Preparation process of antelope horn particles

Abstract

The invention discloses a preparation technology of antelope horn particles, and belongs to the technical field of traditional Chinese medicine preparation.The preparation technology of the antelope horn particles comprises the following steps that S1, raw material preparation is conducted, specifically, 8-15 g of antelope horn with the qualified quality is selected as a raw material, S2, decoction extraction is conducted, specifically, a proper amount of water is added into the antelope horn for first-time decoction, and after first-time decoction, decoction extraction is conducted; s3, hydrolysis treatment: adding 2-16 times of a sulfuric acid solution into decoction dregs obtained after decoction, and heating for hydrolysis until no brown particles appear in the solution, adding a proper amount of water for secondary decoction, and after the secondary decoction is completed, combining the decoctions obtained after the two times of decoction, and filtering to remove impurities to obtain a primary extracting solution for later use, and S3, hydrolysis treatment: adding 2-16 times of the sulfuric acid solution into the decoction dregs obtained after decoction, and heating for hydrolysis until no brown particles appear in the solution. According to the preparation process of the antelope horn particles, the extraction rate and the purity of effective components of antelope horns are effectively improved by accurately controlling the decoction time and hydrolysis treatment, meanwhile, the stability and the biological activity of products are guaranteed, impurities are effectively removed through multiple times of filtration and alcohol precipitation treatment, and the purity of the products is improved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparation, and in particular to a preparation process of antelope horn particles. Background Art

[0002] Antelope horn, a traditional Chinese medicine, has the effects of calming the liver and relieving wind, clearing the liver and improving eyesight, dispersing blood and detoxifying. It is often used for internal liver wind movement, convulsions, eclampsia during pregnancy, high fever convulsions, epilepsy, headache and dizziness, red eyes and cataracts, warm toxins and spots, carbuncles and sores. As a traditional Chinese medicine, antelope horn is widely used in clinical Chinese medicine.

[0003] The extraction and preparation process of the active ingredients of antelope horn directly affects its efficacy and the convenience of clinical application. The traditional decoction method often leads to incomplete extraction of active ingredients or excessive impurity content due to too long or insufficient decoction time, affecting the extraction efficiency and the quality of antelope horn particles. At the same time, the lack of filtration and purification steps makes it difficult to ensure the purity of antelope horn particles, thus affecting its pharmacological activity and safety. Summary of the invention

[0004] The invention aims to provide a preparation process of antelope horn particles. By precisely controlling the decoction time and hydrolysis treatment, the extraction rate and purity of the effective components of antelope horn are effectively improved, while ensuring the stability and biological activity of the product. Through multiple filtration and alcohol precipitation treatment, impurities are effectively removed and the purity of the product is improved.

[0005] In order to achieve the above effects, the present invention provides the following technical solution: a process for preparing antelope horn particles, comprising the following steps:

[0006] Step 1. Raw material preparation: Select 8-15g of qualified antelope horn as raw material.

[0007] Step 2, decoction extraction: add appropriate amount of water to the antelope horn for the first decoction. After the first decoction, add appropriate amount of water again for the second decoction. After the second decoction is completed, combine the decoctions after the two decoctions, filter to remove impurities, and obtain a preliminary extract for use.

[0008] Step 3, hydrolysis treatment: add 2-16 times the amount of sulfuric acid solution to the decocted medicinal residue, heat and hydrolyze until no brown particles appear in the solution, and obtain a hydrolyzate after the hydrolysis is completed. Filter the hydrolyzate to remove insoluble impurities, then adjust the pH value of the hydrolyzate to an appropriate range, filter it again, and combine the filtrate after pH adjustment with the preliminary extract to obtain a comprehensive extract.

[0009] Step 4: Concentration and alcohol precipitation: Concentrate the comprehensive extract to an appropriate volume, then add ethanol to it to make it reach a certain alcohol content, let it stand to allow impurities to precipitate, and then filter to remove the precipitate.

[0010] Step 5: Ethanol recovery and concentration: recover the ethanol in the filtrate and further concentrate the remaining liquid to a thick paste.

[0011] Step six, granulation and drying: add appropriate amount of auxiliary materials to the thick paste, mix evenly, and make granules through a granulator. After the granules are dried, the finished antelope horn granules are obtained, and the finished antelope horn granules are packaged.

[0012] Furthermore, the method comprises the following steps: according to the operation steps in step one, the antelope horn is selected from antelope horns that have been cleaned and crushed to a suitable fineness.

[0013] Further, the method comprises the following steps: according to the operation steps in step 2, the first decoction time is 2-6 hours, and the second decoction time is 2-5 hours.

[0014] Further, the method comprises the following steps: according to the operation steps in step three, the concentration of the sulfuric acid solution is 1-2 mol / L.

[0015] Further, the method comprises the following steps: according to the operation steps in step three, the pH value of the medicinal residue filtrate is adjusted using calcium hydroxide.

[0016] Further, the method comprises the following steps: according to the operation steps in step 4, the alcohol content is 75% to 85%.

[0017] Further, the method comprises the following steps: according to the operation steps in step 4, the static environment temperature is about 0°C.

[0018] Further, the method comprises the following steps: according to the operation steps in step five, the relative density of the thick paste is 1.05-1.20, and the temperature range of the thick paste when measuring the relative density is 50-60°C.

[0019] Further, the method comprises the following steps: according to the operation steps in step six, the auxiliary material is powdered sugar or dextrin.

[0020] Furthermore, the method comprises the following steps: according to the operating steps in step six, an aluminum foil composite film is selected as the packaging material for the finished antelope horn particles.

[0021] The present invention provides a process for preparing antelope horn particles, which has the following beneficial effects:

[0022] (1) The antelope horn granule preparation process effectively improves the extraction rate and purity of the effective ingredients in antelope horn by precisely controlling the decoction time and hydrolysis treatment, while ensuring the stability and biological activity of the product.

[0023] (2) The antelope horn granule preparation process effectively removes impurities and improves the purity of the product through multiple filtration and alcohol precipitation treatments. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the preparation process of the present invention. DETAILED DESCRIPTION

[0025] The present invention provides a technical solution: please refer to Figure 1 The process for preparing antelope horn particles comprises the following steps:

[0026] Step 1. Raw material preparation: Select 8-15g of qualified antelope horn as raw material.

[0027] Step 2, decoction extraction: add appropriate amount of water to the antelope horn for the first decoction. After the first decoction, add appropriate amount of water again for the second decoction. After the second decoction is completed, combine the decoctions after the two decoctions, filter to remove impurities, and obtain a preliminary extract for use.

[0028] Step 3, hydrolysis treatment: add 2-16 times the amount of sulfuric acid solution to the decocted medicinal residue, heat and hydrolyze until no brown particles appear in the solution, and obtain a hydrolyzate after the hydrolysis is completed. Filter the hydrolyzate to remove insoluble impurities, then adjust the pH value of the hydrolyzate to an appropriate range, filter it again, and combine the filtrate after pH adjustment with the preliminary extract to obtain a comprehensive extract.

[0029] Step 4: Concentration and alcohol precipitation: Concentrate the comprehensive extract to an appropriate volume, then add ethanol to it to make it reach a certain alcohol content, let it stand to allow impurities to precipitate, and then filter to remove the precipitate.

[0030] Step 5: Ethanol recovery and concentration: recover the ethanol in the filtrate and further concentrate the remaining liquid to a thick paste.

[0031] Step 6: Granulation and drying: Add appropriate amount of auxiliary materials to the thick paste, mix well, and make granules through a granulator. After the granules are dried, the finished antelope horn granules are obtained and packaged.

[0032] Specifically, the method comprises the following steps: according to the operation steps in step one, the antelope horn is selected from antelope horns that have been cleaned and crushed to a suitable fineness.

[0033] Specifically, the method comprises the following steps: according to the operation steps in step 2, the first decoction time is 2-6 hours, and the second decoction time is 2-5 hours.

[0034] Specifically, the process comprises the following steps: according to the operation steps in step three, the concentration of the sulfuric acid solution is 1-2 mol / L.

[0035] Specifically, the method comprises the following steps: according to the operation steps in step three, the pH value of the medicinal residue filtrate is adjusted using calcium hydroxide.

[0036] Specifically, the method comprises the following steps: according to the operation steps in step 4, the alcohol content is 75% to 85%.

[0037] Specifically, the method comprises the following steps: according to the operation steps in step 4, the static environment temperature is about 0°C.

[0038] Specifically, the method comprises the following steps: according to the operation steps in step five, the relative density of the thick paste is 1.05-1.20, and the temperature range of the thick paste when measuring the relative density is 50-60°C.

[0039] Specifically, according to the operation steps in step six, the auxiliary material is powdered sugar or dextrin.

[0040] Specifically, according to the operating steps in step six, the packaging of the finished antelope horn particles selects aluminum foil composite film as the packaging material.

[0041] The invention provides a preparation process of antelope horn particles, comprising the following steps: step one, raw material preparation: selecting 8-15 g of antelope horn of qualified quality as the raw material, wherein the antelope horn is selected from antelope horns that have been cleaned and crushed to a suitable fineness; step two, decoction extraction: adding an appropriate amount of water to the antelope horn for a first decoction, after the first decoction, adding an appropriate amount of water again for a second decoction, after the second decoction is completed, combining the decoctions after the two decoctions, filtering to remove impurities, and obtaining a preliminary extract for standby use, wherein the first decoction time is 2-6 hours to ensure that the drug components are fully dissolved, and the second decoction time is 2 -5 hours, through two decoctions, it can be ensured that the effective ingredients in the raw materials are fully extracted. The first decoction time is longer, and most of the easily soluble components can be extracted. Although the second decoction time is slightly shorter, it can further extract the remaining effective ingredients, ensuring that all the extracted effective ingredients are fully utilized, thereby improving the utilization rate of the drug. Step three, hydrolysis treatment: add 2-16 times the amount of sulfuric acid solution to the decocted drug residue, heat and hydrolyze until no brown particles appear in the solution, which can destroy the chemical structure of the insoluble or bound components in the drug residue and convert them into soluble components, so that they can be further The hydrolyzate is extracted and hydrolyzed to obtain a hydrolyzate. Heating and hydrolysis can ensure that the effective ingredients in the drug residue are fully utilized, reduce waste, and improve the overall drug utilization rate. The hydrolyzate is filtered to remove insoluble impurities, and then the pH value of the hydrolyzate is adjusted to a suitable range, and filtered again to improve the quality and safety of the drug. The filtrate after pH adjustment is combined with the preliminary extract to obtain a comprehensive extract. The pH value of the drug residue filtrate is adjusted by calcium hydroxide, which can neutralize the acidic substances produced by sulfuric acid hydrolysis, so that the pH value of the drug solution reaches a stable range, which is beneficial to the subsequent process steps and the stability of the final product. The concentration of the sulfuric acid solution is 1-2 mol / L. Step 4: Concentration and alcohol precipitation: Concentrate the comprehensive extract to an appropriate volume, then add ethanol to it to make it reach a certain alcohol content, let it stand to precipitate impurities, and then filter to remove the precipitate. The alcohol content is 75% to 85%. The ambient temperature of the standing environment is about 0°C, which can precipitate or separate impurities and unnecessary components in the liquid medicine. These impurities can be removed by filtration to improve the purity of the liquid medicine. Step 5: Ethanol recovery and concentration: Recover the ethanol in the filtrate and further concentrate the remaining liquid to a thick paste. The relative density of the thick paste is 1.05-1.20. The temperature range of the thick paste when measuring the relative density is 50-60°C, which can reduce the energy consumption and time in the subsequent drying and granulation steps and improve production efficiency. Step 6: Granulation and drying: Add appropriate amount of auxiliary materials to the thick paste, mix evenly, and make granules through a granulator. After the granules are dried, the finished antelope horn granules are obtained. The finished antelope horn granules are packaged. The auxiliary materials are selected from powdered sugar or dextrin, which can improve the taste and prevent the thick paste from stratification, precipitation or deterioration during storage. The packaging of the finished antelope horn granules uses aluminum foil composite film as the packaging material. The aluminum foil composite film has good moisture-proof properties. The sealed aluminum foil composite film can prevent the granules from absorbing moisture and agglomerating. .

[0042] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A process for preparing antelope horn particles, characterized in that: The following steps are involved: S1. Raw material preparation: Select 8-15g of qualified antelope horn as raw material; S2, decoction extraction: adding an appropriate amount of water to the antelope horn for the first decoction, adding an appropriate amount of water again for the second decoction after the first decoction, after the second decoction is completed, combining the decoctions after the two decoctions, filtering to remove impurities, and obtaining a preliminary extract for standby use; S3, hydrolysis treatment: adding 2-16 times the amount of sulfuric acid solution to the decocted medicinal residue, heating for hydrolysis, until no brown particles appear in the solution, obtaining a hydrolyzate after the hydrolysis is completed, filtering the hydrolyzate to remove insoluble impurities, and then adjusting the pH value of the hydrolyzate to a suitable range, filtering again, combining the filtrate after pH adjustment with the preliminary extract to obtain a comprehensive extract; S4, concentration and alcohol precipitation: the comprehensive extract is concentrated to an appropriate volume, and then ethanol is added to it to reach a certain alcohol content, and the mixture is allowed to stand to precipitate impurities, and then filtered to remove the precipitate; S5, ethanol recovery and concentration: recovering ethanol in the filtrate and further concentrating the remaining liquid into a thick paste; S6. Granulation and drying: Add appropriate amount of auxiliary materials to the thick paste, mix well, and make granules through a granulator. After the granules are dried, the finished antelope horn granules are obtained, and the finished antelope horn granules are packaged.

2. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The following steps are involved: According to the operating steps in S1, the antelope horns are selected from antelope horns that have been cleaned and crushed to a suitable fineness.

3. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The method comprises the following steps: according to the operation steps in S2, the first decoction time is 2-6 hours, and the second decoction time is 2-5 hours.

4. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The following steps are involved: According to the operation steps in S3, the concentration of the sulfuric acid solution is 1-2 mol / L.

5. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The following steps are involved: According to the operation steps in S3, the pH value of the medicinal residue filtrate is adjusted using calcium hydroxide.

6. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The following steps are involved: According to the operation steps in S4, the alcohol content is 75% to 85%.

7. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The following steps are involved: According to the operation steps in S4, the ambient temperature of the static state is about 0°C.

8. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The method comprises the following steps: according to the operation steps in S5, the relative density of the thick paste is 1.05-1.20, and the temperature range of the thick paste when measuring the relative density is 50-60°C.

9. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The following steps are involved: According to the operation steps in S6, the auxiliary material is powdered sugar or dextrin.

10. The process for preparing antelope horn-containing particles according to claim 1, characterized in that: The following steps are involved: According to the operating steps in S6, the finished antelope horn particles are packaged using an aluminum foil composite film as the packaging material.

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