Composition for whitening face skin and preparation method thereof

Abstract

The invention discloses a face skin whitening composition and a preparation method thereof, and relates to the technical field of cosmetics, the face skin whitening composition comprises 1-8 parts of an arbutin extract, 1-6 parts of vitamin C magnesium phosphate, 0.5-5 parts of dipotassium glycyrrhizinate, 0.1-3 parts of sodium hyaluronate, and 1-10 parts of a ginkgo leaf extract. According to the composition for whitening the human face skin and the preparation method of the composition, the arbutin extract can inhibit the activity of tyrosinase and reduce the generation of melanin; the vitamin C magnesium phosphate has an anti-oxidation effect and can be used for reducing melanin and fading color spots; the dipotassium glycyrrhizinate, the sodium hyaluronate and the ginkgo biloba extract are matched with one another, so that not only can the skin blood circulation be improved and the skin metabolism be promoted, but also the effects of resisting inflammation and relieving the skin are achieved, in addition, permeation and function exertion of whitening components are facilitated, and the whitening effect is enhanced.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a composition for whitening human facial skin and a preparation method thereof. Background Art

[0002] There are many whitening products on the market today, but some products have problems such as insignificant effects, irritating ingredients, and poor stability.

[0003] Therefore, there is a need for a composition that has low irritation to the skin, can inhibit the production of melanin, improve skin blood circulation, and accelerate cell metabolism to improve the deficiencies of the prior art. Summary of the invention

[0004] The main purpose of the present invention is to provide a composition for whitening human facial skin and a preparation method thereof, which can effectively solve the problems in the background technology.

[0005] To achieve the above object, the technical solution adopted by the present invention is: A composition for whitening human facial skin comprises, by weight, 1-8 parts of arbutin extract, 1-6 parts of magnesium vitamin C phosphate, 0.5-5 parts of dipotassium glycyrrhizinate, 0.1-3 parts of sodium hyaluronate, and 1-10 parts of ginkgo leaf extract.

[0006] Preferably, the facial skin whitening composition comprises, by weight: 2-6 parts of arbutin extract, 2-5 parts of magnesium vitamin C phosphate, 1-4 parts of dipotassium glycyrrhizinate, 0.5-2 parts of sodium hyaluronate, and 3-8 parts of ginkgo leaf extract.

[0007] Preferably, the facial skin whitening composition comprises, by weight: 4 parts of arbutin extract, 3 parts of magnesium ascorbyl phosphate, 2 parts of dipotassium glycyrrhizinate, 1 part of sodium hyaluronate, and 5 parts of ginkgo leaf extract.

[0008] A method for preparing the above-mentioned facial skin whitening composition, the specific steps are as follows: Step 1: Wash and dry the ginkgo leaves, grind them into fine powder (particle size 1-2 mm) in a grinder, put them into a container, add ethanol solution (volume fraction 70%-80%) 3-5 times the mass of the powder into the container, ultrasonically extract at 35-40℃ for 4-6h, filter, separate the solid and liquid, and obtain the primary filter residue and primary filtrate for use; Step 2: put the primary filter residue into a container, add an ethanol solution (volume fraction of 70%-80%) of 2-4 times the mass of the primary filter residue into the container, heat and keep the temperature at 35°C-40°C, seal the container, control the stirring speed at 100-150r / min, soak and extract for 18-24h, filter under 8-10Mpa, separate the solid and liquid, obtain a secondary filtrate for standby use, combine the secondary filtrate with the primary filtrate, remove the ethanol by vacuum distillation, obtain a concentrated solution, freeze-dry the concentrated solution into powder, and obtain a ginkgo leaf extract; Step 3: placing the glucose raw material in a reactor, protecting the glucose hydroxyl group by acetylation, performing a bromination reaction on the protected glucose to obtain α-bromotetraacetyl glucose, performing a condensation reaction on the α-bromotetraacetyl glucose and hydroquinone under alkaline conditions, and performing a hydrolysis reaction on the condensation reaction product to obtain pure arbutin; Step 4: adding vitamin C, anhydrous calcium chloride and deionized water to a reactor, stirring and adjusting the pH value, then adding sodium hydroxide aqueous solution and sodium trimetaphosphate to carry out esterification reaction to obtain vitamin C ester calcium, washing the vitamin C ester calcium with water, adjusting the pH value to obtain vitamin C phosphate, filtering the vitamin C phosphate through a nanofiltration membrane filter, adding the filtered filtrate to a reactor, treating it through a weakly alkaline anion exchange resin, eluting it with hydrochloric acid, collecting the eluted portion, and adjusting the pH value with magnesium oxide to obtain vitamin C phosphate magnesium; Step 5: stirring and dissolving ethanol and glycyrrhizic acid, and then mixing with a potassium hydroxide aqueous solution, filtering and drying to obtain dipotassium glycyrrhizinate; Step 6: Under specific temperature and pH conditions, hyaluronic acid is produced through the metabolism of microorganisms, and sodium hyaluronate is obtained through separation, purification and crystallization steps; Step 7: accurately weigh arbutin, magnesium vitamin C phosphate, dipotassium glycyrrhizinate, sodium hyaluronate, and ginkgo leaf extract according to the ratio, put them into a container, add 8 times the volume of deionized water, and mix well to obtain the composition for whitening human facial skin.

[0009] Preferably, in step 4, after washing the calcium vitamin C ester with water, the pH value is adjusted to be in the range of 1.5-3.5 to obtain vitamin C phosphate.

[0010] Preferably, in step 6, the microorganisms used include but are not limited to Streptococcus and Bacillus plantarum.

[0011] Preferably, in step 6, the fermentation temperature is 25°C-40°C, and the fermentation pH value is between 6.5-8.5.

[0012] Compared with the prior art, the present invention has the following beneficial effects: The present invention can inhibit the activity of tyrosinase and reduce the generation of melanin through arbutin extract; magnesium ascorbyl phosphate has an antioxidant effect and can reduce melanin; dipotassium glycyrrhizinate, sodium hyaluronate and ginkgo leaf extract cooperate with each other to improve skin blood circulation, promote skin metabolism, have anti-inflammatory and skin soothing effects, and also help the penetration and action of whitening ingredients to enhance the whitening effect. DETAILED DESCRIPTION

[0013] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0014] Example 1 Step 1: Wash and dry the ginkgo leaves, grind them into fine powder (particle size 1.5 mm) in a grinder, put them into a container, add ethanol solution (volume fraction 76%) 4 times the mass of the powder into the container, ultrasonically extract at 38°C for 5 hours, filter, separate the solid and liquid, and obtain the primary residue and primary filtrate for use; Step 2: put the primary filter residue into a container, add ethanol solution (volume fraction of 76%) 3 times the mass of the primary filter residue into the container, heat and keep the temperature at 38°C, seal the container, control the stirring speed at 120r / min, soak and extract for 20h, filter under 9Mpa, separate the solid and liquid, obtain the secondary filtrate for standby use, combine the secondary filtrate with the primary filtrate, remove the ethanol by vacuum distillation, obtain the concentrated solution, freeze-dry the concentrated solution into powder, and obtain the ginkgo leaf extract; Step 3: placing the glucose raw material in a reactor, protecting the glucose hydroxyl group by acetylation, performing a bromination reaction on the protected glucose to obtain α-bromotetraacetyl glucose, performing a condensation reaction on the α-bromotetraacetyl glucose and hydroquinone under alkaline conditions, and performing a hydrolysis reaction on the condensation reaction product to obtain pure arbutin; Step 4: adding vitamin C, anhydrous calcium chloride and deionized water to a reactor, stirring and adjusting the pH value, then adding sodium hydroxide aqueous solution and sodium trimetaphosphate to carry out esterification reaction to obtain vitamin C ester calcium, washing the vitamin C ester calcium with water, adjusting the pH value to 2, obtaining vitamin C phosphate, filtering the vitamin C phosphate through a nanofiltration membrane filter, adding the filtered filtrate to a reactor, treating it through a weakly alkaline anion exchange resin, eluting it with hydrochloric acid, collecting the eluted portion, and adjusting the pH value with magnesium oxide to obtain vitamin C phosphate magnesium; Step 5: stirring and dissolving ethanol and glycyrrhizic acid, and then mixing with a potassium hydroxide aqueous solution, filtering, drying, and other processes to obtain dipotassium glycyrrhizinate; Step 6: Under the conditions of a temperature of 34°C and a pH value of 7, hyaluronic acid is produced through the metabolism of microorganisms (such as streptococci, plant bacillus, etc.), and sodium hyaluronate is obtained through separation, purification and crystallization steps; Step 7: Accurately weigh 4 parts of arbutin extract, 3 parts of magnesium vitamin C phosphate, 2 parts of dipotassium glycyrrhizinate, 1 part of sodium hyaluronate, and 5 parts of ginkgo leaf extract according to the ratio and put them into a container, add 8 times the volume of deionized water, and mix evenly to obtain the composition for whitening human facial skin.

[0015] The composition prepared in this example is in the form of an emulsion, and has a pH value of 6.4.

[0016] Example 2 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 3 parts of arbutin extract, 2 parts of magnesium ascorbyl phosphate, 1.5 parts of dipotassium glycyrrhizinate, 0.8 parts of sodium hyaluronate, and 4 parts of ginkgo leaf extract.

[0017] Example 3 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 5 parts of arbutin extract, 4 parts of magnesium ascorbyl phosphate, 3 parts of dipotassium glycyrrhizinate, 1.5 parts of sodium hyaluronate, and 6 parts of ginkgo leaf extract.

[0018] Example 4 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 2 parts of arbutin extract, 2 parts of magnesium ascorbyl phosphate, 1 part of dipotassium glycyrrhizinate, 0.5 parts of sodium hyaluronate, and 3 parts of ginkgo leaf extract.

[0019] Example 5 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 6 parts of arbutin extract, 5 parts of magnesium ascorbyl phosphate, 4 parts of dipotassium glycyrrhizinate, 2 parts of sodium hyaluronate, and 8 parts of ginkgo leaf extract.

[0020] Example 6 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 4 parts of arbutin extract, 3 parts of magnesium ascorbyl phosphate, 2 parts of dipotassium glycyrrhizinate, 1 part of sodium hyaluronate, 5 parts of ginkgo leaf extract, and 5 parts of ginkgo leaf extract are replaced with 5 parts of ginkgo fruit extract.

[0021] The preparation method of the ginkgo fruit extract is exactly the same as the preparation method of the ginkgo leaf extract in Example 1.

[0022] Example 7 In this embodiment, the content of each extract is adjusted on the basis of the embodiment 1, as follows: 3 parts of magnesium ascorbyl phosphate, 2 parts of dipotassium glycyrrhizinate, 1 part of sodium hyaluronate, 5 parts of ginkgo leaf extract. In this embodiment, arbutin extract is not added.

[0023] Comparative Example 1 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: In this comparative example, the content of each extract is adjusted on the basis of Example 1, specifically as follows: 8 parts of arbutin extract, 6 parts of magnesium ascorbyl phosphate, 5 parts of dipotassium glycyrrhizinate, 3 parts of sodium hyaluronate, and 10 parts of ginkgo leaf extract.

[0024] Comparative Example 2 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 1 part of arbutin extract, 1 part of magnesium vitamin C phosphate, 0.5 part of dipotassium glycyrrhizinate, 0.1 part of sodium hyaluronate, 1 part of ginkgo leaf extract.

[0025] Comparative Example 3 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 2 parts of dipotassium glycyrrhizinate, 1 part of sodium hyaluronate, 5 parts of ginkgo leaf extract. Arbutin extract and magnesium vitamin C phosphate are not added in this comparative example.

[0026] Comparative Example 4 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 4 parts of arbutin extract, 3 parts of magnesium ascorbyl phosphate, 1 part of sodium hyaluronate, 5 parts of ginkgo leaf extract. No dipotassium glycyrrhizinate is added in this comparative example.

[0027] Comparative Example 5 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 4 parts of arbutin extract, 3 parts of magnesium ascorbyl phosphate, 2 parts of dipotassium glycyrrhizinate, 5 parts of ginkgo leaf extract. Sodium hyaluronate is not added in this comparative example.

[0028] Comparative Example 6 In this comparative example, the content of each extract is adjusted on the basis of Example 1, as follows: 4 parts of arbutin extract, 3 parts of magnesium ascorbyl phosphate, 2 parts of dipotassium glycyrrhizinate, and 1 part of sodium hyaluronate. No ginkgo leaf extract is added in this comparative example.

[0029] Comparative Example 7 This comparative example uses 4 portions of arbutin extract alone.

[0030] Comparative Example 8 This comparative example uses 3 parts of magnesium ascorbyl phosphate alone.

[0031] Comparative Example 9 This comparative example uses 2 parts of dipotassium glycyrrhizinate alone.

[0032] Comparative Example 10 This comparative example uses 1 part of sodium hyaluronate alone.

[0033] Comparative Example 11 This comparative example uses 5 parts of Ginkgo biloba leaf extract alone.

[0034] The stability test was conducted on the facial skin whitening compositions in Examples 1-7 and Comparative Examples 1-11. Each composition was placed in a 40°C thermostat and a -10°C refrigerator for 3 months. During the storage process, the changes in appearance, odor, and pH value were observed, and the change results were recorded in detail, as shown in the following table: The results showed that the compositions in Examples 1-7 had good stability, with little change in appearance, odor, and pH value, while the compositions in Comparative Examples 1-11 showed varying degrees of precipitation, discoloration, pH value fluctuation, and other instability during storage.

[0035] The whitening effect of the facial skin whitening composition in Examples 1-7 and Comparative Examples 1-11 was tested. 30 female volunteers aged between 25 and 45 with facial spots were selected. The face was divided equally into left and right sides. The test sample was used on the left side and the placebo was used on the right side. The skin was used once in the morning and evening for 8 consecutive weeks. A professional skin detector was used to detect the melanin content, spot area and brightness changes of the skin before and after use, and the statistical results were summarized. Each link was strictly controlled to accurately quantify the whitening performance of the composition from multiple dimensions, providing a solid basis for evaluation. The specific test results are shown in the following table: The results show that the compositions in Examples 1-7 all have obvious whitening effects, with reduced melanin content, smaller spot area, and improved skin brightness. Among them, the composition with the proportion of each component in Example 1 has the best whitening effect, while the compositions in Comparative Examples 1-11 have no obvious or no whitening effect.

[0036] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A composition for whitening facial skin, characterized in that: The composition comprises, by weight, 1-8 parts of arbutin extract, 1-6 parts of magnesium vitamin C phosphate, 0.5-5 parts of dipotassium glycyrrhizinate, 0.1-3 parts of sodium hyaluronate and 1-10 parts of ginkgo leaf extract.

2. A facial skin whitening composition according to claim 1, characterized in that: The facial skin whitening composition comprises, by weight: 2-6 parts of arbutin extract, 2-5 parts of magnesium vitamin C phosphate, 1-4 parts of dipotassium glycyrrhizinate, 0.5-2 parts of sodium hyaluronate, and 3-8 parts of ginkgo leaf extract.

3. A facial skin whitening composition according to claim 1, characterized in that: The facial skin whitening composition comprises, by weight: 4 parts of arbutin extract, 3 parts of magnesium vitamin C phosphate, 2 parts of dipotassium glycyrrhizinate, 1 part of sodium hyaluronate, and 5 parts of ginkgo leaf extract.

4. A method for preparing the facial skin whitening composition according to any one of claims 1 to 3, characterized in that: The specific steps are as follows: Step 1: Wash and dry the ginkgo leaves, grind them into fine powder (particle size 1-2 mm) in a grinder, put them into a container, add ethanol solution (volume fraction 70%-80%) 3-5 times the mass of the powder into the container, ultrasonically extract at 35-40℃ for 4-6h, filter, separate the solid and liquid, and obtain the primary filter residue and primary filtrate for use; Step 2: put the primary filter residue into a container, add an ethanol solution (volume fraction of 70%-80%) of 2-4 times the mass of the primary filter residue into the container, heat and keep the temperature at 35°C-40°C, seal the container, control the stirring speed at 100-150r / min, soak and extract for 18-24h, filter under 8-10Mpa, separate the solid and liquid, obtain a secondary filtrate for standby use, combine the secondary filtrate with the primary filtrate, remove the ethanol by vacuum distillation, obtain a concentrated solution, freeze-dry the concentrated solution into powder, and obtain a ginkgo leaf extract; Step 3: placing the glucose raw material in a reactor, protecting the glucose hydroxyl group by acetylation, performing a bromination reaction on the protected glucose to obtain α-bromotetraacetyl glucose, performing a condensation reaction on the α-bromotetraacetyl glucose and hydroquinone under alkaline conditions, and performing a hydrolysis reaction on the condensation reaction product to obtain pure arbutin; Step 4: adding vitamin C, anhydrous calcium chloride and deionized water to a reactor, stirring and adjusting the pH value, then adding sodium hydroxide aqueous solution and sodium trimetaphosphate to carry out esterification reaction to obtain vitamin C ester calcium, washing the vitamin C ester calcium with water, adjusting the pH value to obtain vitamin C phosphate, filtering the vitamin C phosphate through a nanofiltration membrane filter, adding the filtered filtrate to a reactor, treating it through a weakly alkaline anion exchange resin, eluting it with hydrochloric acid, collecting the eluted portion, and adjusting the pH value with magnesium oxide to obtain vitamin C phosphate magnesium; Step 5: stirring and dissolving ethanol and glycyrrhizic acid, and then mixing with a potassium hydroxide aqueous solution, filtering and drying to obtain dipotassium glycyrrhizinate; Step 6: Under specific temperature and pH conditions, hyaluronic acid is produced through the metabolism of microorganisms, and sodium hyaluronate is obtained through separation, purification and crystallization steps; Step 7: accurately weigh arbutin, magnesium vitamin C phosphate, dipotassium glycyrrhizinate, sodium hyaluronate, and ginkgo leaf extract according to the ratio, put them into a container, add 8 times the volume of deionized water, and mix well to obtain the composition for whitening human facial skin.

5. The method for preparing a facial skin whitening composition according to claim 4, characterized in that: In the step 4, after washing the calcium vitamin C ester with water, the pH value is adjusted to be in the range of 1.5-3.5 to obtain vitamin C phosphate.

6. The method for preparing a facial skin whitening composition according to claim 5, characterized in that: In step 6, the microorganisms used include but are not limited to Streptococcus and Plant Bacillus.

7. The method for preparing a facial skin whitening composition according to claim 4, characterized in that: In step 6, the fermentation temperature is 25° C.-40° C., and the fermentation pH value is between 6.5-8.5.

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