Cosmetic nano-emulsion prepared based on common homogenizer and method
By changing the emulsifier and oil types in an ordinary homogenizer, cosmetic nanoemulsions with nanoparticle size were successfully prepared, which solved the problem that ordinary homogenizer could not prepare nanoemulsions, and achieved the preparation of nanoemulsions with low energy consumption and simple process.
Patent Information
- Application Number
- CN202411936062.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-26
- Publication Date
- 2025-04-11
AI Technical Summary
In the prior art, the energy output and shear force of ordinary homogenizers are too low to be used to prepare nanoemulsions, limiting the application range of low-energy emulsion methods.
By changing the types of emulsifiers and fats, emulsifying them using a normal homogenizer, cosmetic nanoemulsions with nanoparticle sizes were prepared.
The use of ordinary homogeneous mechanism for preparing nanoemulsions in low-energy emulsion is realized, which has the advantages of simple process and low energy consumption, and shows obvious micro-blue emulsion phenomenon (Tindal phenomenon).
Smart Images
Figure CN119792135A_ABST
Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a cosmetic nanoemulsion and a method for preparing the same based on a common homogenizer. Background Art
[0002] An emulsion is a colloidal chemical dispersion system in which one liquid is uniformly dispersed in another immiscible liquid by adding an emulsifier. The droplet size distribution of the emulsion determines the properties of the emulsion, such as long-term stability, texture and optical appearance. So far, the theory of surfactant-stabilized emulsions has been greatly developed. A special emulsion, nanoemulsion, has attracted people's attention because of its significantly superior physical and chemical properties.
[0003] Nanoemulsion is between microemulsion and ordinary emulsion, also known as fine emulsion or microemulsion, and is an emulsion with a particle size in the nanometer range. Compared with ordinary emulsion, nanoemulsion has a larger specific surface area and free energy, making this type of emulsion an effective delivery system. As a skin care delivery medium in cosmetics, nanoemulsion is attracting more and more attention because of its ability to effectively disperse active ingredients and promote penetration. The main advantages of nanoemulsion in cosmetics are as follows: It promotes the penetration of active ingredients; its emulsion system has good stability and is not prone to stratification, flocculation, accumulation and precipitation; nanoemulsion with appropriate particle size will not damage healthy skin and cells, so it can be used in therapeutic products.
[0004] When preparing emulsions, the following factors need to be considered: emulsification process, conditions, type of ingredients (surfactant, oil phase and aqueous phase) and the amount of these in the system. For the preparation of nanoemulsions, there are two approaches: high energy methods using mechanical devices and low energy methods using the chemical potential of the components. High energy methods involve high shear stirring using rotor / stator systems, using ultrasound, high pressure homogenizers, and especially microfluidization and membrane emulsification. Low energy methods include phase inversion temperature (PIT), phase inversion composition (PIC) and solvent diffusion (or self-emulsification or even spontaneous emulsification in non-equilibrium state) methods. In the field of cosmetics, O / W nanoemulsion type has been studied more than W / O type, and high energy methods are the most reported methods in recent literature, although there has been considerable development in the recent research on low energy methods. Although it is often complex, it has the advantage of energy saving and is a less destructive process for unstable bioactive molecules.
[0005] The study also showed that both types of methods (high energy and low energy methods) can achieve similar droplet sizes depending on the system and composition variables. Currently, there is no process for making nanoemulsions using ordinary homogenizers in low energy emulsification methods, mainly because the energy output and shear force of ordinary homogenizers are too low to form ordinary emulsions, but not nanoemulsions. Therefore, it is basically not considered in the low energy emulsification method. This application realizes the use of ordinary homogenizers to make nanoemulsions in low energy emulsification methods by changing the types of emulsifiers and oils, so as to achieve the advantages of simple process and low energy consumption. Summary of the invention
[0006] In view of the problems existing in the prior art, the purpose of the present invention is to provide a cosmetic nanoemulsion and method prepared based on a common homogenizer, which is specifically achieved through the following technical solutions: A cosmetic nanoemulsion prepared by a common homogenizer, the nanoemulsion consists of an aqueous phase and an oil phase, the aqueous phase comprises water, glycerin and butylene glycol; the oil phase consists of an emulsifier and oil, the emulsifier is polyglycerol-10 distearate, and the oil is a mixture of one or more of hydrogenated polyisobutene, isohexadecane, isododecane or squalane.
[0007] Furthermore, the mass percentages of the various components of the nanoemulsion are: Water 80.00-91.75%, glycerin 4.00-5.00%, butylene glycol 2.00-3.00%, emulsifier 0.25-4%; oil 2-8%.
[0008] Furthermore, the mass percentages of the various components of the nanoemulsion are: Water 87%, glycerin 5%, butylene glycol 3%, emulsifier 1%; oil 4%.
[0009] A method for preparing a cosmetic nanoemulsion comprises the following steps: 1) Take the formulated amount of water, glycerin and butanediol, add them into a beaker, stir them evenly with a blender, and heat them in a water bath to 75-85°C to obtain the water phase; 2) Take the formula amount of emulsifier and oil in a beaker, mix them and place them in a water bath to heat until the emulsifier is completely dissolved in the oil. During this period, use a glass rod to halve the mixture to obtain the oil phase; 3) homogenizing the water phase obtained in step 1) in a common homogenizer, and at the same time slowly pouring the oil phase obtained in step 2) into the water phase, and homogenizing for 3-4 minutes to obtain a nanoemulsion; 4) The nanoemulsion prepared in step 3) is stirred in a mixer in a cold water bath and cooled to 35°C.
[0010] Furthermore, in step 1), the rotation speed of the stirrer is 200-500 rpm.
[0011] Furthermore, in step 2), the heating temperature of the water bath is 75-85°C.
[0012] Furthermore, in step 3), the rotation speed of the common homogenizer is 4000-5000 rpm, and the rotation speed of the mixer in step 4) is 200-500 rpm.
[0013] The present invention adopts a common homogenizer that is basically not considered within the scope of the low-energy emulsification method to disperse and achieve the emulsion nano effect. Compared with the existing nanoemulsion preparation process, the present invention has the advantages of low energy and simple process, and the prepared product has obvious micro-blue opalescence phenomenon (Tyndall phenomenon). BRIEF DESCRIPTION OF THE DRAWINGS
[0014] Figure 1 This is an observation diagram of the product obtained in Example 1; Figure 2 Observation diagram of the products obtained in Example 2 and Comparative Examples 1-3; Figure 3 This is an observation diagram of the product obtained in Comparative Example 4-5. DETAILED DESCRIPTION
[0015] The present invention is further described below in conjunction with specific embodiments to facilitate a better understanding of the present technical solution. Example 1
[0016] Step 1: Prepare the aqueous phase 87% water, 5% glycerol and 3% butanediol are added into a beaker according to mass percentage, stirred evenly with a stirrer at 200-500 rpm, and then placed in a water bath and heated to 75-85° C. to obtain a water phase.
[0017] Step 2: Preparation of oil phase Take 1% polyglyceryl-10 distearate and hydrogenated polyisobutylene, 2% isohexadecane, and 2% isododecane or squalane and mix them in a beaker. Heat the beaker in a water bath to 75-85°C and stir evenly with a glass rod. When polyglyceryl-10 distearate is observed to be dissolved in the oil, the oil phase is obtained.
[0018] Step 3: Mix well Place the water phase under a homogenizer at 4000-5000 rpm, slowly pour the oil phase in and homogenize for 3-4 minutes to obtain a nanoemulsion.
[0019] Step 4: Cool down.
[0020] The nanoemulsion prepared in step 3 was cooled to 35° C. by stirring in a cold water bath at 200-500 rpm in a stirrer.
[0021] Example 1 Stability test method of the prepared nanoemulsion: According to the above preparation method, 3 bottles of 50g of nanoemulsion were placed in a biochemical incubator at -18℃, room temperature, and 45℃, respectively. They were taken out every month and returned to room temperature after 24 hours for observation. This was repeated 3 times. After three months, the experiment was observed with a black background because the white background could not be used to observe the experimental phenomenon well. We found that the slightly blue opalescence phenomenon still existed, such as Figure 1 shown. Example 2
[0022] The formula and preparation method of this embodiment are basically the same as those of Embodiment 1, except that the oil in this embodiment is hydrogenated polyisobutylene accounting for 4% of the total amount.
[0023] Comparative Example 1 The difference between this comparative example and Example 2 is that the oil is caprylic / capric triglyceride accounting for 4% of the total amount, and the rest is the same as Example 2.
[0024] Comparative Example 2 The difference between this comparative example and Example 2 is that the oil is selected as isononyl isononanoate accounting for 4% of the total amount, and the rest is the same as Example 2.
[0025] Comparative Example 3 The difference between this comparative example and Example 2 is that the grease is polydimethylsiloxane accounting for 4% of the total amount, and the rest is the same as Example 2.
[0026] The products obtained in Example 2 and Comparative Examples 1-3 were observed, and the results are shown in Figure 2 ,from Figure 2 It can be clearly observed that only the product prepared in Example 2 using the formulation of the present invention has a slightly blue opalescence phenomenon.
[0027] Comparative Example 4 The difference between this comparative example and Example 1 is that the emulsifier is 1% sucrose stearate, and the rest is the same as Example 1.
[0028] Comparative Example 5 The difference between this comparative example and Example 1 is that the emulsifier is 1% of polyglycerol-3 methyl glucose distearate, and the rest is the same as Example 1.
[0029] The products obtained in Example 4 and Example 5 were observed, and the results are shown in Figure 3 As shown, from Figure 3 It can be seen that when the type of emulsifier is changed, the product obtained cannot achieve the nanoemulsion with a slightly blue opalescent phenomenon.
Claims
1. A cosmetic nanoemulsion prepared by a common homogenizer, characterized in that: The nanoemulsion is composed of an aqueous phase and an oil phase, wherein the aqueous phase includes water, glycerol and butylene glycol; the oil phase is composed of an emulsifier and oil, wherein the emulsifier is polyglycerol-10 distearate, and the oil is a mixture of one or more of hydrogenated polyisobutene, isohexadecane, isododecane or squalane.
2. A cosmetic nanoemulsion prepared by a common homogenizer according to claim 1, characterized in that: The mass percentages of the various components of the nanoemulsion are: Water 80.00-91.75%, glycerin 4.00-5.00%, butylene glycol 2.00-3.00%, emulsifier 0.25-4%; oil 2-8%.
3. A cosmetic nanoemulsion prepared by a common homogenizer as described in claim 2, characterized in that: The mass percentages of the various components of the nanoemulsion are: Water 87%, glycerin 5%, butylene glycol 3%, emulsifier 1%; oil 4%.
4. A method for preparing a cosmetic nanoemulsion according to any one of claims 1 to 3, characterized in that The following steps are involved: 1) Take the formulated amount of water, glycerin and butanediol, add them into a beaker, stir them evenly with a blender, and heat them in a water bath to 75-85°C to obtain the water phase; 2) Take the formula amount of emulsifier and oil in a beaker, mix them and place them in a water bath to heat until the emulsifier is completely dissolved in the oil. During this period, use a glass rod to halve the mixture to obtain the oil phase; 3) homogenizing the water phase obtained in step 1) in a common homogenizer, and at the same time slowly pouring the oil phase obtained in step 2) into the water phase, and homogenizing for 3-4 minutes to obtain a nanoemulsion; 4) The nanoemulsion prepared in step 3) is stirred in a mixer in a cold water bath and cooled to 35°C.
5. The method for preparing a cosmetic nanoemulsion according to claim 4, characterized in that In step 1), the rotation speed of the stirrer is 200-500 rpm.
6. The method for preparing a cosmetic nanoemulsion according to claim 4, characterized in that In step 2), the water bath is heated to 75-85°C.
7. The method for preparing a cosmetic nanoemulsion according to claim 4, characterized in that In step 3), the rotation speed of the ordinary homogenizer is 4000-5000 rpm, and the rotation speed of the mixer in step 4) is 200-500 rpm.