Heparin sodium precipitation separation device

Abstract

One or more embodiments of the invention provide a heparin sodium precipitation separation device, which is characterized in that by monitoring the pressure in a pressure cavity, a controller compares the pressure measured by a pressure sensor with a threshold pressure, if the measured pressure is greater than or equal to the threshold pressure, a scraping assembly is controlled to execute a scraping action, and a scraping plate moves upwards under the action of the pressure in a filter cavity, so that the heparin sodium is separated from the filter cavity. In the process of driving the lower butt-joint cylinder to move upwards, butting the staggered upper butt-joint port and lower butt-joint port and moving the scraping assembly downwards, the ultrafiltration element is located at the butt-joint position of the upper butt-joint port and the lower butt-joint port, liquid in the ultrafiltration element seeps reversely, micropores are flushed from the inside to the outside, and blockage caused by the fact that sediments are squeezed into the micropores by a scraping plate is avoided. According to the micro-pore cleaning device, the filtering speed can be monitored, the scraping action can be performed at a proper time, and meanwhile, reverse seepage washing can be performed on micro-pore blockage caused by scraping of the scraping plate, so that the micro-pore cleaning effect is further improved.

Description

Technical Field

[0001] One or more embodiments of the present specification relate to the technical field of sodium heparin separation, and in particular, to a sodium heparin precipitation and separation device. Background Art

[0002] Heparin sodium is a natural anticoagulant drug with extensive medicinal value and is widely used in the medical field. Heparin sodium was originally extracted from animal tissues, and common sources include pig small intestinal mucosa, cow lungs, etc. The traditional extraction process mainly includes tissue homogenization, enzymatic hydrolysis, ion exchange adsorption, elution and other steps.

[0003] The existing sodium heparin extraction process usually uses precipitation separation technology. The Chinese invention patent with publication number CN118577129A discloses a sodium heparin precipitation separation device, which is provided with a water outlet at the upper end of the body, a cylindrical cavity at the inner wall of the body, an ultrafiltration element is arranged in the body, one end of the ultrafiltration element is fixedly connected to the lower end of the body, and the other end is fixedly connected to a partition, the partition is fixedly connected to the body, and a scraper is arranged so that the scraper slides up and down in the body. The scraper can scrape off the sodium heparin precipitate attached to the surface of the ultrafiltration element to prevent the sodium heparin precipitate from clogging the micropores of the ultrafiltration element, so as to improve the filtering effect of the ultrafiltration element.

[0004] However, the applicant has found that the prior art has at least the following problems:

[0005] During the scraping process, fine sediment comes into contact with the scraper. Although most of it is scraped off, a small part will be squeezed into the micropores, causing blockage of the micropores. Over time, the filtration efficiency of the ultrafiltration element will be reduced and the filtration effect will be reduced. Summary of the invention

[0006] In view of this, the purpose of one or more embodiments of this specification is to provide a sodium heparin precipitation separation device to solve the problem that a small portion of sodium heparin precipitation is squeezed into the micropores of the ultrafiltration element, resulting in reduced filtration effect.

[0007] 2. Based on the above purpose, one or more embodiments of the present specification provide a sodium heparin precipitation and separation device, including a cylinder, a cylinder cover is provided on the top of the cylinder, a water outlet is provided on the cylinder cover, a partition plate is provided below the cylinder cover, a cylinder bottom plate is provided at the bottom of the cylinder, a filter cavity is provided between the partition plate and the cylinder bottom plate, a plurality of ultrafilter elements are arranged in an array inside the filter cavity, the top outlet of the ultrafilter element extends between the partition plate and the cylinder cover, and is used to discharge the filtered liquid from the water outlet, a feed pipe is provided on the side wall of the cylinder, and is used to introduce the raw material to be separated into the filter cavity, and a sediment outlet is provided on the cylinder bottom plate, and is used to discharge the sediment, including:

[0008] The filter chamber is provided with a scraper assembly that can move up and down, and the scraper assembly includes a scraper cylinder adapted to be installed with the inner wall of the filter chamber, a scraper top plate is fixedly installed on the top of the scraper cylinder, a bellows is arranged between the scraper top plate and the partition plate, the bellows is adapted to be arranged on the outer periphery of the ultrafiltration element, a scraper bottom plate is fixedly installed inside the scraper cylinder, a liquid storage cavity is arranged between the scraper top plate and the scraper bottom plate, a scraper is installed below the scraper bottom plate, a pressure cavity is arranged between the scraper and the scraper bottom plate, a plurality of lower docking cylinders are arranged on the scraper bottom plate, the lower docking cylinders extend upward into the liquid storage cavity, an upper docking cylinder adapted to the lower docking cylinder is installed on the scraper top plate, An upper docking sleeve is provided with an upper docking interface, and a lower docking sleeve is provided with a lower docking interface. Under normal circumstances, the upper docking interface and the lower docking interface are misaligned, and the upper docking sleeve cooperates with the lower docking sleeve to seal and wrap the part of the ultrafiltration element passing through the scraping assembly; a pressure sensor is installed in the pressure chamber, and the pressure sensor signal is connected to a controller. A threshold pressure is preset in the controller. When the pressure of the pressure sensor is ≥ the threshold pressure, the scraping assembly is controlled to perform the scraping action and the feed pipeline is closed. The pressure sensor is used to monitor the pressure change when the scraping assembly moves downward, and to regulate the downward movement speed; the pressure chamber is also connected to an air pump for regulating the pressure in the pressure chamber.

[0009] Optionally, a liquid level sensor is installed in the liquid storage chamber to monitor the liquid level in the liquid storage chamber. A regulating valve is installed in the water outlet. The controller reads the liquid level sensor information. If the liquid level in the liquid storage chamber does not rise when the scraping action is performed, the water outlet speed is reduced. Otherwise, the liquid level sensor information is read repeatedly. The liquid storage chamber is also connected to a drainage pump to discharge the liquid inside the liquid storage chamber after the scraping action is completed.

[0010] Optionally, the lower docking cylinder is connected to the scraping bottom plate and the scraper plate by a sealed bearing for the rotation of the lower docking cylinder, and a vertical slide groove and a sliding block that cooperate with each other are arranged between the upper docking cylinder and the lower docking cylinder, and the upper docking cylinder can be rotatably installed on the scraping top plate, and a driven gear is sleeved on the circumferential side of the upper docking cylinder, and the driven gear is meshedly connected with a gear ring, and a mounting sleeve adapted to the gear ring is installed under the scraping top plate, and a helical gear ring is fixedly installed on the bottom surface of the gear ring, and the helical gear ring is meshedly connected with a bevel gear, and the bevel gear is connected to a transmission shaft, and a sealed protective shell is provided on the side of the cylinder body, and a rack is vertically installed in the protective shell, and the transmission shaft extends from the liquid storage chamber to the protective shell, and a transmission gear is connected to the end of the transmission shaft, and the transmission gear is meshed with the rack, and an avoidance groove for the transmission shaft to move up and down is opened between the protective shell and the cylinder body.

[0011] Optionally, a vertical guide cylinder is installed on the scraping base plate, a sealed bearing is installed between the vertical guide cylinder and the scraping base plate, a vertical guide groove is opened on the inner wall of the vertical guide cylinder, and a vertical guide block adapted to the vertical guide groove is installed on the side wall of the lower docking cylinder.

[0012] Optionally, a transmission shell is installed on the side wall of the cylinder, a transmission screw is installed in the transmission shell, the transmission screw extends upward from the transmission shell and is dynamically connected to a screw motor, a screw slider is adapted to be installed on the transmission screw, and the screw slider is fixedly connected to the outer periphery of the scraper cylinder.

[0013] Optionally, the upper end of the feed pipe includes a water inlet connected to a water pump, and the lower end of the feed pipe is provided with an input port leading to the bottom of the filter chamber.

[0014] Optionally, the bottom plate of the cylinder has an inclined surface converging toward the sediment outlet for converging the sediment.

[0015] Optionally, a sealing assembly is provided below the sediment outlet, a resistance rod is installed on the bottom surface of the scraper, a slope is provided at the bottom end of the resistance rod, the sealing assembly includes a sealing plug for blocking the sediment outlet, the sealing plug includes an inclined top surface on the upper surface, the inclined top surface is adapted to the slope at the bottom end of the resistance rod, and is used to drive the sealing plug to move horizontally when resistance is received, thereby unblocking the sediment outlet.

[0016] Optionally, the side of the sealing plug is provided with an inclined slope, which enables the sealing plug to expand to both sides from front to back respectively, the front end of the sealing plug is connected to a columnar block, the rear end of the sealing plug is connected to a vertical slide, the vertical slide is lowered and fixedly connected to a transverse support plate, a return spring is connected between the transverse support plate and the sealing plug, a retreat groove adapted to the sealing plug is provided below the sediment outlet, which is used for the sealing plug to retreat when the resistance rod squeezes the sealing plug, the end of the retreat groove is provided with a columnar block adapted to the columnar block, and the retreat A sinking groove matched with the sealing plug is provided below the groove, and the sinking groove is used for the sealing plug to retreat to the point where the column-shaped card block exits the column-shaped card hole and sinks. A horizontal groove is connected to the retreat groove and the rear of the sinking groove, and the horizontal groove is matched with the vertical slide seat. An elastic rod is connected between the vertical slide seat and the horizontal groove, and is used to keep the column-shaped card block in the column-shaped card hole under normal circumstances. A flow hole is provided at the front end of the sinking groove, and the aperture of the flow hole is larger than the diameter of the column-shaped card block. An external interface is provided below the flow hole, and the external interface is closed by a horizontal support plate under normal circumstances.

[0017] Optionally, a T-shaped slider is installed on the sealing plug, and a T-shaped slot matching the T-shaped slider is opened on the vertical sliding seat.

[0018] From the above description, it can be seen that a sodium heparin precipitation and separation device provided by one or more embodiments of the present specification monitors the pressure in the pressure chamber. When the filtration speed decreases due to the attachment of sediment to the ultrafiltration element, the water outlet speed decreases while maintaining the feed speed, and the pressure in the pressure chamber increases. The pressure sensor sends a signal to the controller, and the controller compares the pressure measured by the pressure sensor with the threshold pressure. If the measured pressure is greater than or equal to the threshold pressure, the scraper assembly is controlled to perform a scraping action. Under the pressure in the filter chamber, the scraper moves up, driving the lower docking tube to move up, and docking the dislocated upper docking interface with the lower docking interface. During the downward movement of the scraper assembly, the pressure sensor monitors the pressure change in the pressure chamber, thereby regulating the downward movement speed of the scraper assembly to avoid moving down too fast, resulting in excessive pressure in the filter chamber. During the downward movement of the scraper assembly, the ultrafiltration element is at the docking position between the upper docking interface and the lower docking interface, and the internal liquid seeps out in the reverse direction to flush the micropores from the inside to the outside, thereby avoiding blockage caused by the scraper squeezing the sediment into the micropores. It can monitor the filtration speed and perform scraping at the right time. At the same time, it can reversely wash the micropores blocked by scraping, further improving the micropore cleaning effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate one or more embodiments of the present specification or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only one or more embodiments of the present specification. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0020] Figure 1 A schematic diagram of a sodium heparin precipitation and separation device according to one or more embodiments of this specification;

[0021] Figure 2 This is an internal schematic diagram of a sodium heparin precipitation and separation device according to one or more embodiments of this specification;

[0022] Figure 3 for Figure 2 A schematic diagram of the enlarged local structure of part A;

[0023] Figure 4 A schematic diagram of a scraping component of a sodium heparin precipitation and separation device according to one or more embodiments of this specification;

[0024] Figure 5 A schematic diagram of a discharge port of a sodium heparin precipitation and separation device according to one or more embodiments of this specification Figure 1 ;

[0025] Figure 6 for Figure 5A schematic diagram of the enlarged local structure of part B;

[0026] Figure 7 The working status of the plugging component is shown in Figure 1. Figure 1 ;

[0027] Figure 8 The working status of the plugging component is shown in Figure 1. Figure 2 ;

[0028] Fig. 9 is a schematic diagram of the structure of the plugging component;

[0029] Fig.10 A schematic diagram of a discharge port of a sodium heparin precipitation and separation device according to one or more embodiments of this specification Figure 2 ;

[0030] Fig.11 for Fig.10 A magnified schematic diagram of the local structure of part C in the middle;

[0031] Fig.12 It is a side sectional view of the lower docking tube.

[0032] In the figure:

[0033] 101, cylinder; 102, cylinder cover; 103, water outlet; 104, water inlet; 105, feed pipe; 106, input port; 107, filter chamber; 108, partition plate; 109, ultrafiltration element; 110, cylinder bottom plate; 111, support frame; 201, scraper cylinder; 202, scraper top plate; 203, scraper bottom plate; 2031, vertical guide cylinder; 2032, vertical guide groove; 2033, vertical guide block; 204, upper docking cylinder; 2041, upper docking interface; 205, lower docking cylinder; 2051, lower docking interface; 206, gear ring; 207, helical gear ring; 208, driven gear; 209, Scraper; 301, transmission shaft; 302, bevel gear; 304, transmission gear; 305, protective shell; 306, rack; 401, screw motor; 402, transmission screw; 403, screw slider; 501, sediment outlet; 502, sealing plug; 5021, inclined slope; 5022, inclined top surface; 503, columnar block; 504, T-slider; 505, vertical slide; 506, elastic rod; 507, T-slot; 508, horizontal support plate; 509, columnar hole; 510, external interface; 511, flow hole; 512, sinking groove; 513, retreat groove; 514, horizontal groove. DETAILED DESCRIPTION

[0034] In order to make the objectives, technical solutions and advantages of the present disclosure more clearly understood, the present disclosure is further described in detail below in conjunction with specific embodiments.

[0035] It should be noted that, unless otherwise defined, the technical terms or scientific terms used in one or more embodiments of this specification should be understood by people with ordinary skills in the field to which this disclosure belongs. The "first", "second" and similar words used in one or more embodiments of this specification do not indicate any order, quantity or importance, but are only used to distinguish different components. "Include" or "comprise" and similar words mean that the elements or objects appearing before the word cover the elements or objects listed after the word and their equivalents, without excluding other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0036] One or more embodiments of this specification provide a sodium heparin precipitation and separation device, such as Figures 1 to 4 As shown, it includes a cylinder 101, a cylinder cover 102 is arranged on the top of the cylinder 101, a water outlet 103 is arranged on the cylinder cover 102, a partition plate 108 is arranged below the cylinder cover 102, a cylinder bottom plate 110 is arranged at the bottom of the cylinder 101, a filter chamber 107 is arranged between the partition plate 108 and the cylinder bottom plate 110, a plurality of ultrafiltration elements 109 are arranged in an array inside the filter chamber 107, and the top outlet of the ultrafiltration element 109 extends between the partition plate 108 and the cylinder cover 102, which is used to discharge the filtered liquid from the water outlet 103, a feed pipe 105 is arranged on the side wall of the cylinder 101, which is used to introduce the raw materials to be separated into the filter chamber 107, and a sediment outlet 501 is opened on the cylinder bottom plate 110, which is used to discharge the sediment;

[0037] The filter chamber 107 is provided with a scraper assembly that can move up and down, and the scraper assembly includes a scraper cylinder 201 adapted to be installed with the inner wall of the filter chamber 107, a scraper top plate 202 is fixedly installed on the top of the scraper cylinder 201, a bellows is arranged between the scraper top plate 202 and the partition plate 108, and the bellows is adapted to be arranged on the outer periphery of the ultrafiltration element 109, a scraper bottom plate 203 is fixedly installed inside the scraper cylinder 201, a liquid storage cavity is arranged between the scraper top plate 202 and the scraper bottom plate 203, a scraper 209 is installed below the scraper bottom plate 203, and the scraper 209 and the scraper A pressure chamber is provided between the bottom plates 203, a plurality of lower docking tubes 205 are provided on the scraping bottom plate 203, the lower docking tubes 205 extend upward into the liquid storage chamber, an upper docking tube 204 adapted to the lower docking tube 205 is installed on the scraping top plate 202, an upper docking tube 204 is provided with an upper docking port 2041, and a lower docking tube 205 is provided with a lower docking port 2051. Under normal conditions, the upper docking port 2041 is misaligned with the lower docking port 2051, and the upper docking tube 204 cooperates with the lower docking tube 205 to seal and wrap the ultrafiltration element 109 passing through the scraping assembly;

[0038] A pressure sensor is installed in the pressure chamber, and the pressure sensor signal is connected to a controller. A threshold pressure is preset in the controller. When the pressure of the pressure sensor is ≥ the threshold pressure, the scraping component is controlled to perform the scraping action and the feed pipe 105 is closed. The pressure sensor is used to monitor the pressure change when the scraping component moves downward and regulate the downward movement speed; the pressure chamber is also connected to an air pump for regulating the pressure in the pressure chamber.

[0039] During sedimentation separation, the mixed raw material is introduced into the filter chamber 107 from the feed pipe 105. As the mixed liquid in the filter chamber 107 gradually increases and fills up, the pressure in the filter chamber 107 gradually increases, and the pressure on the scraper 209 also gradually increases. By monitoring the pressure in the pressure chamber, the feed speed of the feed pipe 105 is regulated so that the filtration speed and the feed speed are kept in dynamic balance. Then, the raw material is input into the feed pipe 105 at a certain speed, and the raw material is filtered by the ultrafiltration element 109. The liquid goes upward into the space between the partition plate 108 and the cylinder cover 102, and is discharged through the water outlet 103. When the filtration speed decreases due to the attachment of sediment to the ultrafiltration element 109, the water outlet speed decreases while maintaining the feed speed, and the pressure in the pressure chamber increases. The pressure sensor sends a signal to the controller, and the controller compares the pressure measured by the pressure sensor with the threshold pressure. Yes, if the measured pressure is ≥ the threshold pressure, the scraping component is controlled to perform the scraping action, otherwise the pressure data of the pressure sensor is repeatedly received. When the scraping action is performed, the scraping component is driven to move downward. At the same time, the air pump reduces the pressure in the pressure chamber. Under the pressure in the filter chamber 107, the scraper 209 moves upward, driving the lower docking tube 205 to move upward, and docking the dislocated upper docking port 2041 with the lower docking port 2051. During the downward movement of the scraping component, the pressure sensor monitors the pressure change in the pressure chamber, thereby regulating the downward movement speed of the scraping component to avoid moving downward too quickly, resulting in excessive pressure in the filter chamber 107. During the downward movement of the scraping component, the ultrafiltration element 109 is in the docking position between the upper docking port 2041 and the lower docking port 2051, and the internal liquid seeps out in the opposite direction, flushing the micropores from the inside to the outside, avoiding blockage caused by the scraper 209 squeezing the sediment into the micropores, and the seeped liquid is stored in the liquid storage chamber. The filtering speed can be monitored and scraping can be performed at an appropriate time. At the same time, the micropores blocked by the scraper 209 can be reversely washed to further improve the micropore cleaning effect.

[0040] In some optional specific embodiments, a liquid level sensor is installed in the liquid storage chamber to monitor the liquid level in the liquid storage chamber. A regulating valve is installed in the water outlet 103. The controller reads the liquid level sensor information. If the liquid level in the liquid storage chamber does not rise when the scraping action is performed, the speed of the water outlet 103 is reduced. Otherwise, the liquid level sensor information is read repeatedly. The liquid storage chamber is also connected to a drainage pump to discharge the liquid inside the liquid storage chamber after the scraping action is completed.

[0041] In some optional specific embodiments, such as Figures 1 to 4As shown, the lower docking tube 205 is connected to the scraping bottom plate 203 and the scraping plate 209 through a sealed bearing for the rotation of the lower docking tube 205. The upper docking tube 204 and the lower docking tube 205 are provided with a vertical slide groove and a slider that cooperate with each other. The upper docking tube 204 can be rotatably installed on the scraping top plate 202. The upper docking tube 204 is sleeved with a driven gear 208 on the circumference. The driven gear 208 is meshed and connected with a gear ring 206. A mounting sleeve adapted to the gear ring 206 is installed below the scraping top plate 202. The bottom surface of the gear ring 206 A bevel gear ring 207 is fixedly installed, the bevel gear ring 207 is meshedly connected with a bevel gear 302, the bevel gear 302 is connected with a transmission shaft 301, a sealed protective shell 305 is provided on the side of the cylinder 101, a rack 306 is vertically installed in the protective shell 305, the transmission shaft 301 extends from the liquid storage cavity to the protective shell 305, the end of the transmission shaft 301 is connected with a transmission gear 304, the transmission gear 304 is meshed with the rack 306, and an avoidance groove for the transmission shaft 301 to move up and down is provided between the protective shell 305 and the cylinder 101.

[0042] During use, the scraper assembly moves downward, the transmission gear 304 meshes with the rack 306 for transmission, thereby driving the transmission shaft 301 to rotate, the transmission shaft 301 drives the bevel gear 302 to rotate, the bevel gear 302 meshes with the transmission helical gear ring 207 to rotate, thereby driving the gear ring 206 to rotate in the installation sleeve, the gear ring 206 meshes with the transmission driven gear 208, thereby driving the multiple upper docking cylinders 204 to rotate, the upper docking cylinder 204 and the lower docking cylinder 205 are provided with mutually cooperating vertical slide grooves and sliders, so that they cannot rotate relative to each other, but can only move up and down relative to each other, thereby driving the lower docking cylinder 205 to rotate, driving the docking point of the upper docking port 2041 and the lower docking port 2051 to rotate, so that the surrounding side of the ultrafiltration element 109 can be reversely infiltrated without leaving dead angles.

[0043] In some optional specific embodiments, such as Fig.12 As shown, a vertical guide cylinder 2031 is installed on the scraping bottom plate 203, a sealed bearing is installed between the vertical guide cylinder 2031 and the scraping bottom plate 203, a vertical guide groove 2032 is opened on the inner wall of the vertical guide cylinder 2031, and a vertical guide block 2033 adapted to the vertical guide groove 2032 is installed on the side wall of the lower docking cylinder 205, so as to realize the up and down movement and rotation movement of the lower docking cylinder 205.

[0044] In some optional specific embodiments, such as Figures 1 to 4 As shown, a transmission housing is installed on the side wall of the cylinder 101, a transmission screw 402 is installed in the transmission housing, the transmission screw 402 extends upward from the transmission housing and is connected to the screw motor 401, a screw slider 403 is installed on the transmission screw 402, and the screw slider 403 is fixedly connected to the outer periphery of the scraping cylinder 201, which is used to drive the scraping assembly to move up and down.

[0045] In some optional specific embodiments, such as Figures 1 to 4 As shown, the upper end of the feed pipe 105 includes a water inlet 104 connected to a water pump, and the lower end of the feed pipe 105 is provided with an input port 106 leading to the bottom of the filter chamber 107 .

[0046] In some optional specific embodiments, such as Figures 5 to 11 As shown, the cylinder bottom plate 110 has an inclined surface converging toward the sediment outlet 501 for converging the sediment.

[0047] In some optional specific embodiments, such as Figures 5 to 11 As shown, a blocking assembly is provided below the sediment outlet 501, a resistance rod is installed on the bottom surface of the scraper 209, and a slope is provided at the bottom end of the resistance rod. The blocking assembly includes a blocking plug 502 for blocking the sediment outlet 501, and the sealing plug 502 includes an inclined top surface 5022 on the upper surface, and the inclined top surface 5022 is adapted to the inclined surface at the bottom end of the resistance rod, and is used to drive the sealing plug 502 to move horizontally when receiving resistance, so as to release the blockage of the sediment outlet 501.

[0048] In some optional specific embodiments, such as Figures 5 to 11 As shown, the side of the sealing plug 502 is provided with an inclined surface 5021, and the inclined surface 5021 makes the sealing plug 502 expand to both sides from front to back respectively, the front end of the sealing plug 502 is connected to a columnar block 503, and the rear end of the sealing plug 502 is connected to a vertical slide seat 505, and the vertical slide seat 505 is lowered and fixedly connected with a horizontal support plate 508, and a return spring is connected between the horizontal support plate 508 and the sealing plug 502, and a retreat groove 513 adapted to the sealing plug 502 is provided below the sediment outlet 501, which is used for the sealing plug 502 to retreat when the resistance rod squeezes the sealing plug 502, and the end of the retreat groove 513 is provided with a columnar card hole 509 adapted to the columnar block 503, and the retreat groove 513 is provided with a The sealing plug 502 is matched with a sinking groove 512, and the sinking groove 512 is used for the sealing plug 502 to sink when it retreats to the point where the columnar block 503 exits the columnar hole 509. The retreat groove 513 is connected to the sinking groove 512 at the rear with a horizontal groove 514, and the horizontal groove 514 is matched with the vertical slide 505. An elastic rod 506 is connected between the vertical slide 505 and the horizontal groove 514, and is used to keep the columnar block 503 in the columnar hole 509 under normal circumstances. A flow hole 511 is provided at the front end of the sinking groove 512, and the aperture of the flow hole 511 is larger than the diameter of the columnar block 503. An external interface 510 is provided below the flow hole 511, and the external interface 510 is closed by the horizontal support plate 508 under normal circumstances.

[0049] During use, when receiving resistance, the resistance rod drives the sealing plug 502 to move horizontally, so that the columnar block 503 moves out of the columnar hole 509, and the elastic rod 506 is compressed. At this time, the sealing plug 502 is located above the sinking groove 512. If the squeezing continues, the sealing plug 502 moves downward along the vertical slide seat 505. At this time, the columnar block 503 is in the flow hole 511. Since the sealing plug 502 has an inclined top surface 5022, the sediment moves from the inclined top surface 5022 to the flow hole 511 and flows downward from the external interface 510. It should be pointed out that the size of the resistance rod is smaller than the inner diameter of the sediment outlet 501.

[0050] In some optional specific embodiments, such as Fig. 9 As shown, a T-shaped slider 504 is installed on the sealing plug 502 , and a T-shaped slot 507 matched with the T-shaped slider 504 is opened on the vertical sliding seat 505 .

[0051] In some optional specific embodiments, a plurality of support frames 111 are installed at the bottom of the cylinder bottom plate 110 .

[0052] Working principle of the present invention: when performing sedimentation separation, the mixed raw material is introduced into the filter chamber 107 from the feed pipe 105. As the mixed liquid in the filter chamber 107 gradually increases and fills up, the pressure in the filter chamber 107 gradually increases, and the pressure on the scraper 209 also gradually increases. By monitoring the pressure in the pressure chamber, the feed speed of the feed pipe 105 is regulated so that the filtration speed and the feed speed are kept in dynamic balance. Then, the raw material is input into the feed pipe 105 at a certain speed, and the raw material is filtered by the ultrafiltration element 109. The liquid goes upward into the space between the partition plate 108 and the cylinder cover 102, and is discharged through the water outlet 103. When the filtration speed decreases due to the attachment of sediment to the ultrafiltration element 109, the water outlet speed decreases while maintaining the feed speed, and the pressure in the pressure chamber increases. The pressure sensor sends a signal to the controller, and the controller compares the pressure measured by the pressure sensor with the threshold value The pressure is compared. If the measured pressure is ≥ the threshold pressure, the scraping component is controlled to perform the scraping action, otherwise the pressure data of the pressure sensor is repeatedly received. When the scraping action is performed, the scraping component is driven to move downward. At the same time, the air pump reduces the pressure in the pressure chamber. Under the pressure in the filter chamber 107, the scraper 209 moves upward, driving the lower docking tube 205 to move upward, and docking the dislocated upper docking port 2041 with the lower docking port 2051. During the downward movement of the scraping component, the pressure sensor monitors the pressure change in the pressure chamber, thereby regulating the downward movement speed of the scraping component to avoid moving down too fast and causing excessive pressure in the filter chamber 107. During the downward movement of the scraping component, the ultrafiltration element 109 is at the docking position between the upper docking port 2041 and the lower docking port 2051, and the internal liquid seeps out in the opposite direction to flush the micropores from the inside to the outside, avoiding blockage caused by the scraper 209 squeezing the sediment into the micropores, and the seeped liquid is stored in the liquid storage chamber. The filtering speed can be monitored and scraping can be performed at an appropriate time. At the same time, the micropores blocked by the scraper 209 can be reversely washed to further improve the micropore cleaning effect.

[0053] At the same time, when receiving the resistance, the resistance rod drives the sealing plug 502 to move horizontally, so that the columnar block 503 moves out of the columnar hole 509, and the elastic rod 506 is compressed. At this time, the sealing plug 502 is located above the sinking groove 512. If the squeezing continues, the sealing plug 502 moves downward along the vertical slide seat 505. At this time, the columnar block 503 is in the flow hole 511. Since the sealing plug 502 has an inclined top surface 5022, the sediment moves from the inclined top surface 5022 to the flow hole 511 and flows downward from the external interface 510. It should be pointed out that the size of the resistance rod is smaller than the inner diameter of the sediment outlet 501.

[0054] Those skilled in the art should understand that the discussion of any of the above embodiments is merely illustrative and is not intended to imply that the scope of the present disclosure (including the claims) is limited to these examples. In line with the present disclosure, the technical features in the above embodiments or different embodiments may be combined, the steps may be implemented in any order, and there are many other variations of different aspects of one or more embodiments of the present specification as described above, which are not provided in detail for the sake of simplicity.

[0055] In addition, to simplify the description and discussion, and in order not to obscure one or more embodiments of the present specification, known power / ground connections to integrated circuit (IC) chips and other components may or may not be shown in the provided figures. In addition, the device may be shown in the form of a block diagram so as to avoid obscuring one or more embodiments of the present specification, and this also takes into account the fact that the details of the implementation of these block diagram devices are highly dependent on the platform on which one or more embodiments of the present specification will be implemented (i.e., these details should be fully within the scope of understanding of those skilled in the art). Where specific details (e.g., circuits) are set forth to describe exemplary embodiments of the present disclosure, it is apparent to those skilled in the art that one or more embodiments of the present specification may be implemented without these specific details or with variations in these specific details. Therefore, these descriptions should be considered illustrative rather than restrictive.

[0056] Although the present disclosure has been described in conjunction with specific embodiments of the present disclosure, many replacements, modifications and variations of these embodiments will be apparent to those skilled in the art from the foregoing description. For example, other memory architectures (e.g., dynamic RAM (DRAM)) may use the embodiments discussed.

[0057] One or more embodiments of this specification are intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of one or more embodiments of this specification should be included in the scope of protection of this disclosure.

Claims

1. A heparin sodium precipitation and separation device, comprising a cylinder (101), a cylinder cover (102) is arranged on the top of the cylinder (101), a water outlet (103) is arranged on the cylinder cover (102), a partition plate (108) is arranged below the cylinder cover (102), a cylinder bottom plate (110) is arranged at the bottom of the cylinder (101), a filter cavity (107) is arranged between the partition plate (108) and the cylinder bottom plate (110), a plurality of ultrafiltration elements (109) are arranged in an array inside the filter cavity (107), the top outlet of the ultrafiltration element (109) extends between the partition plate (108) and the cylinder cover (102), a feed pipe (105) is arranged on the side wall of the cylinder (101), and a sediment outlet (501) is opened on the cylinder bottom plate (110), characterized in that: include: A scraping assembly that can move up and down is provided inside the filter chamber (107), and the scraping assembly includes a scraping cylinder (201) that is mounted on the inner wall of the filter chamber (107). A scraping top plate (202) is fixedly mounted on the top of the scraping cylinder (201), a bellows is arranged between the scraping top plate (202) and the partition plate (108), and the bellows is mounted on the outer periphery of the ultrafiltration element (109). A scraping bottom plate (203) is fixedly mounted inside the scraping cylinder (201), a liquid storage chamber is arranged between the scraping top plate (202) and the scraping bottom plate (203), a scraper (209) is installed below the scraping bottom plate (203), a pressure chamber is arranged between the scraper (209) and the scraping bottom plate (203), and a plurality of lower docking cylinders (205) are arranged on the scraping bottom plate (203), and the lower docking cylinders (205) extend upward to the liquid storage chamber. In the cavity, an upper docking sleeve (204) matched with a lower docking sleeve (205) is installed on the scraping top plate (202), an upper docking sleeve (204) is provided with an upper docking port (2041), and a lower docking sleeve (2051) is provided on the lower docking sleeve (205). Under normal conditions, the upper docking sleeve (204) cooperates with the lower docking sleeve (205) to seal and wrap the part of the ultrafiltration element (109) passing through the scraping assembly; a pressure sensor is installed in the pressure cavity, and the pressure sensor signal is connected to a controller. A threshold pressure is preset in the controller. When the pressure of the pressure sensor is ≥ the threshold pressure, the scraping assembly is controlled to perform a scraping action and the feed pipe (105) is closed. The pressure sensor is used to monitor the pressure change when the scraping assembly moves downward and to adjust the downward movement speed; the pressure cavity is also connected to an air pump for adjusting the pressure in the pressure cavity.

2. A heparin sodium precipitation and separation device according to claim 1, characterized in that: A liquid level sensor is installed in the liquid storage chamber for monitoring the liquid level in the liquid storage chamber. A regulating valve is installed in the water outlet (103). The controller reads the liquid level sensor information. If the liquid level in the liquid storage chamber does not rise when the scraping action is performed, the speed of the water outlet (103) is reduced. Otherwise, the liquid level sensor information is read repeatedly. The liquid storage chamber is also connected to a drainage pump for discharging the liquid in the liquid storage chamber after the scraping action is completed.

3. A heparin sodium precipitation and separation device according to claim 1, characterized in that: The lower docking tube (205) is connected to the scraping bottom plate (203) and the scraping plate (209) via a sealed bearing for the rotation of the lower docking tube (205); a vertical sliding groove and a sliding block that cooperate with each other are arranged between the upper docking tube (204) and the lower docking tube (205); the upper docking tube (204) is rotatably mounted on the scraping top plate (202); a driven gear (208) is sleeved on the circumference of the upper docking tube (204); the driven gear (208) is meshedly connected with a gear ring (206); a mounting sleeve adapted to the gear ring (206) is installed below the scraping top plate (202); the bottom surface of the gear ring (206) is fixedly mounted A helical gear ring (207) is provided, the helical gear ring (207) is meshedly connected with a bevel gear (302), the bevel gear (302) is connected with a transmission shaft (301), a sealed protective shell (305) is arranged on the side of the cylinder (101), a rack (306) is vertically installed in the protective shell (305), the transmission shaft (301) extends from the liquid storage cavity into the protective shell (305), the end of the transmission shaft (301) is connected with a transmission gear (304), the transmission gear (304) is meshedly connected with the rack (306), and an avoidance groove for the transmission shaft (301) to move up and down is provided between the protective shell (305) and the cylinder (101).

4. A heparin sodium precipitation and separation device according to claim 3, characterized in that: A vertical guide cylinder (2031) is installed on the scraping bottom plate (203), a sealed bearing is installed between the vertical guide cylinder (2031) and the scraping bottom plate (203), a vertical guide groove (2032) is opened on the inner wall of the vertical guide cylinder (2031), and a vertical guide block (2033) adapted to the vertical guide groove (2032) is installed on the side wall of the lower docking cylinder (205).

5. A heparin sodium precipitation and separation device according to claim 1, characterized in that: A transmission housing is installed on the side wall of the cylinder (101), a transmission screw (402) is installed in the transmission housing, the transmission screw (402) extends upward from the transmission housing and is motively connected to a screw motor (401), a screw slider (403) is adapted to be installed on the transmission screw (402), and the screw slider (403) is fixedly connected to the outer periphery of the scraping cylinder (201).

6. A heparin sodium precipitation and separation device according to claim 1, characterized in that: The upper end of the feed pipe (105) comprises a water inlet (104) connected to a water pump, and the lower end of the feed pipe (105) is provided with an input port (106) leading to the bottom of the filter chamber (107).

7. A heparin sodium precipitation and separation device according to claim 1, characterized in that: The cylinder bottom plate (110) has an inclined surface converging toward the sediment outlet (501) for converging the sediment.

8. The heparin sodium precipitation and separation device according to claim 1, characterized in that: A blocking assembly is provided below the sediment outlet (501), a resistance rod is installed on the bottom surface of the scraper (209), and a slope is provided at the bottom end of the resistance rod. The blocking assembly includes a blocking plug (502) for blocking the sediment outlet (501), and the sealing plug (502) includes an inclined top surface (5022) on the upper surface, and the inclined top surface (5022) is adapted to the inclined surface at the bottom end of the resistance rod, and is used to drive the sealing plug (502) to move horizontally when receiving resistance, so as to release the blockage of the sediment outlet (501).

9. A heparin sodium precipitation and separation device according to claim 8, characterized in that: The sealing plug (502) is provided with an inclined surface (5021) on the side, and the inclined surface (5021) makes the sealing plug (502) expand to both sides from the front to the back, respectively; the front end of the sealing plug (502) is connected with a columnar block (503), and the rear end of the sealing plug (502) is connected with a vertical slide seat (505); the vertical slide seat (505) is lowered and fixedly connected with a transverse support plate (508), and a return spring is connected between the transverse support plate (508) and the sealing plug (502); a retreat groove (513) adapted to the sealing plug (502) is provided below the sediment outlet (501) for retreating the sealing plug (502) when the resistance rod squeezes the sealing plug (502); the end of the retreat groove (513) is provided with a columnar block hole (509) adapted to the columnar block (503); the retreat groove (513) is provided with a columnar block hole (509) adapted to the columnar block (503) below the retreat groove (513); 02) is matched with a sinking groove (512), the sinking groove (512) is used for sinking when the sealing plug (502) retreats to the columnar clamping block (503) and exits the columnar clamping hole (509), the retreating groove (513) and the sinking groove (512) are connected to a horizontal groove (514) at the rear, the horizontal groove (514) is matched with the vertical slide seat (505), and the vertical slide seat (505) and the horizontal groove (514) are connected. An elastic rod (506) is connected to keep the columnar clamping block (503) in the columnar clamping hole (509) under normal conditions. A flow hole (511) is provided at the front end of the sinking groove (512). The diameter of the flow hole (511) is larger than the diameter of the columnar clamping block (503). An external interface (510) is provided below the flow hole (511). The external interface (510) is closed by a horizontal support plate (508) under normal conditions.

10. A heparin sodium precipitation and separation device according to claim 9, characterized in that: The sealing plug (502) is provided with a T-shaped slide block (504), and the vertical slide seat (505) is provided with a T-shaped groove (507) adapted to the T-shaped slide block (504).

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