Multilayer filtration blood purification dialysis equipment

Abstract

The invention discloses multi-layer filtration blood purification dialysis equipment, and relates to the technical field related to hemodialysis, through a hollow fiber membrane, multi-layer filtration and pressure regulation collaboration are integrated, and a nanofiber membrane, anion resin, activated carbon and a molecular sieve adsorption layer of which the pore diameters are gradually decreased are integrated in each filter tube; the removal rates of urea, creatinine and phosphorus respectively reach 92%, 88% and 78% and are improved by 25%-40% compared with single-stage filtration, the repeated utilization rate of dialysate is improved to 75% or above, the consumption of single treatment is reduced to 25% of that of conventional equipment, meanwhile, through arrangement of a pressure valve, the waste liquid discharge amount is accurately matched with the toxin accumulation rate, and the treatment effect is improved. The concentration fluctuation of dialysate metabolites is controlled within + / -10%, and the KT / V value is stabilized to be 1.3 or above.

Description

Technical Field

[0001] The present invention relates to the technical field related to hemodialysis, and in particular to a multi-layer filtering blood purification dialysis device. Background Art

[0002] Hemodialysis technology is the core treatment method for replacing kidney function. It removes metabolic waste, electrolytes and excess water from the patient's blood through the extracorporeal circulation system. Its basic principle is based on the solute concentration gradient difference between the solutions on both sides of the semipermeable membrane. Toxin removal is achieved through diffusion and convection, and ultrafiltration is relied on to regulate fluid balance. Since the invention of the rotary drum artificial kidney in the 1940s, hemodialysis technology has undergone three major innovations: hollow fiber membranes, high-flux dialyzers and online blood filtration, but the core principle still relies on the material exchange of disposable dialysate.

[0003] Currently, about 3.5 million patients with end-stage renal disease worldwide rely on hemodialysis to maintain their lives. However, existing technologies still face significant bottlenecks: traditional equipment uses an open dialysate system, and a single treatment consumes 120-150L of dialysate, resulting in a waste of resources; the semi-permeable membrane pores are easily blocked by plasma proteins; the removal efficiency of medium-molecular toxins with a molecular weight between 500-15,000Da is insufficient, and the β2-microglobulin clearance rate is <50%; and due to the unidirectional flow characteristics of the dialysate, the solute clearance rate decreases in the later stages of treatment. Although adsorption dialyzers and reverse osmosis technology have been tried for dialysate regeneration, there are still technical defects such as electrolyte imbalance and short filter layer life. Summary of the invention

[0004] The purpose of the present invention is to provide a multi-layer filtration blood purification dialysis device to solve the problem that the traditional hemodialysis device mentioned in the above background cannot recycle the dialysate, resulting in a large amount of dialysate usage.

[0005] To achieve the above-mentioned object, the present invention provides the following technical solutions: a multi-layer filtration blood purification dialysis device, comprising a hemodialysis machine, a dialyzer slot is arranged on the hemodialysis machine, a circulation driver is arranged at the bottom of the dialyzer slot, a driving motor is arranged in the circulation driver, an output shaft of the driving motor is fixedly connected to an inclined driving disk through a key slot, a lifting rod is slidably connected to the upper part of the circulation driver through a first sliding sleeve, the lifting rod penetrates the circulation driver, and a first magnet sheet is fixedly connected to the upper end of the lifting rod;

[0006] A hemodialyzer is inserted into the dialyzer slot, a dialysis cartridge is arranged in the center of the hemodialyzer, four filter cartridges are arranged around the dialysis cartridge, a filter column is arranged in the filter cartridge, the bottom of the filter cartridge is connected with the dialysis cartridge through a first connecting tube, a one-way valve is arranged in the first connecting tube, the upper part of the filter cartridge is connected with the dialysis cartridge through a second connecting tube, a one-way valve is arranged in the second connecting tube, a waste liquid discharge port is provided in the filter cartridge, a dialysate replenishing port is provided at the upper end of the filter cartridge, and a diaphragm pump is arranged at the lower end of the filter column.

[0007] In one example, the plane where the tilted driving plate is located is at an angle of 85°-95° ​​with the output shaft of the driving motor, so that the tilted driving plate can periodically drive the diaphragm pump when it rotates.

[0008] In one example, an annular contact groove is provided on the tilt drive disk, and a ball is provided at the bottom end of the lifting rod. The ball rolls in the contact groove, so that the tilt drive disk drives the lifting rod more stably and prevents the lifting rod from shaking.

[0009] In one example, a shunt chamber is provided at the upper end of a dialysis cylinder, a dialysis chamber is provided below the shunt chamber, the shunt chamber and the dialysis chamber are separated by a first partition, a confluence chamber is provided below the dialysis chamber, the confluence chamber and the dialysis chamber are separated by a second partition, dense hollow fibers are provided between the first partition and the second partition, blood is diverted from the shunt chamber into thousands of hollow fibers, then exchanges substances with the dialysate in the dialysis chamber, and finally merges into the confluence chamber.

[0010] In one example, a blood injection tube and a blood discharge tube are provided at the upper end of the dialysis cylinder. The blood injection tube is connected to the shunt chamber, and the blood discharge tube runs through the dialysis chamber and is connected to the confluence chamber, so that blood can enter the dialysis cylinder from the blood injection tube and then flow out from the confluence chamber through the blood discharge tube.

[0011] In one example, the hollow fiber is made of polysulfone, which has good hydrophilicity, a glass transition temperature of 190°C, is resistant to high-temperature disinfection, can be steam sterilized at 121°C, has a porosity of 60% to 70%, and has both high mechanical strength and biocompatibility. Its tensile strength can reach 5MPa. Amino groups are introduced on the surface of the hollow fiber membrane through plasma activation. The amino groups are covalently bonded to the heparin carboxyl groups, extending the clotting time to 300-400s.

[0012] In one example, one end of the first connecting tube is connected to the bottom of the dialysis chamber, and the other end is connected to the bottom of the filter column. The waste liquid outlet is also arranged below the filter column. One end of the second connecting tube is connected to the top of the dialysis chamber, and the other end is connected to the top of the filter column. The dialysate replenishment port is opened above the filter column.

[0013] In one example, the filter column is divided into four layers from bottom to top, namely, nanofiber membrane layer, anion resin layer, activated carbon layer and molecular sieve adsorption layer. The combination of the four filter layers can achieve clearance rates of 92%, 88% and 78% for urea, creatinine and phosphorus respectively, and can effectively recover the dialysate.

[0014] In one example, the diaphragm pump includes a second sliding sleeve, and the bottom of the filter cartridge is slidably connected to a lifting piston column through the second sliding sleeve. The upper end of the lifting piston column is fixedly connected to a rubber bowl, and the edge of the rubber bowl is fixedly connected to the inner wall of the filter cartridge. The lower end of the lifting piston column is fixedly connected to a second magnet sheet, and a return spring is arranged between the second magnet sheet and the bottom of the filter cartridge, and the return spring sleeve is arranged on the outside of the lifting piston column.

[0015] In one example, four groups of lifting rods, first magnet sheets and diaphragm pumps are provided, and the four groups of diaphragm pumps are respectively located at the bottom of four filter cartridges, the second magnet sheets in each group of diaphragm pumps respectively correspond to a first magnet sheet, and the first magnet sheets and the second magnet sheets attract each other.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] 1. The present invention proposes a multi-layer filtration blood purification dialysis device, which cooperates with hollow fiber membrane, integrated multi-layer filtration and pressure regulation. Each filter tube integrates nanofiber membrane with decreasing pore size, anion resin, activated carbon and molecular sieve adsorption layer. The clearance rates of urea, creatinine and phosphorus reach 92%, 88% and 78% respectively, which are 25% to 40% higher than single-stage filtration. At the same time, the dialysate reuse rate is increased to more than 75%, and the consumption of a single treatment is reduced to 25% of conventional equipment.

[0018] 2. The multi-layer filtration blood purification dialysis equipment proposed in the present invention adopts a mechanical design of four diaphragm pumps linked by an inclined turntable. The phase difference of each diaphragm pump is 90°, which realizes the continuous alternation of compression and expansion states, reduces the fluctuation amplitude of dialysate flow to ±5%, improves the transmembrane pressure stability by 40%, and extends the service life by more than 30% by the motor load balancing design.

[0019] 3. The multi-layer filtration blood purification dialysis equipment proposed by the present invention utilizes the siphon effect generated by the negative pressure phase of the diaphragm pump to achieve periodic reverse flushing, and the pressure valve will also give priority to discharging the flushing waste liquid in the next cycle, thereby extending the effective working time of the filtration layer to 12-15 hours, reducing the transmembrane pressure growth rate by 40%, and reducing protein deposition by 60%.

[0020] 4. The present invention proposes a multi-layer filtration blood purification dialysis equipment. Through the setting of the pressure valve, the amount of waste liquid discharged by the pressure valve depends on the pressure below the filter column. The pressure below the filter column depends on the resistance of the dialysate through the filter column when the diaphragm pump is compressed. When the blockage degree of the filter column increases, the filtration effect on the dialysate decreases, and the concentration of metabolites in the dialysate increases. At the same time, when the diaphragm pump is compressed, the amount of waste liquid discharged by the pressure valve will also increase, so that the waste liquid discharge volume accurately matches the toxin accumulation rate, and the fluctuation of the concentration of dialysate metabolites is controlled within ±10%, and the KT / V value is stabilized at above 1.3. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The disclosure of the present invention is described with reference to the accompanying drawings. It should be understood that the drawings are for illustrative purposes only and are not intended to limit the scope of protection of the present invention. In the accompanying drawings, the same reference numerals are used to refer to the same components. Among them:

[0022] Figure 1 A schematic diagram of the structure of a multi-layer filtration blood purification dialysis device proposed according to one embodiment of the present invention is shown;

[0023] Figure 2 A schematic diagram of a cross-sectional structure of a circulation driver of a multi-layer filtration blood purification dialysis device proposed according to an embodiment of the present invention is shown;

[0024] Figure 3 A schematic diagram of the structure of a hemodialyzer of a multi-layer filtration blood purification dialysis device proposed according to one embodiment of the present invention is shown;

[0025] Figure 4 A schematic diagram of a cross-sectional structure of a hemodialyzer of a multi-layer filtration blood purification dialysis device proposed in accordance with an embodiment of the present invention is shown;

[0026] Figure 5 A schematic diagram of a multi-layer filtration blood purification dialysis device according to an embodiment of the present invention is shown. Figure 4 The enlarged structural diagram at A in the middle;

[0027] Figure 6 The schematic diagram of the cross-sectional structure of a dialysis cartridge of a multi-layer filtration blood purification dialysis device proposed in accordance with one embodiment of the present invention is shown;

[0028] Figure 7 The schematic diagram of the structure of a diaphragm pump of a multi-layer filtration blood purification dialysis device proposed according to one embodiment of the present invention is shown schematically.

[0029] In the figure: 1, hemodialysis machine; 2, dialyzer slot; 3, circulation drive; 4, drive motor; 5, tilting drive plate; 501, contact slot; 6, first sliding sleeve; 7, lifting rod; 701, ball bearing; 8, first magnet sheet; 9, hemodialysis machine; 10, dialysis cartridge; 1001, diversion chamber; 1002, dialysis chamber; 1003, first partition; 1004, confluence chamber; 1005, second partition; 1006, hollow fiber; 1007, blood injection tube; 1008, blood injection tube; 1009, blood injection tube; 1010, blood injection tube; 1011, blood injection tube; 1012, blood injection tube; 1013, blood injection tube; 1014, blood injection tube; 1015, blood injection tube; 1016, blood injection tube; 1017, blood injection tube; 1018, blood injection tube; 1019, blood injection tube; 1020, blood injection tube; 1021, blood injection tube; 1022, blood injection tube; 1023, blood injection tube; 1024, blood injection tube; 1025, blood injection tube; 1026, blood injection tube; 1027, blood injection tube; 1028, blood injection tube; 1029, blood injection tube; 1030, blood injection tube; 1031, blood injection tube; 1032, blood injection tube; 1033, blood injection tube; 1034, blood injection tube; 1035, blood injection tube; 1036, blood injection tube; 1037, blood injection tube; 1038, blood injection tube; 1039, blood injection tube; 1040, blood injection tube; 1041, blood injection tube; 1042, blood 08. Blood discharge tube; 11. Filter cartridge; 12. Filter column; 1201. Nanofiber membrane layer; 1202. Anion resin layer; 1203. Activated carbon layer; 1204. Molecular sieve adsorption layer; 13. First connecting tube; 14. Second connecting tube; 15. Waste liquid outlet; 16. Dialysis fluid replenishment port; 17. Diaphragm pump; 1701. Second sliding sleeve; 1702. Lifting piston column; 1703. Rubber bowl; 1704. Second magnet sheet; 1705. Return spring. DETAILED DESCRIPTION

[0030] It is easy to understand that according to the technical solution of the present invention, without changing the essential spirit of the present invention, a person skilled in the art can propose a variety of interchangeable structural modes and implementation modes. Therefore, the following specific implementation modes and drawings are only exemplary descriptions of the technical solution of the present invention, and should not be regarded as the whole of the present invention or as a limitation or restriction to the technical solution of the present invention.

[0031] Example 1: Figure 1-7 As shown, a multi-layer filtration blood purification dialysis equipment includes a hemodialysis machine 1, a dialyzer slot 2 is provided on the hemodialysis machine 1, a circulation drive 3 is provided at the bottom of the dialyzer slot 2, a drive motor 4 is provided in the circulation drive 3, and the output shaft of the drive motor 4 is fixedly connected to an inclined drive disk 5 through a key slot, and the plane where the inclined drive disk 5 is located is at an angle of 85°-95° ​​with the output shaft of the drive motor 4, so that the diaphragm pump 17 can be periodically driven when the inclined drive disk 5 rotates.

[0032] The upper part of the circulating driver 3 is slidably connected to a lifting rod 7 via a first sliding sleeve 6. An annular contact groove 501 is provided on the tilting driving disk 5. A ball 701 is provided at the bottom end of the lifting rod 7. The ball 701 rolls in the contact groove 501, so that the tilting driving disk 5 drives the lifting rod 7 more stably and prevents the lifting rod 7 from shaking. The lifting rod 7 passes through the circulating driver 3, and a first magnet sheet 8 is fixedly connected to the upper end of the lifting rod 7.

[0033] A hemodialyzer 9 is inserted into the dialyzer slot 2, a dialyzer cartridge 10 is arranged at the center of the hemodialyzer 9, a shunt chamber 1001 is arranged at the upper end of the dialysis cartridge 10, a dialysis chamber 1002 is arranged below the shunt chamber 1001, the shunt chamber 1001 and the dialysis chamber 1002 are separated by a first partition 1003, a confluence chamber 1004 is arranged below the dialysis chamber 1002, the confluence chamber 1004 and the dialysis chamber 1002 are separated by a second partition 1005, and a dense The hollow fiber 1006 of the dialysis cartridge 10 is provided with a blood injection tube 1007 and a blood discharge tube 1008 at the upper end thereof. The blood injection tube 1007 is connected with the shunt chamber 1001, and the blood discharge tube 1008 runs through the dialysis chamber 1002 and is connected with the confluence chamber 1004, so that the blood is pumped into the shunt chamber 1001 through the blood injection tube 1007, and then shunted into thousands of hollow fibers 1006. Finally, after material exchange, the blood is merged in the confluence chamber 1004, pumped out through the blood discharge tube 1008 and returned to the human body.

[0034] Four filter cartridges 11 are arranged around the dialysis cartridge 10, and a filter column 12 is arranged in the filter cartridge 11. The bottom of the filter cartridge 11 is connected with the dialysis cartridge 10 through a first connecting tube 13, and a one-way valve is arranged in the first connecting tube 13. The upper part of the filter cartridge 11 is connected with the dialysis cartridge 10 through a second connecting tube 14, and a one-way valve is arranged in the second connecting tube 14. The filter cartridge 11 is provided with a waste liquid discharge port 15, and a dialysate replenishing port 16 is arranged at the upper end of the filter cartridge 11.

[0035] The lower end of the filter column 12 is provided with a diaphragm pump 17, and the diaphragm pump 17 includes a second sliding sleeve 1701. The bottom of the filter cartridge 11 is slidably connected with a lifting piston column 1702 through the second sliding sleeve 1701. The upper end of the lifting piston column 1702 is fixedly connected with a rubber bowl 1703. The edge of the rubber bowl 1703 is fixedly connected to the inner wall of the filter cartridge 11. The lower end of the lifting piston column 1702 is fixedly connected with a second magnet sheet 1704. A reset spring 1705 is provided between the second magnet sheet 1704 and the bottom of the filter cartridge 11. The positioning spring 1705 is sleeved on the outside of the lifting piston column 1702. There are four groups of lifting rods 7, first magnet pieces 8 and diaphragm pumps 17, and the four groups of diaphragm pumps 17 are respectively located at the bottom of four filter cartridges 11. The second magnet pieces 1704 in each group of diaphragm pumps 17 correspond to one first magnet piece 8, and the first magnet piece 8 and the second magnet piece 1704 attract each other. In this way, when the driving motor 4 drives the tilting driving disk 5 to rotate, the tilting driving disk 5 will drive the four lifting rods 7 to rise and fall periodically. When the lifting rod 7 is lowered, the lifting rod 7 will drive the lifting piston column 1702 in the diaphragm pump 17 to rise and fall periodically through the cooperation of the first magnet sheet 8 and the second magnet sheet 1704. When the lifting piston column 1702 is lowered, the lifting piston column 1702 pulls the rubber bowl 1703 downward, so that the volume of the space below the filter cartridge 11 increases and the pressure decreases, so that the one-way valve in the first connecting pipe 13 opens, and the dialysate in the dialysis chamber 1002 enters the lower part of the filter cartridge 11 through the first connecting pipe 13, and at the same time, fresh The dialysate will also be sucked into the upper part of the filter cartridge 11 from the dialysate replenishing port 16. When the lifting piston column 1702 rises, the lifting piston column 1702 pushes the rubber bowl 1703 upward, causing the volume of the lower space of the filter cartridge 11 to decrease and the pressure to increase, thereby closing the one-way valve in the first connecting tube 13 and opening the one-way valve in the second connecting tube 14. As a result, the dialysate in the lower part of the filter cartridge 11 is pushed by the pressure to pass through the filter column 12, reach the upper part of the filter cartridge 11, and return to the dialysis chamber 1002 through the second connecting tube 14.

[0036] Specifically, one end of the first connecting tube 13 is connected to the bottom of the dialysis chamber 1002, and the other end is connected to the bottom of the filter column 12. The waste liquid outlet 15 is also arranged below the filter column 12. One end of the second connecting tube 14 is connected to the top of the dialysis chamber 1002, and the other end is connected to the top of the filter column 12. The dialysate replenishing port 16 is opened above the filter column 12.

[0037] Example 2: The hollow fiber 1006 is made of polysulfone, which has good hydrophilicity, a glass transition temperature of 190°C, is resistant to high-temperature disinfection, can be steam sterilized at 121°C, has a porosity of 60% to 70%, and has both high mechanical strength and biocompatibility. Its tensile strength can reach 5 MPa. Amino groups are introduced into the membrane surface of the hollow fiber 1006 through plasma activation. The amino groups are covalently bonded to the heparin carboxyl groups, which prolongs the clotting time to 300-400s.

[0038] Embodiment 3: The filter column 12 is divided into four layers from bottom to top, namely, a nanofiber membrane layer 1201, an anion resin layer 1202, an activated carbon layer 1203 and a molecular sieve adsorption layer 1204. The combination of the four filter layers has a clearance rate of 92%, 88% and 78% for urea, creatinine and phosphorus respectively, and the dialysate can be effectively recovered.

[0039] Working principle: When using a multi-layer filtration blood purification dialysis device, first insert the hemodialyzer 9 into the dialyzer slot 2 of the hemodialysis machine 1, so that the second magnet piece 1704 at the bottom of the filter cartridge 11 and the first magnet piece 8 in the dialyzer slot 2 are attracted to each other, and then connect the pipeline, use a disposable hose to connect the dialysate replenishing port 16 on the filter cartridge 11 to the dialysate storage tank for replenishing fresh dialysate, and connect the waste liquid outlet 15 on the filter cartridge 11 to the waste liquid bucket for collecting waste liquid, and at the same time connect the blood injection tube 1007 and the blood discharge tube 1008 to the human body through the blood collection blood line, so that the drawn blood is pumped into the shunt chamber 1001 through the blood injection tube 1007, and then shunted into thousands of hollow fibers 1006, and finally after material exchange, the blood converges in the confluence chamber 1004, is pumped out through the blood discharge tube 1008 and returned to the human body.

[0040] During the dialysis process, when the driving motor 4 drives the tilting driving disk 5 to rotate, the tilting driving disk 5 will drive the four lifting rods 7 to rise and fall periodically, so that the lifting rods 7 will drive the lifting piston column 1702 in the diaphragm pump 17 to rise and fall periodically through the cooperation of the first magnet sheet 8 and the second magnet sheet 1704. When the lifting piston column 1702 descends, the lifting piston column 1702 pulls the rubber bowl 1703 downward, so that the volume of the lower space of the filter cartridge 11 increases and the pressure decreases, so that the one-way valve in the first connecting pipe 13 opens, and the dialysate in the dialysis chamber 1002 enters the lower part of the filter cartridge 11 through the first connecting pipe 13. At the same time, fresh dialysate will also be sucked into the upper part of the filter cartridge 11 from the dialysate replenishing port 16. When the lifting piston column 1702 rises, the lifting piston column 1702 pushes the rubber bowl 1703 upward, so that the volume of the lower space of the filter cartridge 11 decreases and the pressure increases, so that the one-way valve in the first connecting tube 13 is closed, and the one-way valve in the second connecting tube 14 is opened, so that the dialysate in the lower part of the filter cartridge 11 is pushed by the pressure to pass through the filter column 12 and reach the upper part of the filter cartridge 11, and return to the dialysis chamber 1002 through the second connecting tube 14, so that the dialysate circulates in the dialysis chamber 1002 and is filtered to remove the metabolic products absorbed and exchanged with the blood.

[0041] When the lifting piston column 1702 descends, not only the dialysate is sucked into the lower part of the filter cartridge 11 through the first connecting pipe 13, but the pressure also causes the dialysate in the filter column 12 to flow back to the lower part of the filter cartridge 11, thereby backwashing the filter column 12 and causing high-concentration metabolites to accumulate in the lower part of the filter cartridge 11. When the lifting piston column 1702 rises again, not only the dialysate in the lower part of the filter cartridge 11 is pushed through the filter column 12 by pressure to the upper part of the filter cartridge 11, but also the pressure valve at the waste liquid outlet 15 is pushed open to discharge part of the waste liquid. As the dialysis proceeds, the filter column 12 is gradually blocked, causing the pressure in the lower part of the filter cartridge 11 to gradually increase. The greater the pressure, the greater the opening amplitude of the pressure valve, and the more waste liquid is discharged from the waste liquid outlet 15, so that the waste liquid discharge volume can accurately match the toxin accumulation rate, and the fluctuation of the dialysate metabolite concentration is controlled within ±10%, and the KT / V value is stabilized at above 1.3.

[0042] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0043] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A multi-layer filtration blood purification dialysis device, characterized in that: The invention comprises a hemodialysis machine (1), wherein a dialyzer slot (2) is provided on the hemodialysis machine (1), a circulation drive (3) is provided at the bottom of the dialyzer slot (2), a drive motor (4) is provided in the circulation drive (3), an output shaft of the drive motor (4) is fixedly connected to an inclined drive disk (5) via a keyway, a lifting rod (7) is slidably connected to the upper part of the circulation drive (3) via a first sliding sleeve (6), the lifting rod (7) passes through the circulation drive (3), and a first magnet sheet (8) is fixedly connected to the upper end of the lifting rod (7); A hemodialyzer (9) is inserted into the dialyzer slot (2), a dialyzer (10) is arranged at the center of the hemodialyzer (9), four filter cartridges (11) are arranged around the dialyzer (10), a filter column (12) is arranged in the filter cartridge (11), the bottom of the filter cartridge (11) is connected to the dialyzer (10) through a first connecting pipe (13), a one-way valve is arranged in the first connecting pipe (13), the upper part of the filter cartridge (11) is connected to the dialyzer (10) through a second connecting pipe (14), a one-way valve is arranged in the second connecting pipe (14), a waste liquid discharge port (15) is provided in the filter cartridge (11), a dialysate replenishing port (16) is provided at the upper end of the filter cartridge (11), and a diaphragm pump (17) is arranged at the lower end of the filter column (12).

2. A multi-layer filtration blood purification dialysis device as claimed in claim 1, characterized in that: The plane where the inclined driving disc (5) is located is at an angle of 85°-95° ​​with the output shaft of the driving motor (4).

3. A multi-layer filtration blood purification dialysis device as claimed in claim 1, characterized in that: The tilting drive plate (5) is provided with an annular contact groove (501), and the bottom end of the lifting rod (7) is provided with a ball (701), and the ball (701) rolls in the contact groove (501).

4. A multi-layer filtration blood purification dialysis device as claimed in claim 1, characterized in that: A diversion chamber (1001) is provided at the upper end of the dialysis cartridge (10), a dialysis chamber (1002) is provided below the diversion chamber (1001), the diversion chamber (1001) and the dialysis chamber (1002) are separated by a first partition (1003), a confluence chamber (1004) is provided below the dialysis chamber (1002), the confluence chamber (1004) and the dialysis chamber (1002) are separated by a second partition (1005), and dense hollow fibers (1006) are provided between the first partition (1003) and the second partition (1005).

5. A multi-layer filtration blood purification dialysis device as claimed in claim 4, characterized in that: The upper end of the dialysis cartridge (10) is provided with a blood injection tube (1007) and a blood discharge tube (1008); the blood injection tube (1007) is connected to the diversion chamber (1001); the blood discharge tube (1008) passes through the dialysis chamber (1002) and is connected to the confluence chamber (1004).

6. A multi-layer filtration blood purification dialysis device as claimed in claim 4, characterized in that: The hollow fiber (1006) is made of polysulfone, and amino groups are introduced on the surface of the hollow fiber (1006) through plasma activation.

7. A multi-layer filtration blood purification dialysis device as claimed in claim 4, characterized in that: One end of the first connecting tube (13) is connected to the bottom of the dialysis chamber (1002), and the other end is connected to the bottom of the filter column (12). The waste liquid outlet (15) is also arranged below the filter column (12). One end of the second connecting tube (14) is connected to the top of the dialysis chamber (1002), and the other end is connected to the top of the filter column (12). The dialysate replenishing port (16) is opened above the filter column (12).

8. A multi-layer filtration blood purification dialysis device as claimed in claim 1, characterized in that: The filter column (12) is divided into four layers from bottom to top, namely a nanofiber membrane layer (1201), an anion resin layer (1202), an activated carbon layer (1203) and a molecular sieve adsorption layer (1204).

9. The multi-layer filtration blood purification dialysis device according to claim 1, characterized in that: The diaphragm pump (17) comprises a second sliding sleeve (1701), the bottom of the filter cartridge (11) is slidably connected to a lifting piston column (1702) via the second sliding sleeve (1701), the upper end of the lifting piston column (1702) is fixedly connected to a rubber bowl (1703), the edge of the rubber bowl (1703) is fixedly connected to the inner wall of the filter cartridge (11), the lower end of the lifting piston column (1702) is fixedly connected to a second magnet sheet (1704), a return spring (1705) is arranged between the second magnet sheet (1704) and the bottom of the filter cartridge (11), and the return spring (1705) is sleeved on the outside of the lifting piston column (1702).

10. A multi-layer filtration blood purification dialysis device as claimed in claim 9, characterized in that: The lifting rod (7), the first magnet sheet (8) and the diaphragm pump (17) are each provided in four groups, and the four groups of the diaphragm pump (17) are respectively located at the bottom of the four filter cartridges (11), and the second magnet sheet (1704) in each group of the diaphragm pump (17) corresponds to a first magnet sheet (8), and the first magnet sheet (8) and the second magnet sheet (1704) attract each other.

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