Synthesis process of creatinine
By using creatine monohydrate and low-saturated fatty acids in the creatinine synthesis process and controlling the reaction conditions, the problems of low solubility and by-products in the traditional process are solved, and the efficient synthesis of creatinine and high-quality precipitation of products are achieved.
Patent Information
- Application Number
- CN202510101761.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-22
- Publication Date
- 2025-04-15
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Traditional creatinine synthesis processes have low solubility, long reaction time and by-products, resulting in poor product quality.
Creatine monohydrate and low-saturated fatty acids are used as the reaction base solution. By adding hydrochloric acid and ammonia aqueous solution, the reaction temperature and pH value are controlled to achieve efficient reaction and precipitation of creatinine.
The dispersion and dissolution effect of the reaction solvent is improved, the reaction is carried out fully, the side reaction effect is reduced, and the product is efficiently precipitated in a weakly alkaline low temperature environment.
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Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of wastewater treatment, in particular to a synthesis process of creatinine. Background Art
[0002] Creatinine, also known as creatinine, is a product of muscle metabolism in the human body. Every 20g of muscle metabolism can produce 1mg of creatinine. It is mainly composed of two parts: one is exogenous creatinine, which is the creatinine produced by the decomposition of meat eaten every day in the body; the other is endogenous creatinine, which is the creatinine generated by the metabolism of one's own muscle tissue.
[0003] The products of the traditional creatinine synthesis process have low dissolution rate, long reaction time and the appearance of by-products. Therefore, a synthesis process is needed to solve the above problems. Summary of the invention
[0004] The purpose of the invention is to provide a synthesis process of creatinine to solve the deficiencies in the prior art.
[0005] The technical solution adopted by the present invention is as follows: The synthesis process of creatinine comprises the following steps: (1) Preparation of raw materials: Place creatine monohydrate and low-order saturated fatty acids in a reaction vessel as a reaction base liquid; (2) Mixing the reaction solution: adding hydrochloric acid and an aqueous ammonia solution to the reaction base solution prepared in step 1 to obtain a reaction solution; (3) Reaction and precipitation of creatinine: The reaction solution obtained in step (2) is heated to 400 °C and then kept warm for a period of time before being cooled for the first time. Ammonia water is added dropwise to adjust the pH value while maintaining the temperature of the first cooling, and then the reaction solution is cooled for the second time to precipitate creatinine.
[0006] Preferably, the low saturated fatty acid in step (1) is a mixture of one or more of butyric acid, valeric acid and caproic acid.
[0007] Preferably, the concentration of the hydrochloric acid solution in step (2) is an aqueous solution with a mass fraction of 28-32%, and the concentration of the ammonia water is an aqueous solution with a mass fraction of 18-22%.
[0008] Preferably, the molar ratio of the reaction base liquid to the total amount of hydrochloric acid and ammonia solution in step (2) is 1:1-1.2.
[0009] Preferably, the temperature of the first heating in step (3) is 80-90°C, the insulation time is 7.5-8h, the temperature of the first cooling is 38-42°C, the pH value adjusted by adding ammonia water is in the range of 7.5-8.5, and the temperature of the second cooling is -2-2°C.
[0010] Beneficial effects of the present invention: During the treatment process of the crystallization process of the present invention, by using a mixture of multiple low-level saturated fatty acids, the dispersion and dissolution effects of the reaction solvent can be improved, ensuring that the subsequent reaction is fully carried out. The first heating and insulation for a period of time has an energy supply catalytic effect on the reaction, ensuring the smooth progress of the reaction process, and can greatly reduce the effects of side reactions. Finally, maintaining the pH value at a weak alkaline and a low temperature environment is conducive to the precipitation of the product. DETAILED DESCRIPTION Example 1
[0011] The synthesis process of creatinine comprises the following steps: Preparation of raw materials: Place creatine monohydrate and low-grade saturated fatty acids in a reaction vessel as reaction base liquid; (2) Mixing the reaction solution: adding hydrochloric acid and an aqueous ammonia solution to the reaction base solution prepared in step 1 to obtain a reaction solution; (3) Reaction and precipitation of creatinine: The reaction solution obtained in step (2) is heated to 400 °C and then kept warm for a period of time before being cooled for the first time. Ammonia water is added dropwise to adjust the pH value while maintaining the temperature of the first cooling, and then the reaction solution is cooled for the second time to precipitate creatinine.
[0012] In step (1), the low saturated fatty acid is one of butyric acid, valeric acid and caproic acid.
[0013] The concentration of the hydrochloric acid solution in step (2) is an aqueous solution with a mass fraction of 28%, and the concentration of the ammonia water is an aqueous solution with a mass fraction of 18%.
[0014] The molar ratio of the reaction base liquid to the total amount of hydrochloric acid and ammonia solution in step (2) is 1:1.
[0015] In step (3), the first heating temperature is 80°C, the insulation time is 7.5h, the first cooling temperature is 38°C, the pH value adjusted by adding ammonia water is 7.5, and the second cooling temperature is -2°C. Example 2
[0016] The synthesis process of creatinine is characterized by comprising the following steps: Preparation of raw materials: Place creatine monohydrate and low-grade saturated fatty acids in a reaction vessel as reaction base liquid; (2) Mixing the reaction solution: adding hydrochloric acid and an aqueous ammonia solution to the reaction base solution prepared in step 1 to obtain a reaction solution; (3) Reaction and precipitation of creatinine: The reaction solution obtained in step (2) is heated to 400 °C and then kept warm for a period of time before being cooled for the first time. Ammonia water is added dropwise to adjust the pH value while maintaining the temperature of the first cooling, and then the reaction solution is cooled for the second time to precipitate creatinine.
[0017] In step (1), the low saturated fatty acid is a mixture of two of butyric acid, valeric acid and caproic acid.
[0018] The concentration of the hydrochloric acid solution in step (2) is an aqueous solution with a mass fraction of 30%, and the concentration of the ammonia water is an aqueous solution with a mass fraction of 22%.
[0019] The molar ratio of the reaction base liquid to the total amount of hydrochloric acid and ammonia solution in step (2) is 1:1.1.
[0020] In step (3), the first heating temperature is 85°C, the insulation time is 7.8h, the first cooling temperature is 40°C, the pH value adjusted by adding ammonia water is in the range of 8, and the second cooling temperature is 0°C. Example 3
[0021] The synthesis process of creatinine is characterized by comprising the following steps: Preparation of raw materials: Place creatine monohydrate and low-grade saturated fatty acids in a reaction vessel as reaction base liquid; (2) Mixing the reaction solution: adding hydrochloric acid and an aqueous ammonia solution to the reaction base solution prepared in step 1 to obtain a reaction solution; (3) Reaction and precipitation of creatinine: The reaction solution obtained in step (2) is heated to 400 °C and then kept warm for a period of time before being cooled for the first time. Ammonia water is added dropwise to adjust the pH value while maintaining the temperature of the first cooling, and then the reaction solution is cooled for the second time to precipitate creatinine.
[0022] In step (1), the low saturated fatty acid is a mixture of butyric acid, valeric acid and caproic acid.
[0023] The concentration of the hydrochloric acid solution in step (2) is an aqueous solution with a mass fraction of 32%, and the concentration of the ammonia water is an aqueous solution with a mass fraction of 22%.
[0024] The molar ratio of the reaction base liquid to the total amount of hydrochloric acid and ammonia solution in step (2) is 1:1.2.
[0025] In step (3), the first heating temperature is 90°C, the heat preservation time is 8h, the first cooling temperature is 42°C, the pH value adjusted by adding ammonia water is 8.5, and the second cooling temperature is 2°C.
[0026] Comparative Example 1 Creatinine synthesized using traditional technology.
[0027] The specific indicators for comparison are:
[0028] It can be seen from the above table that the process provided by the present invention can ensure that the reaction is fully carried out, can increase the product yield, and reduce side reactions.
[0029] The above description is only a preferred embodiment of the present invention, but the present invention does not limit the scope of implementation. Any changes made in accordance with the concept of the present invention, or modifications to equivalent embodiments with equivalent changes, which still do not exceed the spirit covered by the description and embodiments, should be within the protection scope of the present invention.
Claims
1. A process for synthesizing creatinine, characterized in that: The following steps are involved: (1) Preparation of raw materials: Place creatine monohydrate and low-order saturated fatty acids in a reaction vessel as a reaction base liquid; (2) Mixing the reaction solution: adding hydrochloric acid and an aqueous ammonia solution to the reaction base solution prepared in step 1 to obtain a reaction solution; (3) Reaction and precipitation of creatinine: The reaction solution obtained in step (2) is heated to 400 °C and then kept warm for a period of time before being cooled for the first time. Ammonia water is added dropwise to adjust the pH value while maintaining the temperature of the first cooling, and then the reaction solution is cooled for the second time to precipitate creatinine.
2. The synthesis process of creatinine according to claim 1, characterized in that: The low saturated fatty acid in step (1) is a mixture of one or more of butyric acid, valeric acid and caproic acid.
3. The synthesis process of creatinine according to claim 1, characterized in that: The concentration of the hydrochloric acid solution in step (2) is an aqueous solution with a mass fraction of 28-32%, and the concentration of the ammonia water is an aqueous solution with a mass fraction of 18-22%.
4. The synthesis process of creatinine according to claim 1, characterized in that: The molar ratio of the reaction base liquid to the total amount of hydrochloric acid and ammonia solution in step (2) is 1:1-1.
2.
5. The synthesis process of creatinine according to claim 1, characterized in that: In step (3), the first heating temperature is 80-90°C, the insulation time is 7.5-8h, the first cooling temperature is 38-42°C, the pH value adjusted by adding ammonia water is in the range of 7.5-8.5, and the second cooling temperature is -2-2°C.