Blood coagulation detection multichannel optical system and blood coagulation detector

Abstract

The invention discloses a multichannel optical system for blood coagulation detection and a blood coagulation detector. The system comprises a plurality of light source devices, a light combining device, a reflective array light splitting device, a sample detection device and a photoelectric detection device, the light combining device is used for combining the light beams emitted by the plurality of light source devices to obtain a main light beam; the reflective array light splitting device is used for uniformly splitting the main light beam to each sample detection area; the sample detection device is used for placing a plurality of to-be-detected samples; the photoelectric detection device is used for receiving the detection light beam passing through the sample detection device. According to the embodiment of the invention, the multi-band light source assembly for blood coagulation detection is realized through beam combination and shaping of a plurality of light sources, and the energy consistency of detection light beams in a plurality of detection channels is realized by simultaneously setting a plurality of different reflectivity for a plurality of bands, so that a multi-band multi-channel blood coagulation detection system is finally realized.

Description

Technical Field

[0001] The present application relates to the field of in vitro diagnosis, and in particular, to a multi-channel optical system for coagulation detection and a coagulation detector. Background Art

[0002] Against the backdrop of changes in the global population structure, the problem of population aging is becoming increasingly serious. Thrombotic diseases seriously threaten human life and health, and their incidence rate ranks highest among various diseases.

[0003] Coagulation test analysis provides an important basis for the screening, diagnosis, treatment and detection of thrombosis and thrombotic diseases. Its medical value is becoming increasingly prominent. At the same time, clinical treatment, efficiency and economy of coagulation tests have also put forward higher requirements. At present, many hospitals are often faced with the challenge of a large number of samples, most of which need to be processed quickly. Under the condition of ensuring high-quality detection, it is particularly important to achieve the detection and analysis of a large number of samples.

[0004] In order to improve the efficiency of the test, the magnetic bead method is currently used in coagulation detection and analysis. It uses a set of driving coils on both sides of the test cup to generate a constant alternating magnetic field for detection, which is relatively costly. Optical detection can effectively avoid this problem.

[0005] For the detection of optical items in coagulation analyzers, the light source needs to provide a variety of detection lights with specific wavelengths. At present, most coagulation analyzers use halogen lamps as light sources and combine them with multiple optical fibers to achieve light splitting. Due to the high heat generation and short life of halogen lamps, it is necessary to add heat dissipation devices and easily replaceable structures, which occupy a large space and increase the size of the whole machine. The light splitting form of multiple optical fibers has low coupling efficiency and requires additional lens groups to achieve optical fiber coupling in and out, which is costly. Summary of the invention

[0006] The purpose of the embodiments of the present application is to provide a multi-channel optical system for coagulation detection and a coagulation detector to improve the problems of low light energy utilization, large size and high cost of traditional coagulation detection optical systems.

[0007] In a first aspect, an embodiment of the present application provides a multi-channel optical system for coagulation detection, comprising: multiple light source devices, a light combining device, a reflective array spectrometer, a sample detection device and a photoelectric detection device; the light combining device is used to combine light beams emitted by multiple light source devices to obtain a main light beam; the reflective array spectrometer is used to evenly split the main light beam into each sample detection area; the sample detection device is used to place multiple samples to be detected; and the photoelectric detection device is used to receive a detection light beam passing through the sample detection device.

[0008] The embodiment of the present application can combine multiple light beams to obtain a main light beam by setting multiple light source devices and light combining devices in the multi-channel optical system for coagulation detection, and evenly split the main light beam to each sample detection area by setting a reflective array light splitting device to ensure that the incident light beam energy of each sample detection area is consistent. By setting the sample detection device, multiple samples to be detected are placed in the same detection area to ensure that multiple samples to be detected are detected at the same time. By setting the photoelectric detection device, the received detection light beam is converted into an electrical signal, thereby further amplifying the detection signal, thereby improving the light energy utilization rate of the multi-channel optical system for coagulation detection, reducing the overall volume and reducing the cost.

[0009] Furthermore, the multiple light source devices include: an ultraviolet light source device for emitting a first light beam, a blue light source device for emitting a second light beam, a green light source device for emitting a third light beam, a red light source device for emitting a fourth light beam, and a near-infrared light source device for emitting a fifth light beam; the first light beam, the second light beam, the third light beam, the fourth light beam and the fifth light beam are combined into the main light beam by the light combining device.

[0010] The embodiment of the present application can combine the light beams emitted by the five light source devices, namely ultraviolet, blue, green, red and near-infrared, into a main light beam by setting a light combining device, and transmit the main light beam to the reflective array spectrometer. Thus, the main light beam is a mixture of the five spectra of ultraviolet, blue, green, red and near-infrared, which makes it convenient to select different light source spectra as the detection light source according to actual detection needs.

[0011] Furthermore, the first light beam emitted by the ultraviolet light source device is reflected by the light combining device and then combined into the main light beam; the second light beam emitted by the blue light source device is reflected by the light combining device and then combined into the main light beam; the third light beam emitted by the green light source device is reflected by the light combining device and then combined into the main light beam; the fourth light beam emitted by the red light source device is reflected by the light combining device and then combined into the main light beam; the fifth light beam emitted by the near-infrared light source device is reflected by the light combining device and then combined into the main light beam.

[0012] The embodiment of the present application combines light by setting the characteristics of the light combining device, changing the direction of the light beam emitted by the light source device through transmission or reflection, and at the same time, folding the light path, thereby increasing the utilization rate of space and reducing the occupied space of the multi-channel optical system for coagulation detection.

[0013] Furthermore, the reflective array spectrometer comprises a plurality of spectroscopes with specific reflectivity, including: a first spectroscope for reflecting a light beam into a first sample channel, a second spectroscope for reflecting a light beam into a second sample channel, a third spectroscope for reflecting a light beam into a third sample channel, a fourth spectroscope for reflecting a light beam into a fourth sample channel, a fifth spectroscope for reflecting a light beam into a fifth sample channel, and a sixth spectroscope for reflecting a light beam into a sixth sample channel. The light-transmitting surfaces of the plurality of spectroscopes with specific reflectivity are coated with a wide-band reflective film with a specific reflectivity, and the other surfaces are coated with a wide-band anti-reflection film. The light-transmitting surface of the first beam splitter is coated with a first wide-band reflective film, and the other side is coated with a first wide-band anti-reflection film; the light-transmitting surface of the second beam splitter is coated with a second wide-band reflective film, and the other side is coated with a second wide-band anti-reflection film; the light-transmitting surface of the third beam splitter is coated with a third wide-band reflective film, and the other side is coated with a third wide-band anti-reflection film; the light-transmitting surface of the fourth beam splitter is coated with a fourth wide-band reflective film, and the other side is coated with a fourth wide-band anti-reflection film; the light-transmitting surface of the fifth beam splitter is coated with a fifth wide-band reflective film, and the other side is coated with a fifth wide-band anti-reflection film; the light-transmitting surface of the sixth beam splitter is coated with a sixth wide-band reflective film.

[0014] The embodiment of the present application achieves uniform distribution of energy of multiple channel light beams by setting a reflective array spectrometer through multiple spectrometers with specific reflectivity. The multiple spectrometers with specific reflectivity are coated with a wide-band reflective film with a specific reflectivity. The wide-band reflective film with a specific reflectivity establishes an equivalent calculation model of the reflective array according to a predetermined angle, and gives the reflectivity of light beams at different angles corresponding to each layer of the film system. When the main light beam passes through the reflective array spectrometer, the light beam enters the film system with a specific reflectivity, the linear transmission is destroyed, and the light beam changes the exit angle to achieve uniform light splitting. The energy of the exiting light beam of each layer of the film system is equal through calculation, and the calculated coating technical indicators are obtained;

[0015] The specific calculation steps are as follows:

[0016] According to the actual transmission of the light beam in the reflective array, the light beam only passes through each layer of the reflective film system once at most, and assuming that the initial light energy is 1, the energy emitted by the first wide-band reflective film is:

[0017] W1=R1

[0018] Where W1 is the energy reflected by the first broadband reflective film, R1 is the reflectivity of the first broadband reflective film; the energy emitted by the second broadband reflective film after being reflected once by the first broadband reflective film, its emitted equivalent energy is:

[0019] W2=(1-W1)*R2

[0020] Where W2 is the energy reflected by the second wide-band reflective film, and R2 is the reflectivity of the second wide-band reflective film. After the energy emitted by the third wide-band reflective film is reflected once by the first wide-band reflective film and once by the second wide-band reflective film, the equivalent energy emitted is:

[0021] W3=(1-W1-W2)*R3

[0022] Where W3 is the energy reflected by the third wide-band reflective film, and R3 is the reflectivity of the third wide-band reflective film. After the energy emitted by the fourth wide-band reflective film is reflected by the first wide-band reflective film, the second wide-band reflective film and the third wide-band reflective film, the emitted equivalent energy is:

[0023] W4=(1-W1-W2-W3)*R4

[0024] Where W4 is the energy reflected by the fourth wide-band reflective film, and R4 is the reflectivity of the fourth wide-band reflective film. After the energy emitted by the fifth wide-band reflective film is reflected by the first wide-band reflective film, the second wide-band reflective film, the third wide-band reflective film, and the fourth wide-band reflective film, the emitted equivalent energy is:

[0025] W5=(1-W1-W2-W3-W4)*R5

[0026] Where W5 is the energy reflected by the fifth wide-band reflective film, R5 is the reflectivity of the fifth wide-band reflective film; the energy emitted by the sixth wide-band reflective film is reflected by the first wide-band reflective film, the second wide-band reflective film, the third wide-band reflective film, the fourth wide-band reflective film and the fifth wide-band reflective film, and its emitted equivalent energy is:

[0027] W6=(1-W1-W2-W3-W4-W5)*R6

[0028] Wherein W6 is the energy reflected by the sixth wide-band reflection film, and R6 is the reflectivity of the sixth wide-band reflection film.

[0029] The reflectivity of each film layer at different angles is calculated to make the equivalent energy of the output light beam of each film layer as equal as possible to ensure the uniformity of the output light beam.

[0030] Furthermore, the system also includes: a sample detection device for placing multiple samples to be tested and a photoelectric detection device for receiving a detection light beam passing through the sample detection device, wherein the sample detection device places the multiple samples to be tested in the same detection area to ensure that the multiple samples to be tested are tested at the same time; the photoelectric detection device is used to convert the received detection light beam into an electrical signal, thereby further amplifying the detection signal.

[0031] Most preferably, the multi-channel optical system for coagulation detection comprises:

[0032] A plurality of light source devices, including: an ultraviolet light source device for emitting a first light beam, a blue light source device for emitting a second light beam, a green light source device for emitting a third light beam, a red light source device for emitting a fourth light beam, and a near-infrared light source device for emitting a fifth light beam;

[0033] The light combining device includes a near-infrared-transmitting and red-reflecting light splitting device, a red-transmitting and yellow-reflecting light splitting device, a yellow-transmitting and green-reflecting light splitting device, a green-transmitting and blue-reflecting light splitting device, and a blue-transmitting and ultraviolet-reflecting light splitting device;

[0034] A reflective array spectrometer, comprising a first spectrometer, a second spectrometer, a third spectrometer, a fourth spectrometer, a fifth spectrometer and a sixth spectrometer, for evenly splitting the main light beam into each sample detection area;

[0035] A sample detection device for placing a plurality of samples to be tested;

[0036] The photoelectric detection device is used to receive the detection light beam passing through the sample detection device.

[0037] In a second aspect, an embodiment of the present application provides a coagulation detector, comprising the above-mentioned coagulation detection multi-channel optical system.

[0038] Compared with the prior art, the present invention has the following beneficial technical effects:

[0039] First, the solution of combining and shaping multiple wavelength LEDs replaces the original solution of stacking multiple filters on halogen lamps, which improves the light energy of a single wavelength, simplifies the structural design and reduces the overall volume.

[0040] Second, the original multi-beam optical fiber splitting solution is eliminated, reducing the loss of optical fiber coupling in and out, improving the utilization rate of light energy while reducing the overall cost of the module;

[0041] Third, the film system design is optimized for specific bands, making the film layer more uniform and flatter.

[0042] Fourth, the present invention takes the uniformity of the energy of the output light beam of each layer of the reflective film system of the reflective array spectrometer as a criterion, evaluates the reflectivity of each layer of the film system to light beams at different angles through calculation, gives the coating technical indicators, and then uses the coating technical indicators as the optimization conditions for the film system design, establishes the film system structure, and finally coats the designed film system on the test piece, observes the test data to see whether it meets the coating technical indicator requirements, and if it does, coats it on the sputtering machine and the evaporator.

[0043] Other features and advantages of the present application will be described in the following description, and partly become apparent from the description, or be understood by practicing the embodiments of the present application. The purpose and other advantages of the present application can be realized and obtained by the structures specifically pointed out in the written description, claims and drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments of the present application will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0045] Figure 1 A schematic diagram of the structure of a multi-channel optical system for coagulation detection provided in an embodiment of the present application;

[0046] Figure 2 A schematic diagram of the optical path of a multi-channel optical system for coagulation detection provided in an embodiment of the present application;

[0047] Figure 3 A schematic diagram of the structures of various excitation light source modules provided in the embodiments of the present application;

[0048] Figure 4 Schematic diagram of the structures of various reflective array spectrometer modules provided in the embodiments of the present application;

[0049] Figure 5 A schematic diagram of the position of the beam splitter film layer provided in an embodiment of the present application;

[0050] Figure 6 A schematic diagram of the design curves of each layer of the light-splitting film system provided in the embodiment of the present application;

[0051] Figure 7 A schematic diagram of a design curve of an anti-reflection film system for a beam splitter provided in an embodiment of the present application;

[0052] Icons: 1-Near-infrared light source device; 2-Red light source device; 3-Green light source device; 4-Blue light source device; 5-Ultraviolet light source device; 6-Light combining device; 7-Reflection array spectrometer device; 8-Sample detection device; 9-Photoelectric detection device; DETAILED DESCRIPTION

[0053] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application.

[0054] In the description of this application, it should be noted that the terms "inside", "outside", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the product of the application is usually placed when in use, which is only for the convenience of describing this application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application. In addition, the terms "first", "second", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0055] Figure 1 A structural schematic diagram of a multi-channel optical system for coagulation detection provided in an embodiment of the present application, the embodiment of the present application provides a multi-channel optical system for coagulation detection, including: a near-infrared light source device 1, a red light source device 2, a green light source device 3, a blue light source device 4, an ultraviolet light source device 5, a light combining device 6, a reflective array spectrometer device 7, a sample detection device 8 and a photoelectric detection device 9; the light combining device 6 is used to combine light beams emitted by multiple light source devices to obtain a main light beam; the reflective array spectrometer device 7 is used to evenly split the main light beam into each sample detection area; the sample detection device 8 is used to place multiple samples to be detected; the photoelectric detection device 9 is used to receive the detection light beam passing through the sample detection device.

[0056] First, considering that in traditional coagulation detection systems, due to the limitation of the detection light source, usually only single-wavelength multi-sample detection can be performed or multiple wavelengths can only correspond to single sample detection, the detection items and the detection rate are limited.

[0057] In the optional implementation process of the present application, the following are arranged in the multi-channel optical system for coagulation detection: a near-infrared light source device 1, a red light source device 2, a green light source device 3, a blue light source device 4, an ultraviolet light source device 5, a light combining device 6, a reflective array spectrometer device 7, a sample detection device 8 and a photoelectric detection device 9. The light beams emitted by multiple light source devices of different bands are combined into a main light beam through the light combining device 6, and the main light beam is then evenly split through the reflective array spectrometer device 7, thereby finally realizing simultaneous detection of multiple wavelengths and multiple samples, thereby improving the detection efficiency while reducing the volume of the entire optical system and reducing the cost.

[0058] Figure 2 A schematic diagram of the optical path of a multi-channel optical system for coagulation detection provided in an embodiment of the present application is shown in FIG. Figure 2As shown, multiple light source devices emit light beams respectively, and the light beams emitted by the multiple light source devices are collimated by the lens group, combined into a main light beam by the light combining device 6, and the light combining device 6 transmits the main light beam to the reflective array spectrometer 7. The light combining device 6 combines the light beams emitted by multiple light sources into one direction, that is, into a main light beam, by changing the transmission direction of the light beams, thereby achieving the purpose of light combining. At the same time, since the light combining device 6 only changes the propagation direction of the light beam and does not change the properties of the light beam, it is ensured that the diffusion angles of each light beam are consistent while changing the propagation direction of each light beam.

[0059] Furthermore, after the main light beam is incident on the reflective array spectrometer 7, the reflective array spectrometer 7 includes a plurality of spectrometers with specific reflectivity, and the surface of the spectrometers is coated with a wide-band reflective film and an anti-reflection film with a specific reflectivity. When the main light beam is incident on the surface of the spectrometer, part of the light beam is reflected according to a specific energy ratio to enter a subsequent detection channel. By setting spectrometers with different reflectivities, uniform distribution of light beam energy in multiple detection channels can be achieved.

[0060] Afterwards, multiple detection light beams with uniform energy obtained by reflection from the reflection array spectrometer 7 are incident on respective detection channels and incident on the sample detection device 8. The sample detection device 8 is provided with multiple sample slots for testing, which are used to place different test samples. According to the different coagulation functions between samples, the energy of the detection light beam after passing through the sample to be tested is also different.

[0061] Finally, multiple detection light beams passing through the sample to be tested are received by the photoelectric detection device 9. The photoelectric detection device 9 is composed of multiple photodiodes. Each photodiode is used to receive the light beam signal of the corresponding detection channel, and realizes signal capture through photoelectric conversion. Finally, the purpose of detection is achieved through signal amplification and subsequent data processing.

[0062] The photoelectric detection device 9 is used to receive the detection light beam passing through the sample detection device. The photoelectric detection device 9 can be a photodiode or a photomultiplier tube. The specific type of the photoelectric detection device 9 is not limited and can be adjusted according to the actual detection accuracy.

[0063] Therefore, through the multi-channel optical system for coagulation detection provided in the embodiment of the present application, the main light beam is evenly split into each sample detection area through the reflection array spectrometer 7, ensuring that the incident light beam energy of each sample detection area is consistent, realizing multi-channel multi-spectral instant detection, improving the detection efficiency while reducing the overall volume and reducing costs.

[0064] Based on the above embodiment, multiple light source devices include: an ultraviolet light source device for emitting a first light beam, a blue light source device for emitting a second light beam, a green light source device for emitting a third light beam, a red light source device for emitting a fourth light beam, and a near-infrared light source device for emitting a fifth light beam; the first light beam, the second light beam, the third light beam, the fourth light beam and the fifth light beam are combined into a main light beam through the light combining device 6.

[0065] In an optional embodiment of the present application, if Figure 3 As shown, the first light beam emitted by the ultraviolet light source device 1 is reflected by the light combining device 6 and then combined into the main light beam, the second light beam emitted by the blue light source device 2 is reflected by the light combining device 2 and then combined into the main light beam, the third light beam emitted by the green light source device 3 is reflected by the light combining device 6 and then combined into the main light beam, the fourth light beam emitted by the red light source device 4 is reflected by the light combining device 6 and then combined into the main light beam, and the fifth light beam emitted by the near-infrared light source device 5 is transmitted through the light combining device 6 and then combined into the main light beam.

[0066] It is worth noting that if the setting positions of different light source devices are changed, light combining devices 6 with different performances can be set according to the positions of different light sources, so as to change the optical path of the light beam in a targeted manner for light combining. In order to combine light beams of different colors into the main light beam, light combining mirrors with different performances can be set in the light combining device 6. The light paths of the light beams of different colors are changed by the transmission or reflection of the light beams of different colors by the light combining mirrors, so that the optical paths of the light beams of different colors coincide with the optical path of the main light beam, thereby achieving light combining. The light combining device 6 may include a first light combining mirror, a second light combining mirror, a third light combining mirror, and a fourth light combining mirror. By adjusting the type of coating on the first light combining mirror, the second light combining mirror, the third light combining mirror, and the fourth light combining mirror, the performance of the first light combining mirror, the second light combining mirror, the third light combining mirror, and the fourth light combining mirror can be changed; the light combining device 6 may also include a first light combining prism and a second light combining prism.

[0067] Therefore, in the embodiment of the present application, by providing a light combining device 6, the number of times the light path of the light beam is deflected can be reduced, making it easier to combine the five light paths, reducing the difficulty of aligning the optical axis, and at the same time avoiding the problems of energy loss and energy unevenness caused by misalignment of the optical axis.

[0068] On the basis of the above embodiment, the reflective array spectrometer includes a plurality of spectroscopes with specific reflectivity, including: a first spectroscope for reflecting the light beam into the first sample channel, a second spectroscope for reflecting the light beam into the second sample channel, a third spectroscope for reflecting the light beam into the third sample channel, a fourth spectroscope for reflecting the light beam into the fourth sample channel, a fifth spectroscope for reflecting the light beam into the fifth sample channel, and a sixth spectroscope for reflecting the light beam into the sixth sample channel. The main light beam is evenly split into each sample detection area by the plurality of spectroscopes with specific reflectivity.

[0069] In an optional embodiment of the present application, if Figure 4 As shown, the first beam splitter reflects part of the energy of the main beam into the first sample channel, the second beam splitter reflects part of the energy of the main beam passing through the first beam splitter into the second sample channel, the third beam splitter reflects part of the energy of the main beam passing through the first beam splitter and the second beam splitter into the third sample channel, the fourth beam splitter reflects part of the energy of the main beam passing through the first beam splitter, the second beam splitter and the third beam splitter into the fourth sample channel, the fifth beam splitter reflects part of the energy of the main beam passing through the first beam splitter, the second beam splitter, the third beam splitter and the fourth beam splitter into the fifth sample channel, and the sixth beam splitter reflects the remaining part of the energy of the main beam passing through the first beam splitter, the second beam splitter, the third beam splitter, the fourth beam splitter and the fifth beam splitter into the sixth sample channel.

[0070] It is worth noting that if the setting positions of different samples and detectors are changed, a reflective array spectrometer 7 with different performances can be set according to the positions of different samples and detectors, so as to change the optical path of the detection light beam in a targeted manner for spectrometry. In order to achieve uniform spectrometry of the main light beam to multiple sample detection devices, spectrometers with different reflectivities can be set in the reflective array spectrometer 7. By adjusting the reflectivities of different spectrometers, the energy ratio of different detection channels can be changed to finally achieve uniform spectrometry. The reflective array spectrometer 7 can include a first spectrometer, a second spectrometer, a third spectrometer, a fourth spectrometer, a fifth spectrometer and a sixth spectrometer. By adjusting the type of coating on the first spectrometer, the second spectrometer, the third spectrometer, the fourth spectrometer, the fifth spectrometer and the sixth spectrometer, the performance of the first spectrometer, the second spectrometer, the third spectrometer, the fourth spectrometer, the fifth spectrometer and the sixth spectrometer can be changed;

[0071] Therefore, in the embodiment of the present application, by providing the reflective array spectrometer 7, the light path deflection direction of the light beam can be changed, so that the detection device and the detection position are more flexible, and the volume of the entire detection system is also reduced.

[0072] On the basis of the above embodiment, the reflective array spectrometer 7 needs to be coated with 6 layers of wide-band reflective films with specific reflectivity. In order to ensure the consistency of the reflected energy of each spectrometer, an equivalent calculation model of the reflective array is established, and the energy of the output light beam of each layer of the film is ensured to be equal through calculation.

[0073] The specific calculation steps are as follows:

[0074] According to the actual transmission of the light beam in the reflective array, the light beam only passes through each layer of the reflective film system once at most. Assuming that the initial light energy is 1, the energy emitted by the first layer of the reflective film system is:

[0075] W1=R1

[0076] Where R1 is the reflectivity of the first film system; the energy emitted by the second reflective film system is:

[0077] W2=(1-W1)*R2

[0078] Where R2 is the reflectivity of the second film system; the energy emitted by the third reflective film system is:

[0079] W3=(1-W1-W2)*R3

[0080] Where R3 is the reflectivity of the third film system; the energy emitted by the fourth reflective film system is:

[0081] W4=(1-W1-W2-W3)*R4

[0082] Where R4 is the reflectivity of the fourth film system; the energy emitted by the fifth reflective film system is:

[0083] W5=(1-W1-W2-W3-W4)*R5

[0084] Where R5 is the reflectivity of the fifth film system; the energy emitted by the sixth reflective film system is:

[0085] W6=(1-W1-W2-W3-W4-W5)*R6

[0086] Where R6 is the reflectivity of the fifth film system.

[0087] According to the above equivalent model calculation

[0088] According to the above equivalent model, the reflectivity of each layer of film at a specific transmission angle is as follows: Figure 6 The equivalent energy of the output light beam of each film is shown in Table 1.

[0089] Table 1

[0090] Beamsplitter No. Reflectivity First beam splitter S1:R=16.6% Second beam splitter S2:R=19.9% The third beam splitter S3:R=24.9% Fourth beam splitter S4: R=33.2% Fifth beam splitter S5: R = 49.7% Sixth Spectroscope S6: R=99.0%

[0091] According to the above results, this embodiment provides coating design indicators for specific wavelengths (330-350nm, 395-415nm, 565-585nm, 650-670nm, 790-810nm) of incident light: for the first layer of the film system, the reflectivity is required to be 16.6%±1% when the incident angle is between 42° and 48°; for the second layer of the film system, the reflectivity is required to be 19.9%±1 when the incident angle is between 42° and 48°. %; for the third film system, when the incident angle is between 42° and 48°, the reflectivity is required to be 24.9%±1%; for the fourth film system, when the incident angle is between 42° and 48°, the reflectivity is required to be 33.2%±1%; for the fifth film system, when the incident angle is between 42° and 48°, the reflectivity is required to be 49.7%±1%; for the sixth film system, when the incident angle is between 42° and 48°, the reflectivity is required to be 99.0%±1%;

[0092] like Figure 5 As shown, the beam splitting surfaces of the first, second, third, fourth and fifth beam splitters are coated with beam splitting films, and the other side needs to be coated with anti-reflection films for specific wavelengths to reduce energy loss and avoid the inhomogeneity of each detection channel; the other side of the sixth beam splitter does not need to be coated. The requirements for the anti-reflection film system are as follows: For the AR film system, when the incident angle is between 35° and 55°, Rmax < 0.5% @ 330-840nm.

[0093] According to the requirements of the above coating design indicators, the film system is designed for natural light. As shown in Table 2, the first layer of the beam splitting film is composed of 15 layers of optical thin films, including two materials with high refractive index Ta2O5 and low refractive index SiO2, with a total thickness of 854.2nm.

[0094] Table 2

[0095]

[0096] As shown in Table 3, the second beam splitting film is composed of 20 layers of optical thin films including two materials of high refractive index Ta2O5 and low refractive index SiO2, which are alternately formed, and the total thickness is 1272.53 nm.

[0097] Table 3

[0098]

[0099] As shown in Table 4, the third beam splitting film is composed of 18 layers of optical thin films including two materials of high refractive index Ta2O5 and low refractive index SiO2 alternately, with a total thickness of 1600.18 nm.

[0100] Table 4

[0101]

[0102] As shown in Table 5, the fourth beam splitting film is composed of 22 layers of optical thin films including two materials of high refractive index Ta2O5 and low refractive index SiO2, and the total thickness is 1877.73 nm.

[0103] Table 5

[0104]

[0105] As shown in Table 6, the fifth layer of the splitter film is composed of 32 layers of optical thin films including two materials of high refractive index Ta2O5 and low refractive index SiO2 alternately, with a total thickness of 2761.47nm.

[0106] Table 6

[0107]

[0108] As shown in Table 7, the sixth layer of the splitter film is composed of 76 layers of optical thin films including three materials of high refractive index Ta2O5 / Nb and low refractive index SiO2 alternately, with a total thickness of 6509.52 nm.

[0109] Table 7

[0110]

[0111] Figure 6 It is a schematic diagram of the design curve of each layer of the spectroscopic film system. It has been optimized and adjusted for specific bands (330-350nm, 395-415nm, 565-585nm, 650-670nm, 790-810nm). The flatness of the actual curve within the angle range meets the use requirements and conforms to the film system design requirements.

[0112] Figure 7 It is a schematic diagram of the design curve of the anti-reflection film system of the beam splitter. The overall optimization design is made for the wide band. The average reflectivity, absolute reflectivity and flatness meet the requirements within the design wavelength range.

[0113] In summary, an embodiment of the present application provides a structural schematic diagram of a multi-channel optical system for coagulation detection. An embodiment of the present application provides a multi-channel optical system for coagulation detection, including: a near-infrared light source device 1, a red light source device 2, a green light source device 3, a blue light source device 4, an ultraviolet light source device 5, a light combining device 6, a reflective array spectrometer device 7, a sample detection device 8 and a photoelectric detection device 9; the light combining device 6 is used to combine the light beams emitted by the multiple light source devices to obtain a main light beam; the reflective array spectrometer device 7 is used to evenly split the main light beam into each sample detection area; the sample detection device 8 is used to place multiple samples to be detected; the photoelectric detection device 9 is used to receive the detection light beam passing through the sample detection device; ultimately, multi-wavelength and multi-sample simultaneous detection is achieved, which improves the detection efficiency while reducing the volume of the entire optical system and reducing the cost.

[0114] The above description is only an embodiment of the present application and is not intended to limit the scope of protection of the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the scope of protection of the present application.

Claims

1. A multi-channel optical system for coagulation detection, comprising: A plurality of light source devices, sample detection devices and photoelectric detection devices, characterized in that they also include: a light combining device and a reflective array light splitting device; The light combining device is used to combine the light beams emitted by the multiple light source devices to obtain a main light beam; The reflective array light splitting device is used to evenly split the main light beam into each sample detection area of ​​the sample detection device; The sample detection device is used to place a plurality of samples to be detected; The photoelectric detection device is used to receive the detection light beam formed by transmission through the sample detection device.

2. The multi-channel optical system for coagulation detection according to claim 1, characterized in that: The multiple light source devices include: an ultraviolet light source device for emitting a first light beam, a blue light source device for emitting a second light beam, a green light source device for emitting a third light beam, a red light source device for emitting a fourth light beam, and a near-infrared light source device for emitting a fifth light beam; the first light beam, the second light beam, the third light beam, the fourth light beam and the fifth light beam are combined into the main light beam by the light combining device.

3. The multi-channel optical system for coagulation detection according to claim 1, characterized in that: The reflective array spectrometer comprises a plurality of reflectivity spectrometers, including: a first spectrometer for reflecting a light beam into a first sample channel, a second spectrometer for reflecting a light beam into a second sample channel, a third spectrometer for reflecting a light beam into a third sample channel, a fourth spectrometer for reflecting a light beam into a fourth sample channel, a fifth spectrometer for reflecting a light beam into a fifth sample channel, and a sixth spectrometer for reflecting a light beam into a sixth sample channel.

4. The multi-channel optical system for coagulation detection according to claim 3, characterized in that: The light-transmitting surface of the first beam splitter is coated with a first wide-band reflective film, and the other surface is coated with a first wide-band anti-reflection film; The light-transmitting surface of the second beam splitter is coated with a second wide-band reflective film, and the other surface is coated with a second wide-band anti-reflection film; The light-transmitting surface of the third beam splitter is coated with a third wide-band reflective film, and the other surface is coated with a third wide-band anti-reflection film; The light-transmitting surface of the fourth beam splitter is coated with a fourth wide-band reflective film, and the other surface is coated with a fourth wide-band anti-reflection film; The light-transmitting surface of the fifth beam splitter is coated with a fifth wide-band reflective film, and the other surface is coated with a fifth wide-band anti-reflection film; The light-transmitting surface of the sixth beam splitter is coated with a sixth wide-band reflective film.

5. The multi-channel optical system for coagulation detection according to claim 4, characterized in that: The coating technical indicators of the first wide-band reflective film, the second wide-band reflective film, the third wide-band reflective film, the fourth wide-band reflective film, the fifth wide-band reflective film and the sixth wide-band reflective film are obtained by establishing an equivalent calculation model of the reflection array, calculating the reflectivity of each wide-band reflective film at different angles, and ensuring that the energy of the light beam reflected by each wide-band reflective film is equal.

6. The multi-channel optical system for coagulation detection according to claim 5, characterized in that: The wide-band reflective film includes alternating high-refractive-index film layers and low-refractive-index film layers, wherein the high-refractive-index film layers are Ta2O5 or Nb, and the low-refractive-index film layers are SiO2.

7. The multi-channel optical system for coagulation detection according to claim 1, characterized in that: The sample detection device is used to place the sample to be tested, and the container of the sample to be tested is made of light-transmitting material.

8. The multi-channel optical system for coagulation detection according to claim 1, characterized in that: The photoelectric detection device is used to convert the received optical signal into an electrical signal.

9. A blood coagulation detector, characterized in that: A multi-channel optical system for coagulation detection comprising any one of claims 1 to 8.

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