Soluble microneedle patch preparation device

Abstract

The invention relates to the technical field of cosmetic preparation devices, and discloses a soluble microneedle patch preparation device which comprises an equipment box. The solution box is slidably mounted in an inner cavity of the equipment box; the forming frame is mounted at the bottom of the inner cavity of the equipment box; one end of a connecting shaft at the output end of a driving motor drives a cam to jack a forming frame, so that bubbles in a solution injected into a forming hole can be separated to the top of a cavity through vibration, and a rocker arm structure formed by a connecting rod and a connecting arm can push an upper sliding block to longitudinally slide in a sliding groove in a reciprocating mode at the hinged end; a lifting plate can move up and down under the cooperation of a transmission gear and a rack, and meanwhile, a bottom stirring blade shaft rod can axially rotate at the same time under the cooperation of a first bevel gear and a second bevel gear, so that two groups of symmetrical stirring blades in the solution box can synchronously move up and down, and meanwhile, a prepared solution can be stirred; bubbles at the solution box and the forming hole are fully stirred and removed, and are separated from the solution.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetic preparation devices, in particular to a soluble microneedle patch preparation device. Background Art

[0002] Microneedles are divided into two categories: solid microneedles and hollow microneedles. In addition to being made of insoluble materials, solid microneedles can also be made of soluble polymers; while hollow microneedles are generally made of insoluble materials and have openings at the tips, such as glass hollow microneedles, which are used for liquid injection.

[0003] For example, the Chinese patent authorization announcement number is CN222092321U, "discloses that the utility model provides a soluble microneedle patch preparation device, including a table board, a through opening is opened in the middle of the table board, and a support plate is arranged in the opening, and both sides of the support plate are connected to the table board through a connecting mechanism";

[0004] In the above-mentioned comparative document, a vibration mechanism is provided, and when the motor drives the cam to rotate, the supporting plate connected to the movable rod is driven by the connecting rod to move up and down, the spring is stretched, and the support plate is kept in a vibrating state. At the same time, the slider is driven to move in the slide groove of the vertical rod to maintain the stability of the movement of the support plate, and the bubbles in the soluble material are removed by vibration to ensure that the internal structure of the microneedle is denser, which helps to fill the material more evenly in the microneedle mold, thereby improving the quality and consistency of the microneedle.

[0005] When the above-mentioned soluble microneedle patch preparation device is in use, vibration is generated at the microneedle patch forming holes and the injection port to prevent the presence of bubbles in the formed microneedles. However, the bubbles dissolved between the solutions gathered in the solution box cannot be fully removed from the upper layer by vibration, and the bubbles in the forming holes in the solution box and the forming frame cannot be discharged in time, and will continue to dissolve into the liquid in the cavity, causing the microneedle molding to be not tight enough and affecting the subsequent solution preparation microneedle process. Summary of the invention

[0006] The object of the present invention is to provide a soluble microneedle patch preparation device, which can fully stir and remove the bubbles gathered at the bottom of the solution box, and at the same time, can timely discharge the gas in the solution box and the internal cavity of the molding frame to avoid re-dissolving into the solution, resulting in the internal solution of the microneedle not being molded tightly enough.

[0007] To achieve the above-mentioned object, the present invention provides the following technical solutions: a soluble microneedle patch preparation device, comprising an equipment box;

[0008] A solution box slidably mounted in the inner cavity of the equipment box and a forming frame mounted at the bottom of the inner cavity of the equipment box;

[0009] A synchronous drive mechanism is provided on one side of the equipment box, and the synchronous drive mechanism includes a drive motor fixedly installed on one side of the bottom of the equipment box, and the output end of the drive motor is fixedly connected to a connecting shaft. Pulleys are respectively installed on the side of the equipment box close to the synchronous drive mechanism, and belts are fixedly sleeved on two groups of the pulleys. A longitudinal reciprocating mechanism is provided on the side of the equipment box close to the synchronous drive mechanism, and the longitudinal reciprocating mechanism includes a connecting rod and a connecting arm. The connecting rod is hinged to the adjacent end of the connecting arm, and the end of the connecting rod away from the connecting arm is hinged to the side rotating shaft of one group of the pulleys;

[0010] A transmission mechanism is provided near the top of the inner cavity of the equipment box, and the transmission mechanism includes a lifting plate, sliders are fixedly installed at both ends of the lifting plate, and a connecting rod is rotatably installed between the two groups of sliders, and a first bevel gear is fixedly sleeved on the outside of the connecting rod near both ends, and a rack is fixedly installed on both sides of the outside of the equipment box, and stirring blades are rotatably installed on both sides of the bottom of the lifting plate, and a second bevel gear is fixedly sleeved on the shaft rod above the stirring blade, and the outer edge of the first bevel gear is meshed with the outer edge of the second bevel gear, and the end of the connecting rod near the rack is fixedly sleeved with a transmission gear, and the outer edge of the transmission gear is meshed with the outer edge of the rack on the same side, and the connecting arm is hinged on the same side end of the connecting rod away from the connecting rod;

[0011] Two groups of transverse reciprocating mechanisms are respectively arranged on one side of the outside of the equipment box close to the synchronous drive mechanism, and the transverse reciprocating mechanisms include connecting rods and guide rails, and the two ends of the connecting rods are respectively hinged with crankshafts and guide blocks, and the guide blocks slide inside the guide rails on the same side, and the crankshafts at the adjacent ends of the two groups of connecting rods are respectively fixedly connected to the corresponding two groups of pulley side rotating shafts;

[0012] Two groups of exhaust mechanisms are also provided on the side of the equipment box close to the synchronous drive mechanism. The exhaust mechanism includes an air cylinder fixed on the side of the equipment box close to the synchronous drive mechanism. The piston end of the air cylinder is fixedly connected to the end of the guide block on the same side. The air cylinder is fixedly connected to an air guide pipe away from the piston end. The two groups of air guide pipes are respectively connected to the solution tank and the forming frame. One-way valves are respectively installed on the air cylinder and the air guide pipe.

[0013] Preferably, a guard plate is fixedly installed on one side of the equipment box close to the synchronous drive mechanism, and the equipment box is a hollow structure with an opening at the bottom. One end of the crankshafts fixed on the outside of the two sets of pulleys are respectively rotatably installed on the inner wall of the guard plate, and the two sets of guide rails are respectively fixedly installed on the inner wall of the guard plate.

[0014] Preferably, slide grooves are respectively provided on both sides of the equipment box, and the two groups of sliding blocks slide in the corresponding inner walls of the slide grooves respectively, and an open groove is provided at the bottom of the equipment box.

[0015] Preferably, a liquid guide tube is fixedly passed through the top of the solution box, a hopper is fixedly passed through the top of the liquid guide tube, cylinders are fixedly installed on both sides of the top of the inner cavity of the equipment box, the telescopic ends of the cylinders are fixedly connected to the top of the solution box, and a liquid guide plate is fixedly formed at the bottom opening of the solution box, and the liquid guide plate and the liquid guide tube are both corrugated structures.

[0016] Preferably, the forming frame includes a connecting plate installed at the bottom of the inner cavity of the equipment box, a forming plate is detachably installed on the top of the connecting plate, forming holes are evenly spaced on the top of the forming plate, the interior of the connecting plate is a loose porous structure, and the connecting plate is connected to the forming holes, and the forming plate and the liquid guide plate are connected by a magnetic seal.

[0017] Preferably, the shaft above the stirring blade movably passes through the top of the solution box, and the blades below the stirring blade are located in the inner cavity of the solution box. A buffer seat is fixedly installed at the connection between the solution box and the liquid guide plate, and a buffer spring is fixedly installed inside the buffer seat, and a stop plate is fixedly connected to the top of the buffer spring.

[0018] Preferably, vibration mechanisms are respectively provided on both sides of the connecting plate, and the vibration mechanisms include reset springs respectively fixedly installed between the connecting plate and the inner cavity of the equipment box, and positioning seats are respectively fixedly installed on the connecting plate and the bottom of the equipment box, and one end of the connecting shaft at the output end of the drive motor is fixedly connected to a cam, and the cam movably passes through the opening groove and is hinged on the positioning seat at the bottom of the connecting plate.

[0019] Preferably, the connecting shaft at the output end of the driving motor is fixedly connected to the rotating shaft on one side of the pulley on the same straight line at one end away from the cam, and the length of the connecting rod is less than the linear spacing between the two groups of pulleys.

[0020] Preferably, the one-way valve on the gas cylinder is used to discharge the gas, and the one-way valve on the airway tube is used to prevent the backflow of the solution or gas inside the airway tube.

[0021] Preferably, the ends of the two groups of air guide tubes away from the air cylinder are respectively connected to the inner cavity of the solution tank and the connecting plate.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] The present invention drives the cam to lift the forming frame by driving one end of the connecting shaft at the output end of the motor, so that the connecting plate can vibrate back and forth through the return springs on both sides, so that the bubbles in the solution injected into the forming hole can be vibrated and separated to the top of the cavity, and the rocker arm structure formed by the connecting rod and the connecting arm can push the upper slider to slide back and forth longitudinally in the slide groove at the hinged end, and the lifting plate can move up and down under the cooperation of the transmission gear and the rack, and the bottom stirring blade shaft can rotate axially at the same time under the cooperation of the first bevel gear and the second bevel gear, so that the two groups of symmetrical stirring blades inside the solution box can move up and down synchronously and can also stir the prepared solution, so that the upper and lower layers of the microneedle preparation solution in the solution box can be fully stirred, so that the dissolved bubbles can be stirred and separated from the solution, and the bubbles in the solution box and the forming hole can be fully stirred and removed, and separated from the solution;

[0024] When the two groups of pulleys and the belts in the present invention are driven by a driving motor, the connecting rods hinged on the outside of the crankshafts fixed on the outsides of the two groups of pulleys can be driven synchronously, and the guide blocks hinged on the ends of the connecting rods can slide back and forth laterally in the guide rails, thereby driving the piston end of the air cylinder on the same side to be pulled back and forth laterally, and the air cylinder away from the piston end can periodically extract the gas in the solution box and the molding plate cavity through the air guide pipe, and with the cooperation of the one-way valve on the air cylinder, the gas can be discharged in time, so that the gas separated from the solution in the solution box and the cavity in the molding plate can be discharged in time, avoiding the gas from being re-dissolved in the preparation solution later, resulting in the solution inside the microneedle being not formed tightly enough. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0026] Figure 2 This is a schematic diagram of the internal structure of the solution tank in the present invention;

[0027] Figure 3 It is a schematic diagram of the side structure of the equipment box in the present invention;

[0028] Figure 4 It is a schematic diagram of the exhaust mechanism in the present invention;

[0029] Figure 5 It is a schematic diagram of the longitudinal reciprocating mechanism in the present invention;

[0030] Figure 6 It is a schematic diagram of the transverse reciprocating mechanism in the present invention;

[0031] Figure 7 for Figure 2 A schematic diagram of the partially enlarged structure at center A;

[0032] Figure 8 for Figure 3 A schematic diagram of the partially enlarged structure at B in the middle;

[0033] Fig. 9 for Figure 4 Schematic diagram of the partial enlarged structure at point C in the middle.

[0034] In the figure: 1, equipment box; 2, solution box; 3, forming frame; 4, vibration mechanism; 5, synchronous drive mechanism; 6, longitudinal reciprocating mechanism; 7, transmission mechanism; 8, transverse reciprocating mechanism; 9, exhaust mechanism; 10, stirring blade; 11, guard plate; 12, slide; 13, opening slot; 21, liquid guide tube; 22, hopper; 23, cylinder; 24, liquid guide plate; 31, connecting plate; 32, forming plate; 33, forming hole; 41, reset spring; 42, cam; 421, positioning Seat; 51, driving motor; 52, pulley; 53, belt; 61, connecting rod; 62, connecting arm; 71, lifting plate; 72, slider; 73, connecting rod; 74, first bevel gear; 75, rack; 76, second bevel gear; 721, transmission gear; 81, connecting rod; 82, crankshaft; 83, guide rail; 831, guide block; 91, air cylinder; 92, air guide tube; 93, one-way valve; 101, buffer seat; 102, buffer spring; 103, back plate. DETAILED DESCRIPTION

[0035] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. The described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0036] Embodiment 1:

[0037] This embodiment introduces a soluble microneedle patch preparation device, such as Figure 1 , Figure 2 as well as Figure 8 As shown, a soluble microneedle patch preparation device includes an equipment box 1;

[0038] A solution box 2 slidably mounted in the inner cavity of the equipment box 1 and a forming frame 3 mounted at the bottom of the inner cavity of the equipment box 1;

[0039] A synchronous drive mechanism 5 is provided on one side of the equipment box 1. The synchronous drive mechanism 5 includes a drive motor 51 fixedly installed on one side of the bottom of the equipment box 1. The output end of the drive motor 51 is fixedly connected to a connecting shaft. Pulleys 52 are respectively installed on the side of the equipment box 1 close to the synchronous drive mechanism 5. Belts 53 are fixedly sleeved on two groups of pulleys 52. A longitudinal reciprocating mechanism 6 is provided on the side of the equipment box 1 close to the synchronous drive mechanism 5. The longitudinal reciprocating mechanism 6 includes a connecting rod 61 and a connecting arm 62. The connecting rod 61 is hinged at the adjacent ends of the connecting arm 62. The end of the connecting rod 61 away from the connecting arm 62 is hinged to the side rotating shaft of one group of pulleys 52.

[0040] A transmission mechanism 7 is provided near the top of the inner cavity of the equipment box 1. The transmission mechanism 7 includes a lifting plate 71. Slide blocks 72 are fixedly installed at both ends of the lifting plate 71. A connecting rod 73 is rotatably installed between the two groups of slide blocks 72. A first bevel gear 74 is fixedly sleeved on the outside of the connecting rod 73 near both ends. Racks 75 are fixedly installed on both sides of the outside of the equipment box 1. Stirring blades 10 are rotatably installed on both sides of the bottom of the lifting plate 71. A second bevel gear 76 is fixedly sleeved on the shaft above the stirring blade 10. The outer edge of the first bevel gear 74 is meshed with the outer edge of the second bevel gear 76. A transmission gear 721 is fixedly sleeved on one end of the connecting rod 73 near the rack 75. The outer edge of the transmission gear 721 is meshed with the outer edge of the rack 75 on the same side. The end of the connecting arm 62 away from the connecting rod 61 is hinged to the same side end of the connecting rod 73;

[0041] In this embodiment, the stirring blade 10 is composed of a shaft in the middle and blades fixed outside. The stirring blade 10 can stir the solution for preparing the microneedle patch in the solution tank 2. The gas cylinder 91 is similar in structure to the gas injection cylinder. The piston end slides inside the cylinder to transfer the gas from one side to the other side. The one-way valve 93 on the gas cylinder 91 is connected to the exhaust hole. The one-way valve 93 on the air guide tube 92 can prevent the solution and gas in the solution tank 2 and the molding plate 32 from flowing back respectively.

[0042] In this embodiment, the cylinder 23 lifts the solution box 2 so that the solution box 2 can be connected to the molding frame 3. The buffer seat 101 inside the liquid guide plate 24 is provided with a liquid injection hole. After being magnetically connected to the molding plate 32, the solution can be injected into the molding hole 33, so that soluble microneedles can be prepared. The technical solution of the microneedle mold by liquid injection is a prior art and will not be described in detail here.

[0043] In this embodiment, the cam 42 is driven to lift the forming frame 3 by driving one end of the connecting shaft at the output end of the motor 51, so that the connecting plate 31 vibrates back and forth through the return springs 41 on both sides, so that the bubbles in the solution injected into the forming hole 33 can be vibrated and separated to the top of the cavity, and the other end of the connecting shaft at the output end of the driving motor 51 drives a group of pulleys 52 to rotate at the same time, and the two groups of pulleys 52 are synchronously transmitted through the belt 53, and the connecting rod 61 and the connecting arm 62 on the upper pulley 52 form a swingable rocker arm structure, which can push the upper slider 72 at the hinged end to slide back and forth longitudinally in the slide groove 12. The rotating transmission gear 721 on the outer side of the slider 72 rotates under the meshing of the rack 75, so that the connecting rod 73 inside the lifting plate 71 rotates, and the two groups of first bevel gears 74 on the connecting rod 73 transmit the second bevel gear 76 on the top of the shaft of the stirring blade 10, so that the two groups of symmetrical stirring blades 10 inside the solution box 2 can move up and down synchronously and stir the prepared solution at the same time, so that the upper and lower layers of the microneedle preparation solution in the solution box 2 can be fully stirred, so that the dissolved bubbles can be stirred and separated from the solution, and the bubbles in the solution box 2 and the forming hole 33 can be fully stirred and removed and separated from the solution;

[0044] Among them, a guard plate 11 is fixedly installed on one side of the equipment box 1 close to the synchronous drive mechanism 5. The equipment box 1 is a hollow structure with an opening at the bottom. One end of the crankshaft 82 fixed on the outside of the two sets of pulleys 52 is rotatably installed on the inner wall of the guard plate 11, and the two sets of guide rails 83 are fixedly installed on the inner wall of the guard plate 11. When the two sets of pulleys 52 and the belts 53 are driven by the driving motor 51, the connecting rods 81 hinged on the outside of the crankshafts 82 fixed on the outside of the two sets of pulleys 52 can be synchronously driven, and the guide block 831 hinged on the end of the connecting rod 81 can slide back and forth laterally in the guide rail 83.

[0045] Among them, slide grooves 12 are respectively opened on both sides of the equipment box 1, and two groups of sliders 72 slide in the corresponding inner walls of the slide grooves 12 respectively. An open groove 13 is opened at the bottom of the equipment box 1. The cam 42 is driven by one end of the connecting shaft at the output end of the driving motor 51 to lift the forming frame 3, so that the connecting plate 31 vibrates back and forth through the return springs 41 on both sides, so that the bubbles in the solution injected into the forming hole 33 can be vibrated and separated to the top of the cavity.

[0046] Among them, a liquid guide tube 21 is fixedly penetrated on the top of the solution box 2, and a hopper 22 is fixedly penetrated on the top of the liquid guide tube 21. Cylinders 23 are fixedly installed on both sides of the top of the inner cavity of the equipment box 1. The telescopic end of the cylinder 23 is fixedly connected to the top of the solution box 2. A liquid guide plate 24 is fixedly formed at the bottom opening of the solution box 2. Both the liquid guide plate 24 and the liquid guide tube 21 have corrugated structures. The forming frame 3 includes a connecting plate 31 installed at the bottom of the inner cavity of the equipment box 1. A forming plate 32 is detachably installed on the top of the connecting plate 31 by bolts. Forming holes 33 are arranged at equal intervals on the top of the forming plate 32. The interior of the connecting plate 31 is a loose porous structure, and the connecting plate 31 is connected to the forming holes 33. The forming plate 32 and the liquid guide plate 24 are connected by a magnetic seal. The cylinder 23 lifts the solution box 2 so that the solution box 2 can be connected to the forming frame 3. The buffer seat 101 inside the liquid guide plate 24 is provided with a liquid injection hole. After being magnetically connected to the forming plate 32, the solution can be injected into the forming hole 33.

[0047] Among them, the shaft above the stirring blade 10 movably passes through the top of the solution tank 2, and the blade below the stirring blade 10 is located in the inner cavity of the solution tank 2. A buffer seat 101 is fixedly installed at the connection between the solution tank 2 and the liquid guide plate 24, and a buffer spring 102 is fixedly installed inside the buffer seat 101. The top of the buffer spring 102 is fixedly connected to a support plate 103. The two groups of symmetrical stirring blades 10 inside the solution tank 2 can move up and down synchronously. At the same time, when stirring the prepared solution, the bottom end of the shaft of the stirring blade 10 can buffer the support plate 103 and the buffer spring 102 inside the buffer seat 101 in the solution tank 2.

[0048] Among them, vibration mechanisms 4 are respectively arranged on both sides of the connecting plate 31, and the vibration mechanism 4 includes reset springs 41 respectively fixedly installed between the connecting plate 31 and the inner cavity of the equipment box 1, and positioning seats 421 are respectively fixedly installed on the connecting plate 31 and the bottom of the equipment box 1, and one end of the connecting shaft at the output end of the driving motor 51 is fixedly connected with a cam 42, and the cam 42 movably penetrates the opening groove 13 and is hinged on the positioning seat 421 at the bottom of the connecting plate 31. The cam 42 is driven by one end of the connecting shaft at the output end of the driving motor 51 to lift the forming frame 3, so that the cam 42 can movably penetrate the opening groove 13, and the connecting plate 31 is reciprocated and vibrated through the reset springs 41 on both sides.

[0049] Among them, the connecting shaft at the output end of the driving motor 51 is fixedly connected to the rotating shaft on one side of the pulley 52 on the same straight line away from the cam 42, and the length of the connecting rod 61 is less than the linear spacing between the two groups of pulleys 52. The other end of the connecting shaft at the output end of the driving motor 51 simultaneously drives a group of pulleys 52 to rotate, and the two groups of pulleys 52 are synchronously transmitted through the belt 53, and the connecting rod 61 and the connecting arm 62 on the upper pulley 52 form a swingable rocker arm structure, which can push the upper slider 72 at the hinged end to slide back and forth longitudinally in the slide groove 12.

[0050] Embodiment 2:

[0051] Based on Example 1, this example introduces a soluble microneedle patch preparation device, such as Figure 3-Figure 4 as well as Fig. 9 As shown, two sets of transverse reciprocating mechanisms 8 are respectively arranged on one side of the outside of the equipment box 1 near the synchronous drive mechanism 5. The transverse reciprocating mechanism 8 includes a connecting rod 81 and a guide rail 83. The two ends of the connecting rod 81 are respectively hinged with a crankshaft 82 and a guide block 831. The guide block 831 slides inside the guide rail 83 on the same side. The crankshafts 82 at the adjacent ends of the two sets of connecting rods 81 are respectively fixedly connected to the side rotating shafts of the corresponding two sets of pulleys 52.

[0052] Two groups of exhaust mechanisms 9 are also provided on the side of the equipment box 1 close to the synchronous drive mechanism 5. The exhaust mechanism 9 includes an air cylinder 91 fixed on the side of the equipment box 1 close to the synchronous drive mechanism 5. The piston end of the air cylinder 91 is fixedly connected to the end of the guide block 831 on the same side. The air cylinder 91 is fixedly connected to an air guide pipe 92 away from the piston end. The two groups of air guide pipes 92 are respectively connected to the solution box 2 and the forming frame 3. One-way valves 93 are respectively installed on the air cylinder 91 and the air guide pipe 92.

[0053] In this embodiment, when the two groups of pulleys 52 and the belt 53 are driven by the driving motor 51, the connecting rods 81 respectively hinged on the outside of the crankshafts 82 fixed on the outside of the two groups of pulleys 52 can be synchronously driven, and the guide block 831 hinged on the end of the connecting rod 81 can slide back and forth laterally in the guide rail 83, thereby driving the piston end of the air cylinder 91 on the same side to be able to be pulled back and forth laterally, and the air cylinder 91 away from the piston end can periodically extract the gas in the solution box 2 and the cavity of the molding plate 32 respectively through the air guide pipe 92, and with the cooperation of the one-way valve 93 on the air cylinder 91, the gas can be discharged in time, so that the gas separated from the solution in the cavity of the solution box 2 and the molding plate 32 can be discharged in time, avoiding the subsequent re-dissolution into the preparation solution, resulting in the internal solution of the microneedle being not tightly formed;

[0054] Among them, the one-way valve 93 on the gas cylinder 91 is used to discharge the gas, and the one-way valve 93 on the air guide tube 92 is used to prevent the backflow of the solution or gas inside the air guide tube 92. The two sets of air guide tubes 92 are respectively connected to the inner cavity of the solution tank 2 and the connecting plate 31 at one end away from the gas cylinder 91. The piston end of the gas cylinder 91 is pulled back and forth horizontally, so that the gas cylinder 91 away from the piston end can periodically extract the gas in the solution tank 2 and the cavity of the forming plate 32 through the air guide tube 92. With the cooperation of the one-way valve 93 on the gas cylinder 91, the gas can be discharged in time.

[0055] Working principle: When in use, the soluble microneedle preparation solution is first introduced into the solution box 2 through the hopper 22 through the liquid guide tube 21, and then the valve is closed to isolate it from the outside air, and then the cylinder 23 lifts the solution box 2 so that the solution box 2 can be connected with the molding frame 3. The buffer seat 101 inside the liquid guide plate 24 is provided with a liquid injection hole, which can be connected to the molding plate 32 by magnetic attraction, and the solution can be injected into the molding hole 33;

[0056] At the same time, one end of the connecting shaft at the output end of the driving motor 51 drives the cam 42 to lift the forming frame 3, so that the connecting plate 31 can vibrate back and forth through the return springs 41 on both sides, so that the bubbles in the solution injected into the forming hole 33 can be vibrated and separated to the top of the cavity, and the other end of the connecting shaft at the output end of the driving motor 51 simultaneously drives a set of pulleys 52 to rotate, and the two sets of pulleys 52 are synchronously transmitted through the belt 53, and the upper connecting rod 61 and the connecting arm 62 can push the slider 72 at the hinged end to slide back and forth longitudinally in the slide groove 12. The rotating transmission gear 721 on the outer side of the slider 72 rotates under the meshing of the rack 75, so that the connecting rod 73 inside the lifting plate 71 rotates, and the two groups of first bevel gears 74 on the connecting rod 73 transmit the second bevel gear 76 on the top of the shaft of the stirring blade 10, so that the two groups of symmetrical stirring blades 10 inside the solution tank 2 can move up and down synchronously and stir the prepared solution at the same time, so that the upper and lower layers of the microneedle preparation solution in the solution tank 2 can be fully stirred, so that the dissolved bubbles can be stirred and separated from the solution;

[0057] When the two sets of pulleys 52 and the belt 53 are driven by the driving motor 51, the connecting rods 81 hinged on the outside of the crankshafts 82 fixed on the outside of the two sets of pulleys 52 can be driven synchronously, and the guide blocks 831 hinged on the ends of the connecting rods 81 can slide back and forth laterally in the guide rails 83, thereby driving the piston end of the air cylinder 91 on the same side to be pulled back and forth laterally, and the air cylinder 91 away from the piston end can periodically extract the gas in the solution box 2 and the cavity of the forming plate 32 through the air guide pipe 92, and with the cooperation of the one-way valve 93 on the air cylinder 91, the gas can be discharged in time, thereby achieving the timely discharge of the gas separated from the solution in the cavity of the solution box 2 and the forming plate 32.

[0058] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes and modifications may be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A soluble microneedle patch preparation device, comprising an equipment box (1); The solution box (2) is slidably mounted in the inner cavity of the equipment box (1) and the forming frame (3) is mounted at the bottom of the inner cavity of the equipment box (1), characterized in that: A synchronous drive mechanism (5) is provided on one side of the equipment box (1), and the synchronous drive mechanism (5) includes a drive motor (51) fixedly mounted on one side of the bottom of the equipment box (1), and the output end of the drive motor (51) is fixedly connected to a connecting shaft. Pulleys (52) are respectively installed on one side of the equipment box (1) close to the synchronous drive mechanism (5), and belts (53) are fixedly sleeved on two groups of the pulleys (52). A longitudinal reciprocating mechanism (6) is provided on one side of the equipment box (1) close to the synchronous drive mechanism (5), and the longitudinal reciprocating mechanism (6) includes a connecting rod (61) and a connecting arm (62). The connecting rod (61) is hinged to the adjacent ends of the connecting arm (62), and the end of the connecting rod (61) away from the connecting arm (62) is hinged to the side rotating shaft of one group of the pulleys (52); A transmission mechanism (7) is arranged near the top of the inner cavity of the equipment box (1), and the transmission mechanism (7) comprises a lifting plate (71), and sliders (72) are respectively fixedly installed at both ends of the lifting plate (71), and a connecting rod (73) is rotatably installed between two groups of the sliders (72), and first bevel gears (74) are respectively fixedly sleeved on the outside of the connecting rod (73) near both ends, and racks (75) are respectively fixedly installed on both sides of the outside of the equipment box (1), and the bottom two sides of the lifting plate (71) are respectively A stirring blade (10) is rotatably mounted thereon, a second bevel gear (76) is fixedly sleeved on the shaft above the stirring blade (10), the outer edge of the first bevel gear (74) is meshed with the outer edge of the second bevel gear (76), a transmission gear (721) is fixedly sleeved on one end of the connecting rod (73) close to the rack (75), the outer edge of the transmission gear (721) is meshed with the outer edge of the rack (75) on the same side, and the end of the connecting arm (62) away from the connecting rod (61) is hinged to the same side end of the connecting rod (73); Two groups of transverse reciprocating mechanisms (8) are respectively arranged on the outside of the equipment box (1) and on one side close to the synchronous drive mechanism (5), and the transverse reciprocating mechanisms (8) include connecting rods (81) and guide rails (83), and the two ends of the connecting rods (81) are respectively hinged with crankshafts (82) and guide blocks (831), and the guide blocks (831) slide inside the guide rails (83) on the same side, and the crankshafts (82) at the adjacent ends of the two groups of connecting rods (81) are respectively fixedly connected to the side rotating shafts of the corresponding two groups of pulleys (52); Two groups of exhaust mechanisms (9) are also provided on the side of the equipment box (1) close to the synchronous drive mechanism (5), and the exhaust mechanisms (9) include an air cylinder (91) fixed to the side of the equipment box (1) close to the synchronous drive mechanism (5), the piston end of the air cylinder (91) is fixedly connected to the end of the guide block (831) on the same side, and the air cylinder (91) is fixedly connected to an air guide pipe (92) away from the piston end, and the two groups of air guide pipes (92) are respectively connected to the solution box (2) and the forming frame (3), and one-way valves (93) are respectively installed on the air cylinder (91) and the air guide pipe (92).

2. A soluble microneedle patch preparation device according to claim 1, characterized in that: A guard plate (11) is fixedly mounted on one side of the equipment box (1) close to the synchronous drive mechanism (5); the equipment box (1) is a hollow structure with an open bottom; one end of the crankshaft (82) fixed on the outside of the two sets of pulleys (52) is rotatably mounted on the inner side wall of the guard plate (11); and the two sets of guide rails (83) are fixedly mounted on the inner side wall of the guard plate (11).

3. A soluble microneedle patch preparation device according to claim 2, characterized in that: Slide grooves (12) are respectively provided on both sides of the equipment box (1), and the two groups of sliders (72) slide in the corresponding inner walls of the slide grooves (12) respectively. An open groove (13) is provided at the bottom of the equipment box (1).

4. A soluble microneedle patch preparation device according to claim 3, characterized in that: A liquid guide tube (21) is fixedly passed through the top of the solution box (2), a hopper (22) is fixedly passed through the top of the liquid guide tube (21), cylinders (23) are fixedly installed on both sides of the top of the inner cavity of the equipment box (1), the telescopic end of the cylinder (23) is fixedly connected to the top of the solution box (2), and a liquid guide plate (24) is fixedly formed at the bottom opening of the solution box (2), and both the liquid guide plate (24) and the liquid guide tube (21) are of corrugated structure.

5. A soluble microneedle patch preparation device according to claim 4, characterized in that: The forming frame (3) comprises a connecting plate (31) installed at the bottom of the inner cavity of the equipment box (1); a forming plate (32) is detachably installed on the top of the connecting plate (31); forming holes (33) are arranged at equal intervals on the top of the forming plate (32); the interior of the connecting plate (31) is a loose porous structure, and the connecting plate (31) is connected to the forming holes (33); the forming plate (32) and the liquid guide plate (24) are connected by magnetic sealing.

6. A soluble microneedle patch preparation device according to claim 5, characterized in that: The shaft above the stirring blade (10) movably passes through the top of the solution box (2), and the blade below the stirring blade (10) is located in the inner cavity of the solution box (2). A buffer seat (101) is fixedly installed at the connection between the solution box (2) and the liquid guide plate (24), and a buffer spring (102) is fixedly installed inside the buffer seat (101), and the top of the buffer spring (102) is fixedly connected to a stop plate (103).

7. A soluble microneedle patch preparation device according to claim 6, characterized in that: Vibration mechanisms (4) are respectively arranged on both sides of the connection plate (31), and the vibration mechanisms (4) include return springs (41) respectively fixedly mounted between the connection plate (31) and the inner cavity of the equipment box (1), and positioning seats (421) are respectively fixedly mounted on the connection plate (31) and the bottom of the equipment box (1), and one end of the connecting shaft at the output end of the drive motor (51) is fixedly connected to a cam (42), and the cam (42) movably penetrates the opening slot (13) and is hinged on the positioning seat (421) at the bottom of the connection plate (31).

8. A soluble microneedle patch preparation device according to claim 7, characterized in that: The end of the connecting shaft at the output end of the driving motor (51) away from the cam (42) is fixedly connected to a rotating shaft on one side of the belt pulley (52) on the same straight line, and the length of the connecting rod (61) is less than the linear distance between the two groups of the belt pulleys (52).

9. A soluble microneedle patch preparation device according to claim 8, characterized in that: The one-way valve (93) on the gas cylinder (91) is used to discharge the gas, and the one-way valve (93) on the air guide tube (92) is used to prevent the backflow of the solution or gas inside the air guide tube (92).

10. A soluble microneedle patch preparation device according to claim 9, characterized in that: The ends of the two groups of air guide tubes (92) away from the air cylinder (91) are respectively connected to the inner cavity of the solution box (2) and the connecting plate (31).

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