A method and device for solidifying glucose oxidase
By designing a special membrane capsule processing and packaging mechanism in the glucose oxidase curing equipment, the problem of easy enzyme leakage is successfully solved, and the stability and packaging efficiency of the enzyme are improved.
Patent Information
- Application Number
- CN202411774988.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-05
- Publication Date
- 2025-04-08
AI Technical Summary
During the packaging process of existing glucose oxidase curing equipment, glucose oxidase is prone to leak from the membrane capsule, resulting in poor stability and difficult recovery.
By designing a special membrane capsule processing mechanism and wrapping mechanism in the curing equipment, using components such as agitation chamber, processing tube and expansion tube, glucose oxidase is encapsulated in the membrane capsule, and the capsule is formed by extrusion and segmentation to ensure the stable packaging of the enzyme.
It effectively solves the problems of glucose oxidase being easily deactivated, has poor stability and is difficult to recover during application, and improves the stability and packaging efficiency of the enzyme.
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Figure CN119776335A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of glucose oxidase solidification, in particular to a glucose oxidase solidification method and equipment. Background Art
[0002] Glucose oxidase immobilization equipment is a device specifically used to immobilize glucose oxidase. Glucose oxidase is an aerobic dehydrogenase that can specifically oxidize β-D-glucose into gluconic acid and hydrogen peroxide. In the feed industry, it has multiple functions such as protecting animal intestines, promoting digestion and absorption, and improving the body's immunity. However, free glucose oxidase has the disadvantages of easy inactivation, poor stability, and difficulty in recovery during application, so it is necessary to immobilize it.
[0003] After searching, the patent document with publication number CN116855375A discloses a solidification device for glucose oxidase, which includes a supporting component, a driving component, a mixing component, a clipping component and a gas transmission component. The mixing component includes a first feeding structure, a transmission structure, a discharging structure and a second feeding structure, and the transmission structure includes a first screw. The material for making the membrane capsule is added to the first feeding structure, and the glucose oxidase is added to the second feeding structure. The first screw is used to bring them close to each other to complete the encapsulation. The first threaded portion of the first screw has the same diameter as the second threaded portion, and the pitch of the first threaded portion is smaller than the pitch of the second threaded portion. The material for making the membrane capsule is first extruded and mixed by the first threaded portion, and then transmitted by the second threaded portion to improve the stability of the membrane capsule.
[0004] When the present invention is in use, the diameter of the fourth threaded portion is made smaller than the diameter of the second threaded portion, and the glucose oxidase is extruded and transmitted by the fourth threaded portion, and finally encapsulated, so that the glucose oxidase encapsulated inside the membrane capsule has better stability. However, this method is not convenient for the glucose oxidase to be completely wrapped by the membrane capsule, and there is a risk of glucose oxidase leaking from the membrane capsule.
[0005] Therefore, in view of the above problems, a method and equipment for solidifying glucose oxidase are proposed. Summary of the invention
[0006] In order to make up for the shortcomings of the prior art and solve the problem that glucose oxidase is easy to leak from the membrane capsule, the present invention provides a method and equipment for solidifying glucose oxidase.
[0007] A method for solidifying glucose oxidase, the method comprising the following steps:
[0008] S1: Create a solidification task for glucose oxidase;
[0009] S2: Encapsulating glucose oxidase in membrane vesicles, and squeezing and dividing them to form capsules;
[0010] S3: Detect the finished products after curing, and if they are qualified, collect them;
[0011] S4: Inspect the finished product after curing. If it is a defective product, further process it;
[0012] The curing equipment includes:
[0013] Base plate;
[0014] A membrane capsule handling mechanism fixedly mounted on the top of the base plate;
[0015] A wrapping mechanism fixedly mounted on the top of the base plate;
[0016] A detection mechanism fixedly mounted on one side of the wrapping mechanism;
[0017] A screening mechanism fixedly mounted on the top of the base plate;
[0018] The membrane capsule processing mechanism includes a stirring chamber, a first discharge pipe is fixedly connected to the bottom of the stirring chamber, a processing pipe is movably connected to one end of the first discharge pipe, a first support frame is fixedly connected to the top of the base plate, a second support frame is fixedly connected to the top of the first support frame, a storage box is fixedly connected to the top of the second support frame, an expansion tube is fixedly connected to one side of the first support frame, a push rod is slidably installed on the other side of the first support frame, a detector is fixedly connected to one side of the second support frame, and a conveyor belt is rotatably installed on the top of the base plate.
[0019] A solidification device for glucose oxidase, wherein four support legs are fixedly installed on the top of the base plate, and the four support legs are fixedly installed together on the bottom of a stirring chamber. A first feed inlet is opened on the top of the stirring chamber, and a first motor is fixedly installed on the top of the stirring chamber. The output shaft of the first motor passes through the inner cavity of the stirring chamber and is fixedly connected to a rotating shaft, and a plurality of stirring rods and stirring plates are fixedly connected to the outer surface of the rotating shaft.
[0020] Preferably, a first air pump is fixedly connected to the top of the stirring chamber, a second air pipe is fixedly connected to one side of the first air pump, a second electric valve is fixedly installed on the outer surface of the second air pipe, the first air pipe is fixedly connected to the outer surface of the second air pipe, a first electric valve is fixedly installed on the outer surface of the first air pipe, the first air pipe is located between the second electric valve and the first air pump, one end of the second air pipe is connected to the inner cavity of the first discharge pipe, and a valve is fixedly installed on the outer surface of the first discharge pipe.
[0021] Preferably, the wrapping mechanism includes a first air inlet head, which is fixedly installed on the top of the processing tube, a baffle is fixedly connected to the bottom of the processing tube, a connecting block is fixedly installed on the top of the first support frame, a second groove is opened on the top of the connecting block, a second limiting groove is opened on the bottom wall of the second groove, first limiting grooves are opened on both sides of the connecting block, the processing tube is slidably installed on the inner surface of the first limiting groove, a first groove is opened on one side of the first support frame, and the push rod is slidably installed on the inner surface of the first groove.
[0022] Preferably, two first electric telescopic rods are fixedly installed on the bottom of the second support frame, and the two first electric telescopic rods are jointly fixedly installed on the top of the processing tube, a second air pump is fixedly installed on the top of the storage box, one end of the second air pump passes through the inner cavity of the storage box, a second feed port is opened on the top of the storage box, a second discharge pipe is fixedly connected to one side of the storage box, a third discharge pipe is fixedly connected to one end of the second discharge pipe, a second electric telescopic rod is fixedly connected to the outer surface of the third discharge pipe, and the second electric telescopic rod is fixedly installed on the top of the connecting block.
[0023] Preferably, a threaded groove is provided on one side of the push rod, a threaded rod is threadedly connected to the inner surface of the threaded groove, one end of the threaded rod is fixedly connected to the second motor, one side of the second motor is fixedly connected to a fixing plate, the fixing plate is fixedly installed on the outer surface of the first feeding pipe, two third grooves are provided on the outer surface of the push rod, a limiting rod is slidably installed on the inner surface of the third groove, and both ends of the limiting rod are respectively fixedly installed between the fixing plate and the first support frame.
[0024] Preferably, the detection mechanism includes a connecting rod, the connecting rod is fixedly mounted on one side of the second support frame, the detector is fixedly mounted on one end of the connecting rod, the top of the expansion tube is fixedly connected to the second air inlet head, one side of the expansion tube is provided with two fourth grooves, a rotating block is rotatably mounted on the inner surface of the fourth groove, one end of the rotating block is rotatably connected to a sealing plate, a fifth groove is provided on one side of the sealing plate, the rotating block is rotatably mounted on the inner surface of the rotating block, a sixth groove is provided at the bottom of the sealing plate, a rotating rod is rotatably mounted on the inner surface of the sixth groove, the bottom of the rotating rod is fixedly connected to a connecting shaft, a cross plate is fixedly mounted on one side of the first support frame, three pulleys are rotatably mounted on the top of the cross plate, two adjacent pulleys are fixedly connected to gears at the bottom, the two gears are meshed with each other, one of the pulleys with the gear is driven by a belt with the other pulley, a third motor is fixedly mounted on the bottom of the cross plate, and an output shaft of the third motor passes through the cross plate and is fixedly mounted on the bottom of the pulley.
[0025] Preferably, the screening mechanism includes two support plates, both of which are fixedly mounted on the top of the base plate, two conveying rollers are rotatably mounted on opposite surfaces of the two support plates, the conveyor belt is wound around and mounted on the outer surfaces of the two conveying rollers, a fourth motor is fixedly mounted on one side of the support plate, and the output shaft of the fourth motor passes through the support plate and is fixedly mounted on one side of the conveying roller.
[0026] The present invention is beneficial in that:
[0027] 1. The present invention places the membrane capsule material into the stirring chamber through the first feed port, and the first motor output shaft rotates with the rotating shaft, and the rotating shaft drives the stirring rod and the stirring plate to rotate, so as to stir the material used to manufacture the membrane capsule. After the stirring is completed, air is supplied to the stirring chamber through the first air pump to increase the air pressure in the stirring chamber, and then the opening and closing of the first electric valve, the second electric valve and the valve are coordinated to discharge all the membrane capsules in the stirring chamber.
[0028] 2. The present invention moves the processing tube and the baffle plate upward by the first electric telescopic rod, and the baffle plate cuts off the membrane capsule in the first feeding tube. The position of the third feeding tube is changed by the extension and shortening of the second electric telescopic rod, so that the end of the third feeding tube is inserted into the middle of the processing tube. Then, the second air pump increases the pressure in the storage box cavity to output the glucose oxidase in the storage box to the membrane capsule in the processing tube. As the volume of the membrane capsule increases, the membrane capsule will diffuse into the expansion tube. After the output is completed, the threaded rod is rotated in the threaded groove by the output shaft of the second motor, and the limiting push rod cooperates with the third groove and the limit rod to slide along the first groove to push the membrane capsule out. By encapsulating the glucose oxidase in the membrane capsule and squeezing and dividing it to form a capsule, the problems of easy inactivation, poor stability and difficulty in recovery of free glucose oxidase during application are solved.
[0029] 3. The present invention uses the output shaft of the third motor to drive through the belt and meshing of two gears, so that the three pulleys start to rotate, and two of the pulleys rotate with the rotating rod on the inner surface of the sixth groove, thereby opening the two sealing plates. At this time, the membrane capsule can be discharged through the expansion tube, and the discharged membrane capsule falls to the top of the conveyor belt. After being detected by the detector, the fourth motor rotates in different directions, thereby driving the conveyor belt to rotate in different directions, bringing qualified or unqualified products to different directions. BRIEF DESCRIPTION OF THE DRAWINGS
[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.
[0031] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present invention;
[0032] Figure 2 This is a schematic diagram of the top structure of a stirring chamber according to an embodiment of the present invention;
[0033] Figure 3 A schematic diagram of the internal structure of a stirring chamber according to an embodiment of the present invention;
[0034] Figure 4 A schematic diagram of the wrapping mechanism structure of an embodiment of the present invention;
[0035] Figure 5 A schematic cross-sectional structure diagram of a wrapping mechanism according to an embodiment of the present invention;
[0036] Figure 6 A schematic diagram of the screening mechanism structure of an embodiment of the present invention;
[0037] Figure 7 A schematic diagram of a third motor driving structure according to an embodiment of the present invention;
[0038] Figure 8 The present invention is a flowchart of an embodiment of the present invention.
[0039] In the figure: 1, bottom plate; 2, supporting leg; 21, stirring chamber; 211, first feed port; 3, first air pump; 31, first air pipe; 311, first electric valve; 32, second air pipe; 321, second electric valve; 33, first feed pipe; 331, valve; 4, first motor; 41, rotating shaft; 42, stirring rod; 43, stirring plate; 5, first support frame; 51, processing pipe; 511, first air inlet head; 501, first groove; 52, baffle; 53, connecting block; 531, second groove; 532, first limit groove; 533, second limit groove; 54, second support frame; 541, first electric telescopic rod; 55, storage box; 551, second feed port; 5 52. Second air pump; 553. Second feeding pipe; 554. Second electric telescopic rod; 555. Third feeding pipe; 56. Push rod; 561. Third groove; 562. Fixed plate; 563. Limit rod; 564. Threaded rod; 565. Second motor; 6. Expansion tube; 601. Fourth groove; 602. Rotating block; 603. Second air inlet head; 61. Sealing plate; 611. Fifth groove; 612. Sixth groove; 62. Rotating rod; 63. Connecting shaft; 64. Pulley; 65. Gear; 66. Belt; 67. Third motor; 68. Cross plate; 7. Connecting rod; 71. Detector; 8. Support plate; 81. Conveyor roller; 82. Conveyor belt; 83. Fourth motor. DETAILED DESCRIPTION
[0040] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0041] See also Figures 1 to 7 As shown, a method for solidifying glucose oxidase comprises the following steps:
[0042] S1: Create a solidification task for glucose oxidase;
[0043] S2: Encapsulating glucose oxidase in membrane capsules through a solidification device, and extruding and dividing to form capsules;
[0044] S3: Detect the finished products after curing, and if they are qualified, collect them;
[0045] S4: Inspect the finished product after curing. If it is a defective product, further process it;
[0046] The curing equipment includes: a base plate 1; a membrane capsule processing mechanism fixedly installed on the top of the base plate 1; a wrapping mechanism fixedly installed on the top of the base plate 1; a detection mechanism fixedly installed on one side of the wrapping mechanism; a screening mechanism fixedly installed on the top of the base plate 1; the membrane capsule processing mechanism includes a stirring chamber 21, a first discharge pipe 33 is fixedly connected to the bottom of the stirring chamber 21, a processing pipe 51 is movably connected to one end of the first discharge pipe 33, a first support frame 5 is fixedly connected to the top of the base plate 1, a second support frame 54 is fixedly connected to the top of the first support frame 5, a storage box 55 is fixedly connected to the top of the second support frame 54, an expansion tube 6 is fixedly connected to one side of the first support frame 5, a push rod 56 is slidably installed on the other side of the first support frame 5, a detector 71 is fixedly connected to one side of the second support frame 54, and a conveyor belt 82 is rotatably installed on the top of the base plate 1.
[0047] Encapsulating glucose oxidase with membrane capsules helps solve the problems of easy inactivation, poor stability and difficulty in recycling of free glucose oxidase during application.
[0048] When the present invention is used, the membrane capsule processing mechanism can stir the membrane capsule used to encapsulate glucose oxidase, the membrane capsule is wrapped with glucose oxidase by the wrapping mechanism, the product leaking glucose oxidase from the membrane capsule and the finished product without leakage can be distinguished by the screening mechanism, and the finished product can be separated from the unqualified product by controlling the membrane capsule to move in different directions;
[0049] The membrane capsule in the stirring chamber 21 flows out to the processing tube 51 through the first discharge pipe 33, and then the processing tube 51 moves upward, and then the storage box 55 contacts the processing tube 51. At this time, the glucose oxidase in the storage box 55 can be transported to the membrane capsule located in the inner cavity of the processing tube 51. As the glucose oxidase is input into the membrane capsule, the volume of the membrane capsule will also increase, and the enlarged part will enter the expansion tube 6. After the wrapping work is completed, the push rod 56 pushes the membrane capsule out of the processing tube 51 and the expansion tube 6 and drops it to the top of the conveyor belt 82. At this time, the detector 71 will The membrane capsules are inspected to detect whether there is any glucose oxidase leakage from the membrane capsules. The finished products and semi-finished products will be carried in different directions by the conveyor belt 82. The staff will collect the finished products. For unqualified products, the reasons for their substandard quality are first analyzed. If the filling is uneven, the seal is not tight, and glucose oxidase has leaked, the glucose oxidase in the unqualified products will be taken out and added to the storage box 55 again. If it is detected that there is a problem with the membrane capsules or the glucose oxidase raw materials, the entire production line needs to be stopped and replaced with qualified membrane capsules or glucose oxidase raw materials.
[0050] like Figure 3 As shown, a solidification device for glucose oxidase is provided, wherein four supporting legs 2 are fixedly installed on the top of the base plate 1, and the four supporting legs 2 are fixedly installed together on the bottom of a stirring chamber 21, a first feed inlet 211 is provided on the top of the stirring chamber 21, a first motor 4 is fixedly installed on the top of the stirring chamber 21, an output shaft of the first motor 4 passes through the inner cavity of the stirring chamber 21 and is fixedly connected to a rotating shaft 41, and a plurality of stirring rods 42 and a stirring plate 43 are fixedly connected to the outer surface of the rotating shaft 41.
[0051] When the present invention is in use, the output shaft of the first motor 4 drives the rotating shaft 41 to rotate, and the rotating shaft 41 drives the stirring rod 42 and the stirring plate 43 to rotate. As the stirring rod 42 and the stirring plate 43 rotate, the materials used to manufacture the membrane capsules in the stirring chamber 21 are evenly stirred, and the materials used to manufacture the membrane capsules enter the stirring chamber 21 through the first feed port 211.
[0052] Further, such as Figure 2 As shown, the top of the stirring chamber 21 is fixedly connected to the first air pump 3, one side of the first air pump 3 is fixedly connected to the second air pipe 32, the outer surface of the second air pipe 32 is fixedly installed with a second electric valve 321, the outer surface of the second air pipe 32 is fixedly connected to the first air pipe 31, the outer surface of the first air pipe 31 is fixedly installed with a first electric valve 311, the first air pipe 31 is located between the second electric valve 321 and the first air pump 3, one end of the second air pipe 32 is connected to the inner cavity of the first discharge pipe 33, and the outer surface of the first discharge pipe 33 is fixedly installed with a valve 331.
[0053] When the present invention is in use, the air pressure in the inner cavity of the stirring chamber 21 is increased by the first air pump 3. When the membrane capsules in the stirring chamber 21 need to be discharged, the second electric valve 321 is closed and the first electric valve 311 is opened. Air is supplied to the stirring chamber 21 through the first air pipe 31, so that the membrane capsules in the stirring chamber 21 can be discharged into the first discharge pipe 33. Eventually, some membrane capsules will remain in the first discharge pipe 33. At this time, the valve 331 and the first electric valve 311 are closed, and the second electric valve 321 is opened to supply air to the first discharge pipe 33, so that all the membrane capsules in the first discharge pipe 33 can be discharged.
[0054] Further, such as Figure 4 and Figure 5 As shown, the wrapping mechanism includes a first air inlet head 511, which is fixedly mounted on the top of the processing tube 51, a baffle 52 is fixedly connected to the bottom of the processing tube 51, a connecting block 53 is fixedly mounted on the top of the first support frame 5, a second groove 531 is opened on the top of the connecting block 53, a second limiting groove 533 is opened on the bottom wall of the second groove 531, first limiting grooves 532 are opened on both sides of the connecting block 53, the processing tube 51 is slidably mounted on the inner surface of the first limiting groove 532, a first groove 501 is opened on one side of the first support frame 5, and the push rod 56 is slidably mounted on the inner surface of the first groove 501;
[0055] Two first electric telescopic rods 541 are fixedly installed at the bottom of the second support frame 54, and the two first electric telescopic rods 541 are fixedly installed on the top of the processing tube 51. A second air pump 552 is fixedly installed on the top of the storage box 55, and one end of the second air pump 552 passes through the inner cavity of the storage box 55. A second feed inlet 551 is opened on the top of the storage box 55. A second discharge pipe 553 is fixedly connected to one side of the storage box 55, and a third discharge pipe 555 is fixedly connected to one end of the second discharge pipe 553. The outer surface of the third discharge pipe 555 is fixedly connected to a second electric telescopic rod 554, and the second electric telescopic rod 554 is fixedly installed on the top of the connecting block 53.
[0056] A threaded groove is provided on one side of the push rod 56, and a threaded rod 564 is threadedly connected to the inner surface of the threaded groove. A second motor 565 is fixedly connected to one end of the threaded rod 564, and a fixing plate 562 is fixedly connected to one side of the second motor 565. The fixing plate 562 is fixedly installed on the outer surface of the first feeding tube 33. Two third grooves 561 are provided on the outer surface of the push rod 56, and a limiting rod 563 is slidably installed on the inner surface of the third groove 561. Both ends of the limiting rod 563 are respectively fixedly installed between the fixing plate 562 and the first support frame 5.
[0057] When the present invention is in use, the position of the processing tube 51 can be changed by the two first electric telescopic rods 541. As the processing tube 51 rises, the baffle 52 blocks one end of the first feed tube 33, so that the processing tube 51 moves to the third feed tube 555 and is inserted into the inner cavity of the processing tube 51 and is located in the middle of the membrane capsule in the inner cavity of the processing tube 51. The storage box 55 is pressurized by the second air pump 552 to extrude the glucose oxidase into the third feed tube 555 through the second feed tube 553. The position of the third feed tube 555 can be further controlled by extending and shortening the second electric telescopic rod 554, so that the end of the third feed tube 555 is located in the center of the membrane capsule in the processing tube 51. The second feed tube 553 can fix the sliding position of the processing tube 51, and the first limit groove 532 can limit the sliding trajectory of the processing tube 51.
[0058] When glucose oxidase is output to the membrane capsule in the processing tube 51, the volume of the membrane capsule will increase. At this time, the enlarged membrane capsule will diffuse into the expansion tube 6. After the input is completed, the threaded rod 564 is rotated by the output shaft of the second motor 565. The threaded rod 564 rotates on the inner surface of the threaded groove. The push rod 56 is restricted by the cooperation of the third groove 561 and the limit rod 563 to slide along the first groove 501, thereby discharging the membrane capsule wrapped with glucose oxidase through the expansion tube 6.
[0059] Further, such as Figure 7 As shown, the detection mechanism includes a connecting rod 7, the connecting rod 7 is fixedly mounted on one side of the second support frame 54, the detector 71 is fixedly mounted on one end of the connecting rod 7, the top of the expansion tube 6 is fixedly connected to the second air inlet head 603, one side of the expansion tube 6 is provided with two fourth grooves 601, the inner surface of the fourth groove 601 is rotatably mounted with a rotating block 602, one end of the rotating block 602 is rotatably connected with a sealing plate 61, one side of the sealing plate 61 is provided with a fifth groove 611, the rotating block 602 is rotatably mounted on the inner surface of the rotating block 602, and the bottom of the sealing plate 61 is provided with a sixth groove 612, A rotating rod 62 is rotatably installed on the inner surface of the sixth groove 612, and a connecting shaft 63 is fixedly connected to the bottom of the rotating rod 62. A transverse plate 68 is fixedly installed on one side of the first support frame 5, and three pulleys 64 are rotatably installed on the top of the transverse plate 68, wherein two adjacent pulleys 64 are fixedly connected to gears 65 at the bottom, and the two gears 65 are meshed with each other, and one of the pulleys 64 with the gear 65 is transmitted to the other pulley 64 via a belt 66, and a third motor 67 is fixedly installed at the bottom of the transverse plate 68, and the output shaft of the third motor 67 passes through the transverse plate 68 and is fixedly installed at the bottom of the pulley 64.
[0060] When the present invention is in use, the output shaft of the third motor 67 drives the pulley 64 and the gear 65 to rotate, the two gears 65 are meshed with each other, and the three pulleys 64 start to rotate through the belt 66. The rotation directions of the two pulleys 64 connected with the connecting shaft 63 are different. At this time, the two rotating rods 62 rotate on the inner surfaces of the two sixth grooves 612 respectively, and the two sealing plates 61 are driven. At this time, the rotating block 602 rotates on the inner surfaces of the fourth groove 601 and the fifth groove 611, and the membrane bag can be discharged through the expansion tube 6.
[0061] Further, such as Figure 6 As shown, the screening mechanism includes two support plates 8, and the two support plates 8 are fixedly mounted on the top of the base plate 1. Two conveying rollers 81 are rotatably mounted on opposite surfaces of the two support plates 8. The conveyor belt 82 is wound around the outer surfaces of the two conveying rollers 81. A fourth motor 83 is fixedly mounted on one side of the support plate 8, and the output shaft of the fourth motor 83 passes through the support plate 8 and is fixedly mounted on one side of the conveying roller 81.
[0062] When the present invention is in use, the membrane capsules discharged through the expansion tube 6 will fall onto the conveyor belt 82. At this time, the detector 71 scans and detects the membrane capsules, and the fourth motor 83 drives the two conveyor rollers 81 to rotate in different directions, so that the finished products and unqualified products can be brought to different positions respectively, which is convenient for the staff to distinguish and collect them.
[0063] Working principle: First, the material for making membrane capsules is put into the stirring chamber 21 through the first feed port 211, and the output shaft of the first motor 4 drives the rotating shaft 41 to rotate, and the rotating shaft 41 drives the stirring rod 42 and the stirring plate 43 to rotate, so as to stir the material for making membrane capsules. After the stirring is completed, the first air pump 3 is used to supply air to the stirring chamber 21 to increase the air pressure in the stirring chamber 21, and then the opening and closing of the first electric valve 311, the second electric valve 321 and the valve 331 are coordinated to discharge all the membrane capsules in the stirring chamber 21. The discharged membrane capsules first enter the processing tube 51, and the processing tube 51 and the baffle 52 are also moved upward by the first electric telescopic rod 541. The baffle 52 cuts off the membrane capsule in the first feeding tube 33, and the second electric telescopic rod 554 is extended and shortened to change the position of the third feeding tube 555, so that the end of the third feeding tube 555 is inserted into the middle of the processing tube 51, and then the second air pump 552 pressurizes the inner cavity of the storage box 55 to output the glucose oxidase in the storage box 55 to the membrane capsule in the processing tube 51. As the volume of the membrane capsule increases, the membrane capsule will diffuse into the expansion tube 6. After the output is completed, the output shaft of the second motor 565 drives the threaded rod 564 to rotate in the threaded groove, and the limiting push rod 56 cooperates with the third groove 561 and the limiting rod 563 to slide along the first groove 501, thereby pushing out the membrane capsule;
[0064] Before the membrane capsule is pushed out, the output shaft of the third motor 67 is driven by the belt 66 and the two gears 65 are meshed, so that the three pulleys 64 all start to rotate, and two of the pulleys 64 drive the rotating rod 62 to rotate on the inner surface of the sixth groove 612, thereby opening the two sealing plates 61. At this time, the membrane capsule can be discharged through the expansion tube 6, and the ejected membrane capsule falls to the top of the conveyor belt 82. After being detected by the detector 71, the fourth motor 83 rotates in different directions, thereby driving the conveyor belt 82 to rotate in different directions, bringing qualified or unqualified products to different directions.
[0065] Since the structure of the detector 71 belongs to the prior art, it is not described in the present invention document.
[0066] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.
[0067] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, and these changes and improvements all fall within the scope of the present invention to be protected.
Claims
1. A method for immobilizing glucose oxidase, characterized in that: The method comprises the following steps: S1: Create a solidification task for glucose oxidase; S2: Encapsulating glucose oxidase in membrane capsules through a solidification device, and extruding and dividing to form capsules; S3: Detect the finished products after curing, and if they are qualified, collect them; S4: Inspect the finished product after curing. If it is a defective product, further process it; The curing equipment includes: Bottom plate (1); A membrane capsule processing mechanism fixedly mounted on the top of the base plate (1); A wrapping mechanism fixedly mounted on the top of the base plate (1); A detection mechanism fixedly mounted on one side of the wrapping mechanism; A screening mechanism fixedly mounted on the top of the base plate (1); The membrane capsule processing mechanism includes a stirring chamber (21), a first discharge pipe (33) is fixedly connected to the bottom of the stirring chamber (21), one end of the first discharge pipe (33) is movably connected to a processing tube (51), the top of the base plate (1) is fixedly connected to a first support frame (5), the top of the first support frame (5) is fixedly connected to a second support frame (54), the top of the second support frame (54) is fixedly connected to a storage box (55), one side of the first support frame (5) is fixedly connected to an expansion tube (6), the other side of the first support frame (5) is slidably mounted with a push rod (56), one side of the second support frame (54) is fixedly connected to a detector (71), and a conveyor belt (82) is rotatably mounted on the top of the base plate (1).
2. A glucose oxidase solidification device, which uses the glucose oxidase solidification method according to claim 1 to solidify glucose oxidase, characterized in that: Four support legs (2) are fixedly mounted on the top of the bottom plate (1), and the four support legs (2) are fixedly mounted together on the bottom of the stirring chamber (21). A first feed port (211) is provided on the top of the stirring chamber (21). A first motor (4) is fixedly mounted on the top of the stirring chamber (21), and an output shaft of the first motor (4) passes through the inner cavity of the stirring chamber (21) and is fixedly connected to a rotating shaft (41). A plurality of stirring rods (42) and stirring plates (43) are fixedly connected to the outer surface of the rotating shaft (41).
3. The solidification device of glucose oxidase according to claim 2, characterized in that: The top of the stirring chamber (21) is fixedly connected to a first air pump (3); one side of the first air pump (3) is fixedly connected to a second air pipe (32); a second electric valve (321) is fixedly installed on the outer surface of the second air pipe (32); the outer surface of the second air pipe (32) is fixedly connected to the first air pipe (31); a first electric valve (311) is fixedly installed on the outer surface of the first air pipe (31); the first air pipe (31) is located between the second electric valve (321) and the first air pump (3); one end of the second air pipe (32) is connected to the inner cavity of the first discharge pipe (33); and a valve (331) is fixedly installed on the outer surface of the first discharge pipe (33).
4. The solidification device of glucose oxidase according to claim 1, characterized in that: The wrapping mechanism comprises a first air inlet head (511), the first air inlet head (511) is fixedly mounted on the top of the processing tube (51), the bottom of the processing tube (51) is fixedly connected with a baffle (52), the top of the first support frame (5) is fixedly mounted with a connecting block (53), the top of the connecting block (53) is provided with a second groove (531), the bottom wall of the second groove (531) is provided with a second limiting groove (533), both sides of the connecting block (53) are provided with first limiting grooves (532), the processing tube (51) is slidably mounted on the inner surface of the first limiting groove (532), one side of the first support frame (5) is provided with a first groove (501), and the push rod (56) is slidably mounted on the inner surface of the first groove (501).
5. The solidification device of glucose oxidase according to claim 4, characterized in that: Two first electric telescopic rods (541) are fixedly installed at the bottom of the second support frame (54), and the two first electric telescopic rods (541) are fixedly installed on the top of the processing tube (51). A second air pump (552) is fixedly installed on the top of the storage box (55), and one end of the second air pump (552) passes through the inner cavity of the storage box (55). A second feed port (551) is opened on the top of the storage box (55), and a second discharge pipe (553) is fixedly connected to one side of the storage box (55), and a third discharge pipe (555) is fixedly connected to one end of the second discharge pipe (553), and a second electric telescopic rod (554) is fixedly connected to the outer surface of the third discharge pipe (555), and the second electric telescopic rod (554) is fixedly installed on the top of the connecting block (53).
6. The glucose oxidase solidification device according to claim 5, characterized in that: A threaded groove is provided on one side of the push rod (56), and a threaded rod (564) is threadedly connected to the inner surface of the threaded groove. One end of the threaded rod (564) is fixedly connected to a second motor (565), and one side of the second motor (565) is fixedly connected to a fixing plate (562). The fixing plate (562) is fixedly installed on the outer surface of the first feeding tube (33). Two third grooves (561) are provided on the outer surface of the push rod (56), and a limiting rod (563) is slidably installed on the inner surface of the third groove (561). The two ends of the limiting rod (563) are respectively fixedly installed between the fixing plate (562) and the first support frame (5).
7. The glucose oxidase solidification device according to claim 6, characterized in that: The detection mechanism comprises a connecting rod (7), wherein the connecting rod (7) is fixedly mounted on one side of the second support frame (54), the detector (71) is fixedly mounted on one end of the connecting rod (7), the top of the expansion tube (6) is fixedly connected to a second air inlet head (603), one side of the expansion tube (6) is provided with two fourth grooves (601), a rotating block (602) is rotatably mounted on the inner surface of the fourth groove (601), one end of the rotating block (602) is rotatably connected to a sealing plate (61), one side of the sealing plate (61) is provided with a fifth groove (611), the rotating block (602) is rotatably mounted on the inner surface of the rotating block (602), the bottom of the sealing plate (61) is provided with a sixth groove (612), and the A rotating rod (62) is rotatably mounted on the inner surface of the six grooves (612), and a connecting shaft (63) is fixedly connected to the bottom of the rotating rod (62). A transverse plate (68) is fixedly mounted on one side of the first support frame (5), and three pulleys (64) are rotatably mounted on the top of the transverse plate (68), wherein two adjacent pulleys (64) are fixedly connected to the bottom with gears (65), and the two gears (65) are meshed with each other, and one of the pulleys (64) with the gear (65) is driven by the other pulley (64) via a belt (66), and a third motor (67) is fixedly mounted on the bottom of the transverse plate (68), and the output shaft of the third motor (67) passes through the transverse plate (68) and is fixedly mounted on the bottom of the pulley (64).
8. The glucose oxidase solidification device according to claim 7, characterized in that: The screening mechanism comprises two support plates (8), the two support plates (8) are fixedly mounted on the top of the bottom plate (1), two conveying rollers (81) are rotatably mounted on opposite surfaces of the two support plates (8), the conveying belt (82) is wound around the outer surfaces of the two conveying rollers (81), a fourth motor (83) is fixedly mounted on one side of the support plate (8), and the output shaft of the fourth motor (83) passes through the support plate (8) and is fixedly mounted on one side of the conveying roller (81).
Citation Information
Patent Citations
Glucose oxidase curing equipment
CN116855375A