An integrated drug safety rapid testing device for drug safety testing

Abstract

The present invention discloses an integrated drug safety quick inspection device for drug safety inspection, and the present invention comprises: a mass spectrometer, a heat dissipation structure and a drug crushing component. The present invention crushes drugs through a crushing piece, screens drugs through a screening plate, and oversized drug particles enter a reflux lifting column through a reflux bucket, and the drug particles are re-put into a crushing box for secondary crushing, and so on, and qualified drug powder can be obtained without the need for staff to crush the drugs multiple times. The water tank drives the column to rise and fall through the action of a lifting rod, an L rod and a lifting column, and the second hinge seat drives the first hinge seat to move through the hinge plate. Under the guiding action of the first guide block, the first hinge seat drives the sliding block to move up and down along the screening plate, and drives the cleaning plate to move through the sliding block, and the cleaning plate cleans the drug particles remaining on the screening plate to avoid blocking the screening plate, and completes the self-cleaning work while completing the heat dissipation work, which is simple and convenient.

Description

Technical Field

[0001] The present invention relates to the technical field of drug safety detection, and in particular to an integrated drug safety rapid detection device for drug safety detection. Background Art

[0002] Drug safety testing is a critical task that involves ensuring that drugs meet safety, efficacy, and quality standards during production, distribution, and use. Mass spectrometry is used in conjunction with chromatography to analyze molecular weight, structure, and components in complex mixtures.

[0003] The Chinese invention patent with authorization announcement number CN117491574A discloses an integrated drug safety rapid inspection device for drug safety testing, including an integrated rapid inspection system body, a U-shaped bracket fixedly connected to the middle part of the lower part of the integrated rapid inspection system body, characterized in that a convenient drug placement plate structure is slidably provided at the inner bottom of the U-shaped bracket; the convenient drug placement plate structure includes a placement plate, and the placement plate is slidably provided at the inner bottom of the U-shaped bracket; limited grooves are sequentially provided on the upper and middle sides of the placement plate from left to right, and medicine boxes for placing medicines are respectively provided on the inner sides of the limited grooves, wherein the medicine boxes can be moved upward from the inside of the limited grooves. The medicine boxes in the present invention can be disassembled, so that when taking medicines, the operator can directly disassemble the medicine boxes and dump the medicine boxes. This way of taking medicines can quickly take out all the medicines, achieve the effect of rapid medicine taking, effectively improve the efficiency of taking medicines, and make it more convenient to use.

[0004] The Chinese utility model patent with authorization announcement number CN212459544U discloses an integrated drug safety rapid inspection system for drug safety detection, including a base, a gas chromatograph body is placed on the top of the base, sleeves are fixedly connected on both sides of the bottom of the inner cavity of the base, vertical rods are fixedly connected on both sides of the bottom of the inner cavity of the sleeve, the top of the vertical rod is fixedly connected to a limit block, a reset spring is sleeved on the surface of the vertical rod, a cross bar is penetrated on the surface of the vertical rod, connecting rods are fixedly connected on both sides of the top of the cross bar, and a moving rod is fixedly connected to the top of the connecting rod. The utility model has the advantage of easy installation through the coordinated use of sleeves, vertical rods, limit blocks, reset springs, cross bars, connecting rods, moving rods, first sliders, first slide grooves, clamping blocks and limit rods, and solves the problem that the installation process of existing gas chromatographs for drug safety detection is too complicated, which leads to inconvenience in installation.

[0005] The integrated drug safety rapid testing device in the above patent needs to crush the drugs when performing chemical or physical analysis on the drugs. In mass spectrometry analysis, the samples need to be converted into gas phase ions. Uniform fine powder samples help to achieve more effective ionization in the ion source and improve signal strength. The fineness of the samples cannot be guaranteed during the crushing process, and multiple crushings are required, which is time-consuming and labor-intensive. Summary of the invention

[0006] The purpose of the present invention is to provide an integrated drug safety rapid testing device for drug safety detection, which solves the problem that the integrated drug safety rapid testing device needs to crush the drugs when performing chemical or physical analysis on the drugs. In mass spectrometry analysis, the samples need to be converted into gas phase ions. Uniform fine powder samples help to achieve more effective ionization in the ion source and improve signal strength. The fineness of the samples cannot be guaranteed during the crushing process, and multiple crushings are required, which is time-consuming and labor-intensive.

[0007] The present invention solves the above technical problems through the following technical solutions, which include: A mass spectrometer, wherein a movable base is installed at the bottom of the mass spectrometer, and a universal wheel is installed at the bottom of the movable base; A heat dissipation structure, the heat dissipation structure being installed on the back side of the mass spectrometer; A medicine crushing component, which is installed on the top of the mass spectrometer and is used to crush the detected medicine; The pharmaceutical crushing assembly includes a screening box installed on the top of the mass spectrometer, a crushing box fixedly welded to the top of the screening box, a reflux lifting column installed on the top of the mass spectrometer, a crushing part installed inside the crushing box, a lifting part installed inside the reflux lifting column, a screening plate installed inside the screening box and a self-cleaning structure installed on the top of the screening plate.

[0008] Preferably, a through hole is provided on the top of the screening box, a first guide groove is provided on one side of the top of the screening plate, and the self-cleaning structure includes a column installed inside the through hole, a lifting column fixedly welded on the top of the column, a sliding block slidably connected to the inside of the first guide groove through a first guide slider, a cleaning plate fixedly welded on one side of the sliding block, and a hinge fixedly installed between the sliding block and the column.

[0009] Preferably, the hinged member includes a first hinged seat fixedly welded to the top of the sliding block, a second hinged seat fixedly welded to one side of the column, and a hinged plate hinged between the first hinged seat and the second hinged seat.

[0010] Preferably, the crushing element includes a crushing motor installed on the outside of the crushing box by bolts, a first crushing column fixedly mounted on the output shaft of the crushing motor and rotatably mounted on the inner wall of the crushing box, and a second crushing column rotatably mounted between the inner walls of the crushing box, and the first crushing column is meshed with the second crushing column.

[0011] Preferably, the lifting member includes a lifting motor installed on the top of the reflux lifting column by bolts and a spiral conveying rod fixedly installed on the output shaft of the lifting motor and rotatably installed on the inner bottom wall of the reflux lifting column, and a reflux bucket is installed between the screening box and the reflux lifting column.

[0012] Preferably, the heat dissipation structure includes a heat exchange tube installed inside the mass spectrometer and a heat sink installed on the back side of the mass spectrometer, a second guide groove is opened on the back side of the mass spectrometer, and the heat sink includes a water tank slidably connected to the inside of the second guide groove through a second guide slider, a reflux cooling box fixedly installed on the back side of the mass spectrometer, a pump body installed on the back side of the mass spectrometer by bolts, a horizontal plate fixedly welded on the back side of the mass spectrometer, and a return spring welded to the bottom of the water tank and the top of the horizontal plate.

[0013] Preferably, both ends of the pump body are connected to one end of the heat exchange tube through a pipe and to the water tank through a hose, and the reflux cooling box is connected to the other end of the heat exchange tube through a pipe and to the water tank through a hose, and a lifting rod is fixedly welded to one side of the lifting column through an L rod.

[0014] Preferably, a storage groove is provided at the bottom of the movable seat, third guide grooves are provided on both sides of the storage groove, a cylinder is installed on the top wall of the storage groove by bolts, a storage plate is fixedly installed on the output shaft of the cylinder, third guide sliders are fixedly welded on both sides of the storage plate, the third guide sliders are slidably connected to the inside of the third guide groove, and the universal wheel is installed at the bottom of the storage plate.

[0015] Compared with the prior art, the beneficial effects of the present invention are: The first pulverizing column is driven to rotate by the pulverizing motor, and the first pulverizing column meshes with the second pulverizing column to rotate to pulverize the medicine. The pulverized medicine enters the screening box, and is screened by the screening plate. Fine medicine powder enters the bottom of the screening box and is collected and used through a discharge pipe on one side. Excessive medicine particles enter the reflux lifting column through the reflux bucket, and the spiral conveying rod is driven to rotate by the lifting motor to put the medicine particles back into the pulverizing box for secondary pulverization. This cycle repeats and the qualified medicine powder can be obtained without the staff having to pulverize the medicine multiple times.

[0016] The cooling water in the water tank is introduced into the heat exchange tube through the pump body to carry out heat exchange work. The cooling water after heat exchange returns to the water tank through the reflux cooling box. As the cooling water enters and exits the water tank, the weight of the water tank first decreases and then increases. Under the action of the reset spring, the water tank drives the second guide slider to slide in the second guide groove, and the water tank completes the reciprocating lifting work. The water tank drives the column to rise and fall under the action of the lifting rod, L rod and lifting column. The column drives the second articulated seat to rise and fall. The second articulated seat drives the first articulated seat to move through the articulated plate. Under the guiding action of the first guide block, the first articulated seat drives the sliding block to move up and down along the screening plate, and then drives the cleaning plate to move through the sliding block. The cleaning plate cleans the residual drug particles on the screening plate to avoid clogging the screening plate. It completes the self-cleaning work while completing the heat dissipation work, which is simple and convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention; Figure 2 It is a schematic diagram of the three-dimensional structure of the present invention viewed from another perspective; Figure 3 It is a schematic diagram of the three-dimensional structure of the medicine crushing component in the present invention; Figure 4 It is a three-dimensional structural schematic diagram of the screening plate and the self-cleaning structure in the present invention; Figure 5 It is a three-dimensional structural schematic diagram of the heat dissipation structure in the present invention; Figure 6 It is a schematic diagram of the three-dimensional structure of the storage plate and the universal wheel in the present invention.

[0018] The numbers in the figure represent: Mass spectrometer; Mobile seat; Universal wheel; Heat dissipation structure; 401, heat exchange tube; 402, heat dissipation element; Medicine crushing assembly; 501, screening box; 502, crushing box; 503, reflux lifting column; 504, crushing piece; 505, lifting piece; 506, screening plate; 507, self-cleaning structure; 5071, column; 5072, lifting column; 5073, sliding block; 5074, cleaning plate; 5075, hinged part; The first guide groove; 7. The first hinge seat; 8. The second hinge seat; 9. The hinge plate; 10. The crushing motor; 11. The lifting motor; 12. The reflux bucket; 13. The second guide groove; 14. The water tank; 15. The reflux cooling box; 16. The pump body; 17. The horizontal plate; 18. The return spring; 19. The hose; 20. The lifting rod; 21. The L rod; 22. The cylinder; 23. The storage plate; 24. The third guide slider. DETAILED DESCRIPTION

[0019] The above and other technical features and advantages of the present invention are described in more detail below in conjunction with the accompanying drawings.

[0020] The present invention provides a technical solution: an integrated drug safety rapid detection device for drug safety detection, such as Figure 1-6 As shown, it includes a mass spectrometer 1, a heat dissipation structure 4 and a medicine crushing component 5; A moving base 2 is installed at the bottom of the mass spectrometer 1, and a universal wheel 3 is installed at the bottom of the moving base 2; A receiving groove is provided at the bottom of the mobile seat 2, and third guide grooves are provided on both sides of the receiving groove. A cylinder 22 is installed on the top wall of the receiving groove by bolts, and a receiving plate 23 is fixedly installed on the output shaft of the cylinder 22. Third guide sliders 24 are fixedly welded on both sides of the receiving plate 23. The third guide sliders 24 are slidably connected inside the third guide groove, and the universal wheel 3 is installed at the bottom of the receiving plate 23; The heat dissipation structure 4 is installed on the back side of the mass spectrometer 1; The heat dissipation structure 4 includes a heat exchange tube 401 installed inside the mass spectrometer 1 and a heat sink 402 installed on the back side of the mass spectrometer 1. A second guide groove 13 is opened on the back side of the mass spectrometer 1. The heat sink 402 includes a water tank 14 slidably connected to the inside of the second guide groove 13 through a second guide slider, a reflux cooling box 15 fixedly installed on the back side of the mass spectrometer 1, a pump body 16 installed on the back side of the mass spectrometer 1 by bolts, a horizontal plate 17 fixedly welded on the back side of the mass spectrometer 1, and a return spring 18 welded to the bottom of the water tank 14 and the top of the horizontal plate 17.

[0021] In the specific implementation, such as Figure 1-6 As shown, the drug crushing assembly 5 is installed on the top of the mass spectrometer 1, and the drug crushing assembly 5 is used to crush the detected drugs; The drug crushing assembly 5 includes a screening box 501 installed on the top of the mass spectrometer 1, a crushing box 502 fixedly welded to the top of the screening box 501, a reflux lifting column 503 installed on the top of the mass spectrometer 1, a crushing piece 504 installed inside the crushing box 502, a lifting piece 505 installed inside the reflux lifting column 503, a screening plate 506 installed inside the screening box 501 and a self-cleaning structure 507 installed on the top of the screening plate 506.

[0022] Furthermore, a through hole is provided on the top of the screening box 501, and a first guide groove 6 is provided on one side of the top of the screening plate 506. The self-cleaning structure 507 includes a column 5071 installed in the through hole, a lifting column 5072 fixedly welded to the top of the column 5071, a sliding block 5073 slidably connected to the first guide groove 6 through a first guide slider, a cleaning plate 5074 fixedly welded to one side of the sliding block 5073, and a hinge 5075 fixedly installed between the sliding block 5073 and the column 5071.

[0023] Furthermore, the hinged member 5075 includes a first hinged seat 7 fixedly welded to the top of the sliding block 5073 , a second hinged seat 8 fixedly welded to one side of the column 5071 , and a hinged plate 9 hinged between the first hinged seat 7 and the second hinged seat 8 .

[0024] Furthermore, the crushing element 504 includes a crushing motor 10 installed on the outside of the crushing box 502 by bolts, a first crushing column fixedly mounted on the output shaft of the crushing motor 10 and rotatably mounted on the inner wall of the crushing box 502, and a second crushing column rotatably mounted between the inner walls of the crushing box 502, and the first crushing column is meshed with the second crushing column.

[0025] Furthermore, the lifting member 505 includes a lifting motor 11 installed on the top of the reflux lifting column 503 by bolts and a spiral conveying rod fixedly mounted on the output shaft of the lifting motor 11 and rotatably mounted on the inner bottom wall of the reflux lifting column 503. A reflux bucket 12 is installed between the screening box 501 and the reflux lifting column 503.

[0026] Furthermore, both ends of the pump body 16 are connected to one end of the heat exchange tube 401 through a pipe and to the water tank 14 through a hose 19, and the reflux cooling box 15 is connected to the other end of the heat exchange tube 401 through a pipe and to the water tank 14 through a hose 19. A lifting rod 20 is fixedly welded to one side of the water tank 14, and the lifting rod 20 is fixedly welded to one side of the lifting column 5072 through an L rod 21.

[0027] When in use, the medicine to be tested is put into the crushing box 502, and the first crushing column is driven to rotate by the crushing motor 10. The first crushing column and the second crushing column mesh and rotate to crush the medicine. The crushed medicine enters the screening box 501, and the medicine is screened by the screening plate 506. The fine medicine powder enters the bottom of the screening box 501 and is collected and used through the discharge pipe on one side. The oversized medicine particles enter the reflux lifting column 503 through the reflux bucket 12, and the spiral conveying rod is driven to rotate by the lifting motor 11 to put the medicine particles back into the crushing box 502 for secondary crushing. This reciprocating process does not require the staff to crush the medicine multiple times to obtain qualified medicine powder. The sieved drug powder is dissolved in a suitable solvent, such as water, alcohol or organic solvent, to prepare a solution to be analyzed. If necessary, the sample can be concentrated by evaporation or other methods to increase the concentration of the target compound. The processed sample is injected into the ion source of the mass spectrometer 1 by a suitable method, such as a syringe or an automatic sampler, for analysis. The sample is excited in the ion source and converted into gas phase ions. The ions pass through the mass analyzer and are separated according to their mass / charge ratio. The detector records the ion signal passing through the mass analyzer, converts it into an electrical signal, generates a mass spectrum, and displays the ion intensity of different m / z ratios. The mass spectrum is analyzed by computer software to identify the peaks of different m / z ratios, i.e., ion signals. Library matching or quantitative calculation by standard products is used to confirm the presence and concentration of each component in the sample, and complete the rapid detection of drugs. During operation, the device generates heat, and the cooling water in the water tank 14 is introduced into the heat exchange tube 401 through the pump body 16 to perform heat exchange. The cooling water after heat exchange returns to the water tank 14 through the reflux cooling box 15. As the cooling water flows in and out of the water tank 14, the weight of the water tank 14 first decreases and then increases. Under the action of the return spring 18, the water tank 14 drives the second guide slider to slide in the second guide groove 13, and the water tank 14 completes the reciprocating lifting work. The water tank 14 is lifted and lowered by the lifting rod 20, the L rod 21 and the lifting column 5072. The column 5071 is driven to rise and fall, and the column 5071 drives the second hinged seat 8 to rise and fall. The second hinged seat 8 drives the first hinged seat 7 to move through the hinged plate 9. Under the guidance of the first guide block, the first hinged seat 7 drives the sliding block 5073 to move up and down along the screening plate 506, and then drives the cleaning plate 5074 to move through the sliding block 5073. The cleaning plate 5074 cleans the residual drug particles on the screening plate 506 to avoid clogging the screening plate 506. It completes the self-cleaning work while completing the heat dissipation work, which is simple and convenient.

[0028] The above are only preferred embodiments of the present invention, which are only illustrative and not restrictive. Those skilled in the art understand that many changes, modifications, and even equivalences may be made to the present invention within the spirit and scope defined by the claims, but all of them will fall within the scope of protection of the present invention.

Claims

1. An integrated drug safety rapid testing device for drug safety testing, characterized in that: include: A mass spectrometer (1), wherein a movable base (2) is mounted at the bottom of the mass spectrometer (1), and a universal wheel (3) is mounted at the bottom of the movable base (2); A heat dissipation structure (4), the heat dissipation structure (4) being installed on the back side of the mass spectrometer (1); A medicine crushing component (5), the medicine crushing component (5) being installed on the top of the mass spectrometer (1), and the medicine crushing component (5) being used to crush the medicine to be tested; The drug pulverizing assembly (5) comprises a screening box (501) mounted on the top of the mass spectrometer (1), a pulverizing box (502) fixedly welded to the top of the screening box (501), a reflux lifting column (503) mounted on the top of the mass spectrometer (1), a pulverizing member (504) mounted inside the pulverizing box (502), a lifting member (505) mounted inside the reflux lifting column (503), a screening plate (506) mounted inside the screening box (501), and a self-cleaning structure (507) mounted on the top of the screening plate (506).

2. The integrated drug safety rapid testing device for drug safety testing as claimed in claim 1, characterized in that: A through hole is formed at the top of the screening box (501), a first guide groove (6) is formed at one side of the top of the screening plate (506), and the self-cleaning structure (507) comprises a column (5071) installed inside the through hole, a lifting column (5072) fixedly welded to the top of the column (5071), a sliding block (5073) slidably connected to the inside of the first guide groove (6) via a first guide slider, a cleaning plate (5074) fixedly welded to one side of the sliding block (5073), and a hinge (5075) fixedly installed between the sliding block (5073) and the column (5071).

3. The integrated drug safety rapid testing device for drug safety testing as claimed in claim 2, characterized in that: The hinged member (5075) comprises a first hinged seat (7) fixedly welded to the top of the sliding block (5073), a second hinged seat (8) fixedly welded to one side of the column (5071), and a hinged plate (9) hinged between the first hinged seat (7) and the second hinged seat (8).

4. The integrated drug safety rapid testing device for drug safety testing as claimed in claim 1, characterized in that: The crushing element (504) comprises a crushing motor (10) mounted on the outside of the crushing box (502) by means of bolts, a first crushing column fixedly mounted on the output shaft of the crushing motor (10) and rotatably mounted on the inner wall of the crushing box (502), and a second crushing column rotatably mounted between the inner walls of the crushing box (502), the first crushing column meshing with the second crushing column.

5. The integrated drug safety rapid testing device for drug safety testing as claimed in claim 1, characterized in that: The lifting member (505) comprises a lifting motor (11) mounted on the top of the reflux lifting column (503) by bolts and a spiral conveying rod fixedly mounted on the output shaft of the lifting motor (11) and rotatably mounted on the inner bottom wall of the reflux lifting column (503). A reflux bucket (12) is installed between the screening box (501) and the reflux lifting column (503).

6. The integrated drug safety rapid testing device for drug safety testing as claimed in claim 2, characterized in that: The heat dissipation structure (4) comprises a heat exchange tube (401) installed inside the mass spectrometer (1) and a heat dissipation element (402) installed on the back side of the mass spectrometer (1); a second guide groove (13) is provided on the back side of the mass spectrometer (1); the heat dissipation element (402) comprises a water tank (14) slidably connected to the inside of the second guide groove (13) via a second guide slider, a reflux cooling box (15) fixedly installed on the back side of the mass spectrometer (1), a pump body (16) installed on the back side of the mass spectrometer (1) via bolts, a horizontal plate (17) fixedly welded to the back side of the mass spectrometer (1), and a return spring (18) welded to the bottom of the water tank (14) and the top of the horizontal plate (17).

7. An integrated drug safety rapid testing device for drug safety testing as claimed in claim 6, characterized in that: The two ends of the pump body (16) are respectively connected to one end of the heat exchange tube (401) through a pipeline and connected to the water tank (14) through a hose (19); the reflux cooling box (15) is respectively connected to the other end of the heat exchange tube (401) through a pipeline and communicates with the water tank (14) through a hose (19); a lifting rod (20) is fixedly welded to one side of the water tank (14); and the lifting rod (20) is fixedly welded to one side of the lifting column (5072) through an L rod (21).

8. The integrated drug safety rapid testing device for drug safety testing as claimed in claim 1, characterized in that: A receiving groove is provided at the bottom of the movable seat (2), third guide grooves are provided on both sides of the receiving groove, a cylinder (22) is installed on the top wall of the receiving groove by bolts, a receiving plate (23) is fixedly installed on the output shaft of the cylinder (22), third guide sliders (24) are fixedly welded on both sides of the receiving plate (23), the third guide sliders (24) are slidably connected inside the third guide groove, and the universal wheel (3) is installed at the bottom of the receiving plate (23).

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