A composition with good permeability and whitening effect and its preparation method

Abstract

The present invention relates to a composition with good permeability and whitening effect and a preparation method thereof, belonging to the technical field of skin care products. The composition of the present invention comprises the following components: by weight percentage, 0.5-3% niacinamide, 0.1-0.5% ascorbyl glucoside, 0.1-1% tetrahydromethylpyrimidine carboxylic acid, 0.1-10% shiitake mushroom mycelium extract solution, 0.05-5% raspberry extract solution, 0.05-5% wheat germ extract solution, 0.01-0.1% decapeptide-4 solution, 0.001-1% borneol solution, 0.05-1.2% preservative, 0.05-2% thickener and the balance deionized water. The active ingredients of the composition prepared by the present invention have good permeability, excellent whitening effect, and have very good market application prospects.

Description

Technical Field

[0001] The present invention belongs to the technical field of skin care products, and in particular relates to a composition with good permeability and whitening effect and a preparation method thereof. Background Art

[0002] Skin care products are products used to protect, nourish, and improve the condition of the skin. They are made from a variety of active ingredients formulated and compounded in appropriate proportions. To address different skin needs, most current skin care products focus on whitening, oil control, spot lightening, and moisturizing. Skin care products with whitening properties, in particular, occupy a significant market share and are highly popular. However, existing whitening skin care products still suffer from numerous drawbacks that limit their effectiveness. This is because, on the one hand, the active ingredients themselves have a very limited effect on skin whitening, and most require prolonged use before any visible whitening effect is seen. On the other hand, the skin is composed, from the outside in, of the epidermis, dermis, and subcutaneous tissue. While the stratum corneum in the epidermis effectively prevents water loss and the erosion of external harmful substances, this also creates a problem of difficulty for the whitening active ingredients in skin care products to "penetrate" or "permeate" the skin. Numerous studies have shown that the vast majority of whitening skin care products applied by people are "blocked" by the stratum corneum, making them difficult to be truly absorbed and utilized, thus significantly reducing their effectiveness. Summary of the Invention

[0003] In view of the problems existing in the prior art, the object of the present invention is to provide a composition with good permeability and whitening effect and a preparation method thereof.

[0004] The purpose of the present invention can be achieved through the following technical solutions:

[0005] A composition with good permeability and whitening effect comprises the following components: niacinamide, ascorbyl glucoside, ectoine, shiitake mushroom mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution, borneol solution, a preservative, a thickener and deionized water.

[0006] As a preferred technical solution of the present invention, the composition comprises the following components: by weight, 0.5-3% niacinamide, 0.1-0.5% ascorbyl glucoside, 0.1-1% tetrahydropyrimidine carboxylic acid, 0.1-10% shiitake mushroom mycelium extract solution, 0.05-5% raspberry extract solution, 0.05-5% wheat germ extract solution, 0.01-0.1% decapeptide-4 solution, 0.001-1% borneol solution, 0.05-1.2% preservative, 0.05-2% thickener, and the balance deionized water.

[0007] As a preferred technical solution of the present invention, the composition comprises the following components: by weight percentage, 1% niacinamide, 0.2% ascorbyl glucoside, 0.5% tetrahydropyrimidine carboxylic acid, 8% shiitake mushroom mycelium extract solution, 5% raspberry extract solution, 2% wheat germ extract solution, 0.05% decapeptide-4 solution, 0.4% borneol solution, 0.8% preservative, 0.25% thickener, and the balance deionized water.

[0008] As a preferred technical solution of the present invention, the shiitake mushroom mycelium extract solution is prepared by mixing 0.4% of shiitake mushroom mycelium extract, 60% of glycerol and 39.6% of deionized water, calculated by weight percentage.

[0009] As a preferred technical solution of the present invention, the raspberry extract solution is prepared by mixing 15% raspberry extract, 0.5% p-hydroxyacetophenone, 0.6% 1,2-hexanediol and 83.9% deionized water by weight.

[0010] As a preferred technical solution of the present invention, the wheat germ extract solution is prepared by mixing 2% wheat germ extract, 0.5% p-hydroxyacetophenone, 0.6% 1,2-hexanediol and 96.9% deionized water by weight.

[0011] As a preferred technical solution of the present invention, the decapeptide-4 solution is prepared by mixing, by weight percentage, 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water.

[0012] As a preferred technical solution of the present invention, the borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water by weight.

[0013] As a preferred technical solution of the present invention, the preservative includes caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 10-15:5-10:80.

[0014] As a preferred technical solution of the present invention, the thickener is at least one of carbomer, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, ammonium acryloyldimethyl taurate / VP copolymer, hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydrolyzed sclerotium (SCLEROTIUM ROLFSSII) gum and xanthan gum.

[0015] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0016] Step X: Add a thickener to deionized water according to the formula amount, then stir and mix at a constant temperature of 60-70°C for 30-45 minutes. Cool naturally to 45-50°C and keep warm. Then add niacinamide, ascorbyl glucoside, tetrahydropyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution, and borneol solution. Stir and mix at a constant temperature of 45-60 minutes. Then add a preservative, continue stirring and mixing at a constant temperature of 15-30 minutes, and cool naturally to room temperature. The preparation is completed.

[0017] Niacinamide is a classic ingredient in skin care products with whitening effects. It can reduce the transport of melanin to the skin surface, thereby reducing pigmentation and brightening the skin tone. At the same time, it also has a certain inhibitory ability on the activity of tyrosinase, achieving the effect of reducing melanin synthesis. In addition, niacinamide can also accelerate the metabolism of melanin and promote the renewal of skin cells. Ultimately, niacinamide can achieve skin whitening improvements through multiple pathways. The present invention still selects it as the most basic whitening active ingredient, and further amplifies and enhances the whitening effect by compounding it with other substances.

[0018] Ascorbyl glucoside is a derivative of vitamin C. Due to the poor stability of vitamin C, it is prone to oxidation during actual use, thus losing its whitening effect. Ascorbyl glucoside can solve this problem very well. When ascorbyl glucoside is absorbed by the skin, it will gradually convert into vitamin C, thereby exerting its whitening effect. By reducing the synthesis of dopaquinone and promoting its reduction to dopa, it can block the melanin production chain and achieve the effect of promoting whitening. More importantly, since "tanning" is the main factor for skin darkening, ascorbyl glucoside can greatly reduce the various free radicals produced by ultraviolet radiation, thereby playing a protective role before "darkening".

[0019] Tetrahydromethylpyrimidine carboxylic acid, also known as ectoine, is an amino acid derivative with excellent safety and stability. It mainly repairs cells damaged by ultraviolet rays and improves their resistance to ultraviolet rays, thereby reducing the production of melanin to a certain extent, promoting whitening effects, and playing a repairing role after "darkening".

[0020] Lentinus edodes mycelium extract is rich in polysaccharides, trace elements, terpenoids and other bioactive substances. It has a good activating effect on skin cells, can coordinate the natural renewal of skin cells, and balance the effects of protection and repair. At the same time, it not only has a certain active inhibitory effect on melanocytes, but also when compounded with other whitening active ingredients, it can produce a good synergistic effect and jointly promote the whitening effect.

[0021] Raspberry extract is an emerging natural plant extract, which is mainly composed of active ingredients such as flavonoids and organic acids. Among them, there are more than 50 organic acid compounds, such as ellagic acid, salicylic acid, shikimic acid, gallic acid, oxalic acid, malic acid, citric acid, etc. Therefore, when it acts on the skin surface, it can soften the stratum corneum, thereby weakening its "barrier" effect to a certain extent, opening channels, and promoting the penetration of whitening active ingredients, so that human skin can better absorb them.

[0022] Wheat germ extract is a new type of food rich in spermidine. It has been widely used in the field of food additives to supplement nutrients for the human body. The present invention adds a certain amount of wheat germ extract to the composition. Based on the fact that spermidine is easily ionized into positively charged molecules, it can hydrogen bond with negatively charged groups on the skin cell membrane, such as phosphate groups, through electrostatic interactions, thereby producing a cellular internalization effect and promoting the penetration of whitening active ingredients.

[0023] Decapeptide-4 is a synthetic peptide composed of multiple amino acids such as arginine, aspartic acid, cysteine, and glutamic acid. It is the earliest peptide substance used in transdermal mediation. It can not only penetrate into cells well, but also carry other active ingredients and promote their penetration in the stratum corneum, achieving excellent penetration-enhancing effect.

[0024] Borneol is widely used in the cosmetics field as a skin conditioning agent. In the composition, it mainly destroys the ordered lipid structure in the stratum corneum, thereby promoting the penetration of whitening active ingredients. In particular, it can make the tightly connected structure between cells looser, making it easier for the whitening active ingredients to diffuse and better exert their whitening effect.

[0025] Beneficial effects of the present invention:

[0026] (1) The present invention creatively adds ascorbyl glucoside, ectoine and shiitake mushroom mycelium extract to niacinamide as a classic whitening active ingredient, thereby giving the composition a more excellent whitening effect; niacinamide can play a whitening role in multiple ways such as reducing melanin deposition, inhibiting the activity of tyrosinase, and accelerating the metabolism of melanin, while ascorbyl glucoside and ectoine have protective and repairing effects on the skin before and after "darkening", respectively. At the same time, ascorbyl glucoside can also block the production chain of melanin. As for the shiitake mushroom mycelium extract, it can inhibit the activity of melanocytes, thereby promoting skin whitening. In addition, it can have a good activation effect on skin cells, synergistically enhance the synergy of other whitening active ingredients, and amplify the final whitening effect.

[0027] (2) The present invention is based on the problem that current whitening active ingredients are difficult to "penetrate" and "infiltrate". Most of them are "blocked" from the stratum corneum and difficult to be truly absorbed and utilized. The present invention creatively adds raspberry extract, wheat germ extract, decapeptide-4 and borneol into the composition as a composite penetration enhancer, which together play an excellent penetration-promoting role; raspberry extract can soften the stratum corneum and weaken its "barrier" effect; wheat germ extract is rich in spermidine and is easily ionized into positively charged molecules to form hydrogen bonds with negatively charged groups in the cell membrane, thereby producing a cell internalization effect and promoting the penetration of whitening active ingredients; decapeptide-4 itself is a transdermal-mediated peptide substance with excellent penetration-promoting effect; as for borneol, it can destroy the ordered lipid structure in the stratum corneum, making it looser, thereby facilitating the diffusion of whitening active ingredients.

[0028] (3) The compositions prepared by the present invention mostly use natural plant extracts, vitamin derivatives, and amino acid derivatives as main ingredients, and have the characteristics of high safety and low irritation. At the same time, when they act on human skin, they can have a good whitening effect and have very good market application prospects. DETAILED DESCRIPTION

[0029] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined purpose of the invention, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0030] All the shiitake mushroom mycelium extracts in the embodiments and comparative examples of the present invention were purchased directly from the market and purchased from Guangzhou Mingqi Biotechnology Co., Ltd. with a product specification of 10:1; all the raspberry extracts were purchased directly from the market and purchased from Guangzhou Zhenyoumei New Material Technology Co., Ltd. with a product specification of 10:1; all the wheat germ extracts were purchased directly from the market and purchased from Guangzhou Mingqi Biotechnology Co., Ltd. with a product specification of 10:1; all the decapeptide-4s were purchased directly from the market and purchased from Fujian Longsheng Biotechnology Co., Ltd.; all the glycoproteins were purchased directly from the market and purchased from Fujian Longsheng Biotechnology Co., Ltd.; all the PEG-40 hydrogenated castor oils were purchased directly from the market and purchased from BASF (China) Co., Ltd.; all the borneols were purchased directly from the market and purchased from Nanjing Lizhihong Biotechnology Co., Ltd. with a product name of natural borneol (dextrorotatory borneol); all the xanthan gums were purchased directly from the market and purchased from Cosphatec GmbH with a product name of X 34.

[0031] Example 1

[0032] A composition with good permeability and whitening effect comprises the following components: by weight percentage, 1% niacinamide, 0.2% ascorbyl glucoside, 0.5% ectoine, 8% shiitake mushroom mycelium extract solution, 5% raspberry extract solution, 2% wheat germ extract solution, 0.05% decapeptide-4 solution, 0.4% borneol solution, 0.8% preservative, 0.25% thickener, and the balance deionized water.

[0033] In terms of weight percentage, the shiitake mushroom mycelium extract solution is prepared by mixing 0.4% of shiitake mushroom mycelium extract, 60% of glycerol and the remainder of deionized water.

[0034] The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0035] The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

[0036] The decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water by weight percentage.

[0037] The borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water by weight.

[0038] The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 12:8:80.

[0039] The thickener is xanthan gum.

[0040] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0041] Step X: Add a thickener to deionized water according to the formula amount, then stir and mix at a constant temperature of 60°C for 30 minutes. Cool naturally to 45°C and keep warm. Then add niacinamide, ascorbyl glucoside, tetrahydropyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution, and borneol solution. Stir and mix at a constant temperature of 45 minutes. Then add a preservative, continue stirring and mixing at a constant temperature of 15 minutes, and cool naturally to room temperature. The preparation is completed.

[0042] Example 2

[0043] A composition with good permeability and whitening effect comprises the following components: by weight percentage, 0.5% of niacinamide, 0.1% of ascorbyl glucoside, 0.1% of tetrahydromethylpyrimidine carboxylic acid, 0.1% of shiitake mushroom mycelium extract solution, 0.05% of raspberry extract solution, 0.05% of wheat germ extract solution, 0.01% of decapeptide-4 solution, 0.001% of borneol solution, 0.05% of a preservative, 0.05% of a thickener, and the balance of deionized water.

[0044] In terms of weight percentage, the shiitake mushroom mycelium extract solution is prepared by mixing 0.4% of shiitake mushroom mycelium extract, 60% of glycerol and 39.6% of deionized water.

[0045] The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0046] The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

[0047] The decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water by weight percentage.

[0048] The borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water by weight.

[0049] The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 10:5:80.

[0050] The thickener is xanthan gum.

[0051] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0052] Step X: Add a thickener to deionized water according to the formula amount, then stir and mix at a constant temperature of 60°C for 30 minutes. Cool naturally to 45°C and keep warm. Then add niacinamide, ascorbyl glucoside, tetrahydropyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution, and borneol solution. Stir and mix at a constant temperature of 45 minutes. Then add a preservative, continue stirring and mixing at a constant temperature of 15 minutes, and cool naturally to room temperature. The preparation is completed.

[0053] Example 3

[0054] A composition with good permeability and whitening effect comprises the following components: by weight: 3% niacinamide, 0.5% ascorbyl glucoside, 1% tetrahydromethylpyrimidine carboxylic acid, 10% shiitake mushroom mycelium extract solution, 5% raspberry extract solution, 5% wheat germ extract solution, 0.1% decapeptide-4 solution, 1% borneol solution, 1.2% preservative, 2% thickener, and the balance deionized water.

[0055] In terms of weight percentage, the shiitake mushroom mycelium extract solution is prepared by mixing 0.4% of shiitake mushroom mycelium extract, 60% of glycerol and 39.6% of deionized water.

[0056] The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0057] The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

[0058] The decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water by weight percentage.

[0059] The borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water by weight.

[0060] The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 15:10:80.

[0061] The thickener is xanthan gum.

[0062] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0063] Step X: Add a thickener to deionized water according to the formula amount, then stir and mix at a constant temperature of 70°C for 45 minutes. Cool naturally to 50°C and keep warm. Then, add niacinamide, ascorbyl glucoside, tetrahydropyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution, and borneol solution. Stir and mix at a constant temperature of 60 minutes. Then, add a preservative, continue stirring and mixing at a constant temperature of 30 minutes, and cool naturally to room temperature. The preparation is completed.

[0064] Example 4

[0065] A composition with good permeability and whitening effect comprises the following components: by weight: 2% niacinamide, 0.3% ascorbyl glucoside, 0.5% ectoine, 7% shiitake mushroom mycelium extract solution, 2% raspberry extract solution, 2% wheat germ extract solution, 0.08% decapeptide-4 solution, 0.7% borneol solution, 0.08% preservative, 0.2% thickener, and 85.14% deionized water.

[0066] In terms of weight percentage, the shiitake mushroom mycelium extract solution is prepared by mixing 0.4% of shiitake mushroom mycelium extract, 60% of glycerol and 39.6% of deionized water.

[0067] The raspberry extract solution is prepared by mixing 15% of raspberry extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 83.9% of deionized water by weight.

[0068] The wheat germ extract solution is prepared by mixing 2% of wheat germ extract, 0.5% of p-hydroxyacetophenone, 0.6% of 1,2-hexanediol and 96.9% of deionized water by weight.

[0069] The decapeptide-4 solution is prepared by mixing 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein and 98.93% deionized water by weight percentage.

[0070] The borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water by weight.

[0071] The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the caprylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 13:8:80.

[0072] The thickener is xanthan gum.

[0073] A method for preparing a composition with good permeability and whitening effect, the preparation method comprising the following steps:

[0074] Step X: Add a thickener to deionized water according to the formula amount, then stir and mix at a constant temperature of 65°C for 40 minutes. Cool naturally to 48°C and keep warm. Then, add niacinamide, ascorbyl glucoside, tetrahydropyrimidine carboxylic acid, shiitake mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution, and borneol solution. Stir and mix at a constant temperature of 50 minutes. Then, add a preservative, continue stirring and mixing at a constant temperature of 25 minutes, and cool naturally to room temperature. The preparation is completed.

[0075] Comparative Example 1

[0076] Based on Example 1, nicotinamide was replaced with ascorbyl glucoside of equal weight, and the rest remained unchanged.

[0077] Comparative Example 2

[0078] Based on Example 1, ascorbyl glucoside was replaced by an equal weight of ectoine, and the rest remained unchanged.

[0079] Comparative Example 3

[0080] On the basis of Example 1, the ectoine was replaced by an equal weight of Lentinus edodes mycelium extract, and the rest remained unchanged.

[0081] Comparative Example 4

[0082] Based on Example 1, the shiitake mycelium extract was replaced with an equal weight of nicotinamide, and the rest remained unchanged.

[0083] Comparative Example 5

[0084] Based on Example 1, the raspberry extract was replaced by an equal weight of wheat germ extract, and the rest remained unchanged.

[0085] Comparative Example 6

[0086] Based on Example 1, the wheat germ extract was replaced with an equal weight of decapeptide-4, and the rest remained unchanged.

[0087] Comparative Example 7

[0088] Based on Example 1, decapeptide-4 was replaced by borneol of equal weight, and the rest remained unchanged.

[0089] Comparative Example 8

[0090] Based on Example 1, borneol was replaced by an equal weight of raspberry extract, and the rest remained unchanged.

[0091] Comparative Example 9

[0092] On the basis of Example 1, nicotinamide, ascorbyl glucoside, ectoine and Lentinus edodes mycelium extract were replaced by equal weights of deionized water, and the rest remained unchanged.

[0093] Comparative Example 10

[0094] On the basis of Example 1, raspberry extract, wheat germ extract, decapeptide-4 and borneol were replaced by equal weights of deionized water, and the rest remained unchanged.

[0095] Test Example 1

[0096] Whitening effect test:

[0097] Here are the steps:

[0098] (1) 300 volunteers (aged 24-35 years, female, with facial IT A° values ​​stable between 20-25° in the past 30 days) were selected and randomly divided into 15 groups, with 20 people in each group.

[0099] (2) Each group was smeared with the whitening composition prepared in Examples 1-4 and Comparative Examples 1-10 (one group was a blank group, smeared with deionized water), and the smearing conditions were: twice a day, 2 mL each time, the residence time was 6 hours, and then washed with deionized water, and the smearing was continued for 30 days, and the smearing position was the face.

[0100] (3) After 30 consecutive days of application, retest the ITA° value of the face and calculate the average growth rate. The larger the average growth rate, the lighter the skin color and the better the whitening effect.

[0101] Table 1. Whitening effect test results

[0102]

[0103]

[0104] From Test Example 1, it can be seen from the comparison between Example 1 and Comparative Examples 1-10 that the composition prepared by the present invention has excellent whitening effect and good permeability of the whitening active ingredient; Comparative Example 9 does not add the whitening active ingredient, and the improvement of whitening is very limited, which is negligible, which indirectly indicates that it is difficult to actually participate in whitening, and more importantly, it has a penetration-promoting effect on other whitening active ingredients; Comparative Example 10 does not add the composite penetration enhancer, although it also has a whitening effect to a certain extent, but the effect still has a lot of room for improvement; Comparative Examples 1-8 have an adverse effect on the whitening effect after replacing any whitening active ingredient or penetration enhancer, but are still better than Comparative Examples 9 and 10.

[0105] The above description is merely a preferred embodiment of the present invention and does not constitute any form of limitation to the present invention. Although the present invention has been disclosed as above in terms of a preferred embodiment, it is not intended to limit the present invention. Any person skilled in the art can, without departing from the scope of the technical solution of the present invention, make some changes or modifications to equivalent embodiments using the technical contents disclosed above. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A composition with good permeability and whitening effect, characterized in that: The composition comprises the following components: by weight percentage, 0.5-3% of nicotinamide, 0.1-0.5% of ascorbyl glucoside, 0.1-1% of ectoine, 0.1-10% of shiitake mycelium extract solution, 0.05-5% of raspberry extract solution, 0.05-5% of wheat germ extract solution, 0.01-0.1% of decapeptide-4 solution, 0.001-1% of borneol solution, 0.05-1.2% of a preservative, 0.05-2% of a thickener, and the balance of deionized water; The shiitake mushroom mycelium extract solution is prepared by mixing 0.4% of shiitake mushroom mycelium extract, 60% of glycerol and 39.6% of deionized water, by weight percentage; The raspberry extract solution is prepared by mixing 15% raspberry extract, 0.5% p-hydroxyacetophenone, 0.6% 1,2-hexanediol and 83.9% deionized water by weight; The wheat germ extract solution is prepared by mixing 2% wheat germ extract, 0.5% p-hydroxyacetophenone, 0.6% 1,2-hexanediol and 96.9% deionized water by weight; The decapeptide-4 solution is prepared by mixing, by weight percentage, 0.01% decapeptide-4, 0.9% sodium chloride, 0.15% disodium hydrogen phosphate, 0.01% glycoprotein, and 98.93% deionized water; The borneol solution is prepared by mixing 0.1% borneol, 10% PEG-40 hydrogenated castor oil and 89.9% deionized water by weight percentage; The preservative comprises capryloylhydroxamic acid, ethylhexylglycerin and butylene glycol; the mass ratio of the capryloylhydroxamic acid, the ethylhexylglycerin and the butylene glycol is 10-15:5-10:80; The thickener is at least one of carbomer, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, ammonium acryloyldimethyl taurate / VP copolymer, hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydrolyzed sclerotium (SCLEROTIUM ROLFSSII) gum and xanthan gum.

2. The composition with good permeability and whitening effect according to claim 1, characterized in that: The composition comprises the following components: by weight: 1% niacinamide, 0.2% ascorbyl glucoside, 0.5% ectoine, 8% shiitake mushroom mycelium extract solution, 5% raspberry extract solution, 2% wheat germ extract solution, 0.05% decapeptide-4 solution, 0.4% borneol solution, 0.8% preservative, 0.25% thickener, and the balance deionized water.

3. A method for preparing the composition with good permeability and whitening effect according to any one of claims 1 to 2, characterized in that: The preparation method comprises the following steps: According to the formula, a thickener is added to deionized water, and then the mixture is stirred at a constant temperature of 60-70°C for 30-45 minutes. The mixture is naturally cooled to 45-50°C and kept warm. Nicotinamide, ascorbyl glucoside, tetrahydromethylpyrimidine carboxylic acid, shiitake mushroom mycelium extract solution, raspberry extract solution, wheat germ extract solution, decapeptide-4 solution and borneol solution are added, and the mixture is stirred at a constant temperature for 45-60 minutes. Then, a preservative is added, and the mixture is stirred at a constant temperature for 15-30 minutes. The mixture is naturally cooled to room temperature, and the preparation is completed.

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