Preparation process of a spray composite disinfectant

Abstract

This application relates to the field of disinfection technology, and specifically discloses a preparation process of a spray composite disinfectant. The raw materials for preparing the composite disinfectant include a disinfectant, a wetting agent, a synergist, a moisturizing auxiliary agent, a solvent, and water. The specific preparation steps are as follows: Add the disinfectant and the wetting agent to the solvent, disperse evenly, then add the synergist, the moisturizing auxiliary agent, and water, and disperse evenly to obtain the product. Among them, the wetting agent uses poly-α-olefin sulfonate. The spray composite disinfectant provided by this application has good formulation dispersibility, stable storage without stratification, and is suitable for both automatic spray disinfection and manual spray disinfection. It has excellent disinfection and sterilization effects, and will not cause a sharp increase in the content of microorganisms in the air within a short time of disinfection.

Description

Technical Field

[0001] The present application relates to the field of disinfection technology, and more specifically, to a preparation process of a spray composite disinfectant. Background Art

[0002] With the intensive and large-scale development of livestock and poultry farming, the management of livestock and poultry farming environment has become increasingly important. Among them, disinfection is a key measure to prevent and control livestock and poultry infectious diseases, and its importance is self-evident. Spray disinfection, as a disinfection method, has been widely used in livestock and poultry farming because of its high efficiency, convenience, and ability to quickly reduce the content of pathogenic microorganisms.

[0003] Spray disinfection sprays disinfectants in the form of mist, so that the disinfectants can fully contact every corner of the poultry house, including the air, ground, walls, cages and the surface of livestock and poultry, thereby effectively killing pathogenic microorganisms, reducing their content, and reducing the chance of livestock and poultry contacting pathogens, thereby controlling the spread of diseases. In addition, some acidic disinfectants can also neutralize ammonia in the poultry house, reduce the dust content in the air, and reduce irritation to livestock and poultry. In the hot summer, spray disinfection can also promote evaporative heat dissipation and play a cooling role.

[0004] Spray disinfection is a widely used disinfection method, which is favored because of its simple operation, wide coverage and high disinfection efficiency. However, in actual application, the use of livestock and poultry spray disinfectants also faces a series of challenges, especially the technical problem of "spraying easily leads to a surge in the content of microorganisms in the air", which has become a key point to be solved urgently.

[0005] Traditional livestock and poultry spray disinfectants are mostly chemical preparations, such as sodium hypochlorite, peracetic acid, quaternary ammonium salts, etc. While these disinfectants kill pathogenic microorganisms, they may also cause the content of microorganisms (including bacteria, viruses, fungi, etc.) in the air to rise rapidly in a short period of time due to the droplets and aerosols generated during the spraying process. In addition, some disinfection methods have limitations, such as manual spray disinfection. The water mist droplets sprayed from the nozzle are generally large in particle size and have poor atomization effect. The water mist sprayed from the nozzle hammers the ground, walls, equipment, etc., causing dust and dust to rise, resulting in an increase in the content of air microorganisms after disinfection, even higher than before disinfection. The occurrence of this phenomenon may not only weaken the disinfection effect, but also irritate the respiratory system of livestock and poultry, increase the risk of livestock and poultry diseases, and even pose a threat to the health of human operators.

[0006] In response to this problem, the industry has begun to explore the preparation process and disinfection methods of livestock and poultry spray composite disinfectants that can reduce the microbial content in the air. The research focuses on developing new disinfectant components, optimizing disinfectant formulations, improving spraying devices, and enhancing spraying techniques. For example, in the preparation process, technologies such as microencapsulation and nanonization are used to improve the stability and dispersibility of disinfectants, enabling them to cover the target area more evenly during spraying and reducing the generation of droplets and aerosols. In the disinfection process, the development of intelligent spraying systems, through precise control of spraying time, frequency, and quantity, as well as optimizing the spraying path, to achieve the precise application of disinfectants, is also an effective way to solve the problem of the sharp increase in the microbial content in the air.

[0007] Whether it is microencapsulation, nanonization, or the development of intelligent spraying systems, they will all lead to the complication of the formula of spray composite disinfectants and an increase in the cost of disinfection equipment. For the technical problem that the spraying of livestock and poultry spray disinfectants is prone to cause a sharp increase in the microbial content in the air, a simple, effective, and reliable method is still needed to solve it. Summary of the Invention

[0008] To solve the above technical problems, the present application provides a preparation process for a spray composite disinfectant, which has good formula dispersibility, stable storage without stratification, is suitable for both automatic spray disinfection and manual spray disinfection, has excellent disinfection and sterilization effects, and will not cause a sharp increase in the microbial content in the air in a short time during disinfection.

[0009] The preparation process for a spray composite disinfectant provided by the present application adopts the following technical scheme:

[0010] A preparation process for a spray composite disinfectant, the raw materials for preparing the composite disinfectant include a disinfectant, a wetting agent, a synergist, a moisturizing aid, a solvent, and water. The specific preparation steps are as follows: Add the disinfectant and the wetting agent to the solvent, disperse evenly, and then add the synergist, the moisturizing aid, and water, and disperse evenly to obtain it.

[0011] Among them, the wetting agent uses poly-α-olefin sulfonate, preferably sodium poly-α-olefin sulfonate.

[0012] When a disinfectant with weak wetting ability is sprayed onto dust, it is easy to form encapsulated beads, and the dust that is not wetted by the disinfectant is prone to fly up, resulting in a short-term increase rather than a decrease in the microbial content in the air. The sodium poly-α-olefin sulfonate provided by the present application has a measured contact angle of 32.30° on the surface of a coal block. It has extremely strong wetting ability, high surface activity, and can well reduce the interfacial energy. After the atomized disinfectant contacts the ground, walls, and equipment, it can instantly wet the surface of the dust, making it not prone to fly-up phenomena. Moreover, sodium poly-α-olefin sulfonate has excellent dispersion and anti-hard water capabilities, is compatible with each raw material component such as the disinfectant, and the prepared composite disinfectant has stable storage without stratification.

[0013] Preferably, based on mass percentage, the raw materials of the composite disinfectant include: 5-10% of disinfectant, 10-15% of wetting agent, 5-10% of synergist, 5-10% of moisture retention aid, 5-10% of solvent, and the balance of water.

[0014] Preferably, based on mass percentage, the raw materials of the composite disinfectant include: 10% of disinfectant, 12% of wetting agent, 8% of synergist, 8% of moisture retention aid, 8% of solvent, and 54% of water.

[0015] Preferably, the carbon chain length of the poly(α-olefin sulfonate) is C 12 -C 20 . More preferably, the carbon chain length of the poly(α-olefin sulfonate) is C 12 -C 20 . The structure of the poly(α-olefin sulfonate) contains a C-S linkage form, has good chemical stability, and at the same time contains hydrophilic groups such as -SO3H and -OH on the molecular chain, and has certain surface activity and reactivity.

[0016] Furthermore, the preparation method of the sodium poly(α-olefin sulfonate) is as follows: Mix sodium α-olefin sulfonate, a chain transfer agent, and deionized water, add an initiator under heating and stirring conditions, raise the temperature for the first time and keep it warm for a period of time, then raise the temperature for the second time and keep it warm for a period of time, cool after the reaction is completed, adjust the pH to neutral, and perform vacuum distillation to remove deionized water to obtain sodium poly(α-olefin sulfonate).

[0017] Preferably, based on sodium α-olefin sulfonate, the mass fraction of the chain transfer agent is 0.5-1%, preferably 0.7%.

[0018] Preferably, based on sodium α-olefin sulfonate, the mass fraction of the initiator is 1-5%, preferably 4%.

[0019] Preferably, the chain transfer agent is at least one of phosphite, hypophosphite, dodecyl mercaptan, organotin compound, mercaptopropionic acid, and sodium methallyl sulfonate. Specifically, the chain transfer agent is sodium hypophosphite.

[0020] Preferably, the initiator is at least one of peroxide, azo compound, n-butyllithium, and Lewis acid. Specifically, the initiator is benzoyl peroxide.

[0021] Preferably, the heating temperature after mixing sodium α-olefin sulfonate, the chain transfer agent, and deionized water is 65-75°C, preferably 70°C.

[0022] Preferably, the temperature after the first temperature rise is 70-80°C, preferably 75°C; the holding time is 1-3 h, preferably 2 h.

[0023] Preferably, the temperature after the second temperature increase is 75-85°C, preferably 80°C; the heat preservation time is 1-3 h, preferably 1.5 h.

[0024] Preferably, the CMC of the sodium α-olefin sulfonate monomer is 3.1×10 -2 mol / L, and the CMC of the poly(sodium α-olefin sulfonate) is 6.2×10 -2 mol / L.

[0025] Preferably, the disinfectant is at least one of quaternary ammonium salt compounds, slightly acidic electrolyzed water, peroxide compounds, and biguanide compounds. More preferably, the disinfectant is a quaternary ammonium salt compound or slightly acidic electrolyzed water.

[0026] Furthermore, the quaternary ammonium salt compound is a double-chain quaternary ammonium salt compound, and the double-chain quaternary ammonium salt compound includes but is not limited to at least one of dioctyl quaternary ammonium salt, didecyl quaternary ammonium salt, didodecyl quaternary ammonium salt, octyl decyl quaternary ammonium salt, didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium bromide, dioctyl dimethyl ammonium chloride, dioctyl dimethyl ammonium bromide, ditridecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, ditridecyl dimethyl ammonium bromide, didodecyl dimethyl ammonium bromide, and distearyl dimethyl ammonium bromide.

[0027] Furthermore, the slightly acidic electrolyzed water is obtained by electrolyzing 2-6% dilute hydrochloric acid, with a pH of 5.0-6.5 and an effective chlorine concentration of 10-30 ppm.

[0028] Preferably, the synergist is one or a mixture of two or more of propylene glycol, pentylene glycol, decylene glycol, and p-hydroxyacetophenone.

[0029] Preferably, the moisturizing adjuvant is at least one of sorbitol, xylitol, urea, 1,2-propylene glycol, polypropylene glycol, and glycerol.

[0030] Preferably, the solvent is at least one of water, ethanol, ethylene glycol, propylene glycol, and glacial acetic acid. Among them, the water can be tap water, spring water, underground well water, drinking purified water, deionized water, etc., preferably drinking purified water and deionized water.

[0031] Furthermore, in some embodiments, common fragrances, cosolvents, etc. in the market can also be added to the composite disinfectant. The fragrance can be synthetic or natural plant extract, etc., and the cosolvent can be hydrogenated castor oil or fragrance cosolvent, etc.

[0032] Preferably, the pH value of the composite disinfectant provided by this application is 4-10.

[0033] Preferably, the composite disinfectant provided by the present application can be used directly or after dilution with water. When diluted with water, the dilution ratio V / V is 1:(50 - 100).

[0034] In summary, the beneficial effects of the present application are as follows: The present application uses sodium poly(α-olefin sulfonate) as a wetting agent, which not only has good dispersion effect on raw material components, but also the prepared composite disinfectant is stable and does not delaminate, and has good bactericidal and disinfection effects. Especially, it has a high bactericidal rate for air microorganisms in livestock and poultry houses and will not cause the problem of a sharp increase in the content of air microorganisms in a short time after disinfection. In addition, the formula of the present application is simple, without the need for encapsulation or nanosizing, and is suitable for both automatic spray disinfection and manual spray disinfection. Detailed Embodiments

[0035] The present application will be further described in detail below with reference to the embodiments.

[0036] Preparation Example: Preparation of Sodium Poly(α-olefin Sulfonate): Mix 200 g of α-olefin sulfonate monomer (purchased from Shenyang Yilaipukes Chemical Co., Ltd., C 14 -C 16 ), 1.4 g of sodium hypophosphite chain transfer agent and 200 mL of deionized water, heat to 70 °C and add 8 g of benzoyl peroxide initiator under stirring conditions, raise the temperature to 75 °C and keep it warm for 2 h, then raise the temperature to 80 °C and keep it warm for 1.5 h. After the reaction is completed, cool to 30 °C, adjust the pH to 7.5 with 20% sodium hydroxide aqueous solution, and carry out vacuum distillation to remove deionized water to obtain sodium poly(α-olefin sulfonate). After testing, the CMC value is 6.2×10 -2 mol / L.

[0037] Example 1: A spray composite disinfectant. The specific preparation steps are as follows: According to the ratios of each group in Table 1, add the disinfectant and the wetting agent to the solvent, disperse evenly, then add the synergist, the moisture retention aid, and water, and disperse evenly to obtain the spray composite disinfectant with a total mass of 1 kg.

[0038] In this example, the disinfectant uses didecyldimethylammonium chloride, the synergist uses p-hydroxyacetophenone, the moisture retention aid uses 1,2-propanediol, the solvent uses ethanol, the water uses drinking purified water, and the wetting agent uses the sodium poly(α-olefin sulfonate) prepared in the preparation example.

[0039] Example 2: A spray composite disinfectant. The specific preparation steps are as follows: According to the ratios of each group in Table 1, add the disinfectant and the wetting agent to the solvent, disperse evenly, then add the synergist, the moisture retention aid, and water, and disperse evenly to obtain the spray composite disinfectant with a total mass of 1 kg.

[0040] In this embodiment, the disinfectant is dioctyldimethylammonium chloride, the synergist is propylene glycol, the moisturizing adjuvant is urea, the solvent is ethylene glycol, the water is drinking purified water, and the wetting agent is sodium poly(alpha-olefin sulfonate) prepared in the preparation example.

[0041] Example 3: A spray composite disinfectant. The specific preparation steps are as follows: According to the ratios of each group in Table 1, add the disinfectant and the wetting agent to the solvent, disperse evenly, then add the synergist, the moisturizing adjuvant, and the water, and disperse evenly to obtain the spray composite disinfectant with a total mass of 1 kg.

[0042] In this embodiment, the disinfectant is a mixture composed of dodecyl quaternary ammonium salt and dimethyldioctadecylammonium chloride in a ratio of 1:1, the synergist is p-hydroxyacetophenone, the moisturizing adjuvant is 1,2-propanediol, the solvent is ethanol, the water is drinking purified water, and the wetting agent is sodium poly(alpha-olefin sulfonate) prepared in the preparation example.

[0043] Example 4: A spray composite disinfectant. The raw materials and preparation process in the formula are the same as those in Example 1. The difference from Example 1 is that the dosages of the raw materials in the formula are different. For the specific dosages, refer to Table 1.

[0044] Example 5: A spray composite disinfectant. The raw materials and preparation process in the formula are the same as those in Example 1. The difference from Example 1 is that the dosages of the raw materials in the formula are different. For the specific dosages, refer to Table 1.

[0045] Example 6: A spray composite disinfectant. The raw materials and preparation process in the formula are the same as those in Example 1. The difference from Example 1 is that the dosages of the raw materials in the formula are different. For the specific dosages, refer to Table 1.

[0046] Example 7: A spray composite disinfectant. The raw materials and preparation process in the formula are the same as those in Example 1. The difference from Example 1 is that the dosages of the raw materials in the formula are different. For the specific dosages, refer to Table 1.

[0047] Table 1

[0048]

[0049] Comparative Example 1: A spray composite disinfectant. The difference from Example 1 is that alpha-olefin sulfonate is used to replace sodium poly(alpha-olefin sulfonate) in Example 1.

[0050] Comparative Example 2: A spray composite disinfectant. The difference from Example 1 is that sodium dodecyl sulfonate is used to replace sodium poly(alpha-olefin sulfonate) in Example 1.

[0051] Comparative Example 3: A spray composite disinfectant. The difference from Example 1 is that fatty alcohol polyoxyethylene ether AEO-9 is used to replace sodium poly(alpha-olefin sulfonate) in Example 1.

[0052] Test 1. Appearance stability test: The composite disinfectants prepared in each example and comparative example were respectively filled in airtight containers and placed in an incubator at 54°C. After 14 days, their states were observed. Qualified: No change in color, showing a uniform, clear and transparent state, without precipitation or suspended matter, and good appearance stability.

[0053] Test 2. Foaming test: 25 mL of the composite disinfectant prepared in each example was respectively taken into a 100-mL stoppered graduated cylinder, vibrated 30 times at a speed of 2 times per second, and then left to stand for 5 min. Observe the volume V of the foam, and record the results in Table 2 below.

[0054] Test 3. Chicken coop disinfection test: A chicken coop with a length, width and height of 100 m × 10 m × 3.3 m was used as the disinfection area, and disinfection operations were carried out by means of manual spraying. Along the long path of the chicken coop, first walk forward with the nozzle facing down for floor disinfection for 2 min, then turn back and swing the nozzle up, down, left and right for wall and equipment disinfection for 3 min. Sampling: Sampling was carried out by the natural sedimentation method. Nutrient agar culture dishes were placed diagonally in the chicken coop, and the sampling time was 5 min. The culture dishes were placed in an incubator at 37°C and incubated for 24 h, and then the total number of bacteria was recorded. Calculate the bactericidal rate of the disinfectant and record it in Table 2. The bactericidal rate (%) = (number of colonies before disinfection - number of colonies after disinfection) / number of colonies before disinfection × 100%. When the bactericidal rate > 0, it indicates that the content of air microorganisms decreases after disinfection; when the bactericidal rate < 0, it indicates that the content of air microorganisms increases after disinfection.

[0055] Table 2

[0056]

[0057] It can be seen from the test results in Table 2 that the selection of wetting agents has a significant impact on the air disinfection effect. It can be seen from the test results of Comparative Examples 1-3 that for the manual disinfection method in livestock and poultry houses, the general disinfectant-surfactant system will cause the content of air microorganisms to increase rather than decrease in a short period of time. In the examples of the present application, poly(α-olefin sulfonate) is used as the wetting agent, which has good dispersibility and good wetting dust effect, thus solving this problem. It can be seen from the test results of Examples 1-3 that although poly(α-olefin sulfonate) can solve the problem of the short-term increase in air microorganisms after disinfection, the selection of different disinfectants determines the final bactericidal effect of the spray composite disinfectant. Therefore, more appropriate selection can be made according to the cost of the disinfectant and the impact of the disinfectant on humans and livestock and poultry.

[0058] Comparing the test results of Examples 1 and 4-7, it can be seen that it is better to control the dosage of the wetting agent at 10-15%, and the optimal dosage is 12%. This is because when the dosage is low, the wetting and dispersing properties of sodium poly(α-olefin sulfonate) play a limited role, making it difficult to quickly wet the dust during the spraying of the composite disinfectant. As the dosage increases, the foaming phenomenon of sodium poly(α-olefin sulfonate) becomes stronger. However, for spray composite disinfection, stronger foaming will instead affect the disinfection effect in the air. Because stirring is required during on-site preparation and the foam cannot dissipate in a short time, when spraying for disinfection, droplets will be generated, resulting in a poor disinfection effect and still an upward trend in the content of microorganisms in the air.

[0059] The above are only the preferred embodiments of the present application, and the protection scope of the present application is not limited to the above embodiments. All technical solutions falling within the idea of the present application belong to the protection scope of the present application. It should be pointed out that for those of ordinary skill in the art, several improvements and refinements made without departing from the principle of the present application should also be regarded as within the protection scope of the present application.

Claims

1. A preparation process of a spray composite disinfectant, characterized in that, The raw materials for preparing the composite disinfectant include, by mass percentage: 5-10% of disinfectant, 10-15% of wetting agent, 5-10% of synergist, 5-10% of moisture retention aid, 5-10% of solvent, and the balance of water. The specific preparation steps are as follows: Add the disinfectant and the wetting agent into the solvent, disperse evenly, then add the synergist, the moisture retention aid, and water, and disperse evenly to obtain the product. The wetting agent is poly-α-olefin sulfonate, and the disinfectant is a quaternary ammonium salt compound.

2. The preparation process of the spray composite disinfectant according to claim 1, characterized in that, The poly-α-olefin sulfonate is sodium poly-α-olefin sulfonate, and the carbon chain length of the sodium poly-α-olefin sulfonate is C 12 -C 20 .

3. The preparation process of the spray composite disinfectant according to claim 2, characterized in that, The carbon chain length of the sodium poly(α-olefin sulfonate) is C 14 -C 16 .

4. The preparation process of the spray composite disinfectant according to claim 1, characterized in that, The raw materials of the composite disinfectant include, by mass percentage: 10% of disinfectant, 12% of wetting agent, 8% of synergist, 8% of moisture retention aid, 8% of solvent, and 54% of water.

5. The preparation process of the spray composite disinfectant according to claim 1, characterized in that, The synergist is a mixture composed of one or more of propylene glycol, pentylene glycol, decylene glycol, and p-hydroxyacetophenone.

6. The preparation process of the spray composite disinfectant according to claim 1, wherein, The moisture retention aid is at least one of sorbitol, xylitol, urea, 1,2-propylene glycol, polypropylene glycol, and glycerol.

7. The preparation process of the spray composite disinfectant according to claim 1, characterized in that, The solvent is at least one of water, ethanol, ethylene glycol, propylene glycol, and glacial acetic acid.

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