts and mists (mg / l), the insecticide "cyfluthrin" of the present invention belongs to Category 4 with a content of >1.0 and <5 mg / L.

[0121] This suggests that of all the compounds commonly used as active ingredients in household insecticide products, cyfluthrin has the lowest inhalation toxicity.

[0122] Biological efficacy and activity of insecticidal liquid vaporizer compositions containing cyfluthrin

[0123] The biological efficacy of the cyfluthrin liquid insecticidal composition against identified target pests has been compared with the biological efficacy of the commercially available liquid vaporizer composition containing 0.88% and 1.6% of transfluthrin against the free-flying mosquito species "Aedes aegypti". The mosquito species "Aedes aegypti" is the main vector of dengue, chikungunya and yellow fever viruses and other viral diseases. The effectiveness and efficacy of the insecticidal liquid composition was tested against 0.5%, 0.7% and 0.9% w / w cyfluthrin samples. A comparative study was also conducted to evaluate the biological efficacy of cyfluthrin with transfluthrin. Transfluthrin is a fast-acting pyrethroid insecticide and the most widely used mosquito repellent. 0.88% and 1.60% of transfluthrin liquid vaporizer compositions are available in the market.

[0124] The effectiveness / efficacy of mosquito repellent formulations is usually measured as "knockdown time" (KT) in minutes, expressed as a percentage of the mosquito test population, i.e. KT50 and KT90 values, which refer to the knockdown time for 50% and 90% of the test insect population, respectively. The shorter the time required for the KT value, the more effective the insecticide. Results may vary depending on study conditions, mosquito species and protocol.

[0125] Trial Details

[0126] The objective of this study was to evaluate the bioefficacy of liquid vaporizer (LV) samples (of varying concentrations of cyfluthrin) compared to 0.88% and 1.6% transfluthrin against Aedes aegypti in a Pitt-Grady chamber. The LV was preheated for approximately 24 hours to achieve core saturation. Prior to the start of the experiment, the initial weight of the LV was recorded and the test was started in a cold start (no preheat). The LV with heater was placed in the center of the chamber and turned on. The number of knocked-down insects was counted and recorded every 2 to 20 minutes and every 5 to 60 minutes thereafter.

[0127] The order of efficacy of KT90 is as follows: 0.9% cyfluthrin LV>0.7% cyfluthrin LV>0.5% cyfluthrin LV>1.6% transfluthrin LV>0.88% transfluthrin LV.

[0128] The results are summarized in Table 1 below:

[0129]

[0130]

[0131] (The lower the number of minutes, the better the effect)

[0132] It is obvious from the table above that 0.9% cyfluthrin LV showed the best results with the lowest KT50 and KT90 values ​​compared to other samples, followed by 0.7% cyfluthrin LV. In addition, both 0.9% and 0.7% cyfluthrin LV showed better efficacy compared to 0.88% transfluthrin LV and 1.6% transfluthrin LV.

[0133] The low dose of 0.5% flumethrin LV also showed comparable results to 0.88% transfluthrin LV and 1.6% transfluthrin LV.

[0134] Thus, the inventors of the present invention have successfully demonstrated that the biological efficacy of cyfluthrin is improved relative to the existing LV formulation of transfluthrin widely used in the market. In addition, cyfluthrin shows enhanced mosquito control ability at a much lower active agent dosage, thereby reducing the risk of exposure to the large amounts of active agents present in such household insect repellent products.

[0135] As can be seen from the foregoing, various modifications and variations may be implemented without departing from the true spirit and scope of the novel concepts of the present invention. It should be understood that no limitation to the specific embodiments shown is intended or should be inferred. It should be understood that all such modifications and improvements are appropriately included within the scope of the present application.

Claims

1. A novel liquid insecticide composition, characterized in that: Comprising 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, wherein the total trans isomer content (1R, 3S and 1S, 3R are almost equal) ranges from 90% to 99.90% and the total cis isomer content (1R, 3R and 1S, 3S are almost equal) ranges from 0.1 to 10%, or cyfluthrin having the following structure as an active ingredient; and one or more chemically acceptable excipients.

2. The insecticidal composition according to claim 1, characterized in that The content of the active ingredient is 0.01% to 5% by weight of the total composition.

3. The insecticidal composition according to claim 1, characterized in that The novel liquid insecticidal composition is made from MUP containing cyfluthrin.

4. The insecticidal composition according to claim 1, characterized in that The novel liquid insecticide composition is made of cyfluthrin.

5. The insecticidal composition according to claim 1, characterized in that The chemically acceptable excipient is one or more selected from antioxidants, flavors, defoamers, wetting agents, antimicrobial / antibacterial agents, adjuvants, fillers, coloring pigments or dyes, preservatives, buffers and solvents thereof.

6. The insecticidal composition according to claim 1 or 5, characterized in that: The antioxidant stabilizer is selected from butyl hydroxytoluene (BHT), butyl hydroxyanisole (BHA) and tert-butylhydroquinone (tBHQ), and its content is 0.5-2% by weight of the total composition.

7. The insecticidal composition according to claim 1 or 5, characterized in that: The solvent is selected from one or more glycol ether solvents, toluene, Ketrul D-80, deodorized kerosene and Hydrosal G-3H, and its content is 90-99.5% by weight of the total composition.

8. The insecticidal composition according to claim 7, characterized in that The one or more glycol ether solvents are selected from tripropylene glycol monomethyl ether, ethylene glycol dimethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, ethylene glycol monohexyl ether, diethylene glycol dimethyl ether, and butyl carbitol.

9. The insecticidal composition according to claim 1 or claim 5, characterized in that: Wherein the fragrance is optionally present in an amount of 0-2% by weight of the total composition.

10. A method for preparing a liquid insecticide composition, characterized in that: The following steps are involved: a. 0.01-5% of 5% cypermethrin MUP or cypermethrin industrial agent, mixed with 0.5-2% of an antioxidant and 90-99.5% by weight of one or more solvents, and optionally mixed with 0-2% by weight of spices; b. stirring the mixture of step a) to obtain a clear homogeneous liquid; c. filtering the homogenous liquid obtained in step b) to obtain a cyfluthrin liquid evaporator composition.

11. The insecticidal composition according to claim 1, characterized in that: The compositions described herein can be used to kill, knock down and / or repel mosquitoes and insects.

12. The insecticidal composition according to claim 1, characterized in that It is a composition that is emitted by a heat source, a liquid vaporizer composition, an electric liquid vaporizer composition, or an insect repellent liquid vaporizer composition having a wick.

13. The replaceable refill of the liquid insecticide composition according to claim 1, characterized in that: It is used together with an electric heating and emitting device; wherein the filling includes: a) forming a body of a reservoir for a liquid composition; b) a wick having one end protruding from the body and the other end in contact with the liquid composition, wherein, in use, the wick transports the liquid insecticidal composition from the reservoir out of the body.

14. A method of controlling / repelling mosquitoes and other insects from an area, characterized in that: The method comprises treating the area with the liquid insecticidal composition of claim 1.

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