Intraoperative frozen pathology edge cutting equipment

By designing the multi-partition and fixed base structure of the sample table and sample hammer device, the problems of lack of sample labeling, long time to freeze fixation, difficulty in sample retrieval and poor flatness are solved, and efficient, stable and high-quality sample cutting is achieved.

CN119827200APending Publication Date: 2025-04-15THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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Patent Information

Application Number
CN202510015489.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-06
Publication Date
2025-04-15

AI Technical Summary

Technical Problem

In the prior art, the lack of sample labeling leads to confusion; the freezing and fixing take a long time and low operating efficiency; the sample retention is difficult and adhesion occurs frequently; the sample flatness is poor, and adjustment is time-consuming and labor-intensive.

Method used

An intraoperative frozen pathological margin device including a sample table, a sample hammer, a groove and a fixed base was designed. The surface of the sample table is divided into multiple partitions, and multi-directional cutting of the sample is achieved through partition identification. The sample hammer device has a fixed base and groove structure, providing stable support and precise positioning to ensure the stability and smoothness of the sample during the cutting process.

Benefits of technology

It improves the accuracy and efficiency of sample cutting operations, shortens the freezing time, enhances the stability and flatness of the sample, simplifies the sample extraction and cleaning process, and improves the overall cutting quality.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention belongs to the technical field of medical diagnosis, and discloses intraoperative frozen pathology edge cutting equipment which comprises a sample table, a sample hammer device, a groove and a fixed base, a plurality of partitions are designed on the surface of the sample table and comprise upper, lower, left, right, bottom and primary parts; a fixed base is arranged at the bottom of the sample hammer device; a groove is formed in the bottom of the fixed base. The method is convenient to operate and rapid in positioning, the partition marks on the sample table are clear, the accuracy and efficiency of sample cutting operation are remarkably improved, and manual operation errors are reduced. The sample hammer is matched with the freezing platform, so that the quick freezing and fixing of the sample are realized, the waiting time is reduced, and the high-efficiency cutting requirement is met. The sample hammer is firm in structure, vertical support and an accurate groove are provided, and it is ensured that the sample is kept stable in the cutting process and is not prone to deviation or breakage.
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Description

Technical Field

[0001] The invention belongs to the technical field of medical diagnosis, and in particular relates to an intraoperative frozen pathological resection margin device. Background Art

[0002] The lack of sample identification can easily cause confusion: In the traditional frozen slicer's production process, when the sample is placed on the freezing table, it is easy to cause confusion due to the lack of clear identification. Cryofixation takes a long time: The specimens taken from the oral or breast cutting edge during the operation cover five parts: upper, lower, left, right, and bottom, plus the primary tumor tissue, a total of six samples. When handling frozen samples during traditional surgery, it is necessary to drip OTC glue, perform embedding, and use sample hammers to reinforce the operation in sequence. The entire fixation process is time-consuming and slow, which has a negative impact on the production efficiency. There are obstacles to removing the sample tray: After the sample tray is reinforced with a quick-freezing hammer, the sample tray is often adhered to the freezing table or the quick-freezing hammer, making it more difficult to remove it later. The flatness of the sample varies significantly, and adjusting the sample chuck is time-consuming and laborious: In the traditional intraoperative frozen sectioning process, each sample needs to be finely adjusted in angle and position one by one, which undoubtedly prolongs the production operation time, and ultimately causes uneven sample cutting surfaces and greatly reduces the quality of the slices.

[0003] Based on the above analysis, the prior art reveals the following problems and defects:

[0004] (1) Lack of sample identification leads to confusion: Since the sample surfaces are not clearly labeled, confusion often occurs.

[0005] (2) Cryofixation is time-consuming: The fixation rate of traditional frozen samples is slow, which hinders the overall operational efficiency and prolongs the time for freezing reports.

[0006] (3) It is difficult to remove the sample tray: After the sample has gone through the cutting or fixing process, it is very easy for it to stick together, making the removal process difficult.

[0007] (4) The flatness of the sample is uneven, and it takes a long time to adjust the sample head: The traditional manual adjustment of the sample chuck is difficult to accurately adjust the flatness of the sample, which directly results in poor uniformity of the sample cutting surface. Summary of the invention

[0008] In view of the problems existing in the prior art, the present invention provides an intraoperative frozen pathological resection margin device.

[0009] The present invention is implemented in this way: an intraoperative frozen pathological resection margin device comprises:

[0010] Sample table, sample hammer, groove, fixed base;

[0011] The surface of the sample table is designed with multiple partitions, including top, bottom, left, right, bottom, and primary;

[0012] A fixed base is arranged at the bottom of the sample hammer device; a groove is arranged at the bottom of the fixed base; the number of the grooves is 6, and 6 sample trays can be placed at the same time. The quick-freezing hammer can quickly freeze 6 samples at one time.

[0013] Furthermore, the sample table surface is designed with multiple partitions; through the partition markings, the operator can achieve multi-directional cutting of the sample to meet operations at different angles and directions; the sample table has a stable structure and a flat surface, providing a stable support platform.

[0014] Furthermore, the sample hammer device is designed with a fixed base and an appropriate groove structure, which effectively stabilizes the sample in the vertical direction to avoid displacement or instability during cutting or adjustment; the groove design provides precise positioning to ensure that the sample can be quickly fixed or adjusted according to cutting requirements; the side of the sample hammer device has an easy-to-operate handle or structure.

[0015] Furthermore, the sample platform and sample hammer device can operate in a low-temperature environment and have good thermal conductivity; the sample is in contact with the external freezing system on the freezing platform, and with the help of efficient thermal conduction characteristics, the sample can be quickly cooled and maintained in a frozen state, ensuring the integrity and stability of the sample during the cutting process.

[0016] Furthermore, the easy-to-operate handle and structure of the sample hammer device enable the operator to quickly remove the sample; through the flat structure of the sample table and the stable support of the hammer base, the sample can be smoothly removed after the cutting is completed; at the same time, the sample table and the sample hammer device are easy to clean, ensuring the long-term performance of the device and the cleanliness of the operating environment.

[0017] In combination with the above technical solutions and the technical problems solved, the advantages and positive effects of the technical solutions to be protected by the present invention are as follows:

[0018] 1. Convenient operation and quick positioning: The partitions on the sample table are clearly marked, which significantly improves the accuracy and efficiency of sample cutting operations and reduces human operation errors.

[0019] 2. Fast cooling and shortened time: The sample hammer and freezing platform cooperate to achieve rapid freezing and fixation of samples, reduce waiting time, and meet the needs of high-efficiency cutting.

[0020] 3. Improved sample stability: The sample hammer has a solid structure, provides vertical support and precise grooves, ensuring that the sample remains stable during the cutting process and is not prone to deviation or breakage.

[0021] 4. Easy to remove and maintain: The optimized design makes it easy to remove the sample, simplifies the operation process, avoids adhesion or damage of the sample when removing it, and improves the overall cutting quality.

[0022] 5. Fine adjustment and high flatness: Supports fine adjustment and trimming of the sample head in different directions to ensure the flatness of the sample and the quality of the cutting surface to meet the experimental or analytical requirements.

[0023] Through the above technical scheme, the present invention effectively improves the operational accuracy, efficiency and stability of manual cutting of samples, and is suitable for cutting and analyzing frozen samples in multiple fields such as scientific research and medical diagnosis.

[0024] Second, as auxiliary evidence of the inventiveness of the claims of the present invention, it is also reflected in the following important aspects:

[0025] (1) The expected benefits and commercial value of the technical solution of the present invention after transformation are:

[0026] Rapid diagnosis: Intraoperative frozen sections can provide doctors with pathological diagnosis results in a short time (usually within 30 minutes), which greatly shortens the waiting time and enables doctors to quickly understand the nature of the diseased tissue and adjust the surgical plan in time.

[0027] Guiding surgery: Freezing the margins during surgery can clarify the nature of the lesion, including whether it is benign, borderline, or malignant, which is crucial for determining the scope of surgery, whether the tumor has infiltrated adjacent tissues, and lymph node metastasis. Based on the results of frozen sections, doctors can decide whether to expand the scope of surgery, perform lymph node dissection, or adjust the surgical margins to ensure the thoroughness and safety of the surgery.

[0028] Reduce the risk of secondary surgery: Through intraoperative freezing examination, doctors can immediately detect residual or recurrence of diseased tissue during the operation, thereby avoiding secondary surgery due to incomplete removal of the lesion, reducing the risk and burden on patients.

[0029] Improve treatment efficiency: Intraoperative frozen examination of resection margins enables doctors to obtain pathological diagnosis results immediately during the operation, so that they can quickly formulate the next treatment plan, including whether adjuvant treatment (such as radiotherapy, chemotherapy, etc.) is needed, thereby improving the efficiency and effectiveness of treatment.

[0030] Improve hospital competitiveness: The application of this device will improve the hospital's professional level and technical strength in the field of pathological diagnosis, enhance the hospital's competitiveness, and attract more patients to come for treatment.

[0031] Promote the development of related industries: With the popularization and application of this device, it will drive the development of related industries, such as the research and development, production and sales of frozen section machines, as well as the research and development of related pathological diagnostic technologies and equipment.

[0032] From the perspective of commercial value, the device has broad market prospects. With the continuous advancement of medical technology and the improvement of people's requirements for the quality of medical services, the demand for the device will continue to grow. At the same time, the device can also be combined with existing medical equipment and systems to form a more complete medical solution, further enhancing its commercial value.

[0033] (2) The technical solution of the present invention fills the technical gap in the industry at home and abroad:

[0034] With the continuous advancement of technology and changes in market demand, cryostat will develop towards higher precision, higher efficiency and more intelligent direction. At the same time, in order to meet the needs of different users, cryostat will also present more diversified characteristics. The new cutting edge device of the cryostat of the present invention will help improve the overall level and quality of frozen section technology, accelerate intraoperative frozen pathology diagnosis, and promote the further development of related technologies.

[0035] (3) The technical solution of the present invention solves the technical problems that people have been eager to solve but have never been able to solve successfully:

[0036] During the operation, the cutting edge tissue sections are quickly prepared and pathological diagnosis is performed to determine whether there is tumor tissue residue at the surgical cutting edge of the tumor site, which helps doctors make decisions quickly during the operation, formulate appropriate treatment plans, reduce the harm caused by secondary surgery to patients, and save medical expenses for patients. In the frozen section technology, fast and accurate freezing has always been a difficulty. Traditional cutting edge freezing section methods often rely on the experience of professional and technical personnel, and the slicing is time-consuming and the production effect is poor. The new cutting edge device of the frozen microtome of the present invention achieves precise control and positioning of the cutting edge by adopting advanced positioning technology and cutting algorithms, thus solving this technical problem. The application of this device will help improve the work efficiency of pathological technicians, greatly shorten the production time, improve the quality and accuracy of frozen sections, and provide a more reliable basis for pathological diagnosis.

[0037] (4) The technical solution of the present invention overcomes technical prejudice:

[0038] The technical solution of the present invention overcomes technical prejudice to a certain extent. In the past, people may worry that the operation of new devices is complicated and difficult to master. But in fact, many new devices are designed with user-friendliness and ease of use in mind, reducing the difficulty of operation by simplifying the operating process and providing an intuitive user interface. The new cutting edge device of the frozen microtome of the present invention is designed based on this concept. It takes into account user-friendliness and ease of use, realizes precise control of the cutting edge and rapid slice making, thereby overcoming traditional technical prejudice. The application of this device will help promote the further development of frozen section technology and improve the timeliness, accuracy and reliability of pathological diagnosis.

[0039] In summary, the new cutting edge device of the freezing microtome, as auxiliary evidence of the creativity of the claims of the present invention, is of great significance in terms of expected benefits and commercial value, filling technological gaps, solving technical problems and overcoming technological prejudices. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 It is a structural diagram of an intraoperative frozen pathological resection margin device provided by an embodiment of the present invention.

[0041] Figure 2 It is a bottom structural diagram of a sample hammer device provided in an embodiment of the present invention.

[0042] Figure 3 It is a structural diagram of a fixed base provided in an embodiment of the present invention.

[0043] Figure 1 Middle: 1. Sample table; 2. Sample hammer device; 3. Groove; 4. Fixed base. DETAILED DESCRIPTION

[0044] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0045] like Figure 1 As shown, an intraoperative frozen pathological resection margin device provided by an embodiment of the present invention includes:

[0046] Sample table 1, sample hammer device 2, groove 3, fixed base 4;

[0047] The surface of the sample stage 1 is designed with multiple partitions, including top, bottom, left, right, bottom, and primary;

[0048] A fixed base 4 is provided at the bottom of the sample hammer device 2; a groove 3 is provided at the bottom of the fixed base 4; the number of the grooves 3 is 6, and 6 sample trays can be placed at the same time, and the quick-freezing hammer can quickly freeze 6 samples at one time.

[0049] The sample table provided in the embodiment of the present invention is designed with multiple partitions on its surface; through the partition markings, the operator can achieve multi-directional cutting of the sample to meet operations at different angles and directions; the sample table has a stable structure and a flat surface, providing a stable support platform.

[0050] The sample table 1 of the present invention is designed with multiple partitions on its surface, including top, bottom, left, right, bottom, and primary. Through this partition design, the sample table can clearly divide different working areas, so that operators can accurately locate and cut according to the markings. Each partition has clear instructions to ensure the standardization and accuracy of the operation, avoid confusion, and thus improve work efficiency and cutting quality.

[0051] Through multiple partitions on the sample table, operators can achieve multi-directional cutting of samples. For example, the different marking areas of the sample table, such as top, bottom, left, right, bottom, and primary, allow operators to accurately cut samples from different angles. The setting of partitions not only helps to improve cutting efficiency, but also avoids problems such as failed or inaccurate cutting due to improper sample placement.

[0052] The sample hammer device 2 of the present invention is designed in combination with the fixed base 4 to ensure the stability of the quick freezing hammer during use. The bottom of the sample hammer device is connected to the fixed base, so that the sample can be firmly fixed on the base and is not easily displaced, thereby ensuring the accuracy during the cutting process. The stability of the base directly affects the cutting quality and prevents errors caused by unstable samples.

[0053] The groove 3 at the bottom of the fixed base 4 has an important functional role. The groove 3 provides an appropriate space for fixing and positioning the sample. Through this design, the sample can better fit the base during the cutting process, avoiding the deviation of the sample due to unstable external force. This structure ensures that the sample remains stable when cutting at different angles and directions, further improving the accuracy and efficiency of cutting.

[0054] The sample table provided by the present invention has a stable structure and a flat surface, which effectively provides a stable support platform for the sample. No matter how the operator adjusts the cutting angle of the sample, the sample table can ensure its stability, avoiding any cutting errors caused by the instability of the platform. The flat surface design can ensure the uniformity of the sample during the cutting process, avoiding the situation of uneven cutting caused by the uneven platform.

[0055] Through the above design, the device of the present invention can provide efficient support for operators. The multiple partitions of the sample table and the stable support platform not only improve the cutting accuracy, but also greatly simplify the operation process. Operators can complete the cutting task more easily, improve work efficiency, and reduce errors caused by improper operation, especially when freezing pathological cutting edges, which can ensure high-quality cutting effects and operational safety.

[0056] like Figure 2 , 3As shown, the design of the intraoperative frozen pathology cutting edge device provided by the embodiment of the present invention has a fixed base and an appropriate groove structure, which effectively stabilizes the sample in the vertical direction to avoid displacement or instability during the cutting or adjustment process; the groove design serves to provide precise positioning to ensure that the sample can be quickly fixed or adjusted according to the cutting requirements; the side of the sample hammer device is provided with a handle or structure that is easy to operate.

[0057] The sample platform and sample hammer device provided in the embodiment of the present invention can be operated in a low-temperature environment and have good thermal conductivity; the sample is in contact with the external freezing system on the freezing platform, and with the help of efficient heat conduction characteristics, the sample can be quickly cooled and maintained in a frozen state, ensuring the integrity and stability of the sample during the cutting process.

[0058] The easy-to-operate handle and structure of the sample hammer device provided in the embodiment of the present invention enable the operator to quickly remove the sample; through the flat structure of the sample table and the stable support of the hammer base, the sample can be smoothly removed after the cutting is completed; at the same time, the sample table and the sample hammer device are easy to clean, ensuring the long-term use performance of the device and the cleanliness of the operating environment.

[0059] The sample freezing table provided in the embodiment of the present invention is of suitable size, suitable for most slicer working rooms, fast and uniform freezing, with a groove (for placing the sample tray), and with markings (color / number / specific cutting edge position such as top, bottom, etc.);

[0060] The sample holder provided in the embodiment of the present invention is made of metal or plastic, with a logo and anti-overflow glue;

[0061] The sample hammer / quick-freezing hammer provided in the embodiment of the present invention is adapted in size to the sample freezing table, and applies pressure to accelerate the freezing speed of the sample.

[0062] The present invention is specifically implemented:

[0063] The invention relates to a special device for intraoperative frozen cutting edge freezing hardening, the main components of which include:

[0064] 1. Sample table:

[0065] The surface of the sample table is designed with multiple partitions, including top, bottom, left, right, bottom, and primary, which makes it easy for operators to quickly identify the location of the sample and avoid confusion during operation.

[0066] The sample table has a stable structure and a flat surface, which supports the positioning, adjustment and detailed cutting of samples in different directions to ensure accuracy.

[0067] 2. Sample hammer device:

[0068] The sample hammer has a fixed base to make the sample more stable in the vertical direction.

[0069] The hammer structure is designed with appropriate grooves to provide stable sample loading operation and facilitate the positioning of samples during processing.

[0070] The sample hammer device has an easy-to-operate handle or structure on the side to ensure that the sample can be quickly removed during use, thereby reducing cutting time.

[0071] 3. Freezing platform design:

[0072] The sample table and sample hammer device can operate in a low-temperature environment and have good thermal conductivity. Together with the rapid freezing system, they accelerate the fixation and cooling process of the sample and keep the sample in a stable state.

[0073] The frozen cutting process is combined with automatic or manual adjustment functions to ensure the flatness of the sample during the cutting process, and can support the detailed trimming of different sample heads.

[0074] 1. Sample table partition design and working principle

[0075] The sample table surface of the present invention is designed with multiple partitions, including top, bottom, left, right, bottom, and primary, which facilitates operators to quickly locate samples according to specific needs and avoid confusion and errors in operation. Through the partition identification, operators can achieve multi-directional cutting of samples to meet precise operations at different angles and directions. In addition, the sample table has a stable structure and a flat surface, providing a stable support platform to ensure that the sample will not be displaced or deflected during manual cutting, thereby improving the accuracy and efficiency of cutting.

[0076] 2. Positioning and stability of the sample hammer device

[0077] The design of the sample hammer device is an important part of the present invention. It has a fixed base and an appropriate groove structure, which can effectively stabilize the sample in the vertical direction to avoid displacement or instability during cutting or adjustment. The purpose of the groove design is to provide precise positioning to ensure that the sample can be quickly fixed or adjusted according to the cutting requirements. The side of the sample hammer device is equipped with an easy-to-operate handle or structure, so that the operator can easily remove the sample, shorten the operation time, reduce sample damage, and significantly improve the overall work efficiency.

[0078] 3. Rapid cooling and thermal conductivity of the freezing platform

[0079] The sample platform and sample hammer device of the present invention can be operated in a low temperature environment and have good thermal conductivity, which is the key to achieving rapid freezing and fixation. The sample is in contact with the external freezing system on the freezing platform. With the help of efficient thermal conductivity, the sample can be quickly cooled and kept in a frozen state, ensuring the integrity and stability of the sample during the cutting process. This process greatly reduces the cooling time and ensures that the sample will not be broken or deformed due to uneven temperature during cutting.

[0080] 4. Flatness and adjustment mechanism of frozen cutting process

[0081] During the freezing and cutting process, the present invention provides an automatic or manual adjustment function to ensure that the sample maintains high flatness under different operating requirements. The operator can fine-tune the sample and achieve multi-directional positioning and cutting through the combined structure of the sample table and the sample hammer device. In addition, the device supports detailed trimming of the sample heads with different adjustments to meet the high requirements for cutting flatness and accuracy in scientific research or clinical practice. This flexible adjustment mechanism improves the quality and stability of sample cutting.

[0082] 5. Convenience of sample removal and cleaning operations

[0083] The present invention specially designs an easy-to-operate handle and structure of the sample hammer device, so that the operator can quickly remove the sample and avoid the sample from sticking or being damaged during the removal process. Compared with the traditional device, the design of the present invention is more user-friendly and efficient. Through the flat structure of the sample table and the stable support of the hammer base, the sample can be smoothly removed after the cutting is completed, reducing residues and debris. At the same time, the sample table and the sample hammer device are easy to clean, ensuring the long-term performance of the device and the cleanliness of the operating environment.

[0084] 6. Multi-faceted application and realization of efficient cutting technology

[0085] The present invention integrates functions such as rapid cooling, precise positioning and smooth cutting through the joint design of the sample table and the sample hammer device. Whether in scientific research laboratories or clinical diagnosis scenarios, the device can provide efficient and high-quality sample processing effects. Operators can flexibly adjust the sample position according to needs to achieve multi-angle cutting and processing. Through rapid freezing and stable support, the present invention solves the problems of long cooling time, cumbersome operation, and easy breakage of samples in traditional manual cutting, and significantly improves work efficiency and sample processing quality.

[0086] Through the above working principle, the present invention provides a stable, accurate and efficient ice sample punching special sample table and sample hammer device for manual cutting edge frozen cutting, which is suitable for various scientific research and diagnosis needs and has strong practicality and innovation.

[0087] Example 1: Precise freezing and cutting of tissue samples

[0088] This embodiment utilizes the ice sample punching special sample table and sample hammer device for manual cutting edge freeze-hard cutting of the present invention to perform precise freeze-hard cutting operations on biological tissue samples.

[0089] 1. Operation steps:

[0090] Sample fixation: Place the fresh tissue sample in the groove of the sample hammer device, use the fixed base to keep the sample vertically stable, and manually adjust the sample position to achieve the appropriate cutting direction.

[0091] Rapid freezing: Place the sample table and sample hammer device on the freezing platform, start the rapid freezing system, and use efficient heat conduction to quickly cool the sample to a frozen state in a short time (the temperature is controlled at -20℃ to -80℃).

[0092] Precise cutting: According to the partitions marked on the sample table (upper, lower, left, right, bottom, primary), the operator quickly identifies and adjusts the sample position, and uses the cutting tool to manually cut the required sample slices to ensure the flatness and thickness of the cut surface.

[0093] Sample removal and cleaning: After cutting, the operator quickly removes the sample through the side handle of the sample hammer device to avoid adhesion and damage. Clean the sample table and sample hammer to ensure a clean environment for subsequent operations.

[0094] 2. Technical effects:

[0095] The freezing time is greatly shortened and the cutting efficiency is increased by more than 30%.

[0096] The sample table has clear partition markings to avoid direction confusion and ensure accurate operation.

[0097] The cut slices have uniform thickness, smooth surface, and no obvious damage or cracks.

[0098] Example 2: Processing of bacterial samples for drug sensitivity analysis

[0099] This embodiment applies the present invention to freeze-hardening cutting and fine positioning of bacterial samples in the process of drug sensitivity analysis.

[0100] 1. Operation steps:

[0101] Preparation of fresh surgical specimens: After freeze-drying the bacterial culture, transfer it to the sample hammer device, and use the sample hammer base to stably support the fresh surgical specimen to prevent displacement.

[0102] Cryofixation: Place the sample hammer device together with the sample table on the freezing platform, and use the freezing system to quickly cool the fresh surgical specimen to -40℃ to ensure that the specimen is frozen hard for cutting.

[0103] Partition positioning: Based on the multi-partition identification (upper, lower, left, right, bottom, primary) of the sample table, the sample position is carefully adjusted to ensure accurate cutting of the edge and center of the antibacterial zone of fresh surgical specimens.

[0104] Cutting and analysis: Use a manual cutting tool to cut the sample into thin slices, ensuring that the slice thickness is uniform. Then remove the sample and perform drug susceptibility analysis.

[0105] Cleaning and maintenance: After cutting, clean the sample table and sample hammer device to ensure the cleanliness of the equipment and reduce the risk of cross contamination.

[0106] 2. Technical effects:

[0107] The sample hammer device is used to achieve rapid positioning and stable support of fresh surgical specimens, improving cutting efficiency by more than 20%.

[0108] The partition identification function of the sample table ensures the accuracy of the cutting position of fresh surgical specimens, which helps to ensure the accuracy of drug sensitivity analysis.

[0109] The cut surface of the frozen sample is flat and the edge is complete, which is convenient for subsequent inhibition zone measurement and drug sensitivity analysis.

[0110] The above two embodiments respectively demonstrate the practical application of the present invention in the field of biological tissue cutting and drug sensitivity analysis of fresh surgical specimens, and prove the superior performance of the sample table and sample hammer device in precise positioning, rapid freezing and efficient cutting.

[0111] The specific application fields or related products of the present invention.

[0112] 1. Application fields

[0113] 1. Medical field

[0114] Rapid pathological diagnosis during surgery: During surgery, the new cutting edge device of the cryostat can quickly prepare sample slices, helping pathologists to quickly determine the nature of the diseased tissue, thereby guiding surgical decisions and reducing surgical risks. Especially in tumor surgery, the device can accurately determine the nature of the tumor and whether the cutting edge is clean, ensuring the appropriate scope of surgery and reducing the risk of tumor recurrence and complications.

[0115] Drug development and clinical trials: In drug development and clinical trials, the new cutting edge device of the cryostat can be used to prepare slices of drug targets, helping researchers observe the effects of drugs on tissues and evaluate the efficacy and safety of drugs.

[0116] 2. Biology

[0117] Histological research: In biological research, the new cutting edge device of the cryostat can be used to prepare slices of various biological tissues, including animal tissues, plant tissues, and microorganisms. By observing the slices of these tissues, researchers can study the morphology, structure, and function of cells and further reveal the mysteries of life activities.

[0118] Genetic research: In genetic research, the device can be used to prepare slices of gene expression products, helping researchers to observe the distribution and location of gene expression products and study the relationship between genes and diseases.

[0119] 2. Related Products

[0120] 1. High-end cryostat: These products are usually equipped with advanced cutting edge new devices, such as precise slicing control system, efficient refrigeration system and advanced sample handling system, etc. These functions can ensure the quality and efficiency of slicing and meet the high-demand scientific research and medical needs.

[0121] 2. Special cryosection consumables: Consumables that are compatible with cryosection machines, such as blades, specimen holders, anti-roll plates, etc., are also key factors in ensuring the quality of sections. With the development of new cutting edge devices, these consumables also need to be continuously optimized and upgraded to meet new sectioning requirements.

[0122] 3. Frozen section preparation system: This system includes a cryostat, sample processing equipment, microscope, etc., which are used to prepare and observe frozen sections. The development of new cutting edge devices can promote the upgrading and optimization of the entire system and improve the efficiency and accuracy of section preparation and observation.

[0123] In summary, the new cutting edge device of the cryostat has broad application prospects in the fields of medicine and biology, and has promoted the upgrading and optimization of related products. With the continuous development of science and technology, this device will play a more important role in the future.

[0124] Relevant evidence of the technical effects achieved by the embodiments of the present invention.

[0125] 1. Improvement of Slicing Quality and Precision

[0126] Slice uniformity: With advanced slicing technology and precise control systems, the new device can ensure the uniformity of slices and avoid uneven thickness. This is crucial for pathological diagnosis, histological research and other fields, and can improve the accuracy and reliability of diagnosis.

[0127] Slice clarity: The new device can provide clearer slice images, making details such as cell structure and tissue morphology more clearly visible. This will help researchers gain a deeper understanding of the structure and function of biological tissues and promote research progress in related fields.

[0128] 2. Improvement of slicing efficiency and operation convenience

[0129] Fast slicing: The new device has efficient slicing capabilities, and the slicing time is shortened from 10 minutes to 4 minutes, which can complete the slicing of a large number of samples in a short time. This improves slicing efficiency, reduces the labor intensity of operators, and shortens the time cycle of diagnosis or surgery.

[0130] Easy to operate: The new device adopts a user-friendly design and is compatible with most cryostat machines currently on the market, allowing operators to easily get started and quickly master the use of the device. This reduces the difficulty of operation and improves the convenience of operation.

[0131] III. Expert Evaluation

[0132] The pathology experts in our department spoke highly of the technical effect of the new device. They believe that the new device has significantly improved the quality of slices, efficiency of slices, and ease of operation, providing strong support for research and diagnosis in related fields.

[0133] 4. Technological Development and Innovation Trends

[0134] Continuous innovation: With the continuous development of science and technology, the cutting edge devices of cryostat are also constantly innovating and improving. For example, more advanced refrigeration technology and more precise control systems are used to further improve the quality and efficiency of slicing.

[0135] Multi-field application: In addition to the medical field, the new device is also widely used in biology, agronomy and other fields. Researchers in these fields use the new device to prepare high-quality slice samples, promoting research progress in related fields.

[0136] In summary, the new cutting edge device embodiment of the cryostat has achieved significant technical effects, including improved slice quality and accuracy, improved slice efficiency and ease of operation, etc. These technical effects have been verified and supported by expert evaluation. At the same time, with the continuous development of science and technology, the new device will continue to innovate and improve, providing more powerful support for research and diagnosis in related fields.

[0137] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any modifications, equivalent substitutions and improvements made by any technician familiar with the technical field within the technical scope disclosed by the present invention and within the spirit and principle of the present invention should be covered by the protection scope of the present invention.

Claims

1. An intraoperative frozen pathological resection margin device, characterized in that: The intraoperative frozen pathological resection margin equipment includes: Sample table, sample hammer device, groove, fixed base; The surface of the sample table is designed with multiple partitions, including top, bottom, left, right, bottom, and primary; A fixed base is arranged at the bottom of the sample hammer device; a groove is arranged at the bottom of the fixed base; the number of the grooves is 6, and 6 sample trays are placed at the same time. The quick-freezing hammer can quickly freeze 6 samples at one time.

2. The intraoperative frozen pathological resection margin device according to claim 1, characterized in that: The sample table surface is designed with multiple partitions; through the partition markings, the operator can achieve multi-directional cutting of the sample to meet operations at different angles and directions; The sample table has a solid structure and a flat surface, providing a stable support platform.

3. The intraoperative frozen pathological resection margin device according to claim 1, characterized in that: The sample hammer device has a fixed base and an appropriate groove structure, which effectively stabilizes the sample in the vertical direction to avoid displacement or instability during cutting or adjustment; the groove is used to provide precise positioning to ensure that the sample is quickly fixed or adjusted according to cutting requirements; the side of the sample hammer device has a handle or structure that is easy to operate.

4. The intraoperative frozen pathological resection margin device according to claim 1, characterized in that: The sample stage and the sample hammer device can operate in a low temperature environment; the sample is in contact with an external freezing system on the freezing platform.

5. The intraoperative frozen pathological resection margin device according to claim 1, characterized in that: The easy-to-operate handle and structure of the sample hammer device enable the operator to quickly remove the sample; through the flat structure of the sample table and the stable support of the hammer base, the sample can be smoothly removed after the cutting is completed; at the same time, the sample table and the sample hammer device are easy to clean, ensuring the long-term use performance of the device and the cleanliness of the operating environment.