Tumor electric field treatment system

Abstract

The invention provides a tumor electric field treatment system which comprises an electric field generator and a plurality of electrode patches arranged in pairs, the plurality of pairs of electrode patches comprise a pair of first electrode patches and a pair of second electrode patches, and the first electrode patches and the second electrode patches are each provided with a plurality of electrode units. The plurality of electrode units are respectively arranged on a plurality of rows and columns, the centers of the plurality of electrode units located on the same row of the first electrode patch are located on the same arc line, and the centers of the plurality of electrode units located on the same row of the second electrode patch are located on the same horizontal line. The tumor electric field treatment system comprises the first electrode patch and the second electrode patch, the electrode unit distribution modes of the first electrode patch and the second electrode patch are different, the current density mean value of the first electrode patch is low, the current density uniformity of the second electrode patch is better, and the tumor electric field treatment effect is better. Corresponding electrode patches can be attached to different areas of a patient.

Description

Technical Field

[0001] The present application relates to a tumor electric field treatment system. Background Art

[0002] Medium frequency alternating electric field therapy has been proven to be an effective method for tumor treatment. It can interfere with the mitosis process of cancer cells, induce apoptosis of cancer cells, and can be used to treat tumors. The tumor electric field therapy system usually includes an electric field generator, an adapter, and multiple pairs of electrode patches. The electric field generator generates an alternating electric signal and transmits the alternating electric signal to the electrode patch through the adapter. The electrode patches are applied in pairs on the surfaces of opposite sides of the patient's skin, and an alternating current signal is applied between each pair of electrode patches to non-invasively apply the tumor treatment electric field to the target area.

[0003] The electrode patch is equipped with several electrode units. During electric field therapy, each electrode unit transfers heat to the outside. The system will monitor the temperature of each electrode unit in real time. When the temperature of any electrode unit reaches a threshold, the system will reduce the electric field strength to reduce the temperature of the corresponding electrode unit to avoid low-temperature burns to the patient. Studies have found that due to the influence of the edge effect, the electrode units at the edge of the electrode patch are more likely to heat up. The so-called edge effect refers to the phenomenon of a sudden increase in local current density caused by the superposition of electromagnetic field vectors at the edge of the electrode patch. The increase in local current density will cause the heat generated in the corresponding part of the electrode patch to increase. The local accumulation of heat will cause the temperature of the corresponding electrode unit to exceed the threshold, and the system needs to reduce the applied electric field strength. The uneven distribution of heat on the entire electrode patch will cause the output energy of the entire electrode patch to decrease due to the temperature of a single point exceeding the threshold, resulting in poor treatment effect.

[0004] Therefore, there is a need to improve the existing tumor electric field therapy system and its electrode patch to overcome the problems described in the background technology. Summary of the invention

[0005] The present application provides a tumor electric field treatment system, which applies electrode patches with different performances to different areas, thereby improving the uniformity of the overall current density of the electrode array and the effectiveness of electric field transmission.

[0006] Specifically, the present application is implemented through the following technical scheme: a tumor electric field treatment system, comprising an electric field generator and a plurality of electrode patches arranged in pairs, the plurality of pairs of electrode patches comprising a pair of first electrode patches and a pair of second electrode patches, the first electrode patches and the second electrode patches are each provided with a plurality of electrode units, the plurality of electrode units are arranged in a plurality of rows and columns, wherein the centers of the plurality of electrode units in the same row of the first electrode patch are on the same arc line, and the centers of the plurality of electrode units in the same row of the second electrode patch are on the same horizontal line.

[0007] Furthermore, the first electrode patch and the second electrode patch are provided with a plurality of electrode units of the same number, and the plurality of electrode units of the first electrode patch and the second electrode patch are symmetrically arranged along a horizontal center line and a vertical center line, respectively; in the first electrode patch, the two ends of the arc where the electrode units located on the upper side of the horizontal center line are located are arranged in an upward shape, and the two ends of the arc where the electrode units located on the lower side of the horizontal center line are located are arranged in a downward pressed shape.

[0008] Furthermore, the first electrode patch and the second electrode patch each include twenty electrode units distributed in four rows and six columns, and two adjacent electrode units and a connecting portion arranged between the two electrode units constitute an electrode unit group, wherein the first row and the fourth row are respectively provided with two electrode unit groups, and the third row and the fourth row are respectively provided with three electrode unit groups, and the electrode units are provided with a dielectric layer, and the dielectric layers of the two electrode units in the electrode unit group also cover the connecting portion between the two electrode units and are continuously arranged.

[0009] Furthermore, in the first electrode patch, the electrode unit group located between the second row and the third row is arranged horizontally, and the other electrode unit groups are arranged obliquely, and the angle between the line connecting the centers of the two electrode units of the inclined electrode unit group and the horizontal line is 8°-12°.

[0010] Furthermore, the diameter of the electrode unit is 18 mm-22 mm, and the center distance between two electrode units in the electrode unit group is 32 mm-35 mm.

[0011] Furthermore, the arcs where the centers of the electrode units in each of the electrode unit groups in the first to fourth rows of the first electrode patch are located are H1, H2, H3 and H4 respectively, wherein the curvature of arc H1 is greater than the curvature of arc H2, and the curvature of arc H4 is greater than the curvature of arc H3.

[0012] Furthermore, the center angle of the arc segment occupied by the electrode unit group on the arc H1 is 11°-21°.

[0013] Furthermore, the center angle corresponding to the arc segment occupied by the corresponding electrode unit group on the arc H2 is 7°-11°.

[0014] Furthermore, the horizontal lines where the centers of the electrode units in each of the electrode unit groups in the first to fourth rows of the second electrode patch are located are L1, L2, L3 and L4 respectively, and the vertical distance between adjacent horizontal lines is greater than the vertical distance between two of the electrode units located in the second column and respectively in the first and second rows in the first electrode patch.

[0015] Furthermore, the horizontal distance of the gap between the two electrode unit groups in the first row of the first electrode patch is greater than the horizontal distance of the gap between the two electrode unit groups in the second row of the first electrode patch; the horizontal distance of the gap between the two electrode unit groups in the same row of the second electrode patch is greater than the horizontal distance of the gap between the two electrode unit groups in the first row of the first electrode patch.

[0016] The tumor electric field therapy system of the present application includes a first electrode patch and a second electrode patch. The first electrode patch and the second electrode patch have the same number of electrode units but different distribution methods. The first electrode patch has a lower current density mean value, and the second electrode patch has better current density uniformity. Corresponding electrode patches can be applied to different areas of the patient to pursue the uniformity of the overall current density of the electrode array and the high efficiency of electric field transmission.

[0017] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 is a framework diagram of a tumor electric field treatment system according to one embodiment of the present application;

[0019] Figure 2 is a plan view of a first electrode patch according to one embodiment of the present application;

[0020] Figure 3 for Figure 2 A plan view of an electrode array of a first electrode patch in FIG.

[0021] Figure 4 for Figure 3 A plan view of the substrate of the electrode array after the front conductive layer is provided;

[0022] Figure 5 for Figure 3 A plan view of a single electrode unit group of an electrode array;

[0023] Figure 6 For along Figure 3 The cross-sectional view obtained along the AA line;

[0024] Figure 7 for Figure 3 A distribution diagram of electrode unit groups of an electrode array in FIG.

[0025] Figure 8 is a plan view of a second electrode patch according to one embodiment of the present application;

[0026] Fig. 9 for Figure 8a distribution diagram of electrode unit groups of an electrode array of a second electrode patch;

[0027] Fig.10 A distribution diagram of electrode units of an electrode array in an electrode patch in the prior art;

[0028] Fig.11 for Figure 2 Each electrode unit in the first electrode patch, Figure 8 Each electrode unit in the second electrode patch and Fig.10 Comparison of current density differences among electrode units in the electrode patch.

[0029] Description of reference numerals:

[0030] Tumor electric field therapy system 100, electric field generator 10, adapter 20, first electrode patch 30, first backing 31, first electrode array 32, electrode unit group C, C1-C10, electrode unit 320, temperature sensor 321, connecting part 322, boundary line 3221, wiring part 323, gold finger 3231, substrate 341, main body 3411, connecting strip 3412, conductive sheet 342, opening 3421, pad 343, dielectric layer 344, insulating layer 345, alloy layer 346, first adhesive 33, second electrode patch 40, second electrode array 42, electrode unit 420. DETAILED DESCRIPTION

[0031] Here, exemplary embodiments will be described in detail, examples of which are shown in the accompanying drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. Instead, they are only examples of devices, systems, equipment and methods consistent with some aspects of the present application.

[0032] refer to Figure 1 As shown, the tumor electric field treatment system 100 includes an electric field generator 10, an adapter 20, and a plurality of electrode patches 30, 40 arranged in pairs, and the adapter 20 electrically connects the electric field generator 10 and each electrode patch. The electric field generator 10 generates an alternating current signal that meets the treatment requirements, and the adapter 20 receives the alternating current signal output from the electric field generator 10 and transmits the alternating current signal to the electrode patches 30, 40. The electrode patches 30, 40 are attached to the surface of the patient's body corresponding to the tumor area, and the alternating current signal is applied to the patient's tumor area for tumor electric field treatment. The present application provides a first electrode patch 30 (see Figure 2 ) and the second electrode patch 40 (refer to Figure 8 ) Two similar electrode patches, the structure of the first electrode patch 30 is first described below.

[0033] refer to Figure 2 and Figure 3 As shown, the first electrode patch 30 includes a first backing 31, a first electrode array 32 attached to the front of the first backing 31, and a plurality of first adhesive members 33 attached to the front of the first electrode array 32, wherein the front of the first backing 31, the first electrode array 32, and the first adhesive member 33 are all the sides facing the patient's skin. The first electrode array 32 includes twenty electrode units 320 arranged at intervals and eight temperature sensors 321 selectively arranged on eight of the electrode units 320. The electrode units 320 apply an alternating current signal to the patient, and the temperature sensors 321 can feedback the temperature of the corresponding electrode unit 320 attached to the body surface to prevent the heat generated by the electrode unit 320 when applying the alternating current signal from causing burns to the patient's body surface skin. The first adhesive member 33 is arranged in a sheet shape, covering each electrode unit 320, and is attached to the corresponding body surface of the patient's tumor when in use. The first adhesive member 33 is a conductive hydrogel, which can enhance the comfort of the electrode unit 320 and the patient's body surface, and can also be used as a conductive medium for the alternating current signal passing through the electrode unit 320 to pass through and be applied to the patient's tumor site.

[0034] The first electrode array 32 includes a connecting portion 322 connecting two adjacent electrode units 320 and a wiring portion 323 extending outward from one of the connecting portions 322. A gold finger 3231 is provided on the wiring portion 323. The wiring portion 323 is welded or detachably connected to a wire (not shown). The wire (not shown) is used to electrically connect the first electrode patch 30 to the adapter 20 to receive the alternating current signal from the electric field generator 10 and transmit the temperature detection signal of each temperature sensor 321 to the electric field generator 10.

[0035] The twenty electrode units 320 are arranged in an array of four rows and six columns. The first and fourth rows are each provided with four electrode units 320, and the second and third rows are each provided with six electrode units 320. The six electrode units 320 in each row of the second and third rows correspond to each other one by one and are roughly arranged in six columns. The four electrode units 320 in each row of the first and fourth rows are respectively located in the middle four columns. The twenty electrode units 320 are numbered 1-20 from left to right and from top to bottom. The multiple electrode units 320 located in the same row are not distributed along a horizontal line, but are roughly distributed along an arc line, wherein the electrode units 320 located in the first and second rows are distributed on the arc lines that are upturned at both ends, and the electrode units 320 located in the third and fourth rows are distributed on the arc lines that are pressed down at both ends. This shape design makes the first electrode array 32 more suitable for application to areas with large undulations on the skin surface and prone to large deformations, such as the armpits and the left and right sides of the human body. This can improve the adhesion of the first electrode patch 30 and avoid wrinkles during application.

[0036] Each row of the first electrode array 32 includes two adjacent electrode units 320 from left to right and a connecting portion 322 between the two electrode units 320, which constitute an electrode unit group C. The twenty electrode units 320 constitute ten electrode unit groups C in total. Figure 3 As shown, from left to right and from top to bottom, they are: electrode unit groups C1-C10, and the shape of a single electrode unit group C is set in a dumbbell shape. There are ten first adhesive members 33 in total, and the shape of the first adhesive member 33 is roughly the same as that of a single electrode unit group C and is also set in a dumbbell shape, and its size is slightly larger than that of the electrode unit group C, and covers each electrode unit group C accordingly.

[0037] Combination Figure 4 and Figure 6 As shown, the first electrode array 32 includes a flexible substrate 341 in a sheet shape. The substrate 341 serves as a support layer. Each electrode unit 320, each connection portion 322 and the wiring portion 323 are formed by further providing other structures on the front and / or bottom surface of the corresponding part of the substrate 341. The portion of the substrate 341 corresponding to each electrode unit 320 is the main body 3411, and the portion of the substrate 341 corresponding to each connection portion 322 and the wiring portion 323 is the connecting strip 3412. The main body 3411 is in a circular sheet shape, and the electrode unit 320 is provided with a conductive sheet 342 on the main body 3411. The conductive sheet 342 is in a circular ring shape, and a through opening 3421 is provided at the center. In other embodiments, the main body 3411 can also be in a triangular, polygonal, elliptical or other shape, and the conductive sheet 342 is provided in accordance with the shape of the main body 3411. The temperature sensor 321 is placed in the opening 3421 of the conductive sheet 342 of the corresponding electrode unit 320, and a pair of pads 343 are provided on the main body 3411, which are welded to the temperature sensor 321. There are also a number of conductive traces (not shown) on the front and back sides of the substrate 341, which are used to transmit AC signals to each conductive sheet 342, transmit DC signals for temperature measurement to the corresponding pads 343, or ground the corresponding pads 343. The conductive sheet 342, the pads 343, the conductive traces (not shown) on the front side of the substrate 341, and the gold fingers 3231 form the front conductive layer of the first electrode array 32. Figure 4 Conductive traces are omitted (not shown).

[0038] refer to Figure 3 , Figure 5 and Figure 6As shown, the first electrode array 32 also includes a dielectric layer 344 covering the conductive sheet 342 and electrically connected to the conductive sheet 342. The dielectric layer 344 is laid separately for each electrode unit group C, that is, the dielectric layer 344 between each electrode unit group C is disconnected, and the dielectric layers 344 of the two electrode units 320 in each electrode unit group C are continuously arranged by covering the connecting portion 322 in the corresponding electrode unit group C. The dielectric layer 344 enables the two electrode units 320 in each electrode unit group C to apply an AC signal at the same time. The shape of the dielectric layer 344 corresponding to each electrode unit group C is consistent with the shape of the electrode unit group C and is arranged in a dumbbell shape. The dielectric layer 344 can completely cover the corresponding conductive sheet 342 to prevent the conductive sheet 342 from directly contacting the human body to generate direct current conduction and affect the safety of the human body. The edge of the dielectric layer 344 does not exceed the outer contour of the substrate 341 so that the dielectric layer 344 can obtain full support from the substrate 341. The dielectric layer 344 can be made of ceramic material, or a polymer dielectric layer with high dielectric constant and low dielectric loss, which is made of a thin film material with non-fixed crystal orientation, high flexibility and high toughness. In this embodiment, the dielectric layer 344 is a polymer dielectric layer.

[0039] Combination Figure 6 As shown, the first electrode array 32 also includes an insulating layer 345. After the front conductive layer (unnumbered) is set and before the dielectric layer 344 is set, the insulating layer 345 is laid on the substrate 341 to form a solder resist layer located on the substrate 341. The insulating layer 345 needs to avoid the pad 343 and expose part of the conductive sheet 342 to avoid affecting the electrical connection between the pad 343 and the corresponding temperature sensor 321, and the conductive sheet 342 and the corresponding dielectric layer 344. The insulating layer 345 can reduce the heat transfer from the conductive sheet 342 to the dielectric layer 344, and play a role in heat insulation. The alloy layer 346 is further selectively laid on the dielectric layer 344, and the first adhesive member 33 is attached to the alloy layer 346. The alloy layer 346 is used as an auxiliary layer to increase the conductivity between the dielectric layer 344 and the first adhesive member 33.

[0040] refer to Figure 5 As shown, the structure of each electrode unit group C is the same, and as mentioned above, it is arranged in a dumbbell shape. The electrode unit group C is provided with a horizontal axis X1 and a vertical axis Y1, and the electrode unit group C is symmetrically arranged along the horizontal axis X1 and the vertical axis Y1. The center distance between the two electrode units 320 in a single electrode unit group C is 32-35mm, preferably 33.5mm, and the radius of a single electrode unit 320 is 9-11mm, preferably 11mm; the boundary line 3221 of the connecting portion 322 in the electrode unit group C is two arcs symmetrical in the upper and lower parts, and the center angle corresponding to the boundary line 3221 is 40°-44°, preferably 42°, and the boundary line 3221 on the upper side is arranged in an upward shape at both ends, and the boundary line 3221 on the lower side is arranged in a downward pressure shape at both ends.

[0041] Figure 7 3 is a distribution diagram of ten electrode unit groups C of the first electrode patch 30. It can be understood that only the electrode unit groups C covered with the dielectric layer 344 on the first electrode patch 30 are effective areas for applying the AC electric field, and other parts basically do not affect the current distribution of the AC electric field. Figure 7 Other parts are omitted. Figure 7 As shown, the electrode unit groups C1, C2, C3, C5, C6, C8, C9, and C10 located at the outer edge of the first electrode patch 30 are defined as the outer electrode unit group C, and the electrode unit groups C4 and C7 located at the center of the first electrode patch 30 are defined as the central electrode unit group C. At least a portion of the perimeter of each outer electrode unit group C constitutes the outer boundary M of the entire first electrode array 32, and the portion of the outer boundary M overlapping with each outer electrode unit group C does not exceed 10% of the perimeter of each outer electrode unit group C. The outer boundary M also has a concave portion and a convex portion. Specifically, its upper and lower edges are set in a concave shape, and the left and right edges are set in a convex shape. The area where these ten electrode unit groups C are located is provided with a horizontal center line X2 and a vertical center line Y2, and these ten electrode unit groups C are symmetrically arranged along the horizontal center line X2 and the vertical center line Y2, and the intersection of the horizontal center line X2 and the vertical center line Y2 is the center point of these ten electrode unit groups C.

[0042] The electrode unit groups C4 and C7 located at the center of the second row and the third row are horizontally arranged, that is, the horizontal axis X1 of the electrode unit groups C4 and C7 is a horizontal line parallel to the horizontal center line X2, and the other electrode unit groups C are inclined relative to the horizontal center line X2, so that the center (i.e., the center of the circle) of each electrode unit 320 in each row is located on the same arc line, and the center (i.e., the center of the circle) of each electrode unit 320 in the first row is defined as being located on the arc line H1, the center (i.e., the center of the circle) of each electrode unit 320 in the second row is located on the arc line H2, the center (i.e., the center of the circle) of each electrode unit 320 in the third row is located on the arc line H3, and the center (i.e., the center of the circle) of each electrode unit 320 in the fourth row is located on the arc line H4. Arc H1 and arc H4 are symmetrical along the axis of the horizontal center line X2, and arc H2 and arc H3 are symmetrical along the axis of the horizontal center line X2; arcs H1, H2, H3, and H4 are symmetrically arranged along the vertical center line Y2; the ends of arcs H1 and H2 are upward, and the ends of arcs H3 and H4 are downward.

[0043] The electrode unit groups C1 and C2 are both arranged in an inclined shape relative to the horizontal center line X2 and symmetrically relative to the vertical center line Y2. The electrode unit group C1 is taken as an example for explanation. The angle a1 between the horizontal axis X1 of the electrode unit group C1 and the horizontal line is 8°-12°, preferably 10°; the center angle of the arc segment AB of the arc H1 of the electrode unit group C1 is 11°-21°, preferably 16°. In this embodiment, the radius of the circle where the arc H1 is located is approximately 192mm, the center angle corresponding to the arc H1 is approximately 36°, and the arc length of the arc H1 is approximately 121mm. In this embodiment, the horizontal line is parallel to the horizontal center line X2.

[0044] Electrode unit groups C3 and C5 are both arranged in an inclined state relative to the transverse center line X2 and are symmetrical relative to the vertical center line Y2. The electrode unit group C3 is taken as an example for explanation. The angle a2 between the transverse axis X1 of the electrode unit group C3 and the horizontal line is 8°-12°, preferably 10°; the arc segment DE of the electrode unit group C3 at the arc H2 has a corresponding center angle of 7-11°, preferably 9°. In this embodiment, the radius of the circle where the arc H2 is located is approximately 361mm, the center angle corresponding to the arc H2 is approximately 29°, and the arc length of the arc H2 is approximately 183mm. The electrode unit group C4 is arranged horizontally relative to the transverse center line X2 and is symmetrical along the vertical center line Y2.

[0045] Electrode unit group C9 and electrode unit group C1, electrode unit group C10 and electrode unit group C2 are all symmetrically arranged along the transverse center line X2, electrode unit group C6 and electrode unit group C3, electrode unit group C7 and electrode unit group C4, electrode unit group C8 and electrode unit group C5 are all symmetrically arranged along the transverse center line X2. For relevant arrangement methods, please refer to the relevant contents of electrode unit groups C1 to C5.

[0046] It can be understood that the arc lengths of arc segment AB and arc segment DE are close, but the central angle corresponding to arc segment AB is larger than the central angle corresponding to arc segment DE, that is, the curvature of arc H1 is greater than the curvature of arc H2, and arc H1 is more curved. The vertical distances between adjacent arcs H1, H2, H3 and H4 are basically the same, about 33-35 mm. The vertical distance between the center (i.e., the center of the circle) of an electrode unit 320 away from the vertical center line Y2 in the electrode unit group C1 and the center (i.e., the center of the circle) of an electrode unit 320 close to the vertical center line Y2 in the third electrode unit group C3 is d1, that is, the vertical distance between the centers (i.e., the centers of the circles) of the two electrode units 320 located in the first row and the second row and both located in the second column is d1, and d1 is about 38 mm. The vertical distance between the center (i.e., the center of the circle) of another electrode unit 320 in the electrode unit group C1 close to the vertical center line Y2 and the center (i.e., the center of the circle) of an electrode unit 320 in the fourth electrode unit group C4 close to it is d2, that is, the vertical distance between the centers (i.e., the centers of the circles) of the two electrode units 320 located in the first row and the second row and in the third column is d2, where d2 is less than d1, and d2 is about 35 mm. The horizontal dimension K1 of the gap between the electrode unit groups C1 and C2 is about 11.5 mm, and the horizontal dimension K2 of the gap between the electrode unit groups C3 and C4 is about 7.5 mm.

[0047] refer to Figure 8 and Fig. 9 As shown, Figure 8 is a second electrode array 42 of the second electrode patch 40, Fig. 9 It is a distribution diagram of the electrode unit group C' of the second electrode array 42. The other component structures of the second electrode patch 40 are similar to those of the first electrode patch 30 and will not be repeated. The second electrode array 42 also includes twenty electrode units 420 arranged in four rows and six columns, and the twenty electrode units 420 are numbered 1-20 from left to right and from top to bottom. These twenty electrode units 420 constitute ten electrode unit groups C', and the electrode unit groups C'1, C'2, C'3, C'5, C'6, C'8, C'9, and C'10 located at the outer edge of the second electrode patch 40 are also defined as peripheral electrode unit groups C', and the electrode unit groups C'4 and C'7 located at the center of the second electrode patch 40 are central electrode unit groups C'. The hierarchical structure of the second electrode array 42 is also the same as that of the first electrode array 32, and reference may be made to the aforementioned related content.

[0048] The second electrode array 42 is different from the first electrode array 32 only in that the ten electrode unit groups C'1-C'10 are all arranged horizontally and are symmetrically arranged along the horizontal center axis X3 and the vertical center axis Y3. At least a part of the perimeter of each peripheral electrode unit group C' constitutes the outer boundary N of the corresponding entire electrode array, and the part of the outer boundary N that overlaps with each peripheral electrode unit group C' does not exceed 10% of the perimeter of the peripheral electrode unit group C'. The center (i.e., the center of the circle) of the four electrode units 420 in the first row is located on the horizontal line L1, the center (i.e., the center of the circle) of the six electrode units 420 in the second row is located on the horizontal line L2, the center (i.e., the center of the circle) of the six electrode units 420 in the third row is located on the horizontal line L3, and the center (i.e., the center of the circle) of the four electrode units 420 in the fourth row is located on the horizontal line L4. The lengths of the straight lines L1 and L4 are approximately 126 mm, and the lengths of the straight lines L2 and L3 are approximately 198 mm. The spacings between adjacent straight lines L1, L2, L3, and L4 are equal, all d3, and are greater than the spacing d1 between two adjacent electrode units 420 in the first row and the second row and both in the second column in the first electrode array 32, d3 being approximately 44 mm. The horizontal dimension K3 of the gap between two adjacent electrode unit groups C' in each row is the same, being approximately 16 mm.

[0049] Ginseng Fig.10 As shown, it shows the specific distribution diagram of twenty electrode units of the electrode array in the electrode patch in the prior art. The spatial arrangement of these electrode units is similar to the arrangement of the electrode unit 420 in the second electrode array 42. The specific hierarchical structure of these electrode units is similar to the electrode units 320 and 420, which will not be repeated here. The difference is that in the prior art, these electrode units are independently set and the AC signal is applied separately.

[0050] In this application, Fig.10 The electrode array in the electrode patch in the prior art shown is used as a comparison electrode array and the first electrode array 32 and the second electrode array 42 to perform finite element simulation calculations to analyze the current density and current density uniformity of each electrode unit. Fig.11As shown, the current density of each electrode unit 320 of the first electrode array 32 is lower than the corresponding electrode unit 420 of the second electrode array 42, and the current density of the corresponding electrode unit 420 of the second electrode array 42 is lower than the corresponding electrode unit of the comparison electrode array. It can be seen that the density of each electrode unit 320, 420 in the current of the first electrode array 32 and the second electrode array 42 is lower, that is, the grouped arrangement of electrode units can effectively alleviate the generation of edge effects. Further comparing the first electrode array 32 and the second electrode array 42, the current density of each electrode unit in the two electrode arrays is different, among which the electrode units 320 (numbered 7, 8) in the first electrode array 32 have the largest current density reduction, about 27%, compared with the electrode units 420 (numbered 7, 8) in the second electrode array 42, that is, the current density of the first electrode array 32 of the first electrode patch 30 has a lower average value.

[0051] However, in terms of the current density uniformity of each electrode unit 320, the standard deviation of the first electrode array 32 is 4.8, and the standard deviation of the second electrode array 42 is 2.9, that is, the current density uniformity of the second electrode array 42 of the second electrode patch 40 is better.

[0052] Combined with the above calculation results, the current density flowing through each electrode unit 320 in the first electrode patch 30 is relatively low, while the current density flowing through each electrode unit 420 in the second electrode patch 40 has better uniformity, and the combined use effect is better. Specifically, in areas where the skin position is relatively flat, such as the front and back sides of the human body, and the equivalent resistance of the human body in this area is also relatively uniform, the second electrode patch 40 can be used; and in areas where the skin structure is relatively undulating and prone to large deformation, such as the armpits and the left and right sides of the human body, the first electrode patch 30 can be used with the help of the specific changes in the equivalent resistance of the human body with the shape of the human body part (the equivalent resistance in the armpit area is relatively large, and the distance becomes shorter and the equivalent resistance becomes smaller after the edge of the first electrode array 32 extends to two sides), and the arc length and curvature of the arc H1, H2, H3 and H4 of the first electrode array 32 are differentially set, and the compensation design is carried out according to the electrical parameters of the human body. At the same time, it is used in combination with the second electrode patch 40 to improve the uniformity of the overall current density and the effectiveness of the electric field transmission, so as to maximize the benefit of the patient.

[0053] The above is only a preferred implementation mode of the present application and is not intended to limit the present application. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. A tumor electric field treatment system, comprising an electric field generator and a plurality of electrode patches arranged in pairs, characterized in that: The plurality of pairs of electrode patches include a pair of first electrode patches and a pair of second electrode patches, the first electrode patches and the second electrode patches are each provided with a plurality of electrode units, and the plurality of electrode units are arranged in a plurality of rows and columns, wherein the centers of the plurality of electrode units in the same row of the first electrode patches are on the same arc line, and the centers of the plurality of electrode units in the same row of the second electrode patches are on the same horizontal line.

2. The tumor electric field treatment system according to claim 1, characterized in that: The first electrode patch and the second electrode patch are provided with a plurality of electrode units of the same number, and the plurality of electrode units of the first electrode patch and the second electrode patch are symmetrically arranged along a horizontal center line and a vertical center line respectively; in the first electrode patch, the two ends of the arc where the electrode units located on the upper side of the horizontal center line are located are arranged in an upward shape, and the two ends of the arc where the electrode units located on the lower side of the horizontal center line are located are arranged in a downward pressed shape.

3. The tumor electric field treatment system according to claim 2, characterized in that: The first electrode patch and the second electrode patch each include twenty electrode units distributed in four rows and six columns, and two adjacent electrode units and a connecting portion between the two electrode units constitute an electrode unit group, wherein the first row and the fourth row are respectively provided with two electrode unit groups, and the third row and the fourth row are respectively provided with three electrode unit groups, and the electrode units are provided with a dielectric layer, and the dielectric layers of the two electrode units in the electrode unit group also cover the connecting portion between the two electrode units and are continuously arranged.

4. The tumor electric field treatment system according to claim 3, characterized in that: In the first electrode patch, the electrode unit group located between the second row and the third row is arranged horizontally, and the other electrode unit groups are arranged obliquely. The angle between the line connecting the centers of the two electrode units of the inclined electrode unit group and the horizontal line is 8°-12°.

5. The tumor electric field treatment system according to claim 4, characterized in that: The diameter of the electrode unit is 18 mm-22 mm, and the center distance between two electrode units in the electrode unit group is 32 mm-35 mm.

6. The tumor electric field treatment system according to claim 5, characterized in that: The arcs where the centers of the electrode units in each of the electrode unit groups in the first to fourth rows of the first electrode patch are located are H1, H2, H3 and H4 respectively, wherein the curvature of arc H1 is greater than the curvature of arc H2, and the curvature of arc H4 is greater than the curvature of arc H3.

7. The tumor electric field treatment system according to claim 6, characterized in that: The center angle of the arc segment occupied by the electrode unit group on the arc H1 is 11°-21°.

8. The tumor electric field treatment system according to claim 7, characterized in that: The center angle of the arc segment occupied by the electrode unit group on the arc H2 is 7°-11°.

9. The tumor electric field treatment system according to claim 1, characterized in that: The horizontal lines where the centers of the electrode units in each of the electrode unit groups in the first to fourth rows of the second electrode patch are located are L1, L2, L3 and L4 respectively, and the vertical distance between adjacent horizontal lines is greater than the vertical distance between two of the electrode units in the first electrode patch which are located in the second column and respectively in the first and second rows.

10. The tumor electric field treatment system according to claim 1, characterized in that: The horizontal distance between the two electrode unit groups in the first row of the first electrode patch is greater than the horizontal distance between the two electrode unit groups in the second row of the first electrode patch; A horizontal distance between two electrode unit groups in the same row of the second electrode patch is greater than a horizontal distance between two electrode unit groups in the first row of the first electrode patch.

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