Application method of ablation system and ablation system

Abstract

The invention provides a use method of an ablation system and the ablation system. According to the ablation system, the ablation device and the imaging device are arranged on the same optical path, and the ablation device is guided to move to the lesion position of the region of interest in real time through the imaging device; meanwhile, when the ablation device is used for lesion ablation, the ablation condition of the lesion position can be monitored through the imaging device, so that the ablation system is highly integrated, and application of the ablation system is facilitated. Meanwhile, the ablation system is controlled to perform work calibration through the calibration device before ablation is started, so that the imaging accuracy of the imaging device can be ensured; furthermore, by controlling the matching relation between the imaging device and the ablation device, an image of the working area can be obtained in real time through the imaging device, and ablation of the ablation device can be completed conveniently; meanwhile, the ablation effect can be evaluated through the imaging device after ablation is completed, and the safety and completeness of ablation are guaranteed.

Description

Technical Field

[0001] The present invention relates to a method for using an ablation system and an ablation system using the method for using the ablation system, and belongs to the field of interventional treatment medical devices. Background Art

[0002] Atherosclerosis is a serious and common vascular disease that mainly occurs in the coronary arteries and lower limb arteries. Its clinical manifestation is the deposition of atherosclerotic plaques on the blood vessel walls. These plaques are usually composed of lipid deposits, inflammatory cells, calcified substances, thrombi and other substances. Over time, plaques may gradually increase in size and cause arterial hardening, narrowing, or even occlusion, leading to ischemic lesions in the corresponding organs.

[0003] At present, percutaneous vascular intervention technology has become the most widely used treatment for atherosclerotic lesions due to its minimally invasive nature, short operation time and rapid postoperative recovery. Intravascular laser ablation technology is one of the plaque reduction technologies. When implementing this technology, the ablation catheter is generally delivered to the lesion site first, and then the laser is emitted from the tip to the lesion to ablate it, thereby restoring blood flow at the stenosis.

[0004] Percutaneous vascular intervention is generally performed under the guidance of angiography, which can provide the overall morphology of the blood vessels but cannot indicate the nature of the plaque and its boundary with the vascular wall. In addition, angiography is easily affected by anatomical overlap and vascular tortuosity, resulting in poor evaluation of certain lesions.

[0005] In recent years, with the emergence of intracavitary imaging, it has become possible to accurately provide the location and properties of plaques during surgery. Among them, OCT uses near-infrared light to generate high-resolution images, which can well identify the morphological and structural characteristics of plaques, and has important guiding significance for the selection of interventional treatment plans and the evaluation of their effects.

[0006] However, the current clinical laser ablation technology can only rely on traditional angiography for real-time guidance, and there is no real-time intracavitary imaging to determine the vascular boundary and volume reduction, which is the main reason for the high incidence of complications such as perforation and dissection. Even if no adverse events occur, the damage to the vascular wall caused by improper volume reduction can also cause retaliatory vascular restenosis, affecting the long-term efficacy.

[0007] In view of this, it is indeed necessary to provide a method for using an ablation system and an ablation system using the method for using the ablation system to solve the above problems. Summary of the invention

[0008] The object of the present invention is to provide a method for using an ablation system and an ablation system using the method for using the ablation system. The ablation system guides ablation by using a high-resolution imaging device, and the ablation device and the imaging device share the same optical path. While the ablation system is highly integrated, it ensures that the imaging field of view of the imaging device is the same as the ablation field of the ablation device, and can then accurately provide information such as the nature and orientation of the lesion in the area of ​​interest.

[0009] To achieve the above-mentioned object of the invention, the present invention provides a method for using an ablation system, wherein the ablation system comprises an ablation device, an imaging device, and a coupling device for coupling an imaging beam of the imaging device into an optical fiber of an ablation catheter of the ablation device; the method for using the ablation system comprises the following steps:

[0010] S1, controlling the operation of an imaging device, wherein the imaging device obtains a real-time image of the region of interest through the optical fiber, and guides the ablation catheter to move to the region of interest;

[0011] S2. Positioning and identifying the lesion position of the region of interest according to the real-time image, and adjusting the working position of the ablation catheter so that the working position overlaps with the lesion position;

[0012] S3. Control the ablation device to perform ablation, so that the ablation beam and / or the imaging beam acts on the lesion location through the optical fiber, and ablates and / or images the lesion at the lesion location.

[0013] As a further improvement of the present invention, the ablation device includes an ablation light source, a beam transmission optical path and an ablation catheter, the ablation catheter includes a front end rigid part and a rear end flexible part, the front end rigid part includes at least an outer shell, an actuator and an optical fiber cantilever; the rear end flexible part includes an optical fiber, a conductive cable and a sheath.

[0014] As a further improvement of the present invention, the fiber optic cantilever is a part of the optical fiber, and the optical fiber passes through the actuator to extend on one side of the actuator to form the fiber optic cantilever; so that one end of the fiber optic cantilever is fixed on the actuator and the other end extends away from the actuator.

[0015] As a further improvement of the present invention, before S1, the method for using the ablation system also includes S0, and S0 is: under a preset voltage, controlling the actuator in the ablation catheter to drive the optical fiber cantilever in the ablation catheter to perform a scanning motion, moving the ablation catheter to face the calibration device, and completing the calibration of the ablation device.

[0016] As a further improvement of the present invention, the calibration device includes a position sensor, which can collect the scanning trajectory coordinates of the light beam emitted from the front end of the ablation catheter within a movement cycle, and calibrate the ablation device through image calibration.

[0017] As a further improvement of the present invention, S2 also includes: performing image feature analysis on the real-time image to determine whether the ablation device deviates from the lesion position during movement, guiding and adjusting the ablation catheter to move to a position facing the lesion position, and analyzing the lesion type at the lesion position based on the real-time image.

[0018] As a further improvement of the present invention, in S3, controlling the ablation device to perform ablation work includes:

[0019] The energy of the ablation beam emitted by the ablation device is adjusted according to the lesion type at the lesion location; and the regional properties of the region of interest where the ablation catheter is located are identified according to the real-time image, and the operating state of the imaging device is adjusted based on the regional properties.

[0020] As a further improvement of the present invention, when the regional property is complex, the imaging device is controlled to operate in real time, the imaging device acquires the real-time image of the region of interest through the ablation catheter in real time, and adjusts the orientation of the ablation catheter based on the real-time image;

[0021] When the regional property is a simple property, the imaging device is controlled to obtain the real-time image of the region of interest after the ablation device ablates for a preset time or after ablation is completed, so as to evaluate the ablation effect.

[0022] To achieve the above-mentioned object of the invention, the present invention further provides an ablation system for executing the above-mentioned method for using the ablation system, wherein the ablation system comprises:

[0023] The ablation device comprises an ablation catheter, an ablation light source and a light beam transmission path; the ablation light source provides an ablation light beam and transmits it to the ablation catheter through the light beam transmission path to complete lesion ablation;

[0024] An imaging device, including an OCT imaging light source and an interferometer assembly, for providing an imaging beam;

[0025] A coupling device, used to combine the imaging light beam of the imaging device and the ablation light beam of the ablation device, and couple them into the optical fiber in the ablation catheter;

[0026] A driving device, used for generating a voltage signal, and applying the voltage signal to an actuator in the ablation catheter through a conductive cable, and driving the actuator to generate displacement;

[0027] The control device is used to control the operation of the imaging device and the ablation device, so as to obtain an image of the region of interest through the imaging device, and to complete the ablation of the lesion at the lesion position through the ablation device.

[0028] As a further improvement of the present invention, the ablation system further includes a calibration device;

[0029] The calibration device is used to collect the coordinates of the front-end light beam scanning trajectory of the ablation catheter for calibrating image distortion.

[0030] As a further improvement of the present invention, the ablation light source is a laser light source, the wavelength of the ablation light source is ultraviolet to infrared light, and the pulse width can be from femtoseconds to continuous light.

[0031] The beneficial effects of the present invention are:

[0032] The ablation system of the present invention sets the ablation device and the imaging device in the same optical path, and guides the ablation device to move to the lesion position in the region of interest in real time through the imaging device; at the same time, when the ablation device is used to ablate the lesion, the ablation situation at the lesion position can also be monitored through the imaging device, so that the ablation system is highly integrated and convenient for the application of the ablation system. At the same time, by controlling the calibration of the ablation system through the calibration device before the ablation begins, the accuracy of the imaging of the imaging device can be guaranteed, and then it is convenient to accurately judge the regional properties of the region of interest or the lesion properties of the lesion position in the region of interest through the images collected by the imaging device; further, by controlling the coordination relationship between the imaging device and the ablation device, the image of the working area can be obtained in real time through the imaging device, which is convenient for the ablation device to complete ablation; at the same time, the ablation effect can also be evaluated through the imaging device after the ablation is completed, so as to ensure the safety and completeness of the ablation. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 It is a schematic block diagram of the structure of the ablation system of the present invention.

[0034] Figure 2 yes Figure 1 Schematic diagram of the structure of the ablation catheter.

[0035] Figure 3 is a flow chart of a method for using the ablation system of the present invention. DETAILED DESCRIPTION

[0036] Embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention.

[0037] In the description of the present invention, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0038] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0039] In order to make the purpose, technical solutions and advantages of the present invention more clear, the present invention is described in detail below with reference to the accompanying drawings and specific embodiments.

[0040] When atherosclerotic lesions develop to a certain extent, the blood vessels may be completely blocked, resulting in blockage of forward blood flow, which is called chronic total occlusion (CTO). When opening CTO lesions clinically, guidewire puncture is required first, and the difficulty lies in breaking through the proximal fiber cap of the CTO lesion. However, the position of the proximal fiber cap is unclear under angiography, and it is often accompanied by hard calcification. If the puncture is performed blindly at this time, it is very likely to cause arterial perforation. If it can be combined with real-time intracavitary imaging, a small hole can be ablated at the fiber cap, thereby providing a puncture breakthrough point for the guidewire, which will reduce the probability of arterial perforation and dissection.

[0041] The ablation system 100 provided by the present invention, by setting the ablation device 1 and the imaging device 2 in the same optical path, can accurately control the ablation direction and volume through the imaging device 2 when using the ablation device 1 to ablate and reduce the volume or modify the CTO fiber cap, thereby ultimately reducing the probability of vascular wall damage and other adverse complications.

[0042] See also Figure 1 As shown, the ablation system 100 provided by the present invention includes: an ablation device 1, an imaging device 2, a coupling device 3 and a control device 4. The ablation system 100 also includes a driving device 5 and a calibration device 6, wherein the control device 4 is used to control the operation of the ablation device 1 and the imaging device 2 to obtain an image of the region of interest through the imaging device 2, and complete the ablation of the lesion at the lesion position through the ablation device 1.

[0043] The ablation device 1 includes an ablation catheter 11, an ablation light source 12, and a beam transmission optical path 13; wherein the ablation light source 12 provides an ablation beam and transmits it to the ablation catheter 11 through the beam transmission optical path 13 to complete the ablation of the lesion. Figure 2 As shown, the ablation catheter 11 includes a front rigid portion and a rear flexible portion.

[0044] Specifically, the front rigid part includes a housing 111, an actuator 112 and a fiber cantilever 113, wherein the housing 111 is used to fix the actuator 112 so that the actuator 112 and the fiber cantilever 113 are coaxially or approximately coaxially placed in the housing 111. In the present disclosure, the actuator 112 may be any one of a piezoelectric actuator, a 2D piezoelectric ceramic, a piezoelectric vibrator and a piezoelectric bending sheet. In order to realize the scanning of the fiber cantilever 113 in two directions, it may preferably be a piezoelectric ceramic tube or a 2D piezoelectric ceramic. It should be noted that in the present disclosure, the actuator 112 is only illustrated as a piezoelectric actuator. In other embodiments of the present disclosure, the actuator used to drive the fiber cantilever 113 may also be an electromagnetic, electrostatic, or other type of actuator.

[0045] One end of the fiber optic cantilever 113 is fixed on the actuator 112, and the other end extends a certain length away from the actuator 112 so as to be suspended and fixed in the center in the internal cavity of the housing 111; further, the actuator 112 can cause the fiber optic cantilever 113 to displace under the drive of a voltage, and drive the fiber optic cantilever 113 to vibrate at a resonant frequency. In fact, as the length of the fiber optic cantilever 113 is longer, the vibration amplitude will also be greater, but the increase in vibration amplitude will lead to a decrease in the resonant frequency of the optical fiber during vibration, and a resonant frequency that is too low may cause uneven optical fiber vibration scanning, affecting the imaging effect of the imaging device 2 and the ablation effect of the ablation device 1. Based on this, in the present disclosure, the fiber optic cantilever 113 is generally a few millimeters to tens of millimeters. It should be noted that in the specification of the present disclosure, only the actuator 112 is used to drive the fiber optic cantilever 113 to vibrate at a resonant frequency as an example. In other embodiments of the present disclosure, the fiber optic cantilever 113 can also vibrate at other frequencies driven by the actuator 112, that is, the frequency of the fiber optic cantilever 113 vibrating under the drive of the actuator 112 can be selected according to actual needs.

[0046] In the present disclosure, the front rigid part also includes a focusing structure disposed at the extended end of the optical fiber cantilever 113, so as to focus the light beam passing through the optical fiber cantilever 113. Figure 2 As shown, in a preferred embodiment of the present disclosure, the focusing structure includes at least one of a fiber optic probe 114 and a micro lens 115 .

[0047] Specifically, the fiber probe 114 is a fiber-type lens, which is used to focus the light beam. In a preferred embodiment of the present disclosure, the fiber probe 114 is a fiber-type ball lens formed at the end of the fiber cantilever 113, which is formed by burning a coreless optical fiber of a certain length extending from the end of the fiber cantilever 113, and then focusing the light beam is achieved. In other embodiments of the present disclosure, the fiber probe 114 can also be a micro lens fixed to the end of the fiber cantilever 113 by welding or bonding, such as a fiber-type or micro GRIN lens, a 3D printed lens, a fiber-type super lens, and for simplicity, it can be preferably a fiber-type ball lens or a fiber-type GRIN lens.

[0048] The micro lens 115 is fixed at the front end of the housing 111 and is used to expand the scanning range of the light beam to achieve the purpose of expanding the ablation range to the outer diameter of the catheter. In the present disclosure, the micro lens 115 can be one of a GRIN lens, a super lens, and a composite lens. The preferred micro lens 115 is a GRIN lens to effectively reduce the difficulty of preparing the ablation catheter 11.

[0049] It should be noted that when the front-end rigid part includes the optical fiber probe 114 and / or the micro lens 115 , the actuator 112 , the optical fiber cantilever 113 , the optical fiber probe 114 , and the micro lens 115 are all coaxially or approximately coaxially placed in the housing 111 .

[0050] The rear flexible part includes an optical fiber 116, a conductive cable 117, and a sheath 118. Specifically, the optical fiber 116, the conductive cable 117, and the sheath 118 in the rear flexible part have a certain length. In the present disclosure, the total length of the optical fiber 116, the conductive cable 117, and the sheath 118 is about 1 to 2 meters to meet the application scenario of vascular intervention surgery.

[0051] Optical fiber 116 is a reverse extension of the optical fiber cantilever 113, that is, the optical fiber cantilever 113 is a part of the optical fiber 116; in the present disclosure, the optical fiber 116 can be any one of a single-mode optical fiber, a double-clad optical fiber, and a photonic crystal fiber, and the specific selection of the optical fiber 116 can be determined according to the light source type of the ablation light source 12.

[0052] The extended end of the conductive cable 117 is fixed on the actuator 112 for transmitting voltage signals, and the number is not limited to one; the sheath 118 is used to protect the optical path and circuit inside the ablation catheter 11 .

[0053] During the operation of the ablation catheter 11, the surface of the actuator 112 (specifically a piezoelectric ceramic tube) has four partition electrodes and a ground electrode, and each electrode is connected to a conductive cable. When the driving device 5 applies a voltage of a certain frequency to the actuator 112 through the conductive cable, the actuator 112 will produce displacements in two directions and drive the optical fiber cantilever 113 to perform scanning motion at a resonant frequency, and the scanning trajectory is controlled by the applied voltage. The micro lens 115 at the front end of the ablation catheter 11 further expands the scanning range of the light beam, so that the ablation range of the ablation catheter 11 is not less than the outer diameter of the housing 111.

[0054] The ablation light source 12 is used to direct the light beam to the lesion position of the region of interest through the ablation catheter 11 to achieve ablation of the lesion. In the present disclosure, the wavelength of the laser light source selected by the ablation light source 12 can be ultraviolet to infrared light, and the pulse width can be femtosecond to continuous light; preferably, the ablation light source 12 is an ultrafast laser or a light source with a pulse width of less than 100ps, so that a high peak power density light beam can be provided to achieve a better ablation effect on calcified plaques.

[0055] The light beam transmission optical path 13 can be flexibly arranged according to the requirements, and should not only realize the function of light beam transmission, but also realize one or several functions such as light beam shaping, pulse adjustment, light spot homogenization, and energy adjustment.

[0056] The imaging device 2 includes an OCT imaging light source 21 and an interferometer assembly 22, which are used to provide an imaging beam. Specifically, the imaging beam emitted by the OCT imaging light source 21 and the ablation beam emitted by the ablation device 1 respectively pass through the interferometer assembly 22 and the beam transmission optical path 13, and then enter the coupling device 3. Under the action of the dichroic mirror in the coupling device 3, the imaging beam and the ablation beam are combined and focused into the optical fiber 116 of the ablation catheter 11.

[0057] The control device 4 may include one or more of an acquisition card, a high-performance computer, a display screen, an integrated component, etc., and mainly realizes the functions of OCT image acquisition, processing, analysis, display, etc., and issues control commands to the driving device 5, the calibration device 6, the imaging device 2, and the ablation device 1 to enable their normal operation, and receives their feedback signals.

[0058] The driving device 5 may include a signal generator, a voltage amplifier, or other devices capable of realizing signal generation and amplification functions, which is connected to the conductive cable 117 of the ablation catheter 11 to provide the actuator 112 with the voltage amplitude and waveform required for operation.

[0059] The calibration device 6 may adopt a position sensor, or other devices that can realize the function of collecting the position coordinates of the light beam. The setting of the calibration device 6 can collect in advance the scanning trajectory coordinates of the light beam emitted by the ablation catheter 11 within one cycle, and provide them to the control device 4 to assist in image calibration, thereby avoiding the use of only the theoretically calculated scanning trajectory of the ablation catheter 11 for image reconstruction, and then achieving the effect of eliminating image distortion.

[0060] See also Figure 3 As shown, the present invention also provides a method for using an ablation system. The ablation system 100 can execute the method for using the ablation system to complete ablation of lesions at the lesion location in the region of interest.

[0061] Specifically, the method for using the ablation system includes the following steps:

[0062] S1, controlling the operation of the imaging device 2, the imaging device 2 acquires a real-time image of the region of interest through the optical fiber 116, and guides the ablation catheter 11 to move to the region of interest;

[0063] S2. Positioning and identifying the lesion position of the region of interest based on the real-time image, and adjusting the working position of the ablation catheter 11 so that the working position overlaps with the lesion position;

[0064] S3, controlling the ablation device 1 to perform ablation work, so that the ablation beam and / or imaging beam acts on the lesion position through the optical fiber 116, and ablating and / or imaging the lesion at the lesion position. .

[0065] In a preferred embodiment of the present disclosure, S0 is also included before S1. Specifically, S0 is: under a preset voltage, the actuator 112 in the ablation catheter 11 is controlled to drive the optical fiber cantilever 113 in the ablation catheter 11 to perform a scanning motion, and the ablation catheter 11 is moved to face the calibration device 6 to complete the calibration of the ablation device 1.

[0066] The following description will provide a detailed description of S0 to S3 of the method for using the ablation system.

[0067] In S0, the calibration of the ablation device 1 is specifically that the actuator 112 drives the optical fiber cantilever 113 to perform a scanning motion under the control of a preset voltage. The scanning trajectory can be spiral. The ablation catheter 11 is moved to face the position sensor in the calibration device 6. The position sensor collects the scanning trajectory coordinates of the light beam at the head end of the ablation catheter 11 for one period and provides them to the control device 4 for image calibration.

[0068] As mentioned above, the calibration device 6 includes a position sensor, which can collect the scanning trajectory coordinates of the light beam emitted from the front end of the ablation catheter 11 within a movement cycle, and calibrate the ablation device 1 through image calibration.

[0069] S1 specifically guides the ablation device 1 to move to the region of interest based on the image of the region of interest captured by the imaging device 2; the imaging beam is emitted through the head end of the ablation catheter 11, and the interference signal returned from the region is received, and the control device 4 captures the interference signal and processes it in real time to obtain a forward real-time three-dimensional OCT image of the region. Specifically, when the imaging device 2 is capturing the image of the region of interest, the driving device 5 drives the actuator 112 to drive the optical fiber cantilever 113 to perform a scanning motion, so that the imaging beam realizes the imaging of the region of interest from point to surface. At the same time, when the actuator 112 drives the optical fiber cantilever 113 to move for imaging, the control voltage of the actuator 112 is consistent with the voltage when the ablation device 1 is calibrated to ensure the accuracy of the imaging; of course, the control voltage of the actuator 112 during imaging may also be different from the voltage when the ablation device 1 is calibrated.

[0070] S2 specifically analyzes the real-time image features. If the image field of view deviates from the lesion and is a normal blood vessel wall, the ablation catheter 11 is adjusted to face the lesion according to the image guidance, and the lesion type is analyzed. Specifically, the real-time image is a real-time three-dimensional OCT image of the ablation device 1 moving forward and upward, which is obtained by the imaging device 2 through the ablation device 1. By performing image feature analysis on the real-time three-dimensional OCT image, it is determined whether the ablation device 1 deviates from the lesion position during the movement, and the ablation device 1 is guided and adjusted to face the lesion position, and the lesion type at the lesion position is analyzed.

[0071] S3 specifically controls the ablation device 1 to perform ablation, including:

[0072] The energy of the ablation beam emitted by the ablation device 1 is adjusted according to the type of lesion; when the regional properties of the region of interest where the ablation device 1 is located are identified according to the real-time image, the operating state of the imaging device 2 is adjusted based on the regional properties.

[0073] Specifically, when the regional properties are complex, the imaging device 2 is controlled to run in real time. The imaging device 2 obtains a real-time image of the region of interest through the ablation device 1 (specifically, the ablation catheter 11), and adjusts the direction of the ablation device 1 based on the real-time image; specifically, when the regional properties are complex, the blood vessels at the location of the region of interest are twisted, angled, and other complex situations. The simultaneous operation of the imaging device 2 can be monitored in real time. When the lesion in the image field of view is completely ablated and is about to damage the blood vessel wall, the direction of the ablation catheter 11 is adjusted in time according to the image information.

[0074] When the regional property is simple, the imaging device is controlled to obtain a real-time image of the region of interest after the ablation device 1 ablates for a preset time or after the ablation is completed, and the ablation effect is evaluated; specifically, when the regional property is simple, the region of interest is in a relatively straight blood vessel segment, or only the lesion is seen in the image field but not the blood vessel wall, the imaging device 2 may not be operated at the same time, and the ablation effect evaluation may be performed after ablation for a period of time.

[0075] That is, in the present disclosure, when the ablation device 1 is working, the working state of the imaging device 2 can be switched automatically according to actual needs.

[0076] Similarly, when the control device 4 controls the ablation device 1 to perform ablation, the control device 4 also controls the driving device 5 to drive the actuator 112 to drive the optical fiber cantilever 113 to perform a scanning motion, so that the ablation beam acts on the lesion position of the area of ​​interest from point to surface, thereby ensuring the integrity of the lesion ablation. In a preferred embodiment of the present disclosure, when the actuator 112 drives the optical fiber cantilever 113 to move to perform ablation, the control voltage of the actuator 112 is consistent with the voltage when the ablation device 1 is calibrated to ensure that the ablation beam can accurately act on the lesion position; of course, in other embodiments of the present disclosure, the control voltage of the actuator 112 may also be different from the voltage when the ablation device 1 is calibrated.

[0077] Furthermore, when the ablation device 1 and the imaging device 2 work simultaneously, since the ablation device 1 and the imaging device 2 are arranged in a common optical path, the coupling device 3 combines the ablation beam and / or the imaging beam, and the actuator 112 drives the optical fiber cantilever 113 to perform a scanning motion, so that the imaging beam and the ablation beam act on the lesion position in the area of ​​interest from point to surface, while ensuring the accuracy of imaging and the integrity of lesion ablation. Similarly, in this process, the control voltage when the actuator 112 controls the movement of the optical fiber cantilever 113 can be consistent with or different from the voltage when the ablation device 1 is calibrated.

[0078] In addition, it should be noted that the present disclosure only uses the ablation system 100 / the method of using the ablation system for intravascular plaque ablation as an example for illustration. Of course, in other embodiments of the present disclosure, the ablation system 100 / the method of using the ablation system can also be used in other fields, such as guiding the removal of tumors or cancer cells, guiding the removal of bone spurs or bone cutting, or other ablation applications suitable for OCT imaging guidance.

[0079] Furthermore, the description of the present disclosure only uses the imaging device 2 as an OCT imaging device as an example for illustration, but the imaging device 2 can be completely changed to fluorescence imaging based on the same ablation device 1. Although it is not suitable for intravascular guidance for plaque ablation, it can be applicable to other ablation applications guided by fluorescence imaging, such as guiding the removal of tumors or cancer cells. Even, the imaging device of the present invention can be OCT-fluorescence two-in-one imaging.

[0080] In summary, the ablation system 100 of the present invention sets the ablation device 1 and the imaging device 2 in the same optical path, and guides the ablation device 1 to move to the lesion position of the region of interest in real time through the imaging device 2; at the same time, when the ablation device 1 is used to ablate the lesion, the ablation situation of the lesion position can also be monitored by the imaging device 2, so that the ablation system 100 is highly integrated and convenient for the application of the ablation system. At the same time, by controlling the calibration of the ablation device 1 through the calibration device 6 before the ablation begins, the accuracy of the imaging of the imaging device 2 can be guaranteed, and then it is convenient to accurately judge the regional properties of the region of interest or the lesion properties of the lesion in the region of interest through the image captured by the imaging device 2; further, by controlling the coordination relationship between the imaging device 2 and the ablation device 1, the image of the working area can be obtained in real time through the imaging device 2, which is convenient for the ablation device 1 to complete the ablation; at the same time, the ablation effect can also be evaluated through the imaging device 2 after the ablation is completed, so as to ensure the safety and completeness of the ablation.

[0081] The above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solution of the present invention.

Claims

1. A method for using an ablation system, characterized in that: The ablation system comprises an ablation device, an imaging device, and a coupling device for coupling an imaging beam of the imaging device into an optical fiber of an ablation catheter of the ablation device; the method for using the ablation system comprises the following steps: S1, controlling the operation of an imaging device, wherein the imaging device acquires a real-time image of the region of interest through the optical fiber, and guides the ablation catheter to move to the region of interest; S2. Positioning and identifying the lesion position of the region of interest according to the real-time image, and adjusting the working position of the ablation catheter so that the working position overlaps with the lesion position; S3. Control the ablation device to perform ablation, so that the ablation beam and / or the imaging beam acts on the lesion location through the optical fiber, and ablates and / or images the lesion at the lesion location.

2. The method for using the ablation system according to claim 1, characterized in that: The ablation catheter comprises a front rigid part and a rear flexible part, wherein the front rigid part comprises at least a housing, an actuator and an optical fiber cantilever; and the rear flexible part comprises an optical fiber, a conductive cable and a sheath.

3. The method for using the ablation system according to claim 2, characterized in that: The fiber optic cantilever is a part of the optical fiber, and the optical fiber passes through the actuator to extend on one side of the actuator to form the fiber optic cantilever; so that one end of the fiber optic cantilever is fixed on the actuator and the other end extends away from the actuator.

4. The method for using the ablation system according to claim 1, characterized in that: Before S1, the method for using the ablation system also includes S0, which is: under a preset voltage, controlling the actuator in the ablation catheter to drive the optical fiber cantilever in the ablation catheter to perform a scanning motion, moving the ablation catheter to face the calibration device, and completing the calibration of the ablation device.

5. The method for using the ablation system according to claim 4, characterized in that: The calibration device includes a position sensor, which can collect the scanning trajectory coordinates of the light beam emitted from the front end of the ablation catheter within a movement cycle, and realize the calibration of the ablation device through image calibration.

6. The method for using the ablation system according to claim 1, characterized in that: The S2 also includes: performing image feature analysis on the real-time image to determine whether the ablation device deviates from the lesion position during movement, guiding and adjusting the ablation catheter to move to face the lesion position, and analyzing the lesion type at the lesion position based on the real-time image.

7. The method for using the ablation system according to claim 1, characterized in that: In S3, controlling the ablation device to perform ablation work includes: The energy of the ablation beam emitted by the ablation device is adjusted according to the lesion type at the lesion location; and the regional properties of the region of interest where the ablation catheter is located are identified according to the real-time image, and the operating state of the imaging device is adjusted based on the regional properties.

8. The method for using the ablation system according to claim 7, characterized in that: When the regional property is complex, the imaging device is controlled to operate in real time, the imaging device acquires the real-time image of the region of interest through the ablation catheter in real time, and adjusts the orientation of the ablation catheter based on the real-time image; When the regional property is a simple property, the imaging device is controlled to obtain the real-time image of the region of interest after the ablation device ablates for a preset time or after ablation is completed, so as to evaluate the ablation effect.

9. An ablation system, used to execute the method for using the ablation system according to any one of claims 1 to 8, characterized in that: The ablation system comprises: The ablation device comprises an ablation catheter, an ablation light source and a light beam transmission path; the ablation light source provides an ablation light beam and transmits it to the ablation catheter through the light beam transmission path to complete lesion ablation; An imaging device, including an OCT imaging light source and an interferometer assembly, for providing an imaging beam; A coupling device, used to combine the imaging light beam of the imaging device and the ablation light beam of the ablation device, and couple them into the optical fiber in the ablation catheter; A driving device, used for generating a voltage signal, and applying the voltage signal to the actuator in the ablation catheter through a conductive cable, and driving the actuator to generate displacement; The control device is used to control the operation of the imaging device and the ablation device, so as to obtain an image of the region of interest through the imaging device, and to complete the ablation of the lesion at the lesion position through the ablation device.

10. The ablation system according to claim 9, characterized in that: The ablation system further comprises a calibration device; the calibration device is used to collect the coordinates of the front-end light beam scanning trajectory of the ablation catheter for calibrating image distortion.

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