Microneedle production equipment and microneedle production method

Abstract

The invention discloses microneedle production equipment and a microneedle production method.The microneedle production equipment comprises a mold, a bearing table, a first liquid spraying assembly, a second liquid spraying assembly and a position adjusting assembly, the mold is provided with a forming groove, and a plurality of needle holes are formed in the groove bottom of the forming groove; the bearing table is used for bearing a mold; the first liquid spraying assembly is arranged on the upper side of the bearing table, and the first liquid spraying assembly is used for injecting first material liquid into all the needle holes to form needle body parts of the microneedles; the second liquid spraying assembly is arranged on the upper side of the bearing table, and the second liquid spraying assembly is used for injecting second material liquid into the forming groove so as to form a backing part of the microneedle; the position adjusting assembly is in driving connection with the first liquid spraying assembly and the second liquid spraying assembly, and under adjustment of the position adjusting assembly, the first spraying head of the first liquid spraying assembly can be aligned with the needle hole or the second spraying head of the second liquid spraying assembly can be aligned with the forming groove. According to the invention, the microneedle with the needle body part and the backing part made of different materials can be manufactured.

Description

Technical Field

[0001] The present invention relates to the technical field of microneedle production, and in particular to a microneedle production device and a microneedle production method. Background Art

[0002] Microneedle technology is a new type of transdermal technology. It has been widely recognized in the medical field because of its advantages such as good patient compliance, strong controllability, and precise drug delivery. Microneedle substrates are usually composed of a needle body part and a backing part, and the material of the microneedle substrate is usually a biodegradable polymer material. Among them, the materials used for the needle body part and the backing part of the microneedle substrate on the market are usually integrally formed. However, since the needle body part of the microneedle substrate needs to penetrate the patient's skin, the selection and use of the material of the needle body part is more stringent, so the material cost of the needle body part is relatively high. If the backing part is made of the same material, the manufacturing cost of the microneedle substrate will be greatly increased. Summary of the invention

[0003] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the first aspect of the present invention provides a microneedle production device, which can manufacture microneedles whose needle body part and backing part are made of different materials.

[0004] The second aspect of the present invention also provides a microneedle production method.

[0005] A microneedle production device according to an embodiment of the first aspect of the present invention includes a mold, a carrier platform, a first spray component, a second spray component and a position adjustment component, the mold is provided with a molding groove, and a plurality of pinholes are opened at the bottom of the molding groove; the carrier platform is used to support the mold; the first spray component is arranged on the upper side of the carrier platform, and the first spray component is used to inject a first liquid into each pinhole to form a needle body part of the microneedle; the second spray component is arranged on the upper side of the carrier platform, and the second spray component is used to inject a second liquid into the molding groove to form a backing part of the microneedle; the position adjustment component is respectively driven and connected to the first spray component and the second spray component, and under the adjustment of the position adjustment component, the first nozzle of the first spray component can be aligned with the pinhole or the second nozzle of the second spray component can be aligned with the molding groove.

[0006] A microneedle production device according to the first embodiment of the present invention has at least the following technical effects:

[0007] During the operation of the microneedle production equipment of the present application, the mold is first placed on the carrier, and then the position of the first liquid spray component and the second liquid spray component is adjusted by the position adjustment component so that the first nozzle of the first liquid spray component can align with the pinholes of the molding groove, and then the first liquid spray component is used to inject the first liquid into the pinhole to form the needle body of the microneedle, and then the position of the first liquid spray component and the second liquid spray component is adjusted again by the position adjustment component so that the second nozzle of the second liquid spray component can align with the molding groove into which the first liquid has been injected, and then the second liquid spray component is used to inject the second liquid into the molding groove to form the backing part of the microneedle, thereby completing the manufacture of the microneedle substrate. It can be seen from the above working process that the present application can adjust the position of the first liquid spray component and the second liquid spray component by the position adjustment component, and inject two different liquids into the molding groove by the first liquid spray component to form the needle body part and the backing part of different materials.

[0008] According to a first embodiment of the present invention, a microneedle production device further includes a box body, a vacuum chamber is formed inside the box body, and the mold, the supporting platform, the first liquid spraying component, the second liquid spraying component and the position adjustment component are all arranged in the vacuum chamber.

[0009] According to a microneedle production device of an embodiment of the first aspect of the present invention, a humidifying component is further provided in the vacuum chamber, and the humidifying component is used to keep the humidity in the vacuum chamber within a preset range.

[0010] In a microneedle production device according to an embodiment of the first aspect of the present invention, the caliber of the first nozzle is smaller than the caliber of the second nozzle.

[0011] According to a microneedle production device of the first aspect of the embodiment of the present invention, it also includes a detection component, which is arranged on one side of the support platform and is electrically connected to the position adjustment component. The detection component is used to detect the position of the molding groove and the pinhole on the mold. The position adjustment component can adjust the position of the first nozzle and the second nozzle according to the detection result of the detection component.

[0012] According to a microneedle production device of an embodiment of the first aspect of the present invention, the support platform and the mold are both made of light-transmitting materials, and the detection component also includes a light source, which is arranged on the lower side of the support platform.

[0013] According to a microneedle production device of an embodiment of the first aspect of the present invention, a limit member is provided on the support platform, and the limit member has a first limit portion and a second limit portion, the first limit portion is used to abut against the end face of the mold in the first horizontal direction, and the second limit portion is used to abut against the end face of the mold in the second horizontal direction, and the second horizontal direction is inclined relative to the first horizontal direction.

[0014] According to a microneedle production device of an embodiment of the first aspect of the present invention, the position of the limiting member on the table surface of the supporting table can be adjusted.

[0015] According to a microneedle production device of an embodiment of the first aspect of the present invention, a plurality of elongated holes arranged along the second horizontal direction are provided on the limiting member, the elongated holes are extended along the first horizontal direction, a threaded hole is provided on the supporting platform, a threaded connector is passed through the threaded hole, and the threaded connector can be slidably passed through one of the elongated holes.

[0016] A microneedle production method according to an embodiment of the second aspect of the present invention is applied to a microneedle production device as described in the above embodiment, and the microneedle production method includes the following steps:

[0017] Place the mold on the carrier;

[0018] Evacuating the vacuum chamber;

[0019] The position adjustment component drives the first liquid spray component to move, so that the first nozzle of the first liquid spray component moves to the top of each pinhole of the forming groove in sequence, and the first nozzle completes the injection of the first material liquid in each pinhole in sequence, and when the first nozzle injects the first material liquid, there is a gap between the first nozzle and the liquid level of the first material liquid in the pinhole;

[0020] The first liquid material in the molding tank is molded to form the needle body of the microneedle;

[0021] The position adjustment component drives the second liquid spraying component to move so that the second spray head moves to the top of the forming groove;

[0022] The second liquid spraying component injects the second liquid into the forming tank so that the second liquid fills the forming tank;

[0023] The second liquid material in the molding tank is molded to form the backing part of the microneedle;

[0024] The vacuum chamber is connected to the outside to de-vacuum the vacuum chamber, so that the needle body part is closely attached to the bottom of the needle hole under the action of atmospheric pressure, and the backing part is closely attached to the bottom of the groove of the forming groove;

[0025] The needle body part and the backing part are cured to form a microneedle together.

[0026] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0028] Figure 1 It is a structural schematic diagram of a microneedle production device according to one embodiment of the present invention;

[0029] Figure 2 for Figure 1 A schematic diagram of the position structure of the box, the carrier platform, the mold, the position adjustment component and the first spray component;

[0030] Figure 3 for Figure 2 A schematic diagram of the connection structure of the mold, the carrier platform, the first liquid spraying component, the second liquid spraying component, the position adjustment component, the detection component and the humidification component;

[0031] Figure 4 for Figure 3 A schematic diagram of a part of the structure of the mold;

[0032] Figure 5 for Figure 3 A schematic diagram of the connection structure of the mounting base, the first liquid spraying assembly, the second liquid spraying assembly and the detection assembly;

[0033] Figure 6 for Figure 5 A front view of the mounting base, the first spray assembly, the second spray assembly and the detection assembly.

[0034] Reference numerals:

[0035] Mold 100, molding groove 110, pinhole 120;

[0036] The carrier 200, the threaded hole 200a, the limiting member 210, the elongated hole 210a, the first limiting portion 211, the second limiting portion 212, the waste liquid holding tank 220, and the wiping member 230;

[0037] A first liquid spraying assembly 300 and a first spray head 310;

[0038] A second liquid spraying assembly 400 and a second spray head 410;

[0039] Position adjustment assembly 500, first horizontal adjustment assembly 510, second horizontal adjustment assembly 520, horizontal driver 521, mounting seat 522, vertical adjustment assembly 530, vertical driver 531, slide seat 532;

[0040] Box body 600, vacuum chamber 610;

[0041] Detection component 700, light source 710, CCD camera 720;

[0042] Humidification component 800 , humidification structure 810 , and humidity sensor 820 . DETAILED DESCRIPTION

[0043] Embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0044] In the description of the present invention, it should be understood that descriptions involving orientation, such as up, down, left, right, front, back, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0045] In the description of the present invention, if there is a description of first and second, it is only for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0046] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0047] Reference below Figures 1 to 6 A microneedle production device according to an embodiment of the first aspect of the present invention is described in detail.

[0048] refer to Figures 2 to 4 According to an embodiment of the present invention, a microneedle production device includes a mold 100, a carrier 200, a first liquid spraying component 300, a second liquid spraying component 400 and a position adjustment component 500. The mold 100 is provided with a molding groove 110, and a plurality of pinholes 120 are opened at the bottom of the molding groove 110; the carrier 200 is used to carry the mold 100; the first liquid spraying component 300 is arranged on the upper side of the carrier 200, and the first liquid spraying component 300 is used to inject a first liquid into each pinhole 120 to form a microneedle. The needle body part; the second liquid spraying assembly 400 is arranged on the upper side of the supporting platform 200, and the second liquid spraying assembly 400 is used to inject the second material liquid into the forming groove 110 to form the backing part of the microneedle; the position adjustment assembly 500 is respectively connected to the first liquid spraying assembly 300 and the second liquid spraying assembly 400, and under the adjustment of the position adjustment assembly 500, the first nozzle 310 of the first liquid spraying assembly 300 can be aligned with the needle hole 120 or the second nozzle 410 of the second liquid spraying assembly 400 can be aligned with the forming groove 110.

[0049] During the operation of the microneedle production equipment of the present application, the mold 100 is first placed on the carrier 200, and then the positions of the first spray component 300 and the second spray component 400 are adjusted by the position adjustment component 500, so that the first nozzle 310 of the first spray component 300 can be aligned with the respective pinholes 120 of the molding groove 110, and then the first liquid is injected into each pinhole 120 through the first spray component 300 to form the needle body part of the microneedle, and then the positions of the first spray component 300 and the second spray component 400 are adjusted again by the position adjustment component 500, so that the second nozzle 410 of the second spray component 400 can be aligned with the molding groove 110 that has been injected with the first liquid, and then the second liquid is injected into the molding groove 110 through the second spray component 400 to form the backing part of the microneedle, thereby completing the manufacture of the microneedle. It can be known from the above working process that the present application can adjust the position of the first liquid spraying assembly 300 and the second liquid spraying assembly 400 through the position adjustment assembly 500, and inject two different liquids into the needle hole 120 and the forming groove 110 through the first liquid spraying assembly 300 and the second liquid spraying assembly 400, respectively, to form a needle body part and a backing part of different materials. Therefore, the first liquid can be made of a material that meets the microneedle use standard, and the second liquid can be made of other materials that can be used to produce the backing part, which can save production costs.

[0050] It can be understood that since the needle body portion of the microneedle is formed by molding the first liquid, and the backing portion of the microneedle is formed by molding the second liquid, the drug concentration in the first liquid is certain. Under the premise that the amount of the first liquid sprayed into each needle hole 120 by the first liquid spray component 300 is certain, after the first liquid in each needle hole 120 is molded to form the needle body portion, the drug content in the needle body portion is also certain. During the use of the microneedle, the drug in the microneedle mainly relies on the needle body portion to enter the human body. In the microneedle production equipment of the present invention, the staff can accurately control the drug content that a single microneedle can inject into the human body by controlling the amount of the first liquid sprayed into the needle hole 120 in the molding groove 110 by the first liquid spray component 300, so as to achieve precise quantification of the drug loading of the microneedle.

[0051] Specifically, the mold 100 is provided with a plurality of molding grooves 110 arranged in an array, and the first nozzle 310 is located at the lower side of the second nozzle 410 .

[0052] In a specific embodiment of the present invention, the position adjustment component 500 includes a first horizontal adjustment component 510, a second horizontal adjustment component 520 and a vertical adjustment component 530. The first horizontal adjustment component 510 is connected to the second horizontal adjustment component 520 and is used to drive the second horizontal adjustment component 520 to move in the first horizontal direction. The second horizontal adjustment component 520 is connected to the vertical adjustment component 530 and is used to drive the vertical adjustment component 530 to move in the second horizontal direction. The vertical adjustment component 530 includes a vertical driver 531 and a slide 532. The vertical driver 531 can drive the slide 532 to move in the vertical direction. The first spray component 300 and the second spray component 400 are both arranged on the slide 532.

[0053] It can be understood that by driving the first liquid spraying assembly 300 and the second liquid spraying assembly 400 to move synchronously through the first horizontal adjustment assembly 510, the first nozzle 310 can be aligned with the pinhole 120 in the first horizontal direction, and the second nozzle 410 can be aligned with the molding groove 110 in the first horizontal direction. By driving the first liquid spraying assembly 300 and the second liquid spraying assembly 400 to move through the second horizontal adjustment assembly 520, the first nozzle 310 can be aligned with the pinhole 120 in the second horizontal direction, and the second nozzle 410 can be aligned with the molding groove 110 in the second horizontal direction. The first and second spray heads 410 are aligned with the molding groove 110 in the horizontal direction. Therefore, by driving the first spray assembly 300 and the second spray assembly 400, the first spray assembly 300 can face the needle hole 120, or the second spray head 410 can face the molding groove 110. Then, the slide 532 is driven to move in the vertical direction by the vertical driver 531, thereby driving the first spray assembly 300 and the second spray assembly 400 to move synchronously in the vertical direction, so as to adjust the distance between the first spray head 310 and the needle hole 120 or adjust the distance between the second spray head 410 and the molding groove 110.

[0054] refer to Figure 1 and Figure 2 In some embodiments of the present invention, the microneedle production device further includes a box 600, a vacuum chamber 610 is formed inside the box 600, and the mold 100, the carrier 200, the first liquid spraying assembly 300, the second liquid spraying assembly 400 and the position adjustment assembly 500 are all arranged in the vacuum chamber 610. It can be understood that during the operation of the microneedle production device of the present application, after the first liquid spraying assembly 300 injects the first liquid into the pinhole 120, and the second liquid spraying assembly 400 injects the second liquid into the molding tank 110, the first liquid forms a needle body part in the pinhole 120, and the second liquid forms a backing part in the molding tank 110. After that, the vacuum chamber 610 can be de-vacuumed. At this time, under the action of atmospheric pressure, the first liquid can enter the bottom of the pinhole 120, and the second liquid will fill the gap of the pinhole 120 and the bottom of the molding tank 110 to improve the quality of the manufactured microneedle.

[0055] Specifically, the microneedle production equipment also includes a vacuum pump, which is connected to the box 600. The mold 100 is placed in the box 600, and then the box 600 is in a closed state. The box 600 is evacuated by the vacuum pump to form a vacuum cavity 610 in the box 600. At this time, the microneedle can be molded and manufactured.

[0056] It should be noted that the box body 600 is provided with a vacuum pump connection port and an atmospheric pressure connection port, and the vacuum pump connection port and the atmospheric pressure connection port are respectively provided with a first valve body and a second valve body, the vacuum pump connection port is connected to the vacuum pump, and the first valve body and the second valve body are both electrically connected to the controller. When the vacuum chamber 610 in the box body 600 needs to be in a vacuum state, the controller can control the first valve body to open and control the second valve body to close. At this time, the vacuum pump performs vacuuming so that the vacuum chamber 610 in the box body 600 is in a vacuum state; when the vacuum chamber 610 in the box body 600 needs to remove the vacuum state, the controller can control the first valve body to close and control the second valve body to open. At this time, the vacuum chamber 610 is connected to the external environment, and the vacuum chamber 610 is de-vacuumed.

[0057] It should be noted that since liquid is easier to evaporate in a vacuum environment and the first nozzle 310 is designed to be slender to fit the microneedle body, the first liquid is easy to dry and form during the process of being sprayed out but not completely reaching the pinhole 120. At this time, the formed first liquid cannot form a shape that fits the pinhole 120, thereby affecting the quality of the subsequently manufactured microneedles.

[0058] refer to Figure 3 In some embodiments, a humidifying component 800 is further provided in the vacuum chamber 610, and the humidifying component 800 is used to keep the humidity in the vacuum chamber 610 within a preset range. It is understandable that by providing the humidifying component 800 to keep the humidity in the vacuum chamber 610 within a preset range, the possibility of the first liquid being dried and formed before entering the pinhole 120 is reduced.

[0059] refer to Figure 3In a specific embodiment of the present invention, the humidifying assembly 800 includes two humidifying structures 810 and a humidity sensor 820. The two humidifying structures 810 are respectively arranged on two opposite cavity walls of the vacuum cavity 610. The mold 100 is arranged between the two humidifying structures 810. The humidity sensor 820 is arranged on one side of the carrier 200 and is located between the two humidifying structures 810. The humidifying structure 810 is used to increase the humidity in the vacuum cavity 610. The humidity sensor 820 is used to detect the humidity in the vacuum cavity 610. The humidity sensor 820 is electrically connected to the humidifying structure 810. It can be understood that the two humidifying structures 810 are used to humidify the positions on the opposite sides of the mold 100 respectively, so that the humidity around the mold 100 can be more uniform; the humidity in the vacuum cavity 610 is detected by the humidity sensor 820. When the humidity in the vacuum cavity 610 is lower than the preset humidity, the humidifying structure 810 operates to increase the humidity in the vacuum cavity 610 until the preset humidity is reached.

[0060] It should be noted that the volume of the microneedle body is smaller than the volume of the microneedle backing.

[0061] like Figure 5 and Figure 6 As shown, in some embodiments of the present invention, the caliber of the first nozzle 310 is smaller than the caliber of the second nozzle 410. It can be understood that by setting the caliber of the first nozzle 310 to be smaller than the caliber of the second nozzle 410, the caliber of the first nozzle 310 is adapted to the needle body volume of the microneedle, and the caliber of the second nozzle 410 is adapted to the backing volume of the microneedle, so that the first liquid spraying assembly 300 can more quickly inject the first liquid into the needle hole 120, and the second liquid spraying assembly 400 can more quickly inject the second liquid into the molding groove 110.

[0062] Specifically, the caliber of the first nozzle 310 is smaller than the diameter of the pinhole 120, so that the first nozzle 310 can spray the first liquid into the pinhole 120 and avoid spraying it outside the pinhole 120. The diameter of the molding tank 110 is relatively large, so the caliber of the second nozzle 410 can be set larger to improve the injection efficiency of the second liquid spraying assembly 400 to the molding tank 110.

[0063] refer to Figure 5 and Figure 6In some embodiments of the present invention, the microneedle production device further includes a detection component 700, which is disposed above the carrier 200 and is electrically connected to the position adjustment component 500. The detection component 700 is used to detect the positions of the molding groove 110 and the pinhole 120 on the mold 100, and the position adjustment component 500 can adjust the positions of the first nozzle 310 and the second nozzle 410 according to the detection results of the detection component 700. It can be understood that the detection component 700 detects the positions of the molding groove 110 and the pinhole 120, and the detection component 700 transmits the position information to the position adjustment component 500, and then the position adjustment component 500 adjusts the positions of the first nozzle 310 and the second nozzle 410 according to the position information, so that the first nozzle 310 or the second nozzle 410 can align with the pinhole 120 or the molding groove 110.

[0064] Specifically, the second horizontal adjustment component 520 includes a horizontal driver 521 and a mounting seat 522. The horizontal driver 521 can drive the mounting seat 522 to move along the second horizontal direction. The vertical driver 531 is set on the mounting seat 522, and the vertical driver 531 can drive the slide 532 to slide relative to the mounting seat 522. The detection component 700 includes a CCD camera 720, which is set on the mounting seat 522 and is located above the support platform 200.

[0065] like Figure 3 As shown, in some embodiments, the carrier 200 and the mold 100 are both made of light-transmitting materials, and the detection component 700 further includes a light source 710, which is disposed at the lower side of the carrier 200. It can be understood that the light source 710 is disposed under the carrier 200, and the mold 100 on the carrier 200 is illuminated by the light source 710, so that the position information of the molding groove 110 and the pinhole 120 on the mold 100 can be more clearly and accurately obtained by the detection component 700.

[0066] refer to Figure 3 In some embodiments of the present invention, a limiting member 210 is provided on the carrier 200, and the limiting member 210 has a first limiting portion 211 and a second limiting portion 212. The first limiting portion 211 is used to abut against the end face of the mold 100 in the first horizontal direction, and the second limiting portion 212 is used to abut against the end face of the mold 100 in the second horizontal direction, and the second horizontal direction is perpendicular to the first horizontal direction. It can be understood that after completing the molding of the microneedles in a mold 100, when replacing the next mold 100 for another molding, the first limiting portion 211 and the second limiting portion 212 can be used to limit the two end faces of the mold 100 in different horizontal directions, respectively, so as to realize the rapid positioning of the mold 100, which is conducive to the rapid replacement of the mold 100.

[0067] Specifically, the second horizontal direction is perpendicular to the first horizontal direction, the mold 100 is a rectangular mold, the first limiting portion 211 of the limiting member 210 is perpendicular to the second limiting portion 212, the first limiting portion 211 and the second limiting portion 212 of the limiting member 210 are respectively abutted against two surfaces perpendicular to the rectangular mold, and the first limiting portion 211 and the second limiting portion 212 are respectively fitted with the two perpendicular surfaces.

[0068] like Figure 3 As shown, in some embodiments, the position of the stopper 210 on the table surface of the carrier 200 can be adjusted. It can be understood that by adjusting the position of the stopper 210 on the carrier 200, the position of the mold 100 on the carrier 200 can be adjusted.

[0069] In some embodiments of the present invention, the stopper 210 is provided with a plurality of elongated holes 210a arranged along the second horizontal direction, the elongated holes 210a are extended along the first horizontal direction, the carrier 200 is provided with a threaded hole 200a, a threaded connector is inserted into the threaded hole 200a, and the threaded connector can be slidably inserted into one of the elongated holes 210a. It can be understood that since the plurality of elongated holes 210a are arranged along the second horizontal direction, the position adjustment of the stopper 210 in the second horizontal direction can be achieved by selectively inserting the threaded connector into one of the elongated holes 210a and threading it with the carrier 200, thereby achieving the adjustment of the position of the mold 100 in the second horizontal direction, and then by sliding the threaded connector in the elongated hole 210a extending along the first horizontal direction, and then screwing the threaded connector until the threaded connector locks the stopper 210 on the carrier 200, the position adjustment of the stopper 210 in the first horizontal direction is achieved, thereby achieving the adjustment of the position of the mold 100 on the carrier 200.

[0070] In a further embodiment of the present invention, a plurality of threaded holes 200 a distributed at intervals are arranged on the support platform 200 along the first horizontal direction.

[0071] It should be noted that when the microneedle production device of the present invention is working, during the process of vacuuming in the vacuum chamber 610, the viscosity and content of the first liquid in the first nozzle 310 will change, and the viscosity and content of the second liquid in the second nozzle 410 will change; after the first liquid spraying assembly 300 and the second liquid spraying assembly 400 have been operating for a period of time, the viscosity and content of the first liquid in the first nozzle 310 will also change, and the viscosity and content of the second liquid in the second nozzle 410 will change. In the above two cases, if the first liquid spraying assembly 300 and the second liquid spraying assembly 400 directly inject the first liquid and the second liquid into the mold 100, the quality of the microneedles formed in the mold 100 is poor and it is difficult to meet the use requirements.

[0072] Based on the above problems, refer to Figure 3 In some embodiments of the present invention, a waste liquid holding tank 220 is also provided on the carrier platform 200 . It can be understood that before the first spray component 300 and the second spray component 400 are injected, they are first moved to the waste liquid holding tank 220 through the position adjustment component 500, and a section of liquid is discharged into the waste liquid holding tank 220, which is beneficial to discharge the gas in the pipelines of the first spray component 300 and the second spray component 400, and reduce the possibility of unstable discharge of subsequent liquid; a section of liquid is discharged into the waste liquid holding tank 220 by the first spray component 300 and the second spray component 400, so as to discharge the first liquid with changed viscosity and content in the first nozzle 310, and to discharge the second liquid with changed viscosity and content in the second nozzle 410, so that when the first spray component 300 sprays liquid into the mold 100, the first liquid with viscosity and content that meet the standards can be sprayed, and when the second spray component 400 sprays liquid into the mold 100, the second liquid with viscosity and content that meet the standards can be sprayed, thereby improving the quality of the microneedles manufactured by the microneedle production equipment of the present invention.

[0073] refer to Figure 3 In some embodiments of the present invention, a wiper 230 is further provided on the carrier 200, and the wiper 230 is used to wipe the first nozzle 310 or the second nozzle 410. It is understandable that after the first liquid spraying assembly 300 and the second liquid spraying assembly 400 have been running for a period of time, the first liquid spraying assembly 300 or the second liquid spraying assembly 400 is driven by the position adjustment assembly 500 to move to the wiper 230, and the first nozzle 310 or the second nozzle 410 is wiped by the wiper 230, so as to reduce the possibility of the first liquid or the second liquid blocking the first nozzle 310 or the second nozzle 410.

[0074] Specifically, the horizontal height of the first nozzle 310 is lower than the horizontal height of the second nozzle 410. It should be understood that the first nozzle 310 and the second nozzle 410 can be synchronously translated and lifted under the drive of the position adjustment component 500, and in order to facilitate the first nozzle 310 to align with the pinhole 120, the first nozzle 310 is closer to the pinhole 120 when spraying liquid to the pinhole 120, and the horizontal height of the second nozzle 410 is set higher, which can reduce the risk of the second nozzle 410 hitting the mold 100.

[0075] In some other embodiments of the present invention, the first nozzle 310 or the second nozzle 410 is distributed along the second horizontal direction, and the distance between two adjacent molding grooves 110 in the second horizontal direction is set to be consistent with the distance between the first nozzle 310 or the second nozzle 410. When the first nozzle 310 sprays liquid on the pinhole 120 corresponding to one of the molding grooves 110, the second nozzle 410 sprays liquid on the other molding groove 110 that has completed the spraying of the pinhole 120, thereby improving production efficiency. In addition, driven by the first horizontal adjustment component 510 and the second horizontal adjustment component 520, the first nozzle 310 can spray liquid on multiple pinholes 120. At the same time, the second nozzle 410 will also move in the horizontal direction above the other molding groove 110, so that the second nozzle 410 can spray liquid on each position of the molding groove 110, so that the second liquid in the molding groove 110 is evenly distributed. In some other embodiments of the present invention, the first nozzle 310 can enter the molding groove 110 and be located above the pinhole 120. Since the horizontal height of the second nozzle 410 is higher than the horizontal height of the first nozzle 310, when the first nozzle 310 or the second nozzle 410 performs synchronous spraying, it can be ensured that the second nozzle 410 can be located above the other molding groove 110 without entering the molding groove 110, thereby ensuring that the second nozzle 410 can spray liquid to the molding groove 110 normally.

[0076] A microneedle production method according to an embodiment of the second aspect of the present invention is described in detail below.

[0077] A microneedle production method according to an embodiment of the second aspect of the present invention is applied to a microneedle production device as described in the above embodiment, and the microneedle production method includes but is not limited to the following steps:

[0078] Place the mold 100 on the carrier 200;

[0079] Evacuate the vacuum chamber 610;

[0080] The position adjustment component 500 drives the first liquid spraying component 300 to move, so that the first spray head 310 of the first liquid spraying component 300 moves sequentially to the top of each pinhole 120 of the forming groove 110, and the first spray head 310 sequentially completes the injection of the first material liquid in each pinhole 120, and when the first spray head 310 injects the first material liquid, there is a gap between the first spray head 310 and the liquid surface of the first material liquid in the pinhole 120;

[0081] The first liquid material in the molding tank 110 is molded to form the needle body of the microneedle;

[0082] The position adjustment component 500 drives the second liquid spraying component 400 to move so that the second spray head 410 moves to the top of the molding groove 110;

[0083] The second liquid spraying assembly 400 injects the second liquid into the molding tank 110 so that the second liquid fills the molding tank 110;

[0084] The second liquid material in the molding tank 110 is molded to form the backing part of the microneedle;

[0085] The vacuum chamber 610 is connected to the outside to de-vacuum the vacuum chamber 610, so that the needle body part is closely attached to the bottom of the needle hole 120 under the action of atmospheric pressure, and the backing part is closely attached to the bottom of the groove 110;

[0086] The needle body part and the backing part are cured to form a microneedle together.

[0087] It can be understood that the mold 100 is first placed on the carrier 200, and the vacuum chamber 610 of the box 600 is evacuated, and then the first liquid spraying assembly 300 is driven to move by the position adjustment assembly 500, so that the first nozzle 310 on the first liquid spraying assembly 300 can be moved to the top of each pinhole 120 of the molding groove 110 in sequence, and the first liquid is injected into each pinhole 120. After the first liquid in the molding groove 110 is formed into the needle body part of the microneedle, the position adjustment assembly 500 is used to drive the first liquid spraying assembly 300 to move. Component 500 drives the second liquid spray component 400 to move so that the second nozzle 410 on the second liquid spray component 400 moves to the top of the molding tank 110, and then injects the second liquid into the molding tank 110 through the second liquid spray component 400, so that the second liquid fills the molding tank 110, and the second liquid in the molding tank 110 is molded to form the backing part of the microneedle, and then the vacuum chamber 610 is connected to the outside to de-vacuum the vacuum chamber 610, and the needle body part and the backing part are solidified to form a microneedle together.

[0088] It can be understood that due to the gap between the first nozzle 310 and the liquid surface of the first liquid in the needle hole 120, non-contact liquid injection is achieved, which reduces the influence of the first liquid surface tension, capillary action, electrostatic action, adhesion and contact angle on the injection of the first liquid, thereby reducing the possibility of inaccurate injection amount due to adhesion to the first nozzle 310.

[0089] It can be understood that in the microneedle production method of the present invention, after the first liquid spray component 300 injects the first liquid into the needle hole 120, and the second liquid spray component 400 injects the second liquid into the molding groove 110, the first liquid forms a needle body portion in the needle hole 120, and the second liquid forms a backing portion in the molding groove 110. After that, the vacuum chamber 610 can be devacuated. At this time, under the action of atmospheric pressure, the first liquid can be tightly pressed into the bottom of the needle hole 120, and the second liquid will fill the gap of the needle hole 120 and be tightly pressed into the bottom of the molding groove 110, so as to improve the quality of the manufactured microneedles.

[0090] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A microneedle production device, characterized in that: include: A mold, wherein the mold is provided with a molding groove, and a plurality of pinholes are opened at the bottom of the molding groove; A carrying platform, used for carrying the mold; A first liquid spraying assembly is disposed on the upper side of the carrier platform, and is used to inject a first liquid into each of the needle holes to form a needle body portion of the microneedle; A second liquid spraying assembly is disposed on the upper side of the carrier platform, and is used to inject a second liquid into the forming groove to form a backing portion of the microneedle; A position adjustment component is respectively connected to the first liquid spray component and the second liquid spray component in driving relation. Under the adjustment of the position adjustment component, the first nozzle of the first liquid spray component can be aligned with the pinhole or the second nozzle of the second liquid spray component can be aligned with the forming groove.

2. A microneedle production device according to claim 1, characterized in that: It also includes a box body, a vacuum chamber is formed inside the box body, and the mold, the supporting platform, the first liquid spraying component, the second liquid spraying component and the position adjustment component are all arranged in the vacuum chamber.

3. A microneedle production device according to claim 2, characterized in that: A humidifying component is also provided in the vacuum chamber, and the humidifying component is used to keep the humidity in the vacuum chamber within a preset range.

4. A microneedle production device according to claim 1 or 2, characterized in that: The caliber of the first nozzle is smaller than the caliber of the second nozzle.

5. A microneedle production device according to claim 1 or 2, characterized in that: It also includes a detection component, which is arranged on one side of the support platform and is electrically connected to the position adjustment component. The detection component is used to detect the positions of the molding groove and the pinhole on the mold. The position adjustment component can adjust the positions of the first nozzle and the second nozzle according to the detection results of the detection component.

6. A microneedle production device according to claim 5, characterized in that: The supporting platform and the mold are both made of light-transmitting materials. The detection component also includes a light source, and the light source is arranged at the lower side of the supporting platform.

7. A microneedle production device according to claim 1 or 2, characterized in that: A limiting member is provided on the supporting platform, and the limiting member has a first limiting portion and a second limiting portion, the first limiting portion is used to abut against the end surface of the mold in a first horizontal direction, and the second limiting portion is used to abut against the end surface of the mold in a second horizontal direction, and the second horizontal direction is inclined relative to the first horizontal direction.

8. A microneedle production device according to claim 7, characterized in that: The position of the limiting member on the surface of the supporting platform can be adjusted.

9. A microneedle production device according to claim 8, characterized in that: The limiting member is provided with a plurality of elongated holes arranged along the second horizontal direction, the elongated holes are extended along the first horizontal direction, the supporting platform is provided with threaded holes, a threaded connector is passed through the threaded holes, and the threaded connector can be slidably passed through one of the elongated holes.

10. A method for producing a microneedle, characterized in that: Applied to a microneedle production device as claimed in any one of claims 2 to 9, the microneedle production method comprises the following steps: placing the mold on the carrying platform; evacuating the vacuum chamber; The position adjustment component drives the first liquid spray component to move, so that the first nozzle of the first liquid spray component moves to the top of each of the pinholes of the forming groove in sequence, and the first nozzle completes the injection of the first material liquid in each of the pinholes in sequence, and when the first nozzle is injecting liquid, there is a gap between the first nozzle and the liquid surface of the first material liquid in the pinhole; The first liquid material in the molding tank is molded to form a needle body portion of the microneedle; The position adjustment component drives the second liquid spraying component to move so that the second spray head moves to above the forming groove; The second liquid spraying component injects the second liquid into the molding tank, so that the second liquid fills the molding tank; The second liquid in the molding tank is molded to form a backing portion of the microneedle; The vacuum chamber is connected to the outside to de-vacuum the vacuum chamber, so that the needle body part is closely attached to the bottom of the needle hole under the action of atmospheric pressure, and the backing part is closely attached to the bottom of the forming groove; The needle body part and the backing part form a microneedle together after being cured.

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